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thrombosis thromboembolism thrombophilia

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https://www.readbyqxmd.com/read/30083068/thrombosis-in-children-which-test-to-whom-when-and-how-much-necessary
#1
REVIEW
Tiraje Celkan, Gürcan Dikme
Pediatric thrombosis is multifactorial, and usually risk factors either congenital or acquired are present. After 2000, systematic reviews and meta-analysis on pediatric venous thromboembolic disease and inherited thrombophilia revealed elevated thrombotic risks in these children. In this review, we discuss thrombosis and new literature in various pediatric patient groups and the usefulness of thrombophilia testing.
March 2018: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/30080915/cerebral-venous-sinus-thrombosis-in-a-child-with-idiopathic-nephrotic-syndrome-a-case-report
#2
Ana Isabel Rodrigues Silva, João Tavares, Ana Sofia Vaz, Nádia Brito, Mónica Vasconcelos, Teresa Sevivas, Lurdes Moura, Carolina Cordinhã
Complications are rare in pediatric cases of idiopathic nephrotic syndrome (NS). Thromboembolism ranks among the most uncommon and difficult complications to diagnose, particularly in the first episode of NS, since clinical signs might be unspecific. This report describes the case of a 5-year-old girl with NS for the first time presenting with severe hypoalbuminemia (< 2g/dL). The patient responded poorly to therapy with corticosteroids. On day 8 of hospitalization she started having headaches and vomiting; she did not present hemodynamic alterations, fever or exanthems, and her neurological parameters were normal...
August 2, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
https://www.readbyqxmd.com/read/30045685/hypercoagulable-states-in-arterial-and-venous-thrombosis-when-how-and-who-to-test
#3
Brett J Carroll, Gregory Piazza
Evaluation for underlying hypercoagulable states in patients with thrombosis is a frequent clinical conundrum. Testing for thrombophilias is often reflexively performed without strategic approach nor clear appreciation of the clinical implications of such results. Guidelines vary in the appropriate utilization of thrombophilia testing. In this review, we discuss the more commonly encountered inherited and acquired thrombophilias, their association with initial and recurrent venous thromboembolism, arterial thromboembolism, and role in women's health...
August 2018: Vascular Medicine
https://www.readbyqxmd.com/read/30017675/postpartum-venous-thromboembolism-readmissions-in-the-united-states
#4
Timothy Wen, Jason D Wright, Dena Goffman, Mary E D'Alton, William J Mack, Frank J Attenello, Alexander M Friedman
BACKGROUND: There are limited data on when postpartum readmissions for thromboembolism occur after delivery hospitalizations on a population basis in the United States. OBJECTIVE: We sought to characterize risk factors for and timing of postpartum venous thromboembolism readmission after delivery hospitalization discharge. STUDY DESIGN: The Healthcare Cost and Utilization Project Nationwide Readmissions Database for calendar years 2013 and 2014 was used to perform a retrospective cohort study evaluating risk for readmission for venous thromboembolism within 60 days of discharge from a delivery hospitalization...
July 11, 2018: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29949514/thromboprophylaxis-in-pregnant-women-with-thrombophilia-and-a-history-of-thrombosis
#5
Svetlana Akinshina, Alexander Makatsariya, Victoria Bitsadze, Jamilya Khizroeva, Nadine Khamani
BACKGROUND: Despite intensive research, thromboembolism still accounts for significant maternal morbidity and mortality. We examined thrombophilia in patients with thromboembolism during pregnancy and evaluated the efficiency of antithrombotic prophylaxis in patients with thrombophilia for the prevention of recurrent thromboembolism. MATERIALS AND METHODS: Sixty-eight women with a history of thromboembolism were managed during pregnancy, in light of their thrombotic history and the result of thrombophilia assessment...
