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https://www.readbyqxmd.com/read/30007038/prognostic-value-of-h3s10-phosphorylation-and-h4k12-acetylation-in-oral-squamous-cell-carcinoma
#1
Esther Campos-Fernández, Flavia Sayuri Matsuo, Marília Ferreira Andrade, João Paulo Silva Servato, Adriano Mota Loyola, Sérgio Vitorino Cardoso, Sindeval José Siva, Alberto da Silva Moraes, Paulo Rogério de Faria
AIMS: Studies about epigenetics in oral squamous cell carcinoma (OSCC) are rare. Histone modifications comprise epigenetic mechanisms that perform a key role in gene transcription and may regulate tumour development. Thus, we asked whether the following post-translational histone modifications, H3S10 phosphorylation (H3S10ph) and H4K12 acetylation (H4K12ac) had prognostic value for OSCC patients. METHODS AND RESULTS: Paraffin-embedded tissue samples of 90 patients diagnosed with OSCC were raised and submitted to immunohistochemical staining with antibodies against H3S10ph and H4K12ac...
July 14, 2018: Histopathology
https://www.readbyqxmd.com/read/30006927/gata3-as-a-master-regulator-and-therapeutic-target-in-ovarian-high-grade-serous-carcinoma-stem-cells
#2
Hsiang-Ju Chen, Rui-Lan Huang, Phui-Ly Liew, Po-Hsuan Su, Lin-Yu Chen, Yu-Chun Weng, Cheng-Chang Chang, Yu-Chi Wang, Michael Wing-Yan Chan, Hung-Cheng Lai
Ovarian high-grade serous carcinoma (HGSC) is the most lethal gynecological malignancy. Prevailing evidences suggest that drug resistance and recurrence of ovarian HGSC are caused by the presence of cancer stem cells. Therefore, targeting cancer stems is appealing, however, all attempts to date, have failed. To circumvent this limit, we analyzed differential transcriptomes at early differentiation of ovarian HGSC stem cells and identified the developmental transcription factor GATA3 as highly expressed in stem, compared to progenitor cells...
July 14, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30006924/triptolide-inhibits-wnt-signaling-in-nsclc-through-upregulation-of-multiple-wnt-inhibitory-factors-via-epigenetic-modifications-to-histone-h3
#3
Isaac Nardi, Theresa Reno, Xinwei Yun, Terra Sztain, Jami Wang, Huifang Dai, Li Zheng, Jae Kim, Dan Raz
In the last decade, it has become clear that epigenetic changes act together with genetic mutations to promote virtually every stage of tumorigenesis and cancer progression. This knowledge has triggered searches for "epigenetic drugs" that can be developed into new cancer therapies. Here we report that triptolide reduced lung cancer incidence from 70% to 10% in a Fen1 E160D transgenic mouse model and effectively inhibited cancer growth and metastasis in A549 and H460 mouse xenografts. We found that triptolide induced lung cancer cell apoptosis that was associated with global epigenetic changes to histone 3 (H3)...
July 14, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30006761/neonatal-dexamethasone-treatment-suppresses-hippocampal-estrogen-receptor-%C3%AE-expression-in-adolescent-female-rats
#4
Hui-Fang Chiu, Michael W Y Chan, Chiung-Yin Cheng, Jian-Liang Chou, Jora Meng-Ju Lin, Yi-Ling Yang, Kwok-Tung Lu
Previous studies showed that neonatal dexamethasone treatment (NDT) transiently impaired hippocampal function in male rats. Hippocampal estrogen receptors (ERs) participate in avoidance learning. As previous studies focused on males only, this study was aimed to investigate the NDT effects on the hippocampal function of female rats. Newborn Wistar female rats were subjected to a tapering dose of dexamethasone (0.5 mg, 0.3 mg, and 0.1 mg/kg, subcutaneously) from postnatal days 1 to 3 and were subjected to experiments at the age of 6 weeks (adolescence)...
July 13, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/30006681/molecular-biology-as-a-tool-for-the-treatment-of-cancer
#5
REVIEW
Carla de Castro Sant' Anna, Alberto Gomes Ferreira Junior, Paulo Soares, Fabricio Tuji, Eric Paschoal, Luiz Cláudio Chaves, Rommel Rodriguez Burbano
Cancer is a genetic disease characterized by uncontrolled cell growth and metastasis. Cancer can have a number of causes, such the activation of oncogenes, the inactivation of tumor-suppressing genes, mutagenesis provoked by external factors, and epigenetic modifications. The development of diagnostic tools and treatments using a molecular biological approach permits the use of sensitive, low-cost, noninvasive tests for cancer patients. Biomarkers can be used to provide rapid, personalized oncology, in particular the molecular diagnosis of chronic myeloid leukemia, and gastric, colon, and breast cancers...
