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https://www.readbyqxmd.com/read/30120885/cryptococcal-infection-in-lung-transplant-recipients-a-five-year-retrospective-review-at-an-australian-transplant-centre
#1
Asma Sohail, Olivia C Smibert, Greg Snell, Miranda Paraskeva, Adam Jenney
INTRODUCTION: Cryptococcosis is a common invasive fungal infection (IFI) in solid organ transplant (SOT) recipients. Little is known about cryptococcosis in lung transplant (LTx) recipients despite having one of the highest risks of infection. AIM: To describe demographic and clinical features of cryptococcal infection in LTx recipients. MATERIALS AND METHODS: We performed a retrospective, observational study of cryptococcal infection in LTx recipients at The Alfred Hospital in Melbourne, Australia from 2012 to 2017...
August 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/30120841/tenofovir-alafenamide-taf-for-the-treatment-of-chronic-hepatitis-b-mono-infection
#2
Lindsey M Childs-Kean, Eric Egelund, Jacqueline Jourjy
Tenofovir alafenamide (TAF) is indicated for adult patients with chronic HBV infection with compensated liver disease at a dose of 25mg orally daily. TAF is a more stable prodrug in the plasma than tenofovir disoproxil fumarate (TDF), leading to decreased plasma exposure of tenofovir. Decreased exposure is thought to reduce the risk of long-term TDF toxicities, such as nephrotoxicity and decreased bone mineral density. TAF has the same mechanism of action as TDF: a nucleotide reverse transcriptase inhibitor...
August 18, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/30120600/pre-treatment-with-sumatriptan-for-cilostazol-induced-headache-in-healthy-volunteers
#3
Katrine Falkenberg, Jes Olesen
BACKGROUND: Previous studies indicate that sumatriptan is not effective when second messenger levels are high as after cilostazol provocation. Therefore, we have conducted the present study, where sumatriptan is administrated as pretreatment before cAMP increases due to cilostazol intake. Our hypothesis was that pretreatment with sumatriptan would have a significant effect against cilostazol induced headache in healthy volunteers. METHODS: In a double-blind, randomized, crossover design, 30 healthy volunteers of both sexes received cilostazol 200 mg on two separate days, each day preceded by oral sumatriptan (2 × 50 mg) or placebo...
August 17, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/30120560/cluster-headache-pathophysiology-diagnosis-and-treatment
#4
REVIEW
Srdjan Ljubisavljevic, Jasna Zidverc Trajkovic
Cluster headache (CH) is characterized by attacks of severe, strictly unilateral pain that is orbital, supraorbital, temporal, or any combination of these, lasts 15-180 min, and occurs from once every other day to eight times a day. The pain is associated with ipsilateral conjunctival injection, lacrimation, nasal congestion, rhinorrhea, forehead and facial sweating, miosis, ptosis and/or eyelid edema, and/or with restlessness or agitation. The understanding of the pathophysiological mechanisms behind CH is far from complete, but CH is considered to be a neurovascular and chronobiologic headache disorder, with a pivotal role played by the central brain mechanisms...
August 17, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/30120138/fremanezumab-for-preventive-treatment-of-migraine-functional-status-on-headache-free-days
#5
Juliana VanderPluym, David W Dodick, Richard B Lipton, Yuju Ma, Pippa S Loupe, Marcelo E Bigal
OBJECTIVE: To evaluate the effect of fremanezumab on the functional status on headache-free days in phase 2 episodic migraine (EM) and chronic migraine (CM) studies. METHODS: Functional status data were collected prospectively via the electronic headache diary on all headache-free days by patients answering questions regarding work/school/household chore performance, speed of work completion, concentration, and feeling of fatigue. Individuals with EM receiving monthly doses of fremanezumab 225 mg (n = 96) or 675 mg (n = 97) or placebo (n = 104) were compared...
