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Jinlin Liu, Xiaocheng Luo, Wenjian Wang, Sujie Zheng, Huijun Lin, Juping Zeng, Mao Wu
To systemically analyze megakaryocytes in pleural and peritoneal fluids and their clinical significance. We retrospectively examined 10,846 pleural, peritoneal, and pericardial fluid samples obtained from 3 hospitals over a 20-year period. Megakaryocytes were observed in the pleural fluid samples from 7 patients and peritoneal fluid samples from 2 patients, and the incidence was 0.83%. The clinical diagnoses of these 9 patients included myeloproliferative disorders, trauma, and tumors. The serous effusions in all 9 patients were bloody, and the megakaryocytes could be associated with trauma, bone marrow pollution, extramedullary hematopoiesis, or cancer...
August 2018: Medicine (Baltimore)
Sindhu G, Shyni G L, Chithra K Pushpan, Bala Nambisan, Helen A
Rheumatoid arthritis is a chronic inflammatory joint disease characterized by synovial proliferation and tissue destruction. Pro-inflammatory cytokines like interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α) play a key role in the disease process and elevate energy expenditure, which further increases the joint pain and stiffness. The present study was undertaken to explore the anti-arthritic potential of fenugreek mucilage in adjuvant induced arthritic rats. In the present study, paw volume was measured on the 7th , 14th and 21st day...
August 11, 2018: Prostaglandins & Other Lipid Mediators
Nkechiyere G Nwani, Livia E Sima, Wilberto Nieves-Neira, Daniela Matei
Cancer⁻stroma interactions play a key role in cancer progression and response to standard chemotherapy. Here, we provide a summary of the mechanisms by which the major cellular components of the ovarian cancer (OC) tumor microenvironment (TME) including cancer-associated fibroblasts (CAFs), myeloid, immune, endothelial, and mesothelial cells potentiate cancer progression. High-grade serous ovarian cancer (HGSOC) is characterized by a pro-inflammatory and angiogenic signature. This profile is correlated with clinical outcomes and can be a target for therapy...
August 10, 2018: Cancers
Daisuke Tamura, Daichi Maeda, Sultan Ahmad Halimi, Masato Okimura, Yukitsugu Kudo-Asabe, Satoru Ito, Naoki Sato, Junji Shibahara, Hiroshi Nanjo, Yukihiro Terada, Akiteru Goto
AIMS: Uterine adenomatoid tumour (AT) is a benign proliferation of cells showing mesothelial differentiation within the myometrium that usually presents as a single nodule. Rare diffuse uterine ATs have been reported, often in patients undergoing immunosuppressive therapy. Herein, we aimed to elucidate the general association between the incidence of uterine AT and iatrogenic immunosuppression by cohort analysis. METHODS AND RESULTS: We analysed 611 consecutive hysterectomy specimens to determine the incidence of AT and its correlation with the immunosuppressive status...
August 11, 2018: Histopathology
Stephen D Bird
No abstract text is available yet for this article.
August 9, 2018: Cell Calcium
Shinsuke Aida, Junko Aida, Miho Naoi, Mai Kato, Yukio Tsuura, Ichiro Natsume, Kaiyo Takubo
We estimated the telomere lengths of neoplastic and non-neoplastic mesothelial cells and examined their correlation with asbestos exposure and the expression of markers of mesothelial malignancy. Cell blocks of pleural effusion obtained from 35 cases of non-neoplastic disease (NN), 12 cases of malignant mesothelioma (MM) and 12 cases of carcinomatous effusion due to lung adenocarcinoma (LA) were examined. Fifteen of the 35 NN cases had pleural plaques (NNpp+) suggestive of asbestos exposure, and the other 20 cases had no pleural plaques (NNpp-)...
August 10, 2018: Pathology International
Karen M Watters, Preety Bajwa, Hilary A Kenny
Ovarian cancer progression involves multifaceted and variable tumor microenvironments (TMEs), from the in situ carcinoma in the fallopian tube or ovary to dissemination into the peritoneal cavity as single cells or spheroids and attachment to the mesothelial-lined surfaces of the omentum, bowel, and abdominal wall. The TME comprises the tumor vasculature and lymphatics (including endothelial cells and pericytes), in addition to mesothelial cells, fibroblasts, immune cells, adipocytes and extracellular matrix (ECM) proteins...
August 9, 2018: Cancers
Jun Xiao, Yong Hu, Kai-Ying Tang, Tahsin Tarik Torsha, Yu Xu, Zhi-Han Li, Xiang-Zhao Li, Zhan-Jun Shi
PURPOSE: Synovial cyst of knee cruciate ligament (SCKCL) is a rare condition but can cause severe knee pain. The understanding of its etiology is relatively poor. This current study aimed to elucidate the pathogenesis of SCKCL based on a series of histo- and cytopathological examination. METHODS: Ten SCKCL patients who underwent arthroscopy were enrolled, among five patients claimed past knee injury. Hematoxylin & eosin staining was conducted to the cyst wall tissue sections and Papanicolaou staining to the cyst fluid smear...
