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https://www.readbyqxmd.com/read/29983616/a-proteomic-approach-reveals-the-differential-protein-expression-in-drosophila-melanogaster-treated-with-red-ginseng-extract-panax-ginseng
#1
Qing-Xiu Liu, Wei Zhang, Jia Wang, Wei Hou, Ying-Ping Wang
Background: Red ginseng is a popularly used traditional medicine with antiaging effects in Asian countries. The present study aimed to explore the changes in protein expression underlying the mechanisms of life span extension and antiaging caused by red ginseng extract (RGE) in Drosophila melanogaster . Methods: A proteomic approach of two-dimensional polyacrylamide gel electrophoresis (2-DE) was used to identify the differential abundance of possible target proteins of RGE in D...
July 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29910615/preparation-characterizations-and-anti-pollutant-activity-of-7-3-4-trihydroxyisoflavone-nanoparticles-in-particulate-matter-induced-hacat-keratinocytes
#2
Pao-Hsien Huang, Chih-Hua Tseng, Chia-Yu Lin, Chiang-Wen Lee, Feng-Lin Yen
Background: 7,3',4'-Trihydroxyisoflavone (734THI), a secondary metabolite derived from daidzein in soybean, possesses several biological activities, including antioxidant, skin whitening and anti-atopic dermatitis properties, but the poor aqueous solubility of 734THI has limited its application in medicine and cosmetic industry. Methods: The aim of the present study was to improve the physicochemical properties of 734THI using planetary ball mill preparation under a solvent-free process to improve its solubility and anti-pollutant activity...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29874836/aspirin-derivative-5-bis-3-methylbut-2-enyl-amino-2-hydroxybenzoic-acid-improves-thermotolerance-via-stress-response-proteins-in-caenorhabditis-elegans
#3
Xiao-Bing Huang, Gui-Sheng Wu, Lei-Yu Ke, Xiao-Gang Zhou, Yue-Hu Wang, Huai-Rong Luo
Aging is a major risk factor for many prevalent diseases. Pharmacological intervention to improve the health span and extend the lifespan could be a preventive elixir for aging and age-related diseases. The non-steroid anti-inflammation medicine aspirin was reported to delay aging in Caenorhabditis elegans ( C. elegans ) and mice. We are wondering if the analogues of aspirin could also present antiaging activity. Here, we synthesized several aspirin derivatives and investigated their thermotolerance and antiaging effect in C...
June 5, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29670680/gengnianchun-extends-the-lifespan-of-caenorhabditis-elegans-via-the-insulin-igf-1-signalling-pathway
#4
Fanhui Meng, Jun Li, Yanqiu Rao, Wenjun Wang, Yan Fu
Gengnianchun (GNC), a traditional Chinese medicine (TCM), is believed to have beneficial effects on ageing-related diseases, such as antioxidant properties and effects against A β -induced toxicity. We previously found that GNC extended the lifespan of Caenorhabditis elegans . However, the mechanism underlying this effect was unclear. In this study, we further explored the mechanisms of GNC using a C. elegans model. GNC significantly increased the lifespan of C. elegans and enhanced oxidative and thermal stress resistance...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29576745/anti-inflamm-ageing-and-or-anti-age-related-disease-emerging-treatments-a-historical-alchemy-or-revolutionary-effective-procedures
#5
REVIEW
Carmela Rita Balistreri
The " long-life elixir " has long represented for humans a dream, a vanity's sin for remaining young and to long survive. Today, because of ageing population phenomenon , the research of antiageing interventions appears to be more important than ever, for preserving health in old age and retarding/or delaying the onset of age-related diseases. A hope is given by experimental data, which evidence the possibility of retarding ageing in animal models. In addition, it has been also demonstrated in animal life-extending studies not only the possibility of increasing longevity but also the ability to retard the onset of age-related diseases...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29515440/resveratrol-potential-antibacterial-agent-against-foodborne-pathogens
