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Katrien Benhalima, Paul Van Crombrugge, Carolien Moyson, Johan Verhaeghe, Sofie Vandeginste, Hilde Verlaenen, Chris Vercammen, Toon Maes, Els Dufraimont, Christophe De Block, Yves Jacquemyn, Farah Mekahli, Katrien De Clippel, Annick Van Den Bruel, Anne Loccufier, Annouschka Laenen, Caro Minschart, Roland Devlieger, Chantal Mathieu
This study determines if a modified two-step screening strategy with a glucose challenge test (GCT) ≥ 7.2 mmol/L and clinical risk factors improves the diagnostic accuracy for gestational diabetes mellitus (GDM), based on 2013 WHO criteria, while limiting the number of oral glucose tolerance tests (OGTT). This was a prospective multicentric cohort study with 1811 participants receiving both GCT and 75 g OGTT in pregnancy. Participants and health care providers were blinded for GCT. Characteristics were analyzed across four glucose tolerance groups: abnormal (≥7...
October 13, 2018: Journal of Clinical Medicine
Maria Alexandri, Roland Schneider, Joachim Venus
Lactic acid (LA) was produced on a pilot scale using a defined medium with glucose, acid whey, sugar bread and crust bread. The fermentation broths were then subjected to micro- and nanofiltration. Microfiltration efficiently separated the microbial cells. The highest average permeate flow flux was achieved for the defined medium (263.3 L/m²/h) and the lowest for the crust bread-based medium (103.8 L/m²/h). No LA losses were observed during microfiltration of the acid whey, whilst the highest retention of LA was 21...
October 12, 2018: Membranes
Baljinder S Dhinsa, Ahmed Latif, Roland Walker, Ali Abbasian, Diane Back, Sam Singh
BACKGROUND: There remains a lack of recognition of these fractures, which leads to a delay in diagnosis and appropriate management. METHODS: A comprehensive literature search was performed. Following inclusion and exclusion criteria, 23 studies were available for analysis. RESULTS: Delay in diagnosis is common and has a negative impact on outcome. If an APC fracture is suspected; anteroposterior, lateral and oblique plain radiographs should be requested...
February 21, 2018: Foot and Ankle Surgery: Official Journal of the European Society of Foot and Ankle Surgeons
Juliana E Hidalgo-Lόpez, Rashmi Kanagal-Shamanna, Andrés E Quesada, Zimu Gong, Wei Wang, Shimin Hu, L Jeffrey Medeiros, Roland L Bassett, Elizabeth d'Orcy, C Cameron Yin, Jorge Cortes, Elias J Jabbour, Hagop M Kantarjian, Carlos E Bueso-Ramos
BACKGROUND: The diagnosis of chronic myeloid leukemia (CML) is based on characteristic clinical and laboratory findings and the presence of BCR/ABL1 in the blood and/or bone marrow (BM). The utility of BM core biopsy in the workup of patients with CML has been questioned. METHODS: The potential added value of BM biopsy versus aspiration in the workup of a single-institution series of 508 patients with CML at their initial presentation was systematically assessed...
October 15, 2018: Cancer
M Jamoulle, M Roland, J M Bae, B Heleno, G Visentin, G Gusso, M Godycki-Cwirko, M Pizzanelli, P Ouvrard, R La Vallev, F Gomes, D Widmer, J Bernstein, M Marino, H Lima Wagner, I Rossi
The concept of quaternary prevention, resulting from a reflection on the doctor-patient relationship, is presented as a renewal of the ageold ethical requirement: first, a doctor must not harm; second, the doctor must control himself/herself. The origin of the concept, its endorsement by the World Organization of Family Doctors (WONCA) and the European Union of General Practitioners (UEMO), its dissemination, and the debates to which it has given rise, are presented by a panel of authors from 12 countries and 3 continents...
2018: Revue Médicale de Bruxelles
Fouad Aoun, Simone Albisinni, Roland van Velthoven
PURPOSE OF REVIEW: We summarize the evidence on accurate target definition, precise imaging, and guiding systems that are a necessary ground to targeted focal therapy. RECENT FINDINGS: Accurate target detection is based on the ability of imaging to locate and characterize precisely the tumor burden and differentiation inside the prostate. There is a clear correlation with the multiparametric MRI (mpMRI) images and the morphologic attributes of the tumor. Limitations stem from the heterogeneity and the multifocality of prostate cancer...
