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Neonatal sepsis

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https://www.readbyqxmd.com/read/29908311/longitudinal-study-of-neonatal-brain-tissue-volumes-in-preterm-infants-and-their-ability-to-predict-neurodevelopmental-outcome
#1
REVIEW
L Gui, S Loukas, F Lazeyras, P S Hüppi, D E Meskaldji, C Borradori Tolsa
Premature birth has been associated with poor neurodevelopmental outcomes. However, the relation between such outcomes and brain growth in the neonatal period has not yet been fully elucidated. This study investigates longitudinal brain development between birth and term-equivalent age (TEA) by quantitative imaging in a cohort of premature infants born between 26 and 36 weeks gestational age (GA), to provide insight into the relation of brain growth with later neurodevelopmental outcomes. Longitudinal T2-weighted magnetic resonance images (MRI) of 84 prematurely born infants acquired shortly after birth and TEA were automatically segmented into cortical gray matter (CGM), unmyelinated white matter (UWM), subcortical gray matter (SGM), cerebellum (CB) and cerebrospinal fluid (CSF)...
June 13, 2018: NeuroImage
https://www.readbyqxmd.com/read/29907848/cerebral-blood-flow-and-serum-neuron-specific-enolase-in-early-onset-neonatal-sepsis
#2
Mohammed S El Shimy, Nehal M El-Raggal, Rania A El-Farrash, Hebatallah A Shaaban, Hanan E Mohamed, Noha M Barakat, Ahmed S Farag, Abeer K El Zohiery, Menat Allah A Shaaban, Dina H Salama
BACKGROUND AND OBJECTIVES: Sepsis leads to systemic inflammatory response with cerebral blood flow (CBF) alteration and blood-brain barrier disruption that contribute to sepsis-associated encephalopathy (SAE). We aimed to evaluate cord blood neuron-specific enolase (cNSE) and CBF in early-onset neonatal sepsis (EONS) as predictors of SAE and to define short-term neurodevelopmental outcomes among survivors. METHODS: cNSE was measured in 200 neonates with antenatal risk factors for EONS, stratified into two groups: sepsis (n = 96) and no-sepsis (n = 104)...
May 26, 2018: Pediatric Research
https://www.readbyqxmd.com/read/29902137/vigilancia-de-la-sensibilidad-a-penicilina-en-streptococcus-agalactiae-recuperados-de-embarazadas-entre-las-35-37-semanas-de-gestaci%C3%A3-n
#3
Lucía Müller Velázquez, Fernando Bobadilla, Marina Novosak, Iliana Cortese, Margarita Laczeski
Streptococcus agalactiae (SGB) es causa de infecciones severas en menores de tres meses. Meningitis, neumonía y sepsis son los principales cuadros en estos niños. Estas infecciones se encuentran entre las más graves que puede sufrir un individuo en sus primeras doce horas de vida. El niño adquiere la infección por transmisión vertical de la madre colonizada. Para prevenir la enfermedad neonatal se recomienda penicilina como droga de elección en la profilaxis intraparto (PIP) en embarazadas colonizadas...
March 20, 2018: Revista de la Facultad de Ciencias Médicas
https://www.readbyqxmd.com/read/29898454/neonates-at-risk-of-early-onset-sepsis-which-is-the-best-approach
#4
Alberto Berardi, Caterina Spada, Maria Grazia Capretti, Matilde Ciccia, Maria Rita Pulvirenti, Martina Vezzosi, Fabrizio Sandri
No abstract text is available yet for this article.
June 13, 2018: Neonatology
https://www.readbyqxmd.com/read/29897898/mother-to-child-transmission-of-chikungunya-virus-a-systematic-review-and-meta-analysis
#5
Despina Contopoulos-Ioannidis, Shoshana Newman-Lindsay, Camille Chow, A Desiree LaBeaud
BACKGROUND: Chikungunya virus (CHIKV) is an emerging arboviral infection with a global distribution and may cause fetal and neonatal infections after maternal CHIKV-infections during gestation. METHODOLOGY: We performed a systematic review to evaluate the risk for: a) mother-to-child transmission (MTCT), b) antepartum fetal deaths (APFD), c) symptomatic neonatal disease, and d) neonatal deaths from maternal CHIKV-infections during gestation. We also recorded the neonatal clinical manifestations after such maternal infections (qualitative data synthesis)...
