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https://www.readbyqxmd.com/read/29775393/proactive-strategy-for-long-term-biological-research-aimed-at-low-dose-radiation-risk-in-korea
#1
Ki Moon Seong, TaeWoo Kwon, Jina Park, BuHyun Youn, Hyuck-Jin Cha, Yonghwan Kim, Changjong Moon, Seung-Sook Lee, Young Woo Jin
PURPOSE: Since the 2011 Fukushima nuclear power plant accident, Korean radiation experts have agreed that reliable data on health risks of low-dose radiation (LDR) are needed to ease the anxiety of lay people. The intent of this study was to devise a sustainable biological program suited for the research environment in Korea and aimed at the health effects of radiation exposures <100 millisieverts (mSv). To address pressing public concerns over LDR risk, we investigated the current understanding of LDR effects by analyzing the previous reports of international authorities for radiation protection and research publications that appeared after the Chernobyl accident...
May 18, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29766324/a-general-lc-ms-ms-method-for-monitoring-potential-%C3%AE-lactam-contamination-in-drugs-and-drug-manufacturing-surfaces
#2
Chen Qiu, Hongbin Zhu, Connie Ruzicka, David Keire, Hongping Ye
Penicillins and some non-penicillin β-lactams may cause potentially life-threatening allergic reactions. Thus, possible cross contamination of β-lactams in food or drugs can put people at risk. Therefore, when there is a reasonable possibility that a non-penicillin product could be contaminated by penicillin, the drug products are tested for penicillin contamination. Here, a sensitive and rapid method for simultaneous determination of multiple β-lactam antibiotics using high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and validated...
May 15, 2018: AAPS Journal
https://www.readbyqxmd.com/read/29764032/-genes-polymorphism-of-bin1-and-apoe-in-patients-with-amnestic-mild-cognitive-impairment-from-enshi-tujia-area
#3
J Chen, Y Xia, C L Gao, R X Wang, Z N Lu
Objective: To investigate the polymorphism of BIN1 and ApoE genes in amnestic mild cognitive impairment (aMCI) patients in Tujia minority area of Enshi, Hubei. Methods: A total of 107 patients with aMCI (aMCI group) and 150 healthy people (healthy control group) during the same period were included between December 2016 and October 2017 in Affiliated Minda Hospital of Hubei University for Nationalities, who were all the Tujia nationality. Three single nucleotide polymorphic site of BIN1 gene rs744373, rs7561528, rs6733839, and two single nucleotide polymorphic site of ApoE gene rs429358, rs7412, and Genotyping and sub-genotyping of ApoE genes were tested using ligase detection reaction technique(LDR), and gene polymorphisms of BIN1 and ApoE were analyzed with Logistic regression analysis...
May 8, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29751910/selective-determination-of-caffeine-in-foods-with-3d-graphene-based-ultrasound-assisted-magnetic-solid-phase-extraction
#4
Afshin Rahimi, Mohammad Ali Zanjanchi, Sadjad Bakhtiari, Mohammad Dehsaraei
An efficient method was applied for extraction of caffeine in food samples. Three-dimensional graphene-Fe3 O4 (3D-G-Fe3 O4 ) nanoparticles was successfully synthesized and used as adsorbent in magnetic solid phase extraction (MSPE) step. The properties of synthesized adsorbent were characterized by fourier-transform infrared spectroscopy (FT-IR), scanning electron microscope (SEM), vibrating sample magnetometer (VSM), X-ray diffraction (XRD), Raman spectroscopy, Brunauer-Emmett-Teller (BET) and Barrett-Joyner-Halenda (BJH) methods...
October 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29748526/association-of-single-nucleotide-polymorphisms-of-cd44-gene-with-susceptibility-to-breast-cancer-in-chinese-women
#5
Xiao Lin, Xiaojing You, Xuezhen Cao, Shenghua Pan
BACKGROUND This study aimed to evaluate the association of CD44 gene single-nucleotide polymorphisms with susceptibility to breast cancer. MATERIAL AND METHODS This case-control study included 242 breast cancer patients and 252 normal people without disease. The single-nucleotide polymorphisms of the CD44 gene in the 2 groups were genotyped by PCR-LDR method. The OR and its 95% CI was calculated by chi-square test and logistic regression analysis. The construction of haplotypes and their interaction analysis with relevant factors were carried out by SHEsis and SNPStats online...
