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carcinoma of bladder

Yu I Osmanov, Zh A Gaibov, E A Kogan, S G Radenska-Lopovok, Kh Z Tursunov
Urothelial carcinoma is one of the most frequently diagnosed malignant tumors of the bladder and upper urinary tract, which ranks seventh in the pattern of cancer. Urothelial carcinoma of the renal pelvis is less common; but has a more aggressive clinical course and a worse prognosis than that of the bladder. This is due to the clinical and morphological features of this form of cancer, which, unlike bladder cancer, have not been studied enough. OBJECTIVE: To comparatively analyze the morphological and immunophenotypic parameters of urothelial carcinomas of the renal pelvis and bladder...
2018: Arkhiv Patologii
Iwona Belczacka, Martin Pejchinovski, Magdalena Krochmal, Pedro Magalhães, Maria Frantzi, William Mullen, Antonia Vlahou, Harald Mischak, Vera Jankowski
PURPOSE: Urine is a rich source of potential biomarkers, including glycoproteins. Glycoproteomic analysis remains difficult due to the high heterogeneity of glycans. Nevertheless, recent advances in glycoproteomics software solutions facilitate glycopeptide identification and characterization. The aim is to investigate intact glycopeptides in the urinary peptide profiles of normal subjects using a novel PTM-centric software-Byonic. EXPERIMENTAL DESIGN: The urinary peptide profiles of 238 normal subjects, previously analyzed using CE-MS and CE-MS/MS and/or LC-MS/MS, are subjected to glycopeptide analysis...
October 18, 2018: Proteomics. Clinical Applications
Jian-Ri Li, Kun-Yuan Chiu, Yen-Chuan Ou, Shian-Shiang Wang, Chuan-Su Chen, Cheng-Kuang Yang, Hao-Chung Ho, Chen-Li Cheng, Chi-Rei Yang, Cheng-Che Chen, Shu-Chi Wang, Chia-Yen Lin, Sheng-Chun Hung, Chiann-Yi Hsu, Chun-Jung Chen
Fibroblast growth factors (FGF) 19, 21, and 23 have been reported as functional factors in human metabolic diseases and malignancies. We performed a prospective survey to compare circulating FGF levels in urothelial carcinoma (UC) patients and normal controls. Between 2016 and 2017, 39 patients with UC of the urinary bladder or upper urinary tract who received surgical intervention were included. All the serum samples were obtained before surgeries. The control group included 28 healthy volunteers. Analysis of the circulating FGF19, 21, and 23 levels among all 67 subjects, as well as a subgroup analysis of the 39 UC patients were performed...
October 17, 2018: BioFactors
Arjanneke F van de Merbel, Geertje van der Horst, Maaike H van der Mark, Janneke I M van Uhm, Erik J van Gennep, Peter Kloen, Lijkele Beimers, Rob C M Pelger, Gabri van der Pluijm
Urological malignancies, including prostate and bladder carcinoma, represent a major clinical problem due to the frequent occurrence of therapy resistance and the formation of incurable distant metastases. As a result, there is an urgent need for versatile and predictive disease models for the assessment of the individualized drug response in urological malignancies. Compound testing on ex vivo cultured patient-derived tumor tissues could represent a promising approach. In this study, we have optimized an ex vivo culture system of explanted human prostate and bladder tumors derived from clinical specimens and human cancer cell lines xenografted in mice...
2018: Frontiers in Oncology
Bo Cai, Limin Ma, Shaojun Nong, You Wu, Xin Guo, Jinxian Pu
Human bladder cancer is one of the most aggressive tumours known and has shown resistance to traditional chemotherapy, which depends heavily on DNA-damaging drugs. β-elemene is one of the least cytotoxic antitumor agents that are extracted from Curcuma aromatica salisb and it exhibits antitumor effects in many carcinomas. β-elemene has attracted the attention of clinicians and scientists worldwide due to its few side effects and limited effect on the bone marrow. However, the antitumor mechanism of β-elemene remains largely unstudied...
November 2018: Oncology Letters
Hikmat Permana, Guntur Darmawan, Ervita Ritonga, Maya Kusumawati, Miftahurachman Miftahurachman, Nanny Natalia Soetedjo
Adrenocortical carcinoma (ACC) is a rare solid tumor with an incidence of 0.5 to 2 cases per million per year. It affects women more commonly than men with a ratio of 1.5:1. Ectopic ACC are considered to be extremely rare with no exact incidence data yet. We report an interesting case of hepatic ACC in a young woman with clinical signs of virilization.A-21-year old Sundanese woman visited our endocrine clinic with progressive hirsutism over the face, body, and extremities starting 14 years previously. She had irregular, heavy periods when she was 7 years old...
