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https://www.readbyqxmd.com/read/30106267/successful-treatment-of-psychosis-in-dentatorubral-pallidoluysian-atrophy-with-quetiapine-a-case-report
#1
Zui Narita, Tomiki Sumiyoshi
INTRODUCTION: Patients with dentatorubral-pallidoluysian atrophy (DRPLA) sometimes elicit psychosis. First-generation antipsychotic drugs have been reported to be effective in treating psychotic symptoms associated with the disease. However, little information is available on the benefits of second-generation antipsychotic drugs (SGAs). CASE: We report on a 47-year-old man with DRPLA whose psychotic symptoms were effectively treated with quetiapine, one of the SGAs...
March 2018: Neuropsychopharmacology reports
https://www.readbyqxmd.com/read/30022955/cortical-gray-matter-loss-augmented-vulnerability-to-speech-on-speech-masking-and-delusion-in-people-with-schizophrenia
#2
Chao Wu, Yingjun Zheng, Juanhua Li, Shenglin She, Hongjun Peng, Liang Li
People with schizophrenia exhibit impairments in target-speech recognition (TSR) against multiple-talker-induced informational speech masking. Up to date, the underlying neural mechanisms and its relationships with psychotic symptoms remain largely unknown. This study aimed to investigate whether the schizophrenia-associated TSR impairment contribute to certain psychotic symptoms by sharing underlying alternations in cortical gray-matter volume (GMV) with the psychotic symptoms. Participants with schizophrenia ( N = 34) and their matched healthy controls ( N = 29) were tested for TSR against a two-talker-speech masker...
2018: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/30017778/speech-structure-links-the-neural-and-socio-behavioural-correlates-of-psychotic-disorders
#3
Lena Palaniyappan, Natália Bezerra Mota, Shamuz Oowise, Vijender Balain, Mauro Copelli, Sidarta Ribeiro, Peter F Liddle
BACKGROUND: A longstanding notion in the concept of psychosis is the prominence of loosened associative links in thought processes. Assessment of such subtle aspects of thought disorders has proved to be a challenging task in clinical practice and to date no surrogate markers exist that can reliably track the physiological effects of treatments that could reduce thought disorders. Recently, automated speech graph analysis has emerged as a promising means to reliably quantify structural speech disorganization...
July 11, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29928594/speech-on-speech-masking-and-psychotic-symptoms-in-schizophrenia
#4
Chao Wu, Chuanyue Wang, Liang Li
People with schizophrenia have impairments of target-speech recognition (TSR) in noisy environments with multiple people talking. This study investigated whether the TSR impairment in schizophrenia is associated with their impaired auditory working memory or certain psychotic symptoms. Thirty participants with schizophrenia (mean age = 35.2 ± 12.7 years) and 30 demographics-matched healthy controls (mean age = 32.9 ± 10.9 years) were tested for their TSR against a two-talker-speech masker...
June 2018: Schizophrenia Research. Cognition
https://www.readbyqxmd.com/read/29703662/dysregulation-of-auditory-neuroplasticity-in-schizophrenia
#5
Patrice Voss, Maryse E Thomas, Gerson D Guercio, Etienne de Villers-Sidani
Schizophrenia is a complex brain syndrome characterized by an array of positive symptoms (delusions, hallucinations, disorganized speech), negative symptoms (alogia, apathy, avolition) and cognitive impairments (memory, executive functions). Although investigations of the cognitive deficits in schizophrenia have primarily concentrated on disturbances affecting higher-order cognitive processes, there is an increasing realization that schizophrenia also affects early sensory processing, which might, in fact, play a significant role in the development of higher-order cognitive impairments...
