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https://www.readbyqxmd.com/read/30334464/cancer-related-distress-in-unselected-women-with-newly-diagnosed-breast-or-ovarian-cancer-undergoing-brca1-2-testing-without-pretest-genetic-counseling
#1
Hildegunn Høberg-Vetti, Geir Egil Eide, Elen Siglen, Wenche Listøl, Marianne Tveit Haavind, Nicoline Hoogerbrugge, Cathrine Bjorvatn
BACKGROUND: Genetic testing is increasing in patients newly diagnosed with cancer. This study investigated the levels, course and predictors of cancer-related distress, defined as intrusion and avoidance, in women undergoing BRCA1/2 testing without pretest genetic counseling shortly after a diagnosis of breast or ovarian cancer. MATERIAL AND METHODS: Unselected for family history or age, 259 women with breast cancer and 50 women with ovarian cancer, underwent BRCA1/2 testing shortly after diagnosis...
October 18, 2018: Acta Oncologica
https://www.readbyqxmd.com/read/30327857/-ki67-biological-intertumor-variance-versus-variance-of-assay
#2
REVIEW
H Kreipe
Since its first description at the Institute of Pathology in Kiel more than 34 years ago, the immunohistochemical proliferation marker Ki67 has been shown to be of prognostic significance in a huge number of retrospective and even some prospective trials on malignant tumours of various tissue derivation. Lack of standardization in the evaluation provides potential sources of variance in assessment. Tumour area to be assessed, minimum number of cells to be analyzed, tedious counting cell by cell or semiquantitative eyeballing, choice of immunohistochemical techniques represent nonstandardized issues that potentially lead to considerable assay heterogeneity...
October 16, 2018: Der Pathologe
https://www.readbyqxmd.com/read/30327540/trends-over-42-years-in-the-adult-medical-genetics-clinic-at-the-university-of-washington
#3
Elizabeth A Gay, Peter H Byers, Robin L Bennett, Thomas D Bird, Fuki M Hisama
PURPOSE: We analyzed the patients served by the University of Washington Adult Genetic Medicine Clinic (UWAGMC) over a 42-year period to determine how clinical services have changed and to evaluate the contributing factors. METHODS: We conducted a retrospective survey of patients seen by UWAGMC that included patients seen from 1975 to 2016. Variables considered included referral indication, disease status, and clinic visit date. Indications for referral were then binned into clinical categories for descriptive analysis...
October 16, 2018: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/30322793/a-randomized-controlled-trial-of-brief-mindfulness-meditation-for-women-undergoing-stereotactic-breast-biopsy
#4
Chelsea G Ratcliff, Sarah Prinsloo, Alejandro Chaoul, Stephanie G Zepeda, Rex Cannon, Amy Spelman, Wei T Yang, Lorenzo Cohen
PURPOSE: Stereotactic breast biopsy (SBB) is a common, anxiety-producing procedure. Nonpharmacologic methods to manage acute anxiety are needed. METHODS: In this single-blind trial, women were recruited before SBB and randomized in a 2:2:1 ratio to a single session of guided mindfulness-based meditation (GM; n = 30), focused breathing (FB; n = 30), or standard care (SC; n = 16). Anxiety and pain were assessed at baseline after a 10-min prebiopsy group-specific activity (GM, FB, or SC), every 4 min during SBB, and after biopsy...
October 11, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/30320707/direct-to-consumer-genetic-testing-for-breast-cancer-risk
#5
E Kate Reed, Emily A Edelman
Increasingly, individuals are interested in genetic testing to find out if they are at increased risk for breast cancer and other diseases. Through direct-to-consumer genetic testing, people can receive information about many different traits, including some risk information about hereditary breast and ovarian cancer syndrome. With more people getting this information outside of the medical setting, clinicians should be aware of the benefits and limitations of such testing.
October 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/30306449/a-workplace-based-intervention-to-improve-awareness-knowledge-and-utilization-of-breast-cervical-and-colorectal-cancer-screenings-among-latino-service-and-manual-labor-employees-in-utah
#6
Echo L Warner, Laura Martel, Judy Y Ou, Gina E Nam, Sara Carbajal-Salisbury, Virginia Fuentes, Anne C Kirchhoff, Deanna Kepka
In the United States, Latinos are more likely to be uninsured and diagnosed with later stage cancer than non-Hispanic whites. Promotoras (lay health educators) help improve cancer knowledge and facilitate access to cancer screenings. We tested a promotora led workplace-based intervention to improve knowledge of and adherence to breast, cervical, and colorectal cancer screening among Latino employees in service or manual labor jobs. Latinos 18 and older from Salt Lake County, Utah were enrolled from January 2015 to February 2016...