July 2018: Acta Medica Indonesiana
Akira Ooki, Christopher J VandenBussche, Max Kates, Noah M Hahn, Andres Matoso, David J McConkey, Trinity J Bivalacqua, Mohammad Obaidul Hoque
BACKGROUND: CD24 is a cornerstone of tumour progression in urothelial carcinoma of the bladder (UCB). However, its contribution to cancer stem cell (CSC)-like traits and the clinical utility of CD24 as a urinary biomarker for cancer detection have not been determined. METHODS: The functional relevance of CD24 was evaluated using in vitro and in vivo approaches. The clinical utility of CSC-related molecules was assessed in urine samples by quantitative RT-PCR. RESULTS: The knockdown of CD24 attenuated cancer stemness properties...
October 17, 2018: British Journal of Cancer
Austin Lunney, Allan Haynes, Pranav Sharma
PURPOSE: Non - muscle - invasive bladder cancer (NMIBC) can recur despite transurethral resection (TURBT) and adjuvant intravesical therapy. Tobacco products excreted in the urine are hypothesized to cause tumor - promoting effects on urothelial cells through direct contact. We determined if moderate or severe lower urinary tract symptoms (LUTS) (defined as International Prostate Symptom Score [IPSS] ≥ 8) was associated with increased tumor recurrence. MATERIALS AND METHODS: We retrospectively identified 70 consecutive men initially diagnosed with NMIBC at our institution from 2010 - 2016...
September 20, 2018: International Braz J Urol: Official Journal of the Brazilian Society of Urology
Joachim Mathes, Steffen Rausch, Tilman Todenhöfer, Arnulf Stenzl
Radical cystectomy is the standard therapy for patients with muscle-invasive bladder cancer. Organ-preserving surgical procedures have been established as alternatives to radical surgery for localized malignancies in other anatomic sites. Trimodal therapy consisting of radiation therapy, chemotherapy, and either transurethral resection of the bladder or partial cystectomy is an effective treatment for selected patients with muscle-invasive bladder cancer that allows for preservation of the urinary bladder. Areas covered: This review provides an overview of the value of trimodal therapy in the treatment of muscle-invasive bladder cancer...
October 16, 2018: Expert Review of Anticancer Therapy
Hongfei Sun, Tao Lin, Kai Xie, Liugang Gao, Jianfeng Sui, Xinye Ni
The purpose of this study is to create a new pseudo-computed tomography (CT) imaging approach under superposed ultrasound (US) deformation fields based on step-by-step local registration. Scanned CT and US 3D image datasets of three patients with postoperative cervical carcinoma were selected, including CT (CTsim) and US images (USsim) acquired during simulated positioning process and cone beam CT (CBCT) and US images for positioning verification (USpv) acquired after treatment for 10 times. Regions of interest such as urinary bladders were segmented out and accepted local registration to obtain different deformation fields...
October 15, 2018: Medical & Biological Engineering & Computing
Karmel Webb, Pradhib Venkatesan
Introduction: Guillain Barré Syndrome (GBS) has rarely been associated with tuberculosis and has been previously reported after Bacille Calmette Guérin (BCG) vaccination, but we report an association of GBS with intra-vesical BCG instillations followed by the clinical picture of disseminated BCGosis. Case presentation: A 68-year-old man with bladder carcinoma had a transurethral tumour resection followed by repeated BCG instillations. Catheterization for his eighth dose was traumatic, causing frank haematuria...
August 2018: JMM Case Reports
Koichi Uemura, Takashi Kawahara, Hiroaki Ishida, Noboru Nakaigawa, Mikiko Tanabe, Masahiro Yao, Hiroji Uemura
A 59-year-old man was referred to our hospital complaining of asymptomatic gross hematuria. Cystoscopy revealed a papillary tumor 8 cm in diameter filling the bladder. The patient underwent transurethral resection of the bladder tumor. The pathological findings revealed the sarcomatoid variant of urothelial carcinoma with a heterologous osteosarcomatous element. He had no metastasis according to our imaging analyses; thus, we planned radical cystectomy after two courses of neoadjuvant chemotherapy (gemcitabine and cisplatin)...
September 2018: Case Reports in Oncology
Sung Han Kim, Mi Kyung Song, Jung Kwon Kim, Bumsik Hong, Seok Ho Kang, Ja Hyeon Ku, Byong Chang Jeong, Ho Kyung Seo
Purpose: To compare oncologic outcomes between open nephroureterectomy (ONU) and laparoscopic nephroureterectomy (LNU) in patients with upper tract urothelial carcinoma. Materials and Methods: The medical records of consecutive ONU and LNU cases from five tertiary institutions were retrospectively analyzed between 2000 and 2012. The propensity-score matching methodology was used to compare the two surgical approaches in terms of age, body mass index, American Society of Anesthesiologists score, tumor location, grade, pathologic T and N stages, the presence of lymphovascular invasion, and follow-up duration...
October 12, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Wenchao Xu, Fulian Chen, Xiao Fei, Xiaoqing Yang, Xiaofei Lu
BACKGROUND SET and MYND domain-containing protein 2 (SMYD2), which is identified as a protein-lysine methyltransferase, plays a crucial role in the progression of some tumors such as bladder carcinoma. However, the clinical significance of SMYD2 in patients with papillary thyroid carcinoma (PTC) has not been elucidated. In the present study, we aimed to investigate the expression and role of SMYD2 in human PTC. MATERIAL AND METHODS Clinicopathological analysis was performed in 107 patients with PTC. Expression of SMYD2 was determined by immunohistochemistry staining, quantitative RT-PCR, or Western blotting in PTC tissues, adjacent normal tissues, and PTC cells (K1 and B-CPAP)...
