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Justine Fletcher, Bridget Hamilton, Stuart Kinner, Georgina Sutherland, Kylie King, Juan Jose Tellez, Carol Harvey, Lisa Brophy
There has been a shift towards provision of mental health care in community-based settings in Australia. However, hospitals continue to care for people in acute mental health wards. An increasing proportion of the people in wards are admitted involuntarily, subject to restrictions of movement to minimize risk of harm to self and others. In response to concerns about the safety of people absconding from care, Queensland Health introduced a policy requiring all acute mental health wards in the State to be locked...
December 5, 2018: International Journal of Mental Health Nursing
Hai-Lei Kou, Wen-Zhou Diao, Tao Liu, Dan-Liang Yang, Suksun Horpibulsuk
The behavior of open-ended pipe piles is different from that of closed-ended pipe piles due to the soil plugging effect. In this study, a series of field tests were conducted to investigate the behavior of open-ended prestressed high-strength concrete (PHC) pipe piles installed into clay. Two open-ended PHC pipe piles were instrumented with Fiber Bragg Grating (FBG) sensors and jacked into clay for subsequent static loading tests. Soil plug length of the test piles was continuously measured during installation, allowing for calculation of the incremental filling ratio...
December 1, 2018: Sensors
Richard C Kolanczyk, Jeffrey S Denny, Barbara R Sheedy, Patricia K Schmieder, Mark A Tapper
A representative group of multicyclic aromatic hydrocarbons (MAHC) which can be further classified as bridged-ring (bridged-MAHC) or fused-ring (fused-MAHC) were examined for their ability to interact with the estrogen receptor of rainbow trout (rtER) in a hepatic cytosolic estrogen receptor competitive binding assay (cyto rtERαβ) and the vitellogenin (Vtg) mRNA gene activation liver slice assay. All five fused-MAHCs; naphthalene (NAFT), fluorene (FE), Fluoranthene (FAT), pyrene (PY), and 9,10-dihydroanthracene (DAC) had no estrogenic activity in the in vitro assays used...
November 26, 2018: Aquatic Toxicology
Jean T Negou, Juan Hu, Xiangpeng Li, Christopher J Easley
In this work, we expand upon our recently developed droplet-based sample chopping concepts by introducing a multiplexed fluidic micro-chopper device (μChopper). Six aqueous input channels were integrated with a single oil input, and each of these seven channels was controlled by a pneumatic valve for automated sampling through software control. This improved design, while maintaining high precision in valve-based droplet generation at bandwidths of 0.03 to 0.05 Hz, enabled a variety of analytical modes to be employed on-chip compared to previous devices limited to sample/reference alternations...
July 28, 2018: Analytical Methods: Advancing Methods and Applications
Ling Wang, Charlie Y Mo, Michael R Wasserman, Jakob T Rostøl, Luciano A Marraffini, Shixin Liu
Adaptive immune systems must accurately distinguish between self and non-self in order to defend against invading pathogens while avoiding autoimmunity. Type III CRISPR-Cas systems employ guide RNA to recognize complementary RNA targets, which triggers the degradation of both the invader's transcripts and their template DNA. These systems can broadly eliminate foreign targets with multiple mutations but circumvent damage to the host genome. To explore the molecular basis for these features, we use single-molecule fluorescence microscopy to study the interaction between a type III-A ribonucleoprotein complex and various RNA substrates...
November 27, 2018: Molecular Cell
Jingtao Dong, Rongsheng Lu, Tengda Zhang, Lei Yang, Yuzhong Zhang, Zhouling Wu, Jian Chen
Surface thermal lensing (STL) is a high sensitive pump-probe technique for photothermal characterization of weakly absorbing defects in optical materials. Commonly, the frequency modulation is applied in the pump beam, and the STL signal that appears as small modulation on top of an intense background is then detected on the probe beam by lock-in amplification. However, the lock-in detection by filtering the signal in the frequency domain results in low efficiency in the STL, preventing investigations of the large area surfaces...
