Matthias J P van Osch, Anders Wåhlin, Paul Scheyhing, Ingrid Mossige, Lydiane Hirschler, Anders Eklund, Klara Mogensen, Ryszard Gomolka, Alexander Radbruch, Sara Qvarlander, Andreas Decker, Maiken Nedergaard, Yuki Mori, Per Kristian Eide, Katerina Deike, Geir Ringstad
Over the last decade, it has become evident that cerebrospinal fluid (CSF) plays a pivotal role in brain solute clearance through perivascular pathways and interactions between the brain and meningeal lymphatic vessels. Whereas most of this fundamental knowledge was gained from rodent models, human brain clearance imaging has provided important insights into the human system and highlighted the existence of important interspecies differences. Current gold standard techniques for human brain clearance imaging involve the injection of gadolinium-based contrast agents and monitoring their distribution and clearance over a period from a few hours up to 2 days...
April 18, 2024: NMR in Biomedicine