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Glia nanomaterials

A N Koppes, K W Keating, A L McGregor, R A Koppes, K R Kearns, A M Ziemba, C A McKay, J M Zuidema, C J Rivet, R J Gilbert, D M Thompson
UNLABELLED: The use of exogenous electrical stimulation to promote nerve regeneration has achieved only limited success. Conditions impeding optimized outgrowth may arise from inadequate stimulus presentation due to differences in injury geometry or signal attenuation. Implantation of an electrically-conductive biomaterial may mitigate this attenuation and provide a more reproducible signal. In this study, a conductive nanofiller (single-walled carbon nanotubes [SWCNT]) was selected as one possible material to manipulate the bulk electrical properties of a collagen type I-10% Matrigelâ„¢ composite hydrogel...
July 15, 2016: Acta Biomaterialia
Cyrill Bussy, Khuloud T Al-Jamal, Jorge Boczkowski, Sophie Lanone, Maurizio Prato, Alberto Bianco, Kostas Kostarelos
Surface tunability and their ability to translocate plasma membranes make chemically functionalized carbon nanotubes (f-CNTs) promising intracellular delivery systems for therapeutic or diagnostic purposes in the central nervous system (CNS). The present study aimed to determine the biological impact of different types of multiwalled CNTs (MWNTs) on primary neuronal and glial cell populations isolated from fetal rat frontal cortex (FCO) and striatum (ST). Neurons from both brain regions were generally not affected by exposure to MWNTs as determined by a modified LDH assay...
August 25, 2015: ACS Nano
Sergio Anguissola, David Garry, Anna Salvati, Peter J O'Brien, Kenneth A Dawson
The fast-paced development of nanotechnology needs the support of effective safety testing. We have developed a screening platform measuring simultaneously several cellular parameters for exposure to various concentrations of nanoparticles (NPs). Cell lines representative of different organ cell types, including lung, endothelium, liver, kidney, macrophages, glia, and neuronal cells were exposed to 50 nm amine-modified polystyrene (PS-NH2) NPs previously reported to induce apoptosis and to 50 nm sulphonated and carboxyl-modified polystyrene NPs that were reported to be silent...
2014: PloS One
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