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Lina Maria Serna-Higuita, Simone L Harrison, Petra Buttner, Margaret Glasby, Beverly A Raasch, Angelika Iftner, Claus Garbe, Peter Martus, Thomas Iftner
Keratinocyte cancer (KC) is the most common malignancy in Caucasians. The incidence of KC has increased over the past 40 years. This case-control study investigated the environmental and host risk-factors responsible for development of KC in Australia's high-risk population. Cases were immune-competent adults from Townsville, Australia (19.3°S) who had a new basal cell carcinoma (BCC) or squamous cell carcinoma (SCC) histologically-confirmed during 2004 to 2009. Cases were age-matched (±5 years) to immuno-competent, community-based controls from Townsville with no prior history of KC...
December 13, 2018: Acta Dermato-venereologica
Taylor D'Amore, Brendan Boyce, Addisu Mesfin
Background: Chordomas are rare malignant tumors of the spinal column often afflicting the upper cervical spine and sacrum. There are few large single center series on chordomas due to its rarity. The purpose of this study is to report a single center's experience with the operative and non-operative management of chordomas. Methods: We evaluated our institution's pathology database from 1994 to 2016 to identify patients diagnosed with chordomas. Inclusion criteria were chordomas of the mobile spine and sacrum...
September 2018: Journal of Spine Surgery (Hong Kong)
Defeng Meng, Xiao Ding, Jiaojiao Lan, Fangliang Peng, Weiguo Zhu, Zeyu Cheng, Haoruo Jia, Hao Xu, Chenhui Shi, Lijuan Pang, Wei Shan Wang
Osteoporosis is a polygenic disorder and has been demonstrated to be associated with ~30 candidate genes, the majority of which have also been implicated in the regulation of bone mineral density (BMD). Vitamin D receptor (VDR) is the candidate gene that has been most extensively studied. Certain studies have reported that the VDR single nucleotide polymorphism ApaI is associated with the risk of osteoporosis in Caucasian and African women. However, this association has not yet been studied in postmenopausal Han Chinese women in the Xinjiang area...
December 2018: Biomedical Reports
Dong Sun, Jinghui Lu, Chunxiao Hu, Qiangbo Zhang, Xiangdong Wang, Zongli Zhang, Sanyuan Hu
Previous studies have demonstrated that microRNA (miR)-760 serves an important role in various cancer types. However, to the best of our knowledge, its role in hepatocellular carcinoma (HCC) has not been fully elucidated. The current study investigated the prognostic role of miR-760 in HCC by using the Kaplan-Meier plotter database. The current data indicated that low expression of miR-760 was associated with higher overall survival (OS) for all patients with HCC from both the RNA-seq [hazard ratio (HR)=2.04; 95% confidence interval (CI)=1...
December 2018: Oncology Letters
Martha-Spyridoula Katsarou, Aikaterini Karathanasopoulou, Angeliki Andrianopoulou, Vasileios Desiniotis, Efthymios Tzinis, Efthimios Dimitrakis, Maria Lagiou, Evangelia Charmandari, Michael Aschner, Aristeidis M Tsatsakis, George P Chrousos, Nikolaos Drakoulis
Genetic polymorphisms in β1 -, β2 - and β3 -adrenergic receptors (β-ARs) have been associated with chronic non-communicable disorders, such as cardiovascular diseases, asthma, chronic obstructive pulmonary disease (COPD) and obesity, as well as β-agonists and antagonists response and toxicity. The purpose of this study was to determine the frequency distribution of ADRB1 genetic variants Ser49Gly and Arg389Gly, ADRB2 variants Gly16Arg and Gln27Glu, ADRB3 variant Trp64Arg in a Southeastern European Caucasian (SEC) population sample and to establish a comparison with existing data from other human populations...
2018: Frontiers in Genetics
Shengli Dong, Matthias Blüher, Yanqing Zhang, Hongju Wu, Suresh K Alahari
BACKGROUND/OBJECTIVES: NISCH-STAB1 is a newly identified locus correlated to human waist-hip ratio (WHR), which is a risk indicator of developing obesity-associated diabetes. Our previous studies have shown that Nisch mutant male mice increased glucose tolerance in chow-fed conditions. Thus we hypothesized that Nisch mutant mice will have changes in insulin resistance, adipocytes, hepatic steatosis when mice are fed with high-fat diet (HFD). METHODS: Insulin resistance was assessed in Nisch mutant mice and WT mice fed with high-fat diet (60% by kCal) or chow diet...
December 13, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Yongbo Wang, Yi Sun, Juan Tang, Wei Zhou, Xiaoxue Liu, Yongyi Bi, Zhi-Jiang Zhang
PURPOSE: Increasing epidemiologic evidence suggests that diabetes mellitus (DM) may be associated with a decreased risk of glioma. This systematic review assessed whether DM was associated with glioma risk. METHODS: Electronic searches were performed in PubMed, Web of Science, EMBASE, and Cochrane Library databases up to August 30, 2018. A random-effects model was performed to calculate summary effect size with corresponding 95% confidence intervals (CIs). RESULTS: In total, 10 studies (eight case-control studies and two cohort studies) matched the inclusion criteria...
