keyword
https://read.qxmd.com/read/38359943/factors-associated-with-treatment-pathways-in-early-axial-spondyloarthritis-a-multistate-analysis-of-the-10-year-follow-up-of-the-desir-cohort
#1
JOURNAL ARTICLE
Elodie Portier, Sylvie Chevret, Anouk Walter-Petrich, Adeline Ruyssen-Witrand, Maxime Dougados, Anna Moltó
OBJECTIVE: Current recommendations for the management of patients with axial spondyloarthritis (axSpA) emphasize the need of an individualized strategy in therapeutic decision-making. The study objectives were to describe therapeutic strategies observed in axSpA, and to assess the factors associated with treatment intensification over time. METHODS: We included patients with axSpA from the French prospective cohort DESIR (Devenir des Spondylarthropathies Indifférenciées Récentes), with a scheduled 10-year follow-up...
February 15, 2024: Journal of Rheumatology
https://read.qxmd.com/read/38123481/impact-of-disease-outcomes-on-the-assessment-of-spondyloarthritis-international-society-health-index-asas-hi-a-bayesian-network-analysis-of-the-desir-cohort
#2
JOURNAL ARTICLE
Imke Redeker, Robert Landewé, Désirée van der Heijde, Sofia Ramiro, Annelies Boonen, Maxime Dougados, Jürgen Braun, Uta Kiltz
OBJECTIVE: The objective of this study is to build a structural model visualising and quantifying the interrelationships of different disease outcomes with the Assessment of SpondyloArthritis International Society Health Index (ASAS HI) in patients with axial spondyloarthritis (axSpA). METHODS: Cross-sectional data collected at month 72 of the Devenir des Spondylarthropathies Indifferénciées Récentes cohort was analysed. Combining prior knowledge and observed data, probabilistic Bayesian network modelling was used to study how the interplay of different disease outcomes affects the ASAS HI, which measures disease-specific overall functioning and health...
December 20, 2023: RMD Open
https://read.qxmd.com/read/37725129/-nonpharmacological-treatment-measures-rehabilitation-services-and-membership-in-patient-support-groups-in-axial-spondylarthritis-the-attentus-axspa-study
#3
JOURNAL ARTICLE
D Meyer-Olson, K Hoeper, L Hammel, S Lieb, A Haehle, U Kiltz
BACKGROUND: The treatment of axial spondylarthritis (axSpA) includes pharmacological treatment measures (PTM) and nonpharmacological treatment measures (NPTM) as well as supporting resources, such as rehabilitation services (RS) and membership in patient support groups (PSG). Nevertheless, there are significant participation restrictions in patients with axSpA in Germany. OBJECTIVE: Investigation of functional deficits, participation restrictions and utilization of PTM, NPTM, RS and PSG membership in patients with axSpA...
September 19, 2023: Zeitschrift Für Rheumatologie
https://read.qxmd.com/read/35723604/is-the-risk-of-infection-higher-during-treatment-with-secukinumab-than-with-tnf-inhibitors-an-observational-study-from-the-nordic-countries
#4
JOURNAL ARTICLE
Bente Glintborg, Daniela Di Giuseppe, Johan K Wallman, Sella A Provan, Dan Nordström, Anna-Mari Hokkanen, Jenny Österlund, Eirik Kristianslund, Tore K Kvien, Bjorn Gudbjornsson, Merete Lund Hetland, Brigitte Michelsen, Lennart Jacobsson, Johan Askling, Ulf Lindström
OBJECTIVES: The positioning of secukinumab in the treatment of axial SpA (axSpA) and PsA is debated, partly due to a limited understanding of the comparative safety of the available treatments. We aimed to assess the risk of the key safety outcome infections during treatment with secukinumab and TNF inhibitors (TNFi). METHODS: Patients with SpA and PsA starting secukinumab or TNFi year 2015 through 2018 were identified in four Nordic rheumatology registers. The first hospitalized infection during the first year of treatment was identified through linkage to national registers...
