keyword
https://read.qxmd.com/read/38533288/protective-effect-of-baclofen-on-ovarian-cystogenesis-and-morphine-induced-lipid-profile-change-in-female-rats
#21
JOURNAL ARTICLE
Zahra Jamshidi, Manizheh Karami, Mohsen Khalili, Mehrdad Roghani
INTRODUCTION: Morphine induces ovarian cysts that cause obesity and disrupt sex hormone secretion. Baclofen, a gamma-aminobutyric acid receptor agonist, can help regulate sex hormones and reduce harmful blood lipids by protecting against morphine-induced gamma-aminobutyric acid inhibition. We investigated the prophylactic effect of baclofen in rats receiving morphine by comparing with the untreated groups. MATERIALS AND METHODS: Forty eight female Wistar rats were randomly divided into several groups, including control (saline 1 mL/kg, i...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533285/the-hidden-battle-within-shedding-light-on-the-co-existence-of-sarcopenia-and-sarcopenic-obesity-among-participants-with-type-2-diabetes-in-a-tertiary-care-hospital-gujarat
#22
JOURNAL ARTICLE
M Yogesh, Mansi Mody, Naresh Makwana, Samarth Rabadiya, Jenish Patel, Samyak Shah
INTRODUCTION: Type 2 diabetes (T2DM) is characterised by chronic hyperglycaemia due to abnormal insulin secretion and/or utilisation. Currently, sarcopenia has emerged as a new complication of T2DM, which increases the risk of physical disability, and even death. The study aims to estimate the prevalence of sarcopenia and sarcopenic obesity (SO) as well as their association with various other factors related to T2DM. METHODS: The study was an observational hospital-based cross-sectional study conducted among diabetic patients who came to the non-communicable diseases (NCD) clinic of a tertiary care hospital in Gujarat, India, from April 2023 to June 2023...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533284/utility-of-colour-flow-doppler-ultrasonography-to-differentiate-gestational-transient-thyrotoxicosis-and-graves-disease-in-pregnancy
#23
JOURNAL ARTICLE
Vijay Sheker Reddy Danda, Piyush Lodha, Srinivas Rao Paidipally, Sandeep Reddy Devireddy
INTRODUCTION: Accurate diagnosis of the etiology of thyrotoxicosis in pregnancy is important to guide appropriate treatment. The role of thyroid blood flow velocities by color Doppler to differentiate between Graves' disease (GD) in pregnancy and gestational transient thyrotoxicosis (GTT) is not well explored. This study evaluated inferior thyroid artery (ITA)-peak systolic velocity (PSV) as a marker for differential diagnosis of thyrotoxicosis in pregnancy. METHODS: Fifty-six pregnant patients with thyrotoxicosis (30 with GTT and 26 with GD) along with 30 age-matched healthy euthyroid pregnant subjects were enrolled...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533281/efficacy-of-pistacia-lentiscus-plant-rumi-mastagi-in-comparison-to-levosulpiride-in-patients-with-diabetic-gastroparesis-a-double-blind-non-inferior-randomised-control-trial-study
#24
JOURNAL ARTICLE
Ajaypal Singh, Ravi Kant, Rohit Raina, Vandana Dhingra, Rajeev Nema, Mukesh Chand Bairwa, Varsha Kanwar, Rifika L Sukhes Mukherjee, Anissa Atif Mirza, Mayank Agarwal
INTRODUCTION: Gastrointestinal neuropathies are frequently found in diabetic patients. The pathogenesis of diabetic gastroparesis (DG) is multifactorial. The usual treatment for DG includes dietary modifications, prokinetic and antiemetic agents. There is increasing demand for more effective medicines to treat DG. The current study was conducted on the Pistacia lentiscus stem extract to add to the armamentarium of DG treatment and to find the efficacy of P. lentiscus plant extract (mastic gum) in comparison to levosulpiride in DG for improvement in gastroparesis symptoms and gastric emptying scintigraphy (GES) in a single centric double-blind non-inferiority randomised control trial...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533277/heterophilic-interference-of-rheumatoid-factor-in-tsh-immunometric-assay-a-cross-sectional-observational-study
#25
JOURNAL ARTICLE
Shaikh N Nayeemuddin, Akash Panigrahi, Rana Bhattacharjee, Subhankar Chowdhury
INTRODUCTION: Considering the inherent vulnerability of immunoassays for heterophilic interference and the potential of Rheumatoid Factor (RF) to act as a heterophile-like antibody, we conducted this study to investigate if RF leads to any such heterophilic interference in seropositive rheumatoid arthritis (RA) patients. The study was done on the TSH assay as it is a noncompetitive, double antibody sandwich assay, which is known to be vulnerable to heterophilic interference. METHODS: In this cross-sectional observational study, eighty-four consecutive newly diagnosed RF-positive RA patients underwent TSH, Free T4, and anti-TPO estimation using the chemiluminescence technique (CLIA) on Siemens Immulite 1000 platform...
