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Mesoporous silica

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https://www.readbyqxmd.com/read/28650029/nanoparticle-encapsulated-baicalein-markedly-modulates-pro-inflammatory-response-in-gingival-epithelial-cells
#1
Xuan Li, Wei Luo, Tsz Wing Ng, Ping Chung Leung, Chengfei Zhang, Ken Cham-Fai Leung, Lijian Jin
Severe gum disease (periodontitis), which is one of the major global oral diseases, results from microbe-host dysbiosis and dysregulated immuno-inflammatory responses. It seriously affects oral health and general wellbeing with significant socio-economic implications. It has been well documented that natural flavonoids such as baicalin (BA) and baicalein (BE) possess potent anti-inflammatory effects. However, their intrinsic poor solubility and low bioavailability severely limit their biomedical applications...
June 26, 2017: Nanoscale
https://www.readbyqxmd.com/read/28648075/synergistic-effects-of-gold-palladium-nanoalloys-and-reducible-supports-on-the-catalytic-reduction-of-4-nitrophenol
#2
Ndzondelelo Bingwa, Rapelang Patala, Jihyang Noh, Matumuene Joe Ndolomingo, Siyamthanda Tetyana, Semakaleng Bewana, Reinout Meijboom
Herein we report on the catalytic activity of mesoporous nickel, iron, cerium, cobalt and manganese oxides prepared using KIT-6 as a hard-template via evaporation assisted precipitation. The mesoporous metal oxides (MMOs) were characterized and used as heterogeneous catalysts in the reduction of 4-nitrophenol (4-Nip) by sodium borohydride (〖BH〗_4^-). Furthermore, polyamidoamide (PAMAM) dendrimers were used to synthesize Gold-Palladium nanoalloy particles. The size of AuPd/PAMAM was found to be 3.5 ± 0...
June 24, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28646718/reduced-graphene-oxide-functionalized-feooh-for-signal-on-photoelectrochemical-sensing-of-prostate-specific-antigen-with-bioresponsive-controlled-release-system
#3
Qian Zhou, Youxiu Lin, Jian Shu, Kangyao Zhang, Zhenzhong Yu, Dianping Tang
A new and signal-on photoelectrochemical (PEC) sensing platform was successfully designed for the sensitive detection of prostate-specific antigen (PSA), using reduced graphene oxide- functionalized iron oxyhydroxide (FeOOH-rGO) as the photoactive material, accompanying target-responsive controlled release system to achieve the signal amplification. Introduction of rGO as electron mediator greatly facilitated the electron transfer from FeOOH to electrode under visible light, which inhibited the electron-hole recombination to enhance the photo-activity of FeOOH-rGO...
June 16, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28646143/a-comparison-between-sphere-and-rod-nanoparticles-regarding-their-in-vivo-biological-behavior-and-pharmacokinetics
#4
Yating Zhao, Yu Wang, Fu Ran, Yu Cui, Chang Liu, Qinfu Zhao, Yikun Gao, Da Wang, Siling Wang
In recent years, spherical nanoparticles has been studied extensively on biomedical applications including bioimaging and biosensing, diagnostics and theranostics, but the effect of the shape of nanoparticles has received little attention. In the present study, we designed three different shaped fluorescent mesoporous silica nanoparticles (MSNs), long rod nanoparticles (NLR), short rod nanoparticles (NSR), and spherical nanoparticles (NS) to systematically examine their behavior in vivo after oral administration...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28644614/role-of-the-protein-corona-derived-from-human-plasma-in-cellular-interactions-between-nanoporous-human-serum-albumin-particles-and-endothelial-cells
#5
Mikhail Valeryevich Zyuzin, Yan Yan, Raimo Hartmann, Katelyn T Gause, Moritz Nazarenus, Jiwei Cui, Frank Caruso, Wolfgang J Parak
The presence of a protein corona on various synthetic nanomaterials has been shown to strongly influence how they interact with cells. However, it is unclear if the protein corona also exists on protein particles, and if so, its role in particle-cell interactions. In this study, pure human serum albumin (HSA) particles were fabricated via mesoporous silica particle templating. Our data reveal that various serum proteins adsorbed on the particles. The presence of a corona from human plasma was shown to decrease particle binding to cell membrane, increase the residence time of particles in early endosomes, and reduce the amount of internalized particles within the first hours of cell exposure to particles...
