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Mesoporous silica

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https://www.readbyqxmd.com/read/27913308/biodegradable-magnetic-silica-iron-oxide-nanovectors-with-ultra-large-mesopores-for-high-protein-loading-magnetothermal-release-and-delivery
#1
Haneen Omar, Jonas G Croissant, Kholod Alamoudi, Shahad Alsaiari, Ibrahim Alradwan, Majed A Majrashi, Dalaver H Anjum, Patricia Martins, Basem Moosa, Abdulaziz Almalik, Niveen M Khashab
The delivery of large cargos of diameter above 15nm for biomedical applications has proved challenging since it requires biocompatible, stably-loaded, and biodegradable nanomaterials. In this study, we describe the design of biodegradable silica-iron oxide hybrid nanovectors with large mesopores for large protein delivery in cancer cells. The mesopores of the nanomaterials spanned from 20 to 60nm in diameter and post-functionalization allowed the electrostatic immobilization of large proteins (e.g. mTFP-Ferritin, ~534kDa)...
November 29, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27910990/a-ph-responsive-sequential-disassembly-nanohybrid-for-mitochondrial-targeting
#2
Lijia Li, Wei Sun, Lian Li, Yuanyuan Liu, Lei Wu, Fengling Wang, Zhou Zhou, Zhirong Zhang, Yuan Huang
Cationic materials have been reported as promising tools for targeting to mitochondria which are the "power houses" and "metabolic garbage keepers" of cells. However, their positive nature also restricts their in vivo application due to the quick clearance. Herein, we fabricated a nanohybrid consisting of the pH-responsive N-(2-hydroxypropyl)methacrylamide (HPMA) co-polymer (R-P) shells and positive mesoporous silica nanoparticle cores via electrostatic interaction. The anticancer drug, docetaxel (DTX), was encapsulated in the positive MSN cores (MSN-DTX)...
December 2, 2016: Nanoscale
https://www.readbyqxmd.com/read/27905587/the-premolten-layer-of-ice-next-to-a-hydrophilic-solid-surface-correlating-adhesion-with-molecular-properties
#3
Jonathan F D Liljeblad, István Furó, Eric C Tyrode
In order to establish the potential correlation between the macroscopic ice adhesion and the molecular properties of the premolten layer (PML), the adhesion strength between ice and hydrophilic silica has been measured as a function of temperature. In addition, temperature-dependent molecular properties have been determined using techniques that are sensitive to different aspects of the PML, specifically total internal reflection (TIR) Raman, vibrational sum frequency (VSFS) and NMR spectroscopies. The ice shear adhesion strength was observed to increase linearly with decreasing temperature until -25 °C, where a plateau marked the adhesive strength having reached the cohesive strength of ice...
December 1, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27898016/recent-advances-on-inorganic-nanoparticle-based-cancer-therapeutic-agents
#4
REVIEW
Fenglin Wang, Chengyao Li, Jing Cheng, Zhiqin Yuan
Inorganic nanoparticles have been widely investigated as therapeutic agents for cancer treatments in biomedical fields due to their unique physical/chemical properties, versatile synthetic strategies, easy surface functionalization and excellent biocompatibility. This review focuses on the discussion of several types of inorganic nanoparticle-based cancer therapeutic agents, including gold nanoparticles, magnetic nanoparticles, upconversion nanoparticles and mesoporous silica nanoparticles. Several cancer therapy techniques are briefly introduced at the beginning...
November 25, 2016: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/27895544/mesoporous-silica-chip-enabled-peptide-profiling-as-an-effective-platform-for-controlling-bio-sample-quality-and-optimizing-handling-procedure
#5
Kai Liang, Hongmei Wu, Tony Y Hu, Yan Li
BACKGROUND: High quality clinical samples are critical for meaningful interpretation of data obtained in both basic and translational medicine. More specifically, optimized pre-analysis handling to bio-sample is crucial for avoiding biased analysis in a clinical setting. A universally applicable method for the evaluation of sample quality and pre-analysis handling is therefore in great demand. METHODS: The fingerprint pattern of low molecular weight (LMW) peptides in sera is directly associated with sample quality and handling process...