2024: Indian Journal of Endocrinology and Metabolism
https://read.qxmd.com/read/38533266/the-regulation-role-of-the-gut-islets-axis-in-diabetes
#26
REVIEW
Songtao Yang, Jie Cao, Chuan Sun, Li Yuan
The gut-islets axis is an important endocrine signaling axis that regulates the function of islets by modulating the gut micro-environment and its endocrine metabolism. The discovery of intestinal hormones, such as GLP-1 and GIP, has established a preliminary link between the gut and the islet, paving the way for the development of GLP-1 receptor agonists based on the regulation theory of the gut-islets axis for diabetes treatment. This discovery has created a new paradigm for diabetes management and rapidly made the regulation theory of the gut-islets axis a focal point of research attention...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38532931/hemophagocytic-lymphohistiocytosis-during-treatment-of-intracranial-multifocal-germinoma-a-case-report-and-literature-review
#27
Ting Guo, Zichun Liu, Yixin Chen, Yangyang Cheng, Kaitong He, Xin Lin, Mingzhu Wang, Yihua Sun
Hemophagocytic lymphohistiocytosis (HLH), also known as hemophagocytic syndrome (HPS), is a benign histiocytosis with hyperreactive proliferation of the mononuclear phagocyte system caused by immune function abnormalities, which often occurs under the background of genetic mutations, inflammation, infection or tumors. Because the research on malignancy-associated HLH (M-HLH) is focused on hematological malignancies, reports on HLH secondary to solid tumors are rare. In this case, we report a 14-year-old girl who developed HLH during treatment for intracranial multifocal germinoma, and the disease was controlled after hormone combined with etoposide(VP-16) and other related treatments...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38532898/cushing-s-syndrome-during-pregnancy-two-case-reports
#28
Sumita Cholekho, Yuke Liu, Huiwen Tan
BACKGROUND: Cushing's syndrome (CS) during pregnancy is a rare endocrine disorder characterized by hypercortisolism, which is significantly associated with maternal-fetal complications. Despite its rarity, CS during pregnancy may be related to a high risk of complications for both the mother and fetus.The aim of the present case study is to update the diagnostic approach to CS during pregnancy and the therapeutic strategies for this medical condition to minimize maternal-fetal complications...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38532322/glp-1-glp-1ras-new-options-for-the-drug-treatment-of-nafld
#29
JOURNAL ARTICLE
Haoran Jiang, Linquan Zang
Non-alcoholic fatty liver disease (NAFLD) has recently emerged as a global public health concern. Currently, the cornerstone of NAFLD treatment is lifestyle modification and, if necessary, weight loss. However, compliance is a challenge, and this approach alone may not be sufficient to halt and treat the more serious disease development, so medication is urgently needed. Nevertheless, no medicines are approved to treat NAFLD. Glucagon-like peptide-1 (GLP-1) is an enteropeptide hormone that inhibits glucagon synthesis, promotes insulin secretion, and delays gastric emptying...
2024: Current Pharmaceutical Design
https://read.qxmd.com/read/38532109/exogenous-strigolactone-enhanced-the-drought-tolerance-of-pepper-capsicum-chinense-by-mitigating-oxidative-damage-and-altering-the-antioxidant-mechanism
#30
JOURNAL ARTICLE
Huangying Shu, Kaijing Xu, Xiangrui Li, Jiancheng Liu, Muhammad Ahsan Altaf, Huizhen Fu, Xu Lu, Shanhan Cheng, Zhiwei Wang
Exogenous SL positively regulates pepper DS by altering the root morphology, photosynthetic character, antioxidant enzyme activity, stomatal behavior, and SL-related gene expression. Drought stress (DS) has always been a problem for the growth and development of crops, causing significant negative impacts on crop productivity. Strigolactone (SL) is a newly discovered class of plant hormones that are involved in plants' growth and development and environmental stresses. However, the role of SL in response to DS in pepper remains unknown...