June 13, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29895996/maternal-and-early-perinatal-outcomes-of-triplet-pregnancy-study-of-82-triplets-from-a-single-perinatal-centre-in-south-india
#6
Priya Rajan, Srinivas Murki, Suseela Vavilala, Nirupama Surubhotla
Objectives: To study the recent trends in maternal and perinatal outcomes of triplet pregnancy from a perinatal centre in South India. Methods: All triplet pregnancies booked at Fernandez hospital, Hyderabad (a tertiary care perinatal centre in South India), or those referred between 2000 and 2014 were included in the study. The maternal, fetal and neonatal outcome and any interventions like cerclage, steroid administration were studied. Results: There were 82 triplet deliveries over the study period of 15 years (82 per 69,584 live births)...
June 2018: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29895965/association-between-early-antibiotic-exposure-and-bronchopulmonary-dysplasia-or-death
#7
Dustin D Flannery, Kevin Dysart, Alison Cook, Jay Greenspan, Zubair H Aghai, Erik A Jensen
OBJECTIVE: To characterize the independent association between antibiotic exposure in the first week of life and the risk of bronchopulmonary dysplasia (BPD) or death among very preterm infants without culture-confirmed sepsis. METHODS: Retrospective cohort study using the Optum Neonatal Database. Infants without culture-confirmed sepsis born less than 1500 g and less than 32 weeks gestation between 1/2010 and 11/2016 were included. The independent association between antibiotic therapy during the first week of life and BPD or death prior to 36 weeks postmenstrual age (PMA) was assessed by multivariable logistic regression...
June 13, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29895470/validity-of-biomarkers-in-screening-for-neonatal-sepsis-a-single-center-hospital-based-study
#8
Nagwan I Rashwan, Mohammed H Hassan, Zeinab M Mohey El-Deen, Ahmed El-Abd Ahmed
BACKGROUND: The diagnosis of neonatal sepsis still considered to be a challenge for both clinicians and the laboratory due to the non-specific clinical presentations. The present study aimed to compare and assess the diagnostic & prognostic values of C-reactive protein (CRP), high sensitivity CRP (hsCRP), presepsin, interleukin-6 (IL-6) and procalcitonin (PCT) in neonatal sepsis separately and in combination. METHODS: This hospital-based cross-sectional study has been conducted on 168 neonates recruited from the neonatal intensive care unit (NICU) of Qena University Hospitals, Upper Egypt...
May 12, 2018: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29893939/experience-of-perinatal-and-neonatal-chikungunya-virus-chikv-infection-in-a-tertiary-care-neonatal-centre-during-outbreak-in-north-india-in-2016-a-case-series
#9
Surender Kumar, Gopal Agrawal, Sanjay Wazir, Anil Kumar, Sandeep Dubey, Manish Balde, Bir Singh Yadav
Background: In 2016, there was a massive outbreak of chikungunya in North India. During the epidemic, we observed many neonatal and early infantile cases of chikungunya, with a probable perinatal transmission. Methods: This retrospective study was carried out in a tertiary care neonatal centre between August 2016 and November 2016. Chikungunya virus (CHIKV) infection was detected and confirmed by reverse transcription-polymerase chain reaction (RT-PCR) and/or serology (anti-CHIKV IgM) in mothers and infants...
June 9, 2018: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29891541/ssle-yghj-a-cell-associated-and-secreted-lipoprotein-of-neonatal-septicemic-e-coli-induces-tlr2-dependent-macrophage-activation-and-proinflammation-through-nf%C3%AE%C2%BAb-and-map-kinase-signaling
#10
Rima Tapader, Dipro Bose, Pujarini Dutta, Santasabuj Das, Amit Pal
SslE (YghJ), a cell surface associated and secreted lipoprotein was identified as a potential vaccine candidate for extraintestinal pathogenic E. coli providing nearly complete protection from sepsis in a mouse model. We earlier found that SslE from neonatal septicemic E. coli could trigger the secretion of various proinflammatory cytokines in murine macrophages, the signaling pathway of which is still obscure. In this study, we showed that SslE specifically binds to TLR2/TLR1 heterodimer and recruits downstream adaptors MyD88, TIRAP and TRAF6...
