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lunge cancer

Sang Hun Lee, Jihwan Song, Byungrae Cho, SoonGweon Hong, Ori Hoxha, Taewook Kang, Dongchoul Kim, Luke P Lee
Microfluidic polymerase chain reaction (PCR) has been of great interest owing to its ability to perform rapid and specific nucleic acid amplification and analysis on small volumes of samples. One of the major drawbacks of microfluidic PCR is bubble generation and reagent evaporation, which can cause malfunctions. Here, through theoretical modeling and characterization of bubble behavior, we propose a bubble-free microfluidic PCR device via controlled fluid transfer. Our approach exploits a thin impermeable polyethylene (PE) top layer that minimizes the generation of bubbles by inhibiting mass transport along a vertical direction...
October 11, 2018: Biosensors & Bioelectronics
Xicheng Liu, Yanhua Tang, Xiangdong He, Xingxing Ge, Jiao Liu, Xiaoyu Meng, Mingxiao Shao, Yingmin Jin, Laijin Tian, Zhe Liu
Four new triphenyltin(IV) acylhydrazone compounds of the type Ph3 SnCH2 CH2 CONHN=R (where Ph = phenyl; R = isopropyl, isobutyl, cyclopentyl and cyclooctyl) were synthesized and characterized by elemental analysis, infrared spectrum (IR), nuclear magnetic resonance spectrum (NMR) and mass spectrum (MS). The crystal structures were determined and showed that tin atoms were four-coordinated and adopted a pseudo-tetrahedron configuration. Tin(IV) compounds show excellent bovine serum albumin (BSA) binding properties, and can oxidize nicotinamide-adenine dinucleotid (NADH) to generate reactive oxygen species (ROS), which inducing apoptosis effectively...
November 24, 2018: Journal of Inorganic Biochemistry
Bo Zhang, Zhaodi Xie, Bin Li
BACKGROUND: Accumulating studies have reported that GLUT1 is aberrantly expressed in lung cancer; nevertheless, the clinicopathologic significance and the prognostic role of GLUT1 still remain controversial. The aim of this meta-analysis was to identify the clinicopathologic and prognostic implications of the GLUT1 expression in lung cancer patients. MATERIALS AND METHODS: Databases with literature published in English, including Cochrane Library, Embase, Web of Science, and PubMed, and the China National Knowledge Infrastructure (CNKI) and WanFang database in Chinese were searched comprehensively for relevant studies in August 2017...
December 12, 2018: Gene
By Arabo Avanes, Gal Lenz, Jamil Momand
The PPP1R1B gene is located on chromosome 17q12 (39,626,208-39,636,626[GRCh38/hg38]), which codes for multiple transcripts and two experimentally-documented proteins Darpp-32 and t-Darpp. Darpp-32 (Dopamine and cAMP Regulated Phosphoprotein), discovered in the early 1980s, is a protein whose phosphorylation is upregulated in response to cAMP in dopamine-responsive tissues in the brain. It's phosphorylation profile modulates its ability to bind and inhibit Protein Phosphatase 1 activity, which, in turn, controls the activity of hundreds of phosphorylated proteins...
December 12, 2018: Biochemical Pharmacology
Ryosuke Araki, Takayuki Keira, Yutaka Masuda, Tsuneaki Tanaka, Hideki Yamada, Tomoyuki Hamamoto
WHAT IS KNOWN AND OBJECTIVE: Pemetrexed/carboplatin combination chemotherapy has shown efficacy as a first-line treatment for advanced non-small-cell lung cancer. However, severe haematotoxicity is often observed during this combination chemotherapy. Some studies have suggested that concomitant drugs may be the risk factors for severe adverse events. However, those studies identified the predictive risk factors without paying attention to the relative dose intensities (RDIs) of the anticancer drugs...
December 15, 2018: Journal of Clinical Pharmacy and Therapeutics
G Layer
Screening is a special issue in medical questions concerning disease prevention. Preconditions for screening are clearly defined by the World Health Organization. High prevalence, effectiveness of therapy, availability of accepted test procedure and consensus concerning the economic concerns are necessary for successful implementation of a screening program. Preventive diagnostic studies can only be understood if one is familiar with the statistical terms sensitivity, specificity, prevalence, incidence and bias (especially overdiagnosis and lead time bias)...
December 14, 2018: Der Radiologe
E Eisenhuber, C Schaefer-Prokop, G Mostbeck
Lung cancer is a histologically, immunologically and therefore morphologically and functionally very heterogeneous group of neoplasms with the highest cancer mortality worldwide. Therefore, the range of diseases mimicking lung cancer is also very broad and includes congenital, infectious and inflammatory changes as well as other benign space-occupying lesions and other primary and secondary pulmonary neoplasms. The difficulty in radiology lies in the ability to diagnose lung cancer with a high degree of certainty...
