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JOURNAL ARTICLE
Pawel Szulc, Danielle E Whittier, Steven K Boyd, Roland Chapurlat
Older men with high bone turnover have faster bone loss. We assessed the link between the baseline levels of bone turnover markers (BTMs) and the prospectively assessed bone microarchitecture decline in men. In 825 men aged 60-87 yr, we measured the serum osteocalcin (OC), bone alkaline phosphatase (BAP), N-terminal propeptide of type I procollagen (PINP), and C-terminal telopeptide of type I collagen (CTX-I), and urinary total deoxypyridinoline (tDPD). Bone microarchitecture and strength (distal radius and distal tibia) were estimated by high-resolution pQCT (XtremeCT, Scanco Medical) at baseline and then after 4 and 8 yr...
March 4, 2024: Journal of Bone and Mineral Research
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JOURNAL ARTICLE
Stefanie Bruschke, Roland Zeh, Uwe Baumann, Silke Helbig, Timo Stöver
BACKGROUND: The Association of the Scientific Medical Societies in Germany (AWMF) clinical practice guideline on cochlear implant (CI) treatment, which was updated in 2020, defined the entire process of CI care for the first time. In the present study, the feasibility and results of very early rehabilitation were examined. MATERIALS AND METHODS: The intervention group (IG) comprised 54 patients in whom rehabilitation was initiated within 14 (maximally 28) days after implantation...
April 17, 2024: HNO
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JOURNAL ARTICLE
Darryl Kato, Regina Wai-Yan Choy, Eda Canales, Ryan A Dick, April D Lake, Nathan D Shapiro, Elbert Chin, Jiayao Li, Jennifer R Zhang, Qiaoyin Wu, Roland D Saito, Sammy Metobo, Evangelos Aktoudianakis, Scott D Schroeder, Zheng-Yu Yang, Dylan M Glatt, Scott Balsitis, Lindsay Gamelin, Mei Yu, Guofeng Cheng, William E Delaney, John O Link
Chronic hepatitis B (CHB) virus infection afflicts hundreds of millions of people and causes nearly one million deaths annually. The high levels of circulating viral surface antigen (HBsAg) that characterize CHB may lead to T-cell exhaustion, resulting in an impaired antiviral immune response in the host. Agents that suppress HBsAg could help invigorate immunity toward infected hepatocytes and facilitate a functional cure. A series of dihydropyridoisoquinolizinone (DHQ) inhibitors of human poly(A) polymerases PAPD5/7 were reported to suppress HBsAg in vitro...
April 11, 2024: ACS Medicinal Chemistry Letters
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JOURNAL ARTICLE
Ryan J Keneally, Eric R Heinz, Edward M Jaffe, Bhiken I Niak, Andrew B Canonico, Laura M Roland, Jonathan H Chow, Michael A Mazzeffi
BACKGROUND: Our hypothesis was that total intravenous anesthesia (TIVA) is associated with an increase in hypothermia. METHODS: Inclusion criteria were patients from the National Anesthesia Clinical Outcomes Registry undergoing a general anesthetic during 2019. Data collected included patient age, sex, American Society of Anesthesiologists physical status classification system score (ASAPS), duration of anesthetic, use of TIVA, type of procedure, and hypothermia...
2024: Proceedings of the Baylor University Medical Center
#5
JOURNAL ARTICLE
Dennis Ren, Damian Roland
No abstract text is available yet for this article.
April 16, 2024: Pediatric Research
#6
JOURNAL ARTICLE
Vinzent Schulz, Ralf Steinhilper, Jonathan Oltmanns, Sven-A Freibert, Nils Krapoth, Uwe Linne, Sonja Welsch, Maren H Hoock, Volker Schünemann, Bonnie J Murphy, Roland Lill
Maturation of iron-sulfur proteins in eukaryotes is initiated in mitochondria by the core iron-sulfur cluster assembly (ISC) complex, consisting of the cysteine desulfurase sub-complex NFS1-ISD11-ACP1, the scaffold protein ISCU2, the electron donor ferredoxin FDX2, and frataxin, a protein dysfunctional in Friedreich's ataxia. The core ISC complex synthesizes [2Fe-2S] clusters de novo from Fe and a persulfide (SSH) bound at conserved cluster assembly site residues. Here, we elucidate the poorly understood Fe-dependent mechanism of persulfide transfer from cysteine desulfurase NFS1 to ISCU2...
