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https://www.readbyqxmd.com/read/30314437/multimodal-mri-based-classification-of-migraine-using-deep-learning-convolutional-neural-network
#1
Hao Yang, Junran Zhang, Qihong Liu, Yi Wang
BACKGROUND: Recently, deep learning technologies have rapidly expanded into medical image analysis, including both disease detection and classification. As far as we know, migraine is a disabling and common neurological disorder, typically characterized by unilateral, throbbing and pulsating headaches. Unfortunately, a large number of migraineurs do not receive the accurate diagnosis when using traditional diagnostic criteria based on the guidelines of the International Headache Society...
October 11, 2018: Biomedical Engineering Online
https://www.readbyqxmd.com/read/30313071/risk-factors-of-transient-global-amnesia-three-case-reports
#2
Simona Portaro, Antonino Naro, Vincenzo Cimino, Giuseppa Maresca, Francesco Corallo, Rosa Morabito, Rocco Salvatore Calabrò
INTRODUCTION: Transient global amnesia (TGA) is characterized by a sudden onset of anterograde and retrograde amnesia, sometimes associated with mild subclinical neuropsychological deficits and vegetative symptoms, lasting for days after the episode. Migraine history, cardiovascular risk factors, and emotional stress are considered possible risk factors. TGA usually occurs during the seventh decade of life, that is, when risk factors and concomitant pathologies have a higher incidence...
October 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/30311219/the-future-of-migraine-prevention
#3
REVIEW
Robert P Cowan
Barring unforeseen circumstances, we anticipate the arrival of the first mechanism-specific class of molecules for migraine prevention in 2018. Despite many ground-breaking advances in the field over the last several years, these agents, broadly identified as calcitonin gene-related peptide-based pharmaceuticals, have captured the imagination and attention of the lay press and much of the headache community. This paper will address the factors, both class-specific and systems-based, that are likely to affect the launch, access, compliance, and adherence related to this new class, as well as attempt to place these novel medications in context of the current state and anticipated changes in headache medicine...
October 12, 2018: Headache
https://www.readbyqxmd.com/read/30311189/smart-not-always-only-stroke-like
#4
Vanessa Haller, David Dashti, Nils Peters
Stroke-like migraine attacks after radiation therapy (SMART) is a syndrome observed in a delayed fashion in patients following brain radiation therapy. It is a rare but important differential diagnosis of migraine in these patients, often presenting with migraine-like headache. In addition, there may be focal neurological deficits or seizures. In general, it is regarded as a reversible condition, therefore termed stroke-like. Our case illustrates that there may also be ischemic stroke associated with SMART leading to an unfavorable course, even after prior remission...
October 12, 2018: Headache
https://www.readbyqxmd.com/read/30311143/from-lbr-101-to-fremanezumab-for-migraine
#5
REVIEW
Marcelo E Bigal, Alan M Rapoport, Stephen D Silberstein, Sarah Walter, Richard J Hargreaves, Ernesto Aycardi
Calcitonin gene-related peptide (CGRP) is a neuropeptide of importance in migraine pathogenesis. Its central role in migraine was proven pharmacologically by the development of CGRP receptor antagonists. Monoclonal antibodies targeting CGRP or its receptor are effective in the preventive treatment of episodic and chronic migraine and are considered potential breakthroughs in their treatment. Fremanezumab (previously known as TEV-48125, LBR-101, or RN-307) is a humanized IgG2a monoclonal antibody that binds to CGRP...
October 11, 2018: CNS Drugs
https://www.readbyqxmd.com/read/30310310/to-what-extent-are-patients-with-migraine-able-to-predict-attacks
#6
Ana B Gago-Veiga, Josué Pagán, Kevin Henares, Patricia Heredia, Nuria González-García, María-Irene De Orbe, Jose L Ayala, Mónica Sobrado, Jose Vivancos
Purpose: Premonitory symptoms (PSs) of migraine are those that precede pain in a migraine attack. Previous studies suggest that treatment during this phase may prevent the onset of pain; however, this approach requires that patients be able to recognize their PSs. Our objectives were to evaluate patients' actual ability to predict migraine attacks based on their PSs and analyze whether good predictors meet any characteristic profile. Patients and methods: This prospective, observational study included patients with migraine with and without aura...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/30306317/clinical-manifestations-of-hydropic-ear-disease-meni%C3%A3-re-s
#7
Robert Gürkov, Claudia Jerin, Wilhelm Flatz, Rebecca Maxwell
INTRODUCTION: Hydropic ear disease, initially described by and named after Prosper Menière, is one of the most frequent vertigo disorders and one of the most frequent inner ear disorders. It is the syndrome of endolymphatic hydrops which until 2007 could be diagnostically confirmed only by post-mortem histology. In the past, various attempts to formulate clinical diagnostic criteria have been undertaken but were hampered by the inability to ascertain the diagnosis in living patients...
