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Antiaging medicine

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https://www.readbyqxmd.com/read/30301204/aqueous-extract-of-davallia-mariesii-attenuates-6-hydroxydopamine-induced-oxidative-damage-and-apoptosis-in-b35-cells-through-inhibition-of-caspase-cascade-and-activation-of-pi3k-akt-gsk-3%C3%AE-pathway
#1
Chi-Rei Wu, Hung-Chi Chang, Yih-Dih Cheng, Wan-Cheng Lan, Shu-Er Yang, Hui Ching
The medicinal ferns of Polydiaceae and Davalliaceae species are called "Gusuibu" by Chinese physicians and used as antiaging dietary medicines. Our previous report revealed that Drynaria fortunei (Polydiaceae) protected against 6-hydroxydopamine (6-OHDA)-induced oxidative damage via the PI3K/AKT pathway in B35 neuroblastoma cells. The present study compares the antioxidant phytoconstituent contents and radical scavenging capacities of five Davalliaceae species. The further aim was to clarify the protective mechanism of Davallia mariesii (DM) against 6-OHDA-induced oxidative damage and apoptosis in B35 cells...
October 6, 2018: Nutrients
https://www.readbyqxmd.com/read/30268653/genus-vanda-a-review-on-traditional-uses-bioactive-chemical-constituents-and-pharmacological-activities
#2
REVIEW
Haroon Khan, Marya, Tarun Belwal, Mohd Tariq, Atanas G Atanasov, Hari Prasad Devkota
ETHNOPHARMACOLOGICAL RELEVANCE: The genus Vanda (Family: Orchidaceae) comprises about 73 species mainly distributed in Southeast Asia. Plants belonging to this genus are being used in the traditional medicine systems in Asian countries specially in India, Nepal, China and Bangladesh. AIM OF THE REVIEW: The aim of this work was to review the scientific work about medicinal orchids of the genus Vanda regarding their traditional uses, reported bioactive components, and pharmacological activities...
September 27, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/30232757/microbiota-and-aging
#3
Maoyang Lu, Zhao Wang
The human gut microbiota is a huge ecosystem that provides lots of functions for host development, immune system, and metabolism. Gut microbiota is linked to lots of diseases, including human metabolic diseases such as obesity, type 2 diabetes (T2D), irritable bowel syndrome, and cardiovascular disease (CVD). Few studies, however, have noted the relationship between aging and microbiota; the connection between aging and microbiota remains largely to be researched. In this review, recent research findings are summarized on the role of gut microbiota in aging processes with emphasis on therapeutic potential of microbiome-targeted interventions in antiaging medicine...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30232755/aging-of-human-adult-stem-cells
#4
Han Xie, Shouliang Zhao, Shangfeng Liu
With the continuous development of stem cell research in recent years, it is realized that stem cell aging may be the core issue of organ aging. As an important approach and main content of regenerative medicine, the stem cell research brings great hope to overcome difficult diseases and improve the quality of life for human beings and become the key to solve this issue. Based on this research, the varying characteristics of stem cells in aging could be recognized; the role of stem cells in the organ aging and regeneration will be revealed; the function of stem cells will be controllable and regulatable in tissues and organs; the stem cells from tissues and organs with rapid or slow cell renewal (e...
2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/30114634/ganoderma-lucidum-persuasive-biologically-active-constituents-and-their-health-endorsement
#5
REVIEW
Md Faruque Ahmad
Ganoderma lucidum comprises probably 400 different biologically active constituents principally polysaccharides, triterpenoids, proteins, enzymes, steroids, sterols, nucleotides, fatty acids, vitamins and minerals which have been proved to have several therapeutical properties to control various diseases. Broad spectrum of its pharmacological actions have been established which include immunomodulation, anticancer, antidiabetic, antioxidant, antiatherosclerotic, antifibrotic, chemopreventive, antitumor, anticancer drug toxicity prevention, analgesic, anti inflammatory, antinociceptive, antimicrobial, hypolipidemic, hepatoprotective, antiandrogenic, antiangiogenic, antiherpetic, antiarthritic, antiosteoporotic, antiaging, antiulcer properties and estrogenic activity...
