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JOURNAL ARTICLE
Xiaoqi Shao, Ling Yao, Jiao Fu, Mengmeng He, Pei Zhang
This study aims to investigate the differential expression of insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) in the peritoneal dialysate among patients with different durations of peritoneal dialysis and its association with the angiogenic marker vascular* endothelial growth factor (VEGF), the fibronectin (FN), and various clinical indicators. A cohort of 122 peritoneal dialysis patients was categorized into short-term (≤1 year, n = 33), mid-term (>1 and ≤5 years, n = 55), and long-term (>5 years, n = 34) groups based on dialysis duration...
April 2024: Clinical and Translational Science
#22
Maude Rancourt, Asher Frydman, Mohammed Tarabzoni, Vijay Gupta, Maged Elrayes, Satoru Fujii, Aashish Goela, Michael W A Chu
No abstract text is available yet for this article.
March 2024: CJC open
#23
JOURNAL ARTICLE
Alberto Lanfranco, Sahar Rakhshan, Diego Alberti, Polyssena Renzi, Ayda Zarechian, Nicoletta Protti, Saverio Altieri, Simonetta Geninatti Crich, Annamaria Deagostino
Mesothelioma is a malignant neoplasm of mesothelial cells caused by exposure to asbestos. The average survival time after diagnosis is usually nine/twelve months. A multi-therapeutic approach is therefore required to treat and prevent recurrence. Boronated derivatives containing a carborane cage, a sulfamido group and an ureido functionality (CA-USF) have been designed, synthesised and tested, in order to couple Boron Neutron Capture Therapy (BNCT) and the inhibition of Carbonic Anhydrases (CAs), which are overexpressed in many tumours...
March 26, 2024: European Journal of Medicinal Chemistry
#24
REVIEW
Hiroki Fujimoto, Masato Yoshihara, Raymond Rodgers, Shohei Iyoshi, Kazumasa Mogi, Emiri Miyamoto, Sae Hayakawa, Maia Hayashi, Satoshi Nomura, Kazuhisa Kitami, Kaname Uno, Mai Sugiyama, Yoshihiro Koya, Yoshihiko Yamakita, Akihiro Nawa, Atsushi Enomoto, Carmela Ricciardelli, Hiroaki Kajiyama
Epithelial ovarian cancer (EOC) is often diagnosed in advanced stage with peritoneal dissemination. Recent studies indicate that aberrant accumulation of collagen fibers in tumor stroma has a variety of effects on tumor progression. We refer to remodeled fibrous stroma with altered expression of collagen molecules, increased stiffness, and highly oriented collagen fibers as tumor-associated fibrosis (TAF). TAF contributes to EOC cell invasion and metastasis in the intraperitoneal cavity. However, an understanding of molecular events involved is only just beginning to emerge...
March 28, 2024: Cancer Metastasis Reviews
#25
JOURNAL ARTICLE
Barış Sarıçoban, Murat Kuru, Sıddıka Fındık, İbrahim Kılınç, Tamer Altınok
BACKGROUND: The aim of this study was to investigate the antifibrinolytic and anti-inflammatory effects of hesperidin, tenoxicam and enoxaparin on intrapleural adhesions in an experimental rat model. METHODS: A total of 52 healthy adult male Wistar Albino rats from the same colony were randomly divided into six groups as sham (Group 1), surgical control (Group 2), low-dose hesperidin (Group 3), high-dose hesperidin (Group 4), tenoxicam (Group 5), and enoxaparin (Group 6)...
January 2024: Türk Göğüs Kalp Damar Cerrahisi Dergisi
#26
REVIEW
Jayati Mallick, Beenu Thakral, Qing Wei, L Jeffrey Medeiros
Mesothelial/monocytic incidental cardiac excrescence (MICE) is a rare benign lesion composed of monocytes and mesothelial cells that is most often encountered during cardiothoracic surgery. We describe a case in a 71-year-old man with known aortic valve stenosis who presented with gradual onset dyspnea over a few weeks, made worse with minimal exertion. A transesophageal echocardiogram revealed severe aortic stenosis and mild pericardial effusion. The patient underwent aortic valve replacement, coronary artery bypass, and amputation of the left atrial appendage...
