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Jacob Korula
No abstract text is available yet for this article.
October 16, 2018: Annals of Internal Medicine
Justyna Augustyniak, Jacek Lenart, Paweł Gaj, Monika Kolanowska, Krystian Jazdzewski, Piotr Pawel Stepien, Leonora Buzanska
Bezafibrate (BZ) regulates mitochondrial biogenesis by activation of PPAR's receptors and enhancing the level of PGC-1α coactivator. In this report, we investigated the effect of BZ on the expression of genes (1) that are linked to different pathways involved in mitochondrial biogenesis, e.g., regulated by PPAR's receptors or PGC-1α coactivator, and (2) involved in neuronal or astroglial fate, during neural differentiation of hiPSC. The tested cell populations included hiPSC-derived neural stem cells (NSC), early neural progenitors (eNP), and neural progenitors (NP)...
October 13, 2018: Molecular Neurobiology
Leire Mijangos, Haizea Ziarrusta, Oihana Ros, Leire Kortazar, Luis Angel Fernández, Maitane Olivares, Olatz Zuloaga, Ailette Prieto, Nestor Etxebarria
In this study, the spatial and temporal-distribution of 41-multiclass organic compounds were assessed in three estuaries of the Basque Country, from winter 2016 to winter 2017 by grab (active) sampling methods and an extra campaign combining both, grab and passive sampling methods. Wastewater treatment plant (WWTP) effluents were also evaluated to assess their impact on the estuaries. Moreover, the physicochemical features (phosphate and nitrate concentrations, pH, etc.) of each site were measured and included in the statistical analysis...
September 29, 2018: Water Research
Yen-Ping Lin, Ying-Lin Lee, Chien-Ya Hung, Chuan-Fa Chang, Yi Chen
Helium, a minor component of natural gas and radioactive minerals, is most commonly used as a carrier in gas chromatography-mass spectrometry (GC-MS). Its scarcity leads to limited availability and higher costs. In this experiment, hydrogen from a safe source of a hydrogen generator was tested as a substitutive carrier gas for the detection of adulterant in traditional Chinese medicine (TCM) and food supplements by GC-MS analysis. We found that the limits of detection (LODs) of using hydrogen were from 10 to 1000 μg/g...
2018: PloS One
Bernardo Duarte, Diogo Prata, Ana Rita Matos, Maria Teresa Cabrita, Isabel Caçador, João Carlos Marques, Henrique N Cabral, Patrick Reis-Santos, Vanessa F Fonseca
Pharmaceutical residues impose a new and emerging threat to the marine environment and its biota. In most countries, ecotoxicity tests are not required for all pharmaceutical residues classes and, even when mandatory, these tests are not performed using marine primary producers such as diatoms. These microalgae are among the most abundant class of primary producers in the marine realm and key players in the marine trophic web. Blood-lipid-lowering agents such as bezafibrate and its derivatives are among the most prescribed drugs and most frequently found human pharmaceuticals in aquatic environments...
October 1, 2018: Science of the Total Environment
Laura B Ferguson, Lingling Zhang, Shi Wang, Courtney Bridges, R Adron Harris, Igor Ponomarev
Peroxisome proliferator activated receptors (PPARs) are nuclear hormone receptors that act as transcription factors in response to endogenous lipid messengers. The fibrates and thiazolidinediones are synthetic PPAR agonists used clinically to treat dyslipidemia and Type 2 Diabetes Mellitus, respectively, but also improve symptoms of several other diseases. Transposable elements (TEs), repetitive sequences in mammalian genomes, are implicated in many of the same conditions for which PPAR agonists are therapeutic, including neurodegeneration, schizophrenia, and drug addiction...
2018: Frontiers in Molecular Neuroscience
Banzragchgarav Orkhon, Kyoko Kobayashi, Batkhuu Javzan, Kenroh Sasaki
Continuous estrogen stimulation in the uterus has been known to cause excess proliferation of the functional layer of endometrium, resulting in endometrial hyperplasia and leading to infertility. Estrogens can modulate other nuclear receptor signaling pathways, such as peroxisome proliferator‑activated receptors (PPARs). Astragalus root (AsR) has exhibited strong PPARα agonistic activity. Female Imprinting Control Region mice were fed a powder diet that included 5% AsR hot water extract or 0.1% bezafibrate as a positive control for 56 days to investigate AsR effects on the reproductive tract, ovary and uterus...