November 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29983616/a-proteomic-approach-reveals-the-differential-protein-expression-in-drosophila-melanogaster-treated-with-red-ginseng-extract-panax-ginseng
#6
Qing-Xiu Liu, Wei Zhang, Jia Wang, Wei Hou, Ying-Ping Wang
Background: Red ginseng is a popularly used traditional medicine with antiaging effects in Asian countries. The present study aimed to explore the changes in protein expression underlying the mechanisms of life span extension and antiaging caused by red ginseng extract (RGE) in Drosophila melanogaster . Methods: A proteomic approach of two-dimensional polyacrylamide gel electrophoresis (2-DE) was used to identify the differential abundance of possible target proteins of RGE in D...
July 2018: Journal of Ginseng Research
https://www.readbyqxmd.com/read/29910615/preparation-characterizations-and-anti-pollutant-activity-of-7-3-4-trihydroxyisoflavone-nanoparticles-in-particulate-matter-induced-hacat-keratinocytes
#7
Pao-Hsien Huang, Chih-Hua Tseng, Chia-Yu Lin, Chiang-Wen Lee, Feng-Lin Yen
Background: 7,3',4'-Trihydroxyisoflavone (734THI), a secondary metabolite derived from daidzein in soybean, possesses several biological activities, including antioxidant, skin whitening and anti-atopic dermatitis properties, but the poor aqueous solubility of 734THI has limited its application in medicine and cosmetic industry. Methods: The aim of the present study was to improve the physicochemical properties of 734THI using planetary ball mill preparation under a solvent-free process to improve its solubility and anti-pollutant activity...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29874836/aspirin-derivative-5-bis-3-methylbut-2-enyl-amino-2-hydroxybenzoic-acid-improves-thermotolerance-via-stress-response-proteins-in-caenorhabditis-elegans
#8
Xiao-Bing Huang, Gui-Sheng Wu, Lei-Yu Ke, Xiao-Gang Zhou, Yue-Hu Wang, Huai-Rong Luo
Aging is a major risk factor for many prevalent diseases. Pharmacological intervention to improve the health span and extend the lifespan could be a preventive elixir for aging and age-related diseases. The non-steroid anti-inflammation medicine aspirin was reported to delay aging in Caenorhabditis elegans ( C. elegans ) and mice. We are wondering if the analogues of aspirin could also present antiaging activity. Here, we synthesized several aspirin derivatives and investigated their thermotolerance and antiaging effect in C...
June 5, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29670680/gengnianchun-extends-the-lifespan-of-caenorhabditis-elegans-via-the-insulin-igf-1-signalling-pathway
#9
Fanhui Meng, Jun Li, Yanqiu Rao, Wenjun Wang, Yan Fu
Gengnianchun (GNC), a traditional Chinese medicine (TCM), is believed to have beneficial effects on ageing-related diseases, such as antioxidant properties and effects against A β -induced toxicity. We previously found that GNC extended the lifespan of Caenorhabditis elegans . However, the mechanism underlying this effect was unclear. In this study, we further explored the mechanisms of GNC using a C. elegans model. GNC significantly increased the lifespan of C. elegans and enhanced oxidative and thermal stress resistance...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29576745/anti-inflamm-ageing-and-or-anti-age-related-disease-emerging-treatments-a-historical-alchemy-or-revolutionary-effective-procedures
#10
REVIEW
Carmela Rita Balistreri
The " long-life elixir " has long represented for humans a dream, a vanity's sin for remaining young and to long survive. Today, because of ageing population phenomenon , the research of antiageing interventions appears to be more important than ever, for preserving health in old age and retarding/or delaying the onset of age-related diseases. A hope is given by experimental data, which evidence the possibility of retarding ageing in animal models. In addition, it has been also demonstrated in animal life-extending studies not only the possibility of increasing longevity but also the ability to retard the onset of age-related diseases...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29515440/resveratrol-potential-antibacterial-agent-against-foodborne-pathogens
