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Human T-lymphotropic virus 1

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https://www.readbyqxmd.com/read/30312301/risk-factors-for-htlv-1-infection-in-central-africa-a-rural-population-based-survey-in-gabon
#1
Delia Doreen Djuicy, Augustin Mouinga-Ondémé, Olivier Cassar, Jill-Léa Ramassamy, Antony Idam Mamimandjiami, Rodrigue Bikangui, Arnaud Fontanet, Antoine Gessain
BACKGROUND: Human T-Lymphotropic Virus type 1 (HTLV-1) is a human oncoretrovirus that infects at least 5 to 10 million people worldwide and is associated with severe diseases. Africa appears as the largest HTLV-1 endemic area. However, the risk factors for the acquisition of HTLV-1 remain poorly understood in Central Africa. METHODS: We conducted an epidemiological survey between 2013 and 2017, in rural areas of 6 provinces of Gabon, in a rainforest environment...
October 12, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/30310119/robust-enhancement-of-lentivirus-production-by-promoter-activation
#2
Naoto Suzuki, Takeshi Yoshida, Hiroaki Takeuchi, Ryuta Sakuma, Sayaka Sukegawa, Shoji Yamaoka
Lentiviral vectors are a valuable tool to deliver exogenous genes for stable expression in cells. While much progress has been made in processing lentiviral vector-containing culture medium, it remains to be explored how the production of lentiviral vector from producer cells can be increased. We initially found that co-expression of the SPRY domain-containing SOCS box protein 1 (SPSB1) promotes the production of human immunodeficiency virus type 1 (HIV-1) and lentiviral vector with increased expression of the Gag and envelope proteins and activation of the HIV-1 LTR and CMV promoter...
October 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30307560/impact-of-hepatitis-b-virus-coinfection-on-human-t-lymphotropic-virus-type-1-clonality-in-an-indigenous-population-of-central-australia
#3
Jocelyn Turpin, David Yurick, Georges Khoury, Hai Pham, Stephen Locarnini, Anat Melamed, Aviva Witkover, Kim Wilson, Damian Purcell, Charles R M Bangham, Lloyd Einsiedel
The prevalence of human T-cell lymphotropic virus type 1 (HTLV-1) and hepatitis B virus (HBV) coinfection is high in certain Indigenous Australian populations, but its impact on HTLV-1 has not been described. We compared 2 groups of Indigenous adults infected with HTLV-1, either alone or coinfected with HBV. The 2 groups had a similar HTLV-1 proviral load, but there was a significant increase in clonal expansion of HTLV-1-infected lymphocytes in coinfected asymptomatic individuals. The degree of clonal expansion was correlated with the titer of HBV surface antigen...
October 11, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/30305519/-current-status-and-future-directions-of-atl
#4
Takashi Ishida
Patients with adult T-cell leukemia/lymphoma (ATL), which is caused by human T-cell lymphotropic virus type 1, exhibit an extremely poor prognosis. ATL was first reported in 1977 in Japan as a distinct T-cell neoplasm, and its basic and clinical research have been led by Japanese investigators. This study aims to review the scenario since the discovery of ATL/HTLV-1 to the current status of ATL research and medicine and to consider its future directions.
2018: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/30291566/incomplete-myelopathy-and-human-t-cell-lymphotropic-virus-type-1-htlv-1
#5
Roberta Vilela Lopes Koyama, Gilberto Toshimitsu Yoshikawa, Satomi Fujihara, George Alberto da Silva Dias, Rodrigo Rodrigues Virgolino, Anderson Raiol Rodrigues, Rita Medeiros, Juarez Antônio Simões Quaresma, Hellen Thaís Fuzii
This was a cross-sectional prospective study. We performed a multivariate statistical analysis of the neurological signs and symptoms of patients infected with human T cell lymphotropic virus type 1 (HTLV-1) in an attempt to separate them into distinct groups and identify clinical-neurological manifestations that could differentiate the various profiles. The study was performed in the city of Belém (state of Pará), located in the Amazon region of Brazil, from 2014 to 2016. We determined muscle strength and tone, reflexes, sensations, sphincter function, gait, and the Expanded Disability Status Scale score among individuals with HTLV-I...
