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https://www.readbyqxmd.com/read/27922466/smartphone-based-electrocardiographic-and-cardiac-implantable-electronic-device-monitoring
#1
Suneet Mittal
The field of arrhythmia monitoring is changing rapidly. The rapid advent of technology in combination with marked improvements in cellular communication and an increased desire by patients to be actively engaged in their care has ushered in a new era of clinical care. Today, physicians need to think about their patients outside the traditional in-office setting. Two technologies that embody this changing landscape are smartphone-based electrocardiographic (ECG) monitors and remote monitoring of cardiac implantable electronic devices (CIEDs)...
January 2017: Cardiology in Review
https://www.readbyqxmd.com/read/27914999/dual-therapy-for-refractory-overactive-bladder-in-children-a-prospective-open-label-study
#2
Fannie Morin, Anne-Sophie Blais, Geneviève Nadeau, Katherine Moore, Lucie Genois, Stéphane Bolduc
PURPOSE: Mirabegron (β3-adrenoreceptor agonist) is a new molecule with a distinct mechanism of action from antimuscarinics. Combination therapy with solifenacin was recently studied in adult population. Our objective was to evaluate the efficacy and safety of mirabegron as add-on therapy, to treat urinary incontinence in children with idiopathic OAB, refractory/intolerant to antimuscarinics. MATERIALS AND METHODS: A prospective off-label study using add-on regimens of mirabegron was conducted with pediatric patients presenting no symptom improvement under intensive behavioural and medical therapies and/or significant side effects (S/E) on antimuscarinic dose escalation...
November 30, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27914360/white-blood-cell-count-and-new-onset-atrial-fibrillation-after-cardiac-surgery
#3
Kirolos A Jacob, Marc P Buijsrogge, Jos F Frencken, Maarten J Ten Berg, Willem J L Suyker, Diederik van Dijk, Jan M Dieleman
BACKGROUND: Postoperative new-onset atrial fibrillation (PNAF) is the most common complication following cardiac surgery. The inflammatory response, as a potential underlying mechanism, has been extensively studied. In small studies, the white blood cell count (WBC) has been shown to be the only consistent inflammatory marker associated with PNAF. This study aimed to determine the association between perioperative WBC response and PNAF in a larger study cohort. METHODS: Patients ≥18years, undergoing elective cardiac surgery with a preoperative sinus rhythm were included...
November 17, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27909507/symptom-rhythm-correlation-with-patient-owned-device-insights-into-practice-and-challenges
#4
REVIEW
Mohammed Shurrab Md M Sc, Anatoly Langer Md, Eugene Crystal Md, David Newman Md
Capturing symptom/rhythm correlation is crucial in patients who have rhythm-related symptoms. Evolving technology has led from 24 hour and 14 day Holter monitors to now external loop recorders to capture symptom/rhythm correlation. In patients with very infrequent and short-lived symptoms, the only recourse is an implantable recording device. Recently, patient activated recording devices have become available. These have the potential to significantly increase the duration for monitoring symptom/rhythm correlations...
June 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27909500/cardiac-rhythm-device-threshold-testing-via-pulse-oxymetry
#5
Vladimir Fridman Md, Cesare Saponieri Md, Nabil El-Sherif Md Facc Fhrs, Gioia Turitto Md Facc Fhrs
Threshold testing of cardiac rhythm devices is essential to monitoring the proper functioning of such devices (1). However, the currently method of applying multiple ECG leads to the patient is burdensome and time consuming (2). We are presenting a completely new way to perform cardiac rhythm device threshold testing using pulse oximetry. Twenty patients, with varying cardiac rhythm devices and pacing modes, were enrolled and had their atrial and ventricular thresholds tested. A comparison was made between simultaneous threshold determinations via the standard EGM based method and the new pulse oximetry based method...
April 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27909499/hyperacute-and-chronic-changes-in-cerebral-magnetic-resonance-images-after-pvac-nmarq-and-epicardial-thoracoscopic-surgical-ablation-for-paroxysmal-atrial-fibrillation
#6
Conn Sugihara Mbbs, Neil Barlow Mbbs, Emma Owens Mbbs, David Sallomi Mb ChB, Neil Sulke Md
Threshold testing of cardiac rhythm devices is essential to monitoring the proper functioning of such devices (1). However, the currently method of applying multiple ECG leads to the patient is burdensome and time consuming (2). We are presenting a completely new way to perform cardiac rhythm device threshold testing using pulse oximetry. Twenty patients, with varying cardiac rhythm devices and pacing modes, were enrolled and had their atrial and ventricular thresholds tested. A comparison was made between simultaneous threshold determinations via the standard EGM based method and the new pulse oximetry based method...
