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https://www.readbyqxmd.com/read/28815696/a-novel-method-for-sub-arc-vmat-dose-delivery-verification-based-on-portal-dosimetry-with-an-epid
#1
Ruud A M Cools, Maarten L P Dirkx, Ben J M Heijmen
PURPOSE: EPID-based sub-arc verification of VMAT dose delivery requires synchronization, i.e., establishing the start- and stop-MU of acquired electronic portal images (EPIs). To realize this, published synchronization methods propose the use of logging features of the linac or dedicated hardware solutions. In this study, we developed a novel, software-based synchronization method that only uses information inherently available in the acquired images. METHOD: EPIs are continuously acquired during pre-treatment VMAT delivery and converted into Portal Dose Images (PDIs)...
August 16, 2017: Medical Physics
https://www.readbyqxmd.com/read/28810881/comparison-of-photon-volumetric-modulated-arc-therapy-intensity-modulated-proton-therapy-and-intensity-modulated-carbon-ion-therapy-for-delivery-of-hypo-fractionated-thoracic-radiotherapy
#2
Alexander Chi, Lien-Chun Lin, Sijin Wen, Haijuan Yan, Wen-Chien Hsi
PURPOSE: The aim of the present study was to compare the dose distribution generated from photon volumetric modulated arc therapy (VMAT), intensity modulated proton therapy (IMPT), and intensity modulated carbon ion therapy (IMCIT) in the delivery of hypo-fractionated thoracic radiotherapy. METHODS AND MATERIALS: Ten selected patients who underwent thoracic particle therapy between 2015 and 2016 were re-planned to receive a relative biological effectiveness (RBE) weighted dose of 60 Gy (i...
August 15, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28806990/dvh-and-ntcp-based-dosimetric-comparison-of-different-longitudinal-margins-for-vmat-imrt-of-esophageal-cancer
#3
S Münch, M Oechsner, S E Combs, D Habermehl
PURPOSE: To cover the microscopic tumor spread in squamous cell carcinoma of the esophagus (SCC), longitudinal margins of 3-4 cm are used for radiotherapy (RT) protocols. However, smaller margins of 2-3 cm might be reasonable when advanced diagnostic imaging is integrated into target volume delineation. Purpose of this study was to compare the dose distribution and deposition to the organs at risk (OAR) for different longitudinal margins using a DVH- and NTCP-based approach. METHODS: Ten patients with SCC of the middle or lower third were retrospectively selected...
August 15, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28805047/outcomes-of-post-prostatectomy-radiotherapy-at-a-regional-cancer-centre
#4
Luke Nicholls, Amber Winter, Ashley Harwood, Ashley Plank, Preeti Bagga, Winnie Wong, Eric Khoo
INTRODUCTION: To investigate the efficacy and toxicity of radiation therapy (RT) after radical prostatectomy (RP) for prostate cancer at Radiation Oncology Centres, Toowoomba. METHODS: The electronic medical records of 130 consecutive patients with histologically proven prostate adenocarcinoma who underwent post-prostatectomy RT between January 2008 and December 2014 were analysed. Primary endpoint was Biochemical Recurrence (BCR) after RT. BCR was defined by PSA > 0...
August 14, 2017: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/28794640/volumetric-modulated-arc-therapy-for-treatment-of-solid-tumors-current-insights
#5
REVIEW
Gabriella Macchia, Francesco Deodato, Savino Cilla, Silvia Cammelli, Alessandra Guido, Martina Ferioli, Giambattista Siepe, Vincenzo Valentini, Alessio Giuseppe Morganti, Gabriella Ferrandina
AIM: This article discusses the current use of volumetric modulated arc therapy (VMAT) techniques in clinical practice and reviews the available data from clinical outcome studies in different clinical settings. An overview of available literature about clinical outcomes with VMAT stereotactic/radiosurgical treatment is also reported. MATERIALS AND METHODS: All published manuscripts reporting the use of VMAT in a clinical setting from 2009 to November 2016 were identified...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28777469/a-method-for-a-priori-estimation-of-best-feasible-dvh-for-organs-at-risk-validation-for-head-and-neck-vmat-planning
#6
Saeed Ahmed, Benjamin Nelms, Dawn Gintz, Jimmy Caudell, Geoffrey Zhang, Eduardo G Moros, Vladimir Feygelman
PURPOSE: Despite improvements in optimization and automation algorithms, the quality of radiation treatment plans still varies dramatically. A tool that allows a priori estimation of the best possible sparing (Feasibility DVH, or FDVH) of an organ at risk (OAR) in high-energy photon planning may help reduce plan quality variability by deriving patient-specific OAR goals prior to optimization. Such a tool may be useful for 1) meaningfully evaluating patient-specific plan quality and 2) supplying best theoretically achievable DVH goals, thus pushing the solution towards automatic Pareto-optimality...
