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https://www.readbyqxmd.com/read/30550207/-different-phenotypes-in-patients-with-chronic-sinusitis-with-bilateral-nasal-polyps
#1
Q Zhang, J F Ji, T Zhang, F Xue, M H Wu, Z Y Wang, L Xu, Y Cheng
Objective: To investigate the clinical features of patients with chronic sinusitis with bilateral nasal polyps. Method: The data of 134 patients with chronic sinusitis with bilateral nasal polyps were analyzed, retrospectively. Based on the results of the histopathological examination, patients were divided into eosinophilic chronic sinusitis with bilateral nasal polyps(ECRSwBNP) group and noneosinophilic chronic sinusitis with bilateral nasal polyps(nonECRSwBNP) group. The clinical data including medical history collection, skin prick test, nasal secretion examination, serum total IgE level, peripheral blood test, nasal endoscopy, and sinus CT examination were analyzed and compared...
December 5, 2018: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
https://www.readbyqxmd.com/read/30530593/tgf-%C3%AE-upregulated-mitochondria-mass-through-the-smad2-3%C3%A2-c-ebp%C3%AE-%C3%A2-prmt1-signal-pathway-in-primary-human-lung-fibroblasts
#2
Qingzhu Sun, Lei Fang, Xuemei Tang, Shemin Lu, Michael Tamm, Daiana Stolz, Michael Roth
Tissue remodeling of subepithelial mesenchymal cells is a major pathologic condition of chronic obstructive pulmonary disease and asthma. Fibroblasts contribute to fibrotic events and inflammation in both airway diseases. Recent mechanistic studies established a link between mitochondrial dysfunction or aberrant biogenesis leading to tissue remodeling of the airway wall in asthma. Protein arginine methyltransferase-1 (PRMT1) participated in airway wall remodeling in pulmonary inflammation. This study investigated the mechanism by which PRMT1 regulates mitochondrial mass in primary human airway wall fibroblasts...
December 10, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/30528365/question-3-can-we-diagnose-asthma-in-children-under-the-age-of-5-years
#3
REVIEW
C L Yang, J M Gaffin, D Radhakrishnan
The diagnosis of asthma in children under five years has been controversial due to changing concepts of what true asthma is in this age group. Previous diagnostic algorithms that used clinical indices to predict the persistence of asthma symptoms or phenotypes based on asthma triggers do not predict which children will benefit from asthma medication. A pragmatic approach to asthma diagnosis in this age group is based on identifying signs and symptoms of reversible airflow obstruction and documenting their response to asthma medication...
October 24, 2018: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/30517468/asthma-trend-in-adolescence-in-brazil-results-of-the-national-adolescent-school-based-health-survey-pense-2012-2015
#4
Rita de Cássia Ribeiro-Silva, Maurício Lima Barreto, Dandara Ramos, Alvaro Augusto Cruz, Maryane Oliveira-Campos, Deborah Carvalho Malta
OBJECTIVE: To compare the evolution of asthma indicators in the editions of the National School Health Survey (PeNSE 2012 and 2015). METHODS: Cross-sectional study including Brazilian 9th grade students from public and private schools. Wheezing was assessed through the question: "In the past 12 months, did you have wheezing (or chirping) chest? (yes/no)", and to assess lifetime presence of asthma, the question was "Have you ever had asthma? (yes/no)"...
November 29, 2018: Revista Brasileira de Epidemiologia, Brazilian Journal of Epidemiology
https://www.readbyqxmd.com/read/30504792/therapeutic-potential-of-ectopic-olfactory-and-taste-receptors
#5
REVIEW
Sung-Joon Lee, Inge Depoortere, Hanns Hatt
Olfactory and taste receptors are expressed primarily in the nasal olfactory epithelium and gustatory taste bud cells, where they transmit real-time sensory signals to the brain. However, they are also expressed in multiple extra-nasal and extra-oral tissues, being implicated in diverse biological processes including sperm chemotaxis, muscle regeneration, bronchoconstriction and bronchodilatation, inflammation, appetite regulation and energy metabolism. Elucidation of the physiological roles of these ectopic receptors is revealing potential therapeutic and diagnostic applications in conditions including wounds, hair loss, asthma, obesity and cancers...