November 26, 2018: Annals of Epidemiology
Tara Nicole Downs
Alzheimer's disease is becoming more predominant in our aging population. Statin medications have been reported to contribute to cognitive impairment. Updated cholesterol treatment guidelines significantly increase the proportion of people eligible for treatment with statins. Therefore, uncommon adverse effects related to this medication class have the potential to impact health care by increasing cognitive impairment and/or contributing to statin treatment avoidance. CASE : An 83-year-old Caucasian male was seen in a cognitive evaluation clinic for noticeable memory decline...
December 1, 2018: Consultant Pharmacist: the Journal of the American Society of Consultant Pharmacists
Raoul Kanav Khanna, Rabih Hage, Alexandre Hage, Vanessa Polin, Thomas Sené, Catherine Vignal-Clermont
RATIONALE: The association between intracranial hypertension (ICH) and ulcerative colitis (UC) is rare. We report the unusual case of a male patient with UC and ICH in whom both conditions resolved with mesalazine therapy. PATIENT CONCERNS: A 48-year-old Caucasian man presented to our department in June 2016 for decreased vision, transient visual obscuration, pulsatile tinnitus and headaches of 7 months duration. Bilateral optic disc swelling was found at fundus examination...
December 2018: Medicine (Baltimore)
Xinwei Zou, Yi Zhang, Lin Zhang, Jiaxi Li, Chenjie Zhu, Qiuhong Cheng, Jinhua Zhou, Youguo Chen
BACKGROUND: Murine double minute 2 homolog (MDM2) plays an important role in the downregulation of P53 tumor suppressor gene. MDM2 inhibits P53 transcriptional activity and thereby results in accelerated tumor formation. Overexpression of MDM2 has been found in several cancer types including endometrial cancer. SNP309 is located in the promoter region of MDM2 and contributes to the overexpression of MDM2. The association between MDM2 SNP309 polymorphism and endometrial cancer risk has been investigated in several studies; however, the conclusion remains controversial...
December 2018: Medicine (Baltimore)
Ivana A Vaughn, Ellen L Terry, Emily J Bartley, Nancy Schaefer, Roger B Fillingim
Osteoarthritis (OA), a leading cause of disability and pain, affects 32.5 million Americans, producing tremendous economic burden. While some findings suggest that racial/ethnic minorities experience increased OA pain severity, other studies have shown conflicting results. This meta-analysis examined differences in clinical pain severity between African Americans and Non-Hispanic Whites with osteoarthritis. Articles were initially identified October 1-5, 2016, and updated May 30, 2018 using PubMed®, Web of ScienceTM , PsycINFO, and the Cochrane Library...
December 10, 2018: Journal of Pain: Official Journal of the American Pain Society
Lucija Tudor, Marcela Konjevod, Matea Nikolac Perkovic, Dubravka Svob Strac, Gordana Nedic Erjavec, Suzana Uzun, Oliver Kozumplik, Marina Sagud, Zrnka Kovacic Petrovic, Nela Pivac
Posttraumatic stress disorder (PTSD) is a trauma and stressor related disorder that may develop after exposure to an event that involved the actual or possible threat of death, violence or serious injury. Its molecular underpinning is still not clear. Brain-derived neurotrophic factor (BDNF) modulates neuronal processes such as the response to stress, but also weight control, energy and glucose homeostasis. Plasma BDNF levels and a functional BDNF Val66Met (rs6265) polymorphism were reported to be associated with PTSD, as well as with increased body mass index (BMI) and dyslipidaemia in healthy subjects and patients with cardio-metabolic diseases, but these results are controversial...
2018: Frontiers in Psychiatry
Gyorgy Petrovics, Douglas K Price, Hong Lou, Yongmei Chen, Lisa Garland, Sara Bass, Kristine Jones, Indu Kohaar, Amina Ali, Lakshmi Ravindranath, Denise Young, Jennifer Cullen, Tiffany H Dorsey, Isabell A Sesterhenn, Stephen A Brassell, Inger L Rosner, Doug Ross, William Dahut, Stefan Ambs, William Douglas Figg, Shiv Srivastava, Michael Dean
BACKGROUND: Germline mutations in BRCA2 have been linked to a higher risk of prostate cancer (PCa), and high frequency of BRCA1 and BRCA2 (BRCA1/2) gene alterations was recently reported in metastatic castration-resistant PCa specimens. Mutations in BRCA2 vary in racial and ethnic groups including African-American (AA) and Caucasian-American (CA) populations. METHODS: BRCA1 and BRCA2 genes were sequenced (Ion AmpliSeq targeted sequencing) in archived blood DNA specimens in 1240 PCa patients, including 30% AA patients, in three different cohorts: localized early stage (T2) PCa (N = 935); advanced PCa (50% T3-4) (N = 189); and metastatic PCa (N = 116)...
