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Mesoporous silica

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https://www.readbyqxmd.com/read/28449545/structural-variety-and-adsorptive-properties-of-mesoporous-silicas-with-immobilized-oligosaccharide-groups
#1
Iryna Trofymchuk, Nadiia Roik, Lyudmila Belyakova
In this research, we report on the synthesis of mesoporous silicas with various quantities of immobilized oligosaccharide groups and different pore ordering degree. The hydrothermal co-condensation of tetraethyl orthosilicate and β-cyclodextrin-containing organosilane in the presence of cetyltrimethylammonium bromide template was employed. The purpose of this investigation was to show the opportunity of increasing β-cyclodextrin content in silica matrix by changing the molar ratio of initial reagents during organosilane synthesis and to determine whether the enhancing of immobilized groups on the surface influences on model aromatic compound adsorption from water...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28449264/macroscopically-oriented-porous-materials-with-periodic-ordered-structures-from-zeolites-and-metal-organic-frameworks-to-liquid-crystal-templated-mesoporous-materials
#2
REVIEW
Joonil Cho, Yasuhiro Ishida
Porous materials with molecular-sized periodic structures, as exemplified by zeolites, metal-organic frameworks, or mesoporous silica, have attracted increasing attention due to their range of applications in storage, sensing, separation, and transformation of small molecules. Although the components of such porous materials have a tendency to pack in unidirectionally oriented periodic structures, such ideal types of packing cannot continue indefinitely, generally ceasing when they reach a micrometer scale...
April 27, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28444786/targeted-photodynamic-therapy-with-a-folate-sensitizer-assembly-produced-from-mesoporous-silica
#3
Salvatore Sortino, Chunfang Zhou, Damien Afonso, Sabrina Valetti, Adam Feiler, Venera Cardile, Adriana Graziano, Sabrina Conoci
A mesoporous silica material prepared by using folic acid (FA) as a template enables the effective encapsulation of meso-tetrakis(4-carboxyphenyl)porphyrin (TCPP) in its interior. Combination of steady-state and time-resolved absorption and emission spectroscopy demonstrate that FA and TCPP are released from the silica material to aqueous phase in the form of a non-covalent assembly. This assembly does not form by simple mixing of the two components in the absence of silica, suggesting the key role of the material in the assembling process...
April 26, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28443896/an-msn-peg-ip-drug-delivery-system-and-il13r%C3%AE-2-as-targeted-therapy-for-glioma
#4
Jinlong Shi, Shiqiang Hou, Jianfei Huang, Shanshan Wang, Wei Huan, Chuanjun Huang, Xiaojiang Liu, Rui Jiang, Wenbo Qian, Jingjing Lu, Xiubing Wang, Wei Shi, Rongqin Huang, Jian Chen
A combination of gene therapy and chemotherapy has recently received interest as a targeted therapy for glioma. A mesoporous silica nanoparticle (MSN)-based vehicle coated with IL13Rα2-targeted peptide (IP) using polyethylene glycol (PEG), MSN-PEG-IP (MPI), was constructed and confirmed as a potential glioma-targeted drug delivery system in vitro. In this work, tissue microarray (TMA) results revealed that IL13Rα2 was over-expressed in human glioma tissues and that high expression of IL13Rα2 in patients was associated with poor survival...
April 26, 2017: Nanoscale
https://www.readbyqxmd.com/read/28443884/monolithic-porous-magnesium-silicide
#5
N Hayati-Roodbari, R J F Berger, J Bernardi, S Kinge, N Hüsing, M S Elsaesser
Macroporous magnesium silicide monoliths were successfully prepared by a two-step synthesis procedure. The reaction of gaseous magnesium vapor with macro-/mesoporous silicon, which was generated from hierarchically organized meso-/macroporous silica by a magnesiothermic reduction reaction, resulted in monolithic magnesium silicide with a cellular, open macroporous structure. By adjusting the reaction conditions, such as experimental set-up, temperature and time, challenges namely loss of porosity or phase purity of Mg2Si were addressed and monolithic magnesium silicide with a cellular network builtup was obtained...