April 24, 2018: Schizophrenia Research
https://www.readbyqxmd.com/read/29692287/measuring-disorganized-speech-in-schizophrenia-automated-analysis-explains-variance-in-cognitive-deficits-beyond-clinician-rated-scales
#6
K S Minor, J A Willits, M P Marggraf, M N Jones, P H Lysaker
BACKGROUND: Conveying information cohesively is an essential element of communication that is disrupted in schizophrenia. These disruptions are typically expressed through disorganized symptoms, which have been linked to neurocognitive, social cognitive, and metacognitive deficits. Automated analysis can objectively assess disorganization within sentences, between sentences, and across paragraphs by comparing explicit communication to a large text corpus. METHOD: Little work in schizophrenia has tested: (1) links between disorganized symptoms measured via automated analysis and neurocognition, social cognition, or metacognition; and (2) if automated analysis explains incremental variance in cognitive processes beyond clinician-rated scales...
April 25, 2018: Psychological Medicine
https://www.readbyqxmd.com/read/29413227/to-use-the-brief-psychiatric-rating-scale-to-detect-disorganized-speech-in-schizophrenia-findings-from-the-reap-ap-study
#7
Yong Chon Park, Shigenobu Kanba, Mian-Yoon Chong, Adarsh Tripathi, Roy Abraham Kallivayalil, Ajit Avasthi, Sandeep Grover, Kok Yoon Chee, Andi J Tanra, Marigarita M Maramis, Shu-Yu Yang, Norman Sartorius, Chay-Hoon Tan, Naotaka Shinfuku, Seon-Cheol Park
Our study aimed to assess the psychometric validity of the conceptual disorganization item and other items of the Brief Psychiatric Rating Scale (BPRS) for detecting disorganized speech in patients with schizophrenia. We included 357 schizophrenia patients with disorganized speech and 1082 without disorganized speech from the survey centers in India, Indonesia, Japan, Malaysia, and Taiwan, using the data from the Research on Asian Psychotropic Patterns for Antipsychotics (REAP-AP) study. After adjusting the effects of confounding variables, a binary logistic regression model was fitted to identify BPRS items independently associated with disorganized speech...
February 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29162966/a-qsar-model-of-olanzapine-derivatives-as-potential-inhibitors-for-5-ht2a-receptor
#8
Pooja Mitra, Aishwarya Rastogi, Mayank Rajpoot, Ajay Kumar, Vivek Srivastava
Schizophrenia is a complex, chronic mental disorder, affecting about 21 million people worldwide. It is characterized by symptoms, including distortions in thinking, perception, emotions, disorganized speech, sense of self and behavior. Recently, a numbers of marketed drugs for Schizophrenia are available against dopamine D2 and serotonin 5-HT2A receptors. Here, we docked Olanzapine derivatives (collected from literature) with 5-HT2A Receptor using the program AutoDock 4.2. The docked protein inhibitor complex structure was optimized using molecular dynamics simulation for 5ps with the CHARMM-22 force field using NAMD (NAnoscale Molecular Dynamics program) incorporated in visual molecular dynamics (VMD 1...
2017: Bioinformation
https://www.readbyqxmd.com/read/29110334/frontotemporal-dementia-with-trans-activation-response-dna-binding-protein-43-presenting-with-catatonic-syndrome
#9
Ryohei Watanabe, Ito Kawakami, Mitsumoto Onaya, Shinji Higashi, Nobutaka Arai, Haruhiko Akiyama, Masato Hasegawa, Tetsuaki Arai
Catatonia is a clinical syndrome characterized by symptoms such as immobility, mutism, stupor, stereotypy, echophenomena, catalepsy, automatic obedience, posturing, negativism, gegenhalten and ambitendency. This syndrome occurs mostly in mood disorder and schizophrenic patients, and is related to neuronal dysfunction involving the frontal lobe. Some cases of frontotemporal dementia (FTD) with catatonia have been reported, but these cases were not examined by autopsy. Here, we report on a FTD case which showed catatonia after the first episode of brief psychotic disorder...
June 2018: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28982303/possible-garcinia-cambogia-induced-mania-with-psychosis-a-case-report
#10
David C Nguyen, Tysen K Timmer, Blair C Davison, Ian R McGrane
Garcinia cambogia is a Southeast Asian fruit becoming increasingly popular as a weight management supplement. Hydroxycitric acid (HCA) is the primary active ingredient which demonstrates serotonergic- and muscarinic-enhancing properties via inhibition of selective serotonin reuptake and acetylcholinesterase. We report a young adult female with no history of bipolar disorder who developed mania and psychosis approximately 1 week following initiation of G cambogia and the Cleanse and Detox™ dietary supplement manufactured by Apex Vitality Health...
