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Human T-lymphotropic virus 1

Rakan Nasreddine, Roland de Wind, Stéphane De Wit, Charlotte Martin
No abstract text is available yet for this article.
January 27, 2019: AIDS
Simon Smith, Darren Russell, Peter Horne, Josh Hanson
Human T-lymphotropic virus type 1 (HTLV-1) is hyperendemic amongst Indigenous Australians living in Central Australia. The epidemiology of the disease is poorly defined in other parts of Australia, despite a high prevalence of classically associated conditions. All HTLV-1 serology tests requested through public health facilities in Far North Queensland (FNQ) from January 1999 to December 2016 were reviewed. The person's age, sex, ethnicity, location, rationale for testing and result were recorded. There were 444 tests performed in 409 people; 217 (53%) were male; 171 (42%) identified as Indigenous Australians...
November 28, 2018: Pathology
Christopher T Haley, Uyen Ngoc Mui, Ramya Vangipuram, Peter L Rady, Stephen K Tyring
In 1964, the first human oncovirus, Epstein-Barr virus (EBV), was identified in Burkitt lymphoma cells. Since then, six other human oncoviruses have been identified: human papillomavirus (HPV), Merkel cell polyomavirus (MCPyV), hepatitis B and C viruses (HBV and HCV), human T-cell lymphotropic virus-1 (HTLV-1), and human herpesvirus-8 (HHV-8). These viruses are causally linked to 12% of all cancers, many of which have mucocutaneous manifestations. Additionally, oncoviruses are associated with multiple benign mucocutaneous diseases...
November 28, 2018: Journal of the American Academy of Dermatology
Uyen Ngoc Mui, Christopher T Haley, Ramya Vangipuram, Stephen K Tyring
In 1964, the first human oncovirus, Epstein-Barr virus (EBV), was identified in Burkitt lymphoma cells. Since then, six other human oncoviruses have been identified: human papillomavirus (HPV), Merkel cell polyomavirus (MCPyV), hepatitis B and C viruses (HBV and HCV), human T-cell lymphotropic virus-1 (HTLV-1), and human herpesvirus-8 (HHV-8). These viruses are causally linked to 12% of all cancers, many of which have mucocutaneous manifestations. Additionally, oncoviruses are associated with many benign mucocutaneous diseases...
November 28, 2018: Journal of the American Academy of Dermatology
Jennifer Tam, Kevin Schwartz, Jay Keystone, Dimitri Dimitrakoudis, Mark Downing, Sigmund Krajden
Central nervous system (CNS) strongyloidiasis is a known but rare form of disseminated infection. The diagnosis is often made postmortem, with only five published cases of an antemortem diagnosis. We report two fatal cases of CNS strongyloidiasis diagnosed antemortem, with Strongyloides stercoralis larvae visualized in the CNS sample in one case. Risk factors for disseminated strongyloidiasis common to both cases included origination from the Caribbean, underlying human T-lymphotropic virus-1 infection, and recent prednisone use...
November 19, 2018: American Journal of Tropical Medicine and Hygiene
Michel Kengne, Dorine Carol Wouado Tsata, Thérèse Ndomgue, Julius Mbekem Nwobegahay
Introduction: Transfusion-transmissible infectious microorganisms including bacteria and viruses are among the greatest threats to blood safety for the recipient. The prevalence and risk factors of HTLV-1/2 and other blood borne infectious diseases were determined among blood donors in Yaounde Central Hospital, Cameroon. Methods: Design: cross sectional study. Setting: The blood bank unit of Yaounde Central Hospital, Cameroon. Subjects: a consecutive sample of 265 apparently healthy adult blood donors...
2018: Pan African Medical Journal
Rajan K Pandey, Rupal Ojha, Nina Chatterjee, Nitesh Upadhyay, Amit Mishra, Vijay K Prajapati
Human T-lymphotropic virus (HTLV), the first human retrovirus has been discovered which is known to cause the age-old assassinating disease HTLV-1 associated myelopathy. Cancer caused by this virus is adult T cell leukemia/lymphoma which targets 10-20 million throughout the world. The effect of this virus extends to the fact that it causes chronic disease to the spinal cord resulting in loss of sensation and further causes blood cancer. So, to overcome the complications, we designed a subunit vaccine by the assimilation of B-cell, cytotoxic T-lymphocyte , and helper T-lymphocyte epitopes...
October 28, 2018: Journal of Cellular Physiology
Melanie Caron, Guillaume Besson, Cindy Padilla, Maria Makuwa, Dieudonne Nkoghe, Eric Leroy, Mirdad Kazanji
HTLV-1 infection is considered as highly endemic in central Africa. Thirty years ago, a first epidemiological study was performed in Gabon, central Africa, and revealed that the prevalence varied from 5.0 to 10.5%. To evaluate current distribution of HTLVs in Gabon, 4.381 samples were collected from rural population living in 220 villages distributed within the 9 provinces of country. HTLVs prevalence was determined using two ELISA tests and positive results were confirmed by Western Blot. The overall HTLV-1 seroprevalence was of 7...