June 23, 2017: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/28640597/positive-charge-functionalized-mesoporous-silica-nanoparticles-as-nanocarriers-for-controlled-2-4-dichlorophenoxy-acetic-acid-sodium-salt-release
#6
Lidong Cao, Zhaolu Zhou, Shujun Niu, Chong Cao, Xiuhuan Li, Yongpan Shan, Qiliang Huang
Due to its relatively high water solubility and mobility, 2,4-dichlorophenoxy acetic acid (2,4-D) has a high leaching potential threatening the surface water and groundwater. Controlled release formulations of 2,4-D could alleviate the adverse effects on the environment. In the present study, positive-charge functionalized mesoporous silica nanoparticles (MSNs) were facilely synthesized by incorporating trimethylammonium (TA) groups onto MSNs via a post-grafting method. 2,4-D sodium salt, the anionic form of 2,4-D, was effectively loaded into these positively charged MSN-TA nanoparticles...
June 22, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28640197/mesoporous-silica-matrix-as-a-tool-for-minimizing-dipolar-interactions-in-nife%C3%A2-o%C3%A2-and-znfe%C3%A2-o%C3%A2-nanoparticles
#7
Maider Virumbrales, Regino Saez-Puche, María José Torralvo, Veronica Blanco-Gutierrez
NiFe₂O₄ and ZnFe₂O₄ nanoparticles have been prepared encased in the MCM (Mobile Composition of Matter) type matrix. Their magnetic behavior has been studied and compared with that corresponding to particles of the same composition and of a similar size (prepared and embedded in amorphous silica or as bare particles). This study has allowed elucidation of the role exerted by the matrix and interparticle interactions in the magnetic behavior of each ferrite system. Thus, very different superparamagnetic behavior has been found in ferrite particles of similar size depending on the surrounding media...
June 22, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28635290/bare-and-effective-charge-of-mesoporous-silica-particles
#8
Sabrina Valetti, Adam Feiler, Martin Trulsson
We develop and combine a novel numerical model, within the Poisson-Boltzmann frame- work, with classical experimental titration techniques for mesoporous silica particles to study the charging behavior as both pH and the amount of monovalent salt are varied. One key finding is that these particles can be considered to have an effectively or apparent electroneutral inner core with an effectively charged rim. As a consequence, the total apparent charge of the particle is several orders of magnitude smaller than that of the bare silica charge, which accounts only for the charged silanol groups of the mesoporous silica particles and which has its major contribution from the interior...
June 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28635285/triazole-triazine-functionalized-mesoporous-silica-as-a-hybrid-material-support-for-palladium-nanocatalyst
#9
Ali Saad, Christian Vard, Manef Abderrabba, Mohamed Mehdi Chehimi
Noble and precious metal catalysts are sought for their remarkable efficiency in catalyzing numerous reactions in heterogeneous phase. However, they are costly and request the development of high surface area supports that favor their strong immobilization, dispersion and stability. Towards this end, mesoporous silica-based materials can be regarded as unique supports for nanometric-sized noble metal catalysts provided they are functionalized with appropriate ligands. In this work, mesoporous silica SBA-15 was prepared and modified with 3-azidopropyltriethoxysilane then clicked with alkyne derivatives of 1,3,5-triazines complex ligand...
June 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28632386/synthesis-of-hierarchically-structured-hybrid-materials-by-controlled-self-assembly-of-metal-organic-framework-with-mesoporous-silica-for-co2-adsorption
#10
Chong Chen, Bingxue Li, Lijin Zhou, Zefeng Xia, Nengjie Feng, Jing Ding, Lei Wang, Hui Wan, Guofeng Guan
The HKUST-1@SBA-15 composites with hierarchical pore structure were constructed by in situ self-assembly of metal-organic framework (MOF) with mesoporous silica. The structure directing role of SBA-15 had an obvious impact on the growth of MOF crystals, which in turn affected the morphologies and structural properties of the composites. The pristine HKUST-1 and the composites with different contents of SBA-15 were characterized by XRD, N2 adsorption-desorption, SEM, TEM, FT-IR, TG, XPS, and CO2-TPD techniques...