#6
REVIEW
Dexter S L Ma, Loh Teng-Hern Tan, Kok-Gan Chan, Wei Hsum Yap, Priyia Pusparajah, Lay-Hong Chuah, Long Chiau Ming, Tahir Mehmood Khan, Learn-Han Lee, Bey-Hing Goh
Bacterial foodborne pathogens are a significant health burden and the recent emergence of pathogenic resistant strains due to the excessive use of antibiotics makes it more difficult to effectively treat infections as a result of contaminated food. Awareness of this impending health crisis has spurred the search for alternative antimicrobials with natural plant antimicrobials being among the more promising candidates as these substances have good acceptability and likely low toxicity levels as they have long been used in traditional medicines...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29509695/progress-on-the-studies-of-the-key-enzymes-of-ginsenoside-biosynthesis
#7
REVIEW
Jin-Ling Yang, Zong-Feng Hu, Ting-Ting Zhang, An-Di Gu, Ting Gong, Ping Zhu
As the main bioactive constituents of Panax species, ginsenosides possess a wide range of notable medicinal effects such as anti-cancer, anti-oxidative, antiaging, anti-inflammatory, anti-apoptotic and neuroprotective activities. However, the increasing medical demand for ginsenosides cannot be met due to the limited resource of Panax species and the low contents of ginsenosides. In recent years, biotechnological approaches have been utilized to increase the production of ginsenosides by regulating the key enzymes of ginsenoside biosynthesis, while synthetic biology strategies have been adopted to produce ginsenosides by introducing these genes into yeast...
March 6, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29363245/the-use-of-natural-ingredients-in-innovative-korean-cosmeceuticals
#8
REVIEW
Margit Lw Juhász, Melissa K Levin, Ellen S Marmur
BACKGROUND: The cosmeceutical industry is an ever-growing and in demand market, especially in Asia. Korea has been on the forefront of creating the newest generation and most innovative cosmeceuticals products including ingredients such as snail secretions, starfish powder, botanical extracts, green tea, and red ginseng. Given their increasing prevalence in the cosmeceutical industry, scientists have been conducting investigations into these extracts and their properties. OBJECTIVE: To summarize the current literature surrounding multiple natural ingredients found in Korean cosmeceutical products...
June 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29332828/uplc-ms-ms-analysis-for-antioxidant-components-of-lycii-fructus-based-on-spectrum-effect-relationship
#9
Xian-Fei Zhang, Juan Chen, Jun-Li Yang, Yan-Ping Shi
Lycii Fructus is widely cultivated in the Northwest China. It is well-known for its antiaging effect in traditional Chinese medicines (TCMs), but the effective components are not clear. In this work, the ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was used to study the antioxidant components of Lycii Fructus through analyzing the spectrum-effect relationship, and the positive correlation components with antioxidant activity were partially identified. The extractums of Lycii Fructus were adsorbed with macroporous resin, and then eluted with water and 30%, 60%, 90% ethanol in turn...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29296563/single-repeated-dose-toxicity-and-genotoxicity-assessment-of-herb-formula-kiom2012h
#10
Hwayong Park, Youn-Hwan Hwang, Jin Yeul Ma
Background: Traditional medicine and herbal prescriptions are becoming more popular, and they account for a large share of the world's healthcare research studies, developments, and market demands. Increasing scientific evidence of the substantive efficacies such as preventive health keeping pharmaceutical materials and dietary supplements can be found elsewhere. Above all, safety should be the critical premise for considering developmental materials such as pharmaceuticals without side effects and toxicity...