October 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
M Rouprêt, E Xylinas, P Colin, N Houédé, E Compérat, F Audenet, S Larré, A Masson-Lecomte, G Pignot, S Brunelle, M Roumiguié, Y Neuzillet, A Méjean
INTRODUCTION: To propose an update of the French guidelines from the national committee ccAFU on upper tract urothelial carcinomas (UTUC). METHODS: A systematic Medline search was performed between 2016 and 2018, with regards to the diagnosis, the options of treatment and the follow-up of UTUC, to evaluate the different studies with levels of evidence. RESULTS: The diagnosis of this rare disease is based on CT-scan acquisition during excretion and ureteroscopy with histological biopsies...
October 11, 2018: Progrès en Urologie
Jian-Guo Qiu, Da-Yan Shi, Xin Liu, Xi-Xia Zheng, Lei Wang, Qian Li
Urothelial bladder carcinoma is the ninth most common cancer in the world, with an estimated 150,000 deaths per year. Two comprehensive analysis based on The Cancer Genome Atlas urothelial bladder carcinoma reported that chromatin modifier gene mutations were common in bladder cancer. We aimed to find how the mutations and transcriptional profiles of the genes involving in chromatin modification affected the prognosis of patients. The data were retrieved from the Genomic Data Commons data portal and the gene list in pathway Chromatin Modifying Enzymes were obtained from Reactome...
October 14, 2018: Journal of Cellular Physiology
T Martin, K Mantey, R Boissier, P Albert, V Grisoni, E Lechevallier, D Barriol, G Gravis, G Pignot, D Rossi, J Lorca, C Rattier, C Eghazarian, N Daou, J L Davin, C Clément, A Akiki, L Pascal, G Karsenty
INTRODUCTION: The REVELA13 observatory is a unique epidemiological tool listing the new cases of kidney tumors, bladder tumors and acute leukaemias in the Bouches-du-Rhône county (France). Aim was to exploit for the first time data from this observatory regarding new cases of bladder tumors≥T1 in women from 2012 to 2014. MATERIALS: This epidemiological study was observational and descriptive. Fifteen non-nominative variables from the REVELA13 database were analyzed in order to describe the clinical and pathological characteristics of the incident cases as well as their spatial and temporal distribution...
October 10, 2018: Progrès en Urologie
Putu Angga Risky Raharja, Agus Rizal A H Hamid, Chaidir A Mochtar, Rainy Umbas
White-light cystoscopy (WLC) is the diagnostic standard for the detection of bladder cancer (BC). However, the detection of small papillary and subtle flat carcinoma in situ lesions is not always possible with WLC. Several adjunctive optical imaging technologies have been developed to improve BC detection and resection. Photodynamic diagnosis, which requires the administering of a photoactive substance, has a higher detection rate than WLC for the detection of BC. Narrow-band imaging provides better visualization of tumors by contrast enhancement between normal mucosa and well-vascularized lesions...
October 10, 2018: Photodiagnosis and Photodynamic Therapy
Ping Wu, Xiaofeng Meng, Huade Zheng, Qin Zeng, Tianfeng Chen, Wen Wang, Xia Zhang, Jianyu Su
Bladder cancer has become the most common malignant urinary carcinoma. Studies have shown that significant antioxidant and bladder cancer-fighting properties of several plant-based diets like Psidium guajava , ginger and amomum, are associated with their high kaempferol content. In this paper, we evaluated the antioxidant and anticancer activities of kaempferol and its mechanism of induction to apoptosis on bladder cancer cells. Our findings demonstrated that kaempferol showed an obvious radical scavenging activity in erythrocytes damaged by oxygen...
October 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Xin Chen, Rixin Chen, Wen-Su Wei, Yonghong Li, Zi-Hao Feng, Lei Tan, Jie-Wei Chen, Gangjun Yuan, Siliang Chen, Shen-Jie Guo, Kanghua Xiao, Zhuo-Wei Liu, Jun Hang Luo, Fang-Jian Zhou, Dan Xie
PURPOSE: Circular RNAs (circRNAs), a novel class of non-coding RNAs, have recently been drawn lots of attention in the pathogenesis of human cancers. However, the role of circRNAs in cancer cells epithelial-mesenchymal transition (EMT) remains unclear. In this study, we aimed to identify novel circRNAs that regulates urothelial carcinoma of the bladder (UCB) cells EMT and explored their regulatory mechanisms and clinical significance in UCBs. EXPERIMENTAL DESIGN: We first screened circRNA expression profiles using a circRNA microarray in paired UCB and normal tissues, and then studied the clinical significance of an up-regulated circRNA, circPRMT5, in a large cohort of UCB patients...
October 10, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
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