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https://www.readbyqxmd.com/read/30098474/a-plasma-long-noncoding-rna-signature-for-early-detection-of-lung-cancer
#1
Yanli Lin, Qixin Leng, Min Zhan, Feng Jiang
The early detection of lung cancer is a major clinical challenge. Long noncoding RNAs (lncRNAs) have important functions in tumorigenesis. Plasma lncRNAs directly released from primary tumors or the circulating cancer cells might provide cell-free cancer biomarkers. The objective of this study was to investigate whether the lncRNAs could be used as plasma biomarkers for early-stage lung cancer. By using droplet digital polymerase chain reaction, we determined the diagnostic performance of 26 lung cancer-associated lncRNAs in plasma of a development cohort of 63 lung cancer patients and 33 cancer-free individuals, and a validation cohort of 39 lung cancer patients and 28 controls...
August 8, 2018: Translational Oncology
https://www.readbyqxmd.com/read/30098460/following-anticancer-drug-activity-in-cell-lysates-with-dna-devices
#2
Dimithree Kahanda, Naveen Singh, David A Boothman, Jason D Slinker
There is a great need to track the selectivity of anticancer drug activity and to understand the mechanisms of associated biological activity. Here we focus our studies on the specific NQO1 bioactivatable drug, ß-lapachone, which is in several Phase I clinical trials to treat human non-small cell lung, pancreatic and breast cancers. Multi-electrode chips with electrochemically-active DNA monolayers are used to track anticancer drug activity in cellular lysates and correlate cell death activity with DNA damage...
July 30, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/30098333/tusc3-accelerates-cancer-growth-and-induces-epithelial-mesenchymal-transition-by-upregulating-claudin-1-in-non-small-cell-lung-cancer-cells
#3
Siyang Feng, Jianxue Zhai, Di Lu, Jie Lin, Xiaoying Dong, Xiguang Liu, Hua Wu, Anja C Roden, Giovanni Brandi, Simona Tavolari, Andrea Bille, Kaican Cai
Lung cancer is the most frequent cause of cancer-related deaths worldwide, but its molecular pathogenesis is poorly understood. The tumor suppressor candidate 3 (TUSC3) gene is located on chromosome 8p22 and is universally acknowledged as a cancer suppressor. However, our research has demonstrated that TUSC3 expression is significantly upregulated in non-small-cell lung cancer compared to benign controls. In this study, we analyzed the consequences of TUSC3 knockdown or overexpression on the biological functions of non-small-cell lung cancer cell lines...
August 8, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/30098215/a-risk-based-approach-to-identifying-oligometastatic-disease-on-imaging
#4
REVIEW
Nandita M deSouza, Clare M Tempany
Recognition of < 3 metastases in < 2 organs, particularly in cancers with a known predisposition to oligometastatic disease (OMD) (colorectal, prostate, renal, sarcoma and lung), offers the opportunity to focally treat the lesions identified and confers a survival advantage. The reliability with which OMD is identified depends on the sensitivity of the imaging technique used for detection and may be predicted from phenotypic and genetic factors of the primary tumour, which determine metastatic risk. Whole-body or organ-specific imaging to identify oligometastases requires optimization to achieve maximal sensitivity...
August 11, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30098152/effect-of-anlotinib-as-a-third-line-or-further-treatment-on-overall-survival-of-patients-with-advanced-non-small-cell-lung-cancer-the-alter-0303-phase-3-randomized-clinical-trial
#5
Baohui Han, Kai Li, Qiming Wang, Li Zhang, Jianhua Shi, Zhehai Wang, Ying Cheng, Jianxing He, Yuankai Shi, Yizhuo Zhao, Hao Yu, Yang Zhao, Weiqiang Chen, Yi Luo, Lin Wu, Xiuwen Wang, Robert Pirker, Kejun Nan, Faguang Jin, Jian Dong, Baolan Li, Yan Sun
Importance: Anlotinib is a novel multitarget tyrosine kinase inhibitor for tumor angiogenesis and proliferative signaling. A phase 2 trial showed anlotinib to improve progression-free survival with a potential benefit of overall survival, leading to the phase 3 trial to confirm the drug's efficacy in advanced non-small cell lung cancer (NSCLC). Objective: To investigate the efficacy of anlotinib on overall survival of patients with advanced NSCLC progressing after second-line or further treatment...
