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Mesoporous silica

Maneea Eizadi Sharifabad, Tim Mercer, Tapas Sen
Liposome-capped core-shell mesoporous silica-coated superparamagnetic iron oxide nanoparticles called 'magnetic protocells' were prepared as novel nanocomposites and used for loading anticancer drug doxorubicin (DOX) for cellular toxicity study. Cytotoxicity of the magnetic protocells with or without DOX was tested in vitro on commercial MCF7 and U87 cell lines under alternating magnetic field. MCF7 cell line treated with the DOX-loaded nanoparticles under alternating magnetic field exhibited nearly 20% lower survival rate after 24 h compared with cells treated with free DOX and similarly, it was around 24% when applied to U87...
October 19, 2016: Nanomedicine
Qing Zhang, Haoyu Zhao, Dong Li, Liping Liu, Shuhu Du
To achieve drug targeting and on-demand releasing, surface functionalization plays a critical role in fabricating potential mesoporous silica nanoparticles (MSNs) toward tumor chemotherapy. Here, we prepared a size-controllable ligand-functionalized MSNs delivery system via coordinate bonding, which can release doxorubicin (DOX) in response to pH and prolong the circulation time of drug in vivo. After modifying the external surface of MSNs with polyethylene glycol (PEG), iminodiacetic acid (IDA) as a ligand was mainly grafted on the surface of mesopores to chelate cupric iron and DOX in sequence via coordinate bonds...
October 11, 2016: Colloids and Surfaces. B, Biointerfaces
Shenli Zhang, Maria Perez-Page, Kelly Guan, Erick Yu, Joseph W Tringe, Ricardo H R Castro, Roland Faller, Pieter Stroeve
Molecular Dynamics (MD) and Monte Carlo (MC) simulations were applied together for the first time to reveal the porous structure transformation mechanisms of mesoporous silica MCM-41 subjected to temperatures up to 2885 K. Silica was experimentally characterized to inform the models and enable prediction of changes in gas adsorption/separation properties. MD simulations suggest that the pore closure process is activated by a collective diffusion of matrix atoms into the porous region, accompanied by bond reformation at the surface...
October 17, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
Leandro P Ravaro, Tiago R Almeida, Rodrigo Q Albuquerque, Andrea S S de Camargo
The polynuclear complex Cu4I4py4 has been largely studied in solution and in the powder form due to its interesting luminescent properties, which are largely dependent on temperature and pressure. In this work, we present the synthesis of the complex and its wet impregnation in a mesoporous silica host obtained by sol-gel methodology. For optimized loadings, the well-dispersed guest molecules exhibit strong interaction with molecular oxygen, resulting in a significant quenching of the luminescence. The process is highly reversible with a Stern-Volmer constant of Ksv = 33...
October 17, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Mingzhen Zhang, Changlong Xu, Liuqing Wen, Moon Kwon Han, Bo Xiao, Jun Zhou, Yuchen Zhang, Zhan Zhang, Emilie Viennois, Didier Merlin
The ability of nanoparticles to target tumors and to enable site-specific drug release provides a unique system for the delivery of effective therapy with reduced toxic side effects. In this study, we used mesoporous silica nanoparticles (MSN) to fabricate a targeted drug delivery system that is responsive to hyaluronidase (HAase). Following engraftment of desthiobiotin onto the surface of MSN, a streptavidin complex was generated which was functionalized with biotin-modified hyaluronic acid (HA) to enable controlled drug release at cancer cells expressing HAase...
October 14, 2016: Cancer Research
Gerhard Fritz-Popovski, Roland Morak, Parvin Sharifi, Heinz Amenitsch, Oskar Paris
Mesoporous silica films templated by pluronic P123 were prepared using spin and dip coating. The ordered cylindrical structure within the films deforms due to shrinkage during calcination. Grazing-incidence small-angle X-ray scattering (GISAXS) measurements reveal that both the unit cell and the cross section of the pores decrease in size, mainly normal to the surface of the substrate, leading to elliptical cross sections of the pores with axis ratios of about 1:2. Water take-up by the pores upon changing the relative humidity can be monitored quantitatively by the shift in the critical angle of X-ray reflection as seen by the Yoneda peak...
October 1, 2016: Journal of Applied Crystallography
Xianxian Yao, Xingxing Niu, Kexin Ma, Ping Huang, Julia Grothe, Stefan Kaskel, Yufang Zhu
A multifunctional platform is reported for synergistic therapy with controlled drug release, magnetic hyperthermia, and photothermal therapy, which is composed of graphene quantum dots (GQDs) as caps and local photothermal generators and magnetic mesoporous silica nanoparticles (MMSN) as drug carriers and magnetic thermoseeds. The structure, drug release behavior, magnetic hyperthermia capacity, photothermal effect, and synergistic therapeutic efficiency of the MMSN/GQDs nanoparticles are investigated. The results show that monodisperse MMSN/GQDs nanoparticles with the particle size of 100 nm can load doxorubicin (DOX) and trigger DOX release by low pH environment...
