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https://www.readbyqxmd.com/read/30332974/complications-of-immunoglobulin-therapy-and-implications-for-treatment-of-inflammatory-neuropathy-a-review
#1
Ahmed Abbas, Yusuf A Rajabally
Intravenous immunoglobulin (IVIg) forms a cornerstone of effective treatment for acute and chronic inflammatory neuropathies, with a class I evidence base in Guillain-Barré syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN). It is generally considered to be a safe therapy however there are several recognised complications which are reviewed in this article. Most adverse events are immediate and mild such as headache, fever and nausea although more serious immediate reactions such as anaphylaxis may rarely occur...
October 17, 2018: Current Drug Safety
https://www.readbyqxmd.com/read/30302419/trigeminal-hypertrophic-interstitial-neuropathy-presenting-as-unilateral-proptosis-ptosis-tearing-and-facial-neuralgia
#2
Elizabeth R Duvall, Jennifer Pan, Kim Tien T Dinh, Majd Al Shaarani, Golden Pan, Marlyn P Langford, William A Byrd
Purpose: To show the utility of MRI and histology in diagnosing rare cases of trigeminal hypertrophic interstitial neuropathy (HIN). Observations: A 57-year-old African-American woman presented with a 4-year history of right eye proptosis with tearing, headaches, and worsening right-sided trigeminal neuralgia symptoms and jaw pain. HIV and diabetes tests were negative and thyroid function was normal. MRI identified abnormal thickening of all trigeminal nerve divisions and proptosis secondary to right trigeminal nerve V1 division enlargement...
December 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/30290905/thalidomide-before-and-after-autologous-stem-cell-transplantation-in-recently-diagnosed-multiple-myeloma-hovon-50-long-term-results-from-the-phase-3-randomised-controlled-trial
#3
Niels Wcj van de Donk, Bronno van der Holt, Monique C Minnema, Edo Vellenga, Sandra Croockewit, Marie José Kersten, Peter A von dem Borne, Paula Ypma, Ron Schaafsma, Okke de Weerdt, Saskia K Klein, Michel Delforge, Mark-David Levin, Gerard M Bos, Kon-Siong G Jie, Harm Sinnige, Jules Llm Coenen, Esther G de Waal, Sonja Zweegman, Pieter Sonneveld, Henk M Lokhorst
BACKGROUND: In patients with recently diagnosed multiple myeloma, the HOVON-50 phase 3 trial showed improved event-free survival for thalidomide-containing induction and maintenance regimens (in conjunction with high-dose melphalan and autologous stem cell transplantation [auto-SCT]) after a median of 52 months of follow-up, by comparison with regimens containing classical cytotoxic drugs. In this follow-up analysis, we aimed to determine the long-term effects of thalidomide in induction and maintenance therapy in multiple myeloma...
October 2018: Lancet Haematology
https://www.readbyqxmd.com/read/30271035/profile-of-patients-from-a-neurology-registry-in-resource-poor-rural-northwest-india
#4
Amit Bhardwaj, Ashish Sharma, Girish Kumar, Monika Angra, Sapna S Bhardwaj, Sunil Kumar Raina, Sushant Sharma, Piyush Sharma
Background: The neurology register is based in a tertiary care center in a rural north-west India. The center caters to a predominantly rural population. The present study is based on the data retrieved from this registry over a period of 1 year. Materials and Methods: Details of the patients reporting to the Department of Neurology are entered in a registry. For the purpose of this study, 1-year data (from August 1, 2013, to July 31, 2014) of patients (with complete information and final diagnosis) were analyzed...
October 2018: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/30268100/cases-of-visual-impairment-caused-by-cerebral-venous-sinus-occlusion-induced-intracranial-hypertension-in-the-absence-of-headache
#5
Tongtao Zhao, Gang Wang, Jiaman Dai, Yong Liu, Yi Wang, Shiying Li
BACKGROUND: Cerebral venous sinus thrombosis or stenosis (here collectively referred to as cerebral venous sinus occlusion, CVSO) can cause chronically-elevated intracranial pressure (ICP). Patients may have no neurological symptoms other than visual impairment, secondary to bilateral papilledema. Correctly recognizing these conditions, through proper ophthalmological examination and brain imaging, is very important to avoid delayed diagnosis and treatment. CASE PRESENTATION: We report a case series of 3 patients with chronic CVSO, who were admitted to an ophthalmological department in Chongqing, China, from 2015 March to 2017 February...