August 8, 2018: International Orthopaedics
Stefano Serra, Runjan Chetty
The p16 gene belongs to INK4 family of genes and is made up of four members: p16 INK4A , p15 INK4B , p18 INK4C and p19 INK4D , all of which share biological properties, namely, inhibition of cell growth and tumour suppression. After p53 , p16 is the second most common tumour suppressor gene. It has been regarded as the familial melanoma gene. Immunohistochemistry for p16 has a well-defined role in distinct pathological scenarios. It is used to distinguish desmoplastic melanoma from reactive fibrous proliferation, with former showing strong nuclear positivity...
August 3, 2018: Journal of Clinical Pathology
Klemen Pečnik, Vesna Todorović, Maša Bošnjak, Maja Čemažar, Igor Kononenko, Gregor Serša, Janez Plavec
Machine learning models in metabolomics, despite their great prediction accuracy, are still not widely adopted due to lack of efficient explanation of their predictions. In this study we propose using the general explanation method to explain machine learning model's predictions in order to gain detailed insights into metabolic differences between biological systems. The method was tested on a dataset of 1H NMR spectra acquired on normal lung and mesothelial cell lines and their tumor counterparts. Initially, the random forests and artificial neural network models were applied to the dataset and achieved excellent prediction accuracy...
August 1, 2018: Chembiochem: a European Journal of Chemical Biology
Akemi Shishido, Seiji Mori, Yuhki Yokoyama, Yoshinosuke Hamada, Kazumasa Minami, Yamin Qian, Jiaqi Wang, Haruka Hirose, Xin Wu, Naomasa Kawaguchi, Sachiko Nagumo, Nariaki Matsuura, Hirofumi Yamamoto
Ovarian cancer is characterized by widespread peritoneal dissemination with ascites. Spheroids observed in the ascites of ovarian cancer patients are a mixture of cancer cells and mesothelial cells. In the present study, we evaluated whether mesothelial cells exfoliated from the peritoneum facilitate tumor spheroid formation and give rise to cancer stem‑like properties in ovarian cancer cells. Spheroids from the CAOV3 and A2780 ovarian cancer cell lines grew much larger in co‑culture with mesothelial cells than in monoculture under 3D conditions...
October 2018: Oncology Reports
Pengpeng Yan, Huanna Tang, Xiaoying Chen, Shuiyu Ji, Wei Jin, Jiaming Zhang, Jia Shen, Hao Deng, Xiang Zhao, Quanquan Shen, Hongfeng Huang
Peritoneal fibrosis is a severe complication arising from long-term peritoneal dialysis (PD). Tamoxifen has been clinically proven effective in a series of fibrotic diseases, such as PD-associated encapsulating peritoneal sclerosis (EPS), but the mechanisms underlying Tamoxifen's protective effects have yet to be defined. In this study, C57BL/6 mice received intraperitoneal injections of either saline, 4.25% high glucose peritoneal dialysis fluid (PDF) or PDF plus Tamoxifen each day for 30 days. Tamoxifen attenuated thickening of the peritoneum, and reversed PDF induced peritoneal expression of E-cadherin, Vimentin, matrix metalloproteinase 9 (MMP9), Snail and β-catenin...
July 30, 2018: Bioscience Reports
Adam P Sage, Victor D Martinez, Brenda C Minatel, Michelle E Pewarchuk, Erin A Marshall, Gavin M MacAulay, Roland Hubaux, Dustin D Pearson, Aaron A Goodarzi, Graham Dellaire, Wan L Lam
Malignant mesothelioma is an aggressive and lethal asbestos-related disease. Diagnosis of malignant mesothelioma is particularly challenging and is further complicated by the lack of disease subtype-specific markers. As a result, it is especially difficult to distinguish malignant mesothelioma from benign reactive mesothelial proliferations or reactive fibrosis. Additionally, mesothelioma diagnoses can be confounded by other anatomically related tumors that can invade the pleural or peritoneal cavities, collectively resulting in delayed diagnoses and greatly affecting patient management...
July 27, 2018: High-throughput
Didier Jean, Marie-Claude Jaurand
Malignant mesothelioma (MM), a rare and severe cancer, mainly caused as a result of past-asbestos exposure, is presently a public health concern. Current molecular studies aim to improve the outcome of the disease, providing efficient therapies based on the principles of precision medicine. To model the molecular profile of human malignant mesothelioma, animal models have been developed in rodents, wild type animals and genetically engineered mice harbouring mutations in tumour suppressor genes, especially selecting genes known to be inactivated in human malignant mesothelioma...