December 2017: Integrative Medicine Research
https://www.readbyqxmd.com/read/29279716/-fraxinus-a-plant-with-versatile-pharmacological-and-biological-activities
#11
REVIEW
Iqra Sarfraz, Azhar Rasul, Farhat Jabeen, Tahira Younis, Muhammad Kashif Zahoor, Muhammad Arshad, Muhammad Ali
Fraxinus , a member of the Oleaceae family, commonly known as ash tree is found in northeast Asia, north America, east and western France, China, northern areas of Pakistan, India, and Afghanistan. Chemical constituents of Fraxinus plant include various secoiridoids, phenylethanoids, flavonoids, coumarins, and lignans; therefore, it is considered as a plant with versatile biological and pharmacological activities. Its tremendous range of pharmacotherapeutic properties has been well documented including anticancer, anti-inflammatory, antioxidant, antimicrobial, and neuroprotective...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29246502/the-genus-polygonatum-a-review-of-ethnopharmacology-phytochemistry-and-pharmacology
#12
REVIEW
Ping Zhao, Chengcheng Zhao, Xia Li, Qingzhi Gao, Luqi Huang, Peigen Xiao, Wenyuan Gao
ETHNOPHARMACOLOGICAL RELEVANCE: The genus Polygonatum (Asparagaceae) comprises 71 species distributed throughout the temperate Northern Hemisphere. The medicinal plants of Polygonatum have been traditionally used as tonics in China, India, Pakistan, Iran and Japan, and have been demonstrated to be highly effective in clinical practice for treating age-related diseases, diabetes, lung diseases, fatigue, feebleness and indigestion. AIM OF THE REVIEW: This paper aims to provide the links among traditional uses, chemical constituents, pharmacological effects and toxicity to support their therapeutic potential and uncover opportunities for future research...
March 25, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29227203/therapeutic-charm-of-quercetin-and-its-derivatives-a-review-of-research-and-patents
#13
Ajay Sharma, Dharambir Kashyap, Katrin Sak, Hardeep Singh Tuli, Anil K Sharma
Bioactive polyphenolic compounds derived from plants are being utilized for prevention of various chronic diseases including cancer and cardiovascular disorders. Quercetin, a potential poly-phenolic flavonol, found in onions, apples and berries, has been implicated against cancer proliferation, chronic inflammation and various other oxidative manifestations. Evidences suggested that quercetin negatively regulates the numerous crucial signaling pathways associated with life-threatening diseases. Major signaling pathways including NF-κB, MAPK, PI3K-AKT and mTOR are found to be regulated by quercetin...
January 2018: Pharmaceutical Patent Analyst
https://www.readbyqxmd.com/read/29188771/hplc-and-gc-ms-identification-and-quantification-of-strychnine-and-brucine-in-strychnos-nux-vomica-leaves
#14
P N Prasad Maddisetty, V A Doss, Mohanasundaram S, Srinivasarao V, Mohanbabu T
In this study, we have aimed to analyze the phytochemical composition of this plant and the concentration of strychnine and brucine. The identification of bioactive compounds was done by GC-MS with NIST Library. Strychnine and Brucine were quantified using HPLC. Twenty one medicinal bio active compounds were identified from the Strychnos nux-vomica leaf ethanolic extract. Strychnine is showing 28.43% purity and brucine was not detected in GCMS analysis. Quantified the concentration of strychnine (0.6 mg in 500mg of extract) and brucine (1...
November 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29155174/ethnopharmacology-phytochemistry-and-pharmacology-of-cornus-officinalis-sieb-et-zucc
#15
REVIEW
Jun Huang, Yiwei Zhang, Lin Dong, Qinghan Gao, Lei Yin, Hongfeng Quan, Rong Chen, Xueyan Fu, Dingbo Lin
ETHNOPHARMACOLOGICAL RELEVANCE: Cornus officinalis (Cornaceae), known in Chinese as "Shanzhuyu," is a frequently used traditional Chinese medicine. It tastes sour and is astringent and slightly warm in nature. Its fruits have long been used to treat kidney deficiency, high blood pressure, waist and knee pain, dizziness, tinnitus, impotence, spermatorrhea, menorrhagia, and other diseases in China. The main distribution areas are Shanxi and Gansu. AIM OF THE STUDY: This review focused on the ethnopharmacological uses of the herb...