October 10, 2018: Journal of Community Health
https://www.readbyqxmd.com/read/30300580/myc-interacts-with-the-g9a-histone-methyltransferase-to-drive-transcriptional-repression-and-tumorigenesis
#7
William B Tu, Yu-Jia Shiah, Corey Lourenco, Peter J Mullen, Dharmendra Dingar, Cornelia Redel, Aaliya Tamachi, Wail Ba-Alawi, Ahmed Aman, Rima Al-Awar, David W Cescon, Benjamin Haibe-Kains, Cheryl H Arrowsmith, Brian Raught, Paul C Boutros, Linda Z Penn
MYC is an oncogenic driver that regulates transcriptional activation and repression. Surprisingly, mechanisms by which MYC promotes malignant transformation remain unclear. We demonstrate that MYC interacts with the G9a H3K9-methyltransferase complex to control transcriptional repression. Inhibiting G9a hinders MYC chromatin binding at MYC-repressed genes and de-represses gene expression. By identifying the MYC box II region as essential for MYC-G9a interaction, a long-standing missing link between MYC transformation and gene repression is unveiled...
October 8, 2018: Cancer Cell
https://www.readbyqxmd.com/read/30297301/-i-just-want-to-be-able-to-make-a-choice-results-from-citizen-deliberations-about-mammography-screening-in-ontario-canada
#8
Julia Abelson, Laura Tripp, Jonathan Sussman
Despite Canada's long history with mammography screening, little is known about citizens' perspectives about mammography and how best to support women to make informed choices about screening. To address this gap, a series of four citizen deliberation events were held in 2015-16 in Ontario, a Canadian province with an organized population-based breast screening program in place since 1990. Forty-nine individuals participated in four citizen panels, each comprising an information session highlighting the evidence about mammography, and large- and small-group deliberations about approaches to support informed decision making for screening...
September 28, 2018: Health Policy
https://www.readbyqxmd.com/read/30294348/cancer-trends-in-a-province-of-southwest-of-iran-2003-2016
#9
Ali Ahmadi, Fatemeh Salehi, Zenab Ahmadimirghaed
Background: Awareness of the trends of cancer incidence in each geographic region is an important. The aim of present study was to determine the incidence trends of cancer in Chaharmahal and Bakhtiari (Ch and B) province in Southwest of Iran. Materials and Methods: In this secondary data analysis, retrospective existing data were used from cancer registry reports in Ch and B in Southwest of Iran in 2003-2016. Data on epidemiologic trend were analyzed using Joinpoint software package and annual percentage change (APC) with 95% confidence interval (95% CI) was computed...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/30293241/does-intra-operative-margin-assessment-improve-margin-status-and-re-excision-rates-a-population-based-analysis-of-outcomes-in-breast-conserving-surgery-for-ductal-carcinoma-in-situ
#10
Alison Laws, Mantaj S Brar, Antoine Bouchard-Fortier, Brad Leong, May Lynn Quan
BACKGROUND AND OBJECTIVES: Using a 2 mm margin criteria, we evaluated the effect of intra-operative margin assessment on margin status and re-excisions following breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS). METHODS: We identified patients undergoing BCS for DCIS from a prospective, population-based database. Multivariable logistic regression was used to determine the effect of specimen mammography, ultrasound and macroscopic assessment by a pathologist on margins and re-excision rates...
October 7, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30292501/a-questionnaire-study-of-radiography-educator-opinions-about-patient-lead-shielding-during-digital-projection-radiography
#11
C Shanley, K Matthews
BACKGROUND: In projection radiography, lead rubber shielding has long been used to protect the gonads both within and outside the collimated field. However, the relative radio-sensitivity of the gonads is considered lower than previously, and doses from digital projection radiography are reported as being lower than in previous eras. These factors, along with technical difficulties encountered in placing lead shielding effectively, lead to varied opinions on the efficacy of such shielding in peer reviewed literature...
November 2018: Radiography
https://www.readbyqxmd.com/read/30291050/predictors-of-complications-following-breast-reduction-surgery-a-national-surgical-quality-improvement-program-study-of-16-812-cases
#12
Andrew M Simpson, Daniel P Donato, Alvin C Kwok, Jayant P Agarwal
BACKGROUND: Breast reduction is one of the most common procedures performed by plastic surgeons. Despite good outcomes and high patient satisfaction, there are little national data on the predictors that lead to complications in this patient population. We accessed a national outcomes database to examine these factors. METHODS: This is a retrospective study examining the National Surgical Quality Improvement Program database from 2006 to 2015. Patients who underwent primary breast reduction were identified...
September 20, 2018: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/30288565/complication-of-ruptured-poly-implant-proth%C3%A3-se-%C3%A2-breast-implants-combined-with-aquafilling-%C3%A2-gel-injection-a-case-report-and-literature-review
#13
Jaewoo Kim, Hak Chang, Ji-Ung Park
INTRODUCTION: We describe the first case of a patient who received AQUAfilling® gel (Biomedica, Prague, Czech Republic) after augmentation with Poly Implant Prothèse® (PIP) breast implants and later developed breast deformity with bilateral implant rupture. CASE REPORT: A 49-year-old Korean female patient who received breast augmentation with PIP implants 18 years ago and subsequent insertion of AQUAfilling® gel 1 year ago visited our center with a chief complaint of pain and decreased implant sizes in both breasts...