October 5, 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/30277207/case-report-strongyloides-stercoralis-hyperinfection-in-a-patient-with-htlv-1-a-case-report-of-an-infection-with-filariform-and-rhabditiform-larvae-eggs-and-free-living-adult-females
#6
Joelma Nascimento De Souza, Barbara Nascimento Rocha Ribeiro Soares, Luana Leandro Goes, Cintia de Souza Lima, Nilo Manoel Pereira Vieira Barreto, Beatriz Soares Jacobina, Noilson Gonçalves, Marcia Cristina Aquino Teixeira, Bernardo Galvão-Castro, Maria Fernanda Rios Grassi, Neci Matos Soares
Strongyloides stercoralis is the main etiological agent of human strongyloidiasis. Severe strongyloidiasis is commonly associated to alcoholism, corticostereoid use, and human T cell lymphotropic virus type 1 (HTLV-1) coinfection. Herein, we report a case of a 13-year-old boy coinfected with S. stercoralis and HTLV-1, excreting several parasitic forms in the stool. The parasitological examination of his feces showed a large amount of filariform (about 3,000 larvae per gram of feces) and rhabditiform larvae (about 2,000 larvae per gram of feces)...
October 1, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/30274460/paediatric-strongyloidiasis-in-central-australia
#7
Angela Wilson, Deborah Fearon
Few published studies are available describing the prevalence of paediatric strongyloidiasis in endemic areas within Australia. This literature review and exploratory clinical audit presents the first seroprevalence data for paediatric patients in Central Australia. A total of 16.1% (30/186) of paediatric inpatients tested for Strongyloides stercoralis in 2016 were seropositive (95% CI: 11.5% to 22.1%). Eosinophilia of unknown aetiology was the most common indication for testing (91.9%). Seropositive patients were significantly more likely to reside in communities outside of Alice Springs ( p = 0...
June 13, 2018: Tropical Medicine and Infectious Disease
https://www.readbyqxmd.com/read/30261002/intrarater-and-interrater-agreement-and-reliability-of-vestibular-evoked-myogenic-potential-triggered-by-galvanic-vestibular-stimulation-galvanic-vemp-for-htlv-1-associated-myelopathy-testing
#8
Júlia Fonseca de Morais Caporali, Ludimila Labanca, Kyonis Rodrigues Florentino, Bárbara Oliveira Souza, Denise Utsch Gonçalves
BACKGROUND: The vestibular evoked myogenic potential triggered by galvanic vestibular stimulation (galvanic-VEMP) has been used to assess the function of the vestibulospinal motor tract and is a candidate biomarker to predict and monitor the human T-cell lymphotropic virus type 1 (HTLV-1) associated myelopathy (HAM). This study determined the agreement and reliability of this exam. METHODS: Galvanic-VEMP was performed in 96 participants, of which 24 patients presented HAM, 27 HTLV-1-asymptomatic carriers, and 45 HTLV-1-negative asymptomatic controls...
2018: PloS One
https://www.readbyqxmd.com/read/30254298/protein-profile-of-blood-monocytes-is-altered-in-htlv-1-infected-patients-implications-for-ham-tsp-disease
#9
Juliana Echevarria-Lima, Denise de Abreu Pereira, Thais Silva de Oliveira, Otávio de Melo Espíndola, Marco Antonio Lima, Ana Cláudia Celestino Leite, Vanessa Sandim, Clarissa Rodrigues Nascimento, Dario E Kalume, Russolina B Zingali
Human T-cell lymphotropic virus type-1 (HTLV-1) is the etiological agent of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). The endothelial breakdown and migration of leukocytes, including monocytes, to the spinal cord are involved in HAM/TSP development. Monocytes from HTLV-1-infected individuals exhibit important functional differences when compared to cells from uninfected donors. Using proteomic shot gun strategy, performed by nanoACQUITY-UPLC system, we analyzed monocytes isolated from peripheral blood of asymptomatic carriers (AC), HAM/TSP and uninfected individuals...
September 25, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30237687/a-survey-on-human-t-cell-lymphotropic-virus-type-1-htlv-1-and-xenotropic-murine-leukemia-virus-related-virus-xmrv-coinfection-in-tehran-iran
#10
Mohsen Keshavarz, Mohammad Hadi Karbalaie Niya, Fahimeh Safarnezhad Tameshkel, Amir Sasan Mozaffari Nejad, Seyed Hamidreza Monavari, Hossein Keyvani
Background: Xenotropic murine leukemia virus-related virus (XMRV) is a gamma retrovirus, which has been detected in patients with prostate cancer, chronic fatigue syndrome, and general population with a number of acquired infections such as infection with human T-cell lymphotropic virus (HTLV) and human immunodeficiency virus (HIV). The aim of this study was to determine the HTLV-1 and XMRV coinfection for the first time in Iranian patients who were admitted to the Tehran hospitals. Materials and Methods: Two hundred and ninety one patients suspected with HTLV-1 were referred to the hospitals affiliated to the Iran University of Medical Sciences, Tehran, Iran from April 2012 to October 2016...