October 10, 2018: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/30305003/strong-association-between-migraine-and-transient-global-amnesia-a-national-inpatient-sample-analysis
#8
Minju Yi, Ayesha Z Sherzai, Chizobam Ani, David Shavlik, Mark Ghamsary, Evelyn Lazar, Dean Sherzai
The purpose of this article was to explore sex- and race-specific variables and comorbidities associated with transient global amnesia (TGA) using a nationally representative database. Data were obtained from the Nationwide Inpatient Sample using ICD-9 and procedure codes. Descriptive and survey logistic regression analyses were conducted and adjusted for influence of comorbidities, demographic characteristics, and hospitalization-related factors. Patients with migraines were 5.98 times more likely to also have a diagnosis of TGA compared with patients without migraines...
October 11, 2018: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/30304907/clinical-manifestations-of-headache-in-children-younger-than-7-years
#9
Bu Seon Kang, Jinsun Lee, Jin Hyuk Choi, Hyeok Hee Kwon, Joon Won Kang
Purpose: Headache is a common symptom during childhood. It is usually persistent and requires special care. This study aimed to identify the characteristics of headache in children <7 years of age. Methods: We reviewed 3 years of clinical files on children <7 years of age with a chief complaint of headache. Results: This study included 146 children (66 males, 80 females; mean age, 5.5 ± 1.0 years). Mean symptom duration was 5.8 ± 7...
September 16, 2018: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/30304742/vestibular-migraine-with-visual-aura-and-olfactory-hallucination-in-children-two-case-reports
#10
L M Agessi, T R Villa
BACKGROUND:  Approximately 3.9% children with migraine have olfactory hallucination which was defined as a perception of a smell without the substantial existence of any physical odor. CASE:  We described the first two cases of children with vestibular migraine, presenting visual aura and olfactory hallucination. ​ We reported two children with vertigo, visual aura, and olfactory hallucination before the headache who were responsive to topiramate. CONCLUSION:  The clinical description of olfactory hallucination presented some characteristics of migraine aura...
October 10, 2018: Neuropediatrics
https://www.readbyqxmd.com/read/30303941/can-a-chronic-bppv-with-a-history-of-trauma-be-the-trigger-of-symptoms-in-vestibular-migraine-myalgic-encephalomyelitis-chronic-fatigue-syndrome-me-cfs-and-whiplash-associated-disorders-wad-a-retrospective-cohort-study
#11
Carsten Tjell, Wenche Iglebekk, Peter Borenstein
BACKGROUND: In patients with chronic benign paroxysmal positional vertigo (BPPV), i.e., chronic vestibular multicanalicular canalithiasis (CVMCC), abnormal signals are transmitted from diseased labyrinths via the healthy vestibular nuclei complex to their end organs. The vestibulo-thalamo-cortical reflex as proposed in vestibular migraine is just one of these reflexes. In a group of patients diagnosed with CVMCC otolith repositioning maneuvers specific for each semicircular canal (SCC) ameliorated pain and other symptoms in 90%...
October 9, 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/30303542/intravenous-lidocaine-for-acute-pain-a-systematic-review
#12
Dalila Masic, Edith Liang, Christina Long, Ethan J Sterk, Brian Barbas, Megan A Rech
The purpose of this systematic review is to evaluate the safety and efficacy of intravenous (IV) lidocaine for the treatment of acute pain in adult patients. The PubMed database was searched for randomized controlled trials, retrospective cohort studies, case series, and case reports evaluating use of IV lidocaine for the treatment of acute pain in adult patients, published between January 1970 and January 2018. The primary outcome was pain reduction via Visual Analog Scale, Verbal Rating Scale, or Numeric Rating Scale among patients treated with IV lidocaine and placebo or active controls...
October 10, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/30301379/new-daily-persistent-headache-ndph-triggered-by-a-single-valsalva-event-a-case-series
#13
Todd D Rozen
Objective To describe a new subtype of new daily persistent headache that is triggered by a single Valsalva event. Methods A case series of patients was evaluated in an academic headache clinic over a 3-year time period. Results A total of seven patients (four female and three male) were diagnosed with this new subtype of new daily persistent headache. The headaches all began after a single Valsalva event. Average age at time of headache onset was 41 years (males: 39 years; females: 43 years) with an age range of 20-62 years...
October 9, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/30301194/headache-associated-with-coeliac-disease-a-systematic-review-and-meta-analysis
#14
REVIEW
Panagiotis Zis, Thomas Julian, Marios Hadjivassiliou
OBJECTIVE: The aim of this systematic review was to explore the relationship between coeliac disease (CD) and headache. The objectives were to establish the prevalence of each entity amongst the other, to explore the role of gluten free diet (GFD), and to describe the imaging findings in those affected by headaches associated with CD. METHODOLOGY: A systematic computer-based literature search was conducted on the PubMed database. Information regarding study type, population size, the age group included, prevalence of CD amongst those with headache and vice versa, imaging results, the nature of headache, and response to GFD...
