keyword
https://read.qxmd.com/read/38536869/study-protocol-identifying-transcriptional-regulatory-alterations-of-chronic-effects-of-blast-and-disturbed-sleep-in-united-states-veterans
#1
JOURNAL ARTICLE
Molly J Sullan, Kelly A Stearns-Yoder, Zhaoyu Wang, Andrew J Hoisington, Adam D Bramoweth, Walter Carr, Yongchao Ge, Hanga Galfalvy, Fatemah Haghighi, Lisa A Brenner
Injury related to blast exposure dramatically rose during post-911 era military conflicts in Iraq and Afghanistan. Mild traumatic brain injury (mTBI) is among the most common injuries following blast, an exposure that may not result in a definitive physiologic marker (e.g., loss of consciousness). Recent research suggests that exposure to low level blasts and, more specifically repetitive blast exposure (RBE), which may be subconcussive in nature, may also impact long term physiologic and psychological outcomes, though findings have been mixed...
2024: PloS One
https://read.qxmd.com/read/38535426/in-season-test-retest-reliability-of-visual-smooth-pursuit-eyeguide-focus-baseline-assessment-in-female-and-male-field-sport-athletes
#2
JOURNAL ARTICLE
Ayrton Walshe, Ed Daly, Alan J Pearce, Lisa Ryan
Sport-related concussions (SRCs) are a mild traumatic brain injury (mTBI) that induces transient symptoms in athletes. These symptoms provide avenues for developing emerging technologies to diagnose SRCs, in particular ocular and vestibular dysfunction. The following study aims to assess the reliability of visual smooth-pursuit technology (EyeGuide Focus) in amateur field-sport athletes. A convenience sample of 30 mixed-gender athletes (mean age = 24.89 ± 6.81 years) completed two testing sessions separated by 2-7 days...
March 4, 2024: Journal of Functional Morphology and Kinesiology
https://read.qxmd.com/read/38535293/integrative-analysis-of-cytokine-and-lipidomics-datasets-following-mild-traumatic-brain-injury-in-rats
#3
JOURNAL ARTICLE
Alexis N Pulliam, Alyssa F Pybus, David A Gaul, Samuel G Moore, Levi B Wood, Facundo M Fernández, Michelle C LaPlaca
Traumatic brain injury (TBI) is a significant source of disability in the United States and around the world and may lead to long-lasting cognitive deficits and a decreased quality of life for patients across injury severities. Following the primary injury phase, TBI is characterized by complex secondary cascades that involve altered homeostasis and metabolism, faulty signaling, neuroinflammation, and lipid dysfunction. The objectives of the present study were to (1) assess potential correlations between lipidome and cytokine changes after closed-head mild TBI (mTBI), and (2) examine the reproducibility of our acute lipidomic profiles following TBI...
February 21, 2024: Metabolites
https://read.qxmd.com/read/38534474/engineered-dual-antioxidant-enzyme-complexes-targeting-icam-1-on-brain-endothelium-reduce-brain-injury-associated-neuroinflammation
#4
JOURNAL ARTICLE
Brian M Leonard, Vladimir V Shuvaev, Trent A Bullock, Kalpani N Udeni Galpayage Dona, Vladimir R Muzykantov, Allison M Andrews, Servio H Ramirez
The neuroinflammatory cascade triggered by traumatic brain injury (TBI) represents a clinically important point for therapeutic intervention. Neuroinflammation generates oxidative stress in the form of high-energy reactive oxygen and nitrogen species, which are key mediators of TBI pathology. The role of the blood-brain barrier (BBB) is essential for proper neuronal function and is vulnerable to oxidative stress. Results herein explore the notion that attenuating oxidative stress at the vasculature after TBI may result in improved BBB integrity and neuroprotection...
February 21, 2024: Bioengineering
https://read.qxmd.com/read/38534355/recent-research-trends-in-neuroinflammatory-and-neurodegenerative-disorders
#5
REVIEW
Jessica Cohen, Annette Mathew, Kirk D Dourvetakis, Estella Sanchez-Guerrero, Rajendra P Pangeni, Narasimman Gurusamy, Kristina K Aenlle, Geeta Ravindran, Assma Twahir, Dylan Isler, Sara Rukmini Sosa-Garcia, Axel Llizo, Alison C Bested, Theoharis C Theoharides, Nancy G Klimas, Duraisamy Kempuraj
Neuroinflammatory and neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD), traumatic brain injury (TBI) and Amyotrophic lateral sclerosis (ALS) are chronic major health disorders. The exact mechanism of the neuroimmune dysfunctions of these disease pathogeneses is currently not clearly understood. These disorders show dysregulated neuroimmune and inflammatory responses, including activation of neurons, glial cells, and neurovascular unit damage associated with excessive release of proinflammatory cytokines, chemokines, neurotoxic mediators, and infiltration of peripheral immune cells into the brain, as well as entry of inflammatory mediators through damaged neurovascular endothelial cells, blood-brain barrier and tight junction proteins...