September 19, 2018: Molecular Medicine Reports
Suhair H Jasim, Ghassan M Abu Sheikha, Haneen M Abuzaid, Tariq M Al-Qirim, Ghassan F Shattat, Dima A Sabbah, Samah A Ala, Mustafa S Aboumair, Kamal A Sweidan, Majdi M Bkhaitan
A new series of imidazole-5-carboxamide derivatives were prepared and tested for their anti-hyperlipidemic activity in Triton-WR-1339-induced hyperlipidemic Wistar rats. The purpose of this research was to improve benzophenone carboxamides water solubility maintaining at the same time the antihyperlipidemic activity. Compounds 4, 6, 10, and 11 were synthesized through a coupling reaction between imidazoles-5-carbonyl chloride and amino benzophenones. The tested animals (n=48) were divided into six groups: the first group (hyperlipidemic control group; HCG) received an intraperitoneal injection (i...
2018: Chemical & Pharmaceutical Bulletin
Lauren R Waskowicz, Jin Zhou, Dustin J Landau, Elizabeth D Brooks, Andrea Lim, Zollie A Yavarow, Tsubasa Kudo, Haoyue Zhang, Yajun Wu, Stuart Grant, Sarah P Young, Bay Boon Huat, Paul M Yen, Dwight D Koeberl
Glucose-6-phosphatase α (G6Pase) deficiency, also known as von Gierke's Disease or GSD Ia, is characterized by decreased ability of the liver to convert glucose-6-phosphate (G6P) to glucose leading to glycogen accumulation and hepatosteatosis. Long-term complications of GSD Ia include hepatic adenomas and carcinomas, in association with the suppression of autophagy in the liver. The G6pc-/- mouse and canine models for GSD Ia were treated with the pan-peroxisomal proliferator-activated receptor (PPAR) agonist, bezafibrate, to determine the drug's effect on liver metabolism and function...
September 25, 2018: Human Molecular Genetics
Andreas E Kremer, Aline Le Cleac'h, Sara Lemoinne, Katharina Wolf, Luc De Chaisemartin, Sylvie Chollet-Martin, Lydie Humbert, Dominique Rainteau, Raoul Poupon, Alexandra Rousseau, Olivier Chazouillères, Christophe Corpechot
No abstract text is available yet for this article.
September 18, 2018: Gut
Sho Tanaka, Takahiro Ueno, Akiko Tsunemi, Yoshihiro Nakamura, Hiroki Kobayashi, Yoshinari Hatanaka, Akira Haketa, Noboru Fukuda, Masayoshi Soma, Masanori Abe
A 40-year-old Japanese man presented with child-onset hypertriglyceridemia recently complicated by diabetes mellitus. The patient's diabetes mellitus was maintained, but he had persistent insulin resistance. The patient also had persistent severe hypertriglyceridemia (1,224-4,104 mg/dL), despite the administration of bezafibrate and ezetimibe. Type V dyslipidemia was revealed by agarose gel electrophoresis and the refrigerator test, and a significantly reduced post-heparin lipoprotein lipase mass of 26 ng/mL was confirmed...
September 12, 2018: Internal Medicine
Eunice Giselle López-Rocha, Gerardo Hernández-Montoya, Alberto Hernán Rodríguez-Pesina, Karen Alicia Rodríguez-Mireles
BACKGROUND: Allopurinol is a xanthine oxidase inhibitor used in the treatment of patients with gout. Approximately 2% of patients are affected by adverse reactions to this drug. Severity ranges from mild rashes to severe reactions in up to 0.4% of cases. De-sensitization is carried out by administering increasing doses of the drug. CASE REPORT: Thirty-year old man diagnosed with hypercholesterolemia and hypertriglyceridemia treated with bezafibrate and pravastatin, systemic arterial hypertension treated with losartan and a 10-year history of hyperuricemia with gout...
July 2018: Revista Alergia Mexico: Organo Oficial de la Sociedad Mexicana de Alergia e Inmunología, A.C
Daniela Avila-Smirnow, Audrey Boutron, María de Los Ángeles Beytía-Reyes, Oscar Contreras-Olea, Alfredo Caicedo-Feijoo, Roger Gejman-Enríquez, Raúl Escobar-Henríquez, Jorge Förster-Mujica
BACKGROUND: The myopathic form of carnitine palmitoyltransferase type II deficiency is an inherited autosomal recessive metabolic myopathy usually starting in childhood. Most reports have been on European and Japanese populations, and no Native South American patients have been reported to date. The p.Ser113Leu mutation is the most frequent in the European population. Only lower-leg magnetic resonance imaging findings have been reported, with gluteus maximus involvement in one case and normal imaging in other patients...
