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Mesoporous silica

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https://www.readbyqxmd.com/read/29147000/stable-icg-loaded-upconversion-nanoparticles-silica-core-shell-theranostic-nanoplatform-for-dual-modal-upconversion-and-photoacoustic-imaging-together-with-photothermal-therapy
#1
Ruichan Lv, Depeng Wang, Liyang Xiao, Guanying Chen, Jun Xia, Paras N Prasad
We report here the design and multiple functions of a new hierarchical nanotheronostic platform consisting of an upconversion nanoparticle (UCNP) core: shell with an additional mesoporous silica (mSiO2) matrix load shell containing sealed, high concentration of ICG molecules. We demonstrate that this UCNP@mSiO2-ICG nanoplatform can perform the following multiple functions under NIR excitation at 800 nm: 1) Light harvesting by the UCNP shell containing Nd and subsequent energy transfer to Er in the Core to produce efficient green and red upconversion luminescence for optical imaging; 2) Efficient nonradiative relaxation and local heating produced by concentration quenching in aggregated ICG imbedded in the mesopourous silica shell to enable both photoacoustic imaging and photothermal therapy...
November 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29146540/temperature-sensitive-copolymer-coated-fluorescent-mesoporous-silica-nanoparticles-as-a-reactive-oxygen-species-activated-drug-delivery-system
#2
Feng Yu, Huijing Wu, Yao Tang, Yufang Xu, Xuhong Qian, Weiping Zhu
In this study, a temperature and ROS-responsive drug delivery system ROSP@MSN based on mesoporous silica nanoparticles has been designed and synthesized by taking advantage of 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl acrylate modified polymers (ROSP) as "nano-valve", which can respond selectively to cancer exclusive microenvironment and implement targeted drug release. Due to the superior temperature-sensitive properties of ROSP, ROSP@MSN could achieve cargo loading in cold water, and subsequently close the pore by raising temperature to obtain ROSP@MSN@DOX...
November 13, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29144310/preparation-of-ureido-functionalized-pva-silica-mesoporous-fibre-membranes-via-electrospinning-for-adsorption-of-pb-2-and-cu-2-in-wastewater
#3
Meimei Zhou, Weizhen Tang, Pingping Luo, Jiqiang Lyu, Aixia Chen, Longkai Qiao, Daniel Nover
Ureido-functionalized mesoporous polyvinyl alcohol/silica composite nanofibre membranes were prepared by electrospinning technology and their application for removal of Pb(2+) and Cu(2+) from wastewater was discussed. The characteristics of the membranes were investigated by scanning electron microscopy, transmission electron microscopy, X-ray diffraction, and N2 adsorption-desorption analysis. Results show that the membranes have long fibrous shapes and worm-like mesoporous micromorphologies. Fourier transform infrared spectroscopy confirmed the membranes were successfully functionalized with ureido groups...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29140684/janus-gold-nanoplatform-for-synergetic-chemoradiotherapy-and-computed-tomography-imaging-of-hepatocellular-carcinoma
#4
Zheng Wang, Dan Shao, Zhimin Chang, Mengmeng Lu, Yingshuai Wang, Juan Yue, Dian Yang, Mingqiang Li, Qiaobing Xu, Wen-Fei Dong
There is a pressing need to develop nanoplatforms that integrate multimodal therapeutics to improve treatment responses and prolong the survival of patients with unresectable hepatocellular carcinoma (HCC). Mesoporous silica-coated gold nanomaterials have emerged as a novel multifunctional platform combining tunable surface plasmon resonance and mesoporous properties that exhibit multimodality properties in cancer theranostics. However, their reduced radiation-absorption efficiency and limited surface area hinder their further radiochemotherapeutic applications...
November 17, 2017: ACS Nano
https://www.readbyqxmd.com/read/29140677/synthesis-of-multi-au-nanoparticles-embedded-mesoporous-silica-microspheres-as-self-filtering-and-reusable-substrates-for-sers-detection
#5
Miao Chen, Wen Luo, Zhimin Zhang, Ranhao Wang, Yuqiu Zhu, Hua Yang, Xiaoqing Chen
Surface-enhanced Raman scattering (SERS) based biosensing in biological fluids is constrained by nonspecific macromolecules adsorptions and disposable property of the SERS substrate. Here, novel multi-Au nanoparticles-embedded mesoporous silica microspheres (AuNPs/mSiO2) was prepared using a one-pot method, which served as reliable substrates for SERS enhancement associated with salient features of self-filtering ability and reusability. The fabrication and physical characterization of AuNPs/mSiO2 microspheres were discussed, and SERS activity of this novel substrates was investigated by using 4-mercaptobenzoic acid (4-MBA) as Raman probe...