March 20, 2024: Annals of Diagnostic Pathology
#27
JOURNAL ARTICLE
Terri E Jones, Daniel L Geisler, Swikrity Upadhyay Baskota, N Paul Ohori, Jacqueline Cuda, Samer N Khader
INTRODUCTION: The diagnosis of mesothelioma has historically been challenging, especially on serous fluid cytology (SFC). Distinguishing between reactive and neoplastic mesothelial cells can be difficult on cytomorphology alone. However, additional ancillary tests, such as BRCA1 associated protein-1 immunohistochemistry and fluorescence in situ hybridization for cyclin-dependent kinase inhibitor 2A deletion, can provide a sensitive and highly specific method of proving malignancy. MATERIALS AND METHODS: SFC specimens diagnosed as mesothelioma, suspicious for mesothelioma (SM), and atypical mesothelial cells (AMCs) since 2012 were identified by querying the laboratory information system...
March 2, 2024: Journal of the American Society of Cytopathology
#28
JOURNAL ARTICLE
James Stevenson, David S Ettinger, Douglas E Wood, Dara L Aisner, Wallace Akerley, Jessica R Bauman, Ankit Bharat, Debora S Bruno, Joe Y Chang, Lucian R Chirieac, Malcolm DeCamp, Aakash Desai, Thomas J Dilling, Jonathan Dowell, Gregory A Durm, Marina C Garassino, Scott Gettinger, Travis E Grotz, Matthew A Gubens, Rudy P Lackner, Michael Lanuti, Jules Lin, Billy W Loo, Christine M Lovly, Fabien Maldonado, Erminia Massarelli, Daniel Morgensztern, Trey C Mullikin, Thomas Ng, Gregory A Otterson, Dawn Owen, Sandip P Patel, Tejas Patil, Patricio M Polanco, Gregory J Riely, Jonathan Riess, Theresa A Shapiro, Aditi P Singh, Alda Tam, Tawee Tanvetyanon, Jane Yanagawa, Stephen C Yang, Edwin Yau, Kristina Gregory, Lisa Hang
Mesothelioma is a rare cancer that originates from the mesothelial surfaces of the pleura and other sites, and is estimated to occur in approximately 3,500 people in the United States annually. Pleural mesothelioma is the most common type and represents approximately 85% of these cases. The NCCN Guidelines for Mesothelioma: Pleural provide recommendations for the diagnosis, evaluation, treatment, and follow-up for patients with pleural mesothelioma. These NCCN Guidelines Insights highlight significant updates to the NCCN Guidelines for Mesothelioma: Pleural, including revised guidance on disease classification and systemic therapy options...
March 2024: Journal of the National Comprehensive Cancer Network: JNCCN
#29
JOURNAL ARTICLE
Mohamad Hammoud, Carl Ammoury, Charbel Iskandar, Eliane Aoun, Reem Eid, Edouard Sayad
Parapneumonic pleural effusions are common in patients with pneumonia. When colonized by pathogenic bacteria or other microorganisms, these effusions can progress to empyema. Additionally, empyema formation may result in extension of the infection into the infradiaphragmatic region, further complicating the clinical scenario. Many subphrenic collections are found to be mesothelial cysts, which are congenital in origin. However, data regarding the potential association between mesothelial diaphragmatic cysts and parapneumonic effusions are limited...
March 2024: Journal of International Medical Research
#30
Haneen Al-Maghrabi, Jaudah Al-Maghrabi
Adenomatoid tumor (AT) is a benign growth that originates from mesothelial cells. Typically, it encompasses the uterus, fallopian tubes, and paratesticular area. One-third of all AT is in paratesticular area, and it accounts for 60% of all benign paratesticular tumors. ATs have been seldom reported as a case report in adrenal gland, liver, pleura, and mediastinal cavity. To date, English literature has only documented 46 instances of adrenal AT. We present the occurrence of a new clinically unexpected case of adrenal AT in a 37-year-old male patient...
