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https://www.readbyqxmd.com/read/30098333/tusc3-accelerates-cancer-growth-and-induces-epithelial-mesenchymal-transition-by-upregulating-claudin-1-in-non-small-cell-lung-cancer-cells
#1
Siyang Feng, Jianxue Zhai, Di Lu, Jie Lin, Xiaoying Dong, Xiguang Liu, Hua Wu, Anja C Roden, Giovanni Brandi, Simona Tavolari, Andrea Bille, Kaican Cai
Lung cancer is the most frequent cause of cancer-related deaths worldwide, but its molecular pathogenesis is poorly understood. The tumor suppressor candidate 3 (TUSC3) gene is located on chromosome 8p22 and is universally acknowledged as a cancer suppressor. However, our research has demonstrated that TUSC3 expression is significantly upregulated in non-small-cell lung cancer compared to benign controls. In this study, we analyzed the consequences of TUSC3 knockdown or overexpression on the biological functions of non-small-cell lung cancer cell lines...
August 8, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/30090549/effect-of-deoxynivalenol-on-apoptosis-barrier-function-and-expression-levels-of-genes-involved-in-nutrient-transport-mitochondrial-biogenesis-and-function-in-ipec-j2-cells
#2
Peng Liao, Meifang Liao, Ling Li, Bie Tan, Yulong Yin
This study was conducted to determine the effect of 200 ng mL-1 and 2000 ng mL-1 deoxynivalenol (DON) on apoptosis, barrier function, nutrient transporter gene expression, and free amino acid variation as well as on mitochondrial biogenesis and function-related gene expression in the intestinal porcine epithelial cell line J2 (IPEC-J2) for 6 h, 12 h, and 24 h. Exposure to 200 ng mL-1 DON inhibited the cell viability and promoted cell cycle progression from the G2/M phase to the S phase ( P < 0.05). The data showed that the IPEC-J2 cell content of free amino acids, such as valine, methionine, leucine, and phenylalanine, was increased ( P < 0...
November 1, 2017: Toxicology Research
https://www.readbyqxmd.com/read/30089113/naturally-occurring-canine-invasive-urothelial-carcinoma-harbors-luminal-and-basal-transcriptional-subtypes-found-in-human-muscle-invasive-bladder-cancer
#3
Deepika Dhawan, Noah M Hahn, José A Ramos-Vara, Deborah W Knapp
There is growing evidence that molecular subtypes (e.g. luminal and basal subtypes) affect the prognosis and treatment response in patients with muscle invasive urinary bladder cancer (invasive urothelial carcinoma, iUC). Modeling these subtypes in pre-clinical animal studies is essential, but it is challenging to produce these subtypes, along with other critical host and tumor features, in experimentally-induced animal models. This study was conducted to determine if luminal and basal molecular subtypes are present in naturally-occurring canine iUC, a cancer that mimics the human condition in other key aspects...
August 8, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/30086341/cell-junctions-in-the-prostate-an-overview-about-the-effects-of-endocrine-disrupting-chemicals-edcs-in-different-experimental-models
#4
REVIEW
Wellerson R Scarano, Cristiane F Pinho, Lorenzo Pissinatti, Bianca F Gonçalves, Leonardo O Mendes, Silvana G P Campos
Throughout the last decades, increasing exposure to environmental Endocrine Disruptors Chemicals (EDCs) has been associated with the occurrence of male reproductive disorders, such as impairment of prostate development and function, increase of susceptibility to oncogenesis, Epithelial-Mesenchymal Transition and the metastatic invasive potential. Nevertheless, few studies address the mechanisms involved in these alterations, especially those related to cell junctions, which are hormonally regulated and, therefore, possible EDCs targets...