April 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27909484/lyme-arrhythmia-in-an-avid-golfer-a-diagnostic-challenge-and-a-therapeutic-dilemma
#7
Ujjwal Rastogi, Dr Nidhi Kumars
Lyme disease is a multisystem disorder affecting dermatologic, cardiac, nervous and musculoskeletal systems. Cardiac manifestations occur in about 5% of Lyme infections and stem from the involvement of the cardiac conduction system, resulting in varying degrees of sino-atrioventricular block. Occasionally, Lyme infection may also present with myopericarditis. Unlike isolated conduction node disease, myocardial involvement presents a great diagnostic and therapeutic dilemma for the physician. We report the case of a 68 year-old male cardiologist who presented with new onset exertional dyspnea and palpitations...
February 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27904509/a-new-diagnostic-tool-for-masked-hypertension-impaired-sleep-quality
#8
Fatma Erdem, Ugur Cakır, Osman Yıldırım, Aytekin Alcelik, Ibrahim Donmez, Taha Can Tuman, Sabri Onur Caglar, Alim Erdem, Mehmet Yazıcı
INTRODUCTION: The aim of this study was to evaluate the relationship between masked hypertension and impaired sleep quality. Additionally, we evaluated the diagnostic role and prevalence of poor sleep quality among patients with newly diagnosed masked hypertension. MATERIAL AND METHODS: A total of 112 individuals, 72 patients with newly diagnosed masked hypertension and 40 normotensive healthy volunteers, were included in this study. All patients underwent evaluation comprising 12-lead electrocardiography, transthoracic echocardiography, 24-hour Holter ECG, and basic laboratory tests...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27894269/prevalence-of-abdominal-aortic-aneurysms-and-its-relation-with-cardiovascular-risk-stratification-protocol-of-the-risk-of-cardiovascular-diseases-and-abdominal-aortic-aneurysm-in-varese-rocav-population-based-study
#9
F Gianfagna, G Veronesi, L Bertù, M Tozzi, A Tarallo, M M Ferrario, P Castelli
BACKGROUND: Recent meta-analyses suggested that screening program for abdominal aortic aneurysms (AAA) in 65-year old males is cost-effective at prevalence of about 1%. Since some events occur also in females and among the youngers, screening could be feasible among those at higher risk, such as smokers or individuals with a family history of AAA. The RoCAV (Risk of Cardiovascular diseases and abdominal aortic Aneurysms in Varese) Project is a population-based study aimed to evaluate AAA prevalence in Northern Italy in males over-65 years as well as among females and younger males, and to identify new markers for risk stratification by collecting a large set of CVD risk factors...
November 29, 2016: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/27893378/semi-supervised-stacked-label-consistent-autoencoder-for-reconstruction-and-analysis-of-biomedical-signals
#10
Angshul Majumdar, Anupriya Gogna, Rabab Ward
: An autoencoder based framework that simultaneously reconstruct and classify biomedical signals is proposed. Previous work has treated reconstruction and classification as separate problems. This is the first work that proposes a combined framework to address the issue in a holistic fashion. METHODS: For tele-monitoring purposes, reconstruction techniques of biomedical signals are largely based on compressed sensing (CS); these are 'designed' techniques where the reconstruction formulation is based on some 'assumption' regarding the signal...
November 22, 2016: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/27889554/familial-dilated-cardiomyopathy-a-multidisciplinary-entity-from-basic-screening-to-novel-circulating-biomarkers
#11
REVIEW
D de Gonzalo-Calvo, M Quezada, O Campuzano, A Perez-Serra, J Broncano, R Ayala, M Ramos, V Llorente-Cortes, S Blasco-Turrión, F J Morales, P Gonzalez, R Brugada, A Mangas, R Toro
Idiopathic dilated cardiomyopathy has become one of the most prevalent inherited cardiomyopathies over the past decades. Genetic screening of first-degree relatives has revealed that 30-50% of the cases have a familial origin. Similar to other heart diseases, familial dilated cardiomyopathy is characterized by a high genetic heterogeneity that complicates family studies. Cli'nical screening, 12-lead electrocardiogram and transthoracic echocardiogram are recommended for patients and first-degree family members...
