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Stephanie Jarvi Steele, Todd J Farchione, Clair Cassiello-Robbins, Amantia Ametaj, Sophia Sbi, Shannon Sauer-Zavala, David H Barlow
OBJECTIVE: This study aimed to examine whether the Unified Protocol (UP), a transdiagnostic cognitive-behavioral therapy for emotional disorders (i.e., anxiety, mood, and related disorders), is efficacious in the treatment of co-occurring emotional disorders compared to established single disorder protocols (SDPs) that target specific disorders (e.g., panic disorder). METHOD: Participants included 179 adults seeking outpatient psychotherapy. Participant age ranged from 18 to 66 years, with an average of 30...
August 3, 2018: Journal of Psychiatric Research
Edwin J Burns, Jeremy Tree, Alice H D Chan, Hong Xu
It has recently been suggested that the other race effect (ORE), whereby own race faces are recognised better than those of other races, can be abolished by bilingualism. Bilingualism, however, is not a categorical variable but can vary dramatically in proficiency across the two languages. We therefore hypothesised that increasing bilingual proficiency should be associated with a diminishing ORE. To test this, we asked a group of bilingual Singaporean Chinese individuals to complete the Asian and Caucasian Cambridge Face Memory Tests...
August 10, 2018: Vision Research
Kara C LaMattina, Sarah M Escott, Julia F Malalis, David Mai, Yosuke Harada, Debra A Goldstein
PURPOSE: To detect any correlation between race and sex and the side effects of methotrexate in uveitis treatment. METHODS: Retrospective review of patients seen at Northwestern Memorial Hospital between August 2012 and September 2014 with a history of MTX treatment for uveitis. Demographic, treatment, and side-effect data were collected for each patient. RESULTS: Ninety-seven patients were included (25 males, 72 females). Twenty-eight patients reported African American race, 60 reported Caucasian race, and the remaining 9 reported Asian, Hispanic, or Arabic ethnicity...
August 13, 2018: Ocular Immunology and Inflammation
Zoe Garoufalia, Nikolaos Machairas, Ioannis D Kostakis, Aliki Liakea, Petros Tsaparas, George Liapis, Georgios C Sotiropoulos
Hepatic epithelioid angiomyolipoma (HEAML) is a rare mesenchymal tumor that has been reported to have malignant potential. We herein describe a rare case of atypical HEAML. A 43-year-old Caucasian male patient visited his general practitioner due to a productive cough persisting for >2 months. During evaluation with several imaging tests, a chest computed tomography (CT) incidentally revealed a well-demarcated lesion in the caudate lobe of the liver, sized 7 cm. An abdominal magnetic resonance imaging examination confirmed the findings of the CT...
August 2018: Molecular and Clinical Oncology
Min Wen, Bo Zhou, Xin Lin, Yunhua Chen, Jialei Song, Yanmei Li, Eldad Zacksenhaus, Yaacov Ben-David, Xiaojiang Hao
Objectives: The aim of the present study was to define the potential relationship between xeroderma pigmentosum group D (XPD) Lys751Gln polymorphisms and the risk of leukemia. Methods: A comprehensive search of Pubmed, Web of Science, EBSCO, the Cochrane Library and China National Knowledge Infrastructure was conducted to identify original articles published before March 2017 concerning the association between XPD Lys751Gln polymorphisms and leukemia risk. A literature quality assessment was performed using the Newcastle-Ottawa Scale...
2018: Frontiers in Genetics
M Sean Peach, Daniel M Trifiletti, Carolyn Vachani, Karen Arnold-Korzeniowski, Christina Bach, Margaret Hampshire, James M Metz, Christine E Hill-Kayser
Purpose: Head and neck cancer is occurring in an increasingly younger patient population, with treatment toxicity that can cause significant morbidity. Using a patient guided, Internet-based survivorship care plan program, we obtained and looked at patterns of patient-reported outcomes data from survivors seeking information after treatment for head and neck cancer. Methods: The Internet-based OncoLife and LIVESTRONG Care Plan programs were employed, which design unique survivorship care plans based on patient-reported data...
2018: Patient related Outcome Measures
Nyarai Desiree Soko, Emile Chimusa, Collen Masimirembwa, Collet Dandara
Studies in Caucasian and Asian populations consistently associated interindividual and interethnic variability in rosuvastatin pharmacokinetics to the polymorphisms SLCO1B1 c.521T>C (rs4149056 p. Val174Ala) and ABCG2 c.421C>A (rs2231142, p. Gln141Lys). To investigate the pharmacogenetics of rosuvastatin in African populations, we first screened 785 individuals from nine ethnic African populations for the SLCO1B1 c.521C and ABCG2 c.421CA variants. This was followed by sequencing whole exomes from individuals of African Bantu descent, who participated in a 20 mg rosuvastatin pharmacokinetic trial in Harare Zimbabwe...