August 4, 2018: Reproductive Toxicology
https://www.readbyqxmd.com/read/30085304/direct-fed-glucose-oxidase-and-its-combination-with-b-amyloliquefaciens-sc06-on-growth-performance-meat-quality-intestinal-barrier-antioxidative-status-and-immunity-of-yellow-feathered-broilers
#5
Yuanyuan Wang, Yibing Wang, Han Xu, Xiaoqiang Mei, Li Gong, Baikui Wang, Weifen Li, Shouqun Jiang
This experiment investigated the effects of dietary glucose oxidase (GOD) and its combination with B. amyloliquefaciens SC06 (BaSC06) on the growth performance, meat quality, intestinal physical barrier, antioxidative status and immunity of male Lingnan yellow-feathered broilers. A total of 720 1-d-old broilers were assigned into 4 treatments with 6 replicates per treatment (30 birds per replicate): (1) basal diet (Ctr), (2) basal diet with 200 mg/kg enramycin (ER), (3) basal diet with 75 U/kg GOD, and (4) GOD diet (75U/kg) supplemented with 1 × 105 colony-forming units BaSC06/kg feed (GB), for an experimental duration of 52 d...
August 3, 2018: Poultry Science
https://www.readbyqxmd.com/read/30084485/epigenetics-of-fragile-x-syndrome-and-fragile-x-related-disorders
#6
REVIEW
Claudine M Kraan, David E Godler, David J Amor
The fragile X mental retardation 1 gene (FMR1)-related disorder fragile X syndrome (FXS) is the most common heritable form of cognitive impairment and the second most common cause of comorbid autism. FXS usually results when a premutation trinucleotide CGG repeat in the 5' untranslated region of the FMR1 gene (CGG 55-200) expands over generations to a full mutation allele (CGG >200). This expansion is associated with silencing of the FMR1 promoter via an epigenetic mechanism that involves DNA methylation of the CGG repeat and the surrounding regulatory regions...
August 7, 2018: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/30082157/expression-and-prognostic-significance-of-epithelial-mesenchymal-transition-related-markers-and-phenotype-in-serous-ovarian-cancer
#7
In Hye Song, Kyu-Rae Kim, Sehun Lim, Seok-Hyung Kim, Chang Ohk Sung
The epithelial-mesenchymal transition (EMT) is known to be associated with carcinoma invasion and metastasis. Previous studies have demonstrated that the expression of EMT-related proteins in carcinoma cells in many organs is associated with a higher histologic grade and a poor prognosis. However, the clinical significance of EMT in ovarian cancers is controversial. Formalin-fixed and paraffin-embedded tumor samples of 198 high-grade serous carcinomas (HGSCs) and 13 serous borderline tumors or low-grade serous carcinomas (SBT/LGSCs) of the ovary were analyzed...
July 25, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/30081051/involvement-of-the-p38-mapk-signaling-pathway-in-overexpression-of-matrix-metalloproteinase-9-during-the-course-of-brain-edema-in-1-2-dichloroethane-intoxicated-mice
#8
Xiaoxia Jin, Yingjun Liao, Xiaoqiong Tan, Jingjing Guo, Gaoyang Wang, Fenghong Zhao, Yaping Jin
Accumulated data have revealed that subacute poisoning of 1,2-dichloroethane (1,2-DCE), an industrial solvent used in some countries can cause encephalopathy, in which brain edema is the main pathological change. However, the underlying mechanisms are unclear. In the present study, we hypothesized that the p38 MAPK (p38) signaling pathway could be activated in 1,2-DCE-intoxicated mice, which in turn stimulates transcription factors, such as nuclear factor-κB (NF-κB) and activator protein-1 (AP-1), and then enhances the expression of proinflammatory factors, including matrix metalloproteinase-9 (MMP-9), finally leading to blood-brain barrier (BBB) disruption and brain edema formation...