August 28, 2018: Journal of Medical Case Reports
Partha S Chowdhury, Kenji Chamoto, Alok Kumar, Tasuku Honjo
Although PD-1 blockade cancer immunotherapy has shown potential for a wide range of patients with cancer, its efficacy is limited, in part, due to the loss of effector cytotoxic T lymphocytes (CTLs) via terminal differentiation-induced apoptosis. We previously demonstrated that mitochondrial activation, by the agonists of peroxisome proliferator-activated receptor γ (PPARγ) coactivator 1-α (PGC-1α)/transcription factor complexes, had synergistic effects with a PD-1-blocking monoclonal antibody in a mouse tumor model...
August 24, 2018: Cancer Immunology Research
Dipak Kar, Arun Bandyopadhyay
BACKGROUND/AIMS: Morphological and biochemical maladaptation of cardiomyocytes are associated with mitochondrial dysfunction and dysregulation in hypertrophic conditions. Peroxisome proliferator activated receptor α (PPARα), a drug target for dyslipidemia, is known to be downregulated in cardiomyocytes in response to hypertrophic stimuli. The current study was undertaken to investigate the role of PPARα signaling in mitochondrial remodeling and thereby dysregulation of cardiomyocytes due to hypertrophy in vitro...
2018: Cellular Physiology and Biochemistry
Ying Li, Chi Yao, Daoping Zha, Wen Yang, Guanghua Lu
A passive sampling device, a polar organic chemical integrative sampler (POCIS), was used to monitor 13 pharmaceuticals and 8 transformation products in upstream and downstream wastewater treatment plant effluent. A POCIS laboratory calibration study was performed to determine uptake behavior and the effect of water flow on the sampling rate. Most compounds showed a linear accumulation, and the sampling rate values ranged from 0.031 to 0.559 L/day. The developed POCIS samplers were used in field experiments in a wastewater-impacted river...
November 2018: Chemosphere
Sara Lemoinne, Albert Pares, Anna Reig, Karima Ben Belkacem, Astrid Donald Kemgang Fankem, Farid Gaouar, Raoul Poupon, Chantal Housset, Christophe Corpechot, Olivier Chazouillères
BACKGROUND & AIMS: In patients with primary sclerosing cholangitis (PSC), ursodeoxycholic acid (UDCA) treatment improves serum liver tests and surrogate markers of prognosis but has no proven effect on survival. Additional therapies are obviously needed. Fibrates, PPAR agonists with anti-cholestatic properties, have a beneficial effect in primary biliary cholangitis. The aim of this study was to evaluate the safety and efficacy of fibrates in PSC patients. METHODS: Retrospectively, we investigated PSC patients treated with fibrates (fenofibrate 200mg/day or bezafibrate 400mg/day) for at least 6 months in addition to UDCA, after an incomplete biochemical response (alkaline phosphatase [ALP] ≥1...
August 9, 2018: Clinics and Research in Hepatology and Gastroenterology
Yaochun Yu, Ping Han, Li-Jun Zhou, Zhong Li, Michael Wagner, Yujie Men
Biotransformation of various micropollutants (MPs) has been found to be positively correlated with nitrification in activated sludge communities. To further elucidate the roles played by ammonia-oxidizing bacteria (AOB) and nitrite-oxidizing bacteria (NOB), we investigated the biotransformation capabilities of an NOB pure culture ( Nitrobacter sp.) and an AOB ( Nitrosomonas europaea)/NOB ( Nitrobacter sp.) coculture for 15 MPs, whose biotransformation was reported previously to be associated with nitrification...
August 21, 2018: Environmental Science & Technology
Miriam M Düll, Andreas E Kremer
Hepatic itch remains among the most agonizing symptoms for affected patients and a major clinical challenge for physicians. Pruritus may occur in almost all liver diseases, particularly those with cholestatic features. Hepatic itch arises irrespective of the severity of the underlying liver disease or extent of cholestasis. Antihistamines are ineffective in hepatic itch. Therapeutic recommendations consist of a guideline-based stepwise approach, starting with the anion exchange resin cholestyramine, followed by rifampicin, naltrexone, and sertraline...
July 2018: Dermatologic Clinics
Runalia Bahar, Kimberly A Wong, Chung H Liu, Christopher L Bowlus
Primary biliary cholangitis (PBC) is an autoimmune inflammatory liver disease of the interlobular bile ducts that can lead to cirrhosis and liver failure. Until recently, the only effective treatment was ursodeoxycholic acid (UDCA). However, up to 40% of PBC patients have an inadequate response to UDCA and may continue to have disease progression. Several models have been developed, including the UK-PBC and GLOBE scores, to assist in identifying patients who may benefit from second-line therapies, such as the farnesoid X receptor (FXR) agonist obeticholic acid (OCA)...
March 2018: Gastroenterology & Hepatology
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