October 13, 2016: Small
Jie Cao, Charl J Jafta, Jiang Gong, Qidi Ran, Xianzhong Lin, Roberto Félix, Regan G Wilks, Marcus Bär, Jiayin Yuan, Matthias Ballauff, Yan Lu
In this study, dispersible mesoporous nitrogen-doped hollow carbon nanoplates have been synthesized as a new anisotropic carbon nanostructure using gibbsite nanoplates as templates. The gibbsite-silica core-shell nanoplates were first prepared before the gibbsite core was etched away. Dopamine as carbon precursor was self-polymerized on the hollow silica nanoplates surface assisted by sonification, which not only favors a homogeneous polymer coating on the nanoplates but also prevents their aggregation during the polymerization...
October 13, 2016: ACS Applied Materials & Interfaces
Chaoting Zeng, Wenting Shang, Xiaoyuan Liang, Xiao Liang, Qingshan Chen, Chongwei Chi, Yang Du, Chihua Fang, Jie Tian
To improve patient outcome and decrease overall health-care costs, highly sensitive and precise detection of a tumor is required for its accurate diagnosis and efficient therapy; however, this remains a challenge when using conventional single mode imaging. Here, we successfully designed a near-infrared ray (NIR)-response photothermal therapy (PTT) platform (Au@MSNs-ICG) for the location, diagnosis, and NIR/computer tomography (CT) bimodal imaging-guided PTT of tumor tissues, using gold (Au) nanospheres coated with indocyanine green (ICG)-loaded mesoporous silica nanoparticles (MSNs), which would have high sensitivity and precision...
October 12, 2016: ACS Applied Materials & Interfaces
Xiaojun Liu, Shouzhong Zou, Shaowei Chen
Doping with foreign atoms is an effective approach to significantly enhance the catalytic performance of carbon materials for oxygen reduction reaction (ORR). In this paper, a colloidal silica template method was employed to synthesize nitrogen and iron codoped ordered mesoporous carbon for ORR electrocatalysis. The carbon materials were thoroughly characterized by transmission electron microscopy, Raman spectroscopy, X-ray diffraction, and X-ray photoelectron spectroscopy measurements. The porosity was quantified by nitrogen adsorption/desorption measurements that showed the formation of ordered mesoporous structures with a BET specific surface area up to 953...
October 11, 2016: Nanoscale
Chandran Murugan, Kathirvel Rayappan, Ramar Thangam, Ramasamy Bhanumathi, Krishnamurthy Shanthi, Raju Vivek, Ramasamy Thirumurugan, Atanu Bhattacharyya, Srinivasan Sivasubramanian, Palani Gunasekaran, Soundarapandian Kannan
Combination therapy of multiple drugs through a single system is exhibiting high therapeutic effects. We investigate nanocarrier mediated inhibitory effects of topotecan (TPT) and quercetin (QT) on triple negative breast cancer (TNBC) (MDA-MB-231) and multi drug resistant (MDR) type breast cancer cells (MCF-7) with respect to cellular uptake efficiency and therapeutic mechanisms as in vitro and in vivo. The synthesized mesoporous silica nanoparticle (MSN) pores used for loading TPT; the outer of the nanoparticles was decorated with poly (acrylic acid) (PAA)-Chitosan (CS) as anionic inner-cationic outer layer respectively and conjugated with QT...
October 11, 2016: Scientific Reports
Dr Merel van Elk, Dr Bruce P Murphy, Tatiane Eufrásio-da-Silva, Daniel P O'Reilly, Dr Tina Vermonden, Prof Wim E Hennink, Dr Garry P Duffy, Dr Eduardo Ruiz-Hernández
The development of nanomedicines for the treatment of cancer focuses on the local targeted delivery of chemotherapeutic drugs to enhance drug efficacy and reduce adverse effects. The nanomedicines which are currently approved for clinical use are mainly successful in terms of improved bioavailability and tolerability but do not necessarily increase drug performance. Therefore, there is a need for improved drug carrier systems which are able to deliver high doses of anti-cancer drugs to the tumor. Stimuli responsive carriers are promising candidates since drug release can be triggered locally in the tumor via internal (i...
October 7, 2016: International Journal of Pharmaceutics
Dong Zhu, Jing Ye, Yue Hu, Hong Mei Wen, An Kang, Yu-Ping Tang, Jun Chen, Chen Xiao Shan, Xiao Bing Cui
A combined specific enrichment and highly efficient solid-phase tagging approach is presented for heparin detection using boronic acid-functionalized mesoporous silica nanospheres as extraction sorbents and nanoscale reactors. It exhibits a faster reaction time (only 6 min), higher tagging-product purity and lower applicable sample concentration compared with liquid-phase tagging.