August 3, 2018: Neurotoxicology
https://www.readbyqxmd.com/read/30080134/extended-spectrum-%C3%AE-lactamase-encoding-genes-are-spreading-on-a-wide-range-of-escherichia-coli-plasmids-existing-prior-to-the-use-of-third-generation-cephalosporins
#9
Catherine Branger, Alice Ledda, Typhaine Billard-Pomares, Benoît Doublet, Stéphanie Fouteau, Valérie Barbe, David Roche, Stéphane Cruveiller, Claudine Médigue, Miguel Castellanos, Dominique Decré, Laurence Drieux-Rouze, Olivier Clermont, Jérémy Glodt, Olivier Tenaillon, Axel Cloeckaert, Guillaume Arlet, Erick Denamur
To understand the evolutionary dynamics of extended-spectrum β-lactamase (ESBL)-encoding genes in Escherichia coli, we undertook a comparative genomic analysis of 116 whole plasmid sequences of human or animal origin isolated over a period spanning before and after the use of third-generation cephalosporins (3GCs) using a gene-sharing network approach. The plasmids included 82 conjugative, 22 mobilizable and 9 non-transferable plasmids and 3 P-like bacteriophages. ESBL-encoding genes were found on 64 conjugative, 6 mobilizable, 2 non-transferable plasmids and 2 P1-like bacteriophages, indicating that these last three types of mobile elements also play a role, albeit modest, in the diffusion of the ESBLs...
August 6, 2018: Microbial Genomics
https://www.readbyqxmd.com/read/30076740/oncostatin-m-induced-blood-brain-barrier-impairment-is-due-to-prolonged-activation-of-stat3-signaling-in-vitro
#10
Fuyuko Takata, Shinya Dohgu, Junichi Matsumoto, Takashi Machida, Shinya Sakaguchi, Ikuya Kimura, Atsushi Yamauchi, Yasufumi Kataoka
Oncostatin M (OSM) is a member of the interleukin (IL)-6 family cytokines. We previously demonstrated that OSM induces blood-brain barrier (BBB) impairment. However, functional characterization of IL-6 family cytokines in BBB regulation and the cytokine-related intracellular signaling pathway remain unclear. In this study, we demonstrate that among IL-6 family cytokines, including IL-6 and leukemia inhibitory factor (LIF), OSM is the most potent molecule for inducing BBB dysfunction via prolonged activation of signal transducer and activator of transcription (STAT) 3 following Janus-activated kinase (JAK) activation...
August 4, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/30073201/loss-of-blood-brain-barrier-integrity-in-a-kcl-induced-model-of-episodic-headache-enhances-cns-drug-delivery
#11
Karissa E Cottier, Emily A Galloway, Elisa C Calabrese, Margaret E Tome, Erika Liktor-Busa, John Kim, Thomas P Davis, Todd W Vanderah, Tally M Largent-Milnes
Cortical spreading depression (CSD) in the CNS is suggested as a common mechanism contributing to headache. Despite strong evidence for CNS involvement in headache disorders, drug development for headache disorders remains focused on peripheral targets. Difficulty in delivering drugs across the blood-brain barrier (BBB) may partially account for this disparity. It is known, however, that BBB permeability is increased during several CNS pathologies. In this study, we investigated BBB changes in response to KCl-induced CSD events and subsequent allodynia in rats...
July 2018: ENeuro
https://www.readbyqxmd.com/read/30073151/moderate-dietary-protein-restriction-optimized-gut-microbiota-and-mucosal-barrier-in-growing-pig-model
#12
Xiyue Chen, Peixia Song, Peixin Fan, Ting He, Devin Jacobs, Crystal L Levesque, Lee J Johnston, Linbao Ji, Ning Ma, Yiqiang Chen, Jie Zhang, Jinshan Zhao, Xi Ma
Appropriate protein concentration is essential for animal at certain stage. This study evaluated the effects of different percentages of dietary protein restriction on intestinal health of growing pigs. Eighteen barrows were randomly assigned to a normal (18%), low (15%), and extremely low (12%) dietary protein concentration group for 30 days. Intestinal morphology and permeability, bacterial communities, expressions, and distributions of intestinal tight junction proteins, expressions of biomarkers of intestinal stem cells (ISCs) and chymous bacterial metabolites in ileum and colon were detected...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/30066013/the-epithelial-barrier-protecting-properties-of-a-soy-hydrolysate
#13
Mensiena B G Kiewiet, Martín I González Rodríguez, Renske Dekkers, Marjan Gros, Laurien H Ulfman, Andre Groeneveld, Paul de Vos, Marijke M Faas
Enhancing the epithelial barrier function could be a possible strategy to prevent food allergy or reduce its symptoms. Soy hydrolysates containing bioactive peptides could be instrumental in this. In this study, the protective effects of pretreatment with 6 soy hydrolysates on calcium ionophore A23187-induced TEER reduction were studied in T84 cells. The effects of the most potent soy hydrolysate on tight junction gene expression were studied. In order to identify the underlying pathways involved, the barrier disruptor specificity of the effect was studied by comparing the protective effects on TEER and Lucifer Yellow flux after the exposure to barrier disruptors that work via different intracellular pathways, i...