February 1, 2023: Rheumatology
https://read.qxmd.com/read/35716180/spondyloarthritis-in-familial-mediterranean-fever-a-cohort-study
#5
JOURNAL ARTICLE
Sevtap Acer Kasman, Mehmet Tuncay Duruöz
Familial Mediterranean fever (FMF) and spondyloarthritis (SpA) may show several common signs. This study aimed to evaluate the frequency of SpA and its manifestations in FMF, the impact of SpA on FMF, and the associations of non-episodic findings (heel enthesitis, protracted arthritis, and sacroiliitis) with the FMF features. Demographic, clinical, imaging, and genetic data were retrieved from medical records of the patients with adult FMF. To identify patients who met the classification criteria for SpA, data including rheumatologic inquiry were recorded...
June 18, 2022: Rheumatology International
https://read.qxmd.com/read/35042728/evaluation-of-long-term-tnfi-effectiveness-after-a-first-switch-in-early-axial-spondyloarthritis-considering-time-varying-prescription-bias-an-inverse-probability-weighting-analysis-of-the-desir-cohort
#6
JOURNAL ARTICLE
Marion Pons, Sylvie Chevret, Karine Briot, Maria-Antonietta d'Agostino, Christian Roux, Maxime Dougados, Anna Molto
OBJECTIVE: To evaluate long-term effectiveness of tumour necrosis factor inhibitor (TNFi) after a first switch, and their associated factors in an early axial spondyloarthritis (axSpA) population, considering time-varying prescription bias. METHODS: Observational prospective cohort (DEvenir des Spondylarthropathies Indifférenciées Récentes) with 5 years of follow-up, including 708 TNFi-naïve patients with early axSpA. Long-term effectiveness of TNFi after a first switch (ASAS40 response after at least 2 visits under treatment) were estimated using marginal structural models (implementing inverse-probability weighting and iterative propensity scores)...
January 2022: RMD Open
https://read.qxmd.com/read/34864896/risk-of-flare-after-tapering-or-withdrawal-of-b-tsdmards-in-patients-with-ra-or-axspa-a-systematic-review-and-meta-analysis
#7
JOURNAL ARTICLE
Line Uhrenholt, Robin Christensen, Wilfred K H Dinesen, Caroline H Liboriussen, Stine S Andersen, Lene Dreyer, Annette Schlemmer, Ellen-Margrethe Hauge, Conni Skrubbeltrang, Peter C Taylor, Salome Kristensen
OBJECTIVE: To evaluate flare risk when tapering or withdrawing biological or targeted synthetic disease-modifying antirheumatic drugs (b-/tsDMARDs) compared to continuation in patients with inflammatory arthritis (IA) in sustained remission or low disease activity. METHODS: Articles were identified in Cochrane Library, PubMed, EMBASE and Web of Science. Eligible trials were randomised, controlled trials comparing tapering and/or withdrawal of b- and/or tsDMARDs with standard dose in IA...
December 3, 2021: Rheumatology
https://read.qxmd.com/read/34733383/-ankylosing-spondylitis-in-senegal-epidemiological-diagnostic-therapeutic-and-evolutionary-features-at-the-hospital-center-university-aristide-le-dantec-dakar
#8
JOURNAL ARTICLE
Abbasse Abba, Moustapha Niasse, Ladji Mohamed Diaby, Hassan Ali
Introduction: ankylosing spondylitis (AS) is a progressive disease, which can result in disability. The purpose of this study is to describe the epidemiological, diagnostic, therapeutic and evolutionary features of AS in the Department of Rheumatology of the Hospital Center University Aristide Le Dantec, Dakar. Methods: we conducted a descriptive and analytical cross-sectional study. Data were collected on a prospective and retrospective basis over a period of 8 years, between January 2012 and December 2020...
