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 idiopathic thrombocytopenic purpura

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https://www.readbyqxmd.com/read/30531235/idiopathic-thrombocytopenic-purpura-induced-by-synthetic-cannabinoid
#1
Giselle Castaneira, Kelley Rojas, Yehuda Galili, Zachary Field, Ariel Perez-Perez, Mario Madruga, Steve J Carlan
: Idiopathic thrombocytopenic purpura (ITP) is an autoimmune disorder defined as low platelet count with normal bone marrow in the absence of other causes of thrombocytopenia. It is caused by autoantibodies binding to several platelet surface antigens which lead to premature destruction of the platelet by the reticuloendothelial system. ITP can be primary or secondary, and it is known to be associated with various infections and drugs. K2/Spice, or synthetic marijuana, acts on cannabinoid receptors CB1 (cannabinoid type-1) and CB2 (cannabinoid type-2) with increased binding capacity compared to marijuana...
November 29, 2018: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/30503656/causal-relationship-between-immunological-responses-and-adverse-reactions-following-vaccination
#2
REVIEW
Tetsuo Nakayama
Vaccine adverse events and controversial safety issues have occurred in recent decades in Japan: aseptic meningitis following the measles-mumps-rubella combined vaccine (MMR), anaphylaxis after immunization with live virus vaccines and inactivated split influenza vaccine, an increased incidence of febrile illness following the simultaneous administration of inactivated vaccines, and chronic pain with neurological illness after immunization with the human papilloma virus vaccine (HPV). Vaccine adverse events are a matter of concern for the public as well as general practitioners; some are within the range of assumptions that adverse reactions after live attenuated vaccines are related to the nature of their parental wild-type viruses...
November 29, 2018: Vaccine
https://www.readbyqxmd.com/read/30501715/-expression-and-clinical-significance-of-peripheral-blood-t-cell-jak2-stat3-mrna-in-chronic-idiopathic-thrombocytopenic-purpura
#3
Li Song, Ning-Chao DU, Fu-Rong Li, Fang Liu
OBJECTIVE: To detect the expression of JAK2/STAT3 mRNA in peripheral blood T cells from the patients with chronic idiopathic thrombocytopenic purpura(CITP), and to explore the relationship between JAK2/STAT3 mRNA and CITP. METHODS: CITP group and healthy control group were set in this study, The JAK2/STAT3 mRNA expression level in peropheral blood T cells of 2 groups was detected with the RT-PCR and agarose gel electrophoresis. RESULTS: JAK2 mRNA expression level in CITP group was significantly higher than that in control group(P<0...
December 2018: Zhongguo Shi Yan Xue Ye Xue za Zhi
https://www.readbyqxmd.com/read/30477462/platelet-count-on-preoperative-day-1-predicts-the-long-term-responses-to-laparoscopic-splenectomy-for-chinese-patients-with-medically-refractory-idiopathic-thrombocytopenic-purpura
#4
Rui Liao, Pei-Yuan Tang, Jun-Feng Song, Ke-Le Qin, Xun Wang, Xiong Yan
BACKGROUND: Laparoscopic splenectomy (LS) is regarded as a second-line treatment for medically refractory idiopathic thrombocytopenic purpura (ITP), but the predictive factors for the long-term postoperative responses to ITP are still a matter of debate. We aimed to investigate the factors that can predict the long-term response after LS for Chinese patients with medically refractory ITP. METHODS: From January 2011 to September 2016, 78 Chinese patients with ITP who underwent LS were retrospectively analyzed...
November 26, 2018: BMC Surgery
https://www.readbyqxmd.com/read/30471777/myh9-associated-nephropathy
#5
Mónica Furlano, Rosa Arlandis, María Del Prado Venegas, Silvana Novelli, Jaume Crespi, Gemma Bullich, Nadia Ayasreh, Ángel Remacha, Patricia Ruiz, Laura Lorente, José Ballarín, Anna Matamala, Elisabet Ars, Roser Torra
MYH9 related diseases are caused by mutations in the MYH9 gene and constitute a rare group of genetic entities. Its inheritance follows an autosomal dominant pattern. The MYH9 gene, encodes the nonmuscle myosin heavy chain IIA, expressed in different tissues and especially in podocytes and mesangial cells. The disorder is characterized by the presence of macrothrombocytopenia, leukocyte inclusions and a variable risk of developing renal failure, hearing loss and early-onset cataracts. We describe the case of a 27-year-old Caucasian woman, diagnosed initially with idiopathic thrombocytopenic purpura...