August 13, 2018: Pharmacogenomics Journal
Zara Izadi, Patricia P Katz, Gabriela Schmajuk, Julie Gandrup, Jing Li, Milena Gianfrancesco, Jinoos Yazdany
OBJECTIVE: Most studies evaluating patient-reported outcomes such as the PROMIS Physical Function Short Form 10a (PF10a) in rheumatoid arthritis (RA) have been performed in Caucasian and English-speaking populations. We assessed the measurement properties of the PF10a in a racially/ethnically diverse population with RA. We determined the effect of non-English language proficiency, insurance status and race/ethnicity, on the validity and responsiveness of the PF10a. METHODS: Data were abstracted from electronic health records for all RA patients seen in a university-based rheumatology clinic between 2013 and 2017...
August 12, 2018: Arthritis Care & Research
Catriona Hippman, Lynda G Balneaves
BACKGROUND: Depression is common, particularly among women of childbearing age, and can have far-reaching negative consequences if untreated. Efficacious treatments are available, but little is known about how women make depression treatment decisions during pregnancy. The purpose of this narrative review is to interpretively synthesize literature on women's decision making (DM) regarding antidepressant use during pregnancy. METHODS: The databases PubMed, CINAHL, and PsycINFO were searched between May 2015 and August 2017 for peer-reviewed, English-language papers using terms such as "depression," "pregnancy," and "DM...
August 12, 2018: Depression and Anxiety
Adam G Horwitz, Ewa K Czyz, Johnny Berona, Cheryl A King
OBJECTIVE: Rumination is often cited as a risk factor for suicide, yet few studies of rumination have utilized clinical samples, and no studies have examined its prospective association with suicide attempts. The purpose of this study was to examine concurrent and prospective associations of brooding and reflection (the two components of rumination) with suicide ideation and suicide attempts among a high-risk clinical sample. METHOD: Participants were 286 adolescents and young adults (77% Caucasian, 59% female) aged 13-25 seeking psychiatric emergency services...
August 11, 2018: Suicide & Life-threatening Behavior
Hermela Shimelis, Holly LaDuca, Chunling Hu, Steven N Hart, Jie Na, Abigail Thomas, Margaret Akinhanmi, Raymond M Moore, Hiltrud Brauch, Angela Cox, Diana M Eccles, Amanda Ewart-Toland, Peter A Fasching, Florentia Fostira, Judy Garber, Andrew K Godwin, Irene Konstantopoulou, Heli Nevanlinna, Priyanka Sharma, Drakoulis Yannoukakos, Song Yao, Bing-Jian Feng, Brigette Tippin Davis, Jenna Lilyquist, Tina Pesaran, David E Goldgar, Eric C Polley, Jill S Dolinsky, Fergus J Couch
Background: Germline genetic testing with hereditary cancer gene panels can identify women at increased risk of breast cancer. However, those at increased risk of triple-negative (estrogen receptor-negative, progesterone receptor-negative, human epidermal growth factor receptor-negative) breast cancer (TNBC) cannot be identified because predisposition genes for TNBC, other than BRCA1, have not been established. The aim of this study was to define the cancer panel genes associated with increased risk of TNBC...
August 7, 2018: Journal of the National Cancer Institute
Yun Liu, Brian Tomlinson, Jiyuan Guo, Mahnaz Asgharnejad, Lars Bauer, Erwin Surmann, Xiaojuan Guo, Jan-Peer Elshoff
PURPOSE: The pharmacokinetic (PK) profile of the rotigotine transdermal patch is well characterized in Caucasian patients with Parkinson's disease (PD) but not in Chinese subjects. This article reports the PK variables, safety, and tolerability of the rotigotine transdermal patch (2 mg/24 hours and 4 mg/24 hours cold-chain PR2.1.1 formulation) in healthy Chinese subjects (SP0913; NCT01675024). A second study (PD0011; NCT02070796) evaluated the relative bioavailability of cold-chain (PR2...
July 2018: Clinical Therapeutics
Jaśmina Arabska, Anna Łucka, Dominik Strzelecki, Adam Wysokiński
AIM: Neurotrophin-3 (NT-3) is a neurotrophic factor responsible for promoting development, survival and function of neurons. NT-3 may be involved in the etiopathology of schizophrenia and mood disorders. However it must be cleared up if changes of NT-3 level are associated with schizophrenia itself or are secondary to certain symptoms (e.g. negative or depressive). The aim of this study was to examine whether the presence of negative or depressive symptoms affects peripheral NT-3 concentration in patients with schizophrenia...
