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Intravoxel incoherent motion

Rajikha Raja, Gary Rosenberg, Arvind Caprihan
Diffusion MRI studies characterizing the changes in white matter (WM) due to vascular cognitive impairment, which includes all forms of small vessel disease are reviewed. We reviewed the usefulness of diffusion methods in discriminating the affected WM regions and its relation to cognitive impairment. These studies were categorized based on the diffusion MRI techniques used. The most common method was the diffusion tensor imaging, whereas other methods included diffusion weighted imaging, diffusion kurtosis imaging, intravoxel incoherent motion, and studies based on diffusion tractography...
December 6, 2018: Neuroscience Letters
Lennart Well, Johannes M Salamon, Michael G Kaul, Said Farschtschi, Jochen Herrmann, Karin I Geier, Christian Hagel, Maximilian Bockhorn, Peter Bannas, Gerhard Adam, Victor F Mautner, Thorsten Derlin
Background: To determine the value of diffusion-weighted (DW) magnetic resonance imaging (MRI) for characterization of benign and malignant peripheral nerve sheath tumors (PNSTs) in patients with neurofibromatosis type 1 (NF1). Methods: Twenty-six patients with NF1 and suspicion of malignant transformation of PNSTs were prospectively enrolled, and underwent DW MRI at 3T. For a set of benign (n=55) and malignant (n=12) PNSTs, functional MRI parameters were derived from both biexponential intravoxel incoherent motion (diffusion coefficient D and perfusion fraction f) and monoexponential data analysis (apparent diffusion coefficients (ADCs))...
November 28, 2018: Neuro-oncology
Jing-Hua Pan, Shengbin Zhu, Jinlian Huang, Jianye Liang, Dong Zhang, Xiaoxu Zhao, Hui Ding, Li Qin, Changzheng Shi, Liangping Luo, Yunlong Pan
Tumor vascular normalization has been proposed as a new concept in anti-tumor angiogenesis, and the normalization window is considered as an opportunity to increase the effect of chemoradiotherapy. However, there is still a lack of a non-invasive method for monitoring the process of tumor vascular normalization. Intravoxel incoherent motion diffusion-weighted magnetic resonance imaging (IVIM DW-MRI) is an emerging approach which can effectively assess microperfusion in tumors, without the need for exogenous contrast agents...
2018: Frontiers in Oncology
D W Zong, C Y Guo, H L Li, H T Cheng, H T Hu, J C Xiao
Objective: To study the application of intravoxel incoherent motion (IVIM) quantitative index combined with time-signal intensity curve (TIC) of dynamic contrast enhanced 3.0T magnetic resonance in the early precise diagnosis of residual lesions in non-small cell lung cancer (NSCLC) after argon-helium cryosurgery. Methods: One hundred NSCLC patients who underwent argon-helium cryosurgery were collected and divided into the residual group (21 cases) and non-residual group (79 cases) according to the result of needle biopsy and follow-up...
November 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Q Peng, Y Huang, W Tang, N Wu, J W Wang, H Ouyang, S L Che, L B Hu, L L Qi
Objective: To explore the intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI) model in lung cancer patients with different histopathological subtypes. Methods: A total of 105 patients were recruited, including 68 cases of adenocarcinoma, 22 cases of squamous carcinoma and 15 cases of small cell carcinoma. All patients underwent magnetic resonance examination consisting of axial IVIM-DWI sequence on a 3.0 T whole body scanner, then the standard ADC (sADC), diffusion coefficient (D), pseudo-diffusion coefficient(D(*)), perfusion fraction (f), distributed diffusion coefficient (DDC) and water diffusion heterogeneity index (α) were calculated for each lesion within the IVIM-DWI model...
November 23, 2018: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
Antonella Petrillo, Roberta Fusco, Vincenza Granata, Salvatore Filice, Mario Sansone, Daniela Rega, Paolo Delrio, Francesco Bianco, Giovanni Maria Romano, Fabiana Tatangelo, Antonio Avallone, Biagio Pecori
Background: Our aim was to investigate preoperative chemoradiation therapy (pCRT) response in locally advanced rectal cancer (LARC) comparing standardized index of shape (SIS) obtained from dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) with intravoxel-incoherent-motion-modelling-derived parameters by diffusion-weighted imaging (DWI). Materials and methods: Eighty-eight patients with LARC were subjected to MRI before and after pCRT. Apparent diffusion coefficient (ADC), tissue diffusion (Dt ), pseudodiffusion (Dp ) and perfusion fraction (f) were calculated and percentage changes ∆ADC, ∆Dt , ∆Dp , ∆f were computed...