September 29, 2018: BMC Neurology
https://www.readbyqxmd.com/read/30237691/sleep-disturbances-in-diabetic-peripheral-neuropathy-patients-a-clinical-and-polysomnographic-study
#6
Wafik Said Bahnasy, Yasser Abo Elfotoh El-Heneedy, Ehab Ahmed Shawky El-Seidy, Nema Ata Allah Labib, Ibrahim Salah Eldeen Ibrahim
Background: Disordered sleep breathing is a common complication of diabetic peripheral neuropathy (DPN) manifested by excessive daytime sleepiness, morning headache, morning dizziness, cognitive decline, and mood changes. Methods: This study was performed on 30 non-obese type 2 diabetic patients; 20 with clinically evident DPN and 10 without. Ten age-, sex-, and body mass index-matched healthy control subjects were also included. Patients and control were subjected to history taking, neurological examination, glycated hemoglobin, and clinical assessment of the sensori-motor manifestations by the neuropathy symptom score and neuropathy disability score...
2018: The Egyptian journal of neurology, psychiatry and neurosurgery
https://www.readbyqxmd.com/read/30232672/atypical-clinical-manifestations-of-miller-fisher-syndrome
#7
Jae Ho Jung, Eun Hye Oh, Jin-Hong Shin, Dae-Seong Kim, Seo-Young Choi, Kwang-Dong Choi, Jae-Hwan Choi
Miller Fisher syndrome (MFS) is characterized by a clinical triad of ophthalmoplegia, ataxia, and areflexia, and is closely associated with serum anti-GQ1b antibody. Although the clinical triad is the cardinal diagnostic clue, a variety of other symptoms and signs beyond the triad have been reported. To elucidate the frequency and characteristics of atypical clinical manifestations of MFS, we recruited 38 patients with MFS and evaluated the symptoms or signs beyond the classic triad. Eleven (29%) of 38 patients had atypical clinical manifestations of MFS such as headache (n = 6), delayed facial palsy (n = 3), divergence insufficiency (n = 2), and taste impairment (n = 2)...
September 19, 2018: Neurological Sciences
https://www.readbyqxmd.com/read/30215116/neurological-symptoms-in-hypophosphatasia
#8
J M Colazo, J R Hu, K M Dahir, J H Simmons
Hypophosphatasia (HPP) typically manifests with fractures, tooth loss, and muscle pain. Although mental health diagnoses and neurological symptoms have not been previously well documented in HPP, they occur commonly. The recognition of non-traditional symptoms may improve patient satisfaction, preempt costly evaluation and misdiagnosis, and lead to further treatment options. INTRODUCTION: Hypophosphatasia (HPP) is an inborn error of metabolism due to deficiency of tissue non-specific alkaline phosphatase (TNSALP)...
September 13, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/30190242/first-presentation-with-psychotic-behavior-to-the-emergency-department-meningitis-or-not-that-is-the-question
#9
Abdullah E Laher, Yousef Etlouba, Muhammed Moolla, Feroza Motara, Nazeema Ariefdien
INTRODUCTION: Meningitis is a potentially life threatening medical emergency. Psychotic behavior may be a presenting feature in patients with meningitis. We aimed to determine the value of various clinical and laboratory features at ruling-out meningitis in the patient presenting with a first-episode of psychotic behavior. METHODS: Medical records of 159 subjects presenting to a tertiary academic hospital over a 6-month period with one or more psychotic features for the first time were prospectively gathered...
November 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/30174689/evaluation-of-adverse-drug-reaction-profile-of-drugs-used-as-first-line-antiretroviral-therapy
#10
Mukta N Chowta, Priyanka Kamath, John T Ramapuram, K Ashok Shenoy, Sanjay Hadigal
Background and Objectives: The objective was to study the adverse drug reaction (ADR) profile in HIV patients receiving first-line antiretroviral therapy. Methods: This was a prospective, observational study that included 171 HIV patients with a follow-up at six months. Demographic details, medical history, details of HIV infection including most recent CD4 count, details of antiretroviral therapy, and other concomitant medication were recorded. Adverse drug reactions were elicited by reviewing patient records and also by interviewing the patient/attendants directly...