March 26, 2024: Plant Cell Reports
https://read.qxmd.com/read/38532073/long-term-pasireotide-therapy-in-acromegaly-extensive-real-life-experience-of-a-referral-center
#31
JOURNAL ARTICLE
R Pirchio, R S Auriemma, A Vergura, R Pivonello, A Colao
PURPOSE: Pasireotide is a novel therapeutic option for patients with acromegaly resistant to first-generation somatostatin receptor ligands. To date, real-life data are still scant, therefore, the aim of the current study is to evaluate the impact of long-term pasireotide therapy on disease control, pituitary tumor size, gluco-insulinemic and lipid profile in a real-life setting. METHODS: Retrospective study of data prospectively collected, evaluating hormonal, tumoral, and metabolic data of 28 patients with acromegaly administered with pasireotide in a pituitary tertiary referral center...
March 26, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38531793/characterizing-the-efficacy-and-safety-of-chemotherapy-plus-everolimus-in-her2-negative-metastatic-breast-cancer-harboring-altered-pi3k-akt-mtor
#32
JOURNAL ARTICLE
Rong Wang, Qiao-Yan Zhu, Wei-Wu Ye, Yuan Huang, Zhan-Hong Chen, Ya-Bing Zheng, Xiao Zou, Jian Wang, Dan-Lu Jiang, Xiao-Jia Wang, Zheng-Yang Xu, Wen-Ming Cao
BACKGROUND: The clinical outcomes of chemotherapy (CT) for the treatment of metastatic triple-negative (TN) and hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) metastatic breast cancer (mBC) have proven to be disappointing. The phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway, a tumor-promoting signaling cascade frequently mutated in breast cancer (BC), has been implicated in chemoresistance...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531540/endometriosis-associated-ovarian-cancer-a-different-clinical-entity
#33
JOURNAL ARTICLE
Umberto Leone Roberti Maggiore, G Bogani, Biagio Paolini, Fabio Martinelli, Giulia Chiarello, Ludovica Spanò Bascio, Valentina Chiappa, Simone Ferrero, Antonino Ditto, Francesco Raspagliesi
OBJECTIVE: To compare survival outcomes and patterns of recurrence between endometriosis-associated ovarian cancer patients and non-endometriosis-associated ovarian cancer patients. METHODS: This retrospective study included data of consecutive patients with endometrioid or clear cell ovarian cancer treated at the Fondazione IRCCS Istituto Nazionale dei Tumori di Milano between January 2010 and June 2021. Patients were assigned to one of two groups according to the absence or presence of endometriosis together with ovarian cancer at final histological examination...
March 25, 2024: International Journal of Gynecological Cancer
https://read.qxmd.com/read/38531528/regulatory-and-therapeutic-implications-of-competing-endogenous-rna-network-in-breast-cancer-progression-and-metastasis-a-review
#34
REVIEW
I Saranya, V Sowfika Dharshini, R L Akshaya, P Sakthi Subhashini, N Selvamurugan
Breast cancer (BC) is a global health concern, and development of diagnostic tools and targeted treatments for BC remains challenging. Therapeutic approaches for BC often involve a combination of surgery, radiation therapy, chemotherapy, targeted therapy, and hormone therapy. In recent years, there has been a growing interest in the role of noncoding RNAs (ncRNAs), including long ncRNAs (lncRNAs) and microRNAs (miRNAs), in BC and their therapeutic implications. Various biological processes such as cell proliferation, migration, and apoptosis rely on the activities of these ncRNAs, and their dysregulation has been implicated in BC progression...
March 24, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38531432/the-chemometrics-analysis-and-integrated-pharmacology-approach-to-decipher-the-effect-and-mechanism-between-raw-and-processed-cistanche-tubulosa
#35
JOURNAL ARTICLE
Xing-Yue Zhang, Qi-Wu Jiang, Su-Han Yang, Ping Li, Zhi-Yong Chang, Fei Li
ETHNOPHARMACOLOGICAL RELEVANCE: Cistanche tubulosa (CT) is the dried fleshy stem with scaly leaves of Cistanche tubiflora (Schenk) Wight, which has the effects of tonifying the kidney-yang, benefiting the vital essence and blood, and moisturizing the intestines and laxatives. There are differences in the activity of CT before and after processing, but the mechanism of processing is not clear. AIM OF THE STUDY: The study aimed to compare the strength of action of CT before and after yellow-wine processing in the treatment of constipation and kidney yang deficiency and to identify the active ingredients responsible for the differences in activity before and after yellow-wine processing...