June 11, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29888655/increased-incidence-of-necrotizing-enterocolitis-associated-with-routine-administration-of-infloran%C3%A2-in-extremely-preterm-infants
#11
E Escribano, C Zozaya, R Madero, L Sánchez, J van Goudoever, J M Rodríguez, M Sáenz de Pipaon
We aimed to evaluate the isolation of strains contained in the Infloran™ probiotic preparation in blood cultures and its efficacy in reducing necrotizing enterocolitis (NEC) and late-onset sepsis (LOS) in extremely preterm infants. Routine use of probiotics was implemented in 2008. Infants born at <28 weeks gestational age were prospectively followed and compared with historical controls (HC) born between 2005 and 2008. Data on sepsis due to any of the two probiotic strains contained in Infloran and rates of LOS and NEC were analysed...
June 11, 2018: Beneficial Microbes
https://www.readbyqxmd.com/read/29888426/differential-response-to-renal-replacement-therapy-in-neonatal-onset-inborn-errors-of-metabolism
#12
Francesco Porta, Licia Peruzzi, Roberto Bonaudo, Silvia Pieretti, Marta Busso, Enrico Cocchi, Alessandra Conio, Veronica Pagliardini, Marco Spada
Severe urea cycle defects (UCDs), organic acidemias (OAs), and maple syrup urine disease (MSUD) are life-threatening disorders presenting in the first days of life. Renal replacement therapy (RRT) is an emergency option in affected newborns, mostly performed as ultima ratio. We report our 10-year experience using emergency RRT in newborns with UCDs, OAs, and MSUD. Twelve newborns (8 with UCDs, 2 with methylmalonic acidemia, and 2 with MSUD) underwent emergency RRT. The overall survival rate to RRT was 58.3%...
June 10, 2018: Nephrology
https://www.readbyqxmd.com/read/29888413/trends-in-late-onset-sepsis-in-a-neonatal-intensive-care-unit-following-implementation-of-infection-control-bundle-a-15-year-audit
#13
Pramod Pharande, Kwee B Lindrea, John Smyth, Margaret Evans, Kei Lui, Srinivas Bolisetty
AIM: Late-onset sepsis (LOS) is a frequent and important cause of morbidity and mortality in newborn infants admitted to neonatal intensive care units (NICUs). The objective of this study is to evaluate the impact of various infection control quality measures introduced as a bundle on the trends of the LOS in a NICU. METHODS: This was a prospective quality improvement study involving all neonates admitted to a NICU over a 15-year period between 2002 and 2016. The main focus areas of the bundle included collaborative team effort, hand hygiene, education, central line insertion and maintenance bundles and parenteral nutrition...
June 11, 2018: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29886794/mean-platelet-volume-in-preterm-a-predictor-of-early-onset-neonatal-sepsis
#14
Hebatallah A Shaaban, Nesma Safwat
BACKGROUND: Early onset sepsis (EOS) is potentially life-threatening problem especially in preterm. EOS diagnosis is challenging due to its nonspecific signs and laboratory tests. Mean platelet volume (MPV) has been used as predictor of many inflammatory diseases. OBJECTIVES: To assess the correlation between serial MPV measurement and EOS occurrence in preterm infants and to determine MPV effectiveness in combination with C reactive protein (CRP) to diagnose EOS and mortality prediction...
June 10, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29883983/the-relationship-of-assisted-reproductive-technology-on-perinatal-outcomes-in-triplet-gestations
#15
Jaimin S Shah, Tania Roman, Oscar A Viteri, Ziad A Haidar, Alejandra Ontiveros, Baha M Sibai
OBJECTIVE:  To assess whether assisted reproductive technology (ART) is associated with increased risk of adverse perinatal outcomes in triplet gestations compared with spontaneous conception. STUDY DESIGN:  Secondary analysis of a multicenter randomized trial for the prevention of preterm birth in multiple gestations. Triplets delivered at ≥ 24 weeks were studied. The primary outcome was the rate of composite neonatal morbidity (CNM) that included one or more of the following: bronchopulmonary dysplasia, respiratory distress syndrome, necrotizing enterocolitis, culture proven sepsis, pneumonia, retinopathy of prematurity, intraventricular hemorrhage, periventricular leukomalacia, or perinatal death...