July 27, 2018: International Journal of Molecular Sciences
Rabab Rashwan, Julius F Varano Della Vergiliana, Sally M Lansley, Hui Min Cheah, Natalia Popowicz, James C Paton, Grant W Waterer, Tiffany Townsend, Ian Kay, Jeremy S Brown, Y C Gary Lee
Pleural infection/empyema is common and its incidence continues to rise. Streptococcus pneumoniae is the commonest bacterial cause of empyema in children and among the commonest in adults. The mesothelium represents the first line of defense against invading microorganisms, but mesothelial cell responses to common empyema pathogens, including S. pneumoniae, have seldom been studied. We assessed mesothelial cell viability in vitro following exposure to common empyema pathogens. Clinical isolates of S. pneumoniae from 25 patients with invasive pneumococcal disease and three reference strains were tested...
2018: PloS One
Kyra B Berg, Sanja Dacic, Caitlyn Miller, Simon Cheung, Andrew Churg
CONTEXT: - The separation of reactive from malignant mesothelial proliferations is often a difficult morphologic problem. There is contradictory information in the literature on whether methylthioadenosine phosphorylase (MTAP) immunohistochemistry can be used for this purpose. OBJECTIVE: - To determine the utility of MTAP immunohistochemistry in distinguishing reactive from malignant mesothelial proliferations. DESIGN: - We stained a tissue microarray containing 20 epithelioid malignant mesotheliomas and 17 reactive mesothelial proliferations...
July 30, 2018: Archives of Pathology & Laboratory Medicine
Stylianos A Michaelides, George D Bablekos, Avgerinos-Romanos S Michailidis, Antonis Analitis, Paraskevi X Kapatsis, Eleni Ellina, Nicoletta Maounis
OBJECTIVES: Given that cytology of adenocarcinoma-induced pleural effusions has a high diagnostic yield, we have comparatively evaluated the cytological information of smears during biphasic sampling of pleural fluid in patients with metastatic pleural adenocarcinoma from various primary sites. METHODS: We studied 25 male and 21 female patients, aged 59.4 ±17.2 years (mean ± SD) with unilateral malignant effusion of varying magnitude due to confirmed adenocarcinoma from various primary sites...
July 25, 2018: Diagnostic Cytopathology
Masaaki Nakayama, Kimio Watanabe, Yoshimitsu Hayashi, Hiroyuki Terawaki, Wan-Jun Zhu, Shigeru Kabayama, Sadayoshi Ito
BACKGROUND: Improved biocompatibility of peritoneal dialysis solution (PDS) is crucial for peritoneal membrane preservation, thereby ensuring long-term peritoneal dialysis (PD) and preventing encapsulating peritoneal sclerosis. We previously reported the protective effect of molecular hydrogen (H2) on mesothelial cells from PDS in nonuremic rats. SUMMARY: In the present study, we examined the effect of H2-containing PDS (commercially available neutral pH type) regarding the protection of peritoneal tissue in experimental chronic kidney disease rats...
2018: Contributions to Nephrology
Alfonso Papparella, Simone Vaccaro, Marina Accardo, Laura De Rosa, Andrea Ronchi, Carmine Noviello
BACKGROUND: Inguinal and/or inguino-scrotal swellings, such as hernia and hydrocele, are among the commonest anomalies in childhood. Hydrocele of the canal of Nuck is an uncommon diagnosis and a rare cause of swelling in women that occurs due to a patent vaginal process. METHODS: From January 2001 to January 2016, 353 female patients 1-14 years of age were admitted to our university hospital division for inguinal swelling. We have performed 403 inguinal approaches, and of these, 399 (99%) had inguinal hernias, 3 (0,74 %) had a cyst of the canal of Nuck, and 1 (0,24%) had a lipoma...
July 23, 2018: Minerva Pediatrica
Chih-Yung Chiu, Tzu-Ping Chen, Jim-Ray Chen, Chia-Jung Wang, Shun-Ying Yin, Shen-Hao Lai, Kin-Sun Wong
OBJECTIVE: To determine gene expression profiles associated with bullae formation in patients with primary spontaneous pneumothorax and to identify candidate genes associated with surgical intervention. METHODS: Twenty-four adolescents with primary spontaneous pneumothorax were enrolled prospectively. A global gene expression analysis of 9 paired lung biopsies (lesion and normal adjacent sites) was performed to identify differentially expressed genes associated with spontaneous pneumothorax...
June 8, 2018: Journal of Thoracic and Cardiovascular Surgery
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