August 9, 2018: JAMA Oncology
https://www.readbyqxmd.com/read/30098066/combined-inhibition-of-mek-and-pi3k-pathways-overcomes-acquired-resistance-to-egfr-tkis-in-non-small-cell-lung-cancer
#6
Hiroki Sato, Hiromasa Yamamoto, Masakiyo Sakaguchi, Kazuhiko Shien, Shuta Tomida, Tadahiko Shien, Hirokuni Ikeda, Minami Hatono, Hidejiro Torigoe, Kei Namba, Takahiro Yoshioka, Eisuke Kurihara, Yusuke Ogoshi, Yuta Takahashi, Junichi Soh, Shinichi Toyooka
Compensatory activation of the signal transduction pathways is one of the major obstacles for the targeted therapy of non-small cell lung cancer (NSCLC). Herein, we present the therapeutic strategy of combined targeted therapy against the MEK and phosphoinositide-3 kinase (PI3K) pathways for acquired resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in NSCLC. We investigated the efficacy of combined trametinib plus taselisib therapy using experimentally established EGFR-TKI-resistant NSCLC cell lines...
August 10, 2018: Cancer Science
https://www.readbyqxmd.com/read/30097999/dna-primase-polypeptide-1-prim1-involves-in-estrogen-induced-breast-cancer-formation-through-activation-of-the-g2-m-cell-cycle-checkpoint
#7
Wei-Hwa Lee, Li-Ching Chen, Chia-Jung Lee, Chi-Cheng Huang, Yuan-Soon Ho, Po-Sheng Yang, Chi-Tang Ho, Hang-Lung Chang, I-Hsuan Lin, Hui-Wen Chang, Yun-Ru Liu, Chih-Hsiung Wu, Shih-Hsin Tu
The DNA primase polypeptide 1 (PRIM1) is responsible for synthesizing small RNA primers for Okazaki fragments generated during discontinuous DNA replication. PRIM1 mRNA expression levels in breast tumor samples were detected by real-time PCR analysis. Xenografted tumor model was established to study the carcinogenic role of PRIM1 and its potential therapeutic applications. The average PRIM1 mRNA (copy number x 103 /μg) expression was 4.7-fold higher in tumors than in normal tissue (*p = 0.005, n = 254). PRIM1 was detected preferentially at a higher level (> 40-fold) in poorly differentiated tumor tissues (n = 46) compared with more highly differentiated tumors tissues (n = 10) (*p = 0...
August 11, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/30097856/selenious-%C3%AE-lactoglobulin-induces-the-apoptosis-of-human-lung-cancer-a549-cells-via-an-intrinsic-mitochondrial-pathway
#8
Guo-Qiang Zheng, Hai-Yu Ji, Shao-Jing Zhang, Juan Yu, An-Jun Liu
In this study, the cytotoxic activity of selenious-β-lactoglobulin (Se-β-Lg) and the anticancer mechanism were investigated in human lung cancer A549 cells in vitro. MTT assay showed that Se-β-Lg at 200 μg/mL exhibited a significant suppression effect on A549 cells and the maximum inhibition rate reached 90% after 72 h treatment. Flow cytometry analysis revealed that 200 μg/mL of Se-β-Lg induced cell cycle arrest at G0 /G1 phase. Cell apoptosis was induced via the generation of reactive oxygen species (ROS) and the decrease of mitochondrial membrane potential (ΔΨm) in a time-dependent manner...
August 10, 2018: Cytotechnology
https://www.readbyqxmd.com/read/30097782/lower-circulating-androgens-are-associated-with-overall-cancer-risk-and-prostate-cancer-risk-in-men-aged-25-84-years-from-the-busselton-health-study
#9
Yi X Chan, Matthew W Knuiman, Mark L Divitini, David J Handelsman, John P Beilby, Bu B Yeap
Androgens, notably testosterone (T), have been implicated in development of several common cancers and prostate cancer; however, precise mechanisms remain unclear. This study assessed prospective associations of serum T, dihydrotestosterone (DHT) and estradiol (E2) with overall cancer (excluding skin cancer), prostate, colorectal and lung cancer risk in 1574 community-dwelling men aged 25-84 years. Sex hormones were assayed using mass spectrometry and men were followed for 20 years with outcomes ascertained using data linkage...
