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Mesoporous silica

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https://www.readbyqxmd.com/read/29345945/chitosan-silica-hybrid-composites-for-removal-of-sulfonated-azo-dyes-from-aqueous-solutions
#1
Magdalena Blachnio, Tetyana M Budnyak, Anna Derylo-Marczewska, Adam W Marczewski, Valentin A Tertykh
In this study, the influence of chitosan immobilization method on properties of final hybrids materials was performed. Chitosan immobilized on the surface of mesoporous (ChS2) and fumed silica (ChS3) by physical adsorption and through sol-gel method (ChS1). It was found that physical immobilization of chitosan allow to obtain hybrid composites (ChS) with homogeneous distribution of polymer on the surface, relatively wide pores and specific surface area about 170 m2/g, pHPZC=5.7 for ChS3 and 356 m2/g, pHPZC=6...
January 18, 2018: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29345456/pre-occupation-of-empty-carriers-decreases-endo-lysosome-escape-and-reduces-the-protein-delivery-efficiency-of-mesoporous-silica-nanoparticles
#2
Wenqing Li, Liping Sun, Yiqiu Xia, Si-Jie Hao, Gong Cheng, Zhigang Wang, Yuan Wan, Chuandong Zhu, Hongzhang He, Si-Yang Zheng
Endo/lysosome escape is a major challenge in nanoparticles-based protein delivery for cancer therapy. To enhance endo/lysosomal escape and increase the efficacy of proteins delivery, current strategies mainly focuses on destroying endo/lysosomes by employing modified nanoparticles, such as pH-sensitive polyplexes, cell-penetrating peptides, and photosensitive molecules. Herein, we hypothesize that pre-treatment with empty nanocarriers might make endo/lysosomes occupied and affect the endo/lysosomal escape of subsequent protein delivery by nanocarriers...
January 18, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29345434/two-photon-excited-silica-and-organosilica-nanoparticles-for-spatiotemporal-cancer-treatment
#3
REVIEW
Jonas G Croissant, Jeffrey I Zink, Laurence Raehm, Jean-Olivier Durand
Coherent two-photon-excited (TPE) therapy in the near-infrared (NIR) provides safer cancer treatments than current therapies lacking spatial and temporal selectivities because it is characterized by a 3D spatial resolution of 1 µm3 and very low scattering. In this review, the principle of TPE and its significance in combination with organosilica nanoparticles (NPs) are introduced and then studies involving the design of pioneering TPE-NIR organosilica nanomaterials are discussed for bioimaging, drug delivery, and photodynamic therapy...
January 18, 2018: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29344297/mesoporous-carbon-nanospheres-as-a-multifunctional-carrier-for-cancer-theranostics
#4
Libo Zhou, Ying Jing, Yubin Liu, Zhihe Liu, Duyang Gao, Haobin Chen, Weiye Song, Tao Wang, Xiaofeng Fang, Weiping Qin, Zhen Yuan, Sheng Dai, Zhen-An Qiao, Changfeng Wu
Optical nanomaterials with intense absorption in near-infrared (NIR) region hold great promise for biomedical applications such as photothermal therapy (PTT) and photoacoustic imaging (PAI). In this work, we report mesoporous carbon nanospheres (Meso-CNs) with broadband and intense absorption in the UV-Vis-NIR region (300-1400 nm) and explore their potential as a multifunctional platform for photoacoustic imaging and chemo-photothermal therapy. Methods: Meso-CNs were prepared by a "silica-assisted" synthesis strategy and characterized by transmission electron microscope and optical spectroscopy...