November 2018: Review of Scientific Instruments
Guohai Zhang, Liangping Li, Zhenhao Shi, Yang Yang, Yiming Wu, Huanhuan Song, Jingxian Long, Xing Lu, Shulan Zeng, Hongbin Sun, Zhen-Feng Chen, Hong Liang, Yang Peng
The real-time tracking of localization and dynamics of small molecules in organelles helps to understand their function and lock their potential targets at the subcellular resolution. To identify the mitochondria-targeting effect of small molecules (NA-17 and NA-2a) in cancer cells, we used mass spectrometry to study the distribution and enrichment of small molecules in mitochondria and the residual cytoplasm, which enables to trace action process of therapeutic molecules. Colocalization analysis with an image-guided way suggests that both NA-17 and NA-2a have mitochondria-targeting effect...
November 30, 2018: Chembiochem: a European Journal of Chemical Biology
Ylec M Cardenas, Aparna Prabhu, Yan Zhang
No abstract text is available yet for this article.
November 27, 2018: Neurology
Richarj Mondal, Basabendra Roy, Bipul Pal, Bhavtosh Bansal
We present a simple but mathematically complete first-principles theory for the pump-probe differential reflectivity experiment at negative delay (probe preceding the pump) to show how it gives information about the perturbed-free-induction-decay of coherent polarization. The calculation, involving the optical Bloch equations to describe the induced polarization and the Ewald-Oseen idea to calculate the reflected signal as a consequence of the free oscillations of perturbed dipoles, also explicitly includes the process of lock-in detection of a double-chopped signal after it has passed through a monochromator...
November 26, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Jiarong Qin, Ruihong Dai, Yao Li, Yafei Meng, Yongbing Xu, Shining Zhu, Fengqiu Wang
A high repetition-rate actively mode-locked thulium fiber laser is demonstrated where an electro-optic lithium niobate phase modulator is used to synchronize the longitudinal modes in the cavity. The repetition rate of the actively mode-locked laser is tunable from 14.6 MHz to 19 GHz, where the 19 GHz pulses exhibit a super-mode suppression ratio of 46 dB. Furthermore, the output pulse width could be manipulated through finely controlling the detuning frequency or repetition rate. We have also experimentally observed rational harmonic mode-locking in the laser and obtained 14 GHz and 21 GHz repetition rate pulses using a 7 GHz modulating signal...
October 1, 2018: Optics Express
Tadeusz Skoczkowski, Sławomir Bielecki, Arkadiusz Węglarz, Magdalena Włodarczak, Piotr Gutowski
This article addresses the impact of the European Union Emissions Trading System (EU ETS) on Poland's conventional energy sector in 2008-2020 and further till 2050. Poland is a country with over 80% dependence on coal in the power sector being under political pressure of the European Union's (EU) ambitious climate policy. The impact of the increase of the European Emission Allowance (EUA) price on fossil fuel power sector has been modelled for different scenarios. The innovation of this article consists in proposing a methodology of estimation actual costs and benefits of power stations in a country with a heavily coal-dependent power sector in the process of transition to a low-carbon economy...
2018: Mitigation and adaptation strategies for global change
Shivanthan A C Yohanandan, Isabell Kiral-Kornek, Jianbin Tang, Benjamin S Mshford, Umar Asif, Stefan Harrer
Motor imagery (MI) based Brain-Computer Interfaces (BCIs) are a viable option for giving locked-in syndrome patients independence and communicability. BCIs comprising expensive medical-grade EEG systems evaluated in carefully-controlled, artificial environments are impractical for take-home use. Previous studies evaluated low-cost systems; however, performance was suboptimal or inconclusive. Here we evaluated a low-cost EEG system, OpenBCI, in a natural environment and leveraged neurofeedback, deep learning, and wider temporal windows to improve performance...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Mashael AlSaleh, Roger Moore, Heidi Christensen, Mahnaz Arvaneh
People who are severely disabled (e.g Locked-in patients) need a communication tool translating their thoughts using their brain signals. This technology should be intuitive and easy to use. To this line, this study investigates the possibility of discriminating between imagined speech and two types of non-speech tasks related to either a visual stimulus or relaxation. In comparison to previous studies, this work examines a variety of different words with only single imagination in each trial. Moreover, EEG data are recorded from a small number of electrodes using a low-cost portable EEG device...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Alexey Petrushin, Giacinto Barresi, Leonardo S Mattos