August 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/28777468/technical-note-a-novel-quality-assurance-test-to-identify-gantry-angle-inaccuracies-in-respiratory-gated-vmat-treatments
#7
Emily Hubley, Michael Briscoe, Nicolas Ploquin, Greg Pierce
PURPOSE: During respiratory-gated volumetric modulated arc therapy (VMAT), the radiation beam is turned off each time the target exits the gating window. At the same time, the gantry slows, stops, and rewinds before the beam is turned back on. A quality assurance (QA) test was developed to detect inaccuracies in the gantry angle position between beam-off and beam-on events during respiratory-gated VMAT. METHODS: Strips of Gafchromic(™) EBT3 film were taped to the surface of a Capthan(®) 504 phantom mounted at isocentre...
August 4, 2017: Medical Physics
https://www.readbyqxmd.com/read/28771941/dosimetric-and-radiobiological-comparison-for-quality-assurance-of-imrt-and-vmat-plans
#8
Nava Raj Paudel, Ganesh Narayanasamy, Eun Young Han, Jose Penagaricano, Panayiotis Mavroidis, Xin Zhang, Anil Pyakuryal, Dongwook Kim, Xiaoying Liang, Steven Morrill
INTRODUCTION: The gamma analysis used for quality assurance of a complex radiotherapy plan examines the dosimetric equivalence between planned and measured dose distributions within some tolerance. This study explores whether the dosimetric difference is correlated with any radiobiological difference between delivered and planned dose. METHODS: VMAT or IMRT plans optimized for 14 cancer patients were calculated and delivered to a QA device. Measured dose was compared against planned dose using 2-D gamma analysis...
August 3, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28761392/assessment-of-performance-indicators-of-a-radiotherapy-department-using-an-electronic-medical-record-system
#9
Yasir A Bahadur, Camelia Constantinescu, Ammar Y Bahadur, Ruba Y Bahadur
AIM: To retrospectively assess the performance indicators of our radiotherapy department and their temporal trends, using a commercially available electronic-medical-record (EMR) system. BACKGROUND: A recent trend in healthcare quality is to define and evaluate performance indicators of the service provided. MATERIALS AND METHODS: Patient and external-beam-radiotherapy-treatments data were retrieved using the Mosaiq EMR system from 1-January-2012 till 31-December-2015...
September 2017: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/28760506/a-comparison-of-treatment-plan-quality-between-tri-co-60-intensity-modulated-radiation-therapy-and-volumetric-modulated-arc-therapy-for-cervical-cancer
#10
Jong Min Park, So-Yeon Park, Jung-In Kim, Hyun-Cheol Kang, Chang Heon Choi
PURPOSE: To investigate the plan quality of tri-Co-60 intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) for cervical cancer. METHODS: A total of 20 patients who received postoperative radiotherapy for cervical cancer were selected. For each patient, a tri-Co-60 IMRT plan for which the target volume was the planning target volume (PTV) generated by adding 1mm isotropic margins from the clinical target volume (CTV) and a VMAT plan for which the target volume was the PTV generated by adding 7mm and 10mm margins from the CTV were generated...