2016: Clinical Proteomics
https://www.readbyqxmd.com/read/27892555/one-pot-synthesis-of-micron-partly-hollow-anisotropic-dumbbell-shaped-silica-core-shell-particles
#6
Johannes Maisch, Farhad Jafarli, Thomas Chassé, Felix Blendinger, Alexander Konrad, Michael Metzger, Alfred J Meixner, Marc Brecht, L Dähne, Hermann A Mayer
A facile method is described to prepare micron partly hollow dumbbell silica particles in a single step. The obtained particles consist of a large dense part and a small hollow lobe. The spherical dense core as well as the hollow lobe are covered by mesoporous channels. In the case of the smaller lobe these channels are responsible for the permeability of the shell which was demonstrated by confocal imaging and spectroscopy.
November 28, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27890656/nanoparticle-delivery-of-sirna-against-twist-to-reduce-drug-resistance-and-tumor-growth-in-ovarian-cancer-models
#7
Cai M Roberts, Sophia Allaf Shahin, Wei Wen, James B Finlay, Juyao Dong, Ruining Wang, Thanh H Dellinger, Jeffrey I Zink, Fuyuhiko Tamanoi, Carlotta A Glackin
Epithelial ovarian cancer (EOC) is the most deadly gynecologic malignancy on account of its late stage at diagnosis and frequency of drug resistant recurrences. Novel therapies to overcome these barriers are urgently needed. TWIST is a developmental transcription factor reactivated in cancers and linked to angiogenesis, metastasis, cancer stem cell phenotype, and drug resistance, making it a promising therapeutic target. In this work, we demonstrate the efficacy of TWIST siRNA (siTWIST) and two nanoparticle delivery platforms to reverse chemoresistance in EOC models...
November 25, 2016: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/27886289/hydration-in-silica-based-mesoporous-materials-a-dft-model
#8
Maciej Gierada, Ivan Petit, Jarosław Handzlik, Frederik Tielens
The MCM-41 material is very commonly used as a support for catalysts. However, theoretical investigations are significantly limited due to the lack of appropriate models that well and accurately describe the real material and enable effective computation at the same time. In this work, our aim is to obtain calculable models at the DFT level of MCM-41 which are as close as possible to the real material. In particular the hydration degree has been investigated, and we present and characterize here for the first time a model for the MCM-41 unit cell filled with explicit solvent water molecules...
November 25, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27877873/preparation-of-magnetic-mesoporous-silica-nanoparticles-as-a-multifunctional-platform-for-potential-drug-delivery-and-hyperthermia
#9
Xia Yu, Yufang Zhu
We report the preparation of magnetic mesoporous silica (MMS) nanoparticles with the potential multifunctionality of drug delivery and magnetic hyperthermia. Carbon-encapsulated magnetic colloidal nanoparticles (MCN@C) were used to coat mesoporous silica shells for the formation of the core-shell structured MMS nanoparticles (MCN@C/mSiO2), and the rattle-type structured MMS nanoparticles (MCN/mSiO2) were obtained after the removal of the carbon layers from MCN@C/mSiO2 nanoparticles. The morphology, structure, magnetic hyperthermia ability, drug release behavior, in vitro cytotoxicity and cellular uptake of MMS nanoparticles were investigated...
2016: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/27875331/amine-functionalized-cubic-mesoporous-silica-nanoparticles-as-an-oral-delivery-system-for-curcumin-bioavailability-enhancement
#10
Sandy Budi Hartono, Lannie Hadisoewignyo, Yanan Yang, Anand Kumar Meka, Antaresti, Chengzhong Yu
In the present work, a simple method was used to develop composite curcumin-amine functionalized mesoporous silica nanoparticles (MSN). The nanoparticles were used to improve the bioavailability of curcumin in mice through oral administration. We investigated the effect of particle size on the release profile, solubility and oral bioavailability of curcumin in mice, including amine functionalized mesoporous silica micron-sized-particles (MSM) and MSN (100-200 nm). Curcumin loaded within amine functionalized MSN (MSN-A-Cur) had a better release profile and a higher solubility compared to amine MSM (MSM-A-Cur)...
December 16, 2016: Nanotechnology
https://www.readbyqxmd.com/read/27874119/-99m-tc-conjugated-manganese-based-mesoporous-silica-nanoparticles-for-spect-ph-responsive-mri-and-anti-cancer-drug-delivery
#11
Hongbo Gao, Xiaohang Liu, Wei Tang, Dechao Niu, Bingni Zhou, Hua Zhang, Wei Liu, Bingxin Gu, Xiaobao Zhou, Yingying Zheng, Yiyun Sun, Xiaobo Jia, Liangping Zhou
In recent decades, hybrid imaging techniques that exploit the advantages of multiple imaging technologies have aroused extensive attention due to the deficiencies of single imaging modes. Along with the development of single photon emission computed tomography-magnetic resonance imaging (SPECT-MRI), it is currently necessary to develop a series of dual probes that can combine the outstanding sensitivity of SPECT with the high spatial resolution of MRI. Herein, the commonly used technetium-99 ((99m)Tc) was labelled on the surface of manganese oxide-based mesoporous silica nanoparticles (MnOx-MSNs) for use in SPECT-MRI dual-modal imaging...