This paper describes the implementation and the preliminary evaluation of a novel interaction solution for people with severe motor impairments, and particularly for those affected by Amyotrophic Laterals Sclerosis (ALS) in Locked-In State (LIS): patients able to control only the ocular muscles. The proposed communication approach allows the person to control a laser beam and interact with the environment or interlocutors in an intuitive way by pointing at objects through their gaze. For this, a tip-tilt laser control device was developed and mounted on a small robot equipped with a high definition video camera...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Q Rosa So, Tao Yang, Kok Soon Phua, Juanhong Yu, Valerie Toh, Wai Hoe Ng, Kai Keng Ang
Non-invasive brain computer interface (BCI) has been successfully used to control cursors, helicopters and robotic arms. However, this technology is not widely adopted by people with late-stage amyotrophic lateral sclerosis (ALS) due to poor effectiveness. In this study, we attempt to assess the cognitive state of a completely locked-in ALS subject, and her ability to use motor imagery-based BCI for control. The subject achieves above chance level accuracies for both open loop (62.2%) and closed-loop (68.7%) 2-class movement vs...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
J Arnin, D Kahani, H Lakany, B A Conway
Brain-computer interface (BCI) has been widely introduced in many medical applications. One of the main challenges in BCI is to run the signal processing algorithms in real-time which is challenging and usually comes with high processing unit costs. BCIs based on motor imagery task are introduced for severe neurological diseases especially locked-in patients. A common concept is to detect one's movement intention and use it to control external devices such as wheelchair or rehabilitation devices. In real-time BCI, running the signal processing algorithms might not always be possible due to the complexity of the algorithms...
July 2018: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Yoji Okahara, Kouji Takano, Masahiro Nagao, Kiyohiko Kondo, Yasuo Iwadate, Niels Birbaumer, Kenji Kansaku
Brain-computer interfaces (BCIs) enable communication with others and allow machines or computers to be controlled in the absence of motor activity. Clinical studies evaluating neural prostheses in amyotrophic lateral sclerosis (ALS) patients have been performed; however, to date, no study has reported that ALS patients who progressed from locked-in syndrome (LIS), which has very limited voluntary movement, to a completely locked-in state (CLIS), characterized by complete loss of voluntary movements, were able to continue controlling neural prostheses...
November 14, 2018: Scientific Reports
Vijay Viswam, Raziyeh Bounik, Amir Shadmani, Jelena Dragas, Cedar Urwyler, Julia Alicia Boos, Marie Obien, Jan Muller, Yihui Chen, Andreas Hierlemann
A monolithic multi-functional CMOS microelectrode array system was developed that enables label-free electrochemical impedance spectroscopy of cells in-vitro at high spatiotemporal resolution. The electrode array includes 59,760 platinum microelectrodes, densely packed within a 4.5 mm×2.5 mm sensing region at a pitch of 13.5 μm. 32 on-chip lock-in amplifiers can be used to measure the impedance of any arbitrarily chosen subset of electrodes in the array. A sinusoidal voltage, generated by an on-chip waveform generator with a frequency range from 1 Hz to 1 MHz, was applied to the reference electrode...
November 12, 2018: IEEE Transactions on Biomedical Circuits and Systems
Trine Tamberg, Zebin Hong, Daphné De Schepper, Signe Skovbjerg, Daniel M Dupont, Lars Vitved, Christine R Schar, Karsten Skjoedt, Lotte K Vogel, Jan K Jensen
Matriptase is a member of the type-II transmembrane serine protease (TTSP) 1 family and plays a crucial role in the development and maintenance of epithelial tissues. As all chymotrypsin-like serine proteases, matriptase is synthesized as a zymogen (proform), requiring a cleavage event for full activity. Recent studies suggest that the zymogen of matriptase possesses enough catalytic activity to not only facilitate autoactivation, but also carry out its in vivo functions, which include activating several proteolytic and signaling cascades...
November 8, 2018: Journal of Biological Chemistry
Frederic Deschamps, Steven Yevich, Guillaume Gravel, Charles Roux, Antoine Hakime, Thierry de Baère, Lambros Tselikas
Interventional radiology expertise in image guidance has expanded the treatment options for cancer patients with unstable osseous disease. Percutaneous fixation by internal cemented screw (FICS) describes the technique by which the interventional radiologist stabilizes a fracture or impending fracture with the percutaneous placement of a cannulated screw that is locked in position by polymethyl methacrylate cement. The durable metallic screws provide added resistance to torque and tension stresses that complement the axial compression resistance of cement...
October 2018: Seminars in Interventional Radiology
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