Jin-Hua Liang, Wei-Ting Wang, Rong Wang, Rui Gao, Kai-Xin Du, Zi-Wen Duan, Xin-Yu Zhang, Yue Li, Jia-Zhu Wu, Hua Yin, Hao-Rui Shen, Li Wang, Jian-Yong Li, Jin-Ran Guo, Wei Xu
Mantle cell lymphoma (MCL) is an incurable and aggressive subtype of non-Hodgkin B-cell lymphoma. Increased lipid uptake, storage, and lipogenesis occur in a variety of cancers and contribute to rapid tumor growth. However, no data has been explored for the roles of lipid metabolism reprogramming in MCL. Here, we identified aberrant lipid metabolism reprogramming and PRMT5 as a key regulator of cholesterol and fatty acid metabolism reprogramming in MCL patients. High PRMT5 expression predicts adverse outcome prognosis in 105 patients with MCL and GEO database (GSE93291)...
April 12, 2024: Cancer Letters