2018: Interdisciplinary Perspectives on Infectious Diseases
https://www.readbyqxmd.com/read/30123591/a-case-report-on-chikungunya-virus-associated-encephalomyelitis
#11
Harsh Khatri, Heli Shah, Dhara Roy, Kaushalendra Mani Tripathi
Chikungunya is a rerising alphavirus infection that has resulted from enhanced vector competence. Alphaviruses are divided into arthritogenic viruses (old world) and encephalitogenic viruses (new world) including equine encephalitis viruses. Chikungunya is a dengue-like illness characterized by acute febrile polyarthralgia, arthritis, malaise, body ache, rash, headache, and nausea. The illness is self-limiting. The neurological manifestations are uncommon and incorporate meningoencephalitis, myelitis, Guillain-Barre syndrome, cranial nerve palsies, myelopathy, and neuropathy; MRI abnormalities in patients with encephalopathy from India have been reported in the form of multiple punctuate white matter lesions that are more prominent on diffusion-weighted MRI than on T2 or T1...
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/30098921/sleep-quality-and-psychosocial-characteristics-of-patients-with-painful-post-traumatic-trigeminal-neuropathies
#12
Eduardo Vazquez-Delgado, Marta Viaplana-Gutierrez, Charles Carlson, Rui Figueiredo, Eduard Valmaseda-Castellon
OBJECTIVES: The aim of this study was to explore how pain and psychological distress influence the sleep quality of patients with painful post-traumatic trigeminal neuropathy (PPTN). STUDY DESIGN: Thirty-two patients with a diagnosis of PPTN according to the International Classification for Headache Disorders of the International Headache Society were enrolled. All patients completed a number of questionnaires that examined sleep quality, psychological distress, and quality of life...
June 12, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/30086430/diagnosis-of-brain-metastases-in-breast-cancer-patients-resulting-from-neurological-symptoms
#13
Bernardo Cacho-Díaz, Héctor Spínola-Maroño, Victor A Arrieta, Martin Granados-García, Talia Wegman-Ostrosky, Laura G Mendoza-Olivas, Mariana Chávez-MacGregor
OBJECTIVES: Breast cancer (BC) is the leading cause of morbidity and mortality. Neurological symptoms are highly feared because they are associated with central nervous system metastases (CNSm). So, we aimed to analyze the association of neurological symptoms with CNSm. PATIENTS & METHODS: Patients with BC referred for a neuro-oncological evaluation at a cancer referral center from June 2012 to December 2017 were included. Demographic, oncological history, comorbidities, clinical symptoms and signs, and their correlation with CNSm were prospectively acquired during consultation in a computerized database...
October 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/30080243/the-greater-occipital-nerve-and-its-spinal-and-brainstem-afferent-projections-a-stereological-and-tract-tracing-study-in-the-rat
#14
Nuria García-Magro, Yasmina B Martin, Pilar Negredo, Carlos Avendaño
The neuromodulation of the greater occipital nerve (GON) has proved effective to treat chronic refractory neurovascular headaches, in particular migraine and cluster headache. Moreover, animal studies have shown convergence of cervical and trigeminal afferents on the same territories of the upper cervical and lower medullary dorsal horn (DH), the so-called trigeminocervical complex (TCC), and recent studies in rat models of migraine and craniofacial neuropathy have shown that GON block or stimulation alter nociceptive processing in TCC...
August 6, 2018: Journal of Comparative Neurology
https://www.readbyqxmd.com/read/30072073/neurologic-complications-of-radiation-therapy
#15
REVIEW
Shyam K Tanguturi, Brian M Alexander
Cranial radiation therapy (CRT) is used to treat a wide range of malignant and benign conditions and is associated with a unique set of risks and complications. Early complications from CRT include fatigue, skin reaction, alopecia, headaches, anorexia, nausea/vomiting, exacerbation of neurologic symptoms, serous otitis media, parotitis, and encephalopathy. Delayed complications include pseudoprogression, radiation necrosis, neurocognitive changes, cerebrovascular effects, migrainelike disorders, cataracts, xerophthalmia, optic neuropathy, hearing loss, tinnitus, chronic otitis, endocrinopathy, and secondary malignancy...