2018: Theranostics
https://www.readbyqxmd.com/read/29343957/codelivery-of-doxorubicin-and-mdr1-sirna-by-mesoporous-silica-nanoparticles-polymerpolyethylenimine-to-improve-oral-squamous-carcinoma-treatment
#5
Dandan Wang, Xiaowei Xu, Kai Zhang, Bin Sun, Lu Wang, Lin Meng, Qilin Liu, Changyu Zheng, Bai Yang, Hongchen Sun
Oral cancer is a type of head and neck cancer that is the seventh most frequent cancer and the ninth most frequent cause of death globally. About 90% of oral cancer is of squamous cell carcinoma type. Surgery and radiation with and without chemotherapy are the major treatments for oral cancer. Better advanced treatment is still needed. Multidrug resistance plays an important role in failure of oral cancer chemotherapy. In this study, we tried to fabricate a novel nanoparticle that could carry both MDR1-siRNA to block MDR1 expression and doxorubicin (DOX), a chemotherapy drug, into cancer cells in order to directly kill the cells with little or no effect of multidrug resistance...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29343865/targeting-murine-leukemic-stem-cells-by-antibody-functionalized-mesoporous-silica-nanoparticles
#6
Tamoghna Mandal, Michaela Beck, Nicole Kirsten, Mika Lindén, Christian Buske
Acute leukemia is initiated and maintained by leukemia stem cells (LSCs) and therefore there is great interest to develop innovative therapeutic approaches which target LSCs. Here we show that mesoporous silica nanoparticles (MSNs) functionalized with succinic anhydride, tagged with an anti-B220 antibody and loaded with the anthracycline daunorubicin are efficiently incorporated into murine B220-positive AML LSCs and preferentially kill these cells in comparison to B220-negative AML LSCs in vitro. Furthermore, short - term treatment of the AML LSCs with these MSNs before transplant significantly delayed leukemia development in recipient mice...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29343729/drug-self-assembly-for-synthesis-of-highly-loaded-antimicrobial-drug-silica-particles
#7
Cameron A Stewart, Yoav Finer, Benjamin D Hatton
Antimicrobial drug release from biomaterials for orthopedic repair and dental restorations can prevent biofilm growth and caries formation. Carriers for drug incorporation would benefit from long-term drug storage, controlled release, and structural stability. Mesoporous silica, synthesized through a co-assembly of silica and surfactant template, is an ideal drug encapsulation scaffold that maintains structural integrity upon release. However, conventional loading of drug within meso-silica pores via concentration-gradient diffusion limits the overall payload, concentration uniformity, and drug release control...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29340980/facile-synthesis-of-chitosan-capped-mesoporous-silica-nanoparticles-a-ph-responsive-smart-delivery-platform-for-raloxifene-hydrochloride
#8
Priya V Shah, Sadhana J Rajput
An encapsulation of model drug raloxifene hydrochloride (RAL) inside the chitosan decorated pH responsive mesoporous system has a greater potential for accumulating in the tumor cells. The present study involves synthesis of surface modified mesoporous silica nanoparticles (MSN) with the aim of achieving pH sensitive drug delivery system. A silanol skeleton of MSN has been productively modified to amine intermediate which served as a firm platform to adapt chitosan grafted assembly and systematically evaluated...
January 16, 2018: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29339186/uptake-and-intracellular-fate-of-cholera-toxin-subunit-b-modified-mesoporous-silica-nanoparticle-supported-lipid-bilayers-aka-protocells-in-motoneurons
#9
Maria A Gonzalez Porras, Paul Durfee, Sebastian Giambini, Gary C Sieck, C Jeffrey Brinker, Carlos B Mantilla
Cholera toxin B (CTB) modified mesoporous silica nanoparticle supported lipid bilayers (CTB-protocells) are a promising, customizable approach for targeting therapeutic cargo to motoneurons. In the present study, the endocytic mechanism and intracellular fate of CTB-protocells in motoneurons was examined to provide information for the development of therapeutic application and cargo delivery. Pharmacological inhibitors elucidated CTB-protocells endocytosis to be dependent on the integrity of lipid rafts and macropinocytosis...
January 12, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29338195/mesoporous-silica-thin-films-for-improved-electrochemical-detection-of-paraquat
#10
Tauqir Nasir, Gregoire Herzog, Marc Hebrant, Christelle Despas, Liang Liu, Alain Walcarius
An electrochemical method was developed for rapid and sensitive detection of the herbicide paraquat in aqueous samples using mesoporous silica thin film modified glassy carbon electrodes (GCE). Vertically-aligned mesoporous silica thin films were deposited onto GCE by electrochemically assisted self-assembly (EASA). Cyclic voltammetry revealed effective response to the cationic analyte (while rejecting anions) thanks to the charge selectivity exhibited by the negatively-charged mesoporous channels. Square wave voltametry (SWV) was then used to detect paraquat via its one electron reduction process...
