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Glia nanomaterials

I-Lun Hsiao, Yi-Kong Hsieh, Chun-Yu Chuang, Chu-Fang Wang, Yuh-Jeen Huang
Silver nanoparticles (AgNPs) are commonly used nanomaterials in consumer products. Previous studies focused on its effects on neurons; however, little is known about their effects and uptake mechanisms on glial cells under normal or activated states. Here, ALT astrocyte-like, BV-2 microglia and differentiated N2a neuroblastoma cells were directly or indirectly exposed to 10 nm AgNPs using mono- and co-culture system. A lipopolysaccharide (LPS) was pretreated to activate glial cells before AgNP treatment for mimicking NP exposure under brain inflammation...
June 2017: Environmental Toxicology
Çağla Defteralı, Raquel Verdejo, Shahid Majeed, Adriana Boschetti-de-Fierro, Héctor R Méndez-Gómez, Eva Díaz-Guerra, Daniel Fierro, Kristian Buhr, Clarissa Abetz, Ricardo Martínez-Murillo, Daniela Vuluga, Michaël Alexandre, Jean-Michel Thomassin, Christophe Detrembleur, Christine Jérôme, Volker Abetz, Miguel Ángel López-Manchado, Carlos Vicario-Abejón
Graphene, graphene-based nanomaterials (GBNs), and carbon nanotubes (CNTs) are being investigated as potential substrates for the growth of neural cells. However, in most in vitro studies, the cells were seeded on these materials coated with various proteins implying that the observed effects on the cells could not solely be attributed to the GBN and CNT properties. Here, we studied the biocompatibility of uncoated thermally reduced graphene (TRG) and poly(vinylidene fluoride) (PVDF) membranes loaded with multi-walled CNTs (MWCNTs) using neural stem cells isolated from the adult mouse olfactory bulb (termed aOBSCs)...
2016: Frontiers in Bioengineering and Biotechnology
A N Koppes, K W Keating, A L McGregor, R A Koppes, K R Kearns, A M Ziemba, C A McKay, J M Zuidema, C J Rivet, R J Gilbert, D M Thompson
UNLABELLED: The use of exogenous electrical stimulation to promote nerve regeneration has achieved only limited success. Conditions impeding optimized outgrowth may arise from inadequate stimulus presentation due to differences in injury geometry or signal attenuation. Implantation of an electrically-conductive biomaterial may mitigate this attenuation and provide a more reproducible signal. In this study, a conductive nanofiller (single-walled carbon nanotubes [SWCNT]) was selected as one possible material to manipulate the bulk electrical properties of a collagen type I-10% Matrigel™ composite hydrogel...
July 15, 2016: Acta Biomaterialia
Cyrill Bussy, Khuloud T Al-Jamal, Jorge Boczkowski, Sophie Lanone, Maurizio Prato, Alberto Bianco, Kostas Kostarelos
Surface tunability and their ability to translocate plasma membranes make chemically functionalized carbon nanotubes (f-CNTs) promising intracellular delivery systems for therapeutic or diagnostic purposes in the central nervous system (CNS). The present study aimed to determine the biological impact of different types of multiwalled CNTs (MWNTs) on primary neuronal and glial cell populations isolated from fetal rat frontal cortex (FCO) and striatum (ST). Neurons from both brain regions were generally not affected by exposure to MWNTs as determined by a modified LDH assay...
August 25, 2015: ACS Nano
Sergio Anguissola, David Garry, Anna Salvati, Peter J O'Brien, Kenneth A Dawson
The fast-paced development of nanotechnology needs the support of effective safety testing. We have developed a screening platform measuring simultaneously several cellular parameters for exposure to various concentrations of nanoparticles (NPs). Cell lines representative of different organ cell types, including lung, endothelium, liver, kidney, macrophages, glia, and neuronal cells were exposed to 50 nm amine-modified polystyrene (PS-NH2) NPs previously reported to induce apoptosis and to 50 nm sulphonated and carboxyl-modified polystyrene NPs that were reported to be silent...
2014: PloS One
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