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https://www.readbyqxmd.com/read/29333911/the-challenge-of-pediatric-uveitis-tertiary-referral-center-experience-in-the-united-states
#1
Mariantonia Ferrara, Laura Eggenschwiler, Andrew Stephenson, Alyssa Montieth, Nakhoul Nakhoul, Rafael Araùjo-Miranda, C Stephen Foster
PURPOSE: To describe the distribution, clinical findings, visual outcomes, treatment, and complications of children with uveitis at a tertiary referral ophthalmic center. METHODS: Retrospective cohort study. We reviewed the medical records of all patients ≤16 years with uveitis referred to Massachusetts Eye Research and Surgery Institution from March 2005 to July 2016. RESULTS: Of 286 included children, 62.24% were female. Mean age of onset was 8...
January 15, 2018: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29330083/rationale-and-design-of-the-clinic-and-community-approaches-to-healthy-weight-randomized-trial
#2
Lauren Fiechtner, Meghan Perkins, Vincent Biggs, Nancy Langhans, Mona Sharifi, Giselle O'Connor, Sarah Price, Joseph Locascio, Karen Kuhlthau, Jo-Ann Kwass, Candace Nelson, Thomas Land, Matt Longjohn, Valerie Lawson, Katherine Hohman, Elsie M Taveras
BACKGROUND: Recent studies have demonstrated the effectiveness of family-centered, pediatric weight management programs in reducing childhood obesity. Yet, programs to optimize the care of low-income children with obesity are needed. We sought to examine the comparative effectiveness of two, potentially scalable pediatric weight management programs delivered to low-income children in a clinical or community setting. MATERIALS AND METHODS: The Clinic and Community Approaches to Healthy Weight trial is a randomized trial in two communities in Massachusetts that serve a large population of low-income children and families...
January 9, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29330062/fundus-densitometry-findings-suggest-optic-disc-hemorrhages-in-primary-open-angle-glaucoma-have-an-arterial-origin
#3
Jonathan C Chou, Clara C Cousins, John B Miller, Brian J Song, Lucy Q Shen, Michael A Kass, Janey L Wiggs, Louis R Pasquale
PURPOSE: To analyze optic disc hemorrhages (DH) associated with primary open-angle glaucoma by quantifying their geometric profile and comparing their densitometry with hemorrhages from retinal vein occlusions (RVO) and retinal macroaneurysms (MA), which have venous and arterial sources of bleeding, respectively. DESIGN: Retrospective cross-sectional study METHODS: Setting: Massachusetts Eye & Ear POPULATION: Fundus images of DH (n=40), MA (n=14), and RVO (n=25) were identified...
January 9, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29328171/sequential-fitting-and-separating-reflectance-components-for-analytical-bidirectional-reflectance-distribution-function-estimation
#4
Yu Lee, Chanki Yu, Sang Wook Lee
We present a sequential fitting-and-separating algorithm for surface reflectance components that separates individual dominant reflectance components and simultaneously estimates the corresponding bidirectional reflectance distribution function (BRDF) parameters from the separated reflectance values. We tackle the estimation of a Lafortune BRDF model, which combines a nonLambertian diffuse reflection and multiple specular reflectance components with a different specular lobe. Our proposed method infers the appropriate number of BRDF lobes and their parameters by separating and estimating each of the reflectance components using an interval analysis-based branch-and-bound method in conjunction with iterative K-ordered scale estimation...
January 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29325236/treatment-with-a-ghrelin-agonist-in-outpatient-women-with-anorexia-nervosa-a-randomized-clinical-trial
#5
Pouneh K Fazeli, Elizabeth A Lawson, Alexander T Faje, Kamryn T Eddy, Hang Lee, Fred T Fiedorek, Anne Breggia, Ildiko M Gaal, Rebecca DeSanti, Anne Klibanski
OBJECTIVE: To assess the effects of relamorelin-an agonist of the appetite-stimulating hormone ghrelin, which has effects on gastric emptying-on (1) weight gain and (2) gastric emptying in women with anorexia nervosa. METHODS: In a randomized, double-blind, placebo-controlled design, the effects of the ghrelin agonist relamorelin were studied in 22 outpatient women with anorexia nervosa, diagnosed using DSM-5 criteria. The study was conducted at the Massachusetts General Hospital Clinical Research Center between March 11, 2013, and February 26, 2015...
