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https://www.readbyqxmd.com/read/30098921/sleep-quality-and-psychosocial-characteristics-of-patients-with-painful-post-traumatic-trigeminal-neuropathies
#1
Eduardo Vazquez-Delgado, Marta Viaplana-Gutierrez, Charles Carlson, Rui Figueiredo, Eduard Valmaseda-Castellon
OBJECTIVES: The aim of this study was to explore how pain and psychological distress influence the sleep quality of patients with painful post-traumatic trigeminal neuropathy (PPTN). STUDY DESIGN: Thirty-two patients with a diagnosis of PPTN according to the International Classification for Headache Disorders of the International Headache Society were enrolled. All patients completed a number of questionnaires that examined sleep quality, psychological distress, and quality of life...
June 12, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/30086430/diagnosis-of-brain-metastases-in-breast-cancer-patients-resulting-from-neurological-symptoms
#2
Bernardo Cacho-Díaz, Héctor Spínola-Maroño, Victor A Arrieta, Martin Granados-García, Talia Wegman-Ostrosky, Laura G Mendoza-Olivas, Mariana Chávez-MacGregor
OBJECTIVES: Breast cancer (BC) is the leading cause of morbidity and mortality. Neurological symptoms are highly feared because they are associated with central nervous system metastases (CNSm). So, we aimed to analyze the association of neurological symptoms with CNSm. PATIENTS & METHODS: Patients with BC referred for a neuro-oncological evaluation at a cancer referral center from June 2012 to December 2017 were included. Demographic, oncological history, comorbidities, clinical symptoms and signs, and their correlation with CNSm were prospectively acquired during consultation in a computerized database...
August 2, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/30080243/the-greater-occipital-nerve-and-its-spinal-and-brainstem-afferent-projections-a-stereological-and-tract-tracing-study-in-the-rat
#3
Nuria García-Magro, Yasmina B Martin, Pilar Negredo, Carlos Avendaño
The neuromodulation of the greater occipital nerve (GON) has proved effective to treat chronic refractory neurovascular headaches, in particular migraine and cluster headache. Moreover, animal studies have shown convergence of cervical and trigeminal afferents on the same territories of the upper cervical and lower medullary dorsal horn (DH), the so-called trigeminocervical complex (TCC), and recent studies in rat models of migraine and craniofacial neuropathy have shown that GON block or stimulation alter nociceptive processing in TCC...
August 6, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/30072073/neurologic-complications-of-radiation-therapy
#4
REVIEW
Shyam K Tanguturi, Brian M Alexander
Cranial radiation therapy (CRT) is used to treat a wide range of malignant and benign conditions and is associated with a unique set of risks and complications. Early complications from CRT include fatigue, skin reaction, alopecia, headaches, anorexia, nausea/vomiting, exacerbation of neurologic symptoms, serous otitis media, parotitis, and encephalopathy. Delayed complications include pseudoprogression, radiation necrosis, neurocognitive changes, cerebrovascular effects, migrainelike disorders, cataracts, xerophthalmia, optic neuropathy, hearing loss, tinnitus, chronic otitis, endocrinopathy, and secondary malignancy...
August 2018: Neurologic Clinics
https://www.readbyqxmd.com/read/30026995/rhinogenic-optic-neuritis-caused-by-sphenoid-mucocele-with-sinusitis
#5
Sasitorn Siritho, Weerachai Tantinikorn, Paithoon Wichiwaniwate, Krit Pongpirul
A 59-year-old male who presented with a nonspecific headache at the vertex, resembling retrobulbar optic neuritis, was treated as such but did not show any improvement. Although optic nerve compression from sphenoid mucocele was finally discovered, the delayed diagnosis and improper treatment led to a permanent visual loss. Optic neuritis could be caused by a common problem, "mucocele/sinusitis," but might be easily overlooked in general practice. Rhinogenic optic neuropathy should, therefore, be considered in every case of optic neuritis whenever atypical presentation occurs or is unresponsive to high-dose steroid treatment...