June 27, 2018: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/29948593/deep-venous-thrombosis-pulmonary-embolism-and-long-distance-flights
#6
Roger W Byard
Deep vein thrombosis resulting in lethal pulmonary thromboembolism is not-infrequently encountered in forensic cases. Predisposing factors include immobility, recent surgery, previous deep venous thromboses/pulmonary thromboembolism, indwelling central venous lines, major trauma, the oral contraceptive pill, pregnancy, congenital cardiac disease, sepsis, malignancy, systemic lupus erythematosus, renal failure and certain inherited thrombophilias. Venous thrombosis associated with air travel was reported in the early 1950's and called the "economy class syndrome", although it is now recognized that reduced movement on long distance flights is more significant than seating class...
June 11, 2018: Forensic Science, Medicine, and Pathology
https://www.readbyqxmd.com/read/29945822/presence-and-degree-of-residual-venous-obstruction-on-serial-duplex-imaging-is-associated-with-increased-risk-of-recurrence-and-progression-of-infrainguinal-lower-extremity-deep-venous-thrombosis
#7
Taehwan Yoo, Rishav Aggarwal, Tzu-Fei Wang, Bhagwan Satiani, Mounir J Haurani
OBJECTIVE: The role of follow-up venous duplex ultrasound (DUS) after acute lower extremity deep vein thrombosis (DVT) remains unclear, yet it is commonly performed. We aimed to clarify the role of follow-up DUS. Our primary objective was to determine the association between the presence of residual venous obstruction (RVO) on DUS and DVT recurrence or propagation (rDVT). Secondary objectives included finding risk factors associated with RVO and rDVT. METHODS: We conducted a retrospective study of patients diagnosed with DVT on DUS from January 1, 2011, to December 31, 2013, that received a follow-up DUS...
June 23, 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29942483/triple-thrombophilic-simultaneous-mutations-in-patients-after-bariatric-surgery-is-there-a-role-for-screening-in-the-eastern-mediterranean
#8
Hussein Nassar, Ahmad Zaghal, Ali Taher, Rami Mafouz, Bassem Safadi, Mariam Kanso, Mohamad Khalife, Walid Faraj
BACKGROUND AND PURPOSE: Thrombophilia is a hypercoagulable state that predisposes to thrombosis. Several genetic risk factors have been shown to predispose to thromboembolic events. Homozygosity to a thrombophilic mutation certainly predisposes the affected patient to more serious symptoms. MATERIALS AND METHODS: Here we present a case of a 56-year-old male patient who underwent sleeve gastrectomy for morbid obesity, presenting to our institution with abdominal pain...
June 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29895622/prothrombin-conversion-is-accelerated-in-the-antiphospholipid-syndrome-and-insensitive-to-thrombomodulin
#9
Romy M W Kremers, Stéphane Zuily, Hilde Kelchtermans, Tessa C Peters, Saartje Bloemen, Véronique Regnault, H Coenraad Hemker, Philip G de Groot, Denis Wahl, Bas de Laat
Antiphospholipid syndrome (APS) is a condition in which the presence of antibodies against phospholipid-binding proteins is associated with thrombophilia and/or pregnancy morbidity. Although antiphospholipid antibodies have anticoagulant characteristics in vitro, they are associated with thromboembolic complications. Thrombin generation (TG) is a sensitive global test of coagulation, and elevated TG is associated with thrombosis. Increased TG can be caused by increased prothrombin conversion, decreased thrombin inactivation, or a combination of both...
June 12, 2018: Blood Advances
https://www.readbyqxmd.com/read/29886492/pancreatic-cancer-in-pregnancy-presenting-with-thromboembolic-events-case-report-and-review-of-the-literature
#10
Brian W Wakefield, Crystal M C Masterson, Manuel T Borges, K Joseph Hurt
Stroke and hepatic vein thrombosis are highly associated with neoplasia but are extremely rare events in young, pregnant women. Rare and recurrent thrombotic events in pregnancy increase the suspicion for occult malignancy. We describe the case of a healthy 31-year-old G2P1 who presented with visual changes and dysarthria during pregnancy. Imaging showed cerebral infarcts. Her thrombophilia evaluation was negative. During delivery, she was diagnosed with fulminant Budd-Chiari Syndrome. Hepatic ultrasound suggested malignancy or metastasis, and postpartum CT scan and biopsy confirmed the diagnosis of Stage IV pancreatic cancer...
