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https://www.readbyqxmd.com/read/30320400/the-possible-association-between-aqp9-in-the-intestinal-epithelium-and-acute-liver-injury%C3%A2-induced-intestinal-epithelium-damage
#1
Tianxin Xiang, Shanfei Ge, Jiangxiong Wen, Junfeng Xie, Lixia Yang, Xiaoping Wu, Na Cheng
The present study aimed to investigate the expression and function of aquaporin (AQP)9 in the intestinal tract of acute liver injury rat models. A total of 20 Sprague Dawley rats were randomly divided into four groups: Normal control (NC) group and acute liver injury groups (24, 48 and 72 h). Acute liver injury rat models were established using D‑amino galactose, and the serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (Tbil) and albumin were determined using an automatic biochemical analyzer...
October 10, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/30319275/knockdown-of-cldn6-inhibits-cell-proliferation-and-migration-via-pi3k-akt-mtor-signaling-pathway-in-endometrial-carcinoma-cell-line-hec-1-b
#2
Xia Cao, Guo-Zhao He
Backgroud: Dysregulation of claudin-6 (CLDN6) expression in cancers has been widely documented. However, no study has reported a complete mechanistic understanding of CLDN6 regulation and function in endometrial carcinoma (EC) progression. In the current study, we aimed to assess the expression and biological functions of CLDN6 in EC. Methods: Firstly, the expression level of CLDN6 in EC was measured based on The Cancer Genome Atlas (TCGA) database. Then, qRT-PCR and western blotting were implemented to detect the expression levels of CLDN6 in 82 pairs of EC tissues and corresponding non-tumor tissues, as well as EC cell line HEC-1B...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/30316711/cross-cultural-adaptation-of-the-cardiff-fertility-knowledge-scale-and-the-fertility-status-awareness-tool-for-the-french-canadian-population
#3
Claudine Blanchet, Véronique Babineau, Jacky Boivin, Stephanie-May Ruchat
OBJECTIVE: The Cardiff Fertility Knowledge Scale (CFKS) and the Fertility Status Awareness Tool (FertiSTAT) are validated tools allowing the evaluation of fertility knowledge and raising awareness about risk indicators for reduced fertility. Their use by health care professionals practicing in the field of reproductive health might optimize fertility of the Canadian population. However, there currently is no version of these questionnaires for the French-Canadian population. The objective of this study was to translate and culturally adapt the CFKS and FertiSTAT to the French-Canadian population...
October 10, 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/30315595/claudin-1-expression-decreases-with-increasing-pathological-grade-in-actinic-keratosis-and-may-be-a-marker-of-high-risk-actinic-keratosis
#4
J S Lee, H S Park, H S Yoon, S Cho
BACKGROUND: Actinic keratosis (AK) is a common sun-induced skin disorder that can progress to invasive squamous cell carcinoma. However, there is still no reliable method to predict high-risk AK. AIM: To identify markers that reflect the biological behaviour of AK and to understand the pathogenesis of AK. METHODS: In total, 52 patients with AK and 17 site-matched healthy controls (HCs) were enrolled. We evaluated solar elastosis and immunohistochemical features using antibodies to p53, vitamin D receptor (VDR), claudin-1 and Langerin (CD207)...
