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Living kidney

S Thukral, A Mazumdar, D S Ray
INTRODUCTION: As there is a paucity of literature regarding the long-term outcomes of complex living donors, we conducted this study to assess the effect of kidney donation on the complex living kidney donor. MATERIALS AND METHODS: This retrospective study was conducted in Narayan Health Hospital, Kolkata, Eastern India. The cohort consisted of complex living kidney donors who donated kidneys between the years 2007 and 2012. All donors were 60 years old or older, or were younger than 60 years and had comorbidities like hypertension and obesity...
June 27, 2018: Transplantation Proceedings
Mohinder R Vindhyal, Sinan Khayyat, Adnan Shaaban, Brent A Duran, K James Kallail
Introduction Heart failure (HF) is one of the most common causes of hospitalization and readmissions. Approximately six million Americans are living with HF. Among patients with HF, hospitalization rate in the United States is higher for those over age 65, making it one of the leading causes of hospitalization in this age group. Furthermore, about 15% of those who were hospitalized with HF were readmitted within 30 days and 30% within 60 days. HF and chronic kidney disease (CKD) share many risk factors; therefore, it is expected that CKD is more prevalent in HF...
August 9, 2018: Curēus
Alberto González-Almada, José M Arreola-Guerra, José Argenis López-Sánchez, Eric Cuevas, Mario Vilatoba, Alan G Contreras, Luis E Morales-Buenrostro, Josefina Alberu, Norma O Uribe-Uribe
The association between anti-AT1Rabs and microvascular injury observed in antibody-mediated rejection has been described in kidney graft Biopsies (KGBx). METHODS: We herein describe the histopathologic findings of KGBx performed during the first year of transplantation (Tx) in 134 patients tested for pre-Tx anti-AT1Rabs in cryopreserved sera (04/2009 to 09/2013). Protocol KGBx before implantation (time-zero), 1 year after Tx and for cause KGBx were included. 21/134 Tx patients were anti-AT1Rab positive (≥17 U/mL); 7/21 experienced acute rejection...
October 15, 2018: Transplant Immunology
Camilla S Hanson, Benedicte Sautenet, Jonathan C Craig, Jeremy R Chapsman, Greg Knoll, Peter P Reese, Allison Tong
BACKGROUND: Evidence about outcomes following living kidney donation is needed both to inform donor acceptance criteria, and to guide the decisions of potential donors and their healthcare providers about donation. However, the scope and heterogeneity of outcomes reported in research and their relevance to decision-making is uncertain. To determine the spectrum and consistency of outcomes reported in randomized trials and observational studies in living kidney donors aged 18 years or over...
October 17, 2018: Transplantation
Washington Rogério de Sousa, Bruno Henrique Lopes Botelho Lourenço, Michelle de Paula Reis, Guilherme Donadel, Marcia Alessandra Arantes Marques, Euclides Lara Cardozo Junior, Ezilda Jacomassi, Salviano Tramontin Belettini, Francislaine Aparecida Dos Reis Lívero, Arquimedes Gasparotto Junior, Emerson Luiz Botelho Lourenço
Yerba mate (Ilex paraguariensis A. St.-Hil.; Aquifoliaceae) is a popular tonic and stimulant beverage that is widely consumed in different South American countries. Estimates indicate the consumption of >1 L per day in southern Brazil and Uruguay. Despite its relatively high consumption, data on reproductive toxicity during critical periods of gestation remain unclear. Thus, we evaluated the effects of an aqueous extract of I. paraguariensis leaves ("chimarrão" [IPC]) at two critical periods of gestation in Wistar rats: preimplantation embryonic stage and fetal organogenesis...
October 18, 2018: Journal of Medicinal Food
Róbert Langer
The author concludes lessons learned from Hungary joining Eurotransplant five years ago through the more than half a century history of the Hungarian organ transplantation. The result of the stepwise evolution is that today's transplantation activity can be measured by a European benchmark. In comparison to the era before the membership, there are 40% more transplantations in the country. First the numbers of the living donor kidney transplantations significantly raised, followed by the organs transplanted from brain-dead donors: kidney, heart, pancreas, then liver and finally also lung...
October 2018: Orvosi Hetilap
Yuichiro Kikuchi, Ryuta Kimizuka, Tetsuo Kato, Katsuji Okuda, Eitoyo Kokubu, Kazuyuki Ishihara
Treponema denticola, an anaerobic spirochete found mainly in the oral cavity, is associated with periodontal disease and has a variety of virulence factors. Although in vitro studies have shown that T. denticola is able to penetrate epithelial cell monolayers, its effect on the epithelial barrier junction is not known. Human gingival epithelial cells are closely associated with adjacent membranes, forming barriers in the presence of tight junction proteins, including zonula occludens-1 (ZO-1), claudin-1, and occludin...