January 2, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29321302/rapid-seasonal-evolution-in-innate-immunity-of-wild-drosophila-melanogaster
#6
Emily L Behrman, Virginia M Howick, Martin Kapun, Fabian Staubach, Alan O Bergland, Dmitri A Petrov, Brian P Lazzaro, Paul S Schmidt
Understanding the rate of evolutionary change and the genetic architecture that facilitates rapid adaptation is a current challenge in evolutionary biology. Comparative studies show that genes with immune function are among the most rapidly evolving genes across a range of taxa. Here, we use immune defence in natural populations of Drosophila melanogaster to understand the rate of evolution in natural populations and the genetics underlying rapid change. We probed the immune system using the natural pathogens Enterococcus faecalis and Providencia rettgeri to measure post-infection survival and bacterial load of wild D...
January 10, 2018: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/29319472/state-variations-in-infant-mortality-by-race-and-hispanic-origin-of-mother-2013-2015
#7
T J Matthews, Danielle M Ely, Anne K Driscoll
Data from the National Vital Statistics System: -In 2013-2015, the infant mortality rate by state ranged from 4.28 per 1,000 live births in Massachusetts to 9.08 in Mississippi. -Among the 50 states and the District of Columbia (D.C.), the mortality rate for infants of non-Hispanic white women ranged from 2.52 in D.C. to 7.04 in Arkansas. -For infants of non-Hispanic black women, the mortality rate ranged from 8.27 in Massachusetts to 14.28 in Wisconsin. -The mortality rate for infants of Hispanic women ranged from 3...
January 2018: NCHS Data Brief
https://www.readbyqxmd.com/read/29317005/a-quantitative-systematic-review-and-meta-analysis-of-the-effectiveness-of-oral-cholera-vaccine-as-a-reactive-measure-in-cholera-outbreaks
#8
Patricia Schwerdtle, Coretta-Kings Onekon, Katrina Recoche
Introduction The efficacy of oral cholera vaccines (OCVs) in laboratory conditions has been established, and the World Health Organization (WHO; Geneva, Switzerland) has recommended their preventative use in high-risk settings. The WHO recommendation has not been fully operationalized, nor has it been extended to apply to the reactive use of OCVs in real field epidemic conditions due to concerns about potential resource diversion, feasibility, cost, and acceptability. The purpose of this study is to assess and synthesize existing evidence of OCV effectiveness when used reactively in real field conditions...
January 10, 2018: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29316599/polypropylene-mesh-sling-for-stress-urinary-incontinence-does-memory-shaping-of-the-polypropylene-mesh-matter
#9
Andrew Doering, Ali Azadi, David Doering, Donald R Ostergard
We report a case of a mid-urethral sling (Advantage Fit™, Boston Scientific Corporation, Marlborough, Massachusetts) freshly removed from its original package. Upon removal from the packaging, the sling was noted to have a deformation in positioning at the midpoint, with curvature opposite the natural curve of the sling in the body. The images show the comparison to a sling with the desired positioning. Mid-urethral slings are commonly made from polypropylene mesh which has memory properties. It is important that manufacturers ensure that any steps in the processing or packaging of slings do not result in changes in the shape of the sling that may have unknown impacts on its clinical outcome...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29313949/cancer-statistics-2018
#10
Rebecca L Siegel, Kimberly D Miller, Ahmedin Jemal
Each year, the American Cancer Society estimates the numbers of new cancer cases and deaths that will occur in the United States and compiles the most recent data on cancer incidence, mortality, and survival. Incidence data, available through 2014, were collected by the Surveillance, Epidemiology, and End Results Program; the National Program of Cancer Registries; and the North American Association of Central Cancer Registries. Mortality data, available through 2015, were collected by the National Center for Health Statistics...