November 15, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29139212/shape-controlled-surface-coating-to-pd-mesoporous-silica-core-shell-nanocatalysts-with-high-catalytic-activity-and-stability
#6
Jie Ying, Christoph Janiak, Yu-Xuan Xiao, Hao Wei, Xiao-Yu Yang, Bao-Lian Su
Cubic Pd nanocrystals with shape-controlled mesoporous silica shells have been theoretically designed and successfully synthesized for investigating the effect of a porous nanoshell on catalytic performance of the core. Cubic Pd@cubic mesoporous silica keeps activity of all facets and shows highest catalytic activity and enhanced reusability in the hydrogenation of nitrobenzene.
November 14, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29139206/periodically-arranged-arrays-of-dendritic-pt-nanospheres-using-cage-type-mesoporous-silica-as-a-hard-template
#7
Kenya Kani, Victor Malgras, Bo Jiang, Md Shahriar A Hossain, Saad M Alshehri, Tansir Ahamad, Rahul R Salunkhe, Zhenguo Huang, Yusuke Yamauchi
Dendritic Pt nanospheres of 20 nm diameter are synthesized by using highly concentrated surfactant assembly within the large-sized cage-type mesopores of mesoporous silica (LP-FDU-12). After diluting the surfactant solution with ethanol, the lower viscosity lead to an improved penetration inside the mesopores. After Pt deposition followed by template removal, the arrangement of the Pt nanospheres is a replication from that of the mesopores in the original LP-FDU-12 template. Although it is well known that ordered LLCs can form on flat substrates, confined space inside the mesopores hinders surfactant self-organization...
November 14, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29138772/mesoporous-silica-nanoparticles-incorporating-squaraine-based-photosensitizers-a-combined-experimental-and-computational-approach
#8
Ivana Miletto, Alberto Fraccarollo, Nadia Barbero, Claudia Barolo, Maurizio Cossi, Leonardo Marchese, Enrica Gianotti
Squaraine dyes, that exhibit intense absorption in the red/near infrared region, have been successfully introduced into mesoporous silica nanoparticles (MSNs) to obtain a nanoplatform for photodynamic therapy. Three brominated squaraine dyes which exhibited good PS performance in solution but a different behaviour in vitro due to cell permeability issues were used as photosensitizers. The effects of the adsorption within the pores of MSNs on the overall UV-Vis-NIR absorption and emission properties as well as on the PS performance was evaluated via a combined experimental and computational physico-chemical approach, which allowed us to correlate the unusual optical properties of two out of three systems with the dimerization of squaraines on the silica surface, with detrimental effects on the PS performance...
November 15, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29137786/sonochemical-synthesis-of-fe3o4-nh2-mesoporous-silica-polypyrrole-pd-a-core-double-shell-nanocomposite-for-catalytic-applications
#9
Youssef Snoussi, Stéphane Bastide, Manef Abderrabba, Mohamed M Chehimi
There is a growing interest in sonochemistry for either the controlled design of nanostructured materials or for the synthesis of polymers and polymer composites. It is fast and highly efficient method that provides materials with exceptional and enhanced structural and chemical properties. Herein, we take advantage of the versatile sonochemical process in order to design core/double layered shell nanocomposite denoted by Fe3O4@NH2-mesoporous silica@ PPy/Pd. This magnetic, multicomponent material was designed in a three-step sono-process: (i) synthesis of magnetic core, (ii) cure of mesoporous silica, and (iii) sonochemical deposition of PPy/Pd...
March 2018: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/29136866/flow-through-silica-a-potential-matrix-for-fast-chromatographic-enantioseparation-with-high-enantioselectivity
#10
Xiao-Jing Mao, Jing Li, Dan Liu, Ting Qiao, Liyun Ma, Xiao Sun, Li Xu, Zhi-Guo Shi
The demand for fast chromatographic enantioseparation aroused the hot research in stationary phase matrix. In the present study, the flow-through silica, which is characterized by hierarchical pores of through pores in several hundred nanometer range and mesopores about 20nm, was attempted for fast enantioseparation. Thanks to the large surface area and full openness of the through pores, the flow-through silica had comparable cellulose derivative loading amount as the commercial wide-pore silica, which was impracticable for most of the core-shell particles and sub-2-μm fully porous silica...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29136862/stimulus-response-click-chemistry-based-aptamer-functionalized-mesoporous-silica-nanoparticles-for-fluorescence-detection-of-thrombin
#11
Zhonghui Chen, Mi Sun, Fang Luo, Kefeng Xu, Zhenyu Lin, Lan Zhang
In most aptamer based stimulus response mesoporous silica nanoparticles (MSN) systems, the aptamer is modified on the MSN via electrostatic interaction, however leakage might exist after a certain time in the system and hence the stability is not good. In this study, the pores of MSN were capped by aptamer through click chemistry reaction for the first time and the system was then employed to develop a fluorescence biosensor. Specifically, the aptamer of the target (thrombin in this study) was hybridized with its complementary DNA (which was initially modified with alkyne at the terminal) to form a double strand DNA (dsDNA) firstly, and then this dsDNA was modified on N3 modified MSN via Cu(I) catalyzed alkyne-azide cycloaddition reaction...
