Dan Su, Zhong Chen, Xiaobin An, Junkai Yang, Jinan Yang, Xuqiao Wang, Yang Qu, Chen Gong, Yani Chai, Xiaoying Liu, Wei Cheng, Dongyang Wang, Yan Wu, Jing Ma, Xinyue Zhao, Qin Wang, Yun Xu, Haisheng Peng, Jing Ai
The complex etiologies and mechanisms of Alzheimer's disease (AD) underscore the importance for devising multitarget drugs to achieve effective therapy. MicroRNAs (miRNAs) are capable of concurrently regulating the expression of multiple proteins by selectively targeting disease- associated genes in a sequence-specific fashion. Nonetheless, as RNA-based drugs, their stability in the circulation and capacity of traversing the blood-brain barrier (BBB) is largely compromised, thereby limiting their potential clinical applications...
December 6, 2023: Journal of Controlled Release