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https://www.readbyqxmd.com/read/30097696/targeting-pericytes-for-therapeutic-approaches-to-neurological-disorders
#1
REVIEW
Jinping Cheng, Nils Korte, Ross Nortley, Huma Sethi, Yamei Tang, David Attwell
Many central nervous system diseases currently lack effective treatment and are often associated with defects in microvascular function, including a failure to match the energy supplied by the blood to the energy used on neuronal computation, or a breakdown of the blood-brain barrier. Pericytes, an under-studied cell type located on capillaries, are of crucial importance in regulating diverse microvascular functions, such as angiogenesis, the blood-brain barrier, capillary blood flow and the movement of immune cells into the brain...
August 10, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/30097147/multimodal-imaging-findings-during-severe-attacks-of-familial-hemiplegic-migraine-type-2
#2
Christian Roth, Andreas Ferbert, Monika Huegens-Penzel, Ralf Siekmann, Tobias Freilinger
BACKGROUND: Familial hemiplegic migraine (FHM) is a rare monogenic form of migraine with aura with three distinct genetic subtypes (FHM1-3). Imaging studies during acute FHM attacks are scarce in the literature. This is particularly true for the FHM2 subtype. PATIENTS AND METHODS: In this monocentric study, we retrospectively evaluated imaging data of four different patients with genetically confirmed FHM2. Analysis comprised a total of eight cMRI and two CT perfusion studies, which were obtained during a total of six different attacks...
September 15, 2018: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/30097135/benefits-of-an-on-line-migraine-education-video-for-patients-with-co-occurring-migraine-and-depression
#3
Elyse Thakur, Ana Recober, Carolyn Turvey, Lilian N Dindo
OBJECTIVE: To evaluate effects of an online, hour-long migraine education and management education program on health outcomes in people with migraine experiencing significant depressive symptoms. METHODS: Eligible individuals in the community with comorbid migraine and depressive symptoms (n = 95) participated in the 12-week study. Participants completed self-report questionnaires examining general functioning, headache-specific disability, migraine frequency, pain, and depressive symptoms, before, and at 2, 6, and 12 weeks following the migraine education and management program...
September 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/30095718/iv-lidocaine-for-status-migraine-making-an-off-label-treatment-decision
#4
Robert C Tasker
No abstract text is available yet for this article.
August 2018: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/30095537/visual-snow-visual-misperception
#5
Owen B White, Meaghan Clough, Allison M McKendrick, Joanne Fielding
BACKGROUND: Visual snow (VS) is a constant visual disturbance described as flickering dots occupying the entire visual field. Recently, it was characterized as the defining feature of a VS syndrome (VSS), which includes palinopsia, photophobia, photopsias, entoptic phenomena, nyctalopia, and tinnitus. Sixty percent of patients with VSS also experience migraine, with or without aura. This entity often is considered psychogenic in nature, to the detriment of the patient's best interests, but the high frequency of similar visual symptoms argues for an organic deficit...
August 7, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/30095163/sleep-and-migraine-assessment-and-treatment-of-comorbid-sleep-disorders
#6
Jeanetta C Rains
The relationship of sleep and migraine is unequivocal and familiarity with the nature and magnitude of these associations may inform clinical practice. Recent prospective, longitudinal, and time-series analysis has begun to unravel the magnitude and temporal patterns of sleep and migraine. Prospective evidence has shown that sleep variables can trigger acute migraine, precede and predict new onset headache by several years, and indeed, sleep disturbance and snoring are risk factors for chronification. The presence of a sleep disorder is associated with more frequent and severe migraine and portends a poorer headache prognosis...
