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Mesoporous silica

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https://www.readbyqxmd.com/read/28229590/impacts-of-crosslinkers-on-biological-effects-of-mesoporous-silica-nanoparticles
#1
Yi-Ping Chen, Si-Han Wu, I-Chih Chen, Chien-Tsu Chen
Chemically synthesized crosslinkers play decisive roles in variable cargos attached to nanoparticles (NPs). Previous studies reported that surface properties, such as the size, charge, and surface chemistry, are particularly important determinants influencing the biological fate and actions of NPs and cells. Recent studies also focused on the relationship of serum proteins with the surface properties of NPs (also called the protein corona), which is recognized as a key factor in determining the cytotoxicity and biodistribution...
February 23, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28226244/molecularly-organic-inorganic-hybrid-hollow-mesoporous-organosilica-nanocapsules-with-tumor-specific-biodegradability-and-enhanced-chemotherapeutic-functionality
#2
Ping Huang, Yu Chen, Han Lin, Luodan Yu, Linlin Zhang, Liying Wang, Yufang Zhu, Jianlin Shi
Based on the intrinsic features of high stability and unique multifunctionality, inorganic nanoparticles have shown remarkable potentials in combating cancer, but their biodegradability and biocompatibility are still under debate. As a paradigm, this work successfully demonstrates that framework organic-inorganic hybridization can endow the inorganic mesoporous silica nanocarriers with unique tumor-sensitive biodegradability and high biocompatibility. Based on a "chemical homology" mechanism, molecularly organic-inorganic hybridized hollow mesoporous organosilica nanocapsules (HMONs) with high dispersity and sub-50 nm particle dimension were constructed in mass production...
February 15, 2017: Biomaterials
https://www.readbyqxmd.com/read/28221001/synthesis-of-dual-stimuli-responsive-microcontainers-with-two-payloads-in-different-storage-spaces-for-preprogrammable-release
#3
Ying Cong, Qiuju Li, Min Chen, Limin Wu
Stimuli-responsive microcontainers have become a major topic of interest, from fundamental aspects to applications in materials science. However, microcontainers that enable the loading of multiple species and programmable release are mostly unexplored. Herein, we describe the design and synthesis of a dual-responsive organic/inorganic hybrid microcontainer with two payloads in separate storage spaces that is formed by the rapid UV-initiated polymerization of Pickering emulsions. The stellate mesopore silica nanoparticles with poly(N-isopropylacrylamide) grafted inside the mesopores were loaded with one compound (Nile red) and used as Pickering emulsifiers to stabilize oil-in-water droplets...
February 21, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28220973/enzyme-controlled-nanodevice-for-acetylcholine-triggered-cargo-delivery-based-on-janus-au-mesoporous-silica-nanoparticles
#4
Antoni Llopis-Lorente, Paula Diez, Cristina de la Torre, Alfredo Sanchez, Felix Sancenon, Elena Aznar, Maria D Marcos, Paloma Martínez-Ruíz, Ramón Martínez-Máñez, Reynaldo Villalonga
This work reports a new gated nanodevice for acetylcholine-triggered cargo delivery. We prepared and characterized Janus Au-mesoporous silica nanoparticles functionalized with acetylcholinesterase on the Au face and with supramolecular β-cyclodextrin:benzimidazole inclusion complexes as caps on the mesoporous silica face. The nanodevice is able to selectively deliver the cargo in the presence of acetylcholine via enzyme-mediated acetylcholine hydrolysis, locally lowering the pH and opening the supramolecular gate...