August 1, 2018: Food & Function
https://www.readbyqxmd.com/read/30065832/antiwrinkle-and-antimelanogenesis-activity-of-the-ethanol-extracts-of-lespedeza-cuneata-g-don-for-development-of-the-cosmeceutical-ingredients
#14
Jongsung Lee, Jun Ji, See-Hyoung Park
To develop the ingredient with the cosmeceutical function, the antiwrinkle and antimelanogenesis effects of the ethanol extract of Lespedeza cuneata G. Don were investigated. DPPH radical scavenging activity was significantly increased with the extract of L. cuneata G. Don. Cell viability on CCD986Sk human fibroblast was also increased by the ethanol extract of L. cuneata G. Don. The inhibitory function of the extract of L. cuneata G. Don on collagenase, elastase, and tyrosinase was evaluated. Protein expression level of Claudin-1, Occludin, and ZO-1 was up-regulated in HaCaT human keratinocyte by the extract of L...
July 2018: Food Science & Nutrition
https://www.readbyqxmd.com/read/30065236/a-polysaccharide-isolated-from-dictyophora-indusiata-promotes-recovery-from-antibiotic-driven-intestinal-dysbiosis-and-improves-gut-epithelial-barrier-function-in-a-mouse-model
#15
Sadia Kanwal, Thomson Patrick Joseph, Lawrence Owusu, Ren Xiaomeng, Li Meiqi, Xin Yi
Despite the tremendous biological activity of polysaccharides from the mushroom Dictyophora indusiata , its role in the restoration of gut microbiota has not yet been explored. The present study aimed to investigate whether D. indusiata polysaccharide (DIP) could modulate the recovery of gut microbiota composition and intestinal barrier function after broad-spectrum antibiotic-driven dysbiosis. Alteration and restoration in the microbial communities were elucidated by the Illumina MiSeq platform. Colon histology, expression of tight-junction associated proteins, and serum/tissue endotoxin and cytokine levels were evaluated...
July 31, 2018: Nutrients
https://www.readbyqxmd.com/read/30059973/scn5a-mutations-in-442-neonates-and-children-genotype-phenotype-correlation-and-identification-of-higher-risk-subgroups
#16
Alban-Elouen Baruteau, Florence Kyndt, Elijah R Behr, Arja S Vink, Matthias Lachaud, Anna Joong, Jean-Jacques Schott, Minoru Horie, Isabelle Denjoy, Lia Crotti, Wataru Shimizu, Johan M Bos, Elizabeth A Stephenson, Leonie Wong, Dominic J Abrams, Andrew M Davis, Annika Winbo, Anne M Dubin, Shubhayan Sanatani, Leonardo Liberman, Juan Pablo Kaski, Boris Rudic, Sit Yee Kwok, Claudine Rieubland, Jacob Tfelt-Hansen, George F Van Hare, Béatrice Guyomarc'h-Delasalle, Nico A Blom, Yanushi D Wijeyeratne, Jean-Baptiste Gourraud, Hervé Le Marec, Junichi Ozawa, Véronique Fressart, Jean-Marc Lupoglazoff, Federica Dagradi, Carla Spazzolini, Takeshi Aiba, David J Tester, Laura A Zahavich, Virginie Beauséjour-Ladouceur, Mangesh Jadhav, Jonathan R Skinner, Sonia Franciosi, Andrew D Krahn, Mena Abdelsayed, Peter C Ruben, Tak-Cheung Yung, Michael J Ackerman, Arthur A Wilde, Peter J Schwartz, Vincent Probst
Aims: To clarify the clinical characteristics and outcomes of children with SCN5A-mediated disease and to improve their risk stratification. Methods and results: A multicentre, international, retrospective cohort study was conducted in 25 tertiary hospitals in 13 countries between 1990 and 2015. All patients ≤16 years of age diagnosed with a genetically confirmed SCN5A mutation were included in the analysis. There was no restriction made based on their clinical diagnosis...
