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Human T-lymphotropic virus 1

Preetha D Kamath, Jennifer L Abrahams, Jeong Hee Cho-Vega
Human T-cell lymphotropic virus-1 (HTLV-1) is a retrovirus that causes adult T-cell leukemia/lymphoma (ATLL), an aggressive malignancy of CD4+ T-lymphocytes. This virus is endemic to the Caribbean, Japan, and regions of South America and Africa.[1] In Miami/ South Florida, whose population is enriched with immigrants from HTLV-1 endemic areas, we have identified multiple cases of ATLL. [2] This article is protected by copyright. All rights reserved.
August 9, 2018: Journal of Cutaneous Pathology
Tomoo Sato, Naoko Yagishita, Keiko Tamaki, Eisuke Inoue, Daisuke Hasegawa, Misako Nagasaka, Hiroko Suzuki, Natsumi Araya, Ariella Coler-Reilly, Yasuhiro Hasegawa, Yoshio Tsuboi, Ayako Takata, Yoshihisa Yamano
Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a rare chronic neuroinflammatory disease. While the disease usually progresses slowly without remission, there is a subgroup of patients with rapid progression and another subgroup with very slow progression. However, there have been no reports to date that have successfully determined the criteria to differentiate these subgroups. Therefore, we initially conducted a statistical modeling analysis to explore representative patterns of disease progression using data from our nationwide HAM/TSP patient registration system ("HAM-net")...
2018: Frontiers in Microbiology
Noriaki Kawano, Shuro Yoshida, Sayaka Kawano, Takuro Kuriyama, Yoshihiro Tahara, Atsushi Toyofuku, Tatsuya Manabe, Atsushi Doi, Soushi Terasaka, Kiyoshi Yamashita, Yuji Ueda, Hidenobu Ochiai, Kousuke Marutsuka, Yoshihisa Yamano, Kazuya Shimoda, Ikuo Kikuchi
Because there are limited clinical reports on the impact of human T-lymphotropic virus type 1 (HTLV-1) on organ transplantation, its effects on the development of adult T-cell leukemia-lymphoma (ATL), post-transplantation lymphoproliferative disorder (PTLD) and HTLV-1-associated myelopathy (HAM) or atypical HAM after organ transplantation remain unclear.We retrospectively analyzed the impact of HTLV-1 in 54 allogeneic hematopoietic stem cell transplantation (allo-HSCT) cases and 31 renal transplantation cases between January 2006 and December 2016...
August 8, 2018: Journal of Clinical and Experimental Hematopathology: JCEH
Mona Kabiri, Mojtaba Sankian, Mitra Hosseinpour, Mohsen Tafaghodi
This study reports on the immunogenicity assessment of a novel chimeric peptide vaccine including Tax, gp21, gp46, and gag immunodominant epitopes of human T-cell lymphotropic virus type 1 (HTLV-1) to induce immunity against HTLV-1 after subcutaneous (SC) or intranasal administration in a mice model. Additionally, to elevate the efficacy of the HTLV-1 vaccine, the chimera was physically mixed with monophosphoryl lipid A (MPLA) or ISCOMATRIX (IMX) adjuvants. For this purpose, the ISCOMATRIX with a size range of 40 to 60 nm were prepared using lipid film hydration method...
July 31, 2018: International Journal of Pharmaceutics
Miho Hachiman, Makoto Yoshimitsu, Chibueze Ezinne, Ayako Kuroki, Tomohiro Kozako, Naomichi Arima
Despite the efficacy of combination chemotherapy with arsenic trioxide (ATO), interferon α (IFN) and zidovudine (AZT) for adult T cell leukemia/lymphoma (ATL), the precise mechanism underlying this combination treatment effect is unknown. In the present study, ATO/IFN/AZT was examined in an ATL leukemic cell line (S1T, non-Tax expressing), a human T-lymphotropic virus 1 (HTLV-1)-infected cell line (MT2, Tax-expressing) and primary ATL cells from patients with acute and chronic ATL. IFN/AZT marginally inhibited MT2 cell proliferation, but substantially inhibited S1T cell proliferation...