February 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28220694/selective-fluorogenic-sensing-of-as-iii-using-aptamer-capped-nanomaterials
#5
Mar Oroval, Carmen Coll, Andrea Bernardos, María Dolores Marcos, Ramon Martinez-Manez, Dmitry G Shchukin, Felix Sancenón
Organic-inorganic hybrid nanomaterials offer extremely valuable tools for monitoring many types of analytes in in solution. Within this framework, aptamer-based nanomaterials for heavy metal detection are still very scarce. Herein, a novel sensing nanoprobe for the selective and sensitive detection of As(III) based on the combination of aptamers with mesoporous silica nanoparticles has been developed. The efficiency of the sensor is demonstrated in environmental conditions, showing a great potential in As(III) monitoring assays...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28218828/a-simple-and-facile-approach-to-create-charge-reversible-pores-via-hydrophobic-anchoring-of-ionic-amphiphiles
#6
Sonu Kizhakeppura, B V V S Pavan Kumar, Subi J George, Muthusamy Eswaramoorthy
Mesoporous silica based charge reversal systems have gained significant attention in the recent years due to a variety of applications such as drug delivery, dye adsorption, catalysis, chromatography etc. Such systems often use covalent strategies to immobilize functional groups on the silica scaffold. However, lack of dynamism, modularity and post-synthetic flexibility associated with covalent routes limit their wider applicability. Alternatively, supramolecular routes are gaining increased attention owing to their ability to overcome these limitations...
February 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28212981/development-of-solid-sedds-vi-effect-of-precoating-of-neusilin%C3%A2-us2-with-pvp-on-drug-release-from-adsorbed-self-emulsifying-lipid-based-formulations
#7
Suhas G Gumaste, Beatryz O S Freire, Abu T M Serajuddin
Adsorption of lipid-based formulations, which are usually liquid, onto silicas has been extensively investigated in the past decade to convert them into solid dosage forms. There are conflicting reports on the ability of commercially available porous silicas, like Neusilin® US2, to release lipid formulations completely, especially after long-term storage. In this study, the release of a model drug, probucol, from different formulations of medium chain lipids and a surfactant, Kolliphor EL (Cremophor EL) or polysorbate 80, were studied after adsorbing them onto Neusilin® US2...
February 14, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28212271/carbon-nanotubes-as-an-effective-opportunity-for-cancer-diagnosis-and-treatment
#8
REVIEW
Alessandro Sanginario, Beatrice Miccoli, Danilo Demarchi
Despite the current progresses of modern medicine, the resistance of malignant tumors to present medical treatments points to the necessity of developing new therapeutic approaches. In recent years, numerous studies have focused their attention on the promising use of nanomaterials, like iron oxide nanowires, zinc oxide or mesoporous silica nanoparticles, for cancer and metastasis treatment with the advantage of operating directly at the bio-molecular scale. Among them, carbon nanotubes emerged as valid candidates not only for drug delivery, but also as a valuable tool in cancer imaging and physical ablation...
February 15, 2017: Biosensors
https://www.readbyqxmd.com/read/28202192/ordered-mesoporous-silica-functionalized-with-%C3%AE-cyclodextrin-derivative-for-stereoisomer-separation-of-flavanones-and-flavanone-glycosides-by-nano-liquid-chromatography-and-capillary-electrochromatography
#9
Mariana Silva, Damián Pérez-Quintanilla, Sonia Morante-Zarcero, Isabel Sierra, María Luisa Marina, Zeineb Aturki, Salvatore Fanali
In this paper a chiral stationary phase (CSP) was prepared by the immobilization of a β-CD derivative (3,5-dimethylphenylcarbamoylated β-CD) onto the surface of amino-functionalized spherical ordered mesoporous silica (denoted as SM) via a urea linkage using the Staudinger reaction. The CSP was packed into fused silica capillaries 100μm I.D. and evaluated by means of nano-liquid chromatography (nano-LC) and capillary electrochromatography (CEC) using model compounds for the enantio- and the diastereomeric separation...
February 9, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28199081/correction-to-a-mesoporous-silica-biomaterial-for-dental-biomimetic-crystallization
#10
Yu-Chih Chiang, Hong-Ping Lin, Hao-Hueng Chang, Ya-Wen Cheng, Hsin-Yen Tang, Wei-Ching Yen, Po-Yen Lin, Kei-Wen Chang, Chun-Pin Lin
No abstract text is available yet for this article.
February 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/28195458/tuning-the-interfacial-activity-of-mesoporous-silicas-for-biphasic-interface-catalysis-reactions
#11
Fen Xue, Yabin Zhang, Fengwei Zhang, Xiaomin Ren, Hengquan Yang
Interface-active particle materials that are able to assemble at the oil/water interface so as to stabilize droplets, are gaining unprecedented interest due to the intriguing applications in catalysis and materials synthesis, etc. In contrast to these potential applications, this kind of materials are still limited and cannot meet some particular demands of practical utilizations such as rationally designed interfacial activity and high stability against concentrated salts. In this contribution, interface-active mesoporous silica nanospheres (MSS@CxZy) are synthesized through simultaneous incorporation of extremely hydrophilic zwitterionic moiety and hydrophobic octyl moiety in the shell...
