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Randolph Stone Ii, John T Wall, Shanmugasundaram Natesan, Robert J Christy
In vitro cell culture methods are used extensively to study cellular migration, proliferation, and differentiation, which play major roles in wound healing but the results often do not translate to the in vivo environment. One alternative would be to establish an ex vivo model utilizing human discarded skin to evaluate therapies in a more natural setting. The purpose of this study was to institute such a model by creating 'wounds' in the center of a piece of discarded skin and treating them with three different biomaterials: collagen, polyethylene glycol (PEG)-fibrin, or PEG-platelet free plasma (PFP)...
October 13, 2018: International Journal of Molecular Sciences
Tatsiana G Shutava, Kanstantsin S Livanovich, Anastasiya A Sharamet
Layer-by-layer (LbL) films with enhanced resistance to protein adsorption were obtained on the basis of N-grafted copolymers of chitosan with polyethylene glycol (PEG) or dextran (DEX). The copolymers with the backbone molecular weight of 18 and 450 kDa, side chains of PEG of 5.0 and 0.9 kDa, DEX of 6.0 kDa and the degree of amine groups substitution χSub as high as ∼0.25 were alternated with dextran sulfate (DS) to assemble up to 10 bilayer films. The film material contains 85±5% of water with virtually no effect of the copolymer structure...
October 5, 2018: Colloids and Surfaces. B, Biointerfaces
Mahboubeh Rezazadeh, Zahra Davatsaz, Jaber Emami, Farshid Hasanzadeh, Ali Jahanian-Najafabadi
PURPOSE: Local delivery of chemotherapeutic drugs to the lungs offers many advantages for lung cancer treatment compared to conventional systemic chemotherapy. In the present study, novel mixed polymeric micelles based on tocopheryl succinate-polyethylene glycol 1000 and 5000 Da (TPGS1K and TPGS5K) were synthesized and loaded with paclitaxel (PTX). Then, the optimized micelles were incorporated as colloidal drug delivery system into lactose carrier particles using a spray drying technique...
2018: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
Changwoo Nam, Tawanda J Zimudzi, Richard A Wiencek, T C Mike Chung, Michael A Hickner
In situ measurement of hydrocarbons in water is critical for assuring the safety and quality of drinking water and in environmental remediation activities such as the cleanup of oil spills. Thus, effective detection methods of hydrocarbons in aqueous environments are important and several methods have been used for this type of sensing, including spectroscopic techniques, fiber optic sensors, and chromatography. However, under aqueous conditions, small amounts of hydrocarbons are difficult to detect due to their low concentration in water and robust sensing of these types of compounds in an aqueous environment remains a challenging analytical task...
October 15, 2018: Analyst
Arturo González Raya, Ramón Coca Zúñiga, Eva Martín Salido
BACKGROUND: A rare and benign cause of isolated aspartate aminotransferase (AST) increase is due to the presence of macro aspartate aminotransferase (macro-AST). Macro-AST is not usually considered by clinicians, leading to a large number of unnecessary and even invasive tests before diagnosed. Most commonly used laboratory methods for detection of macro-enzymes are precipitation with polyethylene glycol (PEG), ultracentrifugation and gel filtration chromatography (GFC). METHODS: We report a case of an asymptomatic patient with persistent isolated AST elevation...
October 15, 2018: Journal of Clinical Laboratory Analysis
Upashi Goswami, Raghuram Kandimalla, Sanjeeb Kalita, Arun Chattopadhyay, Siddhartha Sankar Ghosh
Combination drug therapy has become an effective clinical practice for cancer treatment because of low cytotoxicity by the synergistic effect of each medicine. Luminescent Au nanoclusters (Au NCs) were formulated into spherical polyethylene glycol (PEG)-Au NC-encapsulated drug-sodium butyrate (NaB) composite nanoparticles (PEG-Au NC-NaB-NPs) in the presence of PEG and NaB. Their effect on cancer cells was investigated using bio imaging, unravelling the mechanism of the endocytosis pathway and combination therapeutic interventions with a plant-based antimalarial drug artesunate (ART)...
September 30, 2018: ACS Omega
Alberto Scalia, Alberto Varzi, Andrea Lamberti, Timo Jacob, Stefano Passerini
A dye-sensitized solar module (DSSM) and a high voltage all-solid-state electrochemical double layer capacitor (EDLC) are, for the first time, implemented in a compact Harvesting-Storage (HS) device. Conductive glass is employed as current collecting substrate for both DSSM and EDLC, leading to a robust and portable final structure. The photovoltaic section is constituted by a 4 series cells W-type module, while in the storage section an EDLC employing an ionic liquid-based polymeric electrolyte (a mixture of polyethylene oxide and N-butyl-N-methylpyrrolidinium bis(trifluoromethanesulfonyl)imide, PEO-Pyr14 TFSI) and activated carbon electrodes is used...