July 28, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28755441/plan-quality-and-delivery-time-comparisons-between-volumetric-modulated-arc-therapy-and-intensity-modulated-radiation-therapy-for-scalp-angiosarcoma-a-planning-study
#11
Yudai Kai, Ryo Toya, Tetsuo Saito, Akiko Kuraoka, Yoshinobu Shimohigashi, Yuji Nakaguchi, Masato Maruyama, Ryuji Murakami, Yasuyuki Yamashita, Natsuo Oya
INTRODUCTION: Due to its spherical surface, scalp angiosarcoma requires careful consideration for radiation therapy planning and dose delivery. Herein, we investigated whether volumetric modulated arc therapy (VMAT) is superior to intensity modulated radiation therapy (IMRT) in terms of the plan quality and delivery time. METHODS: Three different coplanar treatment plans were created for four patients, comprising a two-arc VMAT plan as well as 5-field and 9-field IMRT plans with 6 MV beams...
July 29, 2017: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/28754289/dosimetric-benefits-of-automation-in-the-treatment-of-lower-thoracic-esophageal-cancer-is-manual-planning-still-an-alternative-option
#12
Xiadong Li, Lu Wang, Jiahao Wang, Xu Han, Bing Xia, Shixiu Wu, Weigang Hu
This study aimed to design automated volumetric-modulated arc therapy (VMAT) plans in Pinnacle auto-planning and compare it with manual plans for patients with lower thoracic esophageal cancer (EC). Thirty patients with lower thoracic EC were randomly selected for replanning VMAT plans using auto-planning in Pinnacle treatment planning system (TPS) version 9.10. Historical plans of these patients were then compared. Dose-volume histogram (DVH) statistics, dose uniformity, and dose homogeneity were analyzed to evaluate treatment plans...
July 25, 2017: Medical Dosimetry: Official Journal of the American Association of Medical Dosimetrists
https://www.readbyqxmd.com/read/28749618/radiation-induced-second-cancer-risk-from-external-beam-photon-radiotherapy-for-head-and-neck-cancer-impact-on-in-field-and-out-of-field-organs
#13
Vasanthan Sakthivel, Ganesh Kadirampatti Mani, Sunil Mani, Raghavendiran Boopathy
The purpose of this paper is to provide data on development of second primary cancers within or adjacent to tissue irradiated in the treatment of primary head and neck cancers using different techniques and modalities. Materials and methods: We selected five patients with HandN tumors located in base of the tongue for risk assessment. In order to examine the impact of choices of various planning techniques, numbers of beams and beam energy used in treatment plans - 7 and 9 field Intensity modulated radiotherapy (IMRT) plans using 6MV and 10 MV beam energies and a 6MV Volumetric modulated arc therapy (VMAT) plans were planned...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28749172/no-differences-in-radiological-changes-after-3d-conformal-vs-vmat-based-stereotactic-radiotherapy-for-early-stage-non-small-cell-lung-cancer
#14
Serena Badellino, Jacopo Di Muzio, Giulia Schivazappa, Alessia Guarneri, Riccardo Ragona, Sara Bartoncini, Elisabetta Trino, Andrea Riccardo Filippi, Paolo Fonio, Umberto Ricardi
OBJECTIVES: To compare patterns of acute and late radiological lung injury following either 3D or image-guided VMAT stereotactic radiotherapy for stage I Non-Small-Cell Lung Cancer (NSCLC). METHODS: We included 148 patients from a prospective mono-institutional SBRT series (time interval 2004-2014), treated with prescription BED10 Gy (at 80%) in the range 100-120 Gy. The first 95 patients (2004-2010) were planned with 3D-CRT, with a stereotactic body frame. The second cohort (2010-2014) included 53 patients, planned with volumetric IMRT on a smaller PTV generated from a patient's specific ITV, with a frameless approach through cone-beam CT guidance...
July 27, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28742396/valbenazine-for-tardive-dyskinesia
#15
Oliver Freudenreich, Gary Remington
Tardive dyskinesia (TD) remains a clinical concern for any patient who receives an antipsychotic. While the overall risk of developing TD is lower with newer antipsychotics compared to older agents, a significant number of patients who require long-term treatment will develop TD. Recently, valbenazine (brand name Ingrezza) became the first drug to be approved by the FDA specifically for the treatment of TD. In this New Drug Review, we summarize the basic pharmacology and clinical trial results for valbenazine...