February 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28195398/preparation-of-magnetic-mesoporous-silica-composite-for-the-solid-phase-microextraction-of-diazinon-and-malathion-before-their-determination-by-high-performance-liquid-chromatography
#12
Alireza Bazmandegan-Shamili, Ali Mohammad Haji Shabani, Shayessteh Dadfarnia, Masoud Rohani Moghadam, Mahboubeh Saeidi
A novel magnetic mesoporous silica material was synthesized and used as the sorbent for the magnetic solid-phase microextraction of diazinon and malathion before their quantification by high-performance liquid chromatography with UV detection. The sorbent was synthesized by a surfactant-templated one-pot sol-gel procedure using SiO2 -coated Fe3 O4 as the magnetic support, cetyltrimethylammonium bromide as the template and tetraethyl orthosilicate as the silicon source. The characteristics of the prepared sorbent were investigated using FTIR spectroscopy, scanning electron microscopy, and X-ray diffraction...
February 13, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28194717/metal-chelate-immobilization-of-lipase-onto-polyethylenimine-coated-mcm-41-for-apple-flavor-synthesis
#13
Armin Sadighi, Seyed Farshad Motevalizadeh, Morteza Hosseini, Ali Ramazani, Lena Gorgannezhad, Hamid Nadri, Behnaz Deiham, Mohammad Reza Ganjali, Abbas Shafiee, Mohammad Ali Faramarzi, Mehdi Khoobi
An enzyme immobilized on a mesoporous silica nanoparticle can serve as a multiple catalyst for the synthesis of industrially useful chemicals. In this work, MCM-41 nanoparticles were coated with polyethylenimine (MCM-41@PEI) and further modified by chelation of divalent metal ions (M = Co(2+), Cu(2+), or Pd(2+)) to produce metal-chelated silica nanoparticles (MCM-41@PEI-M). Thermomyces lanuginosa lipase (TLL) was immobilized onto MCM-41, MCM-41@PEI, and MCM-41@PEI-M by physical adsorption. Maximum immobilization yield and efficiency of 75 ± 3...
February 13, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28194450/assessment-of-the-adjuvant-activity-of-mesoporous-silica-nanoparticles-in-recombinant-mycoplasma-hyopneumoniae-antigen-vaccines
#14
Veridiana Gomes Virginio, Natalia Costantin Bandeira, Fernanda Munhoz Dos Anjos Leal, Marcelo Lancellotti, Arnaldo Zaha, Henrique Bunselmeyer Ferreira
The adjuvant potential of two mesoporous silica nanoparticles (MSNs), SBa-15 and SBa-16, was assessed in combination with a recombinant HSP70 surface polypeptide domain from Mycoplasma hyopneumoniae, the etiological agent of porcine enzootic pneumonia (PEP). The recombinant antigen (HSP70212-600), previously shown as immunogenic in formulation with classic adjuvants, was used to immunize BALB/c mice in combination with SBa-15 or SBa-16 MSNs, and the effects obtained with these formulations were compared to those obtained with alum, the adjuvant traditionally used in anti-PEP bacterins...
January 2017: Heliyon
https://www.readbyqxmd.com/read/28193559/dual-functional-mesoporous-silicon-nanoparticles-enhance-the-radiosensitivity-of-vpa-in-glioblastoma
#15
Hailong Zhang, Wei Zhang, Yong Zhou, Yuhua Jiang, Shupeng Li
Radiotherapy is a critical strategy and standard adjuvant approach to glioblastoma treatment. One of the major challenges facing radiotherapy is to minimize radiation damage to normal tissue without compromising therapeutic effects on cancer cells. Various agents and numerous approaches have been developed to improve the therapeutic index of radiotherapy. Among them, radiosensitizers have attracted much attention because they selectively increase susceptibility of cancer cells to radiation and thus enhance biological effectiveness of radiotherapy...
