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https://www.readbyqxmd.com/read/30335064/-chronic-diseases-precancer-and-cancer-of-the-lung-which-are-associated-with-pathology-of-the-club-cells-of-respiratory-and-terminal-bronchioles
#1
S A Demura, E A Kogan, V L Goryachkina
The review of the literature deals with the participation of Clara cells now called club cells (CCs) of the epithelium in the respiratory and terminal bronchioles in the pathogenesis and morphogenesis of chronic inflammatory diseases, precancer, and cancer of the lung, which develop in the respiratory segments. The review summarizes data on the histophysiology of CCs and their participation in the pathogenesis and morphogenesis of chronic interstitial lung diseases, pneumoconiosis, chronic obstructive diseases, adenomatosis, and adenocarcinoma of the lung...
2018: Arkhiv Patologii
https://www.readbyqxmd.com/read/30334925/uveal-metastasis-based-on-patient-age-in-1-111-patients-comparison-of-clinical-features-and-outcomes-per-age-category
#2
Carol L Shields, Luis A Acaba-Berrocal, Evan B Selzer, Eileen L Mayro, Jennifer H Newman, Kunal Malik, R Joel Welch, Jerry A Shields
PURPOSE: To evaluate clinical features and survival outcomes of uveal metastasis based on patient age. METHODS: Retrospective analysis of all patients with uveal metastasis evaluated on the Ocular Oncology Service, Wills Eye Hospital, Philadelphia, PA, USA between February 1, 1974 and June 1, 2017. The features and outcomes were analyzed based on patient age classified as children (0-20 years), young adults (21-40 years), middle [aged] adults (41-60 years), older adults (61-80 years) and senior adults (81-100 years)...
October 16, 2018: Retina
https://www.readbyqxmd.com/read/30334786/knowledge-based-collaborative-deep-learning-for-benign-malignant-lung-nodule-classification-on-chest-ct
#3
Yutong Xie, Yong Xia, Jianpeng Zhang, Yang Song, Dagan Feng, Michael Fulham, Weidong Cai
The accurate identification of malignant lung nodules on chest CT is critical for the early detection of lung cancer, which also offers patients the best chance of cure. Deep learning methods have recently been successfully introduced to computer vision problems, although substantial challenges remain in the detection of malignant nodules due to the lack of large training datasets. In this paper, we propose a multi-view knowledge-based collaborative (MV-KBC) deep model to separate malignant from benign nodules using limited chest CT data...
October 17, 2018: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/30334618/feasibility-of-early-multimodal-interventions-for-elderly-patients-with-advanced-pancreatic-and-non-small-cell-lung-cancer
#4
Tateaki Naito, Shuichi Mitsunaga, Satoru Miura, Noriatsu Tatematsu, Toshimi Inano, Takako Mouri, Tetsuya Tsuji, Takashi Higashiguchi, Akio Inui, Taro Okayama, Teiko Yamaguchi, Ayumu Morikawa, Naoharu Mori, Toshiaki Takahashi, Florian Strasser, Katsuhiro Omae, Keita Mori, Koichi Takayama
BACKGROUND: Combinations of exercise and nutritional interventions might improve the functional prognosis for cachectic cancer patients. However, high attrition and poor compliance with interventions limit their efficacy. We aimed to test the feasibility of the early induction of new multimodal interventions specific for elderly patients with advanced cancer Nutrition and Exercise Treatment for Advanced Cancer (NEXTAC) programme. METHODS: This was a multicentre prospective single-arm study...
October 18, 2018: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/30334568/direct-comparison-of-2%C3%A2-amino-3%C3%A2-11c-isobutyric-acid-and-2%C3%A2-amino-11c-methyl%C3%A2-isobutyric-acid-uptake-in-eight-lung-cancer-xenograft-models
#5
Hitomi Sudo, Atsushi B Tsuji, Aya Sugyo, Maki Okada, Koichi Kato, Ming-Rong Zhang, Tsuneo Saga, Tatsuya Higashi
The non‑natural amino acid positron emission tomography tracers, 2‑amino[3‑11C]isobutyric acid ([3‑11C]AIB) and 2‑amino[11C]methyl‑isobutyric acid ([11C]MeAIB), are metabolically stable in vivo and accumulate in tumors. [3‑11C]AIB is transported into cells mainly via the amino acid transport system A and partially via systems L and ASC, whereas [11C]MeAIB is transported into cells specifically via system A. How transport via the different systems affects the tumor uptake of these tracers, however, is unclear...