April 16, 2024: Nature Communications
#7
JOURNAL ARTICLE
Romanie Hannah, Richard J P G Chavasse, James Y Paton, Emily Walton, Damian Roland, Steven Foster, Mark D Lyttle
OBJECTIVE: Recovery from acute wheeze and asthma attacks should be supported with safety netting, including treatment advice. We evaluated emergency department (ED) discharge practices for acute childhood wheeze/asthma attacks to describe variation in safety netting and recovery bronchodilator dosing. DESIGN: Two-phase study between June 2020 and September 2021, comprising (1) Departmental discharge practice survey, and (2) Analysis of written discharge instructions for caregivers...
April 16, 2024: Archives of Disease in Childhood
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JOURNAL ARTICLE
Aliki Christodoulou, Spyros Bezantakos, Efstratios Bourtsoukidis, Iasonas Stavroulas, Michael Pikridas, Konstantina Oikonomou, Minas Iakovides, Salwa K Hassan, Mohamed Boraiy, Mostafa El-Nazer, Ali Wheida, Magdy Abdelwahab, Roland Sarda-Estève, Martin Rigler, Giorgos Biskos, Charbel Afif, Agnes Borbon, Mihalis Vrekoussis, Nikos Mihalopoulos, Stéphane Sauvage, Jean Sciare
Greater Cairo, the largest megacity of the Middle East North Africa (MENA) region, is currently suffering from major aerosol pollution, posing a significant threat to public health. However, the main sources of pollution remain insufficiently characterized due to limited atmospheric observations. To bridge this knowledge gap, we conducted a continuous 2-month field study during the winter of 2019-2020 at an urban background site, documenting for the first time the chemical and physical properties of submicron (PM1 ) aerosols...
March 27, 2024: Environment International
#9
JOURNAL ARTICLE
Sonia Marquez-Martinez, Nadine Salisch, Jan Serroyen, Roland Zahn, Selina Khan
Non-replicating adenovirus-based vectors have been broadly used for the development of prophylactic vaccines in humans and are licensed for COVID-19 and Ebola virus disease prevention. Adenovirus-based vectored vaccines encode for one or more disease specific transgenes with the aim to induce protective immunity against the target disease. The magnitude and duration of transgene expression of adenovirus 5- based vectors (human type C) in the host are key factors influencing antigen presentation and adaptive immune responses...
2024: PloS One
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JOURNAL ARTICLE
Nene Kaah Keneh, Sebastien Kenmoe, Arnol Bowo-Ngandji, Jane-Francis Tatah Kihla Akoachere, Hortense Gonsu Kamga, Roland Ndip Ndip, Jean Thierry Ebogo-Belobo, Cyprien Kengne-Ndé, Donatien Serge Mbaga, Nicholas Tendongfor, Jean Paul Assam Assam, Lucy Mande Ndip, Seraphine Nkie Esemu
BACKGROUND: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant cause of morbidity and mortality among neonates admitted to neonatal intensive care units (NICUs). The MRSA colonization of neonates, attributed to various sources, including mothers, healthcare workers, and environmental surfaces, can lead to severe infection, prolonged hospital stays, and even death, imposing substantial economic burdens. Given the pressing need to mitigate MRSA spread in these vulnerable environments, further examination of the subject is warranted...
2024: BioMed Research International
#11
JOURNAL ARTICLE
Lisa L Morselli, Rabia Amjad, Roland James, Tammy L Kindel, Anne E Kwitek, Joni S Williams, Justin L Grobe, Srividya Kidambi
OBJECTIVE: Food insecurity (FI) is associated with poor metabolic health. It is assumed that energy intake and diet quality underlie this association. We tested the hypothesis that dietary factors (quantity and quality) mediate the association of FI with excess weight, waist circumference and glycemic control [glycohemoglobin (A1C)]. METHODS: A mediation analysis was performed on data from the National Health And Nutrition Examination Survey using FI as an independent variable; body mass index (BMI), waist circumference, and A1C as metabolic outcome variables and total energy intake, macronutrients, and diet quality measured by the Healthy Eating Index-2015 (HEI-2015) as potential mediators...
