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Mir-143 and cardiomyocytes

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https://www.readbyqxmd.com/read/26423156/carmen-a-human-super-enhancer-associated-long-noncoding-rna-controlling-cardiac-specification-differentiation-and-homeostasis
#1
Samir Ounzain, Rudi Micheletti, Carme Arnan, Isabelle Plaisance, Dario Cecchi, Blanche Schroen, Ferran Reverter, Michael Alexanian, Christine Gonzales, Shi Yan Ng, Giovanni Bussotti, Iole Pezzuto, Cedric Notredame, Stephane Heymans, Roderic Guigó, Rory Johnson, Thierry Pedrazzini
Long noncoding RNAs (lncRNAs) are emerging as important regulators of developmental pathways. However, their roles in human cardiac precursor cell (CPC) remain unexplored. To characterize the long noncoding transcriptome during human CPC cardiac differentiation, we profiled the lncRNA transcriptome in CPCs isolated from the human fetal heart and identified 570 lncRNAs that were modulated during cardiac differentiation. Many of these were associated with active cardiac enhancer and super enhancers (SE) with their expression being correlated with proximal cardiac genes...
December 2015: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/26286600/identification-of-apoptosis-related-micrornas-and-their-target-genes-in-myocardial-infarction-post-transplantation-with-skeletal-myoblasts
#2
Qi Liu, Guo Qing Du, Zhi Tao Zhu, ChunYang Zhang, Xiao Wei Sun, Jing Jin Liu, Xia Li, Yong Shun Wang, Wen Juan Du
BACKGROUND: Skeletal myoblasts (SkMs) has provided a promising treatment for myocardial infarction (MI). Functioning as posttranscriptional regulators, microRNAs (miRNAs) play important roles in cardiac repairment and stem cell regulation. However, the correlation between miRNAs and their targeted genes in SkM cell therapy for MI was not fully understood. METHODS: We explored the cardioprotection by SkMs in infracted rats and determined cardiac functions at 4 weeks...
2015: Journal of Translational Medicine
https://www.readbyqxmd.com/read/25131238/regulation-of-lovastatin-on-a-key-inflammation-related-microrna-in-myocardial-cells
#3
Weizao Guo, Huichen Liu, Lin Li, Man Yang, Aihua Du
BACKGROUND: Advances in the understanding of cardiovascular pathogenesis have highlighted that inflammation plays a central role in atherosclerotic coronary heart disease. Therefore, exploring pharmacologically based anti-inflammatory treatments to be used in cardiovascular therapeutics is worthwhile to promote the discovery of novel ways of treating cardiovascular disorders. METHODS: The myocardial cell line H9c2(2-1) was exposed to lipopolysaccharide (LPS) in culture and resulted in a cellular pro-inflammation status...
2014: Chinese Medical Journal
https://www.readbyqxmd.com/read/24161319/circulating-mir-29a-among-other-up-regulated-micrornas-is-the-only-biomarker-for-both-hypertrophy-and-fibrosis-in-patients-with-hypertrophic-cardiomyopathy
#4
Roberta Roncarati, Chiara Viviani Anselmi, Maria Angela Losi, Laura Papa, Elena Cavarretta, Paula Da Costa Martins, Carla Contaldi, Gloria Saccani Jotti, Anna Franzone, Laura Galastri, Michael V G Latronico, Massimo Imbriaco, Giovanni Esposito, Leon De Windt, Sandro Betocchi, Gianluigi Condorelli
OBJECTIVES: The purpose of this paper was to determine whether microRNAs (miRNAs) involved in myocardial remodeling were differentially expressed in the blood of hypertrophic cardiomyopathy (HCM) patients, and whether circulating miRNAs correlated with the degree of left ventricular hypertrophy and fibrosis. BACKGROUND: miRNAs-small, noncoding ribonucleic acids (RNAs) that regulate gene expression by inhibiting RNA translation-modulate cellular function. Myocardial miRNAs modulate processes such as cardiomyocyte (CM) hypertrophy, excitation-contraction coupling, and apoptosis; non-CM-specific miRNAs regulate myocardial vascularization and fibrosis...