December 1, 2016: Nanoscale
https://www.readbyqxmd.com/read/27871833/oral-hesperidin-amorphization-and-improved-dissolution-properties-by-controlled-loading-onto-porous-silica
#12
Qionghua Wei, Cornelia M Keck, Rainer H Müller
The oral bioavailability of poorly soluble drugs can be improved by amorphization generated by loading into the pores of mesoporous particles (pore size 2-50nm). The main mechanisms are increased kinetic saturation solubility and dissolution velocity due to the amorphous drug state and the nano-size of the drug (=increased dissolution pressure). In this study, the maximum achievable drug loading compared to the theoretical drug loading, and the effect of drug loading degree on the dissolution properties (solubility, dissolution velocity) were investigated...
November 18, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/27871003/magnetic-mesoporous-nanospheres-anchored-with-lyp-1-as-an-efficient-pancreatic-cancer-probe
#13
Yongjian Jiang, Shaojun Liu, Yu Zhang, Hengchao Li, Hang He, Juntao Dai, Tao Jiang, Weihang Ji, Daoying Geng, Ahmed A Elzatahry, Abdulaziz Alghamdi, Deliang Fu, Yonghui Deng, Dongyuan Zhao
Immobilization of a ligand that selectively interacts with cancer cells to nanomaterials can enhance their diagnostic and therapeutic efficiency. In this study, we firstly demonstrate the high expression of receptor for cyclic nine-amino acid peptide LyP-1 (Cys-Gly-Asn-Lys-Arg-Thr-Arg-Gly-Cys) in both mouse and human pancreatic cancer. Based on these findings, sub-50 nm multifunctional superparamagnetic mesoporous nanospheres with surface modified with LyP-1 are rationally designed. Theses nanospheres have a core of silica-protected magnetite nanoparticle and a shell of FITC-labeled mesoporous silica, and they are able to specifically recognize and conjugate with the pancreatic cancer cell in vitro, as verified by the combined techniques of fluorescent imaging and T2 weight magnetic resonance imaging...
November 11, 2016: Biomaterials
https://www.readbyqxmd.com/read/27869912/correction-in-solution-sers-sensing-using-mesoporous-silica-coated-gold-nanorods
#14
Zhe Gao, Nathan D Burrows, Nicholas A Valley, Sam Egger, George C Schatz, Catherine J Murphy, Christy L Haynes
Correction for 'In solution SERS sensing using mesoporous silica-coated gold nanorods' by Zhe Gao, et al., Analyst, 2016, 141, 5088-5095.
November 21, 2016: Analyst
https://www.readbyqxmd.com/read/27869768/synthesis-of-non-toxic-silica-particles-stabilized-by-molecular-complex-oleic-acid-sodium-oleate
#15
Catalin Ilie Spataru, Raluca Ianchis, Cristian Petcu, Cristina Lavinia Nistor, Violeta Purcar, Bogdan Trica, Sabina Georgiana Nitu, Raluca Somoghi, Elvira Alexandrescu, Florin Oancea, Dan Donescu
The present work is focused on the preparation of biocompatible silica particles from sodium silicate, stabilized by a vesicular system containing oleic acid (OLA) and its alkaline salt (OLANa). Silica nanoparticles were generated by the partial neutralization of oleic acid (OLA), with the sodium cation present in the aqueous solutions of sodium silicate. At the molar ratio OLA/Na⁺ = 2:1, the molar ratio (OLA/OLANa = 1:1) required to form vesicles, in which the carboxyl and carboxylate groups have equal concentrations, was achieved...