November 30, 2018: Nature Reviews. Drug Discovery
https://www.readbyqxmd.com/read/30503672/changes-in-the-prevalence-of-asthma-and-related-risk-factors-in-adolescents-three-surveys-between-1994-and-2015
#6
J Mallol, V Aguirre, M Mallol-Simmonds, A Matamala-Bezmalinovic, L Calderón-Rodriguez, F Osses-Vergara
METHODS: This study assesses the temporal trend of current asthma symptoms prevalence and associated factors in Chilean adolescents from South-Santiago, considering surveys performed in 1994, 2002 and 2015. RESULTS: The prevalence of current asthma symptoms showed a trend to increase from 11.1% in 1994 to 13.4% in 2015 (p<0.001); physician-diagnosed asthma increased from 11.5% to 13.8%, (p<0.001) whereas severe asthma and asthma with exercise decreased (p<0...
November 29, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/30478238/being-overweight-or-obese-and-the-development-of-asthma
#7
Jason E Lang, H Timothy Bunnell, Md Jobayer Hossain, Tim Wysocki, John J Lima, Terri H Finkel, Leonard Bacharier, Amanda Dempsey, Lisa Sarzynski, Matthew Test, Christopher B Forrest
OBJECTIVES: Adult obesity is linked to asthma cases and is estimated to lead to 250 000 new cases yearly. Similar incidence and attributable risk (AR) estimates have not been developed for children. We sought to describe the relationship between overweight and obesity and incident asthma in childhood and quantify AR statistics in the United States for overweight and obesity on pediatric asthma. METHODS: The PEDSnet clinical data research network was used to conduct a retrospective cohort study (January 2009-December 2015) to compare asthma incidence among overweight and/or obese versus healthy weight 2- to 17-year-old children...
November 26, 2018: Pediatrics
https://www.readbyqxmd.com/read/30468531/diagnosis-validation-and-clinical-characterization-of-atopic-dermatitis-in-nurses-health-study-2
#8
A M Drucker, E Cho, W-Q Li, C A Camargo, T Li, A A Qureshi
BACKGROUND: Epidemiologic studies of atopic dermatitis are often limited by case definitions that have not been validated. OBJECTIVE: In this study, we assessed the accuracy of self-report of atopic dermatitis in a large cohort of US female nurses, the Nurses' Health Study 2 (NHS2). We also provide clinical characteristics of atopic dermatitis in the cohort. METHODS: We sent an electronic questionnaire to NHS2 participants who previously reported ever having a diagnosis of atopic dermatitis...
November 23, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/30467437/component-resolved-diagnosis-crd-of-food-anaphylaxis
#9
Małgorzata Bulanda, Magdalena Leśniak, Judyta Szałkowska, Weronika Madej, Agata Wojtyna, Maria Czarnobilska, Daniel Bulanda, Ewa Czarnobilska
Anaphylaxis is an increasing problem in public health. The food allergens (mainly milk, eggs, and peanuts) are the most frequent cause of anaphylaxis in children and youth. In order to define the cause of anaphylaxis, skin tests, the determination of the concentration of specific IgE in the blood and basophil activation test are conducted. In vitro tests are preferred due to the risk of allergic response during in vivo tests. Component-resolved diagnosis (CRD) is an additional tool in allergology, recommended in the third level of diagnostics when there are diagnostic doubts after the above mentioned tests have been carried out...
2018: Folia Medica Cracoviensia
https://www.readbyqxmd.com/read/30464017/immediate-bronchodilator-response-in-fev-1-as-a-diagnostic-criterion-for-adult-asthma
#10
REVIEW
Leena E Tuomisto, Pinja Ilmarinen, Lauri Lehtimäki, Minna Tommola, Hannu Kankaanranta
BACKGROUND: Asthma is characterised by variable and reversible expiratory airflow limitations. Thus, it is logical to use the change in FEV1 in response to a bronchodilator (ΔFEV1 BDR) as a diagnostic tool; increases of ≥12% and ≥200 mL from the baseline FEV1 are commonly used values. AIM: To evaluate the historical development of diagnostic cut-off levels for the ΔFEV1 BDR for adults and the evidence behind these recommendations. METHODS: We searched for studies from the reference lists of all the main statements, reports and guidelines concerning the interpretation of spirometry and diagnostics for asthma and conducted a literature search...