2018: Case Reports in Radiology
https://www.readbyqxmd.com/read/30014839/case-series-of-severe-neurologic-sequelae-of-ebola-virus-disease-during-epidemic-sierra-leone
#6
Patrick J Howlett, Anna R Walder, Durodami R Lisk, Felicity Fitzgerald, Stephen Sevalie, Marta Lado, Abdul N'jai, Colin S Brown, Foday Sahr, Foday Sesay, Jonathon M Read, Paul J Steptoe, Nicholas A V Beare, Reena Dwivedi, Marylou Solbrig, Gibrilla F Deen, Tom Solomon, Malcolm G Semple, Janet T Scott
We describe a case series of 35 Ebola virus disease (EVD) survivors during the epidemic in West Africa who had neurologic and accompanying psychiatric sequelae. Survivors meeting neurologic criteria were invited from a cohort of 361 EVD survivors to attend a preliminary clinic. Those whose severe neurologic features were documented in the preliminary clinic were referred for specialist neurologic evaluation, ophthalmologic examination, and psychiatric assessment. Of 35 survivors with neurologic sequelae, 13 had migraine headache, 2 stroke, 2 peripheral sensory neuropathy, and 2 peripheral nerve lesions...
August 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/30002929/neuropsychiatric-involvement-in-juvenile-onset-systemic-lupus-erythematosus
#7
Mohammad-Amin Khajezadeh, Gholamreza Zamani, Bobak Moazzami, Zahra Nagahi, Mahdie Mousavi-Torshizi, Vahid Ziaee
Objective: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by multisystem involvement, including the nervous system. In the present study, we aimed to assess neuropsychiatric manifestations in juvenile-onset systemic lupus erythematosus (JSLE) in Iran. Methods: One hundred and forty-six pediatric onset patients with SLE who had registered in our pediatric rheumatology database were evaluated prospectively and cross sectionally within 2013-2015...
2018: Neurology Research International
https://www.readbyqxmd.com/read/30001923/oral-fingolimod-for-chronic-inflammatory-demyelinating-polyradiculoneuropathy-forcidp-trial-a-double-blind-multicentre-randomised-controlled-trial
#8
Richard Hughes, Marinos C Dalakas, Ingemar Merkies, Norman Latov, Jean-Marc Léger, Eduardo Nobile-Orazio, Gen Sobue, Angela Genge, David Cornblath, Martin Merschhemke, Carolyn Marie Ervin, Catherine Agoropoulou, Hans-Peter Hartung
BACKGROUND: Fingolimod is approved for the treatment of relapsing-remitting multiple sclerosis and was effective in experimental autoimmune neuritis in rats, a possible model for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We aimed to evaluate the efficacy of fingolimod in delaying disability progression in patients with CIDP who withdrew from currently effective treatments (intravenous immunoglobulin [IVIg] or corticosteroids). METHODS: This double-blind, multicentre, randomised, placebo-controlled, parallel-group, event-driven study was done at 48 neurology centres in Australia, Canada, Israel, Japan, the USA, and nine countries in Europe...
August 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30001820/clinical-manifestations-and-location-of-brain-metastases-as-prognostic-markers
#9
Bernardo Cacho-Díaz, Nydia A Lorenzana-Mendoza, J Danaé Chávez-Hernandez, Alberto González-Aguilar, Gervith Reyes-Soto, Ángel Herrera-Gómez
BACKGROUND: Brain metastases (BM) are a frequent complication of cancer and are regularly seen in clinical practice. New treatment modalities are improving survival after diagnosis of BM. However, symptoms are rarely reported and their significance is not well established. The aim of the present study was to investigate neurologic indicators as prognostic markers in patients with brain metastases. PATIENTS AND METHODS: A prospectively acquired database from 2 referral centers was analyzed...
June 12, 2018: Current Problems in Cancer
https://www.readbyqxmd.com/read/29906006/topical-application-of-5-fluorouracil-5-percent-cream-associated-with-severe-neutropenia-discussion-of-a-case-and-review-of-systemic-reactions-after-topical-treatment-with-5-fluorouracil
#10
Philip R Cohen
5-fluorouracil, a fluoropyrimidine antineoplastic drug, is used to topically treat actinic keratoses. Local skin reactions to the medication are common and anticipated. However, severe adverse events from topical 5-fluorouracil are rare and unexpected. A 69-year-old man with a lower lip actinic keratosis developed severe neutropenia on day 11 of topical 5-fluorouracil treatment - after 14 applications. After receiving a subcutaneous injection of filgrastim, his neutrophil count normalized. The PubMed database was used to search the following terms: agranulocytosis, cream, 5-fluorouracil, granulocytopenia, neutropenia, severe, systemic, topical, and toxicity...
