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Mohammed M Rahman, Mohammad Musarraf Hussain, Abdullah M Asiri
Iron oxide ornamented carbon nanotube nanocomposites (Fe3O4.CNT NCs) were prepared by a wet-chemical process in basic means. The optical, morphological, and structural characterizations of Fe3O4.CNT NCs were performed using FTIR, UV/Vis., FESEM, TEM; XEDS, XPS, and XRD respectively. Flat GCE had been fabricated with a thin-layer of NCs using a coating binding agent. It was performed for the chemical sensor development by a dependable I-V technique. Among all interfering analytes, 3-methoxyphenol (3-MP) was selective towards the fabricated sensor...
2017: PloS One
Abdullah A Gibriel, Ola Adel
Genetic variants have been reported to cause several genetic diseases. Various genotyping assays have been developed for diagnostic and screening purposes but with certain limitations in sensitivity, specificity, cost effectiveness and/or time savings. Since the discovery of ligase chain reaction (LCR) in the late nineties, it became one of the most favored platforms for detecting these variants and also for genotyping low abundant contaminants. Recent and powerful modifications with the integration of various detection strategies such as electrochemical and magnetic biosensors, nanoparticles (NPs), quantum dots, quartz crystal and leaky surface acoustic surface biosensors, DNAzyme, rolling circle amplification (RCA), strand displacement amplification (SDA), surface enhanced raman scattering (SERS), chemiluminescence and fluorescence resonance energy transfer have been introduced to both LCR and ligation based amplifications to enable high-throughput and inexpensive multiplex genotyping with improved robustness, simplicity, sensitivity and specificity...
July 2017: Mutation Research
Hua Huang, Si-Chao Huang, Dong-Jin Hua, Qing-Qing Sun, Han Cen, Xia-Fei Xin
Two pairwise genetic interactions (B cell lymphocyte kinase (BLK) rs13277113,B cell scaffold protein with ankyrin repeats 1 (BANK1) rs3733197and BLK rs13277113 membrane metalloendopeptidase like 1 (MMEL1)/ tumor necrosis factor receptor superfamily member 14 (TNFRSF14) rs3890745) have been demonstrated in determining susceptibility to rheumatoid arthritis (RA) without replication, thus this study was performed to examine whether abovementioned genetic polymorphisms were associated with RA and further tests were performed to see whether aforementioned genetic interactions existed in RA among Chinese population...
September 19, 2017: Autoimmunity
J Helou, S Torres, H B Musunuru, J Raphael, P Cheung, D Vesprini, H T Chung, L D'Alimonte, M Krahn, G Morton, A Loblaw
AIMS: To conduct a cost-utility analysis comparing stereotactic body radiotherapy (SBRT) with low dose rate brachytherapy (LDR-BT) for localised prostate cancer (PCa). MATERIALS AND METHODS: A decision-analytic Markov model was developed from the healthcare payer perspective to simulate the history of a 66-year-old man with low-risk PCa. The model followed patients yearly over their remaining lifetimes. Health states included 'recurrence-free', 'biochemical recurrence' (BR), 'metastatic' and 'death'...
September 12, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
Michelle I Echevarria, Arash O Naghavi, Yazan A Abuodeh, Kamran A Ahmed, Carlos Chevere, Daniel Fernandez, Kosj Yamoah
PURPOSE: In areas with limited health care, it is important to identify and implement effective treatment methods and to optimize available resources. We investigated the implementation of a low-dose-rate (LDR) brachytherapy program for the treatment of prostate cancer (PCa) in a low-resource setting such as Puerto Rico (PR), where PCa is the main cause of cancer-associated death. METHODS AND MATERIALS: After institutional approval, the medical records of patients with nonmetastatic PCa undergoing LDR brachytherapy from 2008 to 2013 were reviewed from PR...
October 1, 2017: International Journal of Radiation Oncology, Biology, Physics
Anne Graupner, Dag M Eide, Dag A Brede, Michele Ellender, Elisabeth Lindbo Hansen, Deborah H Oughton, Simon D Bouffler, Gunnar Brunborg, Ann Karin Olsen
Risk estimates for radiation-induced cancer in humans are based on epidemiological data largely drawn from the Japanese atomic bomb survivor studies, which received an acute high dose rate (HDR) ionising radiation. Limited knowledge exists about the effects of chronic low dose rate (LDR) exposure, particularly with respect to the application of the dose and dose rate effectiveness factor. As part of a study to investigate the development of colon cancer following chronic LDR vs. acute HDR radiation, this study presents the results of genotoxic effects in blood of exposed mice...
August 30, 2017: Environmental and Molecular Mutagenesis
Cameron M Callaghan, Lin Wang, Abhishek Alluri, Andrew Lauve, Cynthia Boyer, William Russell
PURPOSE: The purpose of this study was to determine the relationship between patient, disease, and treatment variables and biochemical failure-free survival (bFFS) following low-dose-rate prostate brachytherapy (LDR-BT). METHODS AND MATERIALS: Data from 624 consecutive patients who received LDR-BT for localized prostate cancer between 2002 and 2012 at a single institution were collected for various patient, disease, and treatment characteristics including a 4-8 week postimplant PSA (4-8wkPSA)...