November 21, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/30461532/the-many-faces-of-asthma-chronic-obstructive-pulmonary-disease-overlap
#11
Louis-Philippe Boulet, Nicola A Hanania
PURPOSE OF REVIEW: Asthma and chronic obstructive pulmonary disease (COPD) are common diseases that often overlap. The term asthma-COPD overlap (ACO) has been used to define this entity but there remain several speculations on its exact definition, impact, pathophysiology, clinical features, and management. We reviewed recent publications on ACO to obtain more insight of current knowledge and outline future needs. RECENT FINDINGS: Criteria for ACO vary from one publication to another and the many variable features of these patients underline the need to reconsider the evaluation and approach of patients with overlapping features based on clinical traits and underlying biological mechanisms...
January 2019: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/30461139/influence-of-contextual-factors-on-quality-of-primary-care-in-children-with-asthma
#12
Maria Ingemansson, Marina Jonsson, Peter Henriksson, Gunilla Hedlin, Inger Kull, Eva Wikström Jonsson, Ingvar Krakau, Anna Kiessling
OBJECTIVE: Asthma is a common chronic disease among children, quality assurance is thus important. Adherence to pre-specified quality indicators of practice guidelines could be used to assess the quality of asthma care. The aim was to estimate which contextual factors that had an influence on the primary health care centres (PHCs) adherence to the quality indicators as stated in the practice guidelines. METHOD: A pragmatic cross-sectional study was performed comprising 14 PHCs in Sweden...
November 21, 2018: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/30461044/diagnosing-atopic-dermatitis-in-infancy-questionnaire-reports-vs-criteria-based-assessment
#13
Christoffer Dharma, Diana L Lefebvre, Maxwell M Tran, Zihang Lu, Wendy Y W Lou, Padmaja Subbarao, Allan B Becker, Piush J Mandhane, Stuart E Turvey, Theo J Moraes, Meghan B Azad, Malcolm R Sears
BACKGROUND: Persisting atopic dermatitis (AD) is known to be associated with more serious allergic diseases at later ages; however, making an accurate diagnosis during infancy is challenging. We assessed the diagnostic performance of questionnaire-based AD measures with criteria-based in-person clinical assessments at age 1 year and evaluated the ability of these diagnostic methods to predict asthma, allergic rhinitis and food allergies at age 5 years. METHODS: Data relate to 3014 children participating in the Canadian Healthy Infant Longitudinal Development (CHILD) Study who were directly observed in a clinical assessment by an experienced healthcare professional using the UK Working Party criteria...
November 2018: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/30453867/managing-comorbid-conditions-in-severe-asthma
#14
Philip G Bardin, Jhanavi Rangaswamy, Shaun W Yo
Asthma care has increasingly focused on personalised management for severe asthma, and recognition of the role and importance of comorbid conditions has increased. Severe asthma can be crippling; associated comorbid conditions often play a key role in the significant disease morbidity and frequently contribute to a severe and difficult-to-treat asthma phenotype. Comorbid conditions can be broadly grouped as being either airway-related or airway-unrelated. Airway-related comorbid conditions with the greatest impact are allergic rhinitis, chronic rhinosinusitis, vocal cord dysfunction, lung fungal sensitisation and underlying structural lung disease...
July 16, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/30453866/diagnosis-of-severe-asthma
#15
Tunn Ren Tay, Joy W-Y Lee, Mark Hew
Patients with asthma that is uncontrolled despite high intensity medication can present in both primary and specialist care. An increasing number of novel (and expensive) treatments are available for patients who fail conventional asthma therapy, but these may not be appropriate for all such patients. It is essential that a rigorous evaluation process be undertaken for these patients to identify those with biologically severe asthma who will require novel therapies, and those who may improve with control of contributory factors...