October 4, 2018: Aesthetic Plastic Surgery
https://www.readbyqxmd.com/read/30288493/evaluation-of-breast-cancer-bc-awareness-among-female-university-students-in-zarqa-university-jordan
#14
Ashraf Kan'an
Objective: The purposes of this study were to assess the level of Breast Cancer (BC) awareness of Jordanian female university students, measure their attitudes toward BC treatment, and compare the level of awareness and attitudes of students in the science and humanities faculties. Materials and Methods: The current study was cross-sectional and conducted among female students in Zarqa University in Jordan. Stratified random sampling and simple random sampling were employed to select the colleges and the students, respectively...
October 2018: European Journal of Breast Health
https://www.readbyqxmd.com/read/30287992/unusual-breast-neoplasm-with-diagnostic-and-management-challenges
#15
Chanchal Rana, Pooja Ramakant, Suresh Babu, Kulranjan Singh, Anand Mishra, Sasi Mouli
With the growing awareness and availability of proper screening methods, detection of breast lump is increasing globally and is now a very sensitive issue for females. The treatment of these lumps ranges from lumpectomy to wide local excision to mastectomy; hence, a proper diagnosis is very important to prevent under- or overtreatment in patients. Breast lesions are the heterogeneous diseases encompassing several distinct entities with remarkably different characteristics. While the more common forms of breast cancers are well recognized and understood better, there are many important unusual lesions and malignancies that are less known and less appreciated and can be challenging to diagnose...
September 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30287991/a-survey-on-breast-cancer-awareness-among-medical-paramedical-and-general-population-in-north-india-using-self-designed-questionnaire-a-prospective-study
#16
Pooja Ramakant, Kul Ranjan Singh, Sapna Jaiswal, Sudhir Singh, Priya Ranjan, Chanchal Rana, Vinod Jain, Anand K Mishra
Breast cancer (BC) has become the most common cancer in urban women. Unfortunately, most women are not aware of BC symptoms/signs, prevention, and management. In resource-limited countries like India where we do not have structured screening/awareness programs, a majority of women present with locally advanced BC. The aim of our study is to identify the present status of awareness about BC prevention, early detection, symptoms, and management in urban and rural Indian women (medical, paramedical, and nonmedical) and to assess whether education and socioeconomic strata have any role in better awareness about BC or not...
September 2018: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/30287178/the-impact-of-breast-density-reporting-laws-on-women-s-awareness-of-density-associated-risks-and-conversations-regarding-supplemental-screening-with-providers
#17
Nancy M Cappello, Dorinda Richetelli, Christoph I Lee
OBJECTIVE: We conducted a national survey to understand the impact of state-level density reporting laws on women's level of density risk awareness and their engagement in conversations with providers regarding supplemental screening. METHODS: In all, 1,500 US women aged 40 to 74 years who obtained a mammogram within 2 years were surveyed in February 2018. The sampling design yielded 300 respondents in each of five groups categorized based on density reporting law features...
September 17, 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/30285074/between-race-differences-in-processes-predicting-physician-communication-for-african-american-and-european-american-recipients-of-breast-density-notifications
#18
Mark Manning, Terrance L Albrecht, Louis Penner, Kristen Purrington
Background: Breast density notification laws mandate reporting of dense breast to applicable women. The same psychological and systemic barriers that yield between-race differences in mammography use will probably yield between-race differences in women's psychological and behavioral responses to breast density notifications. Purpose: We used the theory of planned behavior as a framework to examine between-race differences in the likelihood of following-up with physicians after receiving breast density notifications and to examine differences in African American and Caucasian American women's behavioral decision-making processes...
October 3, 2018: Annals of Behavioral Medicine: a Publication of the Society of Behavioral Medicine
https://www.readbyqxmd.com/read/30282419/mechanical-irritation-by-protruding-bone-a-possible-cause-of-breast-implant-rupture
#19
Matthias Michael Aitzetmüller, David Johannes Haslhofer, Raphael Wenny, Manfred Schmidt, Dominik Duscher, Georg Michael Huemer
Although breast implants have been in clinical use for almost 6 decades and have undergone considerable development during this time, implant rupture is still a dreaded long-term complication. Some obvious external factors, such as trauma, can lead to implant rupture, but many studies have reported a high rate of "spontaneous" implant rupture. Herein, we present two cases with the aim of raising awareness of a new possible cause of "spontaneous" implant rupture: mechanical irritation by bony protrusions...
September 2018: Archives of Plastic Surgery
https://www.readbyqxmd.com/read/30281704/clinical-stage-and-histological-type-of-the-most-common-carcinomas-diagnosed-in-young-adults-in-a-reference-cancer-hospital
#20
Marina Candido Visontai Cormedi, Edia Filomena Di Tullio Lopes, Simone Maistro, Rosimeire Aparecida Roela, Maria Aparecida Azevedo Koike Folgueira
OBJECTIVES: Cancer in young adults represents a great challenge, both biologically and socially, and understanding the unique characteristics of neoplasms in this age group is important to improving care. We aimed to evaluate the most common carcinomas and their characteristics, such as histological type and clinical stage, in young adults in the largest cancer hospital in Latin America. METHODS: The hospital registry was consulted for the period between 2008 and 2014...
September 21, 2018: Clinics
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