July 2018: Oncology Letters
Augustine Okechukwu Udeze, Mutiat B Odebisi-Omokanye, Adedayo Faneye, Babatunde Adebiyi Olusola, Olukunle Ogunsemowo, Cecilia Iwuoha, Victoria Atoyebi
Human T-cell lymphotropic virus types I/II (HTLV-I/II) is endemic in some parts of the world including Nigeria. Reported prevalence rates in Nigeria have largely focused on blood donors. This study aims at determining the prevalence of HTLV infection among pregnant women in Ilorin North-central Nigeria. Serum samples from 276 pregnant women who were antenatal clinic attendees at General and Civil Service Hospitals in Ilorin were tested for the presence of HTLV-I/II antibodies using Enzyme Linked Immunosorbent Assay test kits from Diagnostic Automation INC...
July 30, 2018: Journal of Immunoassay & Immunochemistry
Elida Cg Mata, Roberto M Bezerra, Aldo A Proietti Júnior, Luana Ks Pamplona, Lilian O Gomes, Valmir C Corrêa, Jordan Sr Caluff, Geanny S Borges, J Casseb, Lib Kanzaki
Introduction: The human T-cell lymphotropic virus type 1 (HTLV-1) is aetiologically linked to myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T cell leukaemia (ATL) besides other less incident pathologies, while the type 2 has not been definitively linked to any diseases. Objectives: To determine the HTLV-1/2 seroprevalence in two Brazilian communities in northern Brazil. Methods: In 2010 and 2015, HTLV-1/2 serological surveys were carried out in the Oiapoque county at the Brazilian border with French Guiana and in Santa Cruz do Arari, Marajó Island...
July 1, 2018: Journal of Virus Eradication
Anna Kozajda
BACKGROUND: Paper presents the intentional use of biological agents for industrial, diagnostic and research purposes in enterprises in Poland. MATERIAL AND METHODS: The source of data is the National Register of Biological (in Polish KRCB) - the type of the database that gathers data about the intentional use of biological agents at work in Poland. The analysis includes tabular summaries of the data as of December 2017. RESULTS: Notifications were sent by 598 enterprises for: diagnostic - 67...
July 16, 2018: Medycyna Pracy
Sara Thulin Hedberg, Lorraine Eriksson, Maria A Demontis, Paula Mölling, Martin Sundqvist, Graham Taylor, Kerstin Malm, Sören Andersson
BACKGROUND: Human T-lymphotrophic virus (HTLV) types 1 and 2 cause lifelong infection whereby most infected individuals are asymptomatic whilst a minority develop infection-related disease. These latter patients invariably have been found to have high proviral load (PVL). Therefore, infected patients are monitored by determining the proportion of lymphocytes that are infected with HTLV-1/2. An increase in PVL has been shown to represent an increasing risk of developing HTLV-associated diseases...
October 2018: Journal of Virological Methods
Ludimila Labanca, Júlia Fonseca de Morais Caporali, Sirley Alves da Silva Carvalho, José Roberto Lambertucci, Anna Bárbara de Freitas Carneiro Proietti, Luiz Cláudio Ferreira Romanelli, Paul Avan, Fabrice Giraudet, Bárbara Oliveira Souza, Kyonis Rodrigues Florentino, Denise Utsch Gonçalves
BACKGROUND: Vestibular-evoked myogenic potential triggered by galvanic vestibular stimulation (galvanic-VEMP) evaluates the motor spinal cord and identifies subclinical myelopathies. We used galvanic-VEMP to compare spinal cord function in individuals infected with human T-cell lymphotropic virus type 1 (HTLV-1) from asymptomatic status to HTLV-1-associated myelopathy (HAM). METHODOLOGY/PRINCIPAL FINDINGS: This cross-sectional study with 122 individuals included 26 HTLV-1-asymptomatic carriers, 26 individuals with possible HAM, 25 individuals with HAM, and 45 HTLV-1-seronegative individuals (controls)...
