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Axial Spondylarthropathy

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https://www.readbyqxmd.com/read/30389692/low-incidence-of-vertebral-fractures-in-early-spondyloarthritis-5-year-prospective-data-of-the-desir-cohort
#1
Julie Sahuguet, Jacques Fechtenbaum, Anna Molto, Adrien Etcheto, Clementina López-Medina, Pascal Richette, Maxime Dougados, Christian Roux, Karine Briot
OBJECTIVES: An increased risk of vertebral fractures (VFs) has been reported in spondyloarthritis (SpA). Our hypothesis is that the prevalence of VFs is lower than reported in previous studies, especially in early SpA. This study aimed at assessing the incidence of radiographical VFs over 5 years in early axial SpA. METHODS: The DESIR (DEvenir des Spondylarthropathies Indifférenciées Récentes) cohort, which included patients with inflammatory back pain highly suggestive of axial SpA, is the basis of this study...
November 2, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/30167327/can-power-doppler-ultrasound-of-the-entheses-help-in-classifying-recent-axial-spondyloarthritis-data-from-the-desir-cohort
#2
Cecile Poulain, Maria Antonietta D'Agostino, Severine Thibault, Jean Pierre Daures, Salah Ferkal, Philippe Le Corvoisier, Alain Rahmouni, Damien Loeuille, Maxime Dougados, Pascal Claudepierre
Early diagnosis of axial spondyloarthritis (axSpA) remains a challenge due to the lack of specificity of clinical symptoms and variable prevalence of axial imaging findings permitting a definite diagnosis. Power Doppler ultrasonography (PDUS) of the entheses has demonstrated to be a potential useful tool for the classification and diagnostic management of early SpA independently of the phenotype. Objectives: To assess the classification value (sensitivity and specificity) of PDUS-defined enthesitis for identifying patients fulfilling Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axSpA (ASAS+) in patients with recent inflammatory back pain (IBP) (the DESIR (DEvenir des Spondylarthropathies Indifférenciées Récentes) cohort)...
2018: RMD Open
https://www.readbyqxmd.com/read/28668809/adherence-to-antitumor-necrosis-factor-use-recommendations-in-spondyloarthritis-measurement-and-effect-in-the-desir-cohort
#3
Stephanie Harvard, Daphne Guh, Nick Bansback, Pascal Richette, Alain Saraux, Bruno Fautrel, Aslam H Anis
OBJECTIVE: To evaluate a classification system to define adherence to axial spondyloarthritis (axSpA) anti-tumor necrosis factor (anti-TNF) use recommendations and examine the effect of adherence on outcomes in the DESIR cohort (Devenir des Spondylarthropathies Indifférenciées Récentes). METHODS: Using alternate definitions of adherence, patients were classified as adherent "timely" anti-TNF users, nonadherent "late" anti-TNF users, adherent nonusers ("no anti-TNF need"), non-adherent nonusers ("unmet anti-TNF need")...
October 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28663306/the-yield-of-a-positive-mri-of-the-spine-as-imaging-criterion-in-the-asas-classification-criteria-for-axial-spondyloarthritis-results-from-the-space-and-desir-cohorts
#4
Zineb Ez-Zaitouni, Pauline Ac Bakker, Miranda van Lunteren, Manouk de Hooge, Rosaline van den Berg, Monique Reijnierse, Karen Minde Fagerli, Robert Bm Landewé, Roberta Ramonda, Lennart Th Jacobsson, Alain Saraux, Gregory Lenczner, Antoine Feydy, Jean Baptiste Pialat, Fabrice Thévenin, Floris A van Gaalen, Désirée van der Heijde
OBJECTIVES: To assess the prevalence of spinal inflammation on MRI in patients with chronic back pain (CBP) of maximally 3 years duration and to evaluate the yield of adding a positive MRI-spine as imaging criterion to the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axial spondyloarthritis (axSpA). METHODS: Baseline imaging of the sacroiliac joints (X-SI), MRI of the sacroiliac joints (MRI-SI) and MRI-spine were scored by ≥2 experienced central readers per modality in the SPondyloArthritis Caught Early (SPACE) and DEvenir des Spondylarthropathies Indifférenciées Récentes (DESIR) cohorts...