October 12, 2018: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/30312457/height-and-body-mass-index-as-modifiers-of-breast-cancer-risk-in-brca1-2-mutation-carriers-a-mendelian-randomization-study
#5
Frank Qian, Shengfeng Wang, Jonathan Mitchell, Lesley McGuffog, Daniel Barrowdale, Goska Leslie, Jan C Oosterwijk, Wendy K Chung, D Gareth Evans, Christoph Engel, Karin Kast, Cora M Aalfs, Muriel A Adank, Julian Adlard, Bjarni A Agnarsson, Kristiina Aittomäki, Elisa Alducci, Irene L Andrulis, Banu K Arun, Margreet G E M Ausems, Jacopo Azzollini, Emmanuelle Barouk-Simonet, Julian Barwell, Muriel Belotti, Javier Benitez, Andreas Berger, Ake Borg, Angela R Bradbury, Joan Brunet, Saundra S Buys, Trinidad Caldes, Maria A Caligo, Ian Campbell, Sandrine M Caputo, Jocelyne Chiquette, Kathleen B M Claes, J Margriet Collée, Fergus J Couch, Isabelle Coupier, Mary B Daly, Rosemarie Davidson, Orland Diez, Susan M Domchek, Alan Donaldson, Cecilia M Dorfling, Ros Eeles, Lidia Feliubadaló, Lenka Foretova, Jeffrey Fowler, Eitan Friedman, Debra Frost, Patricia A Ganz, Judy Garber, Vanesa Garcia-Barberan, Gord Glendon, Andrew K Godwin, Encarna B Gómez Garcia, Jacek Gronwald, Eric Hahnen, Ute Hamann, Alex Henderson, Carolyn B Hendricks, John L Hopper, Peter J Hulick, Evgeny N Imyanitov, Claudine Isaacs, Louise Izatt, Ángel Izquierdo, Anna Jakubowska, Katarzyna Kaczmarek, Eunyoung Kang, Beth Y Karlan, Carolien M Kets, Sung-Won Kim, Zisun Kim, Ava Kwong, Yael Laitman, Christine Lasset, Min Hyuk Lee, Jong Won Lee, Jihyoun Lee, Jenny Lester, Fabienne Lesueur, Jennifer T Loud, Jan Lubinski, Noura Mebirouk, Hanne E J Meijers-Heijboer, Alfons Meindl, Austin Miller, Marco Montagna, Thea M Mooij, Patrick J Morrison, Emmanuelle Mouret-Fourme, Katherine L Nathanson, Susan L Neuhausen, Heli Nevanlinna, Dieter Niederacher, Finn C Nielsen, Robert L Nussbaum, Kenneth Offit, Edith Olah, Kai-Ren Ong, Laura Ottini, Sue K Park, Paolo Peterlongo, Georg Pfeiler, Catherine M Phelan, Bruce Poppe, Nisha Pradhan, Paolo Radice, Susan J Ramus, Johanna Rantala, Mark Robson, Gustavo C Rodriguez, Rita K Schmutzler, Christina G Hutten Selkirk, Payal D Shah, Jacques Simard, Christian F Singer, Johanna Sokolowska, Dominique Stoppa-Lyonnet, Christian Sutter, Yen Yen Tan, R Manuel Teixeira, Soo H Teo, Mary Beth Terry, Thomassen Mads, Tischkowitz Marc, E Toland Amanda, M Tucker Katherine, Tung Nadine, Christi J van Asperen, Klaartje van Engelen, Elizabeth J van Rensburg, Shan Wang-Gohrke, Barbara Wappenschmidt, Jeffrey N Weitzel, Drakoulis Yannoukakos, Mark H Greene, Matti A Rookus, Douglas F Easton, Georgia Chenevix-Trench, Antonis C Antoniou, David E Goldgar, Olufunmilayo I Olopade, Timothy R Rebbeck, Dezheng Huo
Background: BRCA1/2 mutations confer high lifetime risk of breast cancer, although other factors may modify this risk. Whether height or body mass index (BMI) modifies breast cancer risk in BRCA1/2 mutation carriers remains unclear. Methods: We used Mendelian randomization approaches to evaluate the association of height and BMI on breast cancer risk, using data from the Consortium of Investigators of Modifiers of BRCA1/2 with 14 676 BRCA1 and 7912 BRCA2 mutation carriers, including 11 451 cases of breast cancer...
October 12, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/30310102/glutamate-alleviates-intestinal-injury-maintains-mtor-and-suppresses-tlr4-and-nod-signaling-pathways-in-weanling-pigs-challenged-with-lipopolysaccharide
#6
Qin Qin, Xiao Xu, Xiuying Wang, Huanting Wu, Huiling Zhu, Yongqing Hou, Bing Dai, Xiuting Liu, Yulan Liu
This experiment aimed to explore whether glutamate (Glu) had beneficial effects on intestinal injury caused by Escherichia coli LPS challenge via regulating mTOR, TLRs, as well as NODs signaling pathways. Twenty-four piglets were allotted to 4 treatments including: (1) control group; (2) LPS group; (3) LPS + 1.0% Glu group; (4) LPS + 2.0% Glu group. Supplementation with Glu increased jejunal villus height/crypt depth ratio, ileal activities of lactase, maltase and sucrase, and RNA/DNA ratio and protein abundance of claudin-1 in jejunum and ileum...