#11
REVIEW
Dexter S L Ma, Loh Teng-Hern Tan, Kok-Gan Chan, Wei Hsum Yap, Priyia Pusparajah, Lay-Hong Chuah, Long Chiau Ming, Tahir Mehmood Khan, Learn-Han Lee, Bey-Hing Goh
Bacterial foodborne pathogens are a significant health burden and the recent emergence of pathogenic resistant strains due to the excessive use of antibiotics makes it more difficult to effectively treat infections as a result of contaminated food. Awareness of this impending health crisis has spurred the search for alternative antimicrobials with natural plant antimicrobials being among the more promising candidates as these substances have good acceptability and likely low toxicity levels as they have long been used in traditional medicines...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29509695/progress-on-the-studies-of-the-key-enzymes-of-ginsenoside-biosynthesis
#12
REVIEW
Jin-Ling Yang, Zong-Feng Hu, Ting-Ting Zhang, An-Di Gu, Ting Gong, Ping Zhu
As the main bioactive constituents of Panax species, ginsenosides possess a wide range of notable medicinal effects such as anti-cancer, anti-oxidative, antiaging, anti-inflammatory, anti-apoptotic and neuroprotective activities. However, the increasing medical demand for ginsenosides cannot be met due to the limited resource of Panax species and the low contents of ginsenosides. In recent years, biotechnological approaches have been utilized to increase the production of ginsenosides by regulating the key enzymes of ginsenoside biosynthesis, while synthetic biology strategies have been adopted to produce ginsenosides by introducing these genes into yeast...
March 6, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29363245/the-use-of-natural-ingredients-in-innovative-korean-cosmeceuticals
#13
REVIEW
Margit Lw Juhász, Melissa K Levin, Ellen S Marmur
BACKGROUND: The cosmeceutical industry is an ever-growing and in demand market, especially in Asia. Korea has been on the forefront of creating the newest generation and most innovative cosmeceuticals products including ingredients such as snail secretions, starfish powder, botanical extracts, green tea, and red ginseng. Given their increasing prevalence in the cosmeceutical industry, scientists have been conducting investigations into these extracts and their properties. OBJECTIVE: To summarize the current literature surrounding multiple natural ingredients found in Korean cosmeceutical products...
June 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29332828/uplc-ms-ms-analysis-for-antioxidant-components-of-lycii-fructus-based-on-spectrum-effect-relationship
#14
Xian-Fei Zhang, Juan Chen, Jun-Li Yang, Yan-Ping Shi
Lycii Fructus is widely cultivated in the Northwest China. It is well-known for its antiaging effect in traditional Chinese medicines (TCMs), but the effective components are not clear. In this work, the ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was used to study the antioxidant components of Lycii Fructus through analyzing the spectrum-effect relationship, and the positive correlation components with antioxidant activity were partially identified. The extractums of Lycii Fructus were adsorbed with macroporous resin, and then eluted with water and 30%, 60%, 90% ethanol in turn...
April 1, 2018: Talanta
https://www.readbyqxmd.com/read/29296563/single-repeated-dose-toxicity-and-genotoxicity-assessment-of-herb-formula-kiom2012h
#15
Hwayong Park, Youn-Hwan Hwang, Jin Yeul Ma
Background: Traditional medicine and herbal prescriptions are becoming more popular, and they account for a large share of the world's healthcare research studies, developments, and market demands. Increasing scientific evidence of the substantive efficacies such as preventive health keeping pharmaceutical materials and dietary supplements can be found elsewhere. Above all, safety should be the critical premise for considering developmental materials such as pharmaceuticals without side effects and toxicity...