December 14, 2018: Der Radiologe
Bertram J Jobst, Oliver Weinheimer, Torben Buschulte, Mila Trauth, Jan Tremper, Stefan Delorme, Nikolaus Becker, Erna Motsch, Marie-Luise Groß, Anke Trotter, Monika Eichinger, Hans-Ulrich Kauczor, Mark O Wielpütz
OBJECTIVES: To longitudinally investigate smoking cessation-related changes of quantitative computed tomography (QCT)-based airway metrics in a group of heavy smokers. METHODS: CT scans were acquired in a lung cancer screening population over 4 years at 12-month intervals in 284 long-term ex-smokers (ES), 405 continuously active smokers (CS), and 31 subjects who quitted smoking within 2 years after baseline CT (recent quitters, RQ). Total diameter (TD), lumen area (LA), and wall percentage (WP) of 1st-8th generation airways were computed using airway analysis software...
December 14, 2018: European Radiology
Lauren Lewis, Grace A Chappell, Tetyana Kobets, Bridget E O'Brian, Dewakar Sangaraju, Oksana Kosyk, Wanda Bodnar, Natalia Y Tretyakova, Igor P Pogribny, Ivan Rusyn
Exposure to environmental chemicals has been shown to have an impact on the epigenome. One example is a known human carcinogen 1,3-butadiene which acts primarily by a genotoxic mechanism, but also disrupts the chromatin structure by altering patterns of cytosine DNA methylation and histone modifications. Sex-specific differences in 1,3-butadiene-induced genotoxicity and carcinogenicity are well established; however, it remains unknown whether 1,3-butadiene-associated epigenetic alterations are also sex dependent...
December 14, 2018: Archives of Toxicology
Chiara Ventre, Sian Nowell, Catriona Graham, Doug Kidd, Christos Skouras, Damian J Mole
INTRODUCTION: Severe acute pancreatitis (AP) requiring critical care admission (ccAP) impacts negatively on long-term survival. OBJECTIVE: To document organ-specific new morbidity and identify risk factors associated with premature mortality after an episode of ccAP. DESIGN: Cohort study. SETTING: Electronic healthcare registries in Scotland. PARTICIPANTS: The ccAP cohort included 1471 patients admitted to critical care with AP between 1 January 2008 and 31 December 2010 followed up until 31 December 2014...
December 14, 2018: BMJ Open
Marko Roblek, Darya Protsyuk, Paul F Becker, Cristina Stefanescu, Christian Gorzelanny, Jesus F Glaus Garzon, Lucia Knopfova, Mathias Heikenwalder, Bruno Luckow, Stefan W Schneider, Lubor Borsig
Increased levels of the chemokine CCL2 in cancer patients are associated with poor prognosis. Experimental evidence suggests that CCL2 correlates with inflammatory monocyte recruitment and induction of vascular activation; but the functionality remains open. Here, we show that endothelial Ccr2 facilitates pulmonary metastasis using an endothelial-specific Ccr2-deficient mouse model (Ccr2ecKO). Similar levels of circulating monocytes and equal leukocyte recruitment to metastatic lesions of Ccr2ecKO and Ccr2fl/fl littermates were observed...
December 14, 2018: Molecular Cancer Research: MCR
Elizabeth A David, Stina W Andersen, Laurel A Beckett, Joy Melnikow, James M Clark, Lisa M Brown, David T Cooke, Karen Kelly, Robert J Canter
OBJECTIVE: Overall survival (OS) for advanced stage (IIIA-IV) non-small cell lung cancer (NSCLC) is highly variable, and retrospective data show a survival advantage for patients receiving therapeutic intent pulmonary resection. We hypothesized that this variability in OS can be modeled separately by stage to allow a personalized estimate of OS. METHODS: In a cohort of patients with advanced-stage NSCLC from the National Cancer Database, we assessed the accuracy of Surgical Selection Score (SSS) to predict OS using Cox proportional hazards models and determined by stage the effect of surgery on survival among people with similarly high levels of SSS...
November 14, 2018: Journal of Thoracic and Cardiovascular Surgery
Camille Carles, Catherine Verdun-Esquer, Isabelle Leclerc, Isabelle Baldi
Since 2008, cancer became the first cause of death in France, exceeding cardiovascular diseases. The part of occupational cancers is close to 5% of all cancers but may still be widely underestimated. The detection of occupational cancer risk factors remains complicated. Indeed, most occupational risk factors are also present in the general environment. Thus far, 36 substances and 13 activities have been classified as carcinogenic (Group 1) and 37 substances and 6 activities have been classified as probably carcinogenic (Group 2A) by the International Agency for Research on Cancer (IARC)...