February 10, 2017: Translational Oncology
https://www.readbyqxmd.com/read/28190837/analysis-of-distribution-and-intraparticle-diffusion-of-a-fluorescent-dye-in-mesoporous-silica-gel-by-confocal-fluorescence-microspectroscopy
#16
Tatsumi Sato, Kiyoharu Nakatani
A micrometer-sized spherical silica gel microparticle (pore diameter, ∼7 nm) was injected into an aqueous rhodamine 6G solution using microcapillary manipulation-injection technique, and the dye distribution in the single microparticle was measured as the fluorescence depth profile by confocal fluorescence microspectroscopy. The fluorescence depth profile was simulated by the convolution and deconvolution methods to correct the contribution of the spatial resolution of the experimental system. The dye homogeneously or heterogeneously distributed in the microparticle at the adsorption equilibrium, dependent on the type of silica gel...
2017: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
https://www.readbyqxmd.com/read/28189113/monodisperse-mesoporous-silica-nanoparticles-of-distinct-topology
#17
Leilei Luo, Yucang Liang, Egil Sev Erichsen, Reiner Anwander
Monodisperse and uniform high-quality MCM(Mobil Composition of Matter)-48-type CMSNs (Cubic Mesoporous Silica Nanoparticles) are readily prepared by simply optimizing the molar ratio of ethanol and surfactant in the system TEOS-CTAB-NaOH-H2O-EtOH (TEOS=tetraethyl orthosilicate, CTAB=cetyltrimethylammonium bromide, EtOH=ethanol). In the absence of ethanol only hexagonal mesoporous silica with ellipsoidal and spherical morphology are obtained. The presence of ethanol drives a mesophase transformation from hexagonal to mixed hexagonal/cubic, further to purely cubic, and finally to a mixed cubic/lamellar...
January 31, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28185452/organic-nanowire-sio2-core-shell-microlasers-with-highly-polarized-and-narrow-emissions-for-biological-imaging
#18
Changfu Feng, Zhenzhen Xu, Xu Wang, Hongjuan Yang, Lemin Zheng, Hongbing Fu
Development of luminescence probes with polarized and narrow emissions simultaneously is helpful for removing multiply scattered light and enables multiplexing detection, but it remains challenging to use conventional organic dyes, fluorescence proteins, and quantum dots. Here, we demonstrated smart one-dimensional microlaser probes (MLPs) by coating a thin layer of silica shell on the surface of organic nanowires (ONWs) of 1,4-dimethoxy-2,5-di[4'-(methylthio)styryl]benzene (TDSB), namely, ONW@SiO2 core-shell structures...
February 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28183632/a-potential-bioactive-wound-dressing-based-on-carboxymethyl-cellulose-zno-impregnated-mcm-41-nanocomposite-hydrogel
#19
Rasul Rakhshaei, Hassan Namazi
Lack of antibacterial activity, deficient water vapor and oxygen permeability, and insufficient mechanical properties are disadvantages of existing wound dressings. Hydrogels could absorb wound exudates due to their strong swelling ratio and give a cooling sensation and a wet environment. To overcome these shortcomings, flexible nanocomposite hydrogel films was prepared through combination of zinc oxide impregnated mesoporous silica (ZnO-MCM-41) as a nano drug carrier with carboxymethyl cellulose (CMC) hydrogel...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28183610/preparation-of-efficient-quercetin-delivery-system-on-zn-modified-mesoporous-sba-15-silica-carrier
#20
Ivalina Trendafilova, Agnes Szegedi, Judith Mihály, Georgi Momekov, Nadejda Lihareva, Margarita Popova
Mesoporous silica material type SBA-15 was modified with different amounts of Zn (2 and 4wt.%) by incipient wetness impregnation method in ethanol. The parent, Zn-modified and quercetin loaded samples, were characterized by XRD, N2 physisorption, TEM, thermal gravimetric analysis, UV-vis and FT-IR spectroscopies and in vitro release of quercetin at pH5.5 which is typical of dermal formulations. By this loading method anhydrous quercetin was formed on the silica carrier It was found that the different hydrate forms of quercetin (dihydrate, monohydrate, anhydrite) significantly influence the physico-chemical properties of the delivery system...
April 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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