July 2018: Journal of Pharmacy & Bioallied Sciences
https://www.readbyqxmd.com/read/30232131/performance-of-commercially-available-serological-screening-tests-for-human-t-cell-lymphotropic-virus-infection-in-brazil
#11
Vanessa da Silva Brito, Fred Luciano Neves Santos, Noilson Lazaro Sousa Gonçalves, Thessika Hialla Araujo, Davi Silva Vale Nascimento, Felicidade Mota Pereira, Ney Cristian Amaral Boa-Sorte, Maria Fernanda Rios Grassi, Adele Caterino-de-Araujo, Bernardo Galvão-Castro
Serological screening for HTLV-1 is usually performed using enzyme-linked immunosorbent assay, particle agglutination or chemiluminescence assay kits. Due to antigen matrix improvement entailing the use of new HTLV-antigens and changes in the format of HTLV screening tests, as well as newly introduced CLIAs, a systematic evaluation of the accuracy of currently available commercial tests is warranted. We aimed to assess the performance of commercially available screening tests for HTLV diagnosis. A diagnostic accuracy study was conducted on a panel of 397 plasma samples: 200 HTLV-negative, 170 HTLV-positive and 27 indeterminate under Western blotting analysis...
September 19, 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/30229663/tax-mrna-carrying-exosomes-from-htlv-1-infected-cells-can-induce-ifn-%C3%AE-production-in-vitro
#12
Katia Kaori Otaguiri, Daiane Fernanda Dos Santos, Svetoslav Nanev Slavov, Lívia Depieri, Patrícia Viana Bonini Palma, Flávio Vieira Meirelles, Dimas Tadeu Covas, Juliano Coelho Da Silveira, Simone Kashima
BACKGROUND: Human T-cell lymphotropic virus type 1 (HTLV-1) is the etiological agent of HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T-cell leukemia/lymphoma (ATLL). The development of HAM/TSP, a chronic neuroinflammatory disease, is correlated to complex interaction between the host immune response and the infecting virus. Tax expression plays important role in HAM/TSP pathogenesis by activating various cellular genes, including the cytokines IFN-γ and TNF-α...
September 19, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/30181035/human-t-lymphotropic-virus-1-associated-myelopathy-tropical-spastic-paraparesis-is-associated-with-sexual-dysfunction-in-infected-women-of-reproductive-age
#13
Adenilda Lima Lopes Martins, Maria Fernanda Rios Grassi, Alisson de Aquino Firmino, Jean Paulo Lacerda Araujo, Taiane Silva Paixao, Bernardo Galvão-Castro, Ney Boa-Sorte
INTRODUCTION: Human T-lymphotropic virus (HTLV)-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurological disorder that mostly affects women. This disease is characterized by a progressive loss of motor function and disruptions in sensory function in the lower limbs. HTLV-1 is also associated with isolated neurologic dysfunctions, overactive bladder, and erectile dysfunction. The occurrence of sexual dysfunction in HTLV-1-infected women remain unclear. AIM: To investigate associations between HTLV-1 infection and sexual dysfunction in both asymptomatic infected women and those diagnosed with HAM/TSP compared with uninfected women...
September 1, 2018: Sexual Medicine
https://www.readbyqxmd.com/read/30159298/absence-of-flt3-mutations-in-iranian-adult-t-cell-leukemia-lymphoma-patients
#14
Hossein Ayatollahi, Mohammadhadi Sadeghian, Mohammadmahdi Kooshyar, Abass Shirdel, Hossein Rahimi, Amirhossein Jafarian, Saeide Ghazaei, Narges Soltani, Fatemeh Shams, Neda Motamedi Rad, Sepideh Shakeri
Background: Adult T cell leukemia lymphoma (ATLL) is a rare disease, significantly linked to the infection by the human T-cell lymphotropic virus 1(HTLV-1). ATLL is typically preceded by decades of clinical latency during which infected cells accumulate selectable traits leading to a malignant transformation. Amongst all the HTLV-1 infected carriers only about 3-5% will develop ATLL. Despite the intensive attempt to improve the overall survival, ATLL remains one of worse prognosis among the hematologic malignancies...