October 2018: PLoS Neglected Tropical Diseases
Mohadeseh Zarei-Ghobadi, Sayed-Hamidreza Mozhgani, Fariba Dashtestani, Amir Yadegari, Fatemeh Hakimian, Mehdi Norouzi, Hedayatollah Ghourchian
Carbon dots and Fe3 O4 @Au were synthesized to develop a new biosensor to detect DNA target. We investigated the photoluminescence property of carbon dots (CDs) in the presence of Fe3 O4 -capped Au (Fe3 O4 @Au). Firstly, we designed two dedicated probes for unique long sequence region of human T-lymphotropic virus type 1 genome. One of the probes was covalently bound to the CDs. In the absence of target, CDs-probe was adsorbed on the surface of Fe3 O4 @Au through two possible mechanisms, leading to quenching the fluorescence emission of CDs...
October 22, 2018: Scientific Reports
Anurag Kulkarni, Graham P Taylor, Robert J Klose, Christopher J Schofield, Charles Rm Bangham
It is not understood how the human T cell leukemia virus human T-lymphotropic virus-1 (HTLV-1), a retrovirus, regulates the in vivo balance between transcriptional latency and reactivation. The HTLV-1 proviral plus-strand is typically transcriptionally silent in freshly isolated peripheral blood mononuclear cells from infected individuals, but after short-term ex vivo culture, there is a strong, spontaneous burst of proviral plus-strand transcription. Here, we demonstrate that proviral reactivation in freshly isolated, naturally infected primary CD4+ T cells has 3 key attributes characteristic of an immediate-early gene...
October 18, 2018: JCI Insight
Ingrid Christiane Silva, Bruna Teles Pinheiro, Akim Felipe Santos Nobre, Jaciana Lima Coelho, Cássia Cristine Costa Pereira, Louise de Souza Canto Ferreira, Camila Pâmela Santos de Almeida, Maria de Nazaré do Socorro de Almeida Viana, Danilo Souza de Almeida, Jairo Ribeiro Falcão, Yago Costa Vasconcelos Dos Santos, Marcos William Leão de Araújo, Mariza da Silva Borges, Lisandra Duarte Nascimento, Lorena Saldanha Valentim, Jorge Simão do Rosario Casseb, Carlos Araújo da Costa, Maísa Silva de Sousa
INTRODUCTION: The spread of the HTLV infection in families living in the metropolitan area of Belém, Pará, Brazil, and the lack of studies in the general population requires studies to better understand its prevalence in the region. METHODS: An anti-HTLV-1/HTLV-2 antibodies test was carried out on random adults in public places in Belém between November 2014 and November 2015. A proviral DNA test detected if the person was infected, and then a clinical evaluation and an intrafamilial investigation were carried out...
October 11, 2018: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
Delia Doreen Djuicy, Augustin Mouinga-Ondémé, Olivier Cassar, Jill-Léa Ramassamy, Antony Idam Mamimandjiami, Rodrigue Bikangui, Arnaud Fontanet, Antoine Gessain
BACKGROUND: Human T-Lymphotropic Virus type 1 (HTLV-1) is a human oncoretrovirus that infects at least 5 to 10 million people worldwide and is associated with severe diseases. Africa appears as the largest HTLV-1 endemic area. However, the risk factors for the acquisition of HTLV-1 remain poorly understood in Central Africa. METHODS: We conducted an epidemiological survey between 2013 and 2017, in rural areas of 6 provinces of Gabon, in a rainforest environment...
October 2018: PLoS Neglected Tropical Diseases
Naoto Suzuki, Takeshi Yoshida, Hiroaki Takeuchi, Ryuta Sakuma, Sayaka Sukegawa, Shoji Yamaoka
Lentiviral vectors are a valuable tool to deliver exogenous genes for stable expression in cells. While much progress has been made in processing lentiviral vector-containing culture medium, it remains to be explored how the production of lentiviral vector from producer cells can be increased. We initially found that co-expression of the SPRY domain-containing SOCS box protein 1 (SPSB1) promotes the production of human immunodeficiency virus type 1 (HIV-1) and lentiviral vector with increased expression of the Gag and envelope proteins and activation of the HIV-1 LTR and CMV promoter...
October 11, 2018: Scientific Reports
Jocelyn Turpin, David Yurick, Georges Khoury, Hai Pham, Stephen Locarnini, Anat Melamed, Aviva Witkover, Kim Wilson, Damian Purcell, Charles R M Bangham, Lloyd Einsiedel
The prevalence of human T-cell lymphotropic virus type 1 (HTLV-1) and hepatitis B virus (HBV) coinfection is high in certain Indigenous Australian populations, but its impact on HTLV-1 has not been described. We compared 2 groups of Indigenous adults infected with HTLV-1, either alone or coinfected with HBV. The 2 groups had a similar HTLV-1 proviral load, but there was a significant increase in clonal expansion of HTLV-1-infected lymphocytes in coinfected asymptomatic individuals. The degree of clonal expansion was correlated with the titer of HBV surface antigen...