November 21, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/30470476/the-systematic-case-referent-method
#6
Lamiae Grimaldi-Bensouda, Lucien Abenhaim
The systematic case-referent method is a special case-referent design originally developed for pharmacoepidemiologic research purposes. It consists in the systematic collection of series of incident cases of various disorders and the assembling of a general reference pool, from which "controls" are secondarily selected to be matched to specific cases. Both series are collected independently from each other and with no a priori hypothesis to be investigated. The reference pool can be either general or limited to a subpopulation, representative of the source population of the cases...
October 26, 2018: Thérapie
https://www.readbyqxmd.com/read/30445832/analysis-of-chemical-components-in-herbal-formula-qi-bai-granule-by-uplc-esi-q-tof-ms
#7
Chengmeng Zhang, Yi He, Tingting Li, Xinglong Miao, Meiting Song, Changmin Qian, Ruiming Li
Qi Bai Granule (QBG), a traditional Chinese medicine formula for the treatment of idiopathic thrombocytopenic purpura, is composed of seven herbs. It is necessary to learn its chemical composition for quality control. In this study, a method for rapid separation and structural identification of the constituents in QBG was established by UPLC-ESI-Q-TOF-MS in negative and positive ion mode. As a result, 112 compounds, such as triterpenoids, flavonoids and monoterpenes were detected. Based on the retention times, accurate masses, fragment ions, related literatures, and/or authentic standards, 107 compounds were unambiguously identified or tentatively characterized...
November 16, 2018: Natural Product Research
https://www.readbyqxmd.com/read/30410491/a-wide-spectrum-of-autoimmune-manifestations-and-other-symptoms-suggesting-immune-dysregulation-in-patients-with-cartilage-hair-hypoplasia
#8
Svetlana Vakkilainen, Riikka Mäkitie, Paula Klemetti, Helena Valta, Mervi Taskinen, Eystein Sverre Husebye, Outi Mäkitie
Background: Mutations in RMRP , encoding a non-coding RNA molecule, underlie cartilage-hair hypoplasia (CHH), a syndromic immunodeficiency with multiple pathogenetic mechanisms and variable phenotype. Allergy and asthma have been reported in the CHH population and some patients suffer from autoimmune (AI) diseases. Objective: We explored AI and allergic manifestations in a large cohort of Finnish patients with CHH and correlated clinical features with laboratory parameters and autoantibodies. Methods: We collected clinical and laboratory data from patient interviews and hospital records...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30402091/-helicobacter-pylori-eradication-in-idiopathic-thrombocytopenic-purpura-a-meta-analysis-of-randomized-trials
#9
REVIEW
Bum Jun Kim, Hyeong Su Kim, Hyun Joo Jang, Jung Han Kim
Objective: Several recent reviews of published studies have shown that the eradication of H. pylori infection in patients with ITP improved thrombocytopenia in about half of the cases. However, most included studies were observational case series. We performed the first meta-analysis of randomized trials to gain a better insight into the effect of H. pylori eradication in ITP patients. Methods: A systematic computerized search of the electronic databases including PubMed, EMBASE, Google Scholar, and Cochrane Library (up to December 2017) was conducted...
2018: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/30352001/effectiveness-of-haemophilus-influenzae-type-b-vaccination-after-splenectomy-impact-on-selected-immunological-parameters
#10
Ewelina Grywalska, Dorota Siwicka-Gieroba, Michał Mielnik, Martyna Podgajna, Krzysztof Gosik, Wojciech Dąbrowski, Jacek Roliński
Splenectomy is a surgery indicated in case of splenic rupture after injury, when there are tumors in the spleen, or as a treatment for certain diseases, such as idiopathic thrombocytopenic purpura and spherocytosis. The aims of the study were to assess the immunological response to the Haemophilus influenzae type b (Hib) vaccine and the post-vaccination changes in lymphocyte subsets and cell activation markers in splenectomized patients and healthy volunteers. Blood samples were collected from 25 patients that had undergone splenectomy and from 15 healthy, non-splenectomized volunteers...