2017: Clinical Schizophrenia & related Psychoses
https://www.readbyqxmd.com/read/28740930/functional-image-guided-radiation-therapy-planning-in-volumetric-modulated-arc-therapy-for-patients-with-malignant-pleural-mesothelioma
#16
Yoshiko Doi, Tomoki Kimura, Takeo Nakashima, Yuki Takeuchi, Ippei Takahashi, Ikuno Nishibuchi, Yuji Murakami, Yasushi Nagata
PURPOSE: To investigate the incorporation of functional lung image-derived low-attenuation area (LAA) based on 4-dimensional computed tomography (4D-CT) in volumetric modulated arc therapy (VMAT) planning for patients with malignant pleural mesothelioma (MPM) after extrapleural pneumonectomy. METHODS AND MATERIALS: Twelve patients with MPM after extrapleural pneumonectomy were included. The primarily affected side was the right in 6 patients and the left in 6 patients...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28731267/heuristic-knowledge-based-planning-for-single-isocenter-stereotactic-radiosurgery-to-multiple-brain-metastases
#17
Benjamin P Ziemer, Parag Sanghvi, Jona Hattangadi-Gluth, Kevin L Moore
PURPOSE: Single-isocenter, volumetric modulated arc therapy (VMAT) stereotactic radiosurgery (SRS) for multiple brain metastases (multi-mets) can deliver highly conformal dose distributions and reduce overall patient treatment time compared to other techniques. However, treatment planning for multi-met cases is highly complex due to variability in numbers and sizes of brain metastases, as well as their relative proximity to organs-at-risk (OARs). The purpose of this study was to automate the VMAT planning of multi-met cases through a knowledge-based planning (KBP) approach that adapts single target SRS dose predictions to multiple target predictions...
July 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28727285/adapting-vmat-plans-optimized-for-an-hd120-mlc-for-delivery-with-a-millennium-mlc
#18
Samuel B French, Stephen Bhagroo, Daryl P Nazareth, Matthew B Podgorsak
Linac downtime invariably impacts delivery of patients' scheduled treatments. Transferring a patient's treatment to an available linac is a common practice. Transferring a Volumetric Modulated Arc Therapy (VMAT) plan from a linac equipped with a standard-definition MLC to one equipped with a higher definition MLC is practical and routine in clinics with multiple MLC-equipped linacs. However, the reverse transfer presents a challenge because the high-definition MLC aperture shapes must be adapted for delivery with the lower definition device...
July 20, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28714067/evaluation-of-plastic-scintillator-detector-for-small-field-stereotactic-patient-specific-quality-assurance
#19
Yujiao Qin, Stephen J Gardner, Joshua Kim, Yimei Huang, Ning Wen, Anthony Doemer, Indrin J Chetty
PURPOSE: To evaluate the performance of a commercial plastic scintillator detector (PSD) for small-field stereotactic patient-specific quality assurance (QA) measurements using flattening-filter-free beam. METHODS: A total of ten spherical targets (volume range: [0.03cc-2cc]) were planned with two techniques: (1) Dynamic Conformal Arc (DCA-10 plans), and (2) Volumetric Modulated Arc Therapy (VMAT-10 plans). All plans were generated using Varian Eclipse treatment planning system, and AcurosXB v...
July 17, 2017: Medical Physics
https://www.readbyqxmd.com/read/28712715/split-vmat-technique-to-control-the-expiratory-breath-hold-time-in-liver-stereotactic-body-radiation-therapy
#20
Yen Hwa Lin, Shuichi Ozawa, Hideharu Miura, Katsunori Yogo, Takeo Nakashima, Kentaro Miki, Shintaro Tsuda, Yusuke Ochi, Daisuke Kawahara, Tomoki Kimura, Akito Saito, Yasushi Nagata
PURPOSE: In this study, we demonstrate the feasibility of using split-arcs in volumetric modulated arc therapy (VMAT), tailored for expiratory breath-hold in stereotactic body radiation therapy (SBRT) for liver tumors. We compare it with three-dimensional conformal radiation therapy (3D-CRT) and continuous-VMAT, for ten randomly selected hepatocellular carcinoma cases. METHODS: Four coplanar and four non-coplanar beams were used for the 3D-CRT plans. A pair of partial arcs, chosen using a back-and-forth rotating motion, were used for the continuous-VMAT plans...
July 13, 2017: Physica Medica: PM
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