August 10, 2018: Hormones & Cancer
https://www.readbyqxmd.com/read/30097569/notch3-dependent-%C3%AE-catenin-signaling-mediates-egfr-tki-drug-persistence-in-egfr-mutant-nsclc
#10
Rajeswara Rao Arasada, Konstantin Shilo, Tadaaki Yamada, Jianying Zhang, Seiji Yano, Rashelle Ghanem, Walter Wang, Shinji Takeuchi, Koji Fukuda, Nobuyuki Katakami, Keisuke Tomii, Fumitaka Ogushi, Yasuhiko Nishioka, Tiffany Talabere, Shrilekha Misra, Wenrui Duan, Paolo Fadda, Mohammad A Rahman, Patrick Nana-Sinkam, Jason Evans, Joseph Amann, Elena E Tchekneva, Mikhail M Dikov, David P Carbone
EGFR tyrosine kinase inhibitors cause dramatic responses in EGFR-mutant lung cancer, but resistance universally develops. The involvement of β-catenin in EGFR TKI resistance has been previously reported, however, the precise mechanism by which β-catenin activation contributes to EGFR TKI resistance is not clear. Here, we show that EGFR inhibition results in the activation of β-catenin signaling in a Notch3-dependent manner, which facilitates the survival of a subset of cells that we call "adaptive persisters"...
August 10, 2018: Nature Communications
https://www.readbyqxmd.com/read/30097536/the-continuum-of-screening-and-early-detection-awareness-and-faster-diagnosis-of-lung-cancer
#11
EDITORIAL
Michael D Peake, Neal Navani, David R Baldwin
No abstract text is available yet for this article.
August 10, 2018: Thorax
https://www.readbyqxmd.com/read/30097507/comparative-proteomics-reveals-a-diagnostic-signature-for-pulmonary-head-and-neck-cancer-metastasis
#12
Hanibal Bohnenberger, Lars Kaderali, Philipp Ströbel, Diego Yepes, Uwe Plessmann, Neekesh V Dharia, Sha Yao, Carina Heydt, Sabine Merkelbach-Bruse, Alexander Emmert, Jonatan Hoffmann, Julius Bodemeyer, Kirsten Reuter-Jessen, Anna-Maria Lois, Leif Hendrik Dröge, Philipp Baumeister, Christoph Walz, Lorenz Biggemann, Roland Walter, Björn Häupl, Federico Comoglio, Kuan-Ting Pan, Sebastian Scheich, Christof Lenz, Stefan Küffer, Felix Bremmer, Julia Kitz, Maren Sitte, Tim Beißbarth, Marc Hinterthaner, Martin Sebastian, Joachim Lotz, Hans-Ulrich Schildhaus, Hendrik Wolff, Bernhard C Danner, Christian Brandts, Reinhard Büttner, Martin Canis, Kimberly Stegmaier, Hubert Serve, Henning Urlaub, Thomas Oellerich
Patients with head-and-neck cancer can develop both lung metastasis and primary lung cancer during the course of their disease. Despite the clinical importance of discrimination, reliable diagnostic biomarkers are still lacking. Here, we have characterised a cohort of squamous cell lung (SQCLC) and head-and-neck (HNSCC) carcinomas by quantitative proteomics. In a training cohort, we quantified 4,957 proteins in 44 SQCLC and 30 HNSCC tumours. A total of 518 proteins were found to be differentially expressed between SQCLC and HNSCC, and some of these were identified as genetic dependencies in either of the two tumour types...
August 10, 2018: EMBO Molecular Medicine
https://www.readbyqxmd.com/read/30097357/study-protocol-of-the-nvalt25-eldapt-trial-selecting-the-optimal-treatment-for-older-patients-with-stage-iii-non-small-cell-lung-cancer
#13
Elisabeth J M Driessen, Maryska L G Janssen-Heijnen, Huub A Maas, Anne-Marie C Dingemans, Judith G M van Loon
BACKGROUND: Patients aged 75 years or older with stage III non-small-cell lung cancer (NSCLC) are underrepresented in clinical trials, leading to a lack of evidence for selection of the optimal treatment strategy. Information on benefits and harms of concurrent chemoradiotherapy among medically fit elderly patients is largely unknown, and reliable tools are needed to distinguish fit from frail patients for treatment selection. Also, information regarding quality of life during and after treatment is scarce...
July 9, 2018: Clinical Lung Cancer
https://www.readbyqxmd.com/read/30097256/enhanced-treatment-of-lung-cancer-by-metronomic-therapy-with-oral-pemetrexed
#14
EDITORIAL
Kinam Park
No abstract text is available yet for this article.
August 28, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/30097241/ablative-stereotactic-radiotherapy-for-oligometastatic-colorectal-cancer-systematic-review
#15
REVIEW
J Kobiela, P Spychalski, G Marvaso, D Ciardo, V Dell'Acqua, F Kraja, A Błażyńska-Spychalska, A J Łachiński, A Surgo, R Glynne-Jones, B A Jereczek-Fossa
BACKGROUND: SBRT is a novel modality in treatment for oligometastatic colorectal cancer. We aimed to perform a systematic review of results of SBRT in maintaining LC (local control) for CRC liver and lung oligometastases. MATERIALS AND METHODS: The review was performed according to PRISMA and PICO guidelines. Database search using keywords: stereotactic, colon, colorectal, cancer, sbrt, sabr returned 457 results. 15 were included in the study. Only cohorts with CRC histology and reported LC were included...