October 16, 2018: International Journal of Oncology
https://www.readbyqxmd.com/read/30334450/pcr-based-detection-of-egfr-alk-kras-and-braf-mutations-in-russian-patients-with-lung-adenocarcinoma-a-single-center-experience
#6
N V Mitiushkina, M M Holmatov, A R Venina, V I Tiurin, G A Yanus, T N Sokolova, O S Yatsuk, O A Zaitseva, A O Ivantsov, E Sh Kuligina, A V Togo, E N Imyanitov
In contrast to other countries with predominantly White population, Russian smoking-related lung cancers (LC) are represented mainly by squamous cell carcinomas, while approximately a half of lung adenocarcinomas (AdCa) observed in this country are not related to tobacco consumption. Given that smoking significantly influences the probability of the presence of actionable mutations in LC, one would expect that Russian lung AdCa patients would differ from other Whites with respect to distribution of EGFR, ALK, KRAS and BRAF mutations...
September 4, 2018: Neoplasma
https://www.readbyqxmd.com/read/30334447/ctbp2-promotes-proliferation-and-reduces-drug-sensitivity-of-non-small-cell-lung-cancer-via-the-wnt-%C3%AE-catenin-pathway
#7
D P Wang, L L Gu, Q Xue, H Chen, G X Mao
The C-terminal binding protein 2 (CtBP2) is crucial for the activation of the Wnt/β-catenin pathway and regulates cellular processes of significance in multiple cancer cells. However, the role of CtBP2 in non-small cell lung cancer (NSCLC) remains uncertain. Our western blotting and immunohistochemistry assays revealed that CtBP2 expression was obviously increased in NSCLC tissues and cells. In addition, chi-square test and Kaplan-Meier analysis showed that overexpression of CtBP2 correlated with a more invasive tumor phenotype and poor prognosis...
September 4, 2018: Neoplasma
https://www.readbyqxmd.com/read/30334403/expression-of-il-17a-e-and-f-and-their-receptors-in-non-small-cell-lung-cancer
#8
Q Huang, X C Ma, X Yang, W Wang, Y Li, Z Lv, C J Corrigan, Y Chen, S Ying
Lung cancer is the leading cause of cancer-related morbidity and mortality worldwide. Interaction of nascent or established lung tumour cells with various cytokines and infiltrating immune cells has been implicated in lung cancer pathogenesis. In this study, we systematically analysed immunoreactivity for IL-17A, IL-17E and IL-17F and their relevant receptors in the lung sections from non-small cell lung cancer (NSCLC) and normal control. Immunoreactivity for IL-17A, IL-17F, IL-17RA and IL- 17RC, but not IL-17RB was significantly elevated in NSCLC compared with controls, while IL-17E was reduced...
September 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/30334239/a-patient-with-egfr-mutated-lung-cancer-progressing-on-erlotinib-evaluating-for-a-t790m-mutation-with-limited-tissue
#9
Emily Wynja Msiv, Jenna Hove, Steven F Powell
No abstract text is available yet for this article.
October 17, 2018: Oncology (Williston Park, NY)
https://www.readbyqxmd.com/read/30333935/symptom-management-strategies-for-patients-receiving-anaplastic-lymphoma-kinase-inhibitors-for-non-small-cell-lung-cancer
#10
REVIEW
Jennifer Jacky, Christina Baik
No abstract text is available yet for this article.
November 2017: Journal of the Advanced Practitioner in Oncology
https://www.readbyqxmd.com/read/30333876/microrna-133a-downregulated-egfr-expression-in-human-non-small-cell-lung-cancer-cells-via-akt-erk-signaling
#11
Nannan Guo, Yingnan Zhao, Wen Zhang, Shaojun Li, Shanshan Li, Jianqi Yu
MicroRNAs (miRNAs) may serve important roles in the regulation of human non-small cell lung cancer (NSCLC) cell growth and apoptosis. To the best of our knowledge, the present study was the first to explore the role of miRNA-133a/epidermal growth factor receptor (EGFR) in regulating NSCLC cell growth and apoptosis via the AKT/extracellular signal-regulated kinase (ERK) signaling pathway. It was determined that miRNA-133a expression was lower in NSCLC tissue than in the adjacent mucosae. Additionally, EGFR expression in the NSCLC tissue was higher compared with in the adjacent mucosae...