April 26, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28443502/fe3o4-sio2-kit-6-as-an-efficient-and-reusable-catalyst-for-the-synthesis-of-novel-derivatives-of-3-3-aryl-1-phenyl-1h-pyrazol-4-yl-methylene-bis-1h-indole
#6
Mohammad Nikpassand, Leila Zare Fekri, Mozhdeh Nabatzadeh
Korea advanced institute of science and technology cubic ordered mesoporous silica (KIT-6 mesoporous) silica coated magnetite nanoparticles, is an effective, eco-benign and recyclable catalyst for the electrophilic substitution reactions of indoles with various synthetized aldehydes to afford the corresponding novel diindolylmethanes in high yields and short reaction times. The catalyst can be recovered and reused without loss of activity. The work-up of the reaction consists of a simple separation, followed by concentration of the crude product and purification...
April 25, 2017: Combinatorial Chemistry & High Throughput Screening
https://www.readbyqxmd.com/read/28442903/magnetic-and-ph-dual-responsive-mesoporous-silica-nanocomposites-for-effective-and-low-toxic-photodynamic-therapy
#7
Jieqiong Zhan, Zhiqiang Ma, Dan Wang, Xinfang Li, Xiangui Li, Lijing Le, Anfeng Kang, Pengwei Hu, Lan She, Feng Yang
Nonspecific targeting, large doses and phototoxicity severely hamper the clinical effect of photodynamic therapy (PDT). In this work, superparamagnetic Fe3O4 mesoporous silica nanoparticles grafted by pH-responsive block polymer polyethylene glycol-b-poly(aspartic acid) (PEG-b-PAsp) were fabricated to load the model photosensitizer rose bengal (RB) in the aim of enhancing the efficiency of PDT. Compared to free RB, the nanocomposites (polyethylene glycol-b-polyaspartate-modified rose bengal-loaded magnetic mesoporous silica [RB-MMSNs]) could greatly enhance the cellular uptake due to their effective endocytosis by mouse melanoma B16 cell and exhibited higher induced apoptosis although with little dark toxicity...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28441616/core-shell-hierarchical-mesostructured-silica-nanoparticles-for-gene-chemo-synergetic-stepwise-therapy-of-multidrug-resistant-cancer
#8
Lijun Sun, Dangge Wang, Yu Chen, Liying Wang, Ping Huang, Yaping Li, Ziwei Liu, Heliang Yao, Jianlin Shi
The design and synthesis of hierarchically nanoporous structures for the co-encapsulation and sequential releases of different cargos are still great challenges in biomedical applications. In this work, we report on the elaborate design and controlled synthesis of a unique core-shell hierarchical mesoporous silica/organosilica nanosystem, in which there are large and small mesopores separately present in the shell and core, facilitating the independent encapsulations of large (siRNA) and small (doxorubicin) molecules, respectively...
April 18, 2017: Biomaterials
https://www.readbyqxmd.com/read/28440642/asymmetric-silica-nanoparticles-with-tunable-head-tail-structures-enhance-hemocompatibility-and-maturation-of-immune-cells
#9
Prasanna Lakshmi Abbaraju, Anand Kumar Meka, Hao Song, Yannan Yang, Manasi Jambhrunkar, Jun Zhang, Chun Xu, Meihua Yu, Chengzhong Yu
Asymmetric mesoporous silica nanoparticles (MSN) with controllable head-tail structures have been successfully synthesized. The head particle type is tunable (solid or porous) and the tail has dendritic large pores. The tail length and tail coverage on head particles are adjustable. Compared to spherical silica nanoparticles with a solid structure (Stöber spheres) or large-pore symmetrical MSN with fully covered tails, asymmetrical head-tail MSN (HTMSN) show superior hemocompatibility due to reduced membrane deformation of red blood cells and decreased level of reactive oxygen species...
April 25, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28437111/mesostructure-of-mesoporous-silica-anodic-alumina-hierarchical-membranes-tuned-with-ethanol
#10
Silo Meoto, Niall Kent, Michael M Nigra, Marc-Olivier Coppens
Hierarchically structured membranes composed of mesoporous silica embedded inside the channels of anodic alumina (MS-AAM) were synthesized using the aspiration method. Ethanol is shown to have a significant effect on the type and organization of the mesoporous silica phase. Detailed textural analysis revealed that the pore size distribution of the mesoporous silica narrows and the degree of ordering increases, with decreasing ethanol concentration used in the synthesis mixture. The silica mesopores were synthesized with pores as small as 6 nm in diameter, with the channel direction oriented in lamellar, circular and columnar directions, depending on the ethanol content...