July 27, 2018: European Heart Journal
https://www.readbyqxmd.com/read/30057893/protective-ability-of-biogenic-antimicrobial-peptide-microcin-j25-against-enterotoxigenic-escherichia-coli-induced-intestinal-epithelial-dysfunction-and-inflammatory-responses-ipec-j2-cells
#17
Haitao Yu, Xiuliang Ding, Lijun Shang, Xiangfang Zeng, Hongbin Liu, Ning Li, Shuo Huang, Yuming Wang, Gang Wang, Shuang Cai, Meixia Chen, Crystal L Levesque, Lee J Johnston, Shiyan Qiao
Poison of intestinal induce severe health problems in human infants and young animals due to contaminating foods and feedstuffs. With the emergence of public health concerns and high-speed diffuse of drug-opposition of bacteria, the adoption of antimicrobial peptides as potential candidates in treating pathogen infections raised up. Nature Microcin J25 (MccJ25), a class of lasso peptides separated from a fecal strain of E. coli , has been replied to display powerful antimicrobial behavior. Herein, the study was to assess the usefulness of biogenic MccJ25 in the prophylaxis of ETEC K88 infection in IPEC-J2 cells...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/30054336/a-transcriptome-wide-association-study-among-97-898-women-to-identify-candidate-susceptibility-genes-for-epithelial-ovarian-cancer-risk
#18
Yingchang Lu, Alicia Beeghly-Fadiel, Lang Wu, Xingyi Guo, Bingshan Li, Joellen M Schildkraut, Hae Kyung Im, Yian Ann Chen, Jennifer B Permuth, Brett M Reid, Jamie K Teer, Kirsten B Moysich, Irene L Andrulis, Hoda Anton-Culver, Banu K Arun, Elisa V Bandera, Rosa B Barkardottir, Daniel R Barnes, Javier Benitez, Line Bjørge, James Brenton, Ralf Butzow, Trinidad Caldes, Maria A Caligo, Ian G Campbell, Jenny Chang-Claude, Kathleen B M Claes, Fergus J Couch, Daniel W Cramer, Mary B Daly, Anna DeFazio, Joe Dennis, Orland Díez, Susan M Domchek, Thilo Dork, Douglas F Easton, Diana M Eccles, Peter A Fasching, Renée T Fortner, George Fountzilas, Eitan Friedman, Patricia A Ganz, Judy Garber, Graham G Giles, Andrew K Godwin, David E Goldgar, Marc T Goodman, Mark H Greene, Jacek Gronwald, Ute Hamann, Florian Heitz, Michelle A T Hildebrandt, Claus K Høgdall, Antoinette Hollestelle, Peter J Hulick, David G Huntsman, Evgeny N Imyanitov, Claudine Isaacs, Anna Jakubowska, Paul James, Beth Y Karlan, Linda E Kelemen, Lambertus A Kiemeney, Susanne K Kjaer, Ava Kwong, Nhu D Le, Goska Leslie, Fabienne Lesueur, Douglas A Levine, Amalia Mattiello, Taymaa May, Lesley McGuffog, Iain A McNeish, Melissa A Merritt, Francesmary Modugno, Marco Montagna, Susan L Neuhausen, Heli Nevanlinna, Finn C Cilius Nielsen, Liene Nikitina-Zake, Robert L Nussbaum, Kenneth Offit, Edith Olah, Olufunmilayo I Olopade, Sara H Olson, Håkan Olsson, Ana Osorio, Sue K Park, Michael T Parsons, Petra H M Peeters, Tanja Pejovic, Paolo Peterlongo, Catherine M Phelan, Miguel Angel Pujana, Susan J Ramus, Gad Rennert, Harvey Risch, Gustavo C Rodriguez, Cristina Rodríguez-Antona, Isabelle Romieu, Matti A Rookus, Mary Anne Rossing, Iwona K Rzepecka, Dale P Sandler, Rita K Schmutzler, Veronica W Setiawan, Priyanka Sharma, Weiva Sieh, Jacques Simard, Christian F Singer, Honglin Song, Melissa C Southey, Amanda B Spurdle, Rebecca Sutphen, Anthony J Swerdlow, Manuel R Teixeira, Soo H Teo, Mads Thomassen, Marc Tischkowitz, Amanda E Toland, Antonia Trichopoulou, Nadine Tung, Shelley S Tworoger, Elizabeth J van Rensburg, Adriaan Vanderstichele, Ana Vega, Digna Velez Edwards, Penelope M Webb, Jeffrey N Weitzel, Nicolas Wentzensen, Emily White, Alicja Wolk, Anna H Wu, Drakoulis Yannoukakos, Kristin K Zorn, Simon A Gayther, Antonis C Antoniou, Andrew Berchuck, Ellen L Goode, Georgia Chenevix-Trench, Thomas A Sellers, Paul D P Pharoah, Wei Zheng, Jirong Long