September 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/30097239/do-sabr-related-toxicities-for-lung-cancer-depend-on-treatment-delivery
#16
REVIEW
Stamati Morias, Loredana Gabriela Marcu, Michala Short, Eileen Giles, Eva Bezak
Stereotactic ablative radiation therapy for lung cancer is an advanced technique where tumours are ablated with hypofractionated radiation doses, with a high degree of accuracy. The aim of this paper is to review the available literature and to discuss the SABR-induced toxicities for lung malignancies as a function of radiation delivery technique. A Medline search was conducted to identify the appropriate literature to fulfil the aim of this review and data from all applicable papers were collated and analysed...
September 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/30097235/immune-checkpoint-inhibitors-in-non-small-cell-lung-cancer-a-tool-to-improve-patients-selection
#17
REVIEW
Giuseppe Luigi Banna, Francesco Passiglia, Francesca Colonese, Stefania Canova, Jessica Menis, Alfredo Addeo, Antonio Russo, Diego Luigi Cortinovis
The identification of reliable predictive biomarkers of efficacy or resistance to immune-oncology (I-O) agents is a major issue for translational research and clinical practice. However, along with PDL1 and molecular features other clinical, radiological and laboratory factors can be considered for the selection of those patients who would not be the best candidate for immune-checkpoint inhibitors (ICPIs). We examined these factors, emerging from the results of currently available studies in non-small cell lung cancer (NSCLC), aiming to provide a useful and manageable tool which can help Oncologists in their everyday clinical practice...
September 2018: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/30097113/turmeric-extract-with-absorbable-curcumin-has-potent-anti-metastatic-effect-in-vitro-and-in-vivo
#18
Mingyue Li, Grace Gar-Lee Yue, Stephen Kwok-Wing Tsui, Kwok-Pui Fung, Clara Bik-San Lau
BACKGROUND: Curcumin, a well-studied component in turmeric, exhibits potent antitumor effects in colorectal cancer. Previous studies showed that turmerones raised the accumulation of curcumin inside colonic cells, and curcumin present in turmeric ethanolic extract had enhanced anti-tumor activities in mice. Metastasis accounts for more than 90% colorectal cancer deaths. However, the anti-metastatic effect of turmeric extract on colorectal cancer is still unknown. METHODS: In the present study, colony formation, scratch, transwell and Western blot were used to assess colony formation, motility, migration and underlying mechanisms in vitro, respectively...
July 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30097112/in-silico-and-in-vitro-analysis-of-coumarin-derivative-induced-anticancer-effects-by-undergoing-intrinsic-pathway-mediated-apoptosis-in-human-stomach-cancer
#19
Haribalan Perumalsamy, Karuppasamy Sankarapandian, Karpagam Veerappan, Sathishkumar Natarajan, Narendran Kandaswamy, Lakshmi Thangavelu, Sri Renukadevi Balusamy
BACKGROUND: Coumarin plays a vital role in drug discovery process due to its diverse biologically active components. Recently, coumarin derivatives are paying attention to treat various diseases including cancer. The effect of coumarin derivatives on gastric cancer is not well established although gastric cancer being the fourth leading cancer. Therefore, we attempt to study the effect of styrene substituted biscoumarin (SSBC) to induce apoptosis and inhibit cancer proliferation using in silico and in vitro approaches...
July 15, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/30097033/survival-after-repeated-surgery-for-lung-cancer-with-idiopathic-pulmonary-fibrosis-a-retrospective-study
#20
Seijiro Sato, Yuki Shimizu, Tatsuya Goto, Akihiko Kitahara, Terumoto Koike, Hiroyuki Ishikawa, Takehiro Watanabe, Masanori Tsuchida
BACKGROUND: Patients with idiopathic pulmonary fibrosis (IPF) have a high risk of developing lung cancer, but few studies have investigated the long-term outcomes of repeated surgery in such patients. The purpose of this study was to evaluate the surgical outcomes of repeated lung cancer surgery in patients with IPF. METHODS: From January 2001 to December 2015, 108 lung cancer patients with IPF underwent pulmonary resection at two institutions; 13 of these patients underwent repeated surgery for lung cancer, and their data were reviewed...
August 10, 2018: BMC Pulmonary Medicine
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