August 24, 2017: Brachytherapy
Marco Picone, Martina Bergamin, Eugenia Delaney, Annamaria Volpi Ghirardini, Kresten Ole Kusk
The early-life stages of development of the calanoid copepod Acartia tonsa from egg to copepodite I is proposed as an endpoint for assessing sediment toxicity by exposing newly released eggs directly onto the sediment-water interface. A preliminary study of 5 sediment samples collected in the lagoon of Venice highlighted that the larval development rate (LDR) and the early-life stages (ELS) mortality endpoints with A. tonsa are more sensitive than the standard amphipod mortality test; moreover LDR resulted in a more reliable endpoint than ELS mortality, due to the interference of the sediment with the recovery of unhatched eggs and dead larvae...
August 24, 2017: Ecotoxicology and Environmental Safety
Nobumichi Tanaka, Isao Asakawa, Yasushi Nakai, Makito Miyake, Satoshi Anai, Tomomi Fujii, Masatoshi Hasegawa, Noboru Konishi, Kiyohide Fujimoto
BACKGROUND: To compare the PSA value at the last follow-up of patients who underwent prostate low-dose rate brachytherapy (LDR-BT) with that of patients who underwent intensity-modulated radiation therapy (IMRT). METHODS: A total of 610 prostate cancer patients (cT1c-3bN0M0) were enrolled, and 445 of them underwent LDR-BT, while 165 received IMRT (74-76 Gy). The median follow-up period of these two groups was 75 months (LDR-BT) and 78 months (IMRT), respectively...
August 25, 2017: BMC Cancer
Rong-Hua Song, Qian Li, Wen Wang, Qiu-Ming Yao, Xiao-Qing Shao, Jin-An Zhang
As there are no previous studies on the interleukin-22 (IL-22) variants in autoimmune thyroid disease (AITD), the present study aimed to explore the association between polymorphisms of IL-22 and the predisposition to AITD. The study had 975 AITD patients, including 639 Graves' disease (GD) and 336 Hashimoto's thyroiditis (HT) individuals and 851 healthy cohorts. Ligase detection reaction (LDR) and direct sequencing method were used for genotyping the IL-22 gene polymorphisms at rs2046068, rs2227478, rs2227485, rs11611206, and rs1179251...
2017: International Journal of Endocrinology
Marisa A Kollmeier, Sean McBride, Amandeep Taggar, Erik Anderson, Mary Lin, Xin Pei, Shi Weiji, Laszlo Voros, Gilad Cohen, Yoshiya Yamada, Michael J Zelefsky
BACKGROUND: Salvage brachytherapy is a treatment option for patients with locally recurrent prostate cancer after primary radiation therapy. We reviewed our experience using low-dose-rate (LDR) or high-dose-rate (HDR) brachytherapy to compare the outcome and toxicity profiles of each approach in the salvage brachytherapy setting. METHODS AND MATERIALS: Ninety-eight patients with biopsy-proven locally recurrent prostate cancer who underwent salvage brachytherapy (LDR = 37; HDR = 61) following an initial course of definitive radiotherapy between 4/2003 and 4/2015 were retrospectively reviewed...
August 21, 2017: Brachytherapy
Paulraj Kanmani, Leonardo Albarracin, Hisakazu Kobayashi, Hikaru Iida, Ryoya Komatsu, A K M Humayun Kober, Wakako Ikeda-Ohtsubo, Yoshihito Suda, Hisashi Aso, Seiya Makino, Hiroshi Kano, Tadao Saito, Julio Villena, Haruki Kitazawa
Previous studies demonstrated that the extracellular polysaccharides (EPSs) produced by Lactobacillus delbrueckii OLL1073R-1 (LDR-1) improve antiviral immunity, especially in the systemic and respiratory compartments. However, it was not studied before whether those EPSs are able to beneficially modulate intestinal antiviral immunity. In addition, LDR-1-host interaction has been evaluated mainly with immune cells while its interaction with intestinal epithelial cells (IECs) was not addressed before. In this work, we investigated the capacity of EPSs from LDR-1 to modulate the response of porcine IECs (PIE cells) to the stimulation with the Toll-like receptor (TLR)-3 agonist poly(I:C) and the role of TLR2, TLR4, and TLR negative regulators in the immunoregulatory effect...
August 8, 2017: Molecular Immunology
Frank Zijlstra, Marinus A Moerland, Jochem R N van der Voort van Zyp, Juus L Noteboom, Max A Viergever, Peter R Seevinck
PURPOSE: An MR-only postimplant dosimetry workflow for low dose rate (LDR) brachytherapy could reduce patient burden, improve accuracy, and improve cost efficiency. However, localization of brachytherapy seeds on MRI scans remains a major challenge for this type of workflow. In this study, we propose and validate an MR-only seed localization method, and identify remaining challenges. METHODS AND MATERIALS: The localization method was based on template matching of simulations of complex-valued imaging artifacts around metal brachytherapy seeds...