July 13, 2018: Clinical and Experimental Medicine
https://www.readbyqxmd.com/read/30006572/atp-synthase-f-1-subunits-recruited-to-centromeres-by-cenp-a-are-required-for-male-meiosis
#6
Caitríona M Collins, Beatrice Malacrida, Colin Burke, Patrick A Kiely, Elaine M Dunleavy
The histone H3 variant CENP-A epigenetically defines the centromere and is critical for chromosome segregation. Here we report an interaction between CENP-A and subunits of the mitochondrial ATP synthase complex in the germline of male Drosophila. Furthermore, we report that knockdown of CENP-A, as well as subunits ATPsyn-α, -βlike (a testis-specific paralogue of ATPsyn-β) and -γ disrupts sister centromere cohesion in meiotic prophase I. We find that this disruption is likely independent of reduced ATP levels...
July 13, 2018: Nature Communications
https://www.readbyqxmd.com/read/30006558/neonatal-anesthesia-exposure-impacts-brain-micrornas-and-their-associated-neurodevelopmental-processes
#7
Daisy Lin, Jinyang Liu, Zihua Hu, James E Cottrell, Ira S Kass
MicroRNAs (miRNAs), when subjected to environmental stimuli, can exhibit differential expression. As critical regulators of gene expression, differential miRNA expression has been implicated in numerous disorders of the nervous system. In this study, we focused on the effect of a general anesthetic, as an environmental stimulus, on miRNA expression of the developing brain. General anesthetics have potential long-lasting neurotoxic effects on the developing brain, resulting in behavioral changes in adulthood...
July 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30006526/aberrant-imprinting-may-underlie-evolution-of-parthenogenesis
#8
Olga Kirioukhova, Jubin N Shah, Danaé S Larsen, Muhammad Tayyab, Nora E Mueller, Geetha Govind, Célia Baroux, Michael Federer, Jacqueline Gheyselinck, Philippa J Barrell, Hong Ma, Stefanie Sprunck, Bruno Huettel, Helen Wallace, Ueli Grossniklaus, Amal J Johnston
Genomic imprinting confers parent-of-origin-specific gene expression, thus non-equivalent and complementary function of parental genomes. As a consequence, genomic imprinting poses an epigenetic barrier to parthenogenesis in sexual organisms. We report aberrant imprinting in Boechera, a genus in which apomicts evolved from sexuals multiple times. Maternal activation of a MADS-box gene, a homolog of which is imprinted and paternally expressed in the sexual relative Arabidopsis, is accompanied by locus-specific DNA methylation changes in apomicts where parental imprinting seems to be relaxed...
July 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30006485/the-oncometabolite-d-2-hydroxyglutarate-is-an-intercellular-mediator-in-idh-mutant-gliomas-that-inhibits-both-complement-and-t-cells
#9
Lingjun Zhang, Mia Sorensen, Bjarne W Kristensen, Guido Reifenberger, Thomas M McIntyre, Feng Lin
PURPOSE: Somatic mutations in the isocitrate dehydrogenase (IDH)-1 and -2 genes are remarkably penetrant in diffuse gliomas. These highly effective gain-of-function mutations enable mutant IDH to efficiently metabolize isocitrate to D-2-hydroxyglutarate (D 2-HG) that accumulates to high concentrations within the tumor microenvironment. D 2-HG is an intracellular effector that promotes tumor growth through widespread epigenetic changes in IDH mutant tumor cells, but its potential role as an intercellular immune regulator remains understudied...
July 13, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/30006306/aflatoxin-b-1-induced-multiple-epigenetic-modulators-in-human-epithelial-cell-lines
#10
Priyanka Soni, Md Sajid Ghufran, Santosh R Kanade
The compulsive and insidious secondary metabolite aflatoxin B1 , produced by the opportunistic fungi Aspergillus flavus, upholds a distinguished place in midst of the toxicants causing fatal hazards to humans. Aflatoxins alter the function of host cells by inducing multiple effects through genetic and non-genetic pathways. Epigenetic mechanisms drag major attention towards finding novel and new mechanisms involved in this process. Our present work intends to study the functional expression profile of multiple epigenetic regulators...