October 18, 2018: Bulletin of Tokyo Dental College
Takahiro Shinzato, Taro Kubo, Toshihiro Shimizu, Koji Nanmoku, Takashi Yagisawa
We report a 55-year-old man with a renal allograft that developed sarcoidosis. His autosomal dominant polycystic kidney disease (ADPKD) progressed to end-stage stage renal disease when he was 52 years old, and he underwent living-donor kidney transplantation at the age of 53 years. His proteinuria worsened at 19 months post-transplantation, and his renal function began to decline at 29 months post-transplantation. A renal allograft biopsy performed at 31 months post-transplantation revealed non-caseating granulomatous interstitial nephritis...
October 16, 2018: CEN Case Reports
Alexander James Hamilton, Fergus J Caskey, Anna Casula, Carol D Inward, Yoav Ben-Shlomo
BACKGROUND AND OBJECTIVES: Young adults receiving kidney replacement therapy (KRT) have impaired quality of life and may exhibit low medication adherence. We tested the hypothesis that wellbeing and medication adherence are associated with psychosocial factors. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: We conducted a cross-sectional online survey for young adults on KRT. Additional clinical information was obtained from the UK Renal Registry. We compared outcomes by treatment modality using age- and sex-adjusted regression models, having applied survey weights to account for response bias by sex, ethnicity, and socioeconomic status...
October 16, 2018: Clinical Journal of the American Society of Nephrology: CJASN
Arielle Cimeno, Jennifer Munley, Cinthia Drachenberg, Matthew Weir, Abdolreza Haririan, Jonathan Bromberg, Rolf N Barth, Joseph R Scalea
BACKGROUND: Patients with type II diabetes mellitus (DM) undergoing renal transplantation are at risk of diabetic nephropathy (DN) in the transplanted kidney. The true risk of developing post-transplantation DN is unknown, and post-transplantation DN is poorly characterized in the literature. METHODS: The biopsy database at the University of Maryland Medical Center was queried for kidney transplant biopsies which demonstrated evidence of DN. The time from transplantation to biopsy-proven DN (time to diagnosis, TTD) was calculated and analyzed in the context of demographics, serum creatinine, and onset of diabetes...
October 16, 2018: Clinical Transplantation
Christopher E Forsmark, Dana K Andersen, John T Farrar, Megan Golden, Aida Habtezion, Sohail Z Husain, Liang Li, Julia Mayerle, Stephen J Pandol, Aliye Uc, Zixi Zhu, Dhiraj Yadav
The lack of effective therapeutic agents specifically tailored for chronic pancreatitis (CP) has hampered clinical care and negatively impacted patients' lives. New mechanistic insights now point to novel therapies, which involve both recently developed and/or repurposed agents. This working group focused on 2 main outcomes for CP: pain and progression of disease. The goal is to frame the essential aspects of trial design including patient-centered outcomes, proposed methods to measure the outcomes of pain and progression, and study design considerations for future trials to facilitate rapid drug development for patients with CP...
November 2018: Pancreas
Hayet Kaaroud, Amel Harzallah, Mariem Najjar, Nour Houda Chtioui, Mohamed Cherif, Haroun Ayed, W Kerkeni, A Bouzouita, M Chebil, Emna Talbi, Hanene Baccouch, Amal Benzarti, Jaouida Abdelmoula, Fethi Benhamida, Taieb Ben Abdallah
BACKGROUND: Living kidney donation for transplantation has become common practice. The decisions to accept a donor with nephrolithiasis are becoming frequent. AIM: The aim of our study was to report our experience in the living donor kidney with asymptomatic lithiasis. METHODS: Over a period of 4 years from 2009 to 2013 we collected 18 cases. From the clinical, metabolic and radiological data, we have determined the etiology of urolithiasis in our patients and established, after a literature review, a decision tree of kidney donation...
February 2018: La Tunisie Médicale
Lucas De Lavallaz, Carlos G Musso
INTRODUCTION: Chronobiology studies the phenomenon of rhythmicity in living organisms. The circadian rhythms are genetically determined and regulated by external synchronizers (the daylight cycle). Several biological processes involved in the pharmacokinetics and pharmacodynamics of drugs are subjected to circadian variations. Chronopharmacology studies how biological rhythms influence pharmacokinetics, pharmacodynamics, and toxicity, and determines whether time-of-day administration modifies the pharmacological characteristics of the drug...
October 15, 2018: International Urology and Nephrology
Leena R Yeolekar, Milan Ganguly, Parikshit Tyagi, Nilesh B Ingle, Koert J Stittelaar, Leon de Waal, Francesco Berlanda Scorza, Kutub Mahmood, Rajeev M Dhere
A ferret challenge study was conducted to address the efficacy of the egg-based and Madin-Darby canine kidney (MDCK)-based live attenuated influenza vaccine (LAIV) strains. Vaccines derived as 6:2 reassortants from the A/Leningrad/134/17/57 master donor strain and the HA and NA components from the A/California/07/2009 (A/Cal)- and A/Michigan/45/2015 (A/Mich)-like strains of type A H1N1 influenza virus were used in the study. Monovalent, trivalent and quadrivalent formulations of the LAIV containing either of the two H1N1 strains were analysed...