March 2024: Journal of Surgical Case Reports
#31
JOURNAL ARTICLE
Shuai-Shuai Shi, Yi-Qiang Zhang, Lu-Qi Zhang, Yun-Feng Li, Xiao-Shuang Zhou, Rong-Shan Li
Sirtuin 6 (SIRT6) can inhibit the fibrosis of many organs. However, the relationship between SIRT6 and peritoneal fibrosis (PF) in peritoneal dialysis (PD) remains unclear. We collected 110 PD patients with a duration of PD for more than 3 months and studied the influence of PD duration and history of peritonitis on SIRT6 levels in PD effluents (PDEs). We also analyzed the relationship between SIRT6 levels in PDEs and transforming growth factor beta 1 (TGF-β1), IL-6, PD duration, peritoneal function, PD ultrafiltration (UF), and glucose exposure...
March 14, 2024: International Urology and Nephrology
#32
JOURNAL ARTICLE
Flavia Trionfetti, Claudia Montaldo, Ivan Caiello, Giulio Bontempi, Michela Terri, Marta Tiberi, Vanessa Marchant, Alessandro Domenici, Paolo Menè, Marco Cordani, Clemens Zwergel, Giusi Prencipe, Marta Ruiz-Ortega, Sergio Valente, Antonello Mai, Marco Tripodi, Raffaele Strippoli
Infectious peritonitis is a leading cause of peritoneal functional impairment and a primary factor for therapy discontinuation in peritoneal dialysis (PD) patients. Although bacterial infections are a common cause of peritonitis episodes, emerging evidence suggests a role for viral pathogens. Toll-like receptors (TLRs) specifically recognize conserved pathogen-associated molecular patterns (PAMPs) from bacteria, viruses, and fungi, thereby orchestrating the ensuing inflammatory/immune responses. Among TLRs, TLR3 recognizes viral dsRNA and triggers antiviral response cascades upon activation...
2024: Frontiers in Cellular and Infection Microbiology
#33
JOURNAL ARTICLE
Junichi Nakamata, Hiroyuki Morimoto, Ryoko Baba, Keiji Kokubu, Tetsu Miyamoto
Peritoneal dialysis (PD) fluid, which contains a high concentration of glucose, is involved in peritoneal damage after long-term use. The mechanisms through which glucose induces damage to the mesothelium have not been clearly elucidated. Although, endoplasmic reticulum (ER) stress response is associated with several diseases, the involvement of ER stress in peritoneal damage has not yet been demonstrated. Primary-cultured rat peritoneal mesothelial cells (RPMCs) and rat PD model were used to investigate the influence of glucose on the peritoneum...
February 29, 2024: Acta Histochemica et Cytochemica
#34
JOURNAL ARTICLE
Ming Zhao, Hualei Gan, Shan Zhong, Qiuyan Xia, Yanfeng Bai, Jiayun Xu, Xiaodong Teng, Jian Wang
Soft tissue neoplasms harboring fusions between EWSR1 or FUS with genes encoding CREB transcription factors family (ATF1, CREB1, and CREM) are an emerging heterogeneous group of mesenchymal tumors that differ significantly in morphology, immunophenotypes, and behavior. Recently, EWSR1/FUS::CREB fusions have been recognized to define a group of aggressive neoplasms of epithelioid morphology with multiple growth patterns and a striking predilection for mesothelial-lined cavities. These neoplasms presenting as a primary neoplasm of intra-abdominal visceral organs is rare, which could elicit a wide range of differential diagnoses due to their diverse morphologies and immunohistochemical profiles...