April 6, 2024: Journal of the Endocrine Society
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JOURNAL ARTICLE
Femke Geusens, Hanne Van Uytsel, Lieveke Ameye, Roland Devlieger, Yves Jacquemyn, Caroline Van Holsbeke, Annick Bogaerts
BACKGROUND: Postpartum weight retention (PPWR) has many health risks. Digital self-monitoring of weight can potentially make postpartum weight management easier. We aim to test to what extent the self-monitoring of weight, steps and mental health through an mHealth application increases postpartum weight loss and reduces the odds of substantial PPWR (≥5 kg). METHODS: Participants were mothers in the intervention arm of the INTER-ACT multicenter randomized controlled trial (RCT), an inter-pregnancy lifestyle intervention among mothers with excessive gestational weight gain...
March 2024: Health Promotion Perspectives
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JOURNAL ARTICLE
Alexander F Mericli, Rami Elmorsi, Luis Camacho, Abbas Hassan, David D Krijgh, Gordon Tilney, Heather Lyu, Raymond S Traweek, Russell G Witt, Margaret S Roubaud, Christina L Roland
BACKGROUND: The reconstructive ladder relies mostly on defect size and depth to determine reconstructive technique, however, in actuality, many more variables ultimately inform reconstructive decision making, especially regarding extremity soft tissue sarcoma (eSTS) defects. The purpose of this study was to describe eSTS patients who will most optimally benefit from an advanced method of reconstruction (defined as a pedicled regional flap or free flap) and to create a simple risk assessment scale that can be employed in clinical practice...
April 16, 2024: Journal of Surgical Oncology
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JOURNAL ARTICLE
Amy Berrington de González, Scott A Masten, Parveen Bhatti, Renée Turzanski Fortner, Susan Peters, Tiina Santonen, Marianna G Yakubovskaya, Robert Barouki, Silvia B M Barros, Dinesh Barupal, Laura E Beane Freeman, Gloria M Calaf, Joakim Dillner, Karima El Rhazi, Lin Fritschi, Shoji Fukushima, Lode Godderis, Manolis Kogevinas, Dirk W Lachenmeier, Daniele Mandrioli, Mazvita M Muchengeti, Richard T Niemeier, Jane J Pappas, Jingbo Pi, Mark P Purdue, Elio Riboli, Teresa Rodríguez, Vivi Schlünssen, Lamia Benbrahim-Tallaa, Aline de Conti, Caterina Facchin, Elisa Pasqual, Roland Wedekind, Ayat Ahmadi, Shirisha Chittiboyina, Zdenko Herceg, Shalini Kulasingam, Béatrice Lauby-Secretan, Richard MacLehose, Moez Sanaa, Joachim Schüz, Eero Suonio, Jiri Zavadil, Heidi Mattock, Federica Madia, Mary K Schubauer-Berigan
No abstract text is available yet for this article.
April 12, 2024: Lancet Oncology
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JOURNAL ARTICLE
Serdar Tütüncü, Manuel C Olma, Claudia Kunze, Joanna Dietzel, Johannes Schurig, Michael Rosenkranz, Robert Stingele, Matthias Maschke, Peter U Heuschmann, Paulus Kirchhof, Ulrich Laufs, Darius G Nabavi, Joachim Röther, Götz Thomalla, Roland Veltkamp, Matthias Endres, Karl Georg Haeusler
Heart failure (HF) is associated with poor outcome after stroke, but data from large prospective trials are sparse.We assessed the impact of HF on clinical endpoints in patients hospitalized with acute ischemic stroke or transient ischemic attack (TIA) enrolled in the prospective, multicenter Systematic Monitoring for Detection of Atrial Fibrillation in Patients with Acute Ischemic Stroke (MonDAFIS) trial. HF was defined as left ventricular ejection fraction (LVEF) < 55% or a history of HF on admission...