October 12, 2018: Current Opinion in Urology
Bastian Schirmer, Luisa Bringmann, Roland Seifert, Detlef Neumann
Our previous in vitro studies revealed that histamine via histamine the H4 -receptors (H4 R), as compared to other stimuli, such as eotaxin or formylpeptides, rather partially activates eosinophilic granulocytes (eosinophils). In order to evaluate the H4 R-mediated activation of eosinophils in vivo , we employed dextran sodium sulfate (DSS)-induced colitis in mice, closely resembling human ulcerative colitis (UC), which is largely characterized by a local eosinophilic infiltration of the colon. IL-5-deficient BALB/c mice served as a model with reduced endogenous numbers of eosinophils, in which wild-type (H4 R+/+ ) or H4 R-deficient (H4 R-/- ) eosinophils were adoptively transferred during the course of DSS-induced colitis...
2018: Frontiers in Immunology
Roland Wirth, Gyula Kádár, Balázs Kakuk, Gergely Maróti, Zoltán Bagi, Árpád Szilágyi, Gábor Rákhely, József Horváth, Kornél L Kovács
The cow rumen harbors a great variety of diverse microbes, which form a complex, organized community. Understanding the behavior of this multifarious network is crucial in improving ruminant nutrient use efficiency. The aim of this study was to expand our knowledge by examining 10 Holstein dairy cow rumen fluid fraction whole metagenome and transcriptome datasets. DNA and mRNA sequence data, generated by Ion Torrent, was subjected to quality control and filtering before analysis for core elements. The taxonomic core microbiome consisted of 48 genera belonging to Bacteria (47) and Archaea (1)...
2018: Frontiers in Microbiology
Franca Wagner, Lorenz Grunder, Arsany Hakim, Nicole Kamber, Michael P Horn, Julia Muellner, Robert Hoepner, Roland Wiest, Imke Metz, Andrew Chan, Anke Salmen
Objective: Differential diagnosis of neuromyelitis optica spectrum disorders (NMOSD) and multiple sclerosis (MS) or mimics can be challenging, especially in patients with atypical presentations and negative serostatus for aquaporin-4 antibodies (AQP4-Ab). This brief research report describes magnetic resonance imaging (MRI) findings focusing on quantitative apparent diffusion coefficient (ADC) histogram analysis as a potential tool to differentiate NMOSD from MS. Methods: Longitudinal MRI data obtained during routine clinical examinations were retrospectively analyzed in a patient with histologically determined cerebral NMOSD, a patient with an acute tumefactive MS lesion, and a patient with ischemic stroke...
2018: Frontiers in Neurology
Jaya Kumar, Amro Solaiman, Pasuk Mahakkanukrauh, Rashidi Mohamed, Srijit Das
In the last several decades, sleep-related epilepsy has drawn considerable attention among epileptologists and neuroscientists in the interest of new paradigms of the disease etiology, pathogenesis and management. Sleep-related epilepsy is nocturnal seizures that manifest solely during the sleep state. Sleep comprises two distinct stages i.e., non-rapid eye movement (NREM) and rapid eye movement (REM) that alternate every 90 min with NREM preceding REM. Current findings indicate that the sleep-related epilepsy manifests predominantly during the synchronized stages of sleep; NREM over REM stage...
2018: Frontiers in Pharmacology
Adam P Holt, C M Roland
The local segmental and secondary dynamics of tetramethylene oxide oligomer grafted to silica nanoparticles (NPs) were investigated as a function of grafting density and molecular weight. Grafting slows the segmental (α) dynamics, but gives rise to faster secondary (β) motions. Interestingly, the magnitude of these effects decreases with the extent of grafting (i.e., surface coverage), as well as with oligomer molecular weight. The disparity in dynamical effects reflects the decoupling of the segmental and more local β dynamics, the former is associated with stronger dynamic correlations that extend over a greater spatial range...
October 15, 2018: Soft Matter
Roland von Känel, Nadja Heimgartner, Monika Stutz, Claudia Zuccarella-Hackl, Alexander Hänsel, Ulrike Ehlert, Petra H Wirtz
BACKGROUND: Stress-induced prothrombotic changes are mediated by the sympathetic nervous system and critically involved in mental triggering of acute coronary syndromes, but the underlying psychobiology is not fully understood. We tested the hypothesis that a norepinephrine (NE) infusion to mimic effects of stress-induced NE release on blood coagulation elicits prothrombotic changes and examined to what extent these would be mediated by an alpha-adrenergic mechanism. METHODS AND RESULTS: In a single-blind placebo-controlled within-subjects design, 24 middle-aged, non-smoking, non-obese and normotensive men participated in three experimental trials with an interval between one and two weeks...
September 14, 2018: Psychoneuroendocrinology
Jiacheng Shen, Roland Treu, Junye Wang, Fiona Nicholson, Anne Bhogal, Rachel Thorman
Organic fertilizers, such as digestates and manure, are increasingly applied in agricultural systems because of the benefits they provide in terms of plant nutrients and soil quality. However, there are few investigations of N2 O emissions following digestate application to agricultural soils using process-based models. In this study, we modified the UK-DNDC model to include digestate applications to soils by adding digestate properties to the model and considering the effect of organic fertilizer pH. Using the modified model, N2 O emissions were simulated from two organic fertilizers (digested food waste and livestock slurry) applied to three farms in the United Kingdom: one growing winter wheat at Wensum (WE) and two grasslands at Pwllpeiran (PW) and North Wyke (NW)...