December 12, 2018: Prostate Cancer and Prostatic Diseases
Claudia Alejandra Pereda, María Betina Nishishinya, Emilio J A Roldan
BACKGROUND: Almeria is a region in southeast Spain with optimal sunlight levels, along with low pluvial and pollution rates. If exposure to sunlight is sufficient to maintain adequate levels of vitamin D (25OHD), this population should display high serum levels. OBJECTIVES: To describe 25OHD serum status in women from Almeria and evaluate the impact of long sunlight exposure along the seasons on 25OHD. METHODS: Cross-sectional study, performed in women consecutively recruited from an outpatient rheumatology clinic...
December 9, 2018: Endocrinología, Diabetes y Nutrición
Nzali V Campbell, David A Weitzenkamp, Ian L Campbell, Ronald F Schmidt, Chindo Hicks, Michael J Morgan, David C Irwin, John J Tentler
BACKGROUND: Large-scale "omics" datasets have not been leveraged and integrated with functional analyses to discover potential drivers of cardiomyopathy. This study addresses the knowledge gap. METHODS: We coupled RNA sequence (RNA-Seq) variant detection and transcriptome profiling with pathway analysis to model drug refractory dilated cardiomyopathy (drDCM) using the BaseSpace sequencing hub and Ingenuity Pathway Analysis. We used RNA-Seq case-control datasets (n = 6 cases, n = 4 controls), exome sequence familial DCM datasets (n = 3 Italians, n = 5 Italians, n = 5 Chinese), and controls from the HapMap project (n = 5 Caucasians, and n = 5 Asians) for disease modeling and putative mutation discovery...
December 12, 2018: BMC Medical Genomics
Denise Buchner, Lena Hieggelke, Heike Löser, Christiane Josephine Bruns, Alexander Quaas, Markus Philipp Hussein Ghadimi
BACKGROUND: Collision tumors are rare cases with two different tumor entities growing synchronously. While adenocarcinoma of the pancreas is the most common pancreatic tumor with an incidence of 10 per 100.000, retroperitoneal liposarcoma remains very rare. This is the first report of a collision tumor between these two tumor entities. CASE PRESENTATION: Demographic details: The tumor was diagnosed in a 64 male Caucasian patient. Besides atrial fibrillation, arterial hypertension and a hypothyroidism there is no relevant medical history especially no history of cancer...
December 12, 2018: BMC Cancer
Shelley Hershner, Rahul Kakkar, Frances Chung, Mandeep Singh, Jean Wong, Dennis Auckley
BACKGROUND: Patients with narcolepsy may be at increased perioperative risk due to the interactions among anesthesia, narcolepsy, and narcolepsy medications. This study sought to determine the perioperative experience of narcoleptic patients undergoing anesthesia or sedation, the frequency of perioperative counseling, and self-reported surgical complications. METHODS: A 22-question survey was developed by expert consensus and distributed by the Narcolepsy Network...
December 11, 2018: Anesthesia and Analgesia
Maximilian J Hochmair, Anna Buder, Sophia Schwab, Otto C Burghuber, Helmut Prosch, Wolfgang Hilbe, Agnieszka Cseh, Richard Fritz, Martin Filipits
BACKGROUND: Acquired epidermal growth factor receptor (EGFR) T790M mutation is the primary resistance mechanism to first-generation EGFR tyrosine kinase inhibitors (TKIs) used in advanced, EGFR mutation-positive non-small-cell lung cancer (NSCLC). Available data, predominantly in Asian patients, suggest that this mutation is also the major cause of resistance to the irreversible ErbB family blocker, afatinib. For EGFR T790M-positive patients who progress on EGFR TKI therapy, osimertinib is an effective treatment option...
December 12, 2018: Targeted Oncology
Alba Santos, Gilbert Greub, Sébastien Aeby, Dorothea Wunder, Giuseppe Pantaleo, Camillo Ribi
Background: SLE is an autoimmune condition affecting predominantly women. Little is known regarding Chlamydia trachomatis infection in women with SLE, which may drive autoimmunity and contribute to obstetrical and vascular complications. Methods: This single-centre, case-control study set primary endpoint in the comparative seropositivity rate to C. trachomatis major outer membrane protein (MOMP) and chlamydial heat-shock protein-60 (cHSP60) in age-matched subjects...
2018: Lupus Science & Medicine
Chiara Tani, Elena Elefante, Miguel Martin-Cascón, Meriem Belhocine, Cristina Lavilla Olleros, Roberta Vagelli, Chiara Stagnaro, Nathalie Costedoat-Chalumeau, Guillermo Ruiz-Irastorza, Marta Mosca
Objectives: To analyse the real-life practice on the use of Tacrolimus (TAC) in patients with systemic lupus erythematosus (SLE) from three European SLE referral centres. Methods: Adult patients with SLE regularly followed at three European referral centres were included. Demographics, cumulative organ involvement, treatment history, Systemic Lupus Disease Activity Index (SLEDAI), laboratory features and physician's judgement were collected at baseline and at 3-6-12 months after starting TAC...
2018: Lupus Science & Medicine
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