February 1, 2018: Talanta
https://www.readbyqxmd.com/read/29131638/lipid-pore-filled-silica-thin-film-membranes-for-biomimetic-recovery-of-dilute-carbohydrates
#12
Shanshan Zhou, Daniel M Schlipf, Emma Caroline Guilfoil, Stephen E Rankin, Barbara Lynn Knutson
Selectively permeable biological membranes containing lipophilic barriers inspire the design of biomimetic carrier-mediated membranes for aqueous solute separation. The recovery of glucose, which can reversibly bind to boronic acid carriers, is examined in lipid pore-filled silica thin film composite membranes with accessible mesopores. The successful incorporation of lipids (1, 2-dipalmitoyl-sn-glycero-3-phosphocholine, DPPC) and boronic acid carriers ((4-(N-Boc-amino)methyl) phenylboronic acid, BAMP-BA) in the pores of a mesoporous silica (~10 nm pore diameter) through evaporation deposition is verified by confocal microscopy and differential scanning calorimetry (DSC)...
November 13, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29128843/shape-controlled-magnetic-mesoporous-silica-nanoparticles-for-magnetically-mediated-suicide-gene-therapy-of-hepatocellular-carcinoma
#13
Zheng Wang, Zhimin Chang, Mengmeng Lu, Dan Shao, Juan Yue, Dian Yang, Xiao Zheng, Mingqiang Li, Kan He, Ming Zhang, Li Chen, Wen-Fei Dong
Magnetic nanoparticles (NPs) have emerged as a promising tool for suicide gene therapy. However, the separate delivery of the suicide gene and prodrug in current systems limits their clinical translation. Therefore, improving magnetically mediated suicide gene therapy by exploring higher performance magnetic NP-based hybrid nanoplatforms is an important challenge. In the current study, shape-controlled magnetic mesoporous silica nanoparticles (M-MSNs) were prepared, and their performance in magnetic resonance imaging (MRI)-guided, magnetically targeted and hyperthermia-enhanced suicide gene therapy of hepatocellular carcinoma (HCC) was investigated...
November 4, 2017: Biomaterials
https://www.readbyqxmd.com/read/29128728/novel-synthesis-of-cyano-functionalized-mesoporous-silica-nanospheres-msn-from-coal-fly-ash-for-removal-of-toxic-metals-from-wastewater
#14
Bangda Wang, Yuexi Zhou, Lei Li, Hui Xu, Yinglong Sun, Yi Wang
Trace amounts of toxic metals are usually difficult to be purified by conventional chemical precipitation or physical adsorption in wastewater. In this study, in order to realize high-value utilization of coal fly ash for wastewater purification, a novel method was applied to prepare high-performance mesoporous silica materials from coal fly ash. In comparison with a commonly used method, characterizations revealed that the new method obtained mesoporous silica nanospheres with uniformly distributed cyano groups (denoted by MSN), while the common method only obtained irregular sponge-like microstructure (denoted by ISM)...
November 1, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29128658/mesoporous-silica-nanoparticles-a-smart-nanosystem-for-management-of-breast-cancer
#15
REVIEW
Neelam Poonia, Viney Lather, Deepti Pandita
Breast cancer is the second-leading cause of death in women worldwide owing to aggressive metastasis, lack of early diagnosis and poor access to treatment amenities. During the past decade, mesoporous silica nanoparticles (MSNs) have gained ground for the delivery of a wide variety of chemotherapeutic and bioimaging agents owing to their unique characteristics and straightforward fabrication methods. Present research studies based on MSNs have provided various potential insights in their applicability in breast cancer treatment by improving solubility and stability and decreasing the adverse effects of current treatment regimens...