2018: PloS One
Sayed-Hamidreza Mozhgani, Hamid Reza Jahantigh, Houshang Rafatpanah, Narges Valizadeh, Asadollah Mohammadi, Samira Basharkhah, Seyed Abdolrahim Rezaee
HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic neuroinflammatory disease related to human T lymphotropic virus type 1 (HTLV-1) infection. Interferon type III (IFN-λ), which includes IL28, IL29, and IL28R, and affects the outcome of viral infections, might be complicated in the progression of HAM/TSP. Here, we investigated the host-virus interactions in the manifestation of HAM/TSP, using IL28B, IL29, IL28R, HTLV-1 Tax, HTLV-1 basic leucine zipper factor (HBZ), and proviral load (PVL)...
July 10, 2018: Neuro-degenerative Diseases
Pedro Augusto Sampaio Rocha-Filho, Liliana Raulino Goncalves
INTRODUCTION: Studies have linked human T-cell lymphotropic virus type-1 (HTLV-1) to psychiatric disease. METHODS: Patients with HTLV-1 were compared to patients seen by family doctors using a semi-structured questionnaire and the Hospital Anxiety and Depression Scale. RESULTS: Participants with (n=58) and without (n=340) HTLV were compared. Anxiety and depression were associated with greater age, being a woman, spastic paraparesis (depression: PR=4...
May 2018: Revista da Sociedade Brasileira de Medicina Tropical
Selim Farès, Rabih Hage, Jean Pegliasco, Samy Chraibi, Harold Merle
Adult T-cell Leukemia/Lymphoma (ATLL) is a sight- and life-threatening complication of human T-cell lymphotropic virus type 1 (HTLV-1) infection. Ophthalmic manifestations include uveitis, optic nerve oedema, retinal vasculitis, and lymphomatous infiltration. Orbital lesions are rare. We report the case of an orbital tumor revealing systemic ATLL in a 45-year-old Dominican patient who died despite treatment. Apart from late-grade cutaneous T-cell lymphoma, ATLL is the only T-lymphoma to develop in the orbit...
July 2, 2018: American Journal of Tropical Medicine and Hygiene
Elenaé Vázquez-Ulloa, Marcela Lizano, Marika Sjöqvist, Leslie Olmedo-Nieva, Adriana Contreras-Paredes
The Notch pathway is a conserved signaling pathway and a form of direct cell-cell communication related to many biological processes during development and adulthood. Deregulation of the Notch pathway is involved in many diseases, including cancer. Almost 20% of all cancer cases have an infectious etiology, with viruses responsible for at least 1.5 million new cancer cases per year. Seven groups of viruses have been classified as oncogenic: hepatitis B and C viruses (HBV and HCV respectively), Epstein-Barr virus (EBV), Kaposi sarcoma-associated herpesvirus (KSHV), human T lymphotropic virus (HTLV-1), human papillomavirus (HPV), and Merkel cell polyomavirus (MCPyV)...
June 28, 2018: Reviews in Medical Virology
Li-Juan Wang, Ming Ren, Li Liang, Chun-Yang Zhang
Human T-lymphotropic virus type II (HTLV-II) is an important type-C retrovirus, closely related to a variety of human diseases. Here, we demonstrate for the first time the controllable fabrication of bio-bar codes for dendritically amplified sensing of low-abundant HTLV-II DNA by the integration of terminal deoxynucleotidyl transferase (TdT)-catalyzed template-free polymerization extension with bio-bar-code amplification (BCA). HTLV-II DNA hybridizes with magnetic microparticle (MMP)-modified capture probe 1, forming a stable DNA duplex with a protruding 3'-hydroxylated sequence which may function as a primer to initiate the TdT-catalyzed first-step polymerization extension for the generation of a poly-thymidine (T) sequence...