2018: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29703491/thrombosis-in-pediatric-patients-with-leukemia
#11
Sarina Levy-Mendelovich, Assaf Arie Barg, Gili Kenet
Acute lymphoblastic leukemia (ALL) is the most common type of cancer diagnosed in children. It is reportedly the most common malignancy associated with thromboembolism in the pediatric age group. Over the last 2 decades, venous thromboembolism (VTE) has been increasingly diagnosed among pediatric ALL patients with an estimated incidence ranging from about 5% (for symptomatic cases) to about 30-70% (following sequential imaging studies in asymptomatic children). The etiology is multifactorial and may stem from alterations of the hemostatic system following various chemotherapy protocols (including use of l-Asparaginase), the presence of central venous lines (CVL), as well as comorbidities, e...
April 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29678687/clinical-characteristics-and-outcomes-of-patients-with-multiple-simultaneous-superficial-vein-thrombi
#12
Rishi Chopra, Luis R Leon, Nicos Labropoulos
BACKGROUND: Although unprovoked superficial venous thrombosis (SVT) has traditionally been considered a local, benign disorder, recent studies demonstrate that patients with SVT are at significant risk for deep venous thrombosis, pulmonary embolism, and other venous thromboembolism (VTE) events. Nevertheless, clinical management remains widely inconsistent. Moreover, patients with multiple, unprovoked SVTs of noncommunicating anatomic sites have not been previously described, and they may be at even increased risk for adverse outcomes...
July 2018: Journal of Vascular Surgery. Venous and Lymphatic Disorders
https://www.readbyqxmd.com/read/29614525/type-of-combined-contraceptives-factor-v-leiden-mutation-and-risk-of-venous-thromboembolism
#13
Justine Hugon-Rodin, Marie-Hélène Horellou, Jacqueline Conard, Anne Gompel, Geneviève Plu-Bureau
OBJECTIVE:  This article estimates the interaction between types of combined hormonal contraception (CHC) and factor V Leiden (FVL) mutation on the risk of venous thrombosis event (VTE). SUBJECTS AND METHODS:  All premenopausal women with first incident VTE who were referred to our unit (Paris, France) between 2000 and 2009 were included in this case-only study. Differences in interactions by progestin type were assessed on a multiplicative scale, assuming the independence of genotype and prescription of type of CHC...
May 2018: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29607227/rivaroxaban-treatment-for-warfarin-refractory-thrombosis-in-a-patient-with-hereditary-protein-s-deficiency
#14
Koken Ameku, Mariko Higa
Protein S (PS) deficiency, an autosomal dominant hereditary thrombophilia, is more prevalent in East Asian populations than in Caucasians. PS-deficient patients have historically been administered a heparin product followed by warfarin for the treatment and secondary prevention of venous thromboembolism (VTE). However, warfarin can be ineffective or causes detrimental effects in rare cases. While direct oral anticoagulants (DOACs) are being increasingly used for the treatment and prevention of VTE, their efficacy in PS-deficient patients has not been established...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29587641/the-prevalence-of-heterozygous-f12-mutations-in-chinese-population-and-its-relevance-to-incidents-of-thrombosis
#15
Xi Wu, Qiulan Ding, Xuefeng Wang, Jing Dai, Wenman Wu
BACKGROUND: The contribution of moderate coagulation factor XII (FXII) deficiency to development of thromboembolism is still undetermined. We have tried to show the relevance of FXII deficiency to incidences of venous thrombosis by exploring the prevalence of F12 gene mutations in Chinese patients with thrombotic disorders. METHODS: One hundred and six patients with venous thromboembolism (VTE) and 220 healthy controls were enrolled in study. The coding region and flanking sequences of F12 gene were amplified and sequenced to identify genetic variances...