August 4, 2017: Medical Physics
Qu Zhou, ChangXiang Hong, Yao Yao, Ahmed Mohamed Ibrahim, Lingna Xu, Rajesh Kumar, Sumaia Mohamed Talballa, S H Kim, Ahmad Umar
Highly sensitive acetone chemical sensor was fabricated using ZnO nanoballs modified silver electrode. A low temperature, facile, template-free hydrothermal technique was adopted to synthesize the ZnO nanoballs with an average diameter of 80 ± 10 nm. The XRD and UV-Vis. studies confirmed the excellent crystallinity and optical properties of the synthesized ZnO nanoballs. The electrochemical sensing performance of the ZnO nanoballs modified AgE towards the detection of acetone was executed by simple current-voltage (I-V) characteristics...
July 14, 2017: Materials
Ahmed A Ibrahim, Preeti Tiwari, M S Al-Assiri, A E Al-Salami, Ahmad Umar, Rajesh Kumar, S H Kim, Z A Ansari, S Baskoutas
Herein, we report a facile synthesis, characterization, and electrochemical sensing application of ZnO nanopeanuts synthesized by a simple aqueous solution process and characterized by various techniques in order to confirm the compositional, morphological, structural, crystalline phase, and optical properties of the synthesized material. The detailed characterizations revealed that the synthesized material possesses a peanut-shaped morphology, dense growth, and a wurtzite hexagonal phase along with good crystal and optical properties...
July 13, 2017: Materials
Min Seok Kim, Gil Ju Lee, Hyun Myung Kim, Young Min Song
Curved image sensors, which are a key component in bio-inspired imaging systems, have been widely studied because they can improve an imaging system in various aspects such as low optical aberrations, small-form, and simple optics configuration. Many methods and materials to realize a curvilinear imager have been proposed to address the drawbacks of conventional imaging/optical systems. However, there have been few theoretical studies in terms of electronics on the use of a lateral photodetector as a flexible image sensor...
August 2, 2017: Sensors
Xiao Wen Mao, Nina C Nishiyama, Mary Campbell-Beachler, Peter Gifford, Kristine E Haynes, Daila S Gridley, Michael J Pecaut
The purpose of this study was to determine whether nicotinamide adenine dinucleotide phosphate (NADPH) oxidase-derived stress can account for unloading- and radiation-induced endothelial damage and neurovascular remodeling in a mouse model. Wild-type (WT, Nox2(+/+)) C57BL/6 mice or Nox2(-/-) (B6.129S6-CYBBM) knockout (KO) mice were placed into one of the following groups: age-matched control; hindlimb unloading (HLU); low-dose/low-dose-rate radiation (LDR); or HLU with LDR simultaneously for 21 days. The mice were then sacrificed one month later...
August 1, 2017: Radiation Research
Sqn Ldr Jimish Desai
Common peroneal nerve palsy in maxillofacial surgery setting is an uncommon and rarely reported complication. A patient who developed common peroneal nerve palsy following reduction and fixation of pan facial fractures under general anesthesia is presented. The patient developed common peroneal nerve palsy on the second postoperative day. He recovered with conservative treatment after 3 months. The authors consider that the nerve palsy was a result of compression of common peroneal nerve related to patient positioning in the perioperative period...
January 2017: National Journal of Maxillofacial Surgery
Bo Jiang, Yong Zhang, Chang She, Jiaju Zhao, Kailong Zhou, Zhicheng Zuo, Xiaozhong Zhou, Peiji Wang, Qirong Dong
INTRODUCTION: It is well known that moderate to high doses of ionizing radiation have a toxic effect on the organism. However, there are few experimental studies on the mechanisms of LDR ionizing radiation on nerve regeneration after peripheral nerve injury. METHODS: We established the rats' peripheral nerve injury model via repaired Peripheral nerve injury nerve, vascular endothelial growth factor a and Growth associated protein-43 were detected from different treatment groups...
July 22, 2017: Environmental Toxicology and Pharmacology
Bing Liu, Haibin Ni, Di Zhang, Delong Wang, Degang Fu, Hongyuan Chen, Zhongze Gu, Xiangwei Zhao
Detection of proteins in a wide concentration range from fg mL(-1) to sub mg mL(-1) is a challenge in the high throughput analysis of precision medicine. Herein, we proposed a biosensor consisting of core-shell surface-enhanced Raman scattering (SERS) nanotags as labels and photonic crystal beads (PCBs) as carriers for ultrasensitive detection of proteins. In practice, Raman dyes (RDs) were embedded in the interface of gold core and silver shell in the bimetal nanoparticles to form SERS nanotags. It was found that the sensitivity was significantly improved due to the enhanced Raman signal by the coupling of the core-shell structure and linear dynamic range (LDR) was extended owing to the high surface to volume ratio of PCBs as well...
July 28, 2017: ACS Sensors
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