May 11, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29745023/interstitial-brachytherapy-for-pediatric-soft-tissue-sarcoma-evolving-practice-over-three-decades-and-long-term-outcomes
#6
Siddhartha Laskar, Avinash Pilar, Nehal Khanna, Ajay Puri, Ashish Gulia, Sajid Qureshi, Girish Chinnaswamy, Tushar Vora, Mukta Ramadwar
PURPOSE: Evaluate long-term clinical outcomes, adverse effects, and evolving practice of interstitial brachytherapy (BT) for pediatric soft tissue sarcomas (STS). METHODS: From September 1984 to December 2014, 105 children (median age 10 years) were included. There were 60 males and 45 females. The majority (74%) had primary lesions. Synovial sarcoma (22%) was the most frequent histology. Treatment included wide local excision and BT with or without external beam radiotherapy (EBRT)...
May 10, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29667307/reduction-of-seed-motion-using-a-bio-absorbable-polymer-coating-during-permanent-prostate-brachytherapy-using-a-mick-applicator-technique
#7
Gregory R Warrell, Yan Xing, Tarun K Podder, Bryan J Traughber, Rodney J Ellis
PURPOSE: The addition of a braided bio-absorbable vicryl coating to the surface of radioactive seeds used for low dose rate (LDR) prostate brachytherapy is intended to reduce the incidence of seed movement and migration. Here, we present a single-institution study of the frequency and severity of seed slippage (initial seed movement) of coated seeds in comparison with uncoated seeds. METHODS: Forty-seven patients received permanent prostate brachytherapy, with either coated (n = 26) or uncoated (n = 21) seeds...
April 17, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29619050/time-to-psa-rise-differentiates-the-psa-bounce-after-hdr-and-ldr-brachytherapy-of-prostate-cancer
#8
Wojciech Burchardt, Janusz Skowronek
Purpose: To investigate the differences in prostate-specific antigen (PSA) bounce (PB) after high-dose-rate (HDR-BT) or low-dose-rate (LDR-BT) brachytherapy alone in prostate cancer patients. Materials and methods: Ninety-four patients with localized prostate cancer (T1-T2cN0), age ranged 50-81 years, were treated with brachytherapy alone between 2008 and 2010. Patients were diagnosed with adenocarcinoma, Gleason score ≤ 7. The LDR-BT total dose was 144-145 Gy, in HDR-BT - 3 fractions of 10...
February 2018: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/29607601/ldr-brachytherapy-for-the-treatment-of-localised-prostate-cancer-in-men-with-a-high-risk-of-disease-relapse
#9
Robert Laing, Jennifer Uribe, Santiago Uribe-Lewis, Julian Money-Kyrle, Carla Perna, Stylianos Chintzoglou, Sara Khaksar, Stephen E M Langley
OBJECTIVES: To report clinical outcomes of Iodine-125 Low-Dose-Rate Prostate Brachytherapy (LDR-PB) as monotherapy or in combination with androgen deprivation therapy (ADT) and/or external beam radiotherapy (EBRT) in high-risk localised prostate cancer (PCa). PATIENTS AND METHODS: Analysis of clinical outcomes from a prospective cohort of patients treated with LDR-PB alone or combination treatment in a single institution. Men with a high risk of disease relapse were identified by the National Institute for Healthcare Excellence (NICE) criteria or by the National Comprehensive Cancer Network (NCCN) criteria...
April 1, 2018: BJU International
https://www.readbyqxmd.com/read/29604086/em-enhanced-us-based-seed-detection-for-prostate-brachytherapy
#10
Ehsan Dehghan, Shyam Bharat, Cynthia Kung, Antonio Bonillas, Luc Beaulieu, Jean Pouliot, Jochen Kruecker
PURPOSE: Intraoperative dosimetry in low-dose-rate (LDR) permanent prostate brachytherapy requires accurate localization of the implanted seeds with respect to the prostate anatomy. Transrectal Ultrasound (TRUS) imaging, which is the main imaging modality used during the procedure, is not sufficiently robust for accurate seed localization. We present a method for integration of electromagnetic (EM) track-ing into LDR prostate brachytherapy procedure by fusing it with TRUS imaging for seed localization...
