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https://www.readbyqxmd.com/read/28725242/focal-application-of-low-dose-rate-brachytherapy-for-prostate-cancer-a-pilot-study
#1
S Sara Mahdavi, Ingrid T Spadinger, Septimiu E Salcudean, Piotr Kozlowski, Silvia D Chang, Tony Ng, Julio Lobo, Guy Nir, Hamid Moradi, Michael Peacock, W James Morris
PURPOSE: To evaluate the feasibility and to report the early outcomes of focal treatment of prostate cancer using low-dose-rate brachytherapy (LDR-PB). MATERIAL AND METHODS: Seventeen patients were screened with multi-parametric magnetic resonance imaging (mpMRI), 14 of whom proceeded to receive trans-perineal template mapping biopsy (TTMB). Focal LDR-PB was performed on five eligible patients using dual air kerma strength treatment plans based on planning target volumes derived from cancer locations and determined by TTMB...
June 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28725000/trivalent-y-3-ionic-sensor-development-based-on-e-methyl-n-nitrobenzylidene-benzenesulfonohydrazide-mnbbsh-derivatives-modified-with-nafion-matrix
#2
Mohammad Musarraf Hussain, Mohammed M Rahman, Muhammad Nadeem Arshad, Abdullah M Asiri
(E)-Methyl-N'-nitrobenzylidene-benzenesulfonohydrazide (MNBBSH) compounds were synthesized using a condensation procedure from the derivatives of nitrobenzaldehyde and 4-Methyl-benzenesulfonylhydrazine, which crystallized in ethanol and methanol as well as characterized by FTIR, UV-Vis, (1)H-NMR, and (13)C-NMR. MNBBSH structure was confirmed using a single crystal X-ray diffraction technique and used for the detection of selective yttrium ion (Y(3+)) by I-V system. A thin layer of MNBBSH was deposited onto a glassy carbon electrode (GCE) with 5% nafion for the sensitive and selective Y(3+) sensor...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28688613/brachytherapy-boost-utilization-and-survival-in-unfavorable-risk-prostate-cancer
#3
Skyler B Johnson, Nataniel H Lester-Coll, Jacqueline R Kelly, Benjamin H Kann, James B Yu, Sameer K Nath
BACKGROUND: There are limited comparative survival data for prostate cancer (PCa) patients managed with a low-dose rate brachytherapy (LDR-B) boost and dose-escalated external-beam radiotherapy (DE-EBRT) alone. OBJECTIVE: To compare overall survival (OS) for men with unfavorable PCa between LDR-B and DE-EBRT groups. DESIGN, SETTING, AND PARTICIPANTS: Using the National Cancer Data Base, we identified men with unfavorable PCa treated between 2004 and 2012 with androgen suppression (AS) and either EBRT followed by LDR-B or DE-EBRT (75...
July 5, 2017: European Urology
https://www.readbyqxmd.com/read/28683103/combination-therapeutics-of-nilotinib-and-radiation-in-acute-lymphoblastic-leukemia-as-an-effective-method-against-drug-resistance
#4
Kamran Kaveh, Yutaka Takahashi, Michael A Farrar, Guy Storme, Marcucci Guido, Jamie Piepenburg, Jackson Penning, Jasmine Foo, Kevin Z Leder, Susanta K Hui
Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) is characterized by a very poor prognosis and a high likelihood of acquired chemo-resistance. Although tyrosine kinase inhibitor (TKI) therapy has improved clinical outcome, most ALL patients relapse following treatment with TKI due to the development of resistance. We developed an in vitro model of Nilotinib-resistant Ph+ leukemia cells to investigate whether low dose radiation (LDR) in combination with TKI therapy overcome chemo-resistance...
July 2017: PLoS Computational Biology
https://www.readbyqxmd.com/read/28670842/long-term-oncological-outcomes-and-toxicity-in-597-men-%C3%A2-60-years-of-age-at-time-of-low-dose-rate-brachytherapy-for-localised-prostate-cancer
#5
Stephen E M Langley, Ricardo Soares, Jennifer Uribe, Santiago Uribe-Lewis, Julian Money-Kyrle, Carla Perna, Sara Khaksar, Robert Laing
OBJECTIVES: To report oncological and functional outcomes of men treated with low dose rate (LDR) prostate brachytherapy who were 60 years old or younger at time of treatment. PATIENTS AND METHODS: Of 3,262 patients treated with LDR brachytherapy at our centre up to June 2016, we retrospectively identified 597 patients ≤60 years at treatment with at least three years post-implant follow-up and four PSA measurements of which one was the baseline. Overall disease-specific and relapse-free survival were analysed together with prospectively collected physician reported adverse events and patient reported symptom scores...