October 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30309728/mmp-9-upregulation-is-attenuated-by-the-monoclonal-tlr2-antagonist-t2-5-after-oxygen-glucose-deprivation-and-reoxygenation-in-rat-brain-microvascular-endothelial-cells
#7
Hongyan Zhu, Rongrong Dai, Hao Fu, Qiang Meng
BACKGROUND: Blood-brain barrier (BBB) disruption plays a key role in the pathophysiology of acute ischemic stroke. Matrix metalloproteinases-2/9 (MMP-2/9) have been shown to participate in the disruption of the BBB and hemorrhagic transformation after cerebral ischemia. Toll-like receptor 2 (TLR2) may also be correlated with endothelial cell injury during ischemia-reperfusion events. However, the correlation between MMP-2/9 and TLR2 on endothelial cells after ischemia has not yet been evaluated...
October 8, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/30309483/microrna-21-is-upregulated-during-intestinal-barrier-dysfunction-induced-by-ischemia-reperfusion
#8
Lin Zhang, Feng Zhang, Dai-Kun He, Xiao-Ming Fan, Jie Shen
This study aimed to investigate the expression of miRNA-21 during intestinal barrier dysfunction induced by intestinal ischemia reperfusion. Forty SPF SD rats were divided into 5 groups randomly. Intestinal ischemia-reperfusion injury (IRI) was induced by mesenteric artery occlusion for 1 h and reperfusion for 1 h, and the rats were sacrificed at 1, 3, 6 and 12 h after reperfusion. Fresh intestine tissues were immediately isolated for the measurement of transepithelial electrical resistance (TER). The levels of cytokines, ICAM-1, DAO, iFABP and MPO in serum were determined by ELISA...
October 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/30307765/n-acetylglucosaminyltransferase-i-as-a-novel-regulator-of-epithelial-mesenchymal-transition
#9
Guowei Zhang, Tomoya Isaji, Zhiwei Xu, Xu Lu, Tomohiko Fukuda, Jianguo Gu
N-Glycans are involved in numerous biologic processes, such as cell adhesion, migration, and invasion. To distinguish the functions of complex high-mannose types of N-glycans, we used the clustered, regularly interspaced, short palindromic repeats/Cas9 system to establish N-acetylglucosaminyltransferase (GnT)-I-knockout (KO) cells. Loss of GnT-I greatly induced cell-cell adhesion and decreased cell migration. In addition, the expression levels of epithelial-mesenchymal transition (EMT) markers such as α-SMA, vimentin, and N-cadherin were suppressed, whereas the expression of claudin-1 was promoted, suggesting a mesenchymal-epithelial transition-like phenotype, an opposite process to the EMT, was occurred in the KO cells...
October 11, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/30307745/enhanced-gastrointestinal-passive-paracellular-permeability-contributes-to-the-obesity-associated-hyperoxaluria
#10
Mohamed Bashir, Jon Meddings, Altayeb Alshaikh, Daniel Jung, Kim Le, Ruhul Amin, Sireesha Ratakonda, Sapna Sharma, Ignacio Granja, Mustafa Satti, John Asplin, Hatim Hassan
Most kidney stones (KS) are composed of calcium oxalate and small increases in urine oxalate enhance the stone risk. Obesity is a risk factor for KS and urinary oxalate excretion increases with increased body size. We previously established the obese ob/ob ( ob) mice as a model (3.3-fold higher urine oxalate) to define the pathogenesis of obesity-associated hyperoxaluria (OAH). The purpose of this study was to test the hypothesis that the obesity-associated enhanced intestinal paracellular permeability contributes to OAH by increasing passive paracellular intestinal oxalate absorption...
October 11, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/30305135/mechanism-of-pir-dq590027-mir17hg-regulating-the-permeability-of-glioma-conditioned-normal-bbb
#11
Xue Leng, Jun Ma, Yunhui Liu, Shuyuan Shen, Hai Yu, Jian Zheng, Xiaobai Liu, Libo Liu, Jiajia Chen, Lini Zhao, Xuelei Ruan, Yixue Xue
BACKGROUND: The blood-brain barrier (BBB) strongly restricts the entry of anti-glioma drugs into tumor tissues and thus decreases chemotherapy efficacy. Malignant gliomas are highly invasive tumours that use the perivascular space for invasion and co-opt existing vessels as satellite tumor form. Because regulation of the effect of noncoding RNA on BBB function is attracting growing attention, we investigated the effects of noncoding RNA on the permeability of glioma conditioned normal BBB and the mechanism involved using PIWI-associated RNA piR-DQ590027 as a starting point...