October 11, 2018: Journal of Infectious Diseases
Takashi Ishida
Patients with adult T-cell leukemia/lymphoma (ATL), which is caused by human T-cell lymphotropic virus type 1, exhibit an extremely poor prognosis. ATL was first reported in 1977 in Japan as a distinct T-cell neoplasm, and its basic and clinical research have been led by Japanese investigators. This study aims to review the scenario since the discovery of ATL/HTLV-1 to the current status of ATL research and medicine and to consider its future directions.
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Roberta Vilela Lopes Koyama, Gilberto Toshimitsu Yoshikawa, Satomi Fujihara, George Alberto da Silva Dias, Rodrigo Rodrigues Virgolino, Anderson Raiol Rodrigues, Rita Medeiros, Juarez Antônio Simões Quaresma, Hellen Thaís Fuzii
This was a cross-sectional prospective study. We performed a multivariate statistical analysis of the neurological signs and symptoms of patients infected with human T cell lymphotropic virus type 1 (HTLV-1) in an attempt to separate them into distinct groups and identify clinical-neurological manifestations that could differentiate the various profiles. The study was performed in the city of Belém (state of Pará), located in the Amazon region of Brazil, from 2014 to 2016. We determined muscle strength and tone, reflexes, sensations, sphincter function, gait, and the Expanded Disability Status Scale score among individuals with HTLV-I...
October 5, 2018: Journal of Neurovirology
Joelma Nascimento De Souza, Barbara Nascimento Rocha Ribeiro Soares, Luana Leandro Goes, Cintia de Souza Lima, Nilo Manoel Pereira Vieira Barreto, Beatriz Soares Jacobina, Noilson Gonçalves, Marcia Cristina Aquino Teixeira, Bernardo Galvão-Castro, Maria Fernanda Rios Grassi, Neci Matos Soares
Strongyloides stercoralis is the main etiological agent of human strongyloidiasis. Severe strongyloidiasis is commonly associated to alcoholism, corticostereoid use, and human T cell lymphotropic virus type 1 (HTLV-1) coinfection. Herein, we report a case of a 13-year-old boy coinfected with S. stercoralis and HTLV-1, excreting several parasitic forms in the stool. The parasitological examination of his feces showed a large amount of filariform (about 3,000 larvae per gram of feces) and rhabditiform larvae (about 2,000 larvae per gram of feces)...
October 1, 2018: American Journal of Tropical Medicine and Hygiene
Angela Wilson, Deborah Fearon
Few published studies are available describing the prevalence of paediatric strongyloidiasis in endemic areas within Australia. This literature review and exploratory clinical audit presents the first seroprevalence data for paediatric patients in Central Australia. A total of 16.1% (30/186) of paediatric inpatients tested for Strongyloides stercoralis in 2016 were seropositive (95% CI: 11.5% to 22.1%). Eosinophilia of unknown aetiology was the most common indication for testing (91.9%). Seropositive patients were significantly more likely to reside in communities outside of Alice Springs ( p = 0...
June 13, 2018: Tropical Medicine and Infectious Disease
Júlia Fonseca de Morais Caporali, Ludimila Labanca, Kyonis Rodrigues Florentino, Bárbara Oliveira Souza, Denise Utsch Gonçalves
BACKGROUND: The vestibular evoked myogenic potential triggered by galvanic vestibular stimulation (galvanic-VEMP) has been used to assess the function of the vestibulospinal motor tract and is a candidate biomarker to predict and monitor the human T-cell lymphotropic virus type 1 (HTLV-1) associated myelopathy (HAM). This study determined the agreement and reliability of this exam. METHODS: Galvanic-VEMP was performed in 96 participants, of which 24 patients presented HAM, 27 HTLV-1-asymptomatic carriers, and 45 HTLV-1-negative asymptomatic controls...
2018: PloS One
Juliana Echevarria-Lima, Denise de Abreu Pereira, Thais Silva de Oliveira, Otávio de Melo Espíndola, Marco Antonio Lima, Ana Cláudia Celestino Leite, Vanessa Sandim, Clarissa Rodrigues Nascimento, Dario E Kalume, Russolina B Zingali
Human T-cell lymphotropic virus type-1 (HTLV-1) is the etiological agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The endothelial breakdown and migration of leukocytes, including monocytes, to the spinal cord are involved in HAM/TSP development. Monocytes from HTLV-1-infected individuals exhibit important functional differences when compared to cells from uninfected donors. Using proteomic shot gun strategy, performed by nanoACQUITY-UPLC system, we analyzed monocytes isolated from peripheral blood of asymptomatic carriers (AC), HAM/TSP and uninfected individuals...
September 25, 2018: Scientific Reports
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