January 4, 2018: CA: a Cancer Journal for Clinicians
https://www.readbyqxmd.com/read/29306882/similarity-of-chest-x-ray-and-thermal-imaging-of-focal-pneumonia-a-randomised-proof-of-concept-study-at-a-large-urban-teaching-hospital
#11
Linda T Wang, Robert H Cleveland, William Binder, Robert G Zwerdling, Caterina Stamoulis, Thomas Ptak, Mindy Sherman, Kenan Haver, Pallavi Sagar, Patricia Hibberd
OBJECTIVE: To assess the diagnostic accuracy of thermal imaging (TI) in the setting of focal consolidative pneumonia with chest X-ray (CXR) as the gold standard. SETTING: A large, 973-bed teaching hospital in Boston, Massachusetts. PARTICIPANTS: 47 patients enrolled, 15 in a training set, 32 in a test set. Age range 10 months to 82 years (median=50 years). MATERIALS AND METHODS: Subjects received CXR with subsequent TI within 4 hours of each other...
January 5, 2018: BMJ Open
https://www.readbyqxmd.com/read/29303871/a-systematic-evaluation-of-state-laws-governing-optometric-glaucoma-management-in-the-united-states-up-to-2015
#12
Kevin Chodnicki, Sachin Kalarn, Laura Quinn, Henry Jampel, Osamah Saeedi
PURPOSE: To describe state laws that govern the optometric practice of glaucoma management in the United States and to correlate those laws with state demographics up to 2015. MATERIALS AND METHODS: We performed a cross-sectional ecological study of the 50 United States and the District of Columbia. Regulations governing optometric scope of practice as written by each state Board of Optometry were reviewed. Specific optometric privileges assessed included: ability to manage glaucoma independently, use of diagnostic pharmaceutical agents, use of therapeutic pharmaceutical agents (including topical and oral steroids and other oral pharmaceutical agents), intravenous injections, intraocular injections, therapeutic lasers, presence of defined referral and co-management guidelines, and hours of yearly continuing education needed for glaucoma management...
January 4, 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29303441/a-cross-sectional-study-of-neurosurgical-department-chairs-in-the-united-states
#13
Patrick M Flanigan, Arman Jahangiri, Joshua L Golubovsky, Jaret M Karnuta, Francis J May, Mitchel S Berger, Manish K Aghi
OBJECTIVE The position of neurosurgery department chair undergoes constant evolution as the health care landscape changes. The authors' aim in this paper was to characterize career attributes of neurosurgery department chairs in order to define temporal trends in qualities being sought in neurosurgical leaders. Specifically, they investigated the hypothesis that increased qualifications in the form of additional advanced degrees and research acumen are becoming more common in recently hired chairs, possibly related to the increased complexity of their role...
January 5, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29303393/high-risk-prescribing-to-medicaid-enrollees-receiving-opioid-analgesics-individual-and-county-level-factors
#14
Sara E Heins, Mark J Sorbero, Christopher M Jones, Andrew W Dick, Bradley D Stein
BACKGROUND: Prescription opioid overdoses have increased dramatically in recent years, with the highest rates among Medicaid enrollees. High-risk prescribing includes practices associated with overdoses and a range of additional opioid-related problems. OBJECTIVES: To identify individual- and county-level factors associated with high-risk prescribing among Medicaid enrollees receiving opioids. METHODS: In a four-states, cross-sectional claims data study, Medicaid enrollees 18-64 years old with a new opioid analgesic treatment episode 2007-2009 were identified...
January 5, 2018: Substance Use & Misuse
https://www.readbyqxmd.com/read/29302792/mitochondrial-bioenergy-alterations-in-avian-hd11-macrophages-infected-with-infectious-bronchitis-virus
#15
Sergio E L da Silva, Helena L Ferreira, Andrea F Garcia, Felipe E S Silva, Roberto Gameiro, Carolina U F Fabri, Dielson S Vieira, Tereza C Cardoso
To establish an association between mitochondrial dysfunction and apoptosis following infectious bronchitis virus (IBV) infection, HD11 avian macrophage cells were infected with the Massachusetts 41 (M41) strain. Our results show that the M41 strain of IBV induced cytopathic effects followed by the release of new viral particles. Elevated numbers of apoptotic cells were observed at 24, 48 and 72 h post-infection (p.i.). Viral infection was associated with mitochondrial membrane depolarization and reactive oxygen species (ROS) production at all of the examined timepoints p...