July 16, 2018: Medical Journal of Australia
https://www.readbyqxmd.com/read/30449614/asthma-rhinitis-and-nasal-polyp-multimorbidities
#16
José Antonio Castillo Vizuete, Joaquín Sastre, Alfonso Del Cuvillo Bernal, César Picado, Eva Martínez Moragón, José María Ignacio García, Carolina Cisneros Serrano, Francisco Javier Álvarez Gutiérrez, Joaquim Mullol Miret
The aim of this review is to assist pulmonologists in the management of diseases involving both the upper and lower respiratory tract that are linked by a common, interrelated epidemiology, clinical signs and symptoms, and inflammatory mechanism - asthma, in particular. The document discusses the definitions of the various sinonasal phenotypes associated with asthma: allergic and non-allergic rhinitis and chronic rhinosinusitis with or without nasal polyps. Diagnostic criteria and severity levels are also listed...
November 15, 2018: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/30430649/effects-of-lactobacillus-rhamnosus-hn001-in-early-life-on-the-cumulative-prevalence-of-allergic-disease-to-11-years
#17
Kristin Wickens, Christine Barthow, Edwin A Mitchell, Janice Kang, Noleen van Zyl, Gordon Purdie, Thorsten Stanley, Penny Fitzharris, Rinki Murphy, Julian Crane
BACKGROUND: In a two-centre randomized placebo-controlled trial of Lactobacillus rhamnosus HN001 (HN001) (6 × 109 colony-forming units [cfu]) or Bifidobacterium lactis HN019 (HN019) (9 × 109 cfu) taken daily from 35-week gestation to 6 months' post-partum in mothers while breastfeeding and from birth to age 2 years in infants, we showed that HN001 significantly protected against eczema development at 2, 4 and 6 years and atopic sensitization at 6 years. There was no effect of HN019...
November 14, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/30427975/genetic-clinical-and-environmental-factors-associated-with-persistent-atopic-dermatitis-in-childhood
#18
Sunna Thorsteinsdottir, Jakob Stokholm, Jacob P Thyssen, Sarah Nørgaard, Jonathan Thorsen, Bo L Chawes, Klaus Bønnelykke, Johannes Waage, Hans Bisgaard
Importance: Knowledge about factors associated with persistence of atopic dermatitis (AD) during childhood is sparse. Objective: To explore heritable, environmental, and clinical factors associated with persistent AD based on 13 years' follow-up of an at-risk birth cohort. Design, Setting, and Participants: In the Copenhagen Prospective Study on Asthma in Childhood 2000 (COPSAC2000) clinical birth cohort study, 411 children born to mothers with asthma were followed up until the age of 13 years at a clinical research unit in Copenhagen, Denmark, from August 1998 to June 2015...
November 14, 2018: JAMA Dermatology
https://www.readbyqxmd.com/read/30422985/machine-learning-to-identify-pairwise-interactions-between-specific-ige-antibodies-and-their-association-with-asthma-a-cross-sectional-analysis-within-a-population-based-birth-cohort
#19
Sara Fontanella, Clément Frainay, Clare S Murray, Angela Simpson, Adnan Custovic
BACKGROUND: The relationship between allergic sensitisation and asthma is complex; the data about the strength of this association are conflicting. We propose that the discrepancies arise in part because allergic sensitisation may not be a single entity (as considered conventionally) but a collection of several different classes of sensitisation. We hypothesise that pairings between immunoglobulin E (IgE) antibodies to individual allergenic molecules (components), rather than IgE responses to 'informative' molecules, are associated with increased risk of asthma...
November 2018: PLoS Medicine
https://www.readbyqxmd.com/read/30401321/assessment-of-atopic-dermatitis-as-a-risk-factor-for-chronic-spontaneous-urticaria-in-a-pediatric-population
#20
Nikolaos A Kitsioulis, Nikolaos G Papadopoulos, Sophia Kostoudi, Emmanouil Manousakis, Nikolaos Douladiris, Paraskevi Xepapadaki
Background: Atopic dermatitis (AD) and chronic spontaneous urticaria (CSU) represent two of the most common chronic inflammatory pruritic skin diseases. Any relationship between atopic skin disorders and CSU is controversial, mostly due to the paucity of relevant epidemiologic and pathogenetic data. Objective: To evaluate whether a history of AD in early childhood represents a risk factor for the subsequent occurrence of CSU in a pediatric population. Methods: Retrospective data of new cases of patients who visited the outpatient allergy unit of a tertiary pediatric hospital in Athens, Greece, between June 2014 and August 2016, were analyzed...
November 1, 2018: Allergy and Asthma Proceedings:
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