October 11, 2018: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/30299467/a-dietary-carbohydrase-blend-improved-intestinal-barrier-function-and-growth-rate-in-weaned-pigs-fed-higher-fiber-diets
#12
Qingyun Li, Nicholas K Gabler, Crystal L Loving, Stacie A Gould, John F Patience
The objective of this study was to evaluate the effects of dietary xylanase (X) and a carbohydrase enzyme blend (EB: cellulase, ß-glucanase, and xylanase) on nutrient digestibility, intestinal barrier integrity, inflammatory status, and growth performance in weaned piglets fed higher fiber diets. A total of 460 pigs (6.43 ± 0.06 kg BW; F25 × 6.0 Genetiporc) were blocked by initial BW and pens (n = 12 per treatment) were randomly assigned to 1 of 4 dietary treatments. The diets included a higher fiber unsupplemented control diet (CON) and the CON supplemented with 0...
October 8, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/30298533/effect-of-zinc-oxide-sources-and-dosages-on-gut-microbiota-and-integrity-of-weaned-piglets
#13
Wei Wang, Noémie Van Noten, Jeroen Degroote, Agathe Romeo, Pieter Vermeir, Joris Michiels
Zinc oxide (ZnO) supplied at pharmacological dosage in diets of weaned piglets improves growth performance. However, it causes environmental contamination and induces bacterial antibiotic resistance, yet this practice is debated. The effects on gut microbiota and integrity in weaned piglets of conventional ZnO at nutritional and pharmacological dosage (110 and 2,400 mg/kg Zn, respectively) were compared to an alternative ZnO source at 110 and 220 mg/kg Zn. Each of the four treatments was applied to four pens (two piglets/pen; weaning age, 20 days) for 15 days, and piglets were sampled on day 15 to determine indices of gut integrity...
October 8, 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/30296500/cofilin-1-signaling-mediates-epithelial-mesenchymal-transition-by-promoting-actin-cytoskeleton-reorganization-and-cell-cell-adhesion-regulation-in-colorectal-cancer-cells
#14
Annie Cristhine Moraes Sousa-Squiavinato, Murilo Ramos Rocha, Pedro Barcellos-de-Souza, Waldemir Fernandes Souza, Jose Andres Morgado-Diaz
Colorectal cancer (CRC) is frequently a lethal disease because of metastasis. Actin cytoskeletal rearrangement is an essential step in cell migration during activation of the epithelial-mesenchymal transition (EMT) program, which is associated with metastatic properties of cancer cells. Cofilin-1 protein modulates actin dynamics by promoting actin treadmilling, thereby driving membrane protrusion and cell migration and invasion. However, the role of cofilin-1 during EMT in CRC is unknown. Here, we show that cofilin-1 and p-cofilin-1 have distinct subcellular distribution in EMT cells, as determined by super-resolution microscopy images, indicating distinct roles in different areas of cells...
October 5, 2018: Biochimica et biophysica acta. Molecular cell research
https://www.readbyqxmd.com/read/30295909/mesenteric-adipose-tissue-alterations-in-crohn-s-disease-are-associated-with-the-lymphatic-system
#15
Weisong Shen, Yi Li, Yujie Zou, Lei Cao, Xingchen Cai, Jianfeng Gong, Yihan Xu, Weiming Zhu
Background: Mesenteric fat wrapping and thickening are typical characteristics of Crohn's disease (CD). The purpose of this study was to explore the cause of mesenteric adipose hypertrophy and analyze the role of lymphatic vessels in mesenteric adipose tissue in CD. Methods: Twenty-three CD patients who underwent ileocolonic resection were included. In CD patients, specimens were obtained from hypertrophic mesenteric adipose tissue (htMAT) next to the diseased ileum...
October 5, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/30291936/the-organophosphate-pesticide-methamidophos-opens-the-blood-testis-barrier-and-covalently-binds-to-zo-2-in-mice
#16
José Mario Ortega-Olvera, Robert Winkler, Betzabet Quitanilla-Vega, Mineko Shibayama, Bibiana Chávez-Munguía, Dolores Martín-Tapia, Lourdes Alarcón, Lorenza González-Mariscal
Methamidophos (MET) is an organophosphate (OP) pesticide widely used in agriculture in developing countries. MET causes adverse effects in male reproductive function in humans and experimental animals, but the underlying mechanisms remain largely unknown. We explored the effect of MET on mice testes (5 mg/kg/day/4 days), finding that this pesticide opens the blood-testis barrier and perturbs spermatogenesis, generating the appearance of immature germ cells in the epididymis. In the seminiferous tubules, MET treatment changed the level of expression or modified the stage-specific localization of tight junction (TJ) proteins ZO-1, ZO-2, occludin, and claudin-3...