November 8, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27889278/safety-and-efficacy-of-nepa-an-oral-fixed-combination-of-netupitant-and-palonosetron-in-older-patients
#12
Matti Aapro, Karin Jordan, Richard J Gralla, Giada Rizzi, Giorgia Rossi, Marco Palmas, Anna V Alyasova, Alla S Lisyanskaya, Snežana M Bošnjak, Paul J Hesketh
OBJECTIVES: Prevention of chemotherapy-induced nausea and vomiting is critical in older cancer patients. NEPA is an oral fixed combination of netupitant 300mg, a new NK1 receptor antagonist (RA), and palonosetron 0.5mg, a pharmacologically distinct 5-HT3 RA. This retrospective analysis evaluated the efficacy and safety of NEPA in older patients. METHODS: Patients aged ≥65 and ≥70years from one phase II and two phase III trials were considered. Chemotherapy-naive patients with malignant tumors were treated with anthracycline-cyclophosphamide (AC), non-AC-based moderately emetogenic chemotherapy (non-AC MEC), or highly emetogenic chemotherapy (HEC)...
November 23, 2016: Journal of Geriatric Oncology
https://www.readbyqxmd.com/read/27887644/copenhagen-comorbidity-in-hiv-infection-cocomo-study-a-study-protocol-for-a-longitudinal-non-interventional-assessment-of-non-aids-comorbidity-in-hiv-infection-in-denmark
#13
Andreas Ronit, Judith Haissman, Ditte Marie Kirkegaard-Klitbo, Thomas Skårup Kristensen, Anne-Mette Lebech, Thomas Benfield, Jan Gerstoft, Henrik Ullum, Lars Køber, Andreas Kjær, Klaus Kofoed, Jørgen Vestbo, Børge Nordestgaard, Jens Lundgren, Susanne Dam Nielsen
BACKGROUND: Modern combination antiretroviral therapy (cART) has improved survival for people living with HIV (PLWHIV). Non-AIDS comorbidities have replaced opportunistic infections as leading causes of mortality and morbidity, and are becoming a key health concern as this population continues to age. The aim of this study is to estimate the prevalence and incidence of non-AIDS comorbidity among PLWHIV in Denmark in the cART era and to determine risk factors contributing to the pathogenesis...
November 26, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27884663/early-impairment-in-left-ventricular-longitudinal-systolic-function-is-associated-with-an-increased-risk-of-incident-atrial-fibrillation-in-patients-with-type-2-diabetes
#14
Stefano Bonapace, Filippo Valbusa, Lorenzo Bertolini, Luciano Zenari, Guido Canali, Giulio Molon, Laura Lanzoni, Antonella Cecchetto, Andrea Rossi, Alessandro Mantovani, Giacomo Zoppini, Enrico Barbieri, Giovanni Targher
AIMS: It is known that type 2 diabetic patients are at high risk of atrial fibrillation (AF). However, the early echocardiographic determinants of AF vulnerability in this patient population remain poorly known. METHODS: We followed-up for 2years a sample of 180 consecutive outpatients with type 2 diabetes, who were free from AF and ischemic heart disease at baseline. All patients underwent a baseline echocardiographic-Doppler evaluation with tissue Doppler and 2-D strain analysis...
November 3, 2016: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/27884152/use-of-self-gated-radial-cardiovascular-magnetic-resonance-to-detect-and-classify-arrhythmias-atrial-fibrillation-and-premature-ventricular-contraction
#15
Eve Piekarski, Teodora Chitiboi, Rebecca Ramb, Li Feng, Leon Axel
BACKGROUND: Arrhythmia can significantly alter the image quality of cardiovascular magnetic resonance (CMR); automatic detection and sorting of the most frequent types of arrhythmias during the CMR acquisition could potentially improve image quality. New CMR techniques, such as non-Cartesian CMR, can allow self-gating: from cardiac motion-related signal changes, we can detect cardiac cycles without an electrocardiogram. We can further use this data to obtain a surrogate for RR intervals (valley intervals: VV)...