April 24, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28437093/a-pathogen-specific-cargo-delivery-platform-based-on-mesoporous-silica-nanoparticles
#11
Bastian Ruehle, Daniel L Clemens, Bai-Yu Lee, Marcus A Horwitz, Jeffrey I Zink
We present a synthetic approach to a highly pathogen-selective detection and delivery platform based on the in-teraction of an antibody nanovalve with a tetrasaccharide from the O-Antigen of the lipopolysaccharide of Francisella tularensis bacteria, a Tier 1 Select Agent of bioterrorism. Different design considerations are explored, and proof-of-concept for highly pathogen-specific cargo release from mesoporous silica nanoparticles is demonstrated by comparisons of the release of a signal transducer and model drug by LPS from Francisella tularensis vs...
April 24, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28436505/well-defined-functional-mesoporous-silica-polymer-hybrids-prepared-by-an-icar-atrp-technique-integrated-with-bio-inspired-polydopamine-chemistry-for-lithium-isotope-separation
#12
Yuekun Liu, Xuegang Liu, Gang Ye, Yang Song, Fei Liu, Xiaomei Huo, Jing Chen
Mesoporous silica/polymer hybrids with well-preserved mesoporosity were prepared by integrating the initiators for continuous activator regeneration (ICAR) atom transfer radical polymerization (ATRP) technique with the bio-inspired polydopamine (PDA) chemistry. By manipulating the auto-oxidative polymerization of dopamine, uniform PDA layers were deposited on the surfaces and pore walls of ordered mesoporous silicas (OMSs), thereby promoting the immobilization of ATRP initiators. Poly(glycidyl methacrylate) (PGMA) brushes were then grown from the OMSs by using the ICAR ATRP technique...
April 24, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28432799/the-transformation-of-hybrid-silica-nanoparticles-from-solid-to-hollow-or-yolk-shell-nanostructures
#13
Xingwen Liu, Guangren Qian, Zheng Jiao, Minghong Wu, Haijiao Zhang
Here, a facile self-templating approach has been presented for synthesis of hollow and yolk-shell mesoporous silica nanoparticles (HMSNs and YMSNs) through a selective etching of hybrid silica nanoparticles. The hybrid silica nanoparticles are from the co-condensation of tetraethylorthosilicate (TEOS) and N-[3-(trimethoxysilyl)propyl]ethylenediamine (TSD) by a simple one-step process. Two kinds of products including HMSNs and YMSNs can be easily prepared only by tuning the TSD amounts in the precursor. Significantly, the transformation of hollow structure does not use any sacrificial template and surface protective agent...
April 22, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28431688/thermal-desorption-gas-chromatographic-methodology-for-the-determination-of-residual-solvents-in-mesoporous-silica
#14
Adissu Alemayehu Asfaw, Kris Wolfs, Ann Van Schepdael, Erwin Adams
In this work, thermal desorption-gas chromatography-flame ionization detection (TD-GC-FID) was adapted to enable the determination of residual solvents (RS) in mesoporous silica (MPSi). MPSi is often utilized in various pharmaceutical formulations or drug delivery systems and the accurate determination of RS is an important part of pharmaceutical quality control. Seven commonly used solvents (methanol, ethanol, acetone, isopropanol, dichloromethane, tetrahydrofuran and hexafluoroisopropanol) were evaluated in combination with 3 types of MPSi having pore sizes of 2-3, 15 and 25nm...
April 12, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/28429028/experimental-separation-steps-influence-the-protein-content-of-corona-around-mesoporous-silica-nanoparticles
#15
C Pisani, J C Gaillard, C Dorandeu, C Charnay, Y Guari, J Chopineau, J M Devoisselle, J Armengaud, O Prat
In order to direct nanocarriers to their targets efficiently, we have to understand the interactions occurring at the nano-bio interface between nanocarriers and human proteins, which forms the layer called the corona. However, experiments aiming to identify and quantify the proteins in the corona, especially critical steps in the separation of nanoparticles from biological media may affect the corona composition. Here, we used nano-LC MS/MS to compare the protein corona contents obtained after using two different separation methods...