January 17, 2018: ACS Sensors
https://www.readbyqxmd.com/read/29337422/hollow-mesoporous-silica-metal-organic-framework-and-its-applications-for-ph-responsive-doxorubicin-drug-delivery
#11
Xiaomin Jia, Zhiyuan Yang, Yujun Wang, Ya Chen, Haitao Yuan, Heyin Chen, Xiaoxiang Xu, Xueqing Gao, Zuozhong Liang, Yu Sun, Jian-Rong Li, Haoquan Zheng, Rui Cao
Metal-organic frameworks (MOFs), a new type of porous crystalline materials, have great potential in biomedical applications, such as drug delivery. However, the efficacy of drug delivery is limited by the low loading of drugs. We have synthesized hollow mesoporous silica (HMS)@MOF capsule that can be used as pH-responsive drug delivery system for anti-cancer drug doxorubicin (DOX). DOX is loaded into the inner cavity of HMS.Then, zeolitic imidazolate framework-8 (ZIF-8) nanoparticles are coated on the outer surface of DOX loaded HMS...
January 16, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29336808/miniaturized-solid-phase-extraction-of-macrolide-antibiotics-in-honey-and-bovine-milk-using-mesoporous-mcm-41-silica-as-sorbent
#12
Li-Jing Du, Ling Yi, Li-Hong Ye, Yu-Bo Chen, Jun Cao, Li-Qing Peng, Yu-Ting Shi, Qiu-Yan Wang, Yu-Han Hu
A simple and effective method of miniaturized solid-phase extraction (mini-SPE) was developed for the simultaneous purification and enrichment of macrolide antibiotics (MACs) (i.e. azithromycin, clarithromycin, erythromycin, lincomycin and roxithromycin) from honey and skim milk. Mesoporous MCM-41 silica was synthesized and used as sorbent in mini-SPE. Several key parameters affecting the performance of mini-SPE procedure were thoroughly investigated, including sorbent materials, amount of sorbent and elution solvents...
January 3, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29335172/preparation-of-amidoxime-functionalized-mesoporous-silica-nanospheres-ami-msn-from-coal-fly-ash-for-the-removal-of-u-vi
#13
Bangda Wang, Yuexi Zhou, Lei Li, Yi Wang
It is usually difficult to control the microstructure of mesoporous silica materials using coal fly ash as raw materials. In this study, amidoxime-functionalized mesoporous silica nanospheres (ami-MSN) were prepared from coal fly ash using a novel interfacial cohydrolysis-condensation method in an alkane-aqueous system. Characterizations suggested a regular microstructure, high specific surface area (676 m2/g) as well as stable and uniformly distributed amidoxime groups in the ami-MSN framework. Furthermore, ami-MSN displays a high U(VI) removal capacity in sorption experiments (98...
January 12, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29334793/controlled-synthesis-and-size-effects-of-multifunctional-mesoporous-silica-nanosystem-for-precise-cancer-therapy
#14
Bin Ma, Lizhen He, Yuanyuan You, Jianbin Mo, Tianfeng Chen
Nanomaterials-based drug delivery systems display potent applications in cancer therapy, owing to the enhanced permeability and retention effect and diversified chemical modification. In this study, we have tailored and synthesized different sized mesoporous silica nanoparticles (MSNs) through reactant control to investigate the relevancy of nanoparticle size toward anticancer efficacy and suppressing cancer multidrug resistance. The different sized MSNs loaded with anticancer ruthenium complex (RuPOP) and conjugated with folate acid (FA) to enhance the selectivity between cancer and normal cells...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29334396/towards-the-continuous-production-of-pt-based-heterogeneous-catalysts-using-microfluidic-systems
#15
Uson Laura, Manuel Arruebo, Victor Sebastian
The continuous production of Pt-based heterogeneous catalysts based on ultra-small (<2 nm) noble metal nanoparticles deposited on mesoporous ordered silica and their catalytic activity in VOC abatement are here reported. Microfluidic reactors can be used not only to enable the fast and controlled production of ultra-small Pt nanoparticles (NPs), but also alloyed NPs including PtPd, PtRu and PtRh can be formed in short residence times (between 60 s and 5 min). A novel continuous and homogeneous loading of these catalytic NPs on SBA-15 used as a mesoporous support is also here reported...