July 3, 2017: BJU International
https://www.readbyqxmd.com/read/28664931/the-evolution-of-brachytherapy-for-prostate-cancer
#6
REVIEW
Nicholas G Zaorsky, Brian J Davis, Paul L Nguyen, Timothy N Showalter, Peter J Hoskin, Yasuo Yoshioka, Gerard C Morton, Eric M Horwitz
Brachytherapy (BT), using low-dose-rate (LDR) permanent seed implantation or high-dose-rate (HDR) temporary source implantation, is an acceptable treatment option for select patients with prostate cancer of any risk group. The benefits of HDR-BT over LDR-BT include the ability to use the same source for other cancers, lower operator dependence, and - typically - fewer acute irritative symptoms. By contrast, the benefits of LDR-BT include more favourable scheduling logistics, lower initial capital equipment costs, no need for a shielded room, completion in a single implant, and more robust data from clinical trials...
June 30, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28640235/stereo-vision-based-high-dynamic-range-imaging-using-differently-exposed-image-pair
#7
Won-Jae Park, Seo-Won Ji, Seok-Jae Kang, Seung-Won Jung, Sung-Jea Ko
In this paper, a high dynamic range (HDR) imaging method based on the stereo vision system is presented. The proposed method uses differently exposed low dynamic range (LDR) images captured from a stereo camera. The stereo LDR images are first converted to initial stereo HDR images using the inverse camera response function estimated from the LDR images. However, due to the limited dynamic range of the stereo LDR camera, the radiance values in under/over-exposed regions of the initial main-view (MV) HDR image can be lost...
June 22, 2017: Sensors
https://www.readbyqxmd.com/read/28621527/dielectrophoretic-assembled-single-and-parallel-aligned-ag-nanowire-zno-branched-nanorod-heteronanowire-ultraviolet-photodetectors
#8
Zhi Yang, Minqiang Wang, Qiang Zhao, Hengwei Qiu, Junjie Li, Xiangming Li, Jinyou Shao
The branched hierarchical heteronanowires have been widely studied for optoelectronics application because of their unique electronic and photonic performances. Here, we successfully synthesized Ag nanowire-ZnO-branched nanorod heteronanowires based on an improved hydrothermal method. Then we fabricated single heteronanowire across a Au electrode pair with different gap widths and parallel-aligned heteronanowires on a Au interdigitated electrode with a dielectrophoresis method, indicating the flexibility and operability of the dielectrophoresis assembly method...
July 12, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28615058/long-term-prognostic-significance-of-rising-psa-levels-following-radiotherapy-for-localized-prostate-cancer-focus-on-overall-survival
#9
Carla Freiberger, Vanessa Berneking, Thomas-Alexander Vögeli, Ruth Kirschner-Hermanns, Michael J Eble, Michael Pinkawa
BACKGROUND: The aim of this study was to evaluate the long-term prognostic significance of rising PSA levels, particularly focussing on overall survival. METHODS: Two hundred ninety-five patients with localized prostate cancer were either treated with low-dose-rate (LDR) brachytherapy with I-125 seeds as monotherapy (n = 94; 145Gy), high-dose-rate (HDR) brachytherapy with Ir-192 as a boost to external beam RT (n = 66; 50.4Gy in 1.8Gy fractions EBRT + 18Gy in 9Gy fractions HDR) or EBRT alone (70...
June 14, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28582638/association-of-cd147-genetic-polymorphisms-with-carotid-atherosclerotic-plaques-in-a-han-chinese-population-with-cerebral-infarction
#10
Tongtian Ni, Min Chen, Kang Yang, Jianwei Shao, Yi Fu, Weijun Zhou
INTRODUCTION: Given the important role of CD147 in the development of atherosclerosis, we speculated that CD147 genetic polymorphisms might influence the formation of carotid atherosclerotic plaques. The study was to investigate the association between CD147 gene polymorphisms and susceptibility to carotid atherosclerotic plaques in individuals with cerebral infarction (CI). METHODS: Eight SNPs in the regulatory and coding regions of the CD147 gene were examined using polymerase chain reaction-ligase detection reaction (PCR-LDR) in DNA samples from 732 Chinese patients with CI, divided into a carotid plaque group (n=475) and a non-carotid plaque group (n=257)...