August 17, 2018: Neurology
https://www.readbyqxmd.com/read/30120069/safety-and-immunogenicity-of-a-pentavalent-meningococcal-conjugate-vaccine-containing-serogroups-a-c-y-w-and-x-in-healthy-adults-a-phase-1-single-centre-double-blind-randomised-controlled-study
#6
Wilbur H Chen, Kathleen M Neuzil, C Rebecca Boyce, Marcela F Pasetti, Mardi K Reymann, Lionel Martellet, Nancy Hosken, F Marc LaForce, Rajeev M Dhere, Sambhaji S Pisal, Amol Chaudhari, Prasad S Kulkarni, Ray Borrow, Helen Findlow, Valerie Brown, Megan L McDonough, Len Dally, Mark R Alderson
BACKGROUND: Invasive meningococcal disease is an important public health problem, especially in sub-Saharan Africa. After introduction of MenAfriVac in 2010, Neisseria meningitidis serogroup A disease has been almost eliminated from the region. However, serogroups C, W, Y, and X continue to cause disease outbreaks. We assessed the NmCV-5 pentavalent meningococcal conjugate vaccine targeting A, C, Y, W, and X serogroups in a first-in-man, phase 1 study. METHODS: We did a single-centre, double-blind, randomised controlled trial at a research clinic in Baltimore (MD, USA)...
August 14, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/30118505/predicting-acute-renal-failure-in-bothrops-snakebite-patients-in-a-tertiary-reference-center-western-brazilian-amazon
#7
Eliane Campos Alves, Jacqueline de Almeida Gonçalves Sachett, Vanderson Souza Sampaio, José Diego de Brito Sousa, Sâmella Silva de Oliveira, Elizandra Freitas do Nascimento, Alessandra Dos Santos Santos, Iran Mendonça da Silva, Ana Maria Moura da Silva, Fan Hui Wen, Mônica Colombini, Marcus Vinicius Guimarães de Lacerda, Wuelton Marcelo Monteiro, Luiz Carlos de Lima Ferreira
Acute Kidney Injury (AKI) is the main systemic complication and cause of death in viperid envenomation. Although there are hypotheses for the development of AKI, the mechanisms involved are still not established. The aim of this study was to evaluate the clinical-laboratorial-epidemiological factors associated with AKI in victims of Bothrops sp envenomation. This is an observational study carried out at the Fundação de Medicina Tropical Dr. Heitor Vieira Dourado. AKI was defined according to the guidelines of the Acute Kidney Injury Network (AKIN)...
2018: PloS One
https://www.readbyqxmd.com/read/30117490/treatment-efficacy-of-ledipasvir-sofosbuvir-for-8-weeks-in-non-cirrhotic-chronic-hepatitis-c-genotype-4-patients
#8
Mohammed A Babatin, Abdullah S AlGhamdi, Abdullah M Assiri, Haziz AlBiladi, Hammad S AlOthmani, Mohammed H Mogharbel, Wedad Mahallawi, Tarik Asselah, Faisal M Sanai
Background/Aims: Ledipasvir/sofosbuvir (LDV/SOF) combination is administered for 12 to 24 weeks to treat hepatitis C virus (HCV); guidelines recommend 8 weeks treatment duration for HCV genotype (GT) 1 infection based on the patient's baseline characteristics. Data on treating HCV GT4 with LDV/SOF are limited. In this prospective cohort study, the efficacy and safety of 8 weeks treatment duration with LDV/SOF was evaluated in HCV GT4 patients in Saudi Arabia. Patients and Methods: Treatment-naïve, non-cirrhotic HCV GT4 patients received LDV/SOF for 8 weeks...
August 14, 2018: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/30117481/proptosis-and-hemiplegia-as-an-initial-manifestation-of-multiple-myeloma
#9
N Tahiliani, P Kataria, A Patel, P Kendre
Multiple myeloma (MM) is a monoclonal gammopathy, also known as the malignant proliferation of plasma cells, presenting with typical complications such as hypercalcemia, osteolytic bone lesions, anemia, renal insufficiency, and frequent infections. Central nervous system (CNS) involvement in MM in the form of parenchymal involvement is very uncommon and has been reported only in 1% of patients. CNS involvement as an initial presentation is very rare and has poor prognosis. Also specific treatment guidelines do not exist for the treatment of such patients...