November 8, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/29127069/lectin-conjugated-ph-responsive-mesoporous-silica-nanoparticles-for-targeted-bone-cancer-treatment
#16
Marina Martínez-Carmona, Daniel Lozano, Montserrat Colilla, María Vallet-Regí
A novel multifunctional nanodevice based in doxorubicin (DOX)-loaded mesoporous silica nanoparticles (MSNs) as nanoplatforms for the assembly of different building blocks has been developed for bone cancer treatment. These building blocks consists of: i) a polyacrylic acid (PAA) capping layer grafted to MSNs via an acid-cleavable acetal linker, to minimize premature cargo release and provide the nanosystem of pH-responsive drug delivery ability; and ii) a targeting ligand, the plant lectin concanavalin A (ConA), able to selectively recognize, bind and internalize owing to certain cell-surface glycans, such as sialic acids (SA), overexpressed in given tumor cells...
November 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29127064/multifunctional-ph-sensitive-3d-scaffolds-for-treatment-and-prevention-of-bone-infection
#17
Mónica Cicuéndez, Juan C Doadrio, Ana Hernández, M Teresa Portolés, Isabel Izquierdo-Barba, María Vallet-Regí
Multifunctional-therapeutic three-dimensional (3D) scaffolds have been prepared. These biomaterials are able to destroy the S. aureus bacterial biofilm and to allow bone regeneration at the same time. The present study is focused on the design of pH sensitive 3D hierarchical meso-macroporous 3D scaffolds based on MGHA nanocomposite formed by a mesostructured glassy network with embedded hydroxyapatite nanoparticles, whose mesopores have been loaded with levofloxacin (Levo) as antibacterial agent. These 3D platforms exhibit controlled and pH-dependent Levo release, sustained over time at physiological pH (7...
November 7, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29126959/nanocarriers-as-phototherapeutic-drug-delivery-system-appraisal-of-three-different-nanosystems-in-an-in-vivo-and-in-vitro-exploratory-study
#18
Eduardo Ricci-Junior, Luciana Betzler de Oliveira de Siqueira, Raphaela Aparecida Schuenck Rodrigues, Félix Sancenón, Ramón Martínez-Máñez, João Alfredo de Moraes, Ralph Santos-Oliveira
The use of nanosystem as diagnosing and therapy systems is increasing each year. There are several nanosystems available nowadays and the most prominent ones are: mesoporous silica, nanoemulsion and polymeric nanoparticles due to its characteristics, like low toxicology, and easy-producing process. They all have advantages when compared with the traditional system used, since they show specific targeting, controlled release, and higher penetration. In this study were tested three different nanocarriers (polymeric nanoparticles, nanoemulsion and mesoporous silica) containing phthalocyanineas possible PDT drugs (nanodrugs)...
November 7, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29124979/mesoporous-carbon-nanomaterials-in-drug-delivery-and-biomedical-application
#19
Qinfu Zhao, Yuanzhe Lin, Ning Han, Xian Li, Hongjian Geng, Xiudan Wang, Yu Cui, Siling Wang
Recent development of nano-technology provides highly efficient and versatile treatment methods to achieve better therapeutic efficacy and lower side effects of malignant cancer. The exploration of drug delivery systems (DDSs) based on nano-material shows great promise in translating nano-technology to clinical use to benefit patients. As an emerging inorganic nanomaterial, mesoporous carbon nanomaterials (MCNs) possess both the mesoporous structure and the carbonaceous composition, endowing them with superior nature compared with mesoporous silica nanomaterials and other carbon-based materials, such as carbon nanotube, graphene and fullerene...
2017: Drug Delivery
https://www.readbyqxmd.com/read/29124936/in-vivo-ct-photoacoustic-imaging-and-nir-triggered-chemo-photothermal-combined-therapy-based-on-a-gold-nanostar-mesoporous-silica-and-thermo-sensitive-liposomes-composited-nanoprobe
#20
Jie An, Xiao-Quan Yang, Kai Cheng, Xian-Lin Song, Lin Zhang, Cheng Li, Xiao-Shuai Zhang, Yang Xuan, Yuan-Yang Song, Bi-Yun Fang, Xiao-Lin Hou, Yuan-Di Zhao, Bo Liu
Safe multifunctional nanoplatforms that have multiple therapeutic functions integrated with imaging capabilities are highly desired for biomedical applications. In this paper, targeted chemo-photothermal synergistic therapy and photoacoustic/CT imaging of tumor were achieved by one novel multifunctional nanoprobe (GMS/DOX@SLB-FA), it was composed of gold nanostar core and doxorubicin (DOX) loading mesoporous silica shell (GMS), which was coated with folic acid (FA) modified thermosensitively supported lipid bilayer (FA-SLB) as gatekeeper...
November 10, 2017: ACS Applied Materials & Interfaces
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