July 10, 2018: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/30006025/the-function-of-long-non-coding-rna-mt1jp-in-the-development-and-progression-of-gastric-cancer
#11
Zhongchuan Lv, Yong Zhang, Xiang Yu, Yang Lin, Yinlin Ge
Gastric cancer is one of the most common malignant tumors with the third mortality rate of cancer in world. A larger number of researches showed that genetic factors played an important role in the development of gastric cancer. More and more evidences have indicated that lncRNAs can regulate the gene expression through the transcription, post transcription and epigenetic levels including cancer invasion and metastasis, cell differentiation and apoptosis. However, the mechanisms of lncRNAs in the pathogenesis of gastric cancer remaining unclear...
July 7, 2018: Pathology, Research and Practice
https://www.readbyqxmd.com/read/30005894/histone-acetylation-and-methylation-marks-in-chromatin-of-panstrongylus-megistus-hemiptera-reduviidae
#12
Elenice M Alvarenga, Carlos H L Imperador, Vanessa B Bardella, Vera L C C Rodrigues, Mateus Mondin, Diogo C Cabral-de-Mello, Alberto S Moraes, Maria Luiza S Mello
Panstrongylus megistus, a potential vector of Chagas disease, currently occupies a wider geographic distribution in Brazil than Triatoma infestans, another member of the hemipteran Reduviidae family and a vector of the same disease. A small heterochromatic body (chromocenter) formed by the Y chromosome is evident in the somatic cells of P. megistus, differing in size and chromosome type contribution from the well-studied chromocenters present in T. infestans. While the overall distribution of histone epigenetic marks differ when comparing the heterochromatin and euchromatin territories in T...
July 10, 2018: Acta Histochemica
https://www.readbyqxmd.com/read/30005706/loss-of-maternal-eed-results-in-postnatal-overgrowth
#13
Lexie Prokopuk, Jessica M Stringer, Craig R White, Rolf H A M Vossen, Stefan J White, Ana S A Cohen, William T Gibson, Patrick S Western
BACKGROUND: Investigating how epigenetic information is transmitted through the mammalian germline is the key to understanding how this information impacts on health and disease susceptibility in offspring. EED is essential for regulating the repressive histone modification, histone 3 lysine 27 tri-methylation (H3K27me3) at many developmental genes. RESULTS: In this study, we used oocyte-specific Zp3-Cre recombinase (Zp3Cre) to delete Eed specifically in mouse growing oocytes, permitting the study of EED function in oocytes and the impact of depleting EED in oocytes on outcomes in offspring...
July 13, 2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/30005692/vitamin-c-increases-5-hydroxymethylcytosine-level-and-inhibits-the-growth-of-bladder-cancer
#14
Ding Peng, Guangzhe Ge, Yanqing Gong, Yonghao Zhan, Shiming He, Bao Guan, Yifan Li, Ziying Xu, Han Hao, Zhisong He, Gengyan Xiong, Cuijian Zhang, Yue Shi, Yuanyuan Zhou, Weimin Ci, Xuesong Li, Liqun Zhou
BACKGROUND: 5-Hydroxymethylcytosine (5hmC) is converted from 5-methylcytosine (5mC) by a group of enzymes termed ten-eleven translocation (TET) family dioxygenases. The loss of 5hmC has been identified as a hallmark of most types of cancer and is related to tumorigenesis and progression. However, the role of 5hmC in bladder cancer is seldom investigated. Vitamin C was recently reported to induce the generation of 5hmC by acting as a cofactor for TET dioxygenases. In this study, we explored the role of 5hmC in bladder cancer and the therapeutic efficacy of vitamin C in increasing the 5hmC pattern...
July 13, 2018: Clinical Epigenetics
https://www.readbyqxmd.com/read/30005373/impact-of-antipsychotic-treatment-on-methylation-status-of-interleukin-6-il-6-gene-in-schizophrenia
#15
Deepthi Venugopal, Venkataram Shivakumar, Manjula Subbanna, Sunil V Kalmady, Anekal C Amaresha, Sri Mahavir Agarwal, Janardhanan C Narayanaswamy, Moinak Banerjee, Monojit Debnath, Ganesan Venkatasubramanian
Immunopathogenesis of schizophrenia has emerged as one of the predominant research paradigms in recent times. Based on the altered serum levels as well as gene expression, IL-6 has been considered as a peripheral biomarker of schizophrenia. However, the precise mechanism underlying the altered expression of IL6 in schizophrenia is inadequately known. Given the profound influence of environmental factors on schizophrenia risk, it is important to understand the effect of epigenetic changes on schizophrenia risk...
