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Chris Richards is a Research Fellow at The Royal Veterinary College (RVC), UK, where he studies the evolution of the frog musculo-skeletal system. He received his Bachelor's degrees in Biology and Violin from Oberlin College, USA, in 1998 before completing his PhD with Andy Biewener at Harvard University, USA, in 2009. He then completed an independent Junior Fellowship at the Rowland Institute, Boston, USA, before moving to the RVC in 2014, where he currently holds a European Research Council grant.
November 19, 2018: Journal of Experimental Biology
(no author information available yet)
No abstract text is available yet for this article.
November 17, 2018: Veterinary Record
Berk Gonenc, Niravkumar Patel, Iulian Iordachita
Approximately 16.4 million people are affected by retinal vein occlusion (RVO) resulting from hypercoagulability, low blood flow or thrombosis in the central or the branched retinal veins. Most common current treatments for RVO aim to limit the damage. In recent years, an experimental procedure, retinal vein cannulation (RVC) has been studied in animal models as well as human eye models. RVC is a procedure for targeted delivery of a therapeutic agent into the occluded retinal vein for dissolving the thrombi...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Huahu Ye, Qiwei Wang
BACKGROUND/AIMS: Induced pluripotent stem cells (iPSCs) hold great promise for regenerative medicine, disease modeling, and drug development. Thus, generation of non-integration and feeder-free iPSCs is highly desirable for clinical applications. Peripheral blood mononuclear cells (PBMCs) are an attractive resource for cell reprogramming because of their properties of easy accessibility and the limited invasiveness of blood collection. However, derivation of iPSCs is technically demanding due to the low reprogramming efficiency and nonadherent features of PBMCs...
2018: Cellular Physiology and Biochemistry
Yanchao Jin, Yijun Shi, Riyao Chen, Xiao Chen, Xi Zheng, Yaoxing Liu
A reticulated vitreous carbon (RVC) cathode modified by anodic polarization in 20 wt% H2 SO4 solution was used for drinking water disinfection under a neutral low electrolyte concentration (0.25 g/L Na2 SO4 ) condition. The contribution of the modified RVC anode and the Ti/RuO2 cathode to disinfection was investigated. The influences of current, initial Escherichia coli load, temperature and water volume were studied. The results show that H2 O2 generation increased to approximately three times using the modification of the RVC...
January 2019: Chemosphere
Gaopeng Liu, Yonghou Jiang, Tanja Opriessnig, Keda Gu, Hongli Zhang, Zongqi Yang
Porcine viral diarrhea, mainly caused by porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), porcine group A rotaviruses (RVA), porcine group C rotaviruses (RVC) and porcine circovirus 2 (PCV2), is a serious global problem, resulting in substantial economic losses to the swine industry. For fast and reliable diagnosis of the causative agent associated with viral diarrhea in pigs, an inexpensive and easy to perform gel-based multiplex PCR assay was developed in this study to detect and differentiate the different viruses by amplicon size...
October 15, 2018: Journal of Virological Methods
Carolina C Rennó, Juliana Z B Papini, Cintia Maria Saia Cereda, Elizabeth Martinez, Victor Angelo Montalli, Eneida de Paula, José Pedrazzoli Júnior, Silvana Aparecida Calafatti, Giovana Radomille Tofoli
BACKGROUND: Our research group has recently developed liposomes with ionic gradient and in a combined manner as donor and acceptor vesicles containing ropivacaine (RVC; at 2% or 0.75%). Looking for applications of such novel formulations for postoperative pain control, we evaluated the duration of anesthesia, pharmacokinetics, and tissue reaction evoked by these new RVC formulations. METHODS: The formulations used in this study were large multivesicular vesicle (LMVV) containing sodium acetate buffer at pH 5...
October 9, 2018: Anesthesia and Analgesia
Claudio Fiorino, Calogero Gumina, Paolo Passoni, Anna Palmisano, Sara Broggi, Giovanni M Cattaneo, Alessandra Di Chiara, Antonio Esposito, Martina Mori, Roberta Raso, Monica Ronzoni, Riccardo Rosati, Najla Slim, Francesco De Cobelli, Riccardo Calandrino, Nadia G Di Muzio
PURPOSE: Introducing a radiobiological index based on early tumor regression during neo-adjuvant radio-chemotherapy (RCT, including oxaliplatin) of rectal adenocarcinoma and testing its discriminative power in predicting the tumor response. METHODS: Seventy-four patients were treated with Helical Tomotherapy following an adaptive (ART) protocol (41.4 Gy/18 fr, 2.3 Gy/fr) delivering a simultaneous integrated boost on the residual tumor in the last 6 fractions up to 45...