August 8, 2018: Neuroscience Letters
Charlotte C Kruijt, Gerard C de Wit, Arthur A Bergen, Ralph J Florijn, Nicoline E Schalij-Delfos, Maria M van Genderen
PURPOSE: To describe the phenotypic spectrum of a large cohort of albino patients, to investigate the relationship between the ocular abnormalities and the visual acuity, and to define diagnostic criteria for the Caucasian population. We also estimated the prevalence of albinism in the Netherlands. DESIGN: Retrospective cohort study. SUBJECTS: We investigated the phenotype of 522 albinism patients from the databases of Bartiméus (452 patients), Leiden University Medical Center (44 patients) and the Academic Medical Center Amsterdam (26 patients)...
August 8, 2018: Ophthalmology
Rafał Kocyłowski, Mariusz Grzesiak, Zuzanna Gaj, Wiktor Lorenc, Ewa Bakinowska, Danuta Barałkiewicz, Constantin Sylvius von Kaisenberg, Joanna Suliburska
The objective of this study was to determine the concentration and the reference ranges of essential and toxic elements in amniotic fluid (AF) and maternal serum (MS) at birth. This study was conducted among 175 healthy pregnant Caucasian European women aged 18-42. AF and maternal blood samples were collected during delivery. An inductively coupled plasma mass spectrometry (ICP-MS) technique was used to determine the levels of Mg, Co, Cu, Zn, Sr, Cd, Ba, Pb, U, Ca, Cr, Al, Mn, V, Fe, As, Se and Sb in AF and MS...
August 10, 2018: Biological Trace Element Research
P L Tenzel, Z F Williams, R A McCarthy, W W Hope
PURPOSE: Given the difficulty of durable repairs, there is continued interest in hernia prevention. One emerging prevention technique for parastomal hernias is prophylactic mesh placement, whereby mesh is inserted during the index procedure as hernia prophylaxis. We evaluated our experience using prophylactic mesh when creating an ileal conduit. METHODS: We retrospectively reviewed patients undergoing robotic cystectomy with ileal conduit from 6/2010 to 8/2017. Patient demographics and operative/perioperative outcomes were documented...
August 10, 2018: Hernia: the Journal of Hernias and Abdominal Wall Surgery
Lutz Joachimsen, Nikolai J Gross, Wolf A Lagrèze
Myopia is on the increase worldwide and will become a major challenge over the next decades in terms of secondary ophthalmologic complications. There are effective therapeutic options available to slow or prevent the progression of myopia. So far, it has not been investigated whether there are possible additive effects of these interventions. Further investigations - especially in Caucasian populations - are necessary to verify the study results available from Asia. There is limited data on how long further progression of myopia is preventable...
August 2018: Klinische Monatsblätter Für Augenheilkunde
Justine Orr, Charles N Bernstein, Lesley A Graff, Scott B Patten, James M Bolton, Jitender Sareen, James J Marriott, John D Fisk, Ruth Ann Marrie
BACKGROUND: Within the multiple sclerosis (MS) population, depression and anxiety are highly prevalent comorbidities that are associated with adverse outcomes such as diminished quality of life and disability progression. In the general population, many people who do not meet formal diagnostic criteria for depression or anxiety disorders still identify a need for mental health care. Limited data are available regarding the perceived need for mental health care among persons with MS. OBJECTIVE: We aimed to determine factors associated with a perceived need for mental health care in the MS population...
July 29, 2018: Multiple Sclerosis and related Disorders
Akinyemi Oni-Orisan, Sharon Cresci, Philip G Jones, Katherine N Theken, John A Spertus, Craig R Lee
Inhibition of soluble epoxide hydrolase (sEH, EPHX2) elicits potent cardiovascular protective effects in preclinical models of ischemic cardiovascular disease (CVD), and genetic polymorphisms in EPHX2 have been associated with developing ischemic CVD in humans. However, it remains unknown whether EPHX2 variants are associated with prognosis following an ischemic CVD event. We evaluated the association between EPHX2 p.Lys55Arg and p.Arg287Gln genotype with survival in 667 acute coronary syndrome (ACS) patients...
August 7, 2018: Prostaglandins & Other Lipid Mediators
Xiaoling Cai, Xueying Gao, Wenjia Yang, Linong Ji
BACKGROUND: As initial combination therapy of metformin and dipeptidyl peptidase-4 (DPP-4) inhibitor, the efficacy and safety for the use of high dose of metformin or low dose of metformin and the efficacy and safety for the combination use for Asian and Caucasian patients were not clear. METHODS: Double-blind randomized controlled trials comparing the efficacy of initial combination therapy of metformin and DPP-4 inhibitors with metformin monotherapy were included...
August 10, 2018: Diabetes Technology & Therapeutics
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