2021: Pan African Medical Journal
https://read.qxmd.com/read/34297033/fertility-and-pregnancy-outcomes-in-women-with-spondyloarthritis-a-systematic-review-and-meta-analysis
#9
JOURNAL ARTICLE
Sabrina Hamroun, Aghilès Hamroun, Jean-Joël Bigna, Edem Allado, Frauke Förger, Anna Molto
OBJECTIVE: The aim of this study was to determine the impact of SpA and its treatments on fertility and pregnancy outcomes, as well as the impact of pregnancy on disease activity. METHODS: A systematic review and meta-analyses were performed, including studies in women with SpA [axial (axSpA) and peripheral SpA, including PsA]. The heterogeneity between studies was quantified (I2), and in the case of substantial heterogeneity, the results were reported in a narrative review...
April 11, 2022: Rheumatology
https://read.qxmd.com/read/33207078/long-term-association-between-disease-activity-and-disability-in-early-axial-spondyloarthritis-results-from-the-desir-cohort
#10
JOURNAL ARTICLE
Pedro D Carvalho, Adeline Ruyssen-Witrand, Ana Marreiros, Pedro M Machado
OBJECTIVES: Our primary objective was to study the long-term association between disease activity and disability in axial spondyloarthritis (axSpA). Our secondary objective was to define patient profiles according to their level of disability. METHODS: We analysed data collected during the first five years of follow-up of a large early axSpA cohort - the Devenir des Spondylarthropathies Indifferénciées Récentes (DESIR) cohort. Multivariable models were built to study the association between Ankylosing Spondylitis Health Assessment Questionnaire (HAQ-AS) and Ankylosing Spondylitis Disease Activity Score C-reactive protein (ASDAS-CRP), adjusting for potential confounders...
November 18, 2020: Arthritis Care & Research
https://read.qxmd.com/read/32536262/diagnostic-performance-of-plain-radiography-for-sacroiliitis-in-patients-with-suspected-axial-spondyloarthritis-a-systematic-review-and-meta-analysis
#11
JOURNAL ARTICLE
Youngjune Kim, Choong Guen Chee, Junghoon Kim, Jungheum Cho, Min A Yoon, Hye Won Chung
BACKGROUND: Plain radiography serves a pivotal role in diagnosing axial spondyloarthritis. However, a broad range of diagnostic performance of plain radiography has been reported. PURPOSE: To perform a systematic review and meta-analysis to measure the diagnostic performance of plain radiography for sacroiliitis in patients suspected of having axial spondyloarthritis using magnetic resonance imaging (MRI) findings as the reference standard. MATERIAL AND METHODS: Studies comparing radiography and MRI in the diagnosis of sacroiliitis in patients suspected of having axial spondyloarthritis were searched in PubMed and EMBASE...
April 2021: Acta Radiologica
https://read.qxmd.com/read/31784451/clinical-manifestations-disease-activity-and-disease-burden-of-radiographic-versus-non-radiographic-axial-spondyloarthritis-over-5-years-of-follow-up-in-the-desir-cohort
#12
COMPARATIVE STUDY
Clementina López-Medina, Anna Molto, Pascal Claudepierre, Maxime Dougados
OBJECTIVES: To compare the clinical manifestations, disease activity and disease burden between patients with radiographic (r-axSpA) and non-radiographic axial spondyloarthritis (nr-axSpA) over a 5-year follow-up period in the Devenir des Spondylarthropathies Indifferénciées Récentes (DESIR) cohort. METHODS: Patients from the DESIR cohort who had X-ray images of the sacroiliac joints available at baseline and did not leave the study during the 5-year follow-up period because of a diagnosis other than axSpA were included...
February 2020: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/30873948/evaluation-of-the-predictive-validity-of-the-asas-axial-spondyloarthritis-criteria-in-the-desir-cohort
#13
JOURNAL ARTICLE
Bhowmik Meghnathi, Alain Saraux, Maxime Dougados, Anna Moltó
OBJECTIVES: To evaluate the predictive validity of the Assessment of SpondyloArthritis international Society (ASAS) axial spondyloarthritis (axSpA), Amor, European Spondylarthropathy Study Group (ESSG) and modified New York (mNY) classification criteria. METHODS: Patients from the DESIR cohort (inflammatory back pain suggestive of axSpA for >3 months but <3 years duration), followed for up to 5 years. Positive predictive value (PPV) of the set of criteria collected at baseline (ASAS, and its arms, Amor, ESSG and mNY: fulfilled/not fulfilled) were tested against the rheumatologist's axSpA diagnosis (fulfilled/not fulfilled) after 5 years of follow-up...