August 17, 2018: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/30117023/clinical-neuroimaging-and-histopathological-features-of-gliomatosis-cerebri-a-systematic-review-based-on-synthesis-of-published-individual-patient-data
#10
Marios K Georgakis, Georgios Tsivgoulis, Dimitrios Spinos, Nikolaos G Dimitriou, Athanasios P Kyritsis, Ulrich Herrlinger, Eleni Th Petridou
INTRODUCTION: Gliomatosis cerebri (GC) is a rare fatal widespread infiltrating CNS tumor. As consistent disease features have not been established, the tumor comprises a diagnostic challenge. METHODS: We conducted a systematic literature search for published case reports and case series on patients with histologically confirmed GC. Clinical, diagnostic, neuroimaging, histopathological, and molecular data on individual or summary patient level were extracted and analyzed...
August 16, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/30116914/psychological-distress-neuroticism-and-disability-associated-with-secondary-chronic-headache-in-the-general-population-the-akershus-study-of-chronic-headache
#11
Espen Saxhaug Kristoffersen, Kjersti Aaseth, Ragnhild Berling Grande, Christofer Lundqvist, Michael Bjørn Russell
BACKGROUND: Primary headaches are associated with psychological distress, neuroticism and disability. However, little is known about headache-related disability and psychological distress among people with secondary chronic headaches. METHODS: 30,000 persons aged 30-44 from the general population was screened for headache by a questionnaire. The responder rate was 71%. The International Classification of Headache Disorders with supplementary definitions for chronic rhinosinusitis and cervicogenic headache were used...
August 3, 2018: Journal of Headache and Pain
https://www.readbyqxmd.com/read/30116528/atezolizumab-related-encephalitis-in-the-intensive-care-unit-case-report-and-review-of-the-literature
#12
Andrés Laserna, Sudhakar Tummala, Neel Patel, Diaa Eldin Mohamed El Hamouda, Cristina Gutiérrez
Atezolizumab is a monoclonal antibody that targets programmed death ligand-1. Treatments with this drug may cause immune-related adverse events by creating an exaggerated inflammatory response. The most common side effects are fatigue, rash, and gastrointestinal symptoms. Cases of central nervous system toxicity such as encephalitis and encephalopathy are uncommon. We present the case of a 53-year-old female with metastatic squamous cell carcinoma of the cervix who presented to the emergency room 13 days after receiving atezolizumab with altered mental status, headache, and meningeal signs...
2018: SAGE Open Medical Case Reports
https://www.readbyqxmd.com/read/30116511/large-de-novo-ascending-aortic-thrombus-successfully-treated-with-anticoagulation
#13
Mustafa Houmsse, Asia McDavid, Ahmet Kilic
An ascending aortic thrombus is a rare source for embolic transient ischemic attack (TIA) or stroke without an associated aortic pathology. Here we describe a case of a patient who presented with generalized symptoms of headache and fatigue who, on subsequent work-up , was found to have an ascending aortic thrombus with no obvious associated aortic pathology, and was successfully treated with apixaban, a newer direct oral anticoagulant.