June 8, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29881640/incidence-and-risk-factors-for-retinopathy-of-prematurity-a-retrospective-cohort-study
#16
André Moraes Freitas, Ricardo Mörschbächer, Mariana R Thorell, Ernani Luis Rhoden
Background and objectives: Advances in neonatal care promoted increased survival rates of preterm infants, with a consequent increase in the number of children affected by retinopathy of prematurity (ROP). This study estimates the incidence of ROP and evaluates potential risk factors associated. Methods: A retrospective cohort study of preterm infants born in a tertiary neonatal intensive care unit was conducted from March 2005 to August 2015. Six hundred and thirty-nine newborns were included based on the following criteria: infants born with less than 32 weeks' gestation or birth weight below 1500 g; or neonates born with 32-37 weeks' gestation or birth weight above 1500 g and any of the following associated: multiple gestation, respiratory distress syndrome, sepsis, blood transfusions or intraventricular hemorrhage...
2018: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/29878061/nutrient-enrichment-of-human-milk-with-human-and-bovine-milk-based-fortifiers-for-infants-born-weighing-1250-g-a-randomized-clinical-trial
#17
Deborah L O'Connor, Alex Kiss, Christopher Tomlinson, Nicole Bando, Ann Bayliss, Douglas M Campbell, Alan Daneman, Jane Francis, Kirsten Kotsopoulos, Prakesh S Shah, Simone Vaz, Brock Williams, Sharon Unger
Background: Human milk-based fortifiers (HMBFs) are being adopted in neonatal care to enrich the nutrients in human milk for very low birth weight (VLBW) infants despite being costly and there being limited efficacy data. No randomized clinical trial has evaluated the use of HMBF compared with bovine milk-based fortifiers (BMBFs) in the absence of formula feeding. Objective: To determine if HMBF compared with BMBF for routine nutrient enrichment of human milk improves feeding tolerance, reduces morbidity, reduces fecal calprotectin (a measure of gut inflammation), and supports the growth of infants <1250 g...
June 6, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29875143/the-microbiome-and-metabolome-of-preterm-infant-stool-are-personalized-and-not-driven-by-health-outcomes-including-necrotizing-enterocolitis-and-late-onset-sepsis
#18
Stephen Wandro, Stephanie Osborne, Claudia Enriquez, Christine Bixby, Antonio Arrieta, Katrine Whiteson
The assembly and development of the gut microbiome in infants have important consequences for immediate and long-term health. Preterm infants represent an abnormal case for bacterial colonization because of early exposure to bacteria and frequent use of antibiotics. To better understand the assembly of the gut microbiota in preterm infants, fecal samples were collected from 32 very low birth weight preterm infants over the first 6 weeks of life. Infant health outcomes included health, late-onset sepsis, and necrotizing enterocolitis (NEC)...
June 27, 2018: MSphere
https://www.readbyqxmd.com/read/29871901/increased-detection-of-human-parechovirus-infection-in-infants-in-england-during-2016-epidemiology-and-clinical-characteristics
#19
Laura Ferreras Antolín, Seilesh Kadambari, Serena Braccio, Julian Wei-Tze Tang, Jacqueline Xerry, David James Allen, Shamez N Ladhani
BACKGROUND: Human parechovirus (HPeV), like enteroviruses, usually causes mild self-limiting respiratory and gastrointestinal symptoms. In infants, HPeV can occasionally cause serious illnesses, including sepsis-like syndrome and encephalitis. In summer 2016, Public Health England (PHE) received increasing reports of severe HPeV infections nationally. We, therefore, reviewed all infants with confirmed HPeV across England during 2016. METHODS: HPeV cases in infants aged <12 months reported to PHE during 2016 were followed up using a clinical questionnaire...
June 5, 2018: Archives of Disease in Childhood
https://www.readbyqxmd.com/read/29862053/appropriate-and-timely-antibiotic-administration-for-neonatal-sepsis-in-mesoam%C3%A3-rica
#20
Herbert C Duber, Emily A Hartford, Alexandra M Schaefer, Casey K Johanns, Danny V Colombara, Emma Iriarte, Erin B Palmisano, Diego Rios-Zertuche, Paola Zuniga-Brenes, Bernardo Hernández-Prado, Ali H Mokdad
Neonatal sepsis is a leading cause of mortality among children under-5 in Latin America. The Salud Mesoamérica Initiative (SMI), a multicountry results-based aid programme, was designed to improve maternal, newborn and child health in impoverished communities in Mesoamérica. This study examines the delivery of timely and appropriate antibiotics for neonatal sepsis among facilities participating in the SMI project. A multifaceted health facility survey was implemented at SMI inception and approximately 18 months later as a follow-up...
2018: BMJ Global Health
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