November 2018: Oncology Letters
https://www.readbyqxmd.com/read/30333870/crizotinib-induces-apoptosis-of-lung-cancer-cells-through-jak-stat-pathway
#12
Hongmin Lu, Shibo Wu, Huafei Chen, Ying Huang, Guoqin Qiu, Lingxiang Liu, Yong Li
Effect of crizotinib on apoptosis of lung cancer cells was investigated. Human non-small cell lung adenocarcinoma H2228 cells were cultured in the presence of 0, 20, 40, 80, 160 and 320 nmol/l of crizotinib for 3 days, respectively. The inhibition rate of cell proliferation was measured by MTT assay, and half maximal inhibitory concentration (IC50 ) was calculated. Cell apoptosis was detected by flow cytometry. Transwell assay was performed to detect cell migration. Expression of Janus protein tyrosine kinase (JAK) and signal transducer and activator of transcription (STAT) proteins was detected by western blot analysis...
November 2018: Oncology Letters
https://www.readbyqxmd.com/read/30333868/role-of-nutritional-support-for-postoperative-recovery-of-respiratory-function-in-patients-with-primary-lung-cancer
#13
Jinhong Yang, Qianqian Zhang, Xiaoli Wang
This study explored the role of nutritional support for postoperative recovery of respiratory function in patients with primary lung cancer. Clinical data of 182 patients with primary lung cancer who were admitted to Weifang People's Hospital from January 2013 to December 2015 and underwent lung cancer surgery, were collected and retrospectively analyzed. According to the postoperative diet plan, patients were divided into two groups: General diet group (n=80) and nutrition therapy group (n=102). Patients in the general diet group were given a general diet without any nutritional instruction, whereas the patients in the nutrition therapy group were given an enteral nutritional supplement in addition to a general diet...
November 2018: Oncology Letters
https://www.readbyqxmd.com/read/30333862/mir-339-5p-inhibits-lung-adenocarcinoma-invasion-and-migration-by-directly-targeting-bcl6
#14
Peng Li, Huaqing Liu, Yanmeng Li, Yan Wang, Lin Zhao, Hui Wang
Lung adenocarcinoma (LA) is a common non-small cell lung cancer, but effective biomarkers to diagnose early LA are still lacking. Increasing evidence has indicated that the dysregulation of microRNAs (miRNAs) play crucial roles in LA progression. miR-339-5p has been recently confirmed to exert crucial functions in various cancers. Nevertheless, molecular mechanisms and effects of miR-339-5p on LA development still remain vague. In the present research, miR-339-5p expression was downregulated in human LA tissues...
November 2018: Oncology Letters
https://www.readbyqxmd.com/read/30333826/enzymatic-inactivation-of-oxysterols-in-breast-tumor-cells-constraints-metastasis-formation-by-reprogramming-the-metastatic-lung-microenvironment
#15
Marta A Moresco, Laura Raccosta, Gianfranca Corna, Daniela Maggioni, Matias Soncini, Silvio Bicciato, Claudio Doglioni, Vincenzo Russo
Recent evidence indicates that immune cells contribute to the formation of tumor metastases by regulating the pre-metastatic niche. Whether tumor-derived factors involved in primary tumor formation play a role in metastasis formation is poorly characterized. Oxysterols act as endogenous regulators of lipid metabolism through the interaction with the nuclear Liver X Receptors-(LXR)α and LXRβ. In the context of tumor development, they establish a pro-tumor environment by dampening antitumor immune responses, and by recruiting pro-angiogenic and immunosuppressive neutrophils...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/30333500/the-cancer-testes-ct-antigen-hormad1-promotes-homologous-recombinational-dna-repair-and-radioresistance-in-lung-adenocarcinoma-cells
#16
Yanzhe Gao, Jordan Kardos, Yang Yang, Tigist Y Tamir, Elizabeth Mutter-Rottmayer, Bernard Weissman, Michael B Major, William Y Kim, Cyrus Vaziri
The Cancer/Testes (CT) Antigen HORMAD1 is germ cell-restricted and plays developmental roles in generation and processing of meiotic DNA Double Strand Breaks (DSB). Many tumors aberrantly overexpress HORMAD1 yet the potential impact of this CT antigen on cancer biology is unclear. We tested a potential role of HORMAD1 in genome maintenance in lung adenocarcinoma cells. We show that HORMAD1 re-distributes to nuclear foci and co-localizes with the DSB marker γH2AX in response to ionizing radiation (IR) and chemotherapeutic agents...