September 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Neidiane R Trindade, Paulo R Lopes, Lara M Naves, James O Fajemiroye, Pedro H Alves, Nathalia O Amaral, Luciano M Lião, Ana C S Rebelo, Carlos H Castro, Valdir A Braga, Ricardo Menegatti, Gustavo R Pedrino
The search for new antihypertensive drugs has grown in recent years because of high rate of morbidity among hypertensive patients and several side effects that are associated with the first-line medications. The current study sought to investigate the antihypertensive effect of a newly synthesized pyrazole derivative known as 5-(1-(3 fluorophenyl)-1H-pyrazol-4-yl)-2H-tetrazole (LQFM-21). Spontaneously hypertensive rats (SHR) were used to evaluate the effect of LQFM-21 on mean arterial pressure (MAP), heart rate (HR), renal vascular conductance (RVC), arterial vascular conductance (AVC), baroreflex sensitivity (BRS) index, and vascular reactivity...
2018: Frontiers in Physiology
C E Neville, S Montgomery, G Silvestri, A McGowan, E Moore, V Silvestri, C Cardwell, C T McEvoy, A P Maxwell, J V Woodside, G J McKay
BACKGROUND: Retinal vessel abnormalities are associated with cardiovascular disease risk. Widening of retinal venules is associated with increased risk of stroke while narrowing of retinal arterioles independently predicts incident hypertension, coronary heart disease and diabetes. Dietary factors are known to play an important role in cardiovascular health. However, few studies have examined the association between dietary patterns (DPs) and retinal microvascular health. OBJECTIVE: To examine the association between 'a posteriori'-derived DPs and retinal vascular caliber (RVC) in older women with a restricted lifestyle...
2018: Journal of Nutrition, Health & Aging
Fangdi Sun, Alexander Hall, Megan P Tighe, Cheryl L Brunelle, Hoda E Sayegh, Tessa C Gillespie, Kayla M Daniell, Alphonse G Taghian
PURPOSE: Despite increasing emphasis on screening and early intervention for breast cancer-related lymphedema (BCRL), there is marked heterogeneity in diagnostic methodology, including for volumetric measures. This retrospective study compared two volumetric modalities, perometry and simulated circumferential tape measurement (anatomic- and interval-based), for BCRL detection. METHODS: Between 2005 and 2017, 287 female patients with unilateral breast cancer were prospectively screened for BCRL by perometry and the relative volume change (RVC) formula...
November 2018: Breast Cancer Research and Treatment
Laura K Borkenhagen, Kerry A Mallinson, Rick W Tsao, Siaw-Jing Ha, Wei-Honn Lim, Teck-Hock Toh, Benjamin D Anderson, Jane K Fieldhouse, Sarah E Philo, Kuek-Sen Chong, William G Lindsley, Alejandro Ramirez, James F Lowe, Kristen K Coleman, Gregory C Gray
BACKGROUND: The large livestock operations and dense human population of Southeast Asia are considered a hot-spot for emerging viruses. OBJECTIVES: To determine if the pathogens adenovirus (ADV), coronavirus (CoV), encephalomyocarditis virus (EMCV), enterovirus (EV), influenza A-D (IAV, IBV, ICV, and IDV), porcine circovirus 2 (PCV2), and porcine rotaviruses A and C (RVA and RVC), are aerosolized at the animal-interface, and if humans working in these environments are carrying these viruses in their nasal airways...
2018: PloS One
Rowena Alves Coelho, Fábio Brito-Santos, Maria Helena Galdino Figueiredo-Carvalho, Juliana Vitoria Dos Santos Silva, Maria Clara Gutierrez-Galhardo, Antonio Carlos Francesconi do Valle, Rosely Maria Zancopé-Oliveira, Luciana Trilles, Wieland Meyer, Dayvison Francis Saraiva Freitas, Rodrigo Almeida-Paes
BACKGROUND: Chromoblastomycosis (CBM) is a difficult-to-treat chronic subcutaneous mycosis. In Brazil, the main agent of this disease is Fonsecaea pedrosoi, which is phenotypically very similar to other Fonsecaea species, differing only genetically. The correct species identification is relevant since different species may differ in their epidemiologic aspects, clinical presentation, and treatment response. METHODOLOGY/PRINCIPAL FINDINGS: Partial sequencing of the internal transcribed spacer (ITS) was used to identify twenty clinical isolates of Fonsecaea spp...