January 15, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29334370/scaffolds-that-mimic-antigen-presenting-cells-enable-ex-vivo-expansion-of-primary-t-cells
#16
Alexander S Cheung, David K Y Zhang, Sandeep T Koshy, David J Mooney
Therapeutic ex vivo T-cell expansion is limited by low rates and T-cell products of limited functionality. Here we describe a system that mimics natural antigen-presenting cells (APCs) and consists of a fluid lipid bilayer supported by mesoporous silica micro-rods. The lipid bilayer presents membrane-bound cues for T-cell receptor stimulation and costimulation, while the micro-rods enable sustained release of soluble paracrine cues. Using anti-CD3, anti-CD28, and interleukin-2, we show that the APC-mimetic scaffolds (APC-ms) promote two- to tenfold greater polyclonal expansion of primary mouse and human T cells compared with commercial expansion beads (Dynabeads)...
January 15, 2018: Nature Biotechnology
https://www.readbyqxmd.com/read/29323487/nanocoating-of-hydrophobic-mesoporous-silica-around-mil-101cr-for-enhanced-catalytic-activity-and-stability
#17
Jie Ying, Annika Herbst, Yu-Xuan Xiao, Hao Wei, Ge Tian, Zhaofei Li, Xiao-Yu Yang, Bao-Lian Su, Christoph Janiak
The metal-organic framework (MOF) MIL-101Cr was readily encapsulated by a very thin shell (around 30 nm) of hydrophobic mesoporous silica, which replicates the irregular shape of the MOF nanocrystals. Such a silica shell facilitates the diffusion of hydrophobic reactants with enhancement of the catalytic activity of the MOF and significantly improved catalytic stability of the MOF in the oxidation of indene.
January 11, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29323387/synergistic-effects-of-stellated-fibrous-mesoporous-silica-and-synthetic-dsrna-analogues-for-cancer-immunotherapy
#18
Xiupeng Wang, Xia Li, Atsuo Ito, Yu Sogo, Yohei Watanabe, Kaoru Hashimoto, Atsushi Yamazaki, Tadao Ohno, Noriko M Tsuji
Stellated fibrous mesoporous silica nanospheres significantly improve the cellular uptake of cancer antigen and the maturation of bone marrow derived dendritic cells in vitro. Moreover, the combination of poly(I:C) with stellated fibrous MS nanospheres markedly decreases the necessary dose of poly(I:C) for anti-tumor immunity, and thus opens new opportunities for the future clinical application of poly(I:C) in cancer immunotherapy.
January 11, 2018: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29319314/size-regulation-of-platinum-nanoparticles-by-using-confined-spaces-for-the-low-temperature-oxidation-of-ethylene
#19
Yu Kou, Lin-Bing Sun
Noble-metal nanoparticles have attracted great attention because of their excellent catalytic activity. However, the activity of noble-metal nanoparticles is severely dependent on the size of the metal nanoparticles. Therefore, regulation of the nanoparticle size is of great importance. Herein we report an efficient strategy for the first time to regulate the size of platinum (Pt) nanoparticles in a typical mesoporous silica SBA-15 by using the confined spaces. The Pt-containing precursor is introduced to the confined spaces between the template and silica walls in as-prepared SBA-15 by grinding...
January 10, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29319297/a-universal-low-temperature-process-for-preparation-of-multi-functional-high-performance-anti-reflective-mesoporous-silica-coatings-on-transparent-polymeric-substrates
#20
Ling Ai, Jing Zhang, Xiao Li, Yuehui Lu, Weijie Song
In this work, we developed a universal low-temperature process for the preparation of multi-functional and robust mesoporous silica anti-reflective coatings on transparent polymeric substrates. The mesoporous silica layer was formed after UV-O3 exposure and ammonia vapor treatment of dried poly (ethylene glycol)-block-poly (propylene glycol)-block-poly (ethylene glycol) (F127)-containing acidic silica gel. The optical and anti-scrubbing properties of the mesoporous silica coating were comparable to the coating prepared at 250 oC...
January 10, 2018: ACS Applied Materials & Interfaces
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