August 2018: Neurologic Clinics
https://www.readbyqxmd.com/read/30026995/rhinogenic-optic-neuritis-caused-by-sphenoid-mucocele-with-sinusitis
#16
Sasitorn Siritho, Weerachai Tantinikorn, Paithoon Wichiwaniwate, Krit Pongpirul
A 59-year-old male who presented with a nonspecific headache at the vertex, resembling retrobulbar optic neuritis, was treated as such but did not show any improvement. Although optic nerve compression from sphenoid mucocele was finally discovered, the delayed diagnosis and improper treatment led to a permanent visual loss. Optic neuritis could be caused by a common problem, "mucocele/sinusitis," but might be easily overlooked in general practice. Rhinogenic optic neuropathy should, therefore, be considered in every case of optic neuritis whenever atypical presentation occurs or is unresponsive to high-dose steroid treatment...
2018: Case Reports in Radiology
https://www.readbyqxmd.com/read/30014839/case-series-of-severe-neurologic-sequelae-of-ebola-virus-disease-during-epidemic-sierra-leone
#17
Patrick J Howlett, Anna R Walder, Durodami R Lisk, Felicity Fitzgerald, Stephen Sevalie, Marta Lado, Abdul N'jai, Colin S Brown, Foday Sahr, Foday Sesay, Jonathon M Read, Paul J Steptoe, Nicholas A V Beare, Reena Dwivedi, Marylou Solbrig, Gibrilla F Deen, Tom Solomon, Malcolm G Semple, Janet T Scott
We describe a case series of 35 Ebola virus disease (EVD) survivors during the epidemic in West Africa who had neurologic and accompanying psychiatric sequelae. Survivors meeting neurologic criteria were invited from a cohort of 361 EVD survivors to attend a preliminary clinic. Those whose severe neurologic features were documented in the preliminary clinic were referred for specialist neurologic evaluation, ophthalmologic examination, and psychiatric assessment. Of 35 survivors with neurologic sequelae, 13 had migraine headache, 2 stroke, 2 peripheral sensory neuropathy, and 2 peripheral nerve lesions...
August 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/30002929/neuropsychiatric-involvement-in-juvenile-onset-systemic-lupus-erythematosus
#18
Mohammad-Amin Khajezadeh, Gholamreza Zamani, Bobak Moazzami, Zahra Nagahi, Mahdie Mousavi-Torshizi, Vahid Ziaee
Objective: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by multisystem involvement, including the nervous system. In the present study, we aimed to assess neuropsychiatric manifestations in juvenile-onset systemic lupus erythematosus (JSLE) in Iran. Methods: One hundred and forty-six pediatric onset patients with SLE who had registered in our pediatric rheumatology database were evaluated prospectively and cross sectionally within 2013-2015...
2018: Neurology Research International
https://www.readbyqxmd.com/read/30001923/oral-fingolimod-for-chronic-inflammatory-demyelinating-polyradiculoneuropathy-forcidp-trial-a-double-blind-multicentre-randomised-controlled-trial
#19
Richard Hughes, Marinos C Dalakas, Ingemar Merkies, Norman Latov, Jean-Marc Léger, Eduardo Nobile-Orazio, Gen Sobue, Angela Genge, David Cornblath, Martin Merschhemke, Carolyn Marie Ervin, Catherine Agoropoulou, Hans-Peter Hartung
BACKGROUND: Fingolimod is approved for the treatment of relapsing-remitting multiple sclerosis and was effective in experimental autoimmune neuritis in rats, a possible model for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). We aimed to evaluate the efficacy of fingolimod in delaying disability progression in patients with CIDP who withdrew from currently effective treatments (intravenous immunoglobulin [IVIg] or corticosteroids). METHODS: This double-blind, multicentre, randomised, placebo-controlled, parallel-group, event-driven study was done at 48 neurology centres in Australia, Canada, Israel, Japan, the USA, and nine countries in Europe...
August 2018: Lancet Neurology
https://www.readbyqxmd.com/read/30001820/clinical-manifestations-and-location-of-brain-metastases-as-prognostic-markers
#20
Bernardo Cacho-Díaz, Nydia A Lorenzana-Mendoza, J Danaé Chávez-Hernandez, Alberto González-Aguilar, Gervith Reyes-Soto, Ángel Herrera-Gómez
BACKGROUND: Brain metastases (BM) are a frequent complication of cancer and are regularly seen in clinical practice. New treatment modalities are improving survival after diagnosis of BM. However, symptoms are rarely reported and their significance is not well established. The aim of the present study was to investigate neurologic indicators as prognostic markers in patients with brain metastases. PATIENTS AND METHODS: A prospectively acquired database from 2 referral centers was analyzed...
June 12, 2018: Current Problems in Cancer
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