March 14, 2024: Cells
https://read.qxmd.com/read/38534205/meningeal-damage-and-interface-astroglial-scarring-in-the-rat-brain-exposed-to-a-laser-induced-shock-wave-s
#6
JOURNAL ARTICLE
Satoko Kawauchi, Akemi Kono, Yuriko Muramatsu, Grant Hennes, Shuta Seki, Susumu Tominaga, Yasue Haruyama, Yukari Komuta, Izumi Nishidate, Susumu Matsukuma, Yushan Wang, Shunichi Sato
In the past decade, signature clinical neuropathology of blast-induced traumatic brain injury has been under intense debate, but interface astroglial scarring (IAS) seems to be convincing. In this study, we examined whether IAS could be replicated in the rat brain exposed to a laser-induced shock wave(s) (LISW[s]), a tool that can produce a pure shock wave (primary mechanism) without dynamic pressure (tertiary mechanism). Under certain conditions, we observed astroglial scarring in the subpial glial plate (SGP), grey-white matter junctions (GM-WM), ventricular wall (VW) and regions surrounding cortical blood vessels, accurately reproducing clinical IAS...
March 27, 2024: Journal of Neurotrauma
https://read.qxmd.com/read/38533717/examining-the-relationship-between-head-trauma-and-opioid-use-disorder-a-systematic-review
#7
JOURNAL ARTICLE
Ali Abid, Maria Paracha, Iva Çepele, Awais Paracha, Joseph Rueve, Akbar Fidahussain, Humza Rehman, McKimmon Engelhardt, Noor Alyasiry, Zohair Siddiqui, Satvik Vasireddy, Bishal Kadariya, Nikith Rao, Rohan Das, Wilson Rodriguez, Dixie Meyer
OBJECTIVE: To examine recent literature and determine common clinical risk factors between antecedent traumatic brain injury (TBI) and the following development of opioid misuse and provide a framework for clinical identification of at-risk subjects and evaluate potential treatment implications within this association. DESIGN: A comprehensive systematic literature search of PubMed was conducted for articles between 2000 and December 2022. Studies were included if the human participant had any head trauma exposure and any chronic opioid use or dependence...
2024: Journal of Opioid Management
https://read.qxmd.com/read/38533630/strongly-adhesive-self-healing-hemostatic-hydrogel-for-the-repair-of-traumatic-brain-injury
#8
JOURNAL ARTICLE
Zuoxiang Dong, Jihu Zhao, Jian Xu, Wenshuai Deng, Peng Sun
With wide clinical demands, therapies for traumatic brain injury (TBI) are a major problem in surgical procedures and after major trauma. Due to the difficulty in regeneration of neurons or axons after injury, as well as the inhibition of blood vessel growth by the formation of neural scars, existing treatment measures have limited effectiveness in repairing brain tissue. Herein, the biomultifunctional hydrogels are developed for TBI treatment based on the Schiff base reaction of calcium ion (Ca2+ )-cross-linked oxidized sodium alginate (OSA) and carboxymethyl chitosan (CMCS)...
March 27, 2024: Biomacromolecules
https://read.qxmd.com/read/38533491/identification-of-novel-blood-based-extracellular-vesicles-biomarker-candidates-with-potential-specificity-for-traumatic-brain-injury-in-polytrauma-patients
#9
JOURNAL ARTICLE
Cora R Schindler, Jason A Hörauf, Birte Weber, Inna Schaible, Ingo Marzi, Dirk Henrich, Liudmila Leppik
OBJECTIVE: The goal of this study was to identify changes in extracellular vesicles (EV) surface proteins specific to traumatic brain injury (TBI), which could be used as a diagnostic and prognostic tool in polytrauma patients. SUMMARY BACKGROUND DATA: Known serum TBI-specific biomarkers (S100B, NSE, and GFAP), which can predict the severity and outcome of isolated TBI, lose their predictive value in the presence of additional extracranial injuries. Extracellular vesicles (EVs) are released from cells in response to various stimuli and carry specific cargo/surface molecules that could be used for tracking injury-responding cells...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38533412/editorial-neurological-and-neuropsychiatric-disorders-affecting-military-personnel-and-veterans
#10
EDITORIAL
Chen Lin, Mary Jo Pugh, Venkatagiri Krishnamurthy, Lisa C Krishnamurthy, Willliam C Walker
No abstract text is available yet for this article.