2018: Frontiers in Chemistry
Akram Assali, Omid Akhavan, Fatemeh Mottaghitalab, Mohsen Adeli, Rassoul Dinarvand, Shayan Razzazan, Ehsan Arefian, Masoud Soleimani, Fatemeh Atyabi
Introduction: MicroRNA-101 (miR-101) is an intense cancer suppressor with special algorithm to target a wide range of pathways and genes which indicates the ability to regulate apoptosis, cellular stress, metastasis, autophagy, and tumor growth. Silencing of some genes such as Stathmin1 with miR-101 can be interpreted as apoptotic accelerator and autophagy suppressor. It is hypothesized that hybrid microRNA (miRNA) delivery structures based on cationized graphene oxide (GO) could take superiority of targeting and photothermal therapy to suppress the cancer cells...
2018: International Journal of Nanomedicine
Makoto Kondo, Yoshiaki Hirano, Kazumi Kita, Anuraga Jayanegara, Hiro-Omi Yokota
Spent tea leaf contains high levels of crude protein, suggesting that it may be used as an alternative source for ruminant feeding. We assessed the nutritive characteristics of spent green tea leaf silage (GTS) and black tea leaf silages (BTS) in comparison with soybean meal (SBM) and alfalfa hay cube (AHC) using in vitro assay. The effects of tannin on the nutritive characteristics were also evaluated by adding polyethylene glycol (PEG) as a tannin-binding agent. The amount of gas production was greater for SBM, followed by AHC, GTS, and BTS...
October 14, 2018: Animal Science Journal, Nihon Chikusan Gakkaihō
Jessica D Rogers, E Michael Thurman, Imma Ferrer, James S Rosenblum, Morgan V Evans, Paula J Mouser, Joseph N Ryan
Polyethylene glycols (PEGs) and polypropylene glycols (PPGs) are frequently used in hydraulic fracturing fluids and have been detected in water returning to the surface from hydraulically fractured oil and gas wells in multiple basins. We identified degradation pathways and kinetics for PEGs and PPGs under conditions simulating a spill of produced water to shallow groundwater. Sediment-groundwater microcosm experiments were conducted using four produced water samples from two Denver-Julesburg Basin wells at early and late production...
October 15, 2018: Environmental Science. Processes & Impacts
Juan Zhao, Yancai Wang, Yingying Ma, Yangyang Liu, Beibei Yan, Lulu Wang
Deacetyl mycoepoxydience (DM) nanocrystals core were stabilized by the folate modified distearoylphosphatidyl ethanolamine-polyethylene glycol (DSPE-PEG2000 -FA) as the active-targeting stabilizer and D-α-tocopherol polyethylene glycol 1000 succinate (TPGS) as the reversion of multidrug resistance stabilizer, respectively. The DM nanocrystals was acted as the core and shelled by the polyethylene glycol-hyaluronic acid (PEG-HA). The optimal core-shell system demonstrated superior stability at 4 °C for 6 weeks by the stability study and higher dissolution velocity...
January 1, 2019: Carbohydrate Polymers
Le Li, Rui-Ying Bao, Tao Gao, Zheng-Ying Liu, Bang-Hu Xie, Ming-Bo Yang, Wei Yang
Improving the physical properties of biobased polymers using bionanofillers is essential to preserve its biodegradability. This work presents a dopamine-induced functionalization of cellulose nanocrystals (CNCs) with polyethylene glycol (PEG), to enhance the crystallization, mechanical and barrier properties of poly(L -lactic acid) (PLLA) bionanocomposites. The effect of molecular weight of grafted PEG on the properties of PLLA is also studied. PEGylation of CNCs significantly enhance the crystallization of PLLA, especially for CNCs functionalized with PEG of lower molecular weight, which lead to balanced strength and ductility, and 66...
January 1, 2019: Carbohydrate Polymers
Meredith Perkins, Julie Lowell, Christina Arnholt, Daniel MacDonald, Anita L Kerkhof, Steven M Kurtz, William M Mihalko
Increased joint laxity is associated with excessive polyethylene wear, but the correlation between laxity and metal wear has not been established. Fifteen necropsy-retrieved primary total knee replacements were mounted into a custom knee-testing machine that measured anterior-posterior, varus-valgus, and internal-external rotational laxity at 0°, 30°, 60°, and 90° of flexion. Inductively coupled plasma-mass spectrometry analysis was performed to measure the cobalt (Co), chromium (Cr), and titanium (Ti) concentrations in periprosthetic tissue samples...
2018: Journal of Long-term Effects of Medical Implants
Adam P Breceda, Michael J DeRogatis, Patrick Lee, Vincent J Vigorita, Eli Bryk, Paul S Issack
We present the case of a 38-year-old man who presented 7 years after primary total hip replacement with a fracture of the neck of a lateral flare femoral stem and catastrophic polyethylene wear. The unique design of the lateral flare hip stem has been shown previously to be associated with accelerated polyethylene wear, whereas the stem remains well fixed. The resultant polyethylene wear results in the harder cobalt chrome head abrading the titanium shell generating metallic debris. This may have resulted in proximal migration of the implant neck into the cup with subsequent neck-cup impingement and implant fracture...
