Jiamin Li, Chaoqian Xu, Yining Liu, Yuanshi Li, Sijia Du, Ruijie Zhang, Yuehang Sun, Ronghao Zhang, Ying Wang, Hongru Xue, Sha Ni, Mavlikhanova Asiya, Genlong Xue, Yanyao Li, Ling Shi, Desheng Li, Zhenwei Pan, Yong Zhang, Zhiguo Wang, Benzhi Cai, Ning Wang, Baofeng Yang
Ventricular arrhythmia is the most common cause of sudden cardiac death in patients with myocardial infarction (MI). Fibroblast growth factor 21 (FGF21) has been shown to play an important role in cardiovascular and metabolic diseases. However, the effects of FGF21 on ventricular arrhythmias following MI have not been addressed yet. The present study was conducted to investigate the pharmacological action of FGF21 on ventricular arrhythmias after MI. Adult male mice were administrated with or without recombinant human basic FGF21 (rhbFGF21), and the susceptibility to arrhythmias was assessed by programmed electrical stimulation and optical mapping techniques...
January 4, 2020: Basic Research in Cardiology