2018: Therapeutic Advances in Medical Oncology
Sophie van Baalen, Martijn Froeling, Marino Asselman, Caroline Klazen, Claire Jeltes, Lotte van Dijk, Bart Vroling, Pieter Dik, Bennie Ten Haken
PURPOSE: To compare diffusion tensor imaging (DTI), intravoxel incoherent motion (IVIM), and tri-exponential models of the diffusion magnetic resonance imaging (MRI) signal for the characterization of renal lesions in relationship to histopathological findings. METHODS: Sixteen patients planned to undergo nephrectomy for kidney tumour were scanned before surgery at 3 T magnetic resonance imaging (MRI), with T2 -weighted imaging, DTI and diffusion weighted imaging (DWI) using ten b-values...
November 26, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
Ivan I Maximov, Sebastian Vellmer
Perfusion magnetic resonance imaging (MRI) is a promising non-invasive technique providing insights regarding the brain's microvascular architecture in vivo. The scalar perfusion metrics can be used for quantitative diagnostics of various brain abnormalities, in particular, in the stroke cases and tumours. However, conventional MRI-based perfusion approaches such as dynamic contrast-enhanced perfusion imaging or arterial spin labelling have a few weaknesses, for instance, contrast agent deposition, low signal-to-noise ratio, limited temporal and spatial resolution, and specific absorption rate constraints...
November 22, 2018: Magnetic Resonance Imaging
Ming-Hui Song, Yan-Fang Jin, Jin-Song Guo, Lili Zuo, Hong Xie, Kaining Shi, Yun-Long Yue
BACKGROUND: Intravoxel incoherent motion (IVIM) parameters derived from iZOOM diffusion-weighted imaging (DWI) can be used to quantitatively identify malignant thyroid nodules. However, the criteria are not standardized. PURPOSE: To determine IVIM parameter values derived from iZOOM DWI that can differentiate malignant from benign thyroid nodules. MATERIAL AND METHODS: Forty-two patients with 46 pathologically confirmed thyroid nodules. All patients underwent preoperative examinations with conventional and iZOOM DWI...
November 20, 2018: Acta Radiologica
Lihua Chen, Tao Ren, Panli Zuo, Yingxin Fu, Shuang Xia, Wen Shen
BACKGROUND: Detecting renal allografts with impaired function early after renal transplantation and timely intervention are important to ensure a successful outcome. PURPOSE: To detect impaired function of renal allografts at the early stage after renal transplantation using intravoxel incoherent motion imaging (IVIM). MATERIAL AND METHODS: Forty-six recipients with good allograft function and 32 recipients with impaired function were included in this study...
November 17, 2018: Acta Radiologica
Niels Schurink, Doenja Lambregts, Regina Beets-Tan
This review summarizes current applications and clinical utility of diffusion-weighted imaging (DWI) for rectal cancer and in addition provides a brief overview of more recent developments (including intravoxel incoherent motion imaging, diffusion kurtosis imaging, and novel postprocessing tools) that are still in more early stages of research. More than 140 papers have been published in the last decade, during which period the use of DWI have slowly moved from mainly qualitative (visual) image interpretation to increasingly advanced methods of quantitative analysis...
November 15, 2018: British Journal of Radiology
Wen-Fei Li, Chen Niu, Tahir Mehmood Shakir, Tao Chen, Ming Zhang, Zhanqiu Wang
BACKGROUND: Differentiation of high-grade gliomas (HGGs) and low-grade gliomas (LGGs) is an important clinical problem because treatment strategies vary greatly. This study was performed to investigate the potential diagnostic value of incoherent intravoxel motion imaging (IVIM) to distinguish HGG from LGG by meta-analysis. METHODS: A computerized search of the literature was performed using the free-access PubMed database, Web of Science, and Chinese biomedical database, and relevant articles until September 18, 2018 that used IVIM to distinguish HGG from LGG were included...
November 2018: Medicine (Baltimore)
Stefanie J Hectors, Mathilde Wagner, Cecilia Besa, Wei Huang, Bachir Taouli
Purpose: To compare multiparametric (mp)FDG-PET/MRI metrics between hepatocellular carcinoma (HCC) and liver parenchyma and to assess the correlation between mpMRI and FDG-PET standard uptake values (SUVs) in liver parenchyma and HCC. Methods: This prospective, institutional review board-approved study enrolled 15 patients (M/F 12/3; mean age 61 y) with HCC. mpMRI including blood-oxygen-level-dependent (BOLD) MRI, intravoxel incoherent motion diffusion-weighted imaging (IVIM-DWI), and dynamic contrast-enhanced-(DCE-) MRI was performed simultaneously with 18 F-FDG-PET on a 3T PET/MRI hybrid system...