October 6, 2018: Nutrients
https://www.readbyqxmd.com/read/30300458/the-high-burden-of-neurological-disease-in-the-older-general-population-results-from-the-canadian-longitudinal-study-on-aging
#15
Christina Wolfson, Seyed-Mohammad Fereshtehnejad, Romain Pasquet, Ron Postuma, Mark R Keezer
BACKGROUND: Our objective was to study the association between the presence of a neurological disease and the comorbidity burden, as well as healthcare utilization. METHODS: Using baseline data from the Canadian Longitudinal Study on Aging (CLSA), we examined the burden of five neurological conditions. The CLSA is a population-based study of approximately 50,000 individuals, aged 45 to 85 years at baseline. We used multivariable Poisson regression to identify correlates of comorbidity burden and healthcare utilization...
October 9, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/30298046/palinopsia-following-acute-unilateral-partial-vestibular-deafferentation-a-case-report
#16
Caterina Stafuzza, Theodore Landis, Jean-Philippe Guyot
Palinopsia is defined as the persistence or reappearance of images after cessation of the visual stimulus. One patient presented episodes of palinopsia after the functional loss of the 3 semicircular canals of the right ear while the otolithic function was preserved. None of classical causes was identified in this patient, intoxications, brain tumors, migraines, psychiatric disorders, etc. For a movement to be perceived as a single event, central processes of temporal integration are necessary to correct the shift between the rapid vestibular information, and the slow visual information...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30297353/relationship-between-right-to-left-shunt-and-migraine-in-patients-with-epilepsy-a-single-centre-cross-sectional-study-in-china
#17
Lin Zhang, Xi Zhu, Xiangmiao Qiu, Yajiao Li, Yucheng Chen, Hui Wang, Shixu He, Wanlin Lai, Anjiao Peng, Mingming Ning, Lei Chen
OBJECTIVES: To investigate the relationship between right-to-left shunt and migraine to account for the unexplained high prevalence of migraine in patients with epilepsy. DESIGN: This is a cross-sectional study. The diagnosis and interview process of patients with migraine was based on the International Classification of Headache Disorders-3 beta in patients with epilepsy. Participants underwent transthoracic echocardiography (TTE) with contrast medium to identify right-to-left shunt...
October 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/30297100/characteristics-and-clinical-correlates-of-white-matter-changes-in-brain-magnetic-resonance-of-migraine-females
#18
Iwona Rościszewska-Żukowska, Monika Zając-Mnich, Piotr Janik
OBJECTIVE: White matter hyperintensities (WMHs) were often found in migraine patients. The aim of study was to characterize WMHs, assess their prevalence, determine relationship to clinical symptoms and homocysteine levels in migraine females. METHODS: 69 women 38 with migraine without aura (MO), 31 with migraine with aura (MA) who underwent brain MRI with 1.5T scanner were enrolled. The WMHs number, location and size in FLAIR sequence were evaluated. Migraine severity was measured by pain intensity, number of attacks per month and MIDAS scale...
September 27, 2018: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/30296840/cerebral-autoregulation-in-migraine-with-aura-a-case-control-study
#19
Cédric Gollion, Nathalie Nasr, Nelly Fabre, Michèle Barège, Marc Kermorgant, Laurent Marquine, Vincent Larrue
Background Migraine with aura is independently associated with increased risk of ischemic stroke, especially in younger subjects. This association might be related to an impairment of cerebral autoregulation, which normally maintains cerebral blood flow independent of arterial blood pressure variations. Methods Patients aged 30-55, fulfilling ICHD-3 beta criteria for migraine with aura, were prospectively enrolled and compared with gender- and age-matched healthy controls without a history of migraine. Patients and controls with a history of stroke or any disease potentially impairing cerebral autoregulation were excluded...
October 8, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/30295375/postural-instability-during-attacks-of-migraine-without-aura
#20
Evangelos Anagnostou, Stathis Gerakoulis, Panagiota Voskou, Evangelia Kararizou
BACKGROUND AND PURPOSE: Migraine has long been associated with unsteadiness and dizziness but postural control has not been studied in the ictal state. Here, we measured the stability of upright stance during migraine attacks. METHODS: Static balance was assessed prospectively in migraine patients (n=30) during quiet stance for 40 s on a posturographic force platform. Recordings were performed both ictally and in the pain-free interval. Subjects were assessed under 4 different conditions yielding different visual and proprioceptive feedback environments...
October 8, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
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