January 1, 2017: Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28653797/neural-correlates-of-formal-thought-disorder-an-activation-likelihood-estimation-meta-analysis
#11
REVIEW
Tobias Wensing, Edna C Cieslik, Veronika I Müller, Felix Hoffstaedter, Simon B Eickhoff, Thomas Nickl-Jockschat
Formal thought disorder (FTD) refers to a psychopathological dimension characterized by disorganized and incoherent speech. Whether symptoms of FTD arise from aberrant processing in language-related regions or more general cognitive networks, however, remains debated. Here, we addressed this question by a quantitative meta-analysis of published functional neuroimaging studies on FTD. The revised Activation Likelihood Estimation (ALE) algorithm was used to test for convergent aberrant activation changes in 18 studies (30 experiments) investigating FTD, of which 17 studies comprised schizophrenia patients and one study healthy subjects administered to S-ketamine...
October 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28560723/impact-of-distress-related-to-attenuated-psychotic-symptoms-in-individuals-at-ultra-high-risk-of-psychosis-findings-from-the-longitudinal-youth-at-risk-study
#12
Gurpreet Rekhi, Attilio Rapisarda, Jimmy Lee
AIM: Recent studies have highlighted that attenuated psychotic symptoms (APS) are an important source of distress in ultra high risk (UHR) individuals and that this distress is related to transition to psychosis (TTP). This study examined distress associated with APS in UHR individuals and investigated its association with TTP. METHODS: The Comprehensive Assessment of At-Risk Mental State (CAARMS) was used to identify 173 UHR individuals, who were included as participants in the study...
May 31, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28560264/thought-disorder-measured-as-random-speech-structure-classifies-negative-symptoms-and-schizophrenia-diagnosis-6-months-in-advance
#13
Natália B Mota, Mauro Copelli, Sidarta Ribeiro
In chronic psychotic patients, word graph analysis shows potential as complementary psychiatric assessment. This analysis relies mostly on connectedness, a structural feature of speech that is anti-correlated with negative symptoms. Here we aimed to verify whether speech disorganization during the first clinical contact, as measured by graph connectedness, can correctly classify negative symptoms and the schizophrenia diagnosis 6 months in advance. Positive and negative syndrome scale scores and memory reports were collected from 21 patients undergoing first clinical contact for recent-onset psychosis, followed for 6 months to establish diagnosis, and compared to 21 well-matched healthy subjects...
2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/28437056/psychotic-and-bipolar-disorders-schizophrenia
#14
REVIEW
Alaina L Edmunds
Schizophrenia is the most common psychotic illness, typically appearing between the late teenage years and the mid-30s. The first episode of psychosis may be preceded by a prodromal period. Schizophrenia symptoms fall into six common symptom clusters: delusions and hallucinations, disorganization of speech, cognitive dysfunction, negative symptoms, affective symptoms, and motor system abnormalities. The diagnosis is based on criteria in the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, including exclusion of other possible medical or psychiatric etiologies of psychosis...
April 2017: FP Essentials
https://www.readbyqxmd.com/read/28276863/when-synesthesia-and-savant-abilities-are-mistaken-for-hallucinations-and-delusions-contribution-of-a-cognitive-approach-for-their-differential-diagnosis
#15
Lucie Bouvet, Jacques-Edouard Barbier, Nia Cason, Serge Bakchine, Nathalie Ehrlé
OBJECTIVE: Schizophrenia is characterized by hallucinations, delusions, disorganized speech and behavior, and other symptoms that cause social or occupational dysfunction. However, some of these symptoms, such as hallucinations and delusions, can be indicative of other phenomena such as synesthesia and savant abilities. The aim of this paper is to highlight how neurological and psychiatric conditions can be confused and how formal neuropsychological evaluations can be necessary to distinguish them...
