Giuseppe Caruso, Claudia G Fresta, Angelita Costantino, Giacomo Lazzarino, Angela M Amorini, Giuseppe Lazzarino, Barbara Tavazzi, Susan M Lunte, Prajnaparamita Dhar, Massimo Gulisano, Filippo Caraci
Carbon-based nanomaterials are nowadays attracting lots of attention, in particular in the biomedical field, where they find a wide spectrum of applications, including, just to name a few, the drug delivery to specific tumor cells and the improvement of non-invasive imaging methods. Nanoparticles inhaled during breathing accumulate in the lung alveoli, where they interact and are covered with lung surfactants. We recently demonstrated that an apparently non-toxic concentration of engineered carbon nanodiamonds (ECNs) is able to induce oxidative/nitrosative stress, imbalance of energy metabolism, and mitochondrial dysfunction in microglial and alveolar basal epithelial cells...
March 7, 2021: International Journal of Molecular Sciences