2024: Frontiers in Neurology
https://read.qxmd.com/read/38532543/rack1-promotes-autophagy-via-the-perk-signaling-pathway-to-protect-against-traumatic-brain-injury-in-rats
#11
JOURNAL ARTICLE
Haibo Ni, Xugang Kan, Qin Rui, Yang Zhang, Weiwei Zhai, Baole Zhang, Zhengquan Yu
AIMS: Neuronal cell death is a primary factor that determines the outcome after traumatic brain injury (TBI). We previously revealed the importance of receptor for activated C kinase (RACK1), a multifunctional scaffold protein, in maintaining neuronal survival after TBI, but the specific mechanism remains unclear. The aim of this study was to explore the mechanism underlying RACK1-mediated neuroprotection in TBI. METHODS: TBI model was established using controlled cortical impact injury in Sprague-Dawley rats...
March 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38532172/simulating-cerebral-edema-and-ischemia-after-traumatic-acute-subdural-hematoma-using-triphasic-swelling-biomechanics
#12
JOURNAL ARTICLE
Andrew V Basilio, Delin Zeng, Leanne A Pichay, Gerard A Ateshian, Peng Xu, Steve A Maas, Barclay Morrison
Poor outcome following traumatic acute subdural hematoma (ASDH) is associated with the severity of the primary injury and secondary injury including cerebral edema and ischemia. However, the underlying secondary injury mechanism contributing to elevated intracranial pressure (ICP) and high mortality rate remains unclear. Cerebral edema occurs in response to the exposure of the intracellular fixed charge density (FCD) after cell death, causing ICP to increase. The increased ICP from swollen tissue compresses blood vessels in adjacent tissue, restricting blood flow and leading to ischemic damage...
March 26, 2024: Annals of Biomedical Engineering
https://read.qxmd.com/read/38531909/preso-enhances-mglur1-mediated-excitotoxicity-by-modulating-the-phosphorylation-of-mglur1-homer1-complex-and-facilitating-an-er-stress-after-traumatic-brain-injury
#13
JOURNAL ARTICLE
Zhuoyuan Zhang, Xiangyu Gao, Zhicheng Tian, Erwan Yang, Yutao Huang, Dan Liu, Shuhui Dai, Haofuzi Zhang, Mingdong Bao, Xiaofan Jiang, Xin Li, Peng Luo
Glutamate receptor (GluR)-mediated excitotoxicity is an important mechanism causing delayed neuronal injury after traumatic brain injury (TBI). Preso, as a core scaffolding protein of postsynaptic density (PSD), is considered an important regulator during excitotoxicity and TBI and combines with glutamate receptors to form functional units for excitatory glutamatergic neurotransmission, and elucidating the mechanisms of these functional units will provide new targets for the treatment of TBI. As a multidomain scaffolding protein, Preso directly interacts with metabotropic GluR (mGluR) and another scaffold protein, Homer...
March 26, 2024: Cell Death Discovery
https://read.qxmd.com/read/38531908/association-between-mammillary-body-atrophy-and-memory-impairment-in-retired-athletes-with-a-history-of-repetitive-mild-traumatic-brain-injury
#14
JOURNAL ARTICLE
Mari Miyata, Keisuke Takahata, Yasunori Sano, Yasuharu Yamamoto, Shin Kurose, Manabu Kubota, Hironobu Endo, Kiwamu Matsuoka, Kenji Tagai, Masaki Oya, Kosei Hirata, Fumie Saito, Masaru Mimura, Koji Kamagata, Shigeki Aoki, Makoto Higuchi
Cognitive dysfunction, especially memory impairment, is a typical clinical feature of long-term symptoms caused by repetitive mild traumatic brain injury (rmTBI). The current study aims to investigate the relationship between regional brain atrophy and cognitive impairments in retired athletes with a long history of rmTBI. Overall, 27 retired athletes with a history of rmTBI (18 boxers, 3 kickboxers, 2 wrestlers, and 4 others; rmTBI group) and 23 age/sex-matched healthy participants (control group) were enrolled...
March 26, 2024: Scientific Reports
https://read.qxmd.com/read/38531791/melatonin-s-protective-effects-on-neurons-in-an-in-vitro-cell-injury-model
#15
JOURNAL ARTICLE
Wei Gu, Mimi Wu, Shihe Cui, Jinhua Bo, Hao Wu
BACKGROUND: Currently, the role of melatonin (MT) in neuronal damage remains unclear and this study aimed to explore the protective effects of MT on neurons in an in vitro cell injury model. METHODS: The Sprague Dawley (SD) rat traumatic brain injury (TBI) model was prepared, and brain tissue extract (BTE) from the injured area were generated. To establish a cell injury model in vitro , the BTE was added to the culture medium during the neuron culture process. MT was introduced into the culture medium of the cell injury model to observe its protective effects on neurons...