December 11, 2018: Bulletin du Cancer
Ai-Wu Shi, Xiao-Feng Shen, Hong-Juan Ding, Yao-Qiu Liu, Li Meng, Bill Kalionis
BACKGROUND: Gestational diabetes mellitus is strongly related to the risk of pancreatic cancer in pregnant women, but gestational diabetes can precede a diagnosis of pancreatic cancer by many years. Women with a history of gestational diabetes showed a relative risk of pancreatic cancer of 7.1. Pancreatic adenocarcinoma is one of the most common malignancies associated with thromboembolic events. A clinical study showed that thromboembolic events were detected in 36% of patients diagnosed as having pancreatic cancer...
December 15, 2018: Journal of Medical Case Reports
Chen-Hung Ting, Jyh-Yih Chen
Non-small cell lung cancer (NSCLC) is among the leading causes of human mortality due to a lack of effective treatments. Conventional chemotherapies affect healthy cells and cause multidrug resistance, while tumors may eventually develop resistance to less-toxic targeted therapies. Thus, the need to develop novel therapies for NSCLC is urgent. Here, we show that Nile tilapia-derived Tilapia piscidin (TP) 4 is cytotoxic to a panel of NSCLC cells with different genetic profiles. We observed that TP4 triggers NSCLC cell death through the necrosis and combining TP4 with potent Epidermal growth factor receptor (EGFR)- tyrosine kinase inhibitors (TKI)s, Erlotinib, and Gefitinib, improved drug responses in EGFR-mutated NSCLC cells, but not in EGFR-wild-type NSCLC cells...
December 13, 2018: Marine Drugs
Heng-Long Wang, Jung-Che Chang, Li-Wen Fang, Hsia-Fen Hsu, Li-Chiun Lee, Jyh-Ferng Yang, Ming-Tsai Liang, Pei-Chi Hsiao, Chao-Ping Wang, Shih-Wei Wang, Chi-Chang Chang, Jer-Yiing Houng
Bulnesia sarmientoi (BS) has long been used as an analgesic, wound-healing and anti-inflammatory medicinal plant. The aqueous extract of its bark has been demonstrated to have anti-cancer activity. This study investigated the anti-proliferative and anti-metastatic effects of BS supercritical fluid extract (BSE) on the A549 and H661 lung cancer cell lines. The cytotoxicity on cancer cells was assessed by an MTT assay. After 72 h treatment of A549 and H661 cells, the IC50 values were 18.1 and 24.7 μg/mL, respectively...
December 13, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Aluwani Shiridor Mashau, Mugera Wilson Gitari, Segun Ajayi Akinyemi
This study evaluated the physicochemical and mineralogical properties, mobile chemical species bioavailability and translocation in Brassica juncea and Spinacea oleracea L. plants of a South African coal-fired power utility. Coal-fly-ash (CFA) disposal is associated with various environmental and health risks, including air, soil, surface, and groundwater pollution due to the leaching of toxic heavy metals; these ends up in food webs affecting human health, while repeated inhalation causes bronchitis, silicosis, hair loss, and lung cancer...
December 13, 2018: International Journal of Environmental Research and Public Health
Song Zhang, Yuankai Guan, Xiangli Liu, Mingxiu Ju, Qigang Zhang
OBJECTIVE: To explore the role of long non-coding RNA DLEU1 in the tumorigenesis and progression of non-small cell lung cancer (NSCLC) and the underlying mechanisms. METHODS: The expression of DLEU1 in NSCLC tumor tissues and adjacent normal tissues was evaluated using bioinformatics analysis and qPCR. The effects of DLEU1 overexpression or deficiency on cell proliferation, apoptosis, migration and invasion were explored experimentally. Additionally, the impact of DLEU1 up-regulation on tumourigenesis was also assessed in vivo...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Xing Su, Yueping Li, Meng Jiang, Jinglin Zhu, Chunli Zheng, Xuetong Chen, Jun Zhou, Yan Li, Wei Xiao, Yonghua Wang
Non-small cell lung cancer (NSCLC) has become one of the most general malignancies in the world and has been shown to be the leading cause of cancer-related deaths. Traditional Chinese medicine (TCM) is considered to be a useful medicine for survival, and has been used in Asia for thousands of years. Hedyotis diffusa Willd (HDW) is an important folk herb that is used in clinical treatment of various cancers in various Chinese medicine prescriptions. However, its underlying mechanism of action remains unclear...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yudong Xie, Yanping Lv, Yanli Zhang, Zhenzhen Liang, Lili Han, Yiyang Xie
LATS2 is a classical tumor suppressor that affects non-small cell lung cancer proliferation and mobilization. However, its role in lung cancer cell apoptosis is unknown. The aim of our study is to explore whether LATS2 activates mitochondria-related apoptosis in lung cancer cells. In the present study, A549 non-small cell lung cancer cells were transfected with a LATS2 adenovirus to induce LATS2 overexpression. Cell apoptosis was evaluated via the MTT assay, TUNEL staining, western blotting, trypan blue staining and ELISA...
January 2019: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
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