March 27, 2018: BMC Medical Genetics
https://www.readbyqxmd.com/read/29576632/maternal-thrombophilia-and-recurrent-miscarriage-is-there-evidence-that-heparin-is-indicated-as-prophylaxis-against-recurrence
#16
Ana-Luisa Stefanski, Christoph Specker, Rebecca Fischer-Betz, Wolfgang Henrich, Ekkehard Schleussner, Thomas Dörner
Background: Recurrent miscarriage, also referred to as recurrent spontaneous abortion (RSA), affects 1 - 5% of couples and has a multifactorial genesis. Acquired and congenital thrombophilia have been discussed as hemostatic risk factors in the pathogenesis of RSA. Method: This review article was based on a selective search of the literature in PubMed. There was a special focus on the current body of evidence studying the association between RSA and antiphospholipid syndrome and hereditary thrombophilia disorders...
March 2018: Geburtshilfe und Frauenheilkunde
https://www.readbyqxmd.com/read/29536478/peculiar-laboratory-phenotype-genotype-relationship-due-to-compound-inherited-protein-c-defects-in-a-child-with-severe-venous-thromboembolism
#17
Cristiana Bulato, Elena Campello, Sabrina Gavasso, Sara Maggiolo, Daniela Tormene, Paolo Simioni
A 7-years-old child who developed unprovoked deep vein thrombosis (DVT) and pulmonary embolism (PE) was tested for inherited thrombophilia. Protein C (PC) antigen level (87 %) and PC coagulometric and amidolytic activities (12 % and 11 %, respectively) were consistent with a homozygous PC type IIA phenotype.The patient was carrier of two heterozygous missense mutations causing p.Arg32Cys substitution associated with a type I PC defect ("null allele", from the paternal side) and p.Gly433Ser substitution responsible for a type IIA PC defect (from the maternal side)...
February 2018: Hämostaseologie
https://www.readbyqxmd.com/read/29530427/the-association-between-otogenic-lateral-sinus-thrombosis-and-thrombophilia-a-long-term-follow-up
#18
Shay Schneider, Joseph Kapelushnik, Mordechai Kraus, Sabri El Saied, Itai Levi, Daniel Michael Kaplan
PURPOSE: Otogenic lateral sinus thrombosis (OLST) is an intracranial, potentially life-threatening complication of acute and chronic otitis media. Since congenital thrombophilic disorders are risk factors for cerebral venous thrombosis, OLST may be related to thrombophilia. The aim of our study was twofold: to evaluate whether patients who suffered from OLST in childhood also have thrombophilia, and whether these patients experienced thromboembolic episodes in future years. STUDY DESIGN: Retrospective case series...
May 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29523337/inherited-thrombophilia-and-pregnancy-loss-study-of-an-argentinian-cohort
#19
Silvia Perés Wingeyer, Federico Aranda, Sebastián Udry, José Latino, Gabriela de Larrañaga
BACKGROUND AND OBJECTIVES: Thrombophilia might increase the risk of suffering from obstetric complications by adversely affecting the normal placental vascular function. Our aim was to study the distributions of five thrombosis-associated genetic variants: factor V Leiden, prothrombin G20210A, -675 4G/5G PAI-1, 10034C/T gamma fibrinogen and 7872C/T factor XI and the frequencies of the deficiencies of protein C, S and antithrombin in Argentinian patients with recurrent pregnancy loss (RPL) and, therefore, to analyse their association with the risk and timing of RPL and the risk of suffering other vascular obstetric pathologies...
March 6, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29476267/prophylaxis-of-pulmonary-embolism-in-kidney-transplant-recipients
#20
REVIEW
Federico Cicora, Jorgelina Petroni, Javier Roberti
PURPOSE OF REVIEW: Kidney transplant recipients have an increased risk of pulmonary embolism; however, thromboprophylaxis poses a challenge as the risk of thrombosis must be balanced against the risk of bleeding. This review summarizes the evidence on whether thromboprophylaxis is required in kidney transplantation. RECENT FINDINGS: Incidence of venous thromboembolism, comprising pulmonary embolism and deep venous thrombosis, is increased in kidney transplant recipients compared to the general population, with augmented risk of death and graft loss...
February 23, 2018: Current Urology Reports
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