March 31, 2018: Medical Physics
https://www.readbyqxmd.com/read/29599576/evaluation-of-bond-strength-and-load-deflection-rate-of-multi-stranded-fixed-retainer-wires-an-in-vitro-study
#11
Renu Sarah Samson, Eby Varghese, Eswara Uma, Pramod Redder Chandrappa
Background: Fixed orthodontic retainers must be well retained on the tooth surfaces, allow physiologic movement of teeth and exert minimal forces on the teeth to be retained. Previous studies analyzed the bond strength and amount of deflection caused due to the debonding force but not the magnitude of force needed for unit deformation. Aims: This study aims to evaluate and compare the bond strength and load deflection rate (LDR) of three different fixed retainer wires...
January 2018: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29597088/ldr-reverses-ddp-resistance-in-ovarian-cancer-cells-by-affecting-ercc-1-bcl-2-survivin-and-caspase-3-expressions
#12
Xingyan Ju, Hongsheng Yu, Donghai Liang, Tao Jiang, Yuanwei Liu, Ling Chen, Qing Dong, Xiaoran Liu
BACKGROUND: Ovarian cancer is the most frequent cause of death resulting from malignant gynecological tumors. After surgical intervention, cisplatin (DDP) is a major chemotherapy drug for ovarian cancer, but the ovarian cancer cells tend to develop DDP resistance in the clinical setting. Tumor cells are sensitive to low-dose radiation (LDR). However, how the LDR therapy improves the effects of chemotherapy drugs on ovarian cancer is not well understood. This study aimed to explore this issue...
March 26, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29577651/prostate-specific-antigen-nadir-within-12-months-as-an-early-surrogate-marker-of-biochemical-failure-and-distant-metastasis-after-low-dose-rate-brachytherapy-or-external-beam-radiotherapy-for-localized-prostate-cancer
#13
Shuichi Nishimura, Toshio Ohashi, Tetsuo Momma, Masanori Sakayori, Takahisa Eriguchi, Tomoki Tanaka, Shoji Yamashita, Takeo Kosaka, Mototsugu Oya, Naoyuki Shigematsu
Prostate-specific antigen nadir (nPSA) after radiotherapy for localized prostate cancer has been investigated as a predictor. However, nPSA usually requires several years, limiting its clinical utility. We investigated the significance of nPSA within 12 months (nPSA12) after low-dose-rate prostate brachytherapy (LDR-PB) or external beam radiotherapy (EBRT) on treatment outcomes. Between 2006 and 2014, 663 patients with prostate cancer were treated with LDR-PB or EBRT at two institutions. Four hundred and seventy-four men received LDR-PB and 189 men received EBRT, without androgen deprivation therapy...
March 25, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29560292/resection-cavity-contraction-effects-in-the-use-of-radioactive-sources-1-25-versus-cs-131-for-intra-operative-brain-implants
#14
Dae Y Han, Lijun Ma, Steve Braunstein, David Raleigh, Patricia K Sneed, Michael McDermott
Background and Objectives Intra-parenchymal brain surgical resection cavities usually contract in volume following low dose rate (LDR) brachytherapy implants. In this study, we systematically modeled and assessed dose variability resulting from such changes for I-125 versus Cs-131 radioactive sources. Methods Resection cavity contraction was modeled based on 95 consecutive patient cases, using surveillance magnetic resonance (MR) images. The model was derived for single point source geometry and then fully simulated in 3D where I-125 or Cs-131 seeds were placed on the surface of an ellipsoidal resection cavity...
January 16, 2018: Curēus
https://www.readbyqxmd.com/read/29557337/insights-into-the-performance-of-sd-bioline-malaria-ag-p-f-pan-rapid-diagnostic-test-and-plasmodium-falciparum-histidine-rich-protein-2-gene-variation-in-madagascar
#15
Nigani Willie, Rajeev K Mehlotra, Rosalind E Howes, Tovonahary A Rakotomanga, Stephanie Ramboarina, Arsène C Ratsimbasoa, Peter A Zimmerman
Plasmodium falciparum histidine-rich protein 2 (PfHRP2) forms the basis of many current malaria rapid diagnostic tests (RDTs). However, the parasites lacking part or all of the pfhrp2 gene do not express the PfHRP2 protein and are, therefore, not identifiable by PfHRP2-detecting RDTs. We evaluated the performance of the SD Bioline Malaria Ag P.f/Pan RDT together with pfhrp2 variation in Madagascar. Genomic DNA isolated from 260 patient blood samples were polymerase chain reaction (PCR)-amplified for the parasite 18S rRNA and pfhrp2 genes...