April 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29904898/relapsing-painful-ophthalmoplegic-neuropathy-no-longer-a-migraine-but-still-a-headache
#11
REVIEW
Stacy V Smith, Nathaniel M Schuster
PURPOSE OF REVIEW: Recurrent painful ophthalmoplegic neuropathy (RPON), formerly known as ophthalmoplegic migraine, is an uncommon disorder with repeated episodes of ocular cranial nerve neuropathy associated with ipsilateral headache. This review discusses the clinical presentation, current understanding of the pathophysiology, key differential diagnoses, and evaluation and treatment of RPON. RECENT FINDINGS: The literature is limited due to the rarity of the disorder...
June 14, 2018: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/29877580/patients-with-migraine-have-substantial-reductions-in-measures-of-visual-quality-of-life
#12
Laura L Hanson, Zubair Ahmed, Bradley J Katz, Judith E A Warner, Alison V Crum, Yingying Zhang, Yue Zhang, Susan Baggaley, Karly Pippitt, Melissa M Cortez, Kathleen B Digre
OBJECTIVE: Migraine is associated with several important visual symptoms, during both acute attacks and headache-free intervals. The purpose of this investigation was to use validated vision-related quality of life instruments to assess the effect of migraine on visual quality of life. BACKGROUND: Many migraineurs experience visual aura, increased photophobia during and between headache attacks, and increased symptoms of dry eye with structural changes in corneal nerve endings...
June 7, 2018: Headache
https://www.readbyqxmd.com/read/29864098/activity-and-exercise-intolerance-after-concussion-identification-and-management-of-postural-orthostatic-tachycardia-syndrome
#13
Nicole A Miranda, Jeffrey R Boris, Kristen M Kouvel, Lauren Stiles
BACKGROUND AND PURPOSE: Postural orthostatic tachycardia syndrome (POTS) is increasingly recognized as a complication affecting recovery from concussion. Individuals with POTS demonstrate refractory dizziness, lightheadedness, cognitive dysfunction, fatigue, headache, chronic pain, nausea and gastrointestinal dysmotility, activity and exercise intolerance, syncope, and tachycardia. Subtypes of POTS may include hypovolemia, hyperadrenergic states, autonomic neuropathy, and underlying autoimmunity, which may variably impact response to rehabilitation in varying ways...
July 2018: Journal of Neurologic Physical Therapy: JNPT
https://www.readbyqxmd.com/read/29726777/surgical-outcomes-after-reoperation-for-recurrent-skull-base-meningiomas
#14
Stephen T Magill, David S Lee, Adam J Yen, Calixto-Hope G Lucas, David R Raleigh, Manish K Aghi, Philip V Theodosopoulos, Michael W McDermott
OBJECTIVE Skull base meningiomas are surgically challenging tumors due to the intricate skull base anatomy and the proximity of cranial nerves and critical cerebral vasculature. Many studies have reported outcomes after primary resection of skull base meningiomas; however, little is known about outcomes after reoperation for recurrent skull base meningiomas. Since reoperation is one treatment option for patients with recurrent meningioma, the authors sought to define the risk profile for reoperation of skull base meningiomas...
May 4, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29678819/reversible-metronidazole-induced-neurotoxicity-after-10-weeks-of-therapy
#15
Wafa AlDhaleei, Ayesha AlMarzooqi, Nouran Gaber
Metronidazole is a commonly used antimicrobial worldwide. The most common side effects that have been reported are nausea, vomiting and hypersensitivity reactions. However, neurotoxicity has been reported with the use of metronidazole but rather rare. The most common neurological manifestation is peripheral neuropathy involvement in the form of sensory loss. It is worth mentioning that central neurotoxicity is a rare side effect of metronidazole use but reversible. The manifestations vary from a headache, altered mental status to focal neurological deficits...