November 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28104564/evidence-that-communication-impairment-in-schizophrenia-is-associated-with-generalized-poor-task-performance
#16
Anne M Merrill, Nicole R Karcher, David C Cicero, Theresa M Becker, Anna R Docherty, John G Kerns
People with schizophrenia exhibit wide-ranging cognitive deficits, including slower processing speed and decreased cognitive control. Disorganized speech symptoms, such as communication impairment, have been associated with poor cognitive control task performance (e.g., goal maintenance and working memory). Whether communication impairment is associated with poorer performance on a broader range of non-cognitive control measures is unclear. In the current study, people with schizophrenia (n =51) and non-psychiatric controls (n =26) completed speech interviews allowing for reliable quantitative assessment of communication impairment...
March 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28032254/white-matter-correlates-of-the-disorganized-speech-dimension-in-schizophrenia
#17
Petra V Viher, Katharina Stegmayer, Stéphanie Giezendanner, Andrea Federspiel, Stephan Bohlhalter, Roland Wiest, Werner Strik, Sebastian Walther
Disorganized speech is related to functional abnormalities in schizophrenia. To test the association between formal thought disorders (FTDs) and white matter microstructure, we applied a behavioral rating and diffusion tensor imaging in 61 patients with schizophrenia spectrum disorders. The Bern Psychopathology Scale was used to rate the dimension of language abnormalities ranging from negative FTDs, basically unaltered speech, to positive FTDs. Tract-based spatial statistics indicated increased fractional anisotropy in left hemispheric pathways of the language system in patients with negative FTDs...
February 2018: European Archives of Psychiatry and Clinical Neuroscience
https://www.readbyqxmd.com/read/27898489/inner-speech-and-clarity-of-self-concept-in-thought-disorder-and-auditory-verbal-hallucinations
#18
Paulo de Sousa, William Sellwood, Amy Spray, Charles Fernyhough, Richard P Bentall
Eighty patients and thirty controls were interviewed using one interview that promoted personal disclosure and another about everyday topics. Speech was scored using the Thought, Language and Communication scale (TLC). All participants completed the Self-Concept Clarity Scale (SCCS) and the Varieties of Inner Speech Questionnaire (VISQ). Patients scored lower than comparisons on the SCCS. Low scores were associated the disorganized dimension of TD. Patients also scored significantly higher on condensed and other people in inner speech, but not on dialogical or evaluative inner speech...
December 2016: Journal of Nervous and Mental Disease
https://www.readbyqxmd.com/read/27859274/configurations-of-time-the-body-and-verbal-communication-temporality-in-patients-who-express-their-suffering-through-the-body
#19
José Eduardo Fischbein
This paper focuses on the study of temporality used as a clinical pointer to processes of affect regulation in patients who express their suffering through a discourse driven by bodily allusions. Differences between symptoms revealed by body language that conveys an experience of conflict (psychoneurotic symptoms) and somatizations are reviewed. Somatization is examined as a benchmark for the failure to resolve states of tension. The body in the session is conceptualized as a speech event. The body is considered as a psychical construction organized in the exchanges with a fellow human-being...
April 2017: International Journal of Psycho-analysis
https://www.readbyqxmd.com/read/27858525/using-a-narrative-film-to-increase-knowledge-and-interpersonal-communication-about-psychosis-among-latinos
#20
Maria Y Hernandez, Yesenia Mejia, Doe Mayer, Steven R Lopez
Narrative communication is effective in increasing public awareness while generating dialogue about varied health topics. The current study utilized narrative communication in the form of a 15-minute motivational film titled La CLAve to help Latinos recognize symptoms of psychosis and begin a discussion about serious mental illness. The study aimed to explore the participants' response to the film and whether the film led to further dialogue about psychosis. Four focus groups were conducted with 40 Spanish-speaking participants, mostly foreign-born Latinas, with a mean age of 49 years...
December 2016: Journal of Health Communication
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