May 26, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28581398/ascende-rt-an-analysis-of-health-related-quality-of-life-for-a-randomized-trial-comparing-low-dose-rate-brachytherapy-boost-with-dose-escalated-external-beam-boost-for-high-and-intermediate-risk-prostate-cancer
#11
Sree Rodda, W James Morris, Jeremy Hamm, Graeme Duncan
PURPOSE: To report the patient-reported health-related quality of life (HR-QoL) outcomes for a multicenter randomized trial evaluating the safety and efficacy of 2 different techniques for dose escalation. METHODS AND MATERIALS: A total of 357 men with intermediate- and high-risk prostate cancer were stratified by risk group and randomized (1:1) to either a dose-escalated external beam (DE-EBRT) boost (n=177) or a low-dose-rate prostate brachytherapy (LDR-PB) boost (n=180) as part of combined modality therapy...
July 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28560334/extraordinary-linear-dynamic-range-in-laser-defined-functionalized-graphene-photodetectors
#12
Adolfo De Sanctis, Gareth F Jones, Dominique J Wehenkel, Francisco Bezares, Frank H L Koppens, Monica F Craciun, Saverio Russo
Graphene-based photodetectors have demonstrated mechanical flexibility, large operating bandwidth, and broadband spectral response. However, their linear dynamic range (LDR) is limited by graphene's intrinsic hot-carrier dynamics, which causes deviation from a linear photoresponse at low incident powers. At the same time, multiplication of hot carriers causes the photoactive region to be smeared over distances of a few micrometers, limiting the use of graphene in high-resolution applications. We present a novel method for engineering photoactive junctions in FeCl3-intercalated graphene using laser irradiation...
May 2017: Science Advances
https://www.readbyqxmd.com/read/28558232/transparent-carbon-ultramicroelectrode-arrays-for-the-electrochemical-detection-of-a-bacterial-warfare-toxin-pyocyanin
#13
Janine Elliott, Olja Simoska, Scott Karasik, Jason B Shear, Keith J Stevenson
Pyocyanin is a virulence factor produced as a secondary metabolite by the opportunistic human pathogen, Pseudomonas aeruginosa. Fast and direct detection of pyocyanin is of importance as it could provide important insights regarding P. aeruginosa's virulence mechanisms. Here, we present an electrochemical sensing platform of redox-active pyocyanin using transparent carbon ultramicroelectrode arrays (T-CUAs), which were made using a previously reported simple fabrication process ( Duay et al. Anal. Chem. 2015 , 87 , 10109 )...
June 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28515807/external-validation-of-the-procars-nomograms-and-comparison-of-existing-risk-stratification-tools-for-localized-prostate-cancer
#14
David Tiberi, George Rodrigues, Tom Pickles, Jim Morris, Juanita Crook, Andre-Guy Martin, Fabio Cury, Charles Catton, Himu Lukka, Andrew Warner, Daniel Taussky
INTRODUCTION: The purpose of this study was to perform a direct comparison of several existing risk-stratification tools for localized prostate cancer in terms of their ability to predict for biochemical failure-free survival (BFFS). Two large databases were used and an external validation of two recently developed nomograms on an independent cohort was also performed in this analysis. METHODS: Patients who were treated with external beam radiotherapy (EBRT) and/or brachytherapy for localized prostate cancer were selected from the multi-institutional Genitourinary Radiation Oncologists of Canada (GUROC) Prostate Cancer Risk Stratification (ProCaRS) database (n=7974) and the Centre Hospitalier de l'Université de Montréal (CHUM) validation database (n=2266)...
March 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28501161/fabrication-of-selective-chemical-sensor-with-ternary-zno-sno2-yb2o3-nanoparticles
#15
Mohammed M Rahman, M M Alam, Abdullah M Asiri, M A Islam
Construction of highly efficient toxic chemical sensors is the key approach for the determination of carcinogenic chemicals in the environment and ecosystem. We report here, an efficient acetone chemical sensor based on the analytical performances such as sensitivity, lower-detection limit, reproducibility, and good linearity. The proposed acetone-detecting electrode was introduced by the implementation of ZnO/SnO2/Yb2O3 nanoparticles (NPs) as a successful electron mediator with glassy carbon electrode (GCE) assembly...