April 15, 2024: Internal and Emergency Medicine
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JOURNAL ARTICLE
Gerrit Frommeyer, Florian Reinke, Johannes Brachmann, Thorsten Lewalter, Roland Richard Tilz, Stephan Willems, Florian Straube, Ibrahim Akin, Patrick Lugenbiel, Matthias Hochadel, Jochen Senges, Lars Eckardt
BACKGROUND: Catheter ablation of atrial fibrillation and atrial flutter is routinely performed in patients with implantable devices. The aim of the present study was to assess success rates and potential complications in a large registry cohort of patients with cardiac pacemakers. METHODS AND RESULTS: The German Ablation Registry is a nationwide, prospective registry with a 1-year follow-up investigating patients who underwent catheter ablation of supraventricular arrhythmias in 51 German centers...
April 15, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
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JOURNAL ARTICLE
Saiki Sugimoto, Sota Nagai, Kei Ito, Hiroki Takeda, Soya Kawabata, Takehiro Michikawa, Daiki Ikeda, Shinjiro Kaneko, Nobuyuki Fujita
INTRODUCTION: Frailty is an important factor in surgical outcomes. The current study aimed to evaluate the effect of preoperative frailty on postoperative outcomes in older patients with lumbar spinal canal stenosis (LSCS). METHODS: We retrospectively examined 209 patients aged ≥65 years who underwent surgery for LSCS. Health-related quality-of-life (HRQOL) tools, including the Roland-Morris Disability Questionnaire (RDQ), Zurich Claudication Questionnaire (ZCQ), and Japanese Orthopaedic Association Back Pain Evaluation Questionnaire (JOABPEQ), were used in the assessment conducted before surgery and at 6 months and 1 year after surgery...
March 27, 2024: Spine surgery and related research
#18
JOURNAL ARTICLE
Mark Alfano, Ehsan Abedin, Ritsaart Reimann, Marinus Ferreira, Marc Cheong
Artificial intelligence (AI) systems are increasingly being used not only to classify and analyze but also to generate images and text. As recent work on the content produced by text and image Generative AIs has shown (e.g., Cheong et al., 2024, Acerbi & Stubbersfield, 2023), there is a risk that harms of representation and bias, already documented in prior AI and natural language processing (NLP) algorithms may also be present in generative models. These harms relate to protected categories such as gender, race, age, and religion...
2024: Ethics and Information Technology
#19
JOURNAL ARTICLE
Bernard Montalvan, Vincent Guillard, Sonia Ramos-Pascual, Floris van Rooij, Mo Saffarini, Alexis Nogier
BACKGROUND: The epidemiology of musculoskeletal injuries at the Australian Open, Wimbledon, and US Open tennis tournaments has been investigated in recent studies; however, there is no published literature on the incidence of musculoskeletal injuries at the French Open. PURPOSE: To describe the incidence, location, and type of musculoskeletal injuries in tennis players during the French Open tournament from 2011 to 2022. STUDY DESIGN: Descriptive epidemiology study...
April 2024: Orthopaedic Journal of Sports Medicine
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JOURNAL ARTICLE
Andrew S P Sharp, David E Kandzari, Raymond R Townsend, Kazuomi Kario, Felix Mahfoud, Michael A Weber, Roland E Schmieder, Konstantinos Tsioufis, Michael Böhm, James W Choi, Minglei Liu, Vanessa DeBruin, David P Lee
BACKGROUND: Catheter-based renal sympathetic denervation (RDN) reduced blood pressure (BP) in multiple randomized sham-controlled trials of patients with uncontrolled hypertension (HTN). We tested proof-of-concept for a more selective treatment strategy, exclusively targeting these areas to improve the efficiency of the procedure. METHODS: The SPYRAL DYSTAL Pilot study was designed to mirror the SPYRAL HTN-OFF MED Pivotal study, enabling comparison with a propensity score adjusted active-control group...
April 10, 2024: Cardiovascular Revascularization Medicine: Including Molecular Interventions
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