July 2018: PLoS Neglected Tropical Diseases
Ali Aldalbahi, Mostafizur Rahaman, Mohammed Almoiqli, Abdelrazig Hamedelniel, Abdulaziz Alrehaili
Acid-functionalized single-walled carbon nanotube (a-SWCNT)-coated reticulated vitreous carbon (RVC) composite electrodes have been prepared and the use of these electrodes in capacitive deionization (CDI) cells for water desalination has been the focus of this study. The performance of these electrodes was tested based on the applied voltage, flow rate, bias potential and a-SWCNT loadings, and then evaluated by electrosorption dynamics. The effect of the feed stream directly through the electrodes, between the electrodes, and the distance between the electrodes in the CDI system on the performance of the electrodes has been investigated...
July 13, 2018: Nanomaterials
(no author information available yet)
No abstract text is available yet for this article.
June 16, 2018: Veterinary Record
Elizabeth Armitage-Chan, Stephen A May
Professional studies teaching in medical and veterinary education is undergoing a period of change. Traditional approaches, aiming to teach students professional values and behaviors, are being enhanced by curricula designed to support students' professional identity formation. This development offers the potential for improving student engagement and graduates' mental well-being. The veterinary professional identity associated with emotional resilience and success in practice incorporates complexity in professional decision making and the importance of context on behaviors and actions...
June 13, 2018: Journal of Veterinary Medical Education
Diana Isela Sanchez-Alvarado, Javier Guzmán-Pantoja, Ulises Páramo-García, Alfredo Maciel-Cerda, Reinaldo David Martínez-Orozco, Ricardo Vera-Graziano
In this work, chitosan (CS)/poly (vinyl alcohol) (PVA) nanofibers were prepared by using the electrospinning method. Different CS concentrations (0.5, 1, 2, and 3 wt %), maintaining the PVA concentration at 8 wt %, were tested. Likewise, the studied electrospinning experimental parameters were: syringe/collector distance, solution flow and voltage. Subsequently, the electrospun fibers were collected on a reticulated vitreous carbon (RVC) support for 0.25, 0.5, 1, 1.5, and 2 h. The morphology and diameter of the CS/PVA nanofibers were characterized by scanning electron microscopy (SEM), finding diameters in the order of 132 and 212 nm; the best results (uniform fibers) were obtained from the solution with 2 wt % of chitosan and a voltage, distance, and flow rate of 16 kV, 20 cm, and 0...
June 9, 2018: International Journal of Molecular Sciences
D Zhang, Y Guan, L Fan, Y Xia, S Y Liu
Objective: To quantify emphysema and air trapping at inspiratory and expiratory phase multi-slice spiral CT(MSCT) scanning in smokers without respiratory symptoms, and analyze the correlation between the CT quantifiable parameters and lung function parameters. Methods: A total of 72 smokers, who underwent medical examinations from September 2013 to September 2016 in Changzheng Hospital were enrolled in this research and were divided into two groups: 24 smokers with COPD and 48 smokers without COPD.Besides, thirty-nine non-smokers with normal pulmonary function were enrolled as the controls...
May 22, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Yiming Mo, Klavs F Jensen
Electroorganic chemistry has emerged as an environmentally benign tool for synthetic chemists to achieve efficient transformations that are challenging with traditional reagent-based methods. Continuous flow chemistry brings pharmaceutical industry numerous advantages, but implementing electroorganic synthesis in flow is challenging, especially for electroorganic reactions with coupled electrode reactions and slow chemical reactions. We present a continuous electrolysis system engineered for N-hydroxyphthalimide (NHPI) mediated electrochemical aerobic oxidation of benzylic C-H bonds...
May 24, 2018: Chemistry: a European Journal
Jaime Onofre, Katrien Faes, Prashant Kadam, Elena Vicini, Ans M M van Pelt, Ellen Goossens
RESEARCH QUESTION: From a clinical perspective, which parameters grant optimal cryopreservation of mouse testicular cell suspensions? DESIGN: We studied the effect of different cryopreservation rates, the addition of sugars, different vessels and the addition of an apoptotic inhibitor on the efficiency of testicular cell suspension cryopreservation. After thawing and warming, testicular cell suspensions were transplanted to recipient mice for further functional assay...
July 2018: Reproductive Biomedicine Online
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