October 3, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/30290210/s1pr2-antagonist-alleviates-oxidative-stress-enhanced-brain-endothelial-permeability-by-attenuating-p38-and-erk1-2-dependent-cpla-2-phosphorylation
#17
Changchun Cao, Li Dai, Junyu Mu, Xiaofei Wang, Yali Hong, Chao Zhu, Lai Jin, Shengnan Li
Both sphingosine-1-phosphate receptor-2 (S1PR2) and cytosolic phospholipase A2 (cPLA2 ) are implicated in the disruption of cerebrovascular integrity in experimental stroke. However, the role of S1PR2 in induction of cPLA2 phosphorylation during cerebral ischemia-induced endothelial dysfunction remains unknown. This study investigated the effect of S1PR2 blockade on oxidative stress-induced cerebrovascular endothelial barrier impairment and explored the possible mechanisms. In bEnd3 cells, cPLA2 inhibitor CAY10502 as well as S1PR2 antagonist JTE013 profoundly suppressed hydrogen peroxide (H2 O2 )-induced changes of paracellular permeability and ZO-1 localization...
October 2, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/30289512/dietary-deoxynivalenol-and-oral-lipopolysaccharide-challenge-differently-affect-intestinal-innate-immune-response-and-barrier-function-in-broiler-chickens
#18
Annegret Lucke, Josef Böhm, Qendrim Zebeli, Barbara U Metzler-Zebeli
Dietary deoxynivalenol (DON) impairs the intestinal immune system and digestive functions of broiler chickens. However, little is known whether increasing doses of DON similarly affect the intestinal functions in different segments of the small intestine in chickens and whether a second oral challenge may potentiate those effects. The present objective was to investigate the effect of increasing dietary DON concentrations on the relative expression of genes for tight junction proteins, mucins, toll-like receptors (TLR), and cytokines in duodenum and jejunum, jejunal mucosal permeability, as well as on α-1-acid glycoprotein and IgA in serum with or without an additional oral lipopolysaccharide (LPS) challenge...
October 5, 2018: Journal of Animal Science
https://www.readbyqxmd.com/read/30286467/omi-htra2-regulates-a-mitochondria-dependent-apoptotic-pathway-in-a-murine-model-of-septic-encephalopathy
#19
Pengfei Wang, Yueyu Hu, Danhua Yao, Yousheng Li
BACKGROUND/AIMS: the pathogenesis of sepsis-associated encephalopathy (SAE) is multifactorial, involving neurotransmitter alterations, inflammatory cytokines, oxidative damage, mitochondrial dysfunction, apoptosis, and other factors. Mitochondria are major producers of reactive oxygen species, resulting in cellular injury. Omi/HtrA2 is a proapoptotic mitochondrial serine protease involved in caspase-dependent cell death; it is translocated from mitochondria to the cytosol after an apoptotic insult...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/30284609/anisomycin-a-jnk-and-p38-activator-suppresses-cell-cell-junction-formation-in-2d-cultures-of-k38-mouse-keratinocyte-cells-and-reduces-claudin-7-expression-with-an-increase-of-paracellular-permeability-in-3d-cultures
#20
Misaki Nikaido, Takahito Otani, Norio Kitagawa, Kayoko Ogata, Hiroshi Iida, Hisashi Anan, Tetsuichiro Inai
Keratinocytes in the oral mucosal epithelium, which is a non-keratinized stratified epithelium, are exposed to various stimuli from the oral cavity. JNK and p38 are stress-activated mitogen-activated protein kinases (MAPKs) that are phosphorylated by various stimuli and are involved in the assembly and disassembly of tight junctions (TJs) in keratinocytes. Therefore, we investigated the effects of stress-activated MAPKs on TJs in a mouse keratinocyte cell line during cell-cell junction formation in two-dimensional (2D) cultures or stratification to form non-keratinized epithelium in 3D cultures...
October 4, 2018: Histochemistry and Cell Biology
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