April 21, 2017: Nanoscale
https://www.readbyqxmd.com/read/28425316/carbon-covered-mesoporous-silica-and-its-application-in-rhodamine-b-adsorption
#16
R C S Nascimento, A O S Silva, L Meili
Modified versions of MCM-41 and SBA-15 were obtained from sucrose by carbon deposition. The ability of the resulting materials, MCM-41 CC and SBA-15 CC, to remove Rhodamine B from aqueous solutions was evaluated. TG/DTG, XRD, Nitrogen Adsorption (BET), and SEM were used to characterize the materials. Adsorption was investigated by finite bath studies. To characterize the adsorption behavior and mechanism, kinetics and equilibrium were assessed. MCM-41 CC provided the best adsorption results: adsorptive capacity of 11...
April 20, 2017: Environmental Technology
https://www.readbyqxmd.com/read/28425291/dispersed-vanadium-in-three-dimensional-dendritic-mesoporous-silica-nanospheres-active-and-stable-catalysts-for-the-oxidative-dehydrogenation-of-propane-in-the-presence-of-co2
#17
Xu-Liang Xue, Wan-Zhong Lang, Xi Yan, Ya Jun Guo
The uniform monodispersed vanadium-doped three-dimensional dendritic mesoporous silica nanospheres (nV-MSNSs) were successfully synthesized in a heterogeneous oil-water biphase stratification reaction system, and characterized by several state-of-art methods. The synthesized nV-MSNSs were applied to the oxidative dehydrogenation of propane (ODHP) reaction with the presence of CO2 and exhibited excellent catalytic performances. The results show that the vanadium loading (1.3-8.0 wt %) evidently influences the textural properties, oxidation state and polymerization degree of vanadium species of nV-MSNSs...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28422506/extra-large-pore-mesoporous-silica-nanoparticles-for-directing-in-vivo-m2-macrophage-polarization-by-delivering-il-4
#18
Dohyeong Kwon, Bong Geun Cha, Yuri Cho, Jiyoun Min, Eun-Byeol Park, Suk-Jo Kang, Jaeyun Kim
Over the past decade, mesoporous silica nanoparticles (MSNs) smaller than 200 nm with a high colloidal stability have been extensively studied for systemic drug delivery. Although small molecule delivery via MSNs has been successful, the encapsulation of large therapeutic biomolecules, such as proteins or DNA, is limited due to small pore size of the conventional MSNs obtained by soft-templating. Here, we report the synthesis of mesoporous silica nanoparticles with extra-large pores (XL-MSNs) and their application to in vivo cytokine delivery for macrophage polarization...
April 24, 2017: Nano Letters
https://www.readbyqxmd.com/read/28422250/a-novel-nanomissile-targeting-two-biomarkers-and-accurately-bombing-ctcs-with-doxorubicin
#19
Yu Gao, Xiaodong Xie, Fengqiao Li, Yusheng Lu, Tao Li, Shu Lian, Yingying Zhang, Huijuan Zhang, Hao Mei, Lee Jia
Rare circulating tumor cells (CTCs) cause >50% of primary colorectal cancer survivors to develop deadly metastasis at 3-5 years after surgery; the current chemotherapies can do nothing about these cells. Herein, we synthesized a novel doxorubicin (DOX)-entrapped mesoporous silica nanoparticle (MSN), covalently-conjugated with two aptamers, for simultaneously targeting EpCAM and CD44, the typical surface biomarkers of colorectal CTCs. The nanomissile can specifically capture the metastasis-prone CTCs spiked in healthy human blood in a competitive-binding manner...
April 19, 2017: Nanoscale
https://www.readbyqxmd.com/read/28415395/drug-kinetics-release-from-eudragit-tenofovir-sioc-tablets
#20
A Tamayo, M A Mazo, M D Veiga, R Ruiz-Caro, F Notario-Pérez, J Rubio
A novel drug release system has been obtained in form of tablets from Eudragit® RS and tenofovir loaded on porous silicon oxycarbide glasses (SiOC). Active carbon (AC) and mesoporous silica (MCM-41) have also been used for comparative purposes. The porous silicon oxycarbide presents a bimodal mesopore size distribution that is maintained after functionalization with amino groups. We have studied the adsorption kinetics and adsorption equilibrium when the materials are loaded with tenofovir and, in all cases, pseudo-second order kinetics and Langmuir isotherm have been revealed as the most representative models describing the kinetic and thermodynamic parameters...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
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