March 11, 2014: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/23812417/activin-a-impairs-insulin-action-in-cardiomyocytes-via-up-regulation-of-mir-143
#5
Marcel Blumensatt, Sabrina Greulich, Daniella Herzfeld de Wiza, Heidi Mueller, Bujar Maxhera, Martijn J Rabelink, Rob C Hoeben, Payam Akhyari, Hadi Al-Hasani, Johannes B Ruige, D Margriet Ouwens
AIMS: Enhanced activin A release from epicardial adipose tissue (EAT) has been linked to the development of cardiac dysfunction in type 2 diabetes (T2D). This study examined whether the inhibition of insulin action induced by epicardial adipokines in cardiomyocytes can be ascribed to alterations in miRNA expression. METHODS AND RESULTS: Expression levels of miRNAs were assessed by real-time PCR in primary adult rat cardiomyocytes (ARC) exposed to conditioned media generated from EAT biopsies (CM-EAT) from patients with and without T2D...
November 1, 2013: Cardiovascular Research
https://www.readbyqxmd.com/read/22135162/role-of-micrornas-in-stem-progenitor-cells-and-cardiovascular-repair
#6
REVIEW
Philipp Jakob, Ulf Landmesser
MicroRNAs (miRNAs), small non-coding RNAs, play a critical role in differentiation and self-renewal of pluripotent stem cells, as well as in differentiation of cardiovascular lineage cells. Several miRNAs have been demonstrated to repress stemness factors such as Oct4, Nanog, Sox2 and Klf4 in embryonic stem cells, thereby promoting embryonic stem cell differentiation. Furthermore, targeting of different miRNAs promotes reprogramming towards induced pluripotent stem cells. MicroRNAs are critical for vascular smooth muscle cell differentiation and phenotype regulation, and miR-143 and miR-145 play a particularly important role in this respect...
March 15, 2012: Cardiovascular Research
https://www.readbyqxmd.com/read/22110643/distinct-roles-of-microrna-1-and-499-in-ventricular-specification-and-functional-maturation-of-human-embryonic-stem-cell-derived-cardiomyocytes
#7
Ji-Dong Fu, Stephanie N Rushing, Deborah K Lieu, Camie W Chan, Chi-Wing Kong, Lin Geng, Kitchener D Wilson, Nipavan Chiamvimonvat, Kenneth R Boheler, Joseph C Wu, Gordon Keller, Roger J Hajjar, Ronald A Li
BACKGROUND: MicroRNAs (miRs) negatively regulate transcription and are important determinants of normal heart development and heart failure pathogenesis. Despite the significant knowledge gained in mouse studies, their functional roles in human (h) heart remain elusive. METHODS AND RESULTS: We hypothesized that miRs that figure prominently in cardiac differentiation are differentially expressed in differentiating, developing, and terminally mature human cardiomyocytes (CMs)...
2011: PloS One
https://www.readbyqxmd.com/read/20460367/the-mir-143-adducin3-pathway-is-essential-for-cardiac-chamber-morphogenesis
#8
Dekker C Deacon, Kathleen R Nevis, Timothy J Cashman, Yong Zhou, Long Zhao, Daniel Washko, Burcu Guner-Ataman, C Geoffrey Burns, Caroline E Burns
Discovering the genetic and cellular mechanisms that drive cardiac morphogenesis remains a fundamental goal, as three-dimensional architecture greatly impacts functional capacity. During development, accurately contoured chambers balloon from a primitive tube in a process characterized by regional changes in myocardial cell size and shape. How these localized changes are achieved remains elusive. Here, we show in zebrafish that microRNA-143 (miR-143) is required for chamber morphogenesis through direct repression of adducin3 (add3), which encodes an F-actin capping protein...
June 2010: Development
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