Large-scale genome-wide association studies (GWAS) have identified approximately 35 loci associated with epithelial ovarian cancer (EOC) risk. The majority of GWAS-identified disease susceptibility variants are located in non-coding regions, and causal genes underlying these associations remain largely unknown. Here we performed a transcriptome-wide association study to search for novel genetic loci and plausible causal genes at known GWAS loci. We used RNA sequencing data (68 normal ovarian-tissue samples from 68 individuals and 6,124 cross-tissue samples from 369 individuals) and high-density genotyping data from European descendants of the Genotype-Tissue Expression (GTEx V6) project to build ovarian and cross-tissue models of genetically regulated expression using elastic net methods...
July 27, 2018: Cancer Research
https://www.readbyqxmd.com/read/30050428/the-combination-of-human-urinary-kallidinogenase-and-mild-hypothermia-protects-adult-rats-against-hypoxic-ischemic-encephalopathy-induced-injury-by-promoting-angiogenesis-and-regeneration
#19
Xiaoya Gao, Haiting Xie, Shuzhen Zhu, Bin Yu, Ying Xian, Qian Ouyang, Yabin Ji, Xiaohua Yang, Chunyan Wen, Penghua Wang, Yufeng Tong, Qing Wang
Objectives : Human Urinary Kallidinogenase (HUK) is a tissue kallikrein that plays neuroprotective role in ischemic conditions via different mechanisms. Mild hypothermia (MH) is another robust neuroprotectant that reduces mortality but does not profoundly ameliorate the neurological outcome in hypoxic-ischemic encephalopathy (HIE) patients. However, whether the combination of HUK and MH can be used as a promising neuroprotective treatment in HIE is unknown. Methods : One-hundred and forty-four adult Wistar rats were randomly divided into five groups: Sham, HIE, HUK, MH and a combination of HUK and MH treatment...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/30043038/evaluation-of-the-concurrent-trajectories-of-cardiometabolic-risk-factors-in-the-14-years-before-dementia
#20
Maude Wagner, Catherine Helmer, Christophe Tzourio, Claudine Berr, Cécile Proust-Lima, Cécilia Samieri
Importance: Cardiometabolic risk factors have been associated with an increased risk of dementia; yet, the optimal targets and time window for the management of cardiometabolic health to prevent dementia remain unknown. Objectives: To model concurrently and compare the trajectories of cardiometabolic risk factors up to 14 years preceding diagnosis in individuals with dementia and matched controls free of dementia. Design, Setting, and Participants: A case-control study nested within the Three-City study, a French population-based cohort of older persons (≥65 years), included 6 home visits with neuropsychological testing between 1999 and 2014...
July 24, 2018: JAMA Psychiatry
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