August 10, 2018: Headache
https://www.readbyqxmd.com/read/30095015/comorbidity-of-migraine-and-epilepsy-in-pediatrics-a-review
#7
Jasna Jancic, Vesna Djuric, Boris Hencic, John N van den Anker, Janko Samardzic
Migraine and epilepsy are classified as chronic paroxysmal neurologic disorders sharing many clinical features, as well as possible treatment options. This review highlights the similarities between migraine and epilepsy in pediatrics, focusing on epidemiologic, pathophysiological, genetic, clinical, and pharmacologic aspects. Despite the fact that several syndromes share symptoms of both migraine and epilepsy, further research is needed to clarify the pathophysiological and genetic basis of their comorbidity...
August 10, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/30094981/-manual-acupuncture-stimulation-regulates-expression-of-receptor-activity-modifying-protein-1-and-5-ht-1-d-receptor-proteins-and-genes-in-migraine-rats
#8
Meng-Meng Wang, Xiao-Hua Yu, Wei Geng, Hua-Feng Cui, Chang-Chun Wang, Jing Han, Dian-Hui Yang
OBJECTIVE: To observe the effect of liver-soothing and mental-activity-regulating (LSMAR) needling on the expression of receptor activity-modifying protein 1 (RAMP 1, receptor of calcitonin gene-related peptide), 5-hydroxytryptamine 1 D receptor(5-HT 1 DR) in the spinal trigeminal nucleus (STN) and midbrain in migraine rats, so as to explore its underlying mechanism in relieving migraine. METHODS: A total of 40 male Wistar rats were randomly divided into control, model, LSMAR and conventional needling groups ( n =10 rats in each)...
July 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/30094686/the-risk-of-takotsubo-cardiomyopathy-in-acute-neurological-disease
#9
Nicholas A Morris, Abhinaba Chatterjee, Oluwayemisi L Adejumo, Monica Chen, Alexander E Merkler, Santosh B Murthy, Hooman Kamel
BACKGROUND: Case series have reported reversible left ventricular dysfunction, also known as stress cardiomyopathy or Takotsubo cardiomyopathy (TCM), in the setting of acute neurological diseases such as subarachnoid hemorrhage. The relative associations between various neurological diseases and Takotsubo remain incompletely understood. METHODS: We performed a cross-sectional study of all adults in the National Inpatient Sample, a nationally representative sample of US hospitalizations, from 2006 to 2014...
August 9, 2018: Neurocritical Care
https://www.readbyqxmd.com/read/30094517/intracortical-facilitation-within-the-migraine-motor-cortex-depends-on-the-stimulation-intensity-a-paired-pulse-tms-study
#10
Giuseppe Cosentino, Salvatore Di Marco, Salvatore Ferlisi, Francesca Valentino, Walter M Capitano, Brigida Fierro, Filippo Brighina
INTRODUCTION: Connectivity within the primary motor cortex can be measured using the paired-pulse transcranial magnetic stimulation (TMS) paradigm. This evaluates the effect of a first conditioning stimulus on the motor evoked potential (MEP) elicited by a second test stimulus when different interstimulus intervals are used. Aim of the present study was to provide, in patients suffering from migraine without aura (MwoA), additional information on intracortical facilitation (ICF), short intracortical inhibition (SICI), and long intracortical inhibition (LICI), using different intensities of the test stimulus (TS)...
August 9, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/30094042/case-report-the-role-of-oct-in-examination-of-a-patient-with-topiramate-induced-acute-angle-closure-acute-myopia-and-macular-striae
#11
Matías Osaba, Víctor Eduardo Reviglio
This work reports on a clinical case of a female who presented with headache, bilateral eye pain and vision loss. Intraocular pressures were 40 mm Hg in the right eye and 45 mm Hg in the left eye. Optical Coherence Tomography examination shows the iridocorneal angle was collapsed and macular striae were also observed. The patient had been on topiramate due to migraines 7 days before presentation. Diagnosis for topiramate-induced acute angle closure was made in both eyes. The patient showed improvement in symptoms a few days after treatment initiation and images confirmed that the iridocorneal angle had been enlarged and macular striae had disappeared...