June 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28631822/mesoporous-silica-based-dosage-forms-improve-bioavailability-of-poorly-soluble-drugs-in-pigs-case-example-fenofibrate
#11
Joseph P O'Shea, Kalpa Nagarsekar, Alena Wieber, Vanessa Witt, Elisabeth Herbert, Caitriona M O'Driscoll, Christoph Saal, Dieter Lubda, Brendan T Griffin, Jennifer B Dressman
OBJECTIVES: Mesoporous silicas (SLC) have demonstrated considerable potential to improve bioavailability of poorly soluble drugs by facilitating rapid dissolution and generating supersaturation. The addition of certain polymers can further enhance the dissolution of these formulations by preventing drug precipitation. This study uses fenofibrate as a model drug to investigate the performance of an SLC-based formulation, delivered with hydroxypropyl methylcellulose acetate succinate (HPMCAS) as a precipitation inhibitor, in pigs...
June 20, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28631795/assembly-of-dicobalt-and-cobalt-aluminum-oxide-clusters-on-metal-organic-framework-and-nanocast-silica-supports
#12
Sai Puneet Desai, Camille D Malonzo, Thomas Webber, Jiaxin Duan, Anthony B Thompson, Stephen J Tereniak, Matthew R DeStefano, Cassandra T Buru, Zhanyong Li, R Lee Penn, Omar K Farha, Joseph T Hupp, Andreas Stein, Connie C Lu
NU-1000, a mesoporous metal-organic framework (MOF) featuring hexazirconium oxide nodes and 3 nm wide channels, was infiltrated with a reactive dicobalt complex to install dicobalt active sites onto the MOF nodes. The anchoring of the dicobalt complex onto NU-1000 occurred with a nearly ideal stoichiometry of one bimetallic complex per node and with the cobalt evenly distributed throughout the MOF particle. To access thermally robust multimetallic sites on an all-inorganic support, the modified NU-1000 materials containing either the dicobalt complex, or an analogous cobalt-aluminum species, were nanocast with silica...
June 20, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28629086/enhancing-internalization-of-silica-particles-in-myocardial-cells-through-surface-modification
#13
Nancy Ornelas-Soto, Rodrigo Rubio-Govea, Carlos E Guerrero-Beltrán, Eduardo Vázquez-Garza, Judith Bernal-Ramírez, Alejandra García-García, Yuriana Oropeza-Almazán, Gerardo García-Rivas, Flavio F Contreras-Torres
Surface modification in nanostructured mesoporous silica particles (MSNs) can significantly increase the uptake in myocardial cells. Herein, MSNs particles were synthesized and chemically functionalized to further assess their biocompatibility in rat myocardial cell line H9c2. The surface modification resulted in particles with an enhanced cellular internallization (3-fold increase) with respect to pristine particles. Apoptosis events were not evident at all, while necrosis incidence was significant only at a higher doses (>500μg/mL)...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629058/photo-induced-surface-grafting-of-phosphorylcholine-containing-copolymers-onto-mesoporous-silica-nanoparticles-for-controlled-drug-delivery
#14
Liucheng Mao, Meiying Liu, Long Huang, Dazhuang Xu, Qing Wan, Guangjian Zeng, Yanfeng Dai, Yuanqing Wen, Xiaoyong Zhang, Yen Wei
Surface modification of mesoporous silica nanoparticles (MSNs) with functional polymers has become one of the most interest topics over the last decade. Among various surface modification strategies, surface-initiated atom transfer radical polymerization (ATRP) has been regarded as one of the most effective methods. However, the typical ATRP strategy is relied on the transition metal ions and their organic ligands as the polymerization catalyst systems. In this work, a novel surface-initiated ATRP method was established for surface functionalization of MSNs using 10-Phenylphenothiazine (PTH) as the catalyst, 2-methacryloyloxyethyl phosphorylcholine (MPC) and itaconic acid (IA) as the monomers...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629031/near-infrared-persistent-luminescence-phosphors-znga-2-o-4-cr-3-as-an-accurately-tracker-to-photothermal-therapy-in-vivo-for-visual-treatment
#15
Hongbin Chen, Bin Zheng, Chao Liang, Li Zhao, Ying Zhang, Huizhuo Pan, Wanying Ji, Xiaoqun Gong, Hanjie Wang, Jin Chang
The photothermal therapy agents induced by 808 nm near infrared light laser have good potential for photothermal therapy (PTT) in vivo, with the advantages of harmless treatment, minimally invasion, high efficiency and deep tissue penetration. For the traditional photothermal therapy agents, however, it was impossible to track them in vivo because of the low signal-to-noise ratio, so we cannot conduct the extra near infrared light laser to radiate tumors sites accurately. Herein, we introduce a new complex: indocyanine green (ICG), near-infrared persistent luminescence (PL) phosphors ZnGa2O4:Cr(3+) (ZGC) and mesoporous silica nanoparticles (MSNs) (ICG@mZGC nanoparticles) were assembled for long-lasting optical imaging to guide PTT...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28629007/upconverting-and-persistent-luminescent-nanocarriers-for-accurately-imaging-guided-photothermal-therapy