October 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28473425/a-nationwide-non-medical-switch-from-originator-infliximab-to-biosimilar-ct-p13-in-802-patients-with-inflammatory-arthritis-1-year-clinical-outcomes-from-the-danbio-registry
#5
Bente Glintborg, Inge Juul Sørensen, Anne Gitte Loft, Hanne Lindegaard, Asta Linauskas, Oliver Hendricks, Inger Marie Jensen Hansen, Dorte Vendelbo Jensen, Natalia Manilo, Jakob Espesen, Mette Klarlund, Jolanta Grydehøj, Sabine Sparre Dieperink, Salome Kristensen, Jimmi Sloth Olsen, Henrik Nordin, Stavros Chrysidis, Dorte Dalsgaard Pedersen, Michael Veedfald Sørensen, Lis Smedegaard Andersen, Kathrine Lederballe Grøn, Niels Steen Krogh, Lars Pedersen, Merete Lund Hetland
OBJECTIVES: According to guidelines, a nationwide non-medical switch from originator (INX, Remicade) to biosimilar infliximab (Remsima, CT-P13) was conducted in Danish patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (AxSpA). We investigated disease activity before/after switching and retention rates in the DANBIO registry. METHODS: Disease activities 3 months before and after switch and changes over time were calculated...
August 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28351491/vegf-inhibition-as-possible-therapy-in-spondyloarthritis-patients-targeting-bone-remodelling
#6
Alexis Lacout, Robert Yves Carlier, Mostafa El Hajjam, Pierre Yves Marcy
Spondyloarthritis refers to a group of chronic inflammatory rheumatic diseases that predominantly affects the axial skeleton, causing pain and stiffness. Human bone is highly dynamic organ that interacts with a wide array cells and tissues. Process of bone remodelling relies on a delicate balance between bone formation and bone resorption, orchestrated by osteoblasts and osteoclasts. Disruption of this homeostatic balance of bone removal and replacement can manifest as inappropriate new bone formation found in spondylarthritis...
April 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/28283515/comparison-of-mri-with-radiography-for-detecting-structural-lesions-of-the-sacroiliac-joint-using-ct-as-standard-of-reference-results-from-the-simact-study
#7
COMPARATIVE STUDY
Torsten Diekhoff, Kay-Geert A Hermann, Juliane Greese, Carsten Schwenke, Denis Poddubnyy, Bernd Hamm, Joachim Sieper
OBJECTIVE: Radiographs of sacroiliac (SI) joints are used for the detection of structural damage in patients with axial spondyloarthritis (axSpA), but are often difficult to interpret. Here, we address the question how the T1-weighted MRI (T1w MRI) sequence compares with radiography for SI joints' structural lesions using low-dose CT as the standard of reference. METHODS: Radiographs, T1w MRI and low-dose CT of the SI joints from 110 patients (mean age 36.1 (19-57) years, 52% males and 48% females; 53% with axSpA, 21 non-radiographic axSpA and 32% radiographic axSpA, 47% with non-SpA) referred to the rheumatologist because of unclear chronic back pain, but possible axSpA, were scored for structural lesions (erosions, sclerosis, joint space changes and an overall impression of positivity)...
September 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28240589/fatigue-contributes-to-work-productivity-impairment-in-patients-with-axial-spondyloarthritis-a-cross-sectional-uk-study
#8
Shima Espahbodi, Paul Bassett, Charlotte Cavill, Mandy Freeth, John Hole, Raj Sengupta
OBJECTIVES: To determine factors associated with absenteeism, presenteeism, work productivity loss (WPL), and daily activity impairment in UK patients with AxSpA using standardised measures. METHODS: 490 patients with AxSpA completed (1) Work Productivity and Impairment questionnaire (WPAI), providing measures for absenteeism, presenteeism, WPL and daily activity impairment, and (2) BASDAI, BASFI, BASMI, Jenkins Sleep scale, Patient Global Assessment disease activity (PGA), back pain night and anytime, EQ-5D for mobility, self-care, daily activities, pain/discomfort, anxiety/depression, EQ-VAS Health State Today, FACIT fatigue, for health-related disease factors...
July 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28240587/evaluation-of-whether-extremely-high-enthesitis-or-bath-ankylosing-spondylitis-disease-activity-index-basdai-scores-suggest-fibromyalgia-and-confound-the-anti-tnf-response-in-early-non-radiographic-axial-spondyloarthritis
#9
Maxime Dougados, Isabelle Logeart, Annette Szumski, Javier Coindreau, Heather Jones
OBJECTIVES: Differentiating between pain from spondyloarthritis (SpA) and pain from fibromyalgia is challenging. We evaluated patients with non-radiographic axial SpA (nr-axSpA) to determine the percentage of patients with extremely high enthesitis and/or Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) scores, the relationship between extreme scores and depression, and the effect of extreme scores on treatment outcomes with etanercept. METHODS: Patients with nr-axSpA received double-blind etanercept 50 mg or placebo weekly and were divided into those who did vs did not have extreme scores at baseline...