November 25, 2016: Journal of Cardiovascular Magnetic Resonance
https://www.readbyqxmd.com/read/27876299/-single-nucleotide-polymorphisms-in-genes-of-endothelin-1-and-receptor-a-associated-to-cardiovascular-in-essential-hypertension
#16
S R Tamiozzo, O C Lassen, J Herrera, P Igarzabal, S Tabares, A Sembaj
INTRODUCTION: The endothelin system, for its vasoconstrictor action, is related to the development of essential hypertension (HTAe). The polymorphism analysis of their genes represents a new approach to the study of this disease. We propose to analyze the interaction between stages of essential hypertension (HTAe) and risk factors with polymorphisms 138ex1 ins/del A gene endothelin-1 (ET-1) and H323H receptor gene A ET-1 (ETRA). PATIENTS AND METHODS: We included 300 patients of both sexes, unrelated, who consecutively attended the clinic hypertension medical service...
November 18, 2016: Hipertensión y Riesgo Vascular
https://www.readbyqxmd.com/read/27869101/a-stacked-contractive-denoising-auto-encoder-for-ecg-signal-denoising
#17
Peng Xiong, Hongrui Wang, Ming Liu, Feng Lin, Zengguang Hou, Xiuling Liu
As a primary diagnostic tool for cardiac diseases, electrocardiogram (ECG) signals are often contaminated by various kinds of noise, such as baseline wander, electrode contact noise and motion artifacts. In this paper, we propose a contractive denoising technique to improve the performance of current denoising auto-encoders (DAEs) for ECG signal denoising. Based on the Frobenius norm of the Jacobean matrix for the learned features with respect to the input, we develop a stacked contractive denoising auto-encoder (CDAE) to build a deep neural network (DNN) for noise reduction, which can significantly improve the expression of ECG signals through multi-level feature extraction...
November 21, 2016: Physiological Measurement
https://www.readbyqxmd.com/read/27868350/an-elderly-jervell-and-lange-nielsen-patient-heterozygous-compound-for-two-new-kcnq1-mutations
#18
Eliecer Coto, Francisco J García-Fernández, David Calvo, Ricardo Salgado-Aranda, Javier Martín-González, Belén Alonso, Sara Iglesias, Juan Gómez
We present the case of a 66-year-old female with early onset deafness and seizures, who was diagnosed with epilepsy at the age of 2 years. She received antiepileptic drugs and was free of syncope episodes for 32 years. After a syncope at the age of 34, the ECG was characteristic of long-QT syndrome and was treated with antiarrhythmic drugs. Sequencing of the KCNQ1 gene identified two novel KCNQ1 variants interpreted to be pathogenic, and the patient was finally diagnosed with Jervell and Lange-Nielsen syndrome...
November 21, 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/27863910/gabor-frames-for-classification-of-paroxysmal-and-persistent-atrial-fibrillation-episodes
#19
Nuria Ortigosa, Antonio Galbis, Carmen Fernández, Óscar Cano
In this study, we propose a new classification method for early differentiation of paroxysmal and persistent atrial fibrillation episodes, i.e. those which spontaneously or with external intervention will return to sinus rhythm within 7 days of onset from the ones where the arrhythmia is sustained for more than 7 days. Today, clinicians provide patients classification once the course of the arrhythmia has been disclosed. This classification problem is dealt with in this study. We study a sparse representation of surface electrocardiogram signals by means of Gabor frames and afterwards we apply a linear discriminant analysis...
November 15, 2016: Medical Engineering & Physics
https://www.readbyqxmd.com/read/27863351/abnormal-heart-rate-response-during-cardiopulmonary-exercise-testing-identifies-cardiac-dysfunction-in-symptomatic-patients-with-non-obstructive-coronary-artery-disease
#20
Sundeep Chaudhry, Naresh Kumar, Hushyar Behbahani, Akshay Bagai, Binoy K Singh, Nick Menasco, Gregory D Lewis, Laurence Sperling, Jonathan Myers
BACKGROUND: Symptomatic non-obstructive coronary artery disease is a growing clinical dilemma for which contemporary testing is proving to be of limited clinical utility. New methods are needed to identify cardiac dysfunction. METHODS AND RESULTS: This is a prospective observational cohort study conducted from December 2013 to August 2015 in two outpatient cardiology clinics (symptomatic cohort) and 24 outpatient practices throughout the US (healthy cohort) with centralized methodology and monitoring to compare heart-rate responses during cardiopulmonary exercise testing (CPET)...
November 14, 2016: International Journal of Cardiology
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