January 4, 2018: Archives of Virology
https://www.readbyqxmd.com/read/29298984/prenatal-counseling-on-type-2-diabetes-risk-exercise-and-nutrition-affects-the-likelihood-of-postpartum-diabetes-screening-after-gestational-diabetes
#16
Kai E Jones, Yan Yan, Graham A Colditz, Cynthia J Herrick
OBJECTIVE: Screening rates for type 2 diabetes after a pregnancy with gestational diabetes are inadequate. We aimed to determine how prenatal counseling on exercise, nutrition, and type 2 diabetes risk affects postpartum screening for diabetes. METHODS: Using Pregnancy Risk Assessment Monitoring System data from Colorado (2009-2011) and Massachusetts (2012-2013), we performed multivariable logistic regression to examine the relationship between prenatal counseling and postpartum screening...
January 3, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29295838/genetic-evidence-that-carbohydrate-stimulated-insulin-secretion-leads-to-obesity
#17
Christina M Astley, Jennifer N Todd, Rany M Salem, Sailaja Vedantam, Cara B Ebbeling, Paul L Huang, David S Ludwig, Joel N Hirschhorn, Jose C Florez
BACKGROUND: A fundamental precept of the carbohydrate-insulin model of obesity is that insulin secretion drives weight gain. However, fasting hyperinsulinemia can also be driven by obesity-induced insulin resistance. We used genetic variation to isolate and estimate the potentially causal effect of insulin secretion on body weight. METHODS: Genetic instruments of variation of insulin secretion [assessed as insulin concentration 30 min after oral glucose (insulin-30)] were used to estimate the causal relationship between increased insulin secretion and body mass index (BMI), using bidirectional Mendelian randomization analysis of genome-wide association studies...
January 2018: Clinical Chemistry
https://www.readbyqxmd.com/read/29295034/development-and-psychometrics-of-instruments-to-assess-school-personnel-s-bystander-action-in-situations-of-teen-relationship-abuse-and-sexual-assault
#18
Katie M Edwards, Stephanie N Sessarego, Linda R Stanley, Kimberly J Mitchell, Robert P Eckstein, Kara Anne E Rodenhizer, P Caroline Leyva, Victoria L Banyard
This article describes recently developed instruments that assess school personnel's bystander barriers and intentions in situations of teen relationship abuse, sexual assault, and sexual harassment, as well as perceptions of school readiness specific to relationship abuse, sexual assault, and sexual harassment prevention and response. Participants were 1,150 high school personnel from 25 schools in New Hampshire, Massachusetts, and Maine. Specific instruments focused on bystander intentions, bystander action, barriers to bystander action, and perceptions of school readiness...
December 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29294954/effects-of-a-home-visiting-program-on-parenting-mediating-role-of-intimate-partner-violence
#19
M Ann Easterbrooks, Rebecca C Fauth, Renee Lamoreau
Young women aged 18 to 24 years are in the highest risk group for intimate partner violence (IPV), and adolescent mothers are at particularly high risk for IPV and for risky health behaviors. Exposure to IPV may contribute to parenting stress and risky behaviors, and may compromise parenting behavior and healthy child development. The present study examined whether program effects of a statewide home visiting program for adolescent parents on young mothers' parenting stress and risky behaviors measured 2 years post program enrollment were mediated by program effects on their exposure to IPV measured 1 year post enrollment...
October 1, 2017: Journal of Interpersonal Violence
https://www.readbyqxmd.com/read/29294719/biological-evidence-in-adult-and-adolescent-sexual-assault-cases-timing-and-relationship-to-arrest
#20
Theodore P Cross, Megan Alderden, Alex Wagner, Lisa Sampson, Brittany Peters, Kaitlin Lounsbury
This study examined the timing of the crime laboratory report relative to arrests in sexual assault cases and explored the relationship between biological evidence and arrest in those cases in which the crime laboratory report came first and thus could have influenced the arrest decision. A random sample ( N = 528) of cases that occurred between 2008 and 2010 and included a report to police was drawn from a Massachusetts statewide database of medical reports on sexual assault cases. Data from medical providers were merged with data abstracted from crime laboratory reports and with data requested from police departments...
April 1, 2017: Journal of Interpersonal Violence
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