May 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28240584/type-i-and-iii-collagen-turnover-is-increased-in-axial-spondyloarthritis-and-psoriatic-arthritis-associations-with-disease-activity-and-diagnostic-capacity
#10
Natasja Stæhr Gudmann, Anne Sofie Siebuhr, Anne Friesgaard Christensen, Leif Ejstrup, Grith Lykke Sørensen, Anne Gitte Loft, Morten Asser Karsdal, Anne-Christine Bay-Jensen, Heidi Lausten Munk, Peter Junker
OBJECTIVES: To investigate the turnover of type I and III collagen by neo-epitope markers in patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA). METHODS: Patients with PsA (n=101) or axSpA (n=110) and healthy subjects (n=120) were included. Demographic and clinical data were recorded. Markers of type I and III collagen were quantified by RIA (ICTP) or ELISA (C1M and C3M). Non-parametric statistics were applied for intergroup comparisons and correlation studies...
July 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28214597/classification-criteria-versus-physician-s-opinion-for-considering-a-patient-with-inflammatory-back-pain-as-suffering-from-spondyloarthritis
#11
Pierre Gazeau, Divi Cornec, Marie Agnes Timsit, Maxime Dougados, Alain Saraux
OBJECTIVE: To assess agreement among methods for classifying patients with inflammatory back pain (IBP) after a 2-year follow-up. METHODS: Patients with IBP in the French nationwide, longitudinal, prospective cohort DESIR were classified after 2years based on imaging findings, rheumatologist's confidence in a diagnosis of spondyloarthritis, three classification criteria sets (axial Assessment of Spondyloarthritis international Society [ASAS], European Spondylarthropathy Study Group [ESSG], and Amor) and treatment (TNFα antagonists)...
January 2018: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/28179264/performance-of-the-asas-classification-criteria-for-axial-and-peripheral-spondyloarthritis-a-systematic-literature-review-and-meta-analysis
#12
REVIEW
Alexandre Sepriano, Roxana Rubio, Sofia Ramiro, Robert Landewé, Désirée van der Heijde
OBJECTIVE: To summarise the evidence on the performance of the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axial spondyloarthritis (axSpA) (also imaging and clinical arm separately), peripheral (p)SpA and the entire set, when tested against the rheumatologist's diagnosis ('reference standard'). METHODS: A systematic literature review was performed to identify eligible studies. Raw data on SpA diagnosis and classification were extracted or, if necessary, obtained from the authors of the selected publications...
May 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28062405/presence-of-multiple-spondyloarthritis-spa-features-is-important-but-not-sufficient-for-a-diagnosis-of-axial-spondyloarthritis-data-from-the-spondyloarthritis-caught-early-space-cohort
#13
Z Ez-Zaitouni, P A C Bakker, M van Lunteren, I J Berg, R Landewé, M van Oosterhout, M Lorenzin, D van der Heijde, F A van Gaalen
OBJECTIVES: Concerns have been raised about overdiagnosis of axial spondyloarthritis (axSpA). We investigated whether patients with chronic back pain (CBP) of short duration and multiple SpA features are always diagnosed with axSpA by the rheumatologist, and to what extent fulfilment of the Assessment of SpondyloArthritis International Society (ASAS) axSpA criteria is associated with an axSpA diagnosis. METHODS: Baseline data from 500 patients from the SPondyloArthritis Caught Early cohort which includes patients with CBP (≥3 months, ≤2 years, onset <45 years) were analysed...
June 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28035438/should-axial-spondyloarthritis-without-radiographic-changes-be-treated-with-anti-tnf-agents
#14
REVIEW
Andrew Keat, Alexander N Bennett, Karl Gaffney, Helena Marzo-Ortega, Raj Sengupta, Tamara Everiss
A spectrum of disease extends beyond the rigid confines of ankylosing spondylitis (AS). Axial spondyloarthritis (axSpA) encompasses non-radiographic axSpA (nr-axSpA) in individuals without established radiographic changes but with other clinical/imaging axSpA features and AS in those with definite sacroiliac joint changes on pelvic X-rays. A broad consensus about the management of nr-axSpA is emerging among clinicians, but the evidence base remains open to question. To explore whether nr-axSpA and AS should be treated similarly, we examined the literature on their prevalence, natural history, disease burden, and treatment...