April 20, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29662290/extra-intestinal-manifestations-of-non-celiac-gluten-sensitivity-an-expanding-paradigm
#16
REVIEW
Giuseppe Losurdo, Mariabeatrice Principi, Andrea Iannone, Annacinzia Amoruso, Enzo Ierardi, Alfredo Di Leo, Michele Barone
Non celiac gluten sensitivity (NCGS) is a syndrome characterized by a cohort of symptoms related to the ingestion of gluten-containing food in subjects who are not affected by celiac disease (CD) or wheat allergy. The possibility of systemic manifestations in this condition has been suggested by some reports. In most cases they are characterized by vague symptoms such as 'foggy mind', headache, fatigue, joint and muscle pain, leg or arm numbness even if more specific complaints have been described. NCGS has an immune-related background...
April 14, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29610715/complications-of-subcutaneous-contraception-a-review
#17
REVIEW
Rebecca C Ramdhan, Emily Simonds, Charlotte Wilson, Marios Loukas, Rod J Oskouian, R Shane Tubbs
Over 62 million women in the United States are of childbearing age and 60% of them use contraception. Subcutaneous contraceptives include implantable contraceptives and subcutaneous injections. Implantable contraception involves subdermal time-release of synthetic progestin, which allows for several years of continuous, highly effective contraception. Its main effects are inhibition of ovulation and thickening of the cervical mucus. Many complications have been associated with subcutaneous contraception, including menstrual disturbances, headache, weight gain, acne, dizziness, mood disturbances, nausea, lower abdominal pain, hair loss, loss of libido, pain at the implant site, neuropathy, and follicular cysts...
January 31, 2018: Curēus
https://www.readbyqxmd.com/read/29574434/herpes-zoster-ophthalmicus-evolving-into-headache-characterised-as-hemicrania-continua
#18
Sanjay Prakash, Ankit Dave, Hemant Joshi
Postherpetic neuralgia (PHN) is the most common chronic complication of herpes zoster infection. However, a few patients may develop different types of pain after herpetic lesions. We are reporting two patients who developed postherpetic hemicrania continua (HC). Case 1: a 54-year-old woman had a 10-month history of continuous left-sided pain with superimposed exacerbations. The pain started with the onset of herpetic lesions in the ophthalmic division. The lesions subsided in a few weeks. However, the pain persisted and it responded exclusively to indomethacin...
March 23, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29565948/a-randomized-double-blind-study-of-the-effects-of-a-sustained-release-formulation-of-sodium-nitrite-sr-nitrite-on-patients-with-diabetic-neuropathy
#19
Amol Soin, Glen Bock, Anthony Giordano, Chirag Patel, David Drachman
BACKGROUND: Sodium nitrite has been reported to be effective in reducing chronic peripheral pain. OBJECTIVES: To evaluate the safety and efficacy of 40 and 80 mg, BID, of an oral sustained release formulation of sodium nitrite (SR-nitrite) in patients suffering from diabetic neuropathy, and to determine whether SR-nitrite would reduce the frequency of headaches reported previously by subjects receiving the same doses of an immediate release formulation. STUDY DESIGN: Phase II, single-center, randomized, double-blind, placebo controlled clinical trial...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29483012/lactate-dehydrogenase-as-a-prognostic-marker-in-neoplastic-meningitis
#20
Bernardo Cacho-Díaz, Nydia A Lorenzana-Mendoza, Gervith Reyes-Soto, Allan Hernández-Estrada, Alejandro Monroy-Sosa, Paola Guraieb-Chahin, David Cantu-de-León
This study aimed to establish the prognostic utility of lactate dehydrogenase (LDH) levels in the cerebrospinal fluid (CSF) of patients with neoplastic meningitis (NM). Patients with a confirmed diagnosis of NM at a cancer referral center were included. Data on demographic and oncological background, clinical symptoms, diagnostic tests, treatment, and survival were analyzed. In total, 119 patients were included, 74% of whom were females. The mean age was 44.2 years at the time of cancer diagnosis and 46.6 years at the time between NM diagnosis...
May 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
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