October 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/30333394/a-low-crizotinib-concentration-in-the-cerebrospinal-fluid-causes-ineffective-treatment-of-anaplastic-lymphoma-kinase-positive-non-small-cell-lung-cancer-with-carcinomatous-meningitis
#17
Tamio Okimoto, Yukari Tsubata, Takamasa Hotta, Megumi Hamaguchi, Mika Nakao, Shun-Ichi Hamaguchi, Akinobu Hamada, Takeshi Isobe
The central nervous system is a common site of relapse in patients receiving crizotinib, which is presumed to be associated with the low concentration of crizotinib in the cerebrospinal fluid (CSF). Our patient received surgical treatment for anaplastic lymphoma kinase-positive stage IIA lung adenocarcinoma. His cancer recurred with brain metastases and carcinomatous meningitis. We started whole-brain radiation therapy (WBRT) and subsequently administered crizotinib. The concentration of crizotinib on day 15 in the plasma was 158 ng/mL, and that in the spinal fluid was 4...
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333385/large-cell-neuroendocrine-carcinoma-of-the-mediastinum-successfully-treated-with-systemic-chemotherapy-after-palliative-radiotherapy
#18
Takeaki Hidaka, Saki Okuzumi, Ako Matsuhashi, Hidenori Takahashi, Kazunori Hata, Seiichiro Shimizu, Yoshinobu Iwasaki
Large cell neuroendocrine carcinoma (LCNEC) is a highly malignant cancer originally found in lung in 1991. In extremely rare occasions, primary LCNEC is found in the mediastinum; approximately 40 of such cases have been reported. Due to the limited number of reported cases, a standardized treatment protocol has yet to be established. We report a case of a 66-year-old woman with primary mediastinal LCNEC who presented with superior vena cava syndrome. Emergent radiotherapy was performed, followed by systemic chemotherapy with cisplatin and etoposide, which resulted in a dramatic tumor reduction...
October 17, 2018: Internal Medicine
https://www.readbyqxmd.com/read/30333361/advanced-lung-cancer-inflammation-index-predicts-outcomes-of-patients-with-pathological-stage-ia-lung-adenocarcinoma-following-surgical-resection
#19
Satoru Kobayashi, Yoko Karube, Takashi Inoue, Osamu Araki, Sumiko Maeda, Yuji Matsumura, Masayuki Chida
PURPOSE: The correlation of advanced cancer with inflammation and/or nutrition factors is well known. Recently, the advanced lung cancer inflammation index (ALI) was developed as a new prognostic tool for patients with advanced lung cancer. In this study, we examined whether ALI results are correlated with prognosis of patients with early stage lung adenocarcinoma who undergo lung resection. METHODS: From January 2009 to December 2014, 544 patients underwent lung resection due to primary lung cancer at Dokkyo Medical University Hospital, of whom 166 with pathological stage IA lung adenocarcinoma were retrospectively investigated in this study...
October 17, 2018: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/30333134/diagnostic-efficacy-of-long-non-coding-rna-in-lung-cancer-a-systematic-review-and-meta-analysis
#20
Shui-Ping Dai, Jing Jin, Wei-Min Li
The detection of long non-coding RNA (lncRNA) is a novel method for lung cancer diagnosis. However, the diagnostic efficacy of lncRNA in different studies is inconsistent. Therefore, we conducted this meta-analysis to elucidate the diagnostic efficacy of lncRNA in identification of lung cancer including small cell lung cancer. The online PubMed, Medline, EMBASE, CNKI and Wanfang literature databases were searched to identify all related articles about the diagnostic efficacy of lncRNA for lung cancer. 28 articles including 3044 patients with lung cancer and 2598 controls were enrolled in our meta-analysis...
October 17, 2018: Postgraduate Medical Journal
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