2018: Medical Journal of the Islamic Republic of Iran
https://www.readbyqxmd.com/read/30148843/spinal-cord-hypometabolism-associated-with-infection-by-human-t-cell-lymphotropic-virus-type-1-htlv-1
#15
Luiz C F Romanelli, Débora M Miranda, Anna B F Carneiro-Proietti, Marcelo Mamede, Herika M M Vasconcelos, Marina L Martins, Anísia S D Ferreira, Daniela V F Rosa, Jonas J Paula, Marco A Romano-Silva, Rodrigo Nicolato
BACKGROUND: HTLV-1 infection is endemic in Brazil. About 1 to 2% of the Brazilian population is estimated to be infected, but most infected HTLV-1 individuals do not know about their own infection, which favors the continuity of sexual and vertical virus transmission. In addition, HTLV-1 associated central nervous system diseases and their pathophysiologic mechanisms are not fully understood. This study aimed to evaluate the correlation of spinal cord metabolism, viral and inflammatory profiles with features of neurological presentation in HTLV-1 infected individuals...
August 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/30138509/human-t-lymphotropic-virus-1-associated-with-adult-t-cell-leukemia-lymphoma
#16
Travis James, David Fivenson, Jenny Cotton
Adult T-cell leukemia/lymphoma (ATLL) is an uncommon neoplasm of mature T lymphocytes associated with infection by human T-lymphotropic virus 1 (HTLV-1), which is increasing in incidence in areas of the United States with large immigrant populations. Human T-lymphotrophic virus 1 infection is asymptomatic in most patients and has been associated with ATLL as well as tropical spastic paraparesis. Because there is considerable histologic overlap with other cutaneous T-cell lymphomas, high suspicion and clinical features must be present to make the diagnosis of ATLL...
July 2018: Cutis; Cutaneous Medicine for the Practitioner
https://www.readbyqxmd.com/read/30135211/peptide-mhc-pmhc-binding-to-a-human-antiviral-t-cell-receptor-induces-long-range-allosteric-communication-between-pmhc-and-cd3-binding-sites
#17
Sneha Rangarajan, Yanan He, Yihong Chen, Melissa C Kerzic, Buyong Ma, Ragul Gowthaman, Brian G Pierce, Ruth Nussinov, Roy A Mariuzza, John Orban
T cells generate adaptive immune responses mediated by the T cell receptor (TCR)-CD3 complex comprising an αβ TCR heterodimer non-covalently associated with three CD3 dimers. In early T cell activation, αβ TCR engagement by peptide-major histocompatibility complex (pMHC) is first communicated to the CD3 signaling apparatus of the TCR-CD3 complex, but the underlying mechanism is incompletely understood. It is possible that pMHC binding induces allosteric changes in TCR conformation or dynamics that are then relayed to CD3...
August 22, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/30125933/cobomarsen-an-oligonucleotide-inhibitor-of-mir-155-co-ordinately-regulates-multiple-survival-pathways-to-reduce-cellular-proliferation-and-survival-in-cutaneous-t-cell-lymphoma
#18
Anita G Seto, Xuan Beatty, Joshua M Lynch, Melanie Hermreck, Michael Tetzlaff, Madeleine Duvic, Aimee L Jackson
miR-155, a microRNA associated with poor prognosis in lymphoma and leukaemia, has been implicated in the progression of mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma (CTCL). In this study, we developed and tested cobomarsen (MRG-106), a locked nucleic acid-modified oligonucleotide inhibitor of miR-155. In MF and human lymphotropic virus type 1 (HTLV-1+) CTCL cell lines in vitro, inhibition of miR-155 with cobomarsen de-repressed direct miR-155 targets, decreased expression of multiple gene pathways associated with cell survival, reduced survival signalling, decreased cell proliferation and activated apoptosis...
August 20, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/30091222/bullous-cd4-cd8-adult-t-cell-leukemia-lymphoma-a-rare-diagnostically-challenging-cutaneous-variant
#19
Preetha Kamath, Jennifer Abrahams, Jeong Hee Cho-Vega
No abstract text is available yet for this article.
August 9, 2018: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/30090093/proposal-of-classification-criteria-for-htlv-1-associated-myelopathy-tropical-spastic-paraparesis-disease-activity
#20
Tomoo Sato, Naoko Yagishita, Keiko Tamaki, Eisuke Inoue, Daisuke Hasegawa, Misako Nagasaka, Hiroko Suzuki, Natsumi Araya, Ariella Coler-Reilly, Yasuhiro Hasegawa, Yoshio Tsuboi, Ayako Takata, Yoshihisa Yamano
Human T-lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a rare chronic neuroinflammatory disease. While the disease usually progresses slowly without remission, there is a subgroup of patients with rapid progression and another subgroup with very slow progression. However, there have been no reports to date that have successfully determined the criteria to differentiate these subgroups. Therefore, we initially conducted a statistical modeling analysis to explore representative patterns of disease progression using data from our nationwide HAM/TSP patient registration system ("HAM-net")...
2018: Frontiers in Microbiology
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