July 2018: Oxford Medical Case Reports
https://www.readbyqxmd.com/read/30092648/neuronal-injuries-evidenced-by-transient-cortical-magnetic-resonance-enhancement-in-hemiplegic-migraine-a-case-report
#12
Arnaud Pellerin, Clémence Marois, Nicolas Mezouar, Karima Mokhtari, Delphine Leclercq, Bruno Law-Ye
Background Magnetic resonance imaging abnormalities in hemiplegic migraine have been described previously but were limited to a cortical thickening and biphasic alternation of hypoperfusion and hyperperfusion. Our report reveals possible blood-brain barrier disruption during migraine. Case We present the first demonstrated case of regressive diffuse hemispheric cortical enhancement in sporadic hemiplegic migraine, with histological correlation revealing neuronal lesions similar to ischemic lesions. This is probably due to the severity of the attack as indicated by the left hemiplegia and transient altered consciousness in our 43-year-old male patient...
August 9, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/30091544/-effect-of-manual-acupuncture-preconditioning-on-behavior-and-contents-of-serum-cgrp-sp-il-1-%C3%AE-and-tnf-%C3%AE-levels-in-migraine-rats
#13
Meng-Meng Wang, Xiao-Hua Yu, Wei Geng, Hua-Feng Cui, Chang-Chun Wang, Jing Han, Dian-Hui Yang
OBJECTIVE: To observe the effect of liver-soothing and mental-activity-regulating (LSMAR) needling on behavior reactions and contents of serum calcitonin gene-related peptide (CGRP), substance P (SP), interleukin-1 β (IL-1 β) and tumor necrosis factor-α (TNF-α) in migraine rats, so as to explore its mechanism underlying relief of migraine. METHODS: Thirty-two male Wistar rats were randomly divided into control, model, LSMAR needling and conventional needling groups ( n =8 rats in each)...
June 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/30091160/sleep-disorders-and-migraine-review-of-literature-and-potential-pathophysiology-mechanisms
#14
Angeliki Vgontzas, Jelena M Pavlović
Migraine shares a complex and poorly understood relationship with sleep. Patients consistently report poor sleep prior to migraine attacks and during them, identifying poor sleep as a migraine trigger. However, anecdotally, sleep is reported to serve a therapeutic role in terminating headache. Are the associations between migraine and sleep simply the result of various bidirectional relationships? A growing body of evidence suggests there may be a common underlying etiology as well. Our objective was to review studies of sleep and migraine from the last 2 decades utilizing validated subjective and objective measures of sleep and to explore potential mechanisms underlying this complex relationship by incorporating recent advances in neuroscience...
August 8, 2018: Headache
https://www.readbyqxmd.com/read/30090777/is-there-a-misuse-of-computed-tomography-in-the-diagnostic-workup-of-headache-a-retrospective-record-based-study-in-secondary-health-care-facility-in-saudi-arabia
#15
Ali Hassan A Ali, Sameer Al-Ghamdi, Mohammed H Karrar, Saud A Alajmi, Osama S Almutairi, Ahmed M Aldalbahi, Yazeed M Alotaibi, Sattam A Alruwaili, Abubaker Y Elamin
Introduction: Headache disorders are one of the most prevalent global public-health problems that require placing high demand on health-care Services. Since it is one of the most frequent complaints in clinical practice worldwide, it causes a considerable burden in terms of the social cost. The study aimed to give a guide for the decision on the utilization of computed tomography (CT) in the diagnostic workup and identify if patients require neurological imaging (CT) for proper diagnosis or not...