#16
Peiqi Zhao, Wei Ji, Shiyong Zhou, Lihua Qiu, Lanfang Li, Zhengzi Qian, Xianming Liu, Huilai Zhang, Xuchen Cao
The fluorescence-guided photothermal therapy (FPTT) has great potential in cancer treatment. However, the conventional FPTT has to be stimulated by external light, which tends to increase background noise and leads to the inaccurate infrared light irradiation for PTT. In this study, upconverting and persistent luminescent nanocarriers (UPLNs) loaded mesoporous silica nanoparticles (UPLNs@mSiO2) were first designed to solve the problem mentioned above. The UPLNs cores can effectively reduce the short-lived autofluorescence interference by exerting the delay time between signal acquisition and pulsed excitation light...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628246/heterogeneous-catalysis-in-zeolites-mesoporous-silica-and-metal-organic-frameworks
#17
REVIEW
Jie Liang, Zibin Liang, Ruqiang Zou, Yanli Zhao
Crystalline porous materials are important in the development of catalytic systems with high scientific and industrial impact. Zeolites, ordered mesoporous silica, and metal-organic frameworks (MOFs) are three types of porous materials that can be used as heterogeneous catalysts. This review focuses on a comparison of the catalytic activities of zeolites, mesoporous silica, and MOFs. In the first part of the review, the distinctive properties of these porous materials relevant to catalysis are discussed, and the corresponding catalytic reactions are highlighted...
June 19, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28626793/acidic-ph-targeted-chitosan-capped-mesoporous-silica-coated-gold-nanorods-facilitate-detection-of-pancreatic-tumors-via-multispectral-optoacoustic-tomography
#18
Matthew R Zeiderman, Desiree E Morgan, John D Christein, William E Grizzle, Kelly M McMasters, Lacey R McNally
We present a cancer nanomedicine based on acidic pH targeted gold nanorods designed for multispectral optoacoustic tomography (MSOT). We have designed gold nanorods coated with mesoporous silica and subsequently capped with chitosan (CMGs). We have conjugated pH-sensitive variant 7 pHLIP peptide to the CMGs (V7-CMG) to provide targeting specificity to the acidic tumor microenvironment. In vitro, treatment of S2VP10 and MiaPaca2 cells with V7-CMG containing gemcitabine resulted in significantly greater cytotoxicity with 97% and 96...
July 11, 2016: ACS Biomaterials Science & Engineering
https://www.readbyqxmd.com/read/28625724/the-binary-system-of-ibuprofen-nicotinamide-under-nanoscale-confinement-from-cocrystal-to-coamorphous-state
#19
Yanping Bi, Deli Xiao, Shuai Ren, Shuyan Bi, Jianzhu Wang, Fei Li
Coamorphous systems have gained success in stabilizing amorphous drugs and improving their solubility and dissolution. Here we proposed to confine a binary mixture of drug and coformer (CF) within nanopores to obtain a nano-confined coamorphous (NCA) system. For proving feasibility of this proposal, a poorly water-soluble drug (ibuprofen, IBP) and a frequently used pharmaceutical CF (nicotinamide, NIC) were loaded into nanopores of mesoporous silica microspheres (MSMs). The solid state of NCA system was characterized by differential scanning calorimetry, X-ray powder diffraction, infrared spectrum and solid state nuclear magnetic resonance...
June 15, 2017: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28625001/nanostructured-sba-15-host-applied-in-ketorolac-tromethamine-release-system
#20
Jorgelina Cussa, Juliana M Juárez, Marcos B Gómez Costa, Oscar A Anunziata
The ordered mesoporous silica SBA-15 has been applied in studies of ketorolac tromethamine adsorption and release. The SBA-15 materials with hexagonal and regular structure were obtained using a triblock copolymer Pluronic P123 as a template and TEOS as a silica source. Ketorolac tromethamine was adsorbed into SBA-15 silica nanochannels using ethanol as solvent. The physicochemical and textural properties of SBA-15 and ketorolac tromethamine/SBA-15 were characterized by X-ray diffraction, thermogravimetric analysis, transmission electron microscopy, fourier transform infrared spectroscopy and BET surface studies...
August 2017: Journal of Materials Science. Materials in Medicine
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