2018: Journal of Cardiovascular and Thoracic Research
https://www.readbyqxmd.com/read/30116215/pain-perception-and-migraine
#14
REVIEW
Antonio Russo, Gianluca Coppola, Francesco Pierelli, Vincenzo Parisi, Marcello Silvestro, Alessandro Tessitore, Gioacchino Tedeschi
Background: It is well-known that both inter- and intra-individual differences exist in the perception of pain; this is especially true in migraine, an elusive pain disorder of the head. Although electrophysiology and neuroimaging techniques have greatly contributed to a better understanding of the mechanisms involved in migraine during recent decades, the exact characteristics of pain threshold and pain intensity perception remain to be determined, and continue to be a matter of debate. Objective: The aim of this review is to provide a comprehensive overview of clinical, electrophysiological, and functional neuroimaging studies investigating changes during various phases of the so-called "migraine cycle" and in different migraine phenotypes, using pain threshold and pain intensity perception assessments...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/30115602/-ictal-epileptic-headache-and-the-revised-international-headache-classification-ichd-3-published-in-cephalalgia-2018-vol-38-1-1-211-not-just-a-matter-of-definition
#15
EDITORIAL
Pasquale Parisi, Vincenzo Belcastro, Alberto Verrotti, Pasquale Striano, D G A Kasteleijn-Nolst Trenitè
No abstract text is available yet for this article.
August 13, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/30115365/clinical-manifestations-and-imaging-findings-of-thrombosis-of-developmental-venous-anomalies
#16
R Assadsangabi, S Mohan, S A Nabavizadeh
AIM: To determine clinical manifestations, imaging findings and outcome of patients with thrombosed developmental venous anomalies (DVAs). MATERIALS AND METHODS: The radiology database was searched retrospectively for thrombosed DVAs between 01/01/2000 to 07/01/2016. Demographic variables, associated risk factors, clinical manifestations, imaging findings, treatments, and follow-up were recorded. RESULTS: Six patients were found (four female and two male; age range 16-45 years with mean age, 21...
August 13, 2018: Clinical Radiology
https://www.readbyqxmd.com/read/30115336/guidelines-for-the-evaluation-and-treatment-of-pneumonia
#17
REVIEW
Samuel N Grief, Julie K Loza
Pneumonia is a common cause of respiratory infection, accounting for more than 800,000 hospitalizations in the United States annually. Presenting symptoms of pneumonia are typically cough, pleuritic chest pain, fever, fatigue, and loss of appetite. Children and the elderly have different presenting features of pneumonia, which include headache, nausea, abdominal pain, and absence of one or more of the prototypical symptoms. Knowledge of local bacterial pathogens and their antibiotic susceptibility and resistance profiles is the key for effective pharmacologic selection and treatment of pneumonia...
September 2018: Primary Care
https://www.readbyqxmd.com/read/30114544/a-frontal-tumefactive-demyelinating-lesion-mimicking-glioblastoma-differentiated-by-methionine-positron-emission-tomography
#18
Shoji Yasuda, Hirohito Yano, Akio Kimura, Natsuko Suzui, Noriyuki Nakayama, Jun Shinoda, Toru Iwama
BACKGROUND: Tumefactive demyelinating lesion (TDL) is often reported as a rare variation of multiple sclerosis (MS). TDL is difficult to diagnose solely by magnetic resonance imaging (MRI) in patients with no history of MS. This is because the lesion often shows ring enhancement with perifocal brain edema on gadolinium MRI, thus mimicking glioblastoma multiforme (GBM). CASE DESCRIPTION: A 54-year-old healthy woman complained of headache 1 month before admission...
August 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30114535/demonstration-of-infectious-transgression-through-the-skull-base-occurring-9-years-after-pituitary-adenoma-resection
#19
Jingyi Liu, David L Penn, Ethan Katznelson, Mina G Safain, Ian F Dunn, Edward R Laws
BACKGROUND: Sellar infections represent less than 1% of all sellar lesions and can be life-threatening. These infections occur de novo in up to 70% of patients, or can less commonly develop after surgical treatment of another primary lesion, such as a pituitary adenoma. CASE DESCRIPTION: We report a unique case of a 27 year-old woman with a recurrent pituitary adenoma treated with two prior transsphenoidal resections. She ultimately presented with hypopituitarism, followed by headaches, malaise, chills, and visual field and acuity deficits nine years after her second transsphenoidal resection...
August 13, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30113936/a-day-at-the-office-the-macra-sized-headache-part-1
#20
Douglas W Lundy
No abstract text is available yet for this article.
September 2018: Clinical Orthopaedics and related Research
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