October 23, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/30349881/a-comprehensive-targeted-next-generation-sequencing-panel-for-genetic-diagnosis-of-patients-with-suspected-inherited-thrombocytopenia
#11
Ben Johnson, Rachel Doak, David Allsup, Emma Astwood, Gillian Evans, Charlotte Grimley, Beki James, Bethan Myers, Simone Stokley, Jecko Thachil, Jonathan Wilde, Mike Williams, Mike Makris, Gillian C Lowe, Yvonne Wallis, Martina E Daly, Neil V Morgan
Background: Inherited thrombocytopenias (ITs) are a heterogeneous group of disorders characterized by low platelet counts and often disproportionate bleeding with over 30 genes currently implicated. Previously the UK-GAPP study using whole exome sequencing (WES) identified a pathogenic variant in 19 of 47 (40%) patients of which 71% had variants in genes known to cause IT. Aims: To employ a targeted next-generation sequencing platform to improve efficiency of diagnostic testing and reduce overall costs...
October 2018: Research and Practice in Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/30321453/clinical-presentation-in-thrombotic-thrombocytopenic-purpura-real-world-data-from-two-mexican-institutions
#12
Emmanuel Bugarin-Estrada, Andrés Gómez-De León, Yadith Karina López-García, Erik Alejandro Díaz-Chuc, José Manuel Priesca-Marín, Guillermo J Ruiz-Argüelles, José Carlos Jaime-Pérez, David Gómez-Almaguer
BACKGROUND: Thrombotic thrombocytopenic purpura (TTP) is a hematologic disease that can be fatal if not treated early. We aimed to describe the clinical characteristics of Mexican patients with idiopathic TTP. STUDY DESIGN AND METHODS: We conducted a retrospective study, including all adult patients diagnosed with idiopathic TTP from 2011 to 2017 in two Mexican centers. We further compared our results with the published literature. RESULTS: Twenty patients were included; 70% were female, with a median age of 38...
October 15, 2018: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/30288473/autoimmune-hepatitis-during-ledipasvir-sofosbuvir-treatment-of-hepatitis-c-a-case-report
#13
Giovanni Covini, Elena Bredi, Salvatore Badalamenti, Massimo Roncalli, Alessio Aghemo, Massimo Colombo
We report the case of a woman with chronic hepatitis C and idiopathic thrombocytopenic purpura (ITP) who developed autoimmune hepatitis (AIH) during antiviral therapy with ledipasvir (LDV)/sofosbuvir (SOF). The onset of acute hepatitis rose two weeks after starting treatment with LDV/SOF when HCV-RNA tested negative, suggesting a link between rapid HCV clearance and de novo autoimmune diseases. Conclusion: This case report proposes new immunologic scenarios in patients with hepatitis C virus (HCV) with laboratory or clinical signs of autoimmunity during direct-acting antiviral (DAA) therapy...
October 2018: Hepatology Communications
https://www.readbyqxmd.com/read/30256778/distinguishing-autoimmune-myelofibrosis-from-primary-myelofibrosis
#14
REVIEW
Bridget Marcellino, Siraj M El Jamal, John O Mascarenhas
Bone marrow fibrosis (BMF) is a histologic finding in a wide range of diseases, including malignancies, endocrine disorders, autoimmune diseases, and infections. Autoimmune myelofibrosis (AIMF) is an uncommon etiology of BMF; it can be secondary to a defined autoimmune disease, or it can be primary in the absence of a clinically diagnosed autoimmune disease but the presence of serologic evidence of autoantibodies. Distinguishing between primary myelofibrosis (PMF) and non-neoplastic AIMF is of the utmost importance because the prognosis and therapeutic options are different...
September 2018: Clinical Advances in Hematology & Oncology: H&O
https://www.readbyqxmd.com/read/30250741/the-impact-of-helicobacter-pylori-eradication-on-platelet-counts-of-adult-patients-with-idiopathic-thrombocytopenic-purpura
#15
Sara Aljarad, Ahmad Alhamid, Ahmad Sankari Tarabishi, Ameen Suliman, Ziad Aljarad
Background: Idiopathic (immune) thrombocytopenic purpura (ITP) is an acquired disorder characterized by autoantibodies against platelet membrane antigens. Several studies found an association between Helicobacter Pylori infection and the incidence of ITP. So far, It is still unclear whether H. pylori eradication will increase platelet counts in adult ITP patients. We conduct this study to investigate platelet recovery in ITP patients after H. pylori eradication. Methods: This is a prospective study...