October 12, 2018: Vaccine
Supa Pengpid, Karl Peltzer
Background: Quality of life is a key measure in estimating the burden of disease, especially of chronic diseases. This study investigated the impact of a variety of chronic diseases on quality of life (QoL) in primary health care patients in three Southeast Asian countries (Cambodia, Myanmar, and Vietnam). Methods: This cross-sectional survey was conducted on 4803 adult chronic disease patients (mean age 49.3 yr; SD=16.5) recruited systematically from primary health care centers in rural and urban areas in Cambodia, Myanmar and Vietnam in 2015...
September 2018: Iranian Journal of Public Health
Masayoshi Okumi, Kohei Unagami, Miyuki Furusawa, Yoichi Kakuta, Junpei IIzuka, Toshio Takagi, Hiroki Shirakawa, Tomokazu Shimizu, Kazuya Omoto, Masashi Inui, Hideki Ishida, Kazunari Tanabe
Tacrolimus (TAC) is available as a twice-daily capsule (TAC-BID), once-daily capsule (TAC-QD), and once-daily tablet. Recipients with ABO-incompatible/anti-human leukocyte antigen (HLA)-incompatible transplantation were excluded in previous trials and have thus not been evaluated. We conducted a 5-year trial to determine whether TAC-QD is noninferior to TAC-BID for transplant outcomes. Adults who underwent de novo living kidney transplantation were randomly assigned (62 TAC-QD; 63 TAC-BID). We did not exclude ABO-/HLA- incompatible transplantation...
October 14, 2018: Clinical Transplantation
Nassreen Abdullah, Niall F Davis, John Quinn, Ponnusamy Mohan
Hermansky-Pudlak syndrome (HPS) is a rare genetic disorder characterised by oculocutaneous albinism, bleeding diathesis and end-stage renal disease (ESRD), due to interstitial deposition of ceroid lipofuscin. Renal transplantation is potentially a definitive treatment option for patients with ESRD due to HPS. Herein, we describe the case of a 55-year-old male patient with HPS that successfully underwent a living donor kidney transplant. We also emphasise the importance of multidisciplinary input during the preoperative, perioperative and postoperative phases in this high-risk clinical scenario...
October 12, 2018: BMJ Case Reports
T Martin, K Mantey, R Boissier, P Albert, V Grisoni, E Lechevallier, D Barriol, G Gravis, G Pignot, D Rossi, J Lorca, C Rattier, C Eghazarian, N Daou, J L Davin, C Clément, A Akiki, L Pascal, G Karsenty
INTRODUCTION: The REVELA13 observatory is a unique epidemiological tool listing the new cases of kidney tumors, bladder tumors and acute leukaemias in the Bouches-du-Rhône county (France). Aim was to exploit for the first time data from this observatory regarding new cases of bladder tumors≥T1 in women from 2012 to 2014. MATERIALS: This epidemiological study was observational and descriptive. Fifteen non-nominative variables from the REVELA13 database were analyzed in order to describe the clinical and pathological characteristics of the incident cases as well as their spatial and temporal distribution...
October 10, 2018: Progrès en Urologie
S Tatarano, H Enokida, Y Yamada, H Nishimura, M Nakagawa
Living kidney donor guidelines recommend that donors in whom a malignancy is diagnosed should be excluded. Although preoperative screening for malignancies was performed, we experienced a case of living donor with small lymphocytic lymphoma (SLL) at the time of donation. A 53-year-old woman was referred to our hospital for a kidney donation to her son. She had no past medical history of malignancy. We screened the patient using medical examinations, but there was no obvious presence of malignancy. Although preoperative computed tomography showed a small lymph node swelling at the left renal hilum, we diagnosed it as an insignificant lymph node...
October 2018: Transplantation Proceedings
H Hirano, R Maenosono, T Matsunaga, H Uehara, H Nomi, A Ichihashi, D Kobayashi, S Taniguchi, T Tsutsumi, T Tsujino, K Komura, N Ibuki, T Inamoto, H Azuma
Much controversy exists over the performance of elderly living donor kidney transplantation. We report the safety of 2 cases of elderly living kidney donations in our hospital. CASE 1: An 82-year-old man was a living kidney donor for his 56-year-old son. The donor suffered from hypertension, but has successfully managed his blood pressure with only one medication. His serum creatinine was 0.7 mg/dL and inulin clearance was 122.5 mL/min, which met the usual criteria for living kidney donors. This was his son's secondary kidney transplantation, and no other donors existed...
October 2018: Transplantation Proceedings
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