September 2019: Clinical and Experimental Rheumatology
https://read.qxmd.com/read/30389692/low-incidence-of-vertebral-fractures-in-early-spondyloarthritis-5-year-prospective-data-of-the-desir-cohort
#14
JOURNAL ARTICLE
Julie Sahuguet, Jacques Fechtenbaum, Anna Molto, Adrien Etcheto, Clementina López-Medina, Pascal Richette, Maxime Dougados, Christian Roux, Karine Briot
OBJECTIVES: An increased risk of vertebral fractures (VFs) has been reported in spondyloarthritis (SpA). Our hypothesis is that the prevalence of VFs is lower than reported in previous studies, especially in early SpA. This study aimed at assessing the incidence of radiographical VFs over 5 years in early axial SpA. METHODS: The DESIR (DEvenir des Spondylarthropathies Indifférenciées Récentes) cohort, which included patients with inflammatory back pain highly suggestive of axial SpA, is the basis of this study...
January 2019: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/30167327/can-power-doppler-ultrasound-of-the-entheses-help-in-classifying-recent-axial-spondyloarthritis-data-from-the-desir-cohort
#15
JOURNAL ARTICLE
Cecile Poulain, Maria Antonietta D'Agostino, Severine Thibault, Jean Pierre Daures, Salah Ferkal, Philippe Le Corvoisier, Alain Rahmouni, Damien Loeuille, Maxime Dougados, Pascal Claudepierre
Early diagnosis of axial spondyloarthritis (axSpA) remains a challenge due to the lack of specificity of clinical symptoms and variable prevalence of axial imaging findings permitting a definite diagnosis. Power Doppler ultrasonography (PDUS) of the entheses has demonstrated to be a potential useful tool for the classification and diagnostic management of early SpA independently of the phenotype. OBJECTIVES: To assess the classification value (sensitivity and specificity) of PDUS-defined enthesitis for identifying patients fulfilling Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axSpA (ASAS+) in patients with recent inflammatory back pain (IBP) (the DESIR (DEvenir des Spondylarthropathies Indifférenciées Récentes) cohort)...
2018: RMD Open
https://read.qxmd.com/read/28668809/adherence-to-antitumor-necrosis-factor-use-recommendations-in-spondyloarthritis-measurement-and-effect-in-the-desir-cohort
#16
JOURNAL ARTICLE
Stephanie Harvard, Daphne Guh, Nick Bansback, Pascal Richette, Alain Saraux, Bruno Fautrel, Aslam H Anis
OBJECTIVE: To evaluate a classification system to define adherence to axial spondyloarthritis (axSpA) anti-tumor necrosis factor (anti-TNF) use recommendations and examine the effect of adherence on outcomes in the DESIR cohort (Devenir des Spondylarthropathies Indifférenciées Récentes). METHODS: Using alternate definitions of adherence, patients were classified as adherent "timely" anti-TNF users, nonadherent "late" anti-TNF users, adherent nonusers ("no anti-TNF need"), non-adherent nonusers ("unmet anti-TNF need")...
October 2017: Journal of Rheumatology
https://read.qxmd.com/read/28663306/the-yield-of-a-positive-mri-of-the-spine-as-imaging-criterion-in-the-asas-classification-criteria-for-axial-spondyloarthritis-results-from-the-space-and-desir-cohorts
#17
JOURNAL ARTICLE
Zineb Ez-Zaitouni, Pauline Ac Bakker, Miranda van Lunteren, Manouk de Hooge, Rosaline van den Berg, Monique Reijnierse, Karen Minde Fagerli, Robert Bm Landewé, Roberta Ramonda, Lennart Th Jacobsson, Alain Saraux, Gregory Lenczner, Antoine Feydy, Jean Baptiste Pialat, Fabrice Thévenin, Floris A van Gaalen, Désirée van der Heijde
OBJECTIVES: To assess the prevalence of spinal inflammation on MRI in patients with chronic back pain (CBP) of maximally 3 years duration and to evaluate the yield of adding a positive MRI-spine as imaging criterion to the Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axial spondyloarthritis (axSpA). METHODS: Baseline imaging of the sacroiliac joints (X-SI), MRI of the sacroiliac joints (MRI-SI) and MRI-spine were scored by ≥2 experienced central readers per modality in the SPondyloArthritis Caught Early (SPACE) and DEvenir des Spondylarthropathies Indifférenciées Récentes (DESIR) cohorts...