2018: BMC Hematology
https://www.readbyqxmd.com/read/30223886/acquired-thrombotic-thrombocytopenia-purpura-associated-with-severe-adamts13-deficiency-in-a-3-year-old-boy-a-case-report-and-review-of-the-literature
#16
Hamidah Alias, Woon Lee Yong, Farah Azima Abdul Muttlib, Ho Wai Koo, C-Khai Loh, Sie Chong Doris Lau, Hafiza Alauddin, Raja Zahratul Azma
BACKGROUND: Acquired thrombotic thrombocytopenia purpura is very rarely encountered in children. It is often misdiagnosed initially when the condition is not inherited. CASE PRESENTATION: We describe a 3-year-old Malay boy who presented with simple febrile seizure and had no neurological deficit, however, he was found to have microangiopathic hemolytic anemia, thrombocytopenia, and elevated serum lactate dehydrogenase. An ADAMTS13 assay results showed zero activities (0%), and markedly high level of ADAMTS13 inhibitor (93...
September 17, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/30213467/disseminated-herpes-simplex-virus-and-varicella-zoster-virus-co-infection-in-a-patient-with-idiopathic-thrombocytopenic-purpura
#17
Christina Bergqvist, Yasmin Abi Aad, Dany Nassar, Saeed El Zein, Souha S Kanj
Concomitant disseminated herpes simplex virus (HSV) and varicella zoster virus (VZV) infection is a rare event. We describe a case of disseminated HSV and VZV infection in an 80-year-old patient many years after splenectomy for idiopathic thrombocytopenic purpura (ITP). This is the first case of disseminated HSV-1 and VZV infection with molecular evidence of the simultaneous presence of both viruses in two different body sites (the skin and cerebrospinal fluid). This adds to the three reports of patients developing cutaneous disseminated herpes zoster multiple years after splenectomy for ITP...
September 10, 2018: Journal of Infection and Public Health
https://www.readbyqxmd.com/read/30172727/fatal-overwhelming-postsplenectomy-infection-due-to-streptococcus-pneumoniae-serotype-10a-with-atypical-polysaccharide-capsule-in-a-patient-with-chromosome-22q11-2-deletion-syndrome-a-case-report
#18
Keiko Matsuoka, Itaru Yanagihara, Yukiko Kawazu, Maho Sato, Masahiro Nakayama, Yukiko Nakura, Nao Kanagawa, Yukihiro Akeda, Futoshi Fujiwara, Kazutoshi Itoh, Hiroaki Kawata, Makoto Takeuchi
We report the first case of a teenage patient with chromosome 22q11.2 deletion syndrome who died of overwhelming postsplenectomy infection (OPSI) by Streptococcus pneumoniae despite appropriate prevention by pneumococcal vaccine. He had congenital heart disease and underwent several surgeries. Immunodeficiency had not been noticed clinically. Two years prior to death, splenectomy was performed for a drug-resistant idiopathic thrombocytopenic purpura and he was immunized with 23-valent pneumococcal polysaccharide vaccine (PPV23) 4 months after splenectomy...
August 29, 2018: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/30157866/h-pylori-infection-and-extra-gastroduodenal-diseases
#19
REVIEW
Feng-Woei Tsay, Ping-I Hsu
Helicobacter pylori infection is the principal cause of peptic ulcer disease, gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue lymphoma. Recent studies have shown that it may interfere with many biological processes and determine or influence the occurrence of many diseases outside the stomach. Currently, the role of H. pylori in idiopathic thrombocytopenic purpura and iron deficiency anemia is well documented. Emerging evidence suggests that it may also contribute to vitamin B12 deficiency, insulin resistance, metabolic syndrome, diabetes mellitus and non-alcoholic liver disease...
August 29, 2018: Journal of Biomedical Science
https://www.readbyqxmd.com/read/30079452/gullain-barr%C3%A3-syndrome-following-off-pump-coronary-artery-bypass-grafting
#20
Vikas Kumar, Deepak Puri, Sunder Negi, Sushil K Rahi, Devant Goswami
We report a case of Gullain-Barré syndrome after off-pump coronary artery bypass grafting surgery in a diabetic male with idiopathic thrombocytopenic purpura who recovered fully after treatment with intravenous immunoglobulin without any residual weakness.
September 2018: Journal of Cardiac Surgery
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