March 2017: Rheumatology International
https://www.readbyqxmd.com/read/27888172/disease-activity-trajectories-in-early-axial-spondyloarthritis-results-from-the-desir-cohort
#15
MULTICENTER STUDY
Anna Molto, Sophie Tezenas du Montcel, Daniel Wendling, Maxime Dougados, Antoine Vanier, Laure Gossec
BACKGROUND: Disease activity may change over time in axial spondyloarthritis (axSpA). The objectives were to identify patterns of disease activity evolution in patients with early axSpA. METHODS: Patients from the prospective early axSpA cohort (DEvenir des Spondyloarthrites Indifférenciées Récentes (DESIR)) who fulfilled the Assessment in SpondyloArthritis Society (ASAS) criteria for axSpA at baseline and with at least three Ankylosing Spondylitis Disease Activity Score (ASDAS) values available over the 3 years of follow-up were analysed...
June 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27856659/new-treatment-targets-for-axial-spondyloarthritis
#16
REVIEW
Joachim Sieper
Axial spondyloarthritis (axSpA) patients can be divided into those with structural damage in the SI joint visible on X-rays, termed radiographic axSpA or AS, and those in an earlier phase of the disease, without structural damage in the SI joint, termed non-radiographic axSpA. TNF-blockers have been shown to be highly effective in the treatment of active axSpA. Interestingly, conventional DMARDs and also non-TNF-blocker biologics targeting IL-1, IL-6 and T cells (abatacept) are not effective. Recent interest has focused on the cytokines IL-23 and IL-17 as potential treatment targets in axSpA...
December 2016: Rheumatology
https://www.readbyqxmd.com/read/27486525/responsiveness-of-a-simple-rapid-3-like-index-compared-to-disease-specific-basdai-and-asdas-indices-in-patients-with-axial-spondyloarthritis
#17
Isabel Castrejón, Theodore Pincus, Daniel Wendling, Maxime Dougados
OBJECTIVE: To evaluate the responsiveness of a simple routine assessment of patient index data (RAPID3)-like index that includes only 3 patient self-report measures (physical function, pain and patient global estimate) compared to that of traditional composite indices to assess change in patients with axial spondyloarthritis (Ax-SpA). METHODS: Devenir des Spondylarthropathies Indifférenciées Récentes (DESIR) is a prospective cohort of patients with inflammatory back pain suggestive of Ax-SpA...
2016: RMD Open
https://www.readbyqxmd.com/read/27214232/clinical-and-imaging-signs-of-spondyloarthritis-in-first-degree-relatives-of-hla-b27-positive-ankylosing-spondylitis-patients-the-pre-spondyloarthritis-pre-spa-cohort-study
#18
Maureen C Turina, Janneke J de Winter, Jacky E Paramarta, Mihaela Gamala, Nataliya Yeremenko, Marita N Nabibux, Robert Landewé, Dominique L Baeten
OBJECTIVE: To investigate whether seemingly healthy first-degree relatives of patients with ankylosing spondylitis (AS) have clinical, laboratory, or imaging features of spondyloarthritis (SpA). METHODS: First-degree relatives (ages 18-40 years) of HLA-B27-positive AS patients were included in the pre-spondyloarthritis (Pre-SpA) cohort, a prospective inception cohort study. Clinical, biologic, and imaging features were recorded. First-degree relatives were classified according to several sets of SpA classification criteria...
October 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/26968522/biologic-agents-in-juvenile-spondyloarthropathies
#19
REVIEW
María Martha Katsicas, Ricardo Russo
The juvenile spondyloarthropathies (JSpA) are a group of related rheumatic diseases characterized by involvement of peripheral large joints, axial joints, and entheses (enthesitis) that begin in the early years of life (prior to 16(th) birthday).The nomenclature and concept of spondyloarthropathies has changed during the last few decades. Although there is not any specific classification of JSpA, diseases under the spondyloarthropathy nomenclature umbrella in the younger patients include: the seronegative enthesitis and arthropathy (SEA) syndrome, juvenile ankylosing spondylitis, reactive arthritis, and inflammatory bowel disease-associated arthritis...
March 12, 2016: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/26875714/-presence-of-subclinical-inflammation-in-axial-spondyloarthropathy-patients-in-clinical-remission
#20
Ying Wu, Shengqian Xu, Shan Qi, Weng Liu, Jing Cai, Jianhua Xu
OBJECTIVE: To investigate the incidence of bone marrow edema in sacroiliac joint under examination of magnetic resonance imaging (MRI) in patients with axial spondyloarthropathy (SpA) in remission. METHODS: A total of 87 patients with axial SpA were recruited. Disease activity was assessed by calculation of BASDAI and ASDAScrp scores. All the SpA patients completed MRI scan of sacroiliac joint and bone marrow edema in sacroiliac joint was quantized by SPARCC scoring standard...
February 2, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
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