2018: Contrast Media & Molecular Imaging
Hou-Dong Zuo, Xiao-Ming Zhang
Gastrointestinal tumors (GTs) are among the most common tumors of the digestive system and are among the leading causes of cancer death worldwide. Functional magnetic resonance imaging (MRI) is crucial for assessment of histopathological changes and therapeutic responses of GTs before and after chemotherapy and radiotherapy. A new functional MRI technique, intravoxel incoherent motion (IVIM), could reveal more detailed useful information regarding many diseases. Currently, IVIM is widely used for various tumors because the derived parameters (diffusion coefficient, D; pseudo-perfusion diffusion coefficient, D*; and perfusion fraction, f) are thought to be important surrogate imaging biomarkers for gaining insights into tissue physiology...
October 28, 2018: World Journal of Radiology
Junqi Sun, Guangyao Wu, Feifei Shan, Zhihua Meng
RATIONALE AND OBJECTIVES: To investigate the value of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) in combination with conventional MRI in identifying the residual tumor after biopsy for early cervical carcinoma. MATERIALS AND METHODS: Eighty patients with histologically proven early cervical carcinoma were enrolled into this study. MRI sequences included two sets of MRI sequences including conventional MRI (T1WI, T2WI, and dynamic contrast-enhanced MRI) and IVIM DWI/conventional MRI combinations...
October 29, 2018: Academic Radiology
Roberta Fusco, Mario Sansone, Vincenza Granata, Robert Grimm, Ugo Pace, Paolo Delrio, Fabiana Tatangelo, Gerardo Botti, Antonio Avallone, Biagio Pecori, Antonella Petrillo
PURPOSE: To assess preoperative short-course radiotherapy (SCR) tumor response in locally advanced rectal cancer (LARC) by means of Standardized Index of Shape (SIS) by dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), apparent diffusion coefficient (ADC), intravoxel incoherent motion (IVIM) and diffusion kurtosis imaging (DKI) parameters derived from diffusion-weighted MRI (DW-MRI). MATERIALS AND METHODS: Thirty-four patients with LARC who underwent MRI scans before and after SCR followed by delayed surgery, retrospectively, were enrolled...
October 25, 2018: Abdominal Radiology
Genwen Hu, Zhong Yang, Wen Liang, Caiyong Lai, Yingjie Mei, Yufa Li, Jianmin Xu, Liangping Luo, Xianyue Quan
BACKGROUND: Renal fibrosis is a common consequence of chronic kidney disease (CKD) and is the mechanism by which various forms of CKD progress to endstage renal failure. Accurate assessment of renal fibrosis is important for treatment. PURPOSE: To measure longitudinal changes of intravoxel incoherent motion (IVIM) and arterial spin labeling (ASL) before and after reversible unilateral ureteral obstruction in an animal model. STUDY TYPE: Self-controlled animal study...
October 16, 2018: Journal of Magnetic Resonance Imaging: JMRI
Savio G Barreto, Ilse Dirkzwager, John A Windsor, Sanjay Pandanaboyana
BACKGROUND: Post-operative pancreatic fistulae (POPF) remain a major contributor to morbidity and mortality following pancreatic resection. Evidence for preoperative prediction of POPF based on cross-sectional imaging has not been systemically reviewed. This review aimed to determine whether preoperative imaging modalities can accurately predict the development of POPF. METHODS: A systematic review of major reference databases was undertaken, according to PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, up to May 2018...
October 10, 2018: ANZ Journal of Surgery
Markus Sauer, Christiane Klene, Michael Kaul, Azien Quitzke, Maxim Avanesov, Cyrus Behzadi, Lars Budäus, Dirk Beyersdorff, Gerhard Adam, Marc Regier
OBJECTIVES: To evaluate benign and malignant pelvine lymph nodes in prostate cancer patients with biexponential intravoxel incoherent motion (IVIM) MRI of the prostate prior to radical prostatectomy. METHODS: The ethics committee approved this retrospective study with waiver of informed consent. From February 2012 to November 2013 43 patients with histopathologically proven prostatic cancer were included. All patients were examined applying a standardized MRI protocol including IVIM diffusion weighted imaging with multiple b-values ranging from 0 to 950 s/mm²...
October 2018: European Journal of Radiology
Simona Marzi, Alessia Farneti, Antonello Vidiri, Francesca Di Giuliano, Laura Marucci, Filomena Spasiano, Irene Terrenato, Giuseppe Sanguineti
BACKGROUND: Functional magnetic resonance imaging may provide several quantitative indices strictly related to distinctive tissue signatures with radiobiological relevance, such as tissue cellular density and vascular perfusion. The role of Intravoxel Incoherent Motion Diffusion Weighted Imaging (IVIM-DWI) and Dynamic Contrast-Enhanced (DCE) MRI in detecting/predicting radiation-induced volumetric changes of parotids both during and shortly after (chemo)radiotherapy of oropharyngeal squamous cell carcinoma (SCC) was explored...
October 1, 2018: Radiation Oncology
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