June 14, 2018: Chemical Science
Maria Lina Tornesello, Clorinda Annunziata, Anna Lucia Tornesello, Luigi Buonaguro, Franco Maria Buonaguro
Viral oncogenesis is a multistep process largely depending on the complex interplay between viruses and host factors. The oncoviruses are capable of subverting the cell signaling machinery and metabolic pathways and exploit them for infection, replication, and persistence. Several viral oncoproteins are able to functionally inactivate the tumor suppressor p53, causing deregulated expression of many genes orchestrated by p53, such as those involved in apoptosis, DNA stability, and cell proliferation. The Epstein⁻Barr virus (EBV) BZLF1, the high-risk human papillomavirus (HPV) E6, and the hepatitis C virus (HCV) NS5 proteins have shown to directly bind to and degrade p53...
June 22, 2018: Cancers
Ayako Masaki, Takashi Ishida, Susumu Suzuki, Asahi Ito, Tomoko Narita, Shiori Kinoshita, Masaki Ri, Shigeru Kusumoto, Hirokazu Komatsu, Hiroshi Inagaki, Ryuzo Ueda, Shinsuke Iida
Adult T-cell leukemia/lymphoma (ATL) is caused by Human T-cell lymphotropic/leukemia virus type 1 (HTLV-1), and a higher HTLV-1 provirus load in PBMC is a risk factor for ATL development. Here, we document a significant inverse correlation between the function of HTLV-1 Tax-specific CTL (Tax-CTL), as assessed by ex vivo cytokine production in response to cognate peptide, and the HTLV-1 provirus load in PBMC in both HTLV-1 asymptomatic carriers (AC) (Spearman rank correlation coefficient [Rs] = -0.494, P = ...
May 29, 2018: Cancer Science
Ivonizete Pires Ribeiro, Aline Garcia Kozlowski, Marcia Alves Dias de Matos, Ágabo Macedo da Costa E Silva, Megmar Aparecida Dos Santos Carneiro, Ana Carolina Paulo Vicente, Regina Maria Bringel Martins
Independent epidemiology for respective human T-cell lymphotropic virus (HTLV) types 1 and 2 is little known in blood donors in Brazil, where screening for HTLV-1/2 is mandatory at blood banks, but no testing to confirm/differentiate these viruses. Therefore, this study aims to assess the prevalence of HTLV-1 and -2 in a first-time blood donor population in Northeastern Brazil and to carry out molecular characterization of respective isolates. A cross-sectional study was conducted at the State Blood Bank in Piauí...
May 24, 2018: Journal of Medical Virology
Varun K Sharma, Vittoria Raimondi, Katia Ruggero, Cynthia A Pise-Masison, Ilaria Cavallari, Micol Silic-Benussi, Vincenzo Ciminale, Donna M D'Agostino
Human T-lymphotropic virus 1 (HTLV-1) immortalizes T-cells and is the causative agent of adult T-cell leukemia/lymphoma (ATLL). HTLV-1 replication and transformation are governed by multiple interactions between viral regulatory proteins and host cell factors that remain to be fully elucidated. The present study investigated the impact of HTLV-1 infection on the expression of miR-34a, a microRNA whose expression is downregulated in many types of cancer. Results of RT-PCR assays showed that five out of six HTLV-1-positive cell lines expressed higher levels of miR-34a compared to normal PBMC or purified CD4+ T-cells...
2018: Frontiers in Microbiology
Aubaneide Batista Guerra, Leonardo Quintão Siravenha, Rogério Valois Laurentino, Rosimar Neris Martins Feitosa, Vânia Nakauth Azevedo, Antonio Carlos Rosário Vallinoto, Ricardo Ishak, Luiz Fernando Almeida Machado
BACKGROUND: Prenatal tests are important for prevention of vertical transmission of various infectious agents. The objective of this study was to describe the prevalence of human immunodeficiency virus (HIV), human T-lymphotropic virus (HTLV), hepatitis B virus (HBV), cytomegalovirus (CMV), rubella virus and vaccination coverage against HBV in pregnant adolescents who received care in the city of Belém, Pará, Brazil. METHODS: A cross-sectional study was performed with 324 pregnant adolescents from 2009 to 2010...
May 16, 2018: BMC Pregnancy and Childbirth
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