March 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/30089402/migraine-is-associated-with-high-brain-5-ht-levels-as-indexed-by-5-ht-4-receptor-binding
#16
Marie Deen, Anders Hougaard, Hanne D Hansen, Claus Svarer, Hans Eiberg, Szabolcs Lehel, Gitte M Knudsen, Messoud Ashina
Introduction Serotonin (5-HT) plays a role in migraine pathophysiology, but whether brain 5-HT is involved in the conversion from episodic to chronic migraine is unknown. Here, we investigated brain 5-HT levels, as indexed by 5-HT4 receptor binding, in chronic migraine patients and evaluated whether these were associated with migraine frequency. Methods Sixteen chronic migraine patients underwent a dynamic PET scan after injection of [11 C]SB207145, a specific 5-HT4 receptor radioligand. Data from 15 episodic migraine patients and 16 controls were included for comparison...
August 8, 2018: Cephalalgia: An International Journal of Headache
https://www.readbyqxmd.com/read/30089357/protein-and-chemical-determinants-of-bl-1249-action-and-selectivity-for-k2p-channels
#17
Lianne Pope, Cristina Arrigoni, Hubing Lou, Clifford Bryant, Alejandra Gallardo-Godoy, Adam R Renslo, Daniel L Minor
K2P potassium channels generate leak currents that stabilize the resting membrane potential of excitable cells. Various K2Ps are implicated in pain, ischemia, depression, migraine, and anesthetic responses, making this family an attractive target for small molecule modulator development efforts. BL-1249, a compound from the fenamate class of non steroidal anti inflammatory drugs is known to activate K2P2.1 (TREK-1), the founding member of the thermo- and mechanosensitive TREK subfamily; however, its mechanism of action and effects on other K2Ps are not well-defined...
August 8, 2018: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/30088106/pacap38-and-pac-1-receptor-blockade-a-new-target-for-headache
#18
Eloisa Rubio-Beltrán, Edvige Correnti, Marie Deen, Katharina Kamm, Tim Kelderman, Laura Papetti, Simone Vigneri, Antoinette MaassenVanDenBrink, Lars Edvinsson
Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is a widely distributed neuropeptide involved in neuroprotection, neurodevelopment, nociception and inflammation. Moreover, PACAP38 is a potent inducer of migraine-like attacks, but the mechanism behind this has not been fully elucidated.Migraine is a neurovascular disorder, recognized as the second most disabling disease. Nevertheless, the antibodies targeting calcitonin gene-related peptide (CGRP) or its receptor are the only prophylactic treatment developed specifically for migraine...
August 7, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/30087823/frequency-of-primary-headache-syndromes-in-patients-with-a-major-depressive-disorder
#19
Ather Muneer, Ahsen Farooq, Junaid H Farooq, Muhammad Siddique Qurashi, Immad A Kiani, Javeria S Farooq
Purpose The primary objective of this study was to assess the overall frequency of primary headaches in subjects with a moderate to severe major depressive disorder. A further objective was to determine the frequency of primary headache sub-types in this population. Materials and methods This descriptive, cross-sectional study was conducted at the outpatients' clinic of the department of psychiatry, Pakistan Railways Teaching Hospital, an affiliate of Islamic International Medical College, Rawalpindi. The duration of the study was from December 2016 to May 2017...
June 5, 2018: Curēus
https://www.readbyqxmd.com/read/30087728/an-investigation-of-the-prevalence-of-subclinical-brain-lesions-in-mri-images-of-migraine-patients
#20
Khadijeh Haji Naghi Tehrani
BACKGROUND: The use of the MRI method has opened up a new perspective on pathogenesis, diagnosis and treatment of brain lesions. AIM: Therefore, this study aimed to evaluate the prevalence of brain subclinical lesions in MRI images of migraine patients. METHODS: This cross-sectional study was conducted on 300 patients with a migraine referred to Baqiyatallah and Amir Al-Momenin Hospitals from 2005 to 2006. We measured the relationship between the results of MRI and the type of brain subclinical lesion by indices such as age, gender, type of a migraine, the number of migraine attacks, blood pressure and heart diseases, cholesterol, diabetes and thyroid diseases...
July 20, 2018: Open Access Macedonian Journal of Medical Sciences
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