July 7, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/30005188/prenatal-exposure-to-persistent-organic-pollutants-and-methylation-of-line-1-and-imprinted-genes-in-placenta-a-check-cohort-study
#16
Sujin Kim, Yoon Hee Cho, Inae Lee, Wonji Kim, Sungho Won, Ja-Lok Ku, Hyo-Bang Moon, Jeongim Park, Sungkyoon Kim, Gyuyeon Choi, Kyungho Choi
Prenatal exposure to persistent organic pollutants (POPs) has been linked to numerous adverse birth outcomes among newborn infants in many epidemiological studies. Although epigenetic modifications have been suggested as possible explanations for those associations, studies have rarely reported a relationship between POP exposure during pregnancy and DNA methylation in the placenta. In the present study, we investigated the association between prenatal exposure to several POPs, including organochlorine pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), and polychlorinated biphenyls (PCBs), and methylation levels of long interspersed element 1 (LINE-1), as well as imprinted genes in placental DNAs among Korean mother-child pairs (N = 109)...
July 10, 2018: Environment International
https://www.readbyqxmd.com/read/30004838/persistent-pulmonary-hypertension-alters-epigenetic-characteristics-of-endothelial-nitric-oxide-synthase-gene-in-a-fetal-lamb-model
#17
Xingrao Ke, Hollis Johnson, Xigang Jing, Teresa Michalkiewicz, Yi-Wen Huang, Robert H Lane, Girija G Konduri
Decreased expression of endothelial nitric oxide synthase (eNOS), a key mediator of perinatal transition, characterizes persistent pulmonary hypertension of the newborn (PPHN) in neonates and a fetal lamb model; the mechanisms are unclear. We investigated whether increased DNA CpG methylation at the eNOS promoter in estrogen response elements (EREs) and altered histone code together contribute to decreased eNOS expression in PPHN. We isolated pulmonary artery endothelial cells (PAEC) from fetal lambs with PPHN induced by prenatal ductus arteriosus constriction from 128-136 days gestation or gestation matched twin controls...
July 13, 2018: Physiological Genomics
https://www.readbyqxmd.com/read/30004397/conditions-and-dynamics-that-impact-maternal-health-literacy-among-high-risk-prenatal-interconceptional-women
#18
Suzanne D Thomas, Sandra C Mobley, Jodi L Hudgins, Donald E Sutherland, Sandra B Inglett, Brittany L Ange
The purpose of the study was to describe conditions and dynamics in the lives of high-risk, low-income, Southern United States prenatal-interconceptional women ( n = 37) in a home visiting program that promoted maternal health literacy progression. In the Life Course Health Development (LCHD) Model, conditions were risk and protective factors that impacted health. Dynamics drove the complex, epigenetic relationships between risk and protective factors. Maternal health literacy promotion helped participants address conditions and dynamics to create positive life changes...
July 2, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/30003817/the-epigenetic-modification-during-the-induction-of-foxp3-with-sodium-butyrate
#19
Tengli Cao, Xiuxiu Zhang, Dingding Chen, Peiyan Zhang, Qing Li, Abbas Muhammad
CONTEXT: CD4 + CD25+ regulatory T (Treg) lymphocytes are critical for immune homeostasis. Foxp3 (Forkhead Box protein P3) is always considered as a marker of function and identities determination of Treg cells because of special occurring in Treg cell. People who lack Treg cells or have a low expression of Foxp3 gene will suffer fatal autoimmunity. Scientists are trying to use Treg cells as a treatment for autoimmune disease, such as systemic lupus erythematosus. OBJECTIVE: Our objective was to induce Foxp3 + CD4+ T cells from naïve CD4 + T cells isolated from C57 mice spleen in vitro using stimuli that include the short chain fatty acid sodium butyrate...
July 13, 2018: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/30003608/the-impact-of-transposable-elements-in-adaptive-evolution
#20
Lukas Schrader, Jürgen Schmitz
The growing knowledge about the influence of transposable elements (TEs) on (1) long-term genome and transcriptome evolution, (2) genomic, transcriptomic and epigenetic variation within populations, and (3) patterns of somatic genetic differences in individuals continues to spur the interest of evolutionary biologists in the role of TEs in adaptive evolution. As TEs can trigger a broad range of molecular variation in a population with potentially severe fitness and phenotypic consequences for individuals, different mechanisms evolved to keep TE activity in check, allowing for a dynamic interplay between the host, its TEs and the environment in evolution...
July 13, 2018: Molecular Ecology
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