November 19, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27862953/dual-stimuli-responsive-nanotheranostics-for-multimodal-imaging-guided-trimodal-synergistic-therapy
#16
Shan Fang, Jing Lin, Chunxiao Li, Peng Huang, Wenxiu Hou, Chunlei Zhang, Jingjing Liu, Sisi Huang, Yongxiang Luo, Wenpei Fan, Daxiang Cui, Yunsheng Xu, Zhiming Li
Multimodal imaging guided synergistic therapy promises more accurate diagnosis than any single imaging modality, and higher therapeutic efficiency than any single one or their simple "mechanical" combination. Herein, we report a dual-stimuli responsive nanotheranostic based on a hierarchical nanoplatform, composed of mesoporous silica-coated gold nanorods (GNR@SiO2), Indocyanine Green (ICG), and 5-fluorouracil (5-FU), for in vivo multimodal imaging guided synergistic therapy. The 5-FU loaded ICG-conjugated silica-coated gold nanorods (GNR@SiO2-5-FU-ICG) was able to response specifically to the two stimuli of pH change and near-infrared (NIR) light irradiation...
November 15, 2016: Small
https://www.readbyqxmd.com/read/27860353/hollow-carbon-nanospheres-with-tunable-hierarchical-pores-for-drug-gene-and-photothermal-synergistic-treatment
#17
Xin Du, Caixia Zhao, Mengyun Zhou, Tianyi Ma, Hongwei Huang, Mietek Jaroniec, Xueji Zhang, Shi-Zhang Qiao
Design and synthesis of porous and hollow carbon spheres have attracted considerable interest in the past decade due to their superior physicochemical properties and widespread applications. However, it is still a big challenge to achieve controllable synthesis of hollow carbon nanospheres with center-radial large mesopores in the shells and inner surface roughness. Herein, porous hollow carbon nanospheres (PHCNs) are successfully synthesized with tunable center-radial mesopore channels in the shells and crater-like inner surfaces by employing dendrimer-like mesoporous silica nanospheres (DMSNs) as hard templates...
November 15, 2016: Small
https://www.readbyqxmd.com/read/27859880/self-regulated-glucose-sensitive-neoglycoenzyme-capped-mesoporous-silica-nanoparticles-for-insulin-delivery
#18
Mar Oroval, Paula Díez, Elena Aznar, Carmen Coll, María Dolores Marcos, Félix Sancenón, Reynaldo Villalonga, Ramón Martínez-Máñez
We describe herein the preparation of glucose-sensitive capped mesoporous silica nanoparticles for insulin delivery. The new material consists of an expanded pore nanometric silica support grafted with 1-H-propyl-1-H-benzimidazole groups, loaded with fluorescein isothiocyanate-labeled insulin (FITC-Ins) and capped by the formation of inclusion complexes between CD-modified-glucose oxidase (CD-GOx) and the benzimidazole groups grafted on the mesoporous support. Insulin delivery from the gated material in simulated blood plasma was assessed upon addition of glucose...
November 9, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27859828/synthesis-of-polydopamine-like-nanocapsules-via-removal-of-a-sacrificial-mesoporous-silica-template-with-water
#19
Daniel Ruiz-Molina, Fabiana Nador, Eduardo Guisasola, Alejandro Baeza, Maria Vallet Regi
Hollow polymeric PDA micro-/nanocapsules have been obtained through a very simple, mild and straightforward method that involves coating of silica mesoporous nanoparticles through an ammonia-triggered polymerization of PDA and the posterior removal of the sacrificial template simply by dispersion in water, without the need of any harsh chemical reagent, either in the presence or absence of active principles, from doxorubicin to iron oxide nanoparticles. To demonstrate the potential of the nanocapsules obtained with this new approach, they have been successfully used as nanocarriers for drug delivery...
November 18, 2016: Chemistry: a European Journal
https://www.readbyqxmd.com/read/27858044/the-timeline-of-corona-formation-around-silica-nanocarriers-highlights-the-role-of-the-protein-interactome
#20
Cédric Pisani, Jean-Charles Gaillard, Michaël Odorico, Jeff L Nyalosaso, Clarence Charnay, Yannick Guari, Joël Chopineau, Jean-Marie Devoisselle, Jean Armengaud, Odette Prat
Magnetic mesoporous silica nanoparticles (M-MSNs) represent promising targeting tools for theranostics. Engineering the interaction of nanoparticles (NPs) with biological systems requires an understanding of protein corona formation around the nanoparticles as this drives the biological fate of nanocarriers. We investigated the behavior of proteins in contact with M-MSNs by high-throughput comparative proteomics, using human and bovine sera as biological fluids, in order to assess the adsorption dynamics of proteins in these media...
November 18, 2016: Nanoscale
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