March 7, 2024: Modern Pathology
#35
Jyotsna Naresh Bharti
INTRODUCTION: Mesothelioma is an insidious neoplasm that develops from mesothelial cells. About 80% of mesotheliomas originate in the pleural cavity. Other sites where it has been reported are the peritoneal cavity, tunica vaginalis, and the pericardium. CASE PRESENTATION: A 45-year-old female complained of abdominal distention and pain for three months. There was a significant weight loss of approximately 15 kg in the past three months, and there was no family history of any malignancy, tuberculosis, substance abuse, or asbestosis exposure...
March 7, 2024: Current medical imaging
#36
JOURNAL ARTICLE
Yazgı Köy, Fikret Direniloğlu
OBJECTIVE: We aimed to analyze the clinical presentation, imaging, histopathology, and surgical management of pediatric intraabdominal cysts, which are relatively common but diverse lesions that pose diagnostic challenges. MATERIALS AND METHODS: We conducted a retrospective analysis of pediatric intraabdominal cysts from 2010 to 2021 in a single tertiary center. We collected data on demographics, symptoms, radiological findings, surgical approaches, and histopathological diagnoses and compared them with the current literature...
March 2024: Turkish archives of pediatrics
#37
Jaafar A Hamdan, Akbar Khan, Annalee Mora, Amrita Randhawa, Maria Castano
This is a case of a 37-year-old female patient with past medical history of mitral valve prolapse and benign mesothelial pericardial cyst status post laparoscopic resection who presented to the emergency department with a chief complaint of right-sided sharp non-radiating chest pain due to recurrent case of benign mesothelial pericardial cyst. Though this is not a common pathology, it does overlap with common cardiovascular symptoms/conditions; not limited to but including chest pain, dyspnea, palpitations, pericardial effusions, infections and arrhythmias...
February 2024: Curēus
#38
JOURNAL ARTICLE
Qiong Song, Pengbo Wang, Huan Wang, Meijing Pan, Xiujuan Li, Zhuan'e Yao, Wei Wang, Guangbo Tang, Sen Zhou
BACKGROUND: Peritoneal fibrosis is the prevailing complication induced by prolonged exposure to high glucose in patients undergoing peritoneal dialysis. METHODS: To elucidate the molecular mechanisms underlying this process, we conducted an integrated analysis of the transcriptome and chromatin accessibility profiles of human peritoneal mesothelial cells (HMrSV5) during high-glucose treatment. RESULTS: Our study identified 2775 differentially expressed genes (DEGs) related to high glucose-triggered pathological changes, including 1164 upregulated and 1611 downregulated genes...
March 5, 2024: Journal of Translational Medicine
#39
JOURNAL ARTICLE
Haojun Hua, Yanlin Deng, Jing Zhang, Xiang Zhou, Tianfu Zhang, Bee Luan Khoo
This study introduces AIEgen-Deep, an innovative classification program combining AIEgen fluorescent dyes, deep learning algorithms, and the Segment Anything Model (SAM) for accurate cancer cell identification. Our approach significantly reduces manual annotation efforts by 80%-90%. AIEgen-Deep demonstrates remarkable accuracy in recognizing cancer cell morphology, achieving a 75.9% accuracy rate across 26,693 images of eight different cell types. In binary classifications of healthy versus cancerous cells, it shows enhanced performance with an accuracy of 88...
February 7, 2024: Biosensors & Bioelectronics
#40
JOURNAL ARTICLE
Sreypich Say, Mika Suzuki, Yoshihide Hashimoto, Tsuyoshi Kimura, Akio Kishida
In post-adhesion surgery, there is a clinical need for anti-adhesion membranes specifically designed for the liver, given the limited efficacy of current commercial products. To address this demand, we present a membrane suitable for liver surgery applications, fabricated through the modification of decellularized porcine pericardium with 20 KDa 8-arm PEGNHS. We also developed an optimized modification procedure to produce a high-performance anti-adhesion barrier. The modified membrane significantly inhibited fibroblast cell adherence while maintaining minimal levels of inflammation...
February 29, 2024: Biomedical Materials
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