2018: Journal of Long-term Effects of Medical Implants
Noriko Kuramoto, Tatsuya Wakahara, Yuichi Tamagawa, Takahiro Uchino, Masahiro Koseto, Manabu Kawakami, Michio Otsuki, Yoshimasa Aoki, Midori Ishibashi, Soji Kasayama, Satoru Sumitani, Masafumi Koga
BACKGROUND: It is known that an immunoglobulin abnormality affects various clinical laboratory measurements and leads to abnormal values. We experienced a case of monoclonal gammopathy of undetermined significance (MGUS) showing a falsely low plasma glycated albumin (GA) level. CASE REPORT: The patient was a 75-y-old male who visited our hospital for thrombocytosis identified during a medical checkup. Based on further examinations, he was diagnosed with MGUS (IgM-κ type)...
October 11, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Silvia Pescina, Gabriela Garrastazu, Elena Del Favero, Valeria Rondelli, Laura Cantù, Cristina Padula, Patrizia Santi, Sara Nicoli
Imiquimod (IMQ) is an immunostimulant drug topically used for the treatment of actinic keratosis and basal cell carcinoma. IMQ formulation and skin delivery is difficult because of its very low solubility in the most of pharmaceutical excipients and very poor skin penetration properties. The purpose of this study was to develop a microemulsion to optimize imiquimod skin delivery using d‑α‑tocopherol polyethylene glycol-1000 succinate (TPGS) as surfactant (so as to take advantage of its thickening properties) and isostearic acid as oil phase...
October 11, 2018: European Journal of Pharmaceutical Sciences
Luping Sha, Qinfu Zhao, Da Wang, Xian Li, Xiudan Wang, Xinyao Guan, Siling Wang
"Gate" engineered mesoporous silica nanoparticles (MSN) have been extensively applied in cancer theranostics. Due to the complexity of tumor development and progression, with chemotherapy alone, it has often been difficult to achieve a good therapeutic effect. Currently, it has been shown that the combination with photothermal therapy overcomes the shortcoming of chemotherapy. In most studies, the photothermal effect has proven to accelerate drug release from nanocarriers and ablate malignant cells directly, but the influence on the intracellular fate of nanocarriers remains unknown...
September 27, 2018: Journal of Colloid and Interface Science
Abhishesh Kumar Mehata, Shreekant Bharti, Priya Singh, Matte Kasi Viswanadh, Lakshmi Kumari, Poornima Agrawal, Sanjay Singh, Biplob Koch, Madaswamy S Muthu
Breast cancer, up-regulated with human epidermal growth factor receptor type-2 (HER-2) has led to the concept of developing HER-2 targeted anticancer therapeutics. Docetaxel-loaded D-α-tocopherol polyethylene glycol 1000 succinate conjugated chitosan (TPGS-g-chitosan) nanoparticles were prepared with or without Trastuzumab decoration. The particle size and entrapment efficiency of conventional, non-targeted as well as targeted nanoparticles were in the range of 126-186 nm and 74-78% respectively. In-vitro studies on SK-BR-3 cells showed that docetaxel-loaded non-targeted and HER-2 receptor targeted TPGS-g-chitosan nanoparticles have enhanced the cellular uptake and cytotoxicity with a promising bioadhesion property, in comparison to conventional formulation i...
October 4, 2018: Colloids and Surfaces. B, Biointerfaces
Lisa E Cole, Tracie L McGinnity, Lisa E Irimata, Tracy Vargo-Gogola, Ryan K Roeder
A preclinical murine model of hydroxyapatite (HA) breast microcalcifications (µcals), which are an important clinical biomarker for breast cancer detection, was used to investigate the independent effects of high affinity bisphosphonate (BP) ligands and a polyethylene glycol (PEG) spacer on targeted delivery of gold nanoparticles (Au NPs) for contrast-enhanced radiographic detection. The addition of BP ligands to PEGylated Au NPs (BP-PEG-Au NPs) resulted in five-fold greater binding affinity for targeting HA µcals, as expected, due to the strong binding affinity of BP ligands for calcium...
October 10, 2018: Acta Biomaterialia
Bullo Saifullah, Kalaivani Buskaran, Rabia Baby Shaikh, Farahnaz Barahuie, Sharida Fakurazi, Mohd Aris Mohd Moklas, Mohd Zobir Hussein
The treatment of cancer through chemotherapy is limited by its toxicity to healthy tissues and organs, and its inability to target the cancer site. In this study, we have designed an anticancer nanocomposite delivery system for protocatechuic acid (PCA) using graphene oxide⁻polyethylene glycol as the nanocarrier, and coated with folic acid (GO⁻PEG⁻PCA⁻FA) for targeting the cancer cells. The designed anticancer delivery system was found to show much better anticancer activity than the free drug PCA against liver cancer HEP-G2 cells and human colon cancer HT-29 cells; at same time, it was found to be less toxic to normal fibroblast 3T3 cells...
October 11, 2018: Nanomaterials
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