March 1, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29064988/signs-of-facial-aging-in-men-in-a-diverse-multinational-study-timing-and-preventive-behaviors
#16
MULTICENTER STUDY
Anthony M Rossi, Joseph Eviatar, Jeremy B Green, Robert Anolik, Michael Eidelman, Terrence C Keaney, Vic Narurkar, Derek Jones, Julia Kolodziejczyk, Adrienne Drinkwater, Conor J Gallagher
BACKGROUND: Men are a growing patient population in aesthetic medicine and are increasingly seeking minimally invasive cosmetic procedures. OBJECTIVE: To examine differences in the timing of facial aging and in the prevalence of preventive facial aging behaviors in men by race/ethnicity. METHODS: Men aged 18 to 75 years in the United States, Canada, United Kingdom, and Australia rated their features using photonumeric rating scales for 10 facial aging characteristics...
November 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28751929/the-preconditioning-of-berberine-suppresses-hydrogen-peroxide-induced-premature-senescence-via-regulation-of-sirtuin-1
#17
Xiaofei Zhu, Haodi Yue, Xiaofang Guo, Jingyi Yang, Jingshuo Liu, Jiangtao Liu, Ruijie Wang, Wenjuan Zhu
With a long history of application in Chinese traditional medicine, berberine (BBR) was reported to exhibit healthspan-extending properties in some age-related diseases, such as type 2 diabetes and atherosclerosis. However, the antiaging mechanism of BBR is not completely clear. By means of hydrogen peroxide- (H2 O2 -) induced premature cellular senescence model, we found that a low-concentration preconditioning of BBR could resist premature senescence in human diploid fibroblasts (HDFs) measured by senescence-associated β -galactosidase (SA- β -gal), accompanied by a decrease in loss of mitochondrial membrane potential and production of intracellular reactive oxygen species (ROS)...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28458714/antiaging-and-anxiolytic-effects-of-combinatory-formulas-based-on-four-medicinal-herbs
#18
Rui Li, Wingman Chan, Waikin Mat, Yiucheong Ho, Rigil K Yeung, Shuiying Tsang, Hong Xue
The objective of the present study was to search for medicinal-herb combinations based on Radix Bupleurum chinense DC ("B"), Rhizoma Corydalis yanhusuo WT Wang ("Y"), Caulis Polygonum multiflorum Thunb ("P"), and Flos Albizia julibrissin Durazz ("A") for antiaging, anxiolytic, and sedative effects. Application of the D-galactose induced accelerated-aging model employing male ICR mice showed that oral administration of some combinations of B, Y, P, and A significantly improved spatial memory in Y-maze test and reduced brain levels of tumor necrosis factor-α and interleukin-6 based on immunoassays and oxidative stress marker malondialdehyde, based on the thiobarbituric acid test, and the loss of whiskers, indicating antiaging and antineurodegeneration effects...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28268173/improvement-of-osteoporosis-by-lycium-chinense-administration-in-ovariectomized-mice
#19
Mi Hye Kim, Ji Eun Lee, Jae Sung Lee, Woong Mo Yang
BACKGROUND: The fruit of Lycium chinense (LC), one of the most popular natural materials, has been used to counter the effects of musculoskeletal diseases in oriental medicine. In particular, this fruit is known to have antiaging effects, which is of significant interest to the research community. The purpose of our investigation was to observe and confirm the ameliorative effect of LC on osteoporosis, which was verified in this in vivo study. METHODS: Female ICR mice aged 5 weeks were surgically ovariectomized (OVX) to induce osteoporosis...
April 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28123324/antiaging-effects-of-the-mixture-of-panax-ginseng-and-crataegus-pinnatifida-in-human-dermal-fibroblasts-and-healthy-human-skin
#20
Eunson Hwang, Sang-Yong Park, Chang Shik Yin, Hee-Taek Kim, Yong Min Kim, Tae Hoo Yi
BACKGROUND: Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to upregulation of matrix metalloproteinase-1, which then causes collagen degradation and premature aging. Mixtures of medicinal plants have traditionally been used as drugs in oriental medicine. Based on the previously reported antioxidant properties of Panax ginseng Meyer and Crataegus pinnatifida, we hypothesized that the mixture of P...
January 2017: Journal of Ginseng Research
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