March 2024: Discovery Medicine
https://read.qxmd.com/read/38531484/inhibition-of-soluble-epoxide-hydrolase-as-a-therapeutic-approach-for-blood-brain-barrier-dysfunction
#16
JOURNAL ARTICLE
Shuo Li, Huijia Song, Yanping Sun, Yongjun Sun, Huimin Zhang, Zibin Gao
The blood-brain barrier (BBB) is a protective semi-permeable structure that regulates the exchange of biomolecules between the peripheral blood and the central nervous system (CNS). Due to its specialized tight junctions and low vesicle trafficking, the BBB strictly limits the paracellular passage and transcellular transport of molecules to maintain the physiological condition of brain tissues. BBB breakdown is associated with many CNS disorders. Soluble epoxide hydrolase (sEH) is a hydrolase enzyme that converts epoxy-fatty acids (EpFAs) to their corresponding diols and is involved in the onset and progression of multiple diseases...
March 24, 2024: Biochimie
https://read.qxmd.com/read/38531165/enigma-s-simple-seven-recommendations-to-enhance-the-reproducibility-of-resting-state-fmri-in-traumatic-brain-injury
#17
REVIEW
Karen Caeyenberghs, Phoebe Imms, Andrei Irimia, Martin M Monti, Carrie Esopenko, Nicola L de Souza, Juan F Dominguez D, Mary R Newsome, Ekaterina Dobryakova, Andrew Cwiek, Hollie A C Mullin, Nicholas J Kim, Andrew R Mayer, Maheen M Adamson, Kevin Bickart, Katherine M Breedlove, Emily L Dennis, Seth G Disner, Courtney Haswell, Cooper B Hodges, Kristen R Hoskinson, Paula K Johnson, Marsh Königs, Lucia M Li, Spencer W Liebel, Abigail Livny, Rajendra A Morey, Alexandra M Muir, Alexander Olsen, Adeel Razi, Matthew Su, David F Tate, Carmen Velez, Elisabeth A Wilde, Brandon A Zielinski, Paul M Thompson, Frank G Hillary
Resting state functional magnetic resonance imaging (rsfMRI) provides researchers and clinicians with a powerful tool to examine functional connectivity across large-scale brain networks, with ever-increasing applications to the study of neurological disorders, such as traumatic brain injury (TBI). While rsfMRI holds unparalleled promise in systems neurosciences, its acquisition and analytical methodology across research groups is variable, resulting in a literature that is challenging to integrate and interpret...
March 5, 2024: NeuroImage: Clinical
https://read.qxmd.com/read/38530653/national-athletic-trainers-association-bridge-statement-management-of-sport-related-concussion
#18
JOURNAL ARTICLE
Steven P Broglio, Johna K Register-Mihalik, Kevin M Guskiewicz, John J Leddy, Alejandra Merriman, Tamara C Valovich McLeod
OBJECTIVE: To provide athletic trainers and team physicians with updated recommendations to the 2014 National Athletic Trainers' Association (NATA) concussion position statement regarding concussion management, specifically in the areas of education, assessment, prognostic factors, mental health, return to academics, physical activity, rest, treatment, and return to sport. BACKGROUND: Athletic trainers have benefited from the 2 previous NATA position statements on concussion management, and although the most recent NATA position statement is a decade old, knowledge gains in the medical literature warrant updating several (but not all) recommendations...
March 1, 2024: Journal of Athletic Training
https://read.qxmd.com/read/38530414/bone-flap-binding-and-transposition-a-method-for-bone-reconstruction-in-cranial-burst-fractures-and-early-stage-growing-skull-fractures
#19
JOURNAL ARTICLE
Hongbin Cao, Genrui Guo
PURPOSE: To introduce a method of cranial bone reconstruction for cranial burst fractures and early-stage growing skull fractures, named bone flap binding and transposition. METHODS: Cranial burst fractures, severe head injuries predominantly observed in infants, are characterized by widely diastatic skull fractures coupled with acute extracranial cerebral herniation beneath an intact scalp through ruptured dura mater. These injuries can develop into growing skull fractures...
March 26, 2024: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/38530411/impact-of-early-follow-up-ct-in-the-conservative-management-of-traumatic-brain-injury-on-surgical-decision-making-a-retrospective-single-center-analysis-with-special-respect-to-coagulopathy
#20
JOURNAL ARTICLE
Mats L Moskopp, Dag Moskopp, Lennart W Sannwald
INTRODUCTION: Initial management of traumatic brain injury (TBI) without immediate need for surgical therapy varies across centers. The additional value of routine repeat cranial computerized tomography (CT) to neurological monitoring is controversial. This retrospective study investigates the impact of routine follow-up CT after 6 h (CT6h) in initially conservatively managed TBI on surgical decision making. Furthermore, the impact of coagulopathy on lesion size and progression was examined...
March 26, 2024: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
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