August 1, 2017: Talanta
https://www.readbyqxmd.com/read/28496973/8-styryl-substituted-coralyne-derivatives-as-dna-binding-fluorescent-probes
#16
P M Pithan, D Decker, S I Druzhinin, H Ihmels, H Schönherr, Y Voß
Six new 8-styryl-substituted coralyne derivatives 4a-f were synthesized from coralyne (2) by a base catalysed Knoevenagel type reaction. It was shown by photometric and fluorimetric titrations of double stranded and quadruplex DNA to 4b-d as well as by fluorimetric DNA denaturation experiments that these ligands bind to DNA with different binding modes at varying ligand-DNA ratios (LDR). Specifically, the addition of DNA caused initially a hypochromic effect in absorbance and, at a particular LDR, the development of a new red shifted absorption band with a hyperchromic effect...
February 8, 2017: RSC Advances
https://www.readbyqxmd.com/read/28495442/validation-of-plastic-scintillation-detectors-for-applications-in-low-dose-rate-brachytherapy
#17
François Therriault-Proulx, Luc Beaulieu, Sam Beddar
PURPOSE: To develop a plastic scintillation detector (PSD) capable of accurately measuring dose around a low-dose-rate (LDR) iodine-125 ((125)I) radioactive seed as a first step toward in vivo dosimetry for prostate LDR brachytherapy. METHODS: Using a GEANT4 based Monte Carlo code, photon energy distribution at any position around a realistic (125)I source model was obtained. This energy distribution was convolved with the expected energy response from a plastic scintillator and dosimetry accuracy was evaluated...
May 8, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28488030/-125-i%C3%A2-brachytherapy-in-younger-prostate-cancer-patients-outcomes-in-low-and-intermediate-risk-disease
#18
Isabelle Kindts, Karin Stellamans, Ignace Billiet, Hans Pottel, Antoon Lambrecht
PURPOSE: To evaluate local recurrence in younger men treated with low-dose-rate (LDR) (125)I brachytherapy (BT) for localized prostate cancer. PATIENTS AND METHODS: A total of 192 patients (≤65-years-old) were treated with LDR (125)I-BT ± hormone therapy. Local failure was defined as any prostate-specific antigen (PSA) rise leading to salvage treatment or biochemical failure according to the Phoenix definition. A bounce was defined as a rise in the nadir of ≥0...
May 9, 2017: Strahlentherapie und Onkologie: Organ der Deutschen Röntgengesellschaft ... [et Al]
https://www.readbyqxmd.com/read/28469796/low-dose-radiation-modulates-human-mesenchymal-stem-cell-proliferation-through-regulating-cdk-and-rb
#19
Lei Yang, Ziling Liu, Chen Chen, Xiaofeng Cong, Zhi Li, Shasha Zhao, Meng Ren
Low-dose radiation (LDR) has been known to stimulate cell proliferation. The effect of LDR on human bone marrow mesenchymal stem cells (BMSCs), however, remains to be determined. The current study, therefore, aimed to investigate the effect of LDR on human BMSC proliferation and its mechanisms. To accomplish this, human BMSCs were isolated from ribs and cultured with or without exposition to LDR (75 mGy) for 24 h. Cell proliferation was assessed by MTT assay, the cytokines secreted by the BMSCs were quantified by ELISA, and the proteins associated with cell proliferation and cell cycle were evaluated by immunoblot analysis...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28464458/highly-sensitive-and-broadband-organic-photodetectors-with-fast-speed-gain-and-large-linear-dynamic-range-at-low-forward-bias
#20
Riming Nie, Xianyu Deng, Lei Feng, Guiguang Hu, Yangyang Wang, Gang Yu, Jianbin Xu
Photodetectors with high photoelectronic gain generally require a high negative working voltage and a very low environment temperature. They also exhibit low response speed and narrow linear dynamic range (LDR). Here, an organic photodiode is demonstrated, which shows a large amount of photon to electron multiplication at room temperature with highest external quantum efficiency (EQE) from ultraviolet (UV) to near-infrared region of 5.02 × 10(3) % (29.55 A W(-1) ) under a very low positive voltage of 1.0 V, accompanied with a fast response speed and a high LDR from 10(-7) to 10(1) mW cm(-2) ...
June 2017: Small
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