March 19, 2018: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29556586/the-civasheet-the-new-frontier-of-intraoperative-radiation-therapy-or-a-pricier-alternative-to-ldr-brachytherapy
#16
Danushka Seneviratne, Christopher McLaughlin, Dorin Todor, Brian Kaplan, Emma C Fields
No abstract text is available yet for this article.
January 2018: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29555027/integrating-plant-and-animal-biology-for-the-search-of-novel-dna-damage-biomarkers
#17
REVIEW
Zacharenia Nikitaki, Marcela Holá, Mattia Donà, Athanasia Pavlopoulou, Ioannis Michalopoulos, Karel J Angelis, Alexandros G Georgakilas, Anca Macovei, Alma Balestrazzi
Eukaryotic genome surveillance is dependent on the multiple, highly coordinated network functions of the DNA damage response (DDR). Highlighted conserved features of DDR in plants and animals represent a challenging opportunity to develop novel interdisciplinary investigations aimed at expanding the sets of DNA damage biomarkers currently available for radiation exposure monitoring (REM) in environmental and biomedical applications. In this review, common and divergent features of the most relevant DDR players in animals and plants are described, including the intriguing example of the plant and animal kingdom-specific master regulators SOG1 (suppressor of gamma response) and p53...
January 2018: Mutation Research
https://www.readbyqxmd.com/read/29554285/effects-of-various-radiation-doses-on-induced-t-helper-cell-differentiation-and-related-cytokine-secretion
#18
Hui Gao, Zhuo Dong, Xinkou Gong, Juancong Dong, Yuyu Zhang, Wei Wei, Rui Wang, Shunzi Jin
Exposure to ionizing radiation often induces T helper (Th) cell differentiation, resulting in an imbalance of Th1 and Th2 cellular subtypes, which can affect the efficacy of cancer radiotherapy. The aim of this study was to analyze differential expression of Th1, Th2 and Th3/Type 1 regulatory T cell (Tr1) subtype-related genes and cytokines in mouse thymocytes after high- and low-dose systemic radiation, using functional classification gene arrays and Elisa assays, and to explore the molecular mechanisms underlying radiation's immune effects and their relationship with Th1/Th2 immunity...
March 15, 2018: Journal of Radiation Research
https://www.readbyqxmd.com/read/29542269/comp-report-cpqr-technical-quality-control-guidelines-for-low-dose-rate-permanent-seed-brachytherapy
#19
Luc Beaulieu, Dee-Ann Radford, J Eduardo Villarreal-Barajas
The Canadian Organization of Medical Physicists (COMP), in close partnership with the Canadian Partnership for Quality Radiotherapy (CPQR) has developed a series of Technical Quality Control (TQC) guidelines for radiation treatment equipment. These guidelines outline the performance objectives that equipment should meet in order to ensure an acceptable level of radiation treatment quality. The TQC guidelines have been rigorously reviewed and field tested in a variety of Canadian radiation treatment facilities...
March 14, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29531508/gamma-low-dose-rate-ionizing-radiation-stimulates-adaptive-functional-and-molecular-response-in-human-aortic-endothelial-cells-in-a-threshold-dose-and-dose-rate-dependent-manner
#20
Juliana Vieira Dias, Celine Gloaguen, Dimitri Kereselidze, Line Manens, Karine Tack, Teni G Ebrahimian
A central question in radiation protection research is whether low-dose and low-dose-rate (LDR) exposures to ionizing radiation play a role in progression of cardiovascular disease. The response of endothelial cells to different LDR exposures may help estimate risk of cardiovascular disease by providing the biological mechanism involved. We investigated the effect of chronic LDR radiation on functional and molecular responses of human aorta endothelial cells (HAoECs). Human aorta endothelial cells were continuously irradiated at LDR (6 mGy/h) for 15 days and analyzed at time points when the cumulative dose reached 0...
January 2018: Dose-response: a Publication of International Hormesis Society
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