October 2017: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/28473425/a-nationwide-non-medical-switch-from-originator-infliximab-to-biosimilar-ct-p13-in-802-patients-with-inflammatory-arthritis-1-year-clinical-outcomes-from-the-danbio-registry
#18
JOURNAL ARTICLE
Bente Glintborg, Inge Juul Sørensen, Anne Gitte Loft, Hanne Lindegaard, Asta Linauskas, Oliver Hendricks, Inger Marie Jensen Hansen, Dorte Vendelbo Jensen, Natalia Manilo, Jakob Espesen, Mette Klarlund, Jolanta Grydehøj, Sabine Sparre Dieperink, Salome Kristensen, Jimmi Sloth Olsen, Henrik Nordin, Stavros Chrysidis, Dorte Dalsgaard Pedersen, Michael Veedfald Sørensen, Lis Smedegaard Andersen, Kathrine Lederballe Grøn, Niels Steen Krogh, Lars Pedersen, Merete Lund Hetland
OBJECTIVES: According to guidelines, a nationwide non-medical switch from originator (INX, Remicade) to biosimilar infliximab (Remsima, CT-P13) was conducted in Danish patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (AxSpA). We investigated disease activity before/after switching and retention rates in the DANBIO registry. METHODS: Disease activities 3 months before and after switch and changes over time were calculated...
August 2017: Annals of the Rheumatic Diseases
https://read.qxmd.com/read/28351491/vegf-inhibition-as-possible-therapy-in-spondyloarthritis-patients-targeting-bone-remodelling
#19
JOURNAL ARTICLE
Alexis Lacout, Robert Yves Carlier, Mostafa El Hajjam, Pierre Yves Marcy
Spondyloarthritis refers to a group of chronic inflammatory rheumatic diseases that predominantly affects the axial skeleton, causing pain and stiffness. Human bone is highly dynamic organ that interacts with a wide array cells and tissues. Process of bone remodelling relies on a delicate balance between bone formation and bone resorption, orchestrated by osteoblasts and osteoclasts. Disruption of this homeostatic balance of bone removal and replacement can manifest as inappropriate new bone formation found in spondylarthritis...
April 2017: Medical Hypotheses
https://read.qxmd.com/read/28283515/comparison-of-mri-with-radiography-for-detecting-structural-lesions-of-the-sacroiliac-joint-using-ct-as-standard-of-reference-results-from-the-simact-study
#20
COMPARATIVE STUDY
Torsten Diekhoff, Kay-Geert A Hermann, Juliane Greese, Carsten Schwenke, Denis Poddubnyy, Bernd Hamm, Joachim Sieper
OBJECTIVE: Radiographs of sacroiliac (SI) joints are used for the detection of structural damage in patients with axial spondyloarthritis (axSpA), but are often difficult to interpret. Here, we address the question how the T1-weighted MRI (T1w MRI) sequence compares with radiography for SI joints' structural lesions using low-dose CT as the standard of reference. METHODS: Radiographs, T1w MRI and low-dose CT of the SI joints from 110 patients (mean age 36.1 (19-57) years, 52% males and 48% females; 53% with axSpA, 21 non-radiographic axSpA and 32% radiographic axSpA, 47% with non-SpA) referred to the rheumatologist because of unclear chronic back pain, but possible axSpA, were scored for structural lesions (erosions, sclerosis, joint space changes and an overall impression of positivity)...
September 2017: Annals of the Rheumatic Diseases
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