September 3, 2018: Environmental Pollution
Emily Z Keung, Yi-Ju Chiang, Janice N Cormier, Keila E Torres, Kelly K Hunt, Barry W Feig, Christina L Roland
BACKGROUND: Retroperitoneal sarcomas (RPS) are rare tumors for which complete surgical resection remains the mainstay of treatment. The objective of the current study was to determine the impact of hospital case volume on outcomes in patients with RPS. METHODS: A total of 6950 patients with primary RPS who underwent surgical resection were identified from the National Cancer Data Base (1998-2011). Treating hospitals were classified by annual case volume; low-volume hospitals (LVHs) and high-volume hospitals (HVHs) were defined as those with ≤10 cases per year and >10 cases per year, respectively...
October 14, 2018: Cancer
Katharina A Schwarz, Sebastian Burger, David Dignath, Wilfried Kunde, Roland Pfister
The sense of agency is a pervasive phenomenon that accompanies conscious acting and extends to the consequences of one's actions in the environment. Subjective feelings of agency are typically explained in terms of predictive processes, based on internal forward models inherent to the sensorimotor system, and postdictive processes, i.e., explicit, retrospective judgments by the agent. Only recently, research has begun to elucidate the link between sense of agency and more basic processes of human action control...
October 10, 2018: Consciousness and Cognition
Marius Herzog, Lei Li, Hans-Joachim Galla, Roland Winter
The role of hyaluronic acid (HA) in supporting low friction and low abrasion during movement in synovial joints is still not fully understood. In this study, we set out to investigate the interaction between HA and representative lipid model membranes, bilayers as well as monolayers, in detail using a variety of calorimetric, spectroscopic, scattering and microscopic techniques, to explore their role in lubrication of articular cartridge. We also cover a wide range of pressures to mimic pressures occurring upon joint movement, aiming at elucidating a possible mechanism for the low friction forces in synovial joints...
October 3, 2018: Colloids and Surfaces. B, Biointerfaces
Megan Othus, Elihu H Estey, Guillermo Garcia-Manero, Brent L Wood, Derek L Stirewalt, John E Godwin, James K Weick, Jeanne E Anderson, Frederick R Appelbaum, Harry P Erba, Roland B Walter
No abstract text is available yet for this article.
October 12, 2018: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
Viki Bockstal, Machteld M Tiemessen, Rogier Achterberg, Carlo Van Wordragen, Ad M Knaapen, Jan Serroyen, Wilfred E Marissen, Hanneke Schuitemaker, Roland Zahn
BACKGROUND: The World Health Organization recommends the development of affordable next-generation inactivated poliovirus vaccines (IPV) using attenuated poliovirus Sabin strains. Previously, we introduced a novel PER.C6® cell culture platform, which allows for high yield production of an affordable trivalent Sabin IPV vaccine. METHODS: Immunogenicity and safety of this novel PER.C6®-based Sabin-IPV (sIPV) was assessed in rats and non-human primates (NHPs). NHPs received one of four different dose dilutions vaccine according to current human schedule (three prime-immunizations and one boost immunization)...
October 9, 2018: Vaccine
Katrien Benhalima, Caro Minschart, Dries Ceulemans, Annick Bogaerts, Bart Van Der Schueren, Chantal Mathieu, Roland Devlieger
Gestational diabetes mellitus (GDM) is a frequent medical complication during pregnancy. This is partly due to the increasing prevalence of obesity in women of childbearing age. Since bariatric surgery is currently the most successful way to achieve maintained weight loss, increasing numbers of obese women of childbearing age receive bariatric surgery. Bariatric surgery performed before pregnancy significantly reduces the risk to develop GDM but the risk is generally still higher compared to normal weight pregnant women...
October 11, 2018: Nutrients
Amina Brahimi, Roland Libois, Arnaud Henrard, JÖrg Freyhof
Two new species of Luciobarbus are described from the Mediterranean Sea basin in Morocco and Algeria. Their monophyly and phylogenetic placement are resolved by molecular analyses using two mitochondrial markers (cyt b and D-loop). Luciobarbus lanigarensis, new species, from the Tafna River drainage in Algeria and Morocco, is distinguished by having orange fins, a great predorsal length (52-59% SL) and a very long pectoral fin (79-90% HL). Luciobarbus numidiensis, new species, from the El-Kébir River drainage in Algeria, is distinguished by having a golden pectoral-fin margin, 43-47+1-3 lateral line scales and a very long anal-fin (19-23%)...
June 13, 2018: Zootaxa
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