December 2017: Integrative Medicine Research
https://www.readbyqxmd.com/read/29279716/-fraxinus-a-plant-with-versatile-pharmacological-and-biological-activities
#16
REVIEW
Iqra Sarfraz, Azhar Rasul, Farhat Jabeen, Tahira Younis, Muhammad Kashif Zahoor, Muhammad Arshad, Muhammad Ali
Fraxinus , a member of the Oleaceae family, commonly known as ash tree is found in northeast Asia, north America, east and western France, China, northern areas of Pakistan, India, and Afghanistan. Chemical constituents of Fraxinus plant include various secoiridoids, phenylethanoids, flavonoids, coumarins, and lignans; therefore, it is considered as a plant with versatile biological and pharmacological activities. Its tremendous range of pharmacotherapeutic properties has been well documented including anticancer, anti-inflammatory, antioxidant, antimicrobial, and neuroprotective...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29246502/the-genus-polygonatum-a-review-of-ethnopharmacology-phytochemistry-and-pharmacology
#17
REVIEW
Ping Zhao, Chengcheng Zhao, Xia Li, Qingzhi Gao, Luqi Huang, Peigen Xiao, Wenyuan Gao
ETHNOPHARMACOLOGICAL RELEVANCE: The genus Polygonatum (Asparagaceae) comprises 71 species distributed throughout the temperate Northern Hemisphere. The medicinal plants of Polygonatum have been traditionally used as tonics in China, India, Pakistan, Iran and Japan, and have been demonstrated to be highly effective in clinical practice for treating age-related diseases, diabetes, lung diseases, fatigue, feebleness and indigestion. AIM OF THE REVIEW: This paper aims to provide the links among traditional uses, chemical constituents, pharmacological effects and toxicity to support their therapeutic potential and uncover opportunities for future research...
March 25, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29227203/therapeutic-charm-of-quercetin-and-its-derivatives-a-review-of-research-and-patents
#18
Ajay Sharma, Dharambir Kashyap, Katrin Sak, Hardeep Singh Tuli, Anil K Sharma
Bioactive polyphenolic compounds derived from plants are being utilized for prevention of various chronic diseases including cancer and cardiovascular disorders. Quercetin, a potential poly-phenolic flavonol, found in onions, apples and berries, has been implicated against cancer proliferation, chronic inflammation and various other oxidative manifestations. Evidences suggested that quercetin negatively regulates the numerous crucial signaling pathways associated with life-threatening diseases. Major signaling pathways including NF-κB, MAPK, PI3K-AKT and mTOR are found to be regulated by quercetin...
January 2018: Pharmaceutical Patent Analyst
https://www.readbyqxmd.com/read/29188771/hplc-and-gc-ms-identification-and-quantification-of-strychnine-and-brucine-in-strychnos-nux-vomica-leaves
#19
P N Prasad Maddisetty, V A Doss, Mohanasundaram S, Srinivasarao V, Mohanbabu T
In this study, we have aimed to analyze the phytochemical composition of this plant and the concentration of strychnine and brucine. The identification of bioactive compounds was done by GC-MS with NIST Library. Strychnine and Brucine were quantified using HPLC. Twenty one medicinal bio active compounds were identified from the Strychnos nux-vomica leaf ethanolic extract. Strychnine is showing 28.43% purity and brucine was not detected in GCMS analysis. Quantified the concentration of strychnine (0.6 mg in 500mg of extract) and brucine (1...
November 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29155174/ethnopharmacology-phytochemistry-and-pharmacology-of-cornus-officinalis-sieb-et-zucc
#20
REVIEW
Jun Huang, Yiwei Zhang, Lin Dong, Qinghan Gao, Lei Yin, Hongfeng Quan, Rong Chen, Xueyan Fu, Dingbo Lin
ETHNOPHARMACOLOGICAL RELEVANCE: Cornus officinalis (Cornaceae), known in Chinese as "Shanzhuyu," is a frequently used traditional Chinese medicine. It tastes sour and is astringent and slightly warm in nature. Its fruits have long been used to treat kidney deficiency, high blood pressure, waist and knee pain, dizziness, tinnitus, impotence, spermatorrhea, menorrhagia, and other diseases in China. The main distribution areas are Shanxi and Gansu. AIM OF THE STUDY: This review focused on the ethnopharmacological uses of the herb...
March 1, 2018: Journal of Ethnopharmacology
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