March 24, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38531396/practices-in-the-prescription-of-antiseizure-medications-is-it-time-to-change
#36
JOURNAL ARTICLE
Lécio Figueira Pinto, Lucas Scárdua Silva, Rafael Batista João, Vinícius Boldrini, Fernando Cendes, Clarissa Lin Yasuda
The treatment of epilepsy has advanced over the past 30 years through the development of new antiseizure medications (ASMs). Unfortunately, not all of them have been approved yet in Brazil, and many are still underused. When comparing new ASMs to older ones, they are generally not more effective in treating epilepsy. However, they offer better tolerability, with fewer interactions and long-term side effects, especially for patients with comorbidities or those requiring polytherapy. Enzyme induction caused by older ASMs is associated with increased cholesterol levels, drug interactions with decreased effects of statins and other cardiovascular medications, anticoagulants, chemotherapy, immunosuppressors, anti-infective agents (including HIV treatment), antidepressants, and contraceptives...
June 2024: Arquivos de Neuro-psiquiatria
https://read.qxmd.com/read/38531145/dhea-and-response-to-antidepressant-treatment-a-mendelian-randomization-analysis
#37
JOURNAL ARTICLE
L H Souza-Teodoro, N M Davies, H R Warren, L H S G Andrade, L A Carvalho
Treatment response is hard to predict and detailed mechanisms unknown. Lower levels of the dehydroepiandrosterone sulphate (DHEA(S)) - a precursor to testosterone and estrogen - have been associated to depression and to response to antidepressant treatment. Previous studies however may have been ridden by confounding and reverse causation. The aim of this study is to evaluate whether higher levels of DHEA(S) are causally linked to response to antidepressants using mendelian randomization (MR). We performed a Two-sample MR analysis using data the largest publicly available GWAS of DHEA(S) levels (n = 14,846) using eight common genetic variants associated to DHEA(S) (seven single nucleotide polymorphisms and one variant rs2497306) and the largest GWAS of antidepressant response (n = 5218) using various MR methods (IVW, MR Egger, Weighted mean, weighted mode, MR-PRESSO) and single SNP analysis...
February 28, 2024: Journal of Psychiatric Research
https://read.qxmd.com/read/38531038/glp-1-receptor-agonists-a-review-of-glycemic-benefits-and-beyond
#38
JOURNAL ARTICLE
LaDonna Clark
Type 2 diabetes mellitus (T2DM) is a chronic medical condition affecting millions of individuals worldwide. The burden of disease is significant, as demonstrated by high morbidity and mortality and billions of healthcare dollars spent. The pathophysiology of T2DM is complex, with eight primary deficits. In recent years, an increased focus has been placed on incretin hormones, such as glucagon-like peptide-1 (GLP-1) for its glucose-lowering benefits. Several FDA-approved short-acting and long-acting GLP-1 receptor agonists (GLP-1 RAs) are available in the United States for the treatment of T2DM...
April 1, 2024: JAAPA: Official Journal of the American Academy of Physician Assistants
https://read.qxmd.com/read/38531022/case-report-macula-structural-and-functional-assessment-in-nab-paclitaxel-related-cystoid-macular-edema
#39
JOURNAL ARTICLE
Lawrence Kwok, Alina Mahmood, Sanjeev Kumar, Andrew Chang
Nab-paclitaxel-related cystoid macular edema is a rare ophthalmic adverse drug reaction. We present a 54-year-old woman with metastatic hormone receptor positive, HER-2 negative breast carcinoma who developed profound bilateral vision loss after the seventh cycle of nab-paclitaxel treatment. Optical coherence tomography and macula microperimetry demonstrated macular edema and decreased threshold sensitivity, respectively. Cessation of nab-paclitaxel improved structural and functional vision after 4 weeks. The introduction of topical dorzolamide 1% in one eye demonstrated further rapid resolution of edema...
March 1, 2024: Ophthalmic Surgery, Lasers & Imaging Retina
https://read.qxmd.com/read/38531006/postmenopausal-endometriosis-a-challenging-condition-beyond-menopause
#40
JOURNAL ARTICLE
Alexandre Vallée, Marie Carbonnel, Pierre-François Ceccaldi, Anis Feki, Jean-Marc Ayoubi
IMPORTANCE AND OBJECTIVE: Postmenopausal endometriosis is a complex condition that challenges the conventional belief that endometriosis resolves with menopause. Despite the cessation of menstruation, a subset of women continues to experience or develop endometriosis-related symptoms during the postmenopausal period. Thus, this review aimed to shed light on postmenopausal endometriosis, exploring its clinical features, diagnostic considerations, management approaches, and the potential impact on women's health...
March 25, 2024: Menopause: the Journal of the North American Menopause Society
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