September 27, 2016: Chemical Communications: Chem Comm
Li Qiao, Xia Wang, Yawei Gao, Qingcong Wei, Wen Hu, Lei Wu, Pei Li, Rongrong Zhu, Qigang Wang
In this work, we designed a new hybrid nanogel with redox responsive polymer gel shells and mesoporous silica nanoparticles (MSNs) cores via laccase-mediated radical polymerization. The successful coating of the responsive gel shells on the MSNs was confirmed by the morphology and increased diameters of the particles as determined by transmission electron microscopy (TEM) and dynamic light scattering (DLS). As observed by scanning transmission electron microscopy (STEM) and energy dispersive X-ray spectroscopy (EDS), the presence of the element S around the MSNs further confirmed the formation of the gel shell...
October 6, 2016: Nanoscale
Nadya Velikova, Nuria Mas, Laura Miguel-Romero, Lorena Polo Aguado, Ellen Stolte, Edoardo Zaccaria, Rui Cao, Nico Taverne, José Ramón Murguía, Ramon Martinez-Manez, Alberto Marina, Jerry Wells
Two-component systems (TCS) regulate diverse processes such as virulence, stress responses, metabolism and antibiotic resistance in bacteria but are absent in humans, making them promising targets for novel antibacterials. By incorporating recently described TCS histidine kinase autophosphorylation inhibitors (HKAIs) into ε-poly-L-lysine capped nanoparticles (NPs) we could overcome the Gram negative (Gr-) permeability barrier for the HKAIs. The observed bactericidal activity against Gr- bacteria was shown to be due to the enhanced delivery and internalization of the HKAIs and not an inhibitory or synergistic effect of the NPs...
October 5, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
María Ruiz-Rico, Édgar Pérez-Esteve, María J Lerma-García, María D Marcos, Ramón Martínez-Máñez, José M Barat
Folic acid (FA) is a synthetic vitamin commonly used for food fortification. However, its vulnerability to processing and storage implies loss of efficiency, which would induce over-fortification by processors to obtain a minimum dose upon consumption. Recent studies have indicated potential adverse effects of FA overdoses, and FA protection during processing and storage could lead to more accurate fortification. In addition, sustained vitamin release after consumption would help improve its metabolism. The objective of this work was to study controlled FA delivery and stability in fruit juices to reduce potential over-fortification risks by using gated mesoporous silica particles (MSPs)...
March 1, 2017: Food Chemistry
Huayao Chen, Yueshun Lin, Hongjun Zhou, Xinhua Zhou, Sheng Gong, Hua Xu
The salicylaldehyde modified mesoporous silica (SA-MCM-41) was prepared through a co-condensation method. Through the bridge effect from copper ion which also acts as the nutrition of the plant, the model drug- chlorpyrifos(CH) was supported on the copper(II)/Schiff base mesoporous silica (Cu-MCM-41) to form a highly efficient sustained released system (CH-Cu-MCM-41) for pesticide delivery. The experimental results showed that the larger the concentration of copper ion was, the more adsorption capacity (AC) of Cu-MCM-41 for chlorpyrifos was and the smaller its release rate was...
October 7, 2016: Journal of Agricultural and Food Chemistry
Lin Xiong, Shi-Zhang Qiao
Mesoporous organosilica nanoparticles with a novel bowl-like morphology were synthesized. These nano-bowls possess uniform particle sizes around 180 nm and open cavities around 140 nm, which lead to higher loading capability for plasmid DNA than traditional silica-based nanoparticles. In vitro DNA transfection using these nano-bowls is demonstrated.
October 14, 2016: Nanoscale
Dong Xiao, Jing-Jing Hu, Jing-Yi Zhu, Shi-Bo Wang, Ren-Xi Zhuo, Xian-Zheng Zhang
In this study, we report a novel redox-responsive mesoporous silica nanoparticle (MSN)-based nanocarrier, capping with a therapeutic peptide ((RGDWWW)2KC) containing a RGD target motif, for tumor targeting synergistic therapy, which is designated as TTSTMSN. The MSN was decorated with a tumor-targeting therapeutic peptide as a potential gatekeeper. The two branched peptides containing rich tryptophans allowed the pores to be blocked via π-π stacking and hydrophobic interactions. Once the drug loaded nanoparticles were taken up by the cancer cells through integrin-mediated endocytosis, the therapeutic peptide capping shells on the surface of MSNs were released, inducing the loaded drug to diffuse into the cytoplasm after breaking of the disulfide bonds, triggered by the high concentration of glutathione (GSH) in cancer cells...
September 22, 2016: Nanoscale
Junho Hwang, Sho Kataoka, Akira Endo, Hirofumi Daiguji
Nanofluidic energy harvesting systems have attracted interest in the field of battery application, particularly for miniaturized electrical devices, because they possess excellent energy conversion capability for their size. In this study, a mesoporous silica (MPS)-based nanofluidic energy harvesting system was fabricated and selective ion transport in mesopores as a function of the salt gradient was investigated. Aqueous solutions with three different kinds of monovalent electrolytes-KCl, NaCl, and LiCl-with different diffusion coefficients (D+) were considered...
September 21, 2016: Lab on a Chip
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