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Living kidney

Tamar A J van den Berg, Robert C Minnee, Ton Lisman, Gertrude J Nieuwenhuijs-Moeke, Jacqueline van de Wetering, Stephan J L Bakker, Robert A Pol
Perioperative antithrombotic therapy could play a role in preventing thromboembolic complications (TEC) after kidney transplantation (KTx), but little is known on postoperative bleeding risks. This retrospective analysis comprises 2000 single-organ KTx recipients transplanted between 2011-2016 in the two largest transplant centers of the Netherlands. TEC and bleeding events were scored ≤7 days post-KTx. Primary analyses were for associations of antithrombotic therapy with incidence of TEC and bleeding. Secondary analyses were for associations of other potential risk factors...
December 10, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
Claudiu Marginean, Vladut Sasarean, Cristina Oana Marginean, Lorena Elena Melit, Maria Oana Marginean
AIM: Orofacial clefts comprise cleft lip (CL) or cleft lip-palate (CLP) and are the most frequently encountered malformation of the facial region, accounting for approximately 1-2.2/1,000 live births. The aim of this study was to reveal the particularities regarding the prenatal diagnosis of orofacial clefts in a series of 11 cases diagnosed in a tertiary center.Material and methods: The study was performed in a tertiary diagnostic center for a period of 8 years (January 2010 - December 2017), on8125 patients that were assessed for screening or suspicion of malformations...
December 8, 2018: Medical Ultrasonography
Vasishta S Tatapudi, David S Goldfarb
PURPOSE OF REVIEW: Traditionally, nephrolithiasis was considered a relative contraindication to kidney donation because of a risk of recurrent stones in donors and adverse stone-related outcomes in recipients. However, the scarcity of organs has driven the transplant community to re-examine and broaden selection criteria for living donors with stones. In this review, we summarize and contrast the guidelines published by various prominent national and international societies on this topic...
December 5, 2018: Current Opinion in Nephrology and Hypertension
Yu Liang Liu, Hao-Lun Luo, Po-Huang Chiang, Yen-Chen Chang, Po-Hui Chiang
OBJECTIVE: Ileal conduit urinary diversion (ICUD) is the most common procedure after radical cystectomy. Although complications have been reported, few patients with ICUD and bladder preservation controls have been available for long-term follow-up. This study compared the long-term effect of structural changes after cystectomy with ICUD to that in bladder preservation controls. DESIGN: A retrospective nationwide cohort study. SETTING: Data retrieved from the Taiwan National Health Insurance Research Database...
December 9, 2018: BMJ Open
Andreas D Flouris, Petros C Dinas, Leonidas G Ioannou, Lars Nybo, George Havenith, Glen P Kenny, Tord Kjellstrom
BACKGROUND: Occupational heat strain (ie, the effect of environmental heat stress on the body) directly threatens workers' ability to live healthy and productive lives. We estimated the effects of occupational heat strain on workers' health and productivity outcomes. METHODS: Following PRISMA guidelines for this systematic review and meta-analysis, we searched PubMed and Embase from database inception to Feb 5, 2018, for relevant studies in any labour environment and at any level of occupational heat strain...
December 2018: The Lancet. Planetary health
Andrew T Olagunju, Babatunde Fadipe, Rotimi W Buraimoh, Olagoke K Ale, Theophilus I Umeizudike, Raphael E Ogbolu, Nasur Buyinza, Jonathan Bayuo, Barbara Mutedzi, Kennedy Nkhoma, Eve Namisango, Katherine Bristowe, Deokhee Yi, Julia Downing, Olatunji F Aina, Joseph D Adeyemi, Fliss E M Murtagh, Richard Harding
BACKGROUND: The burden of symptoms and other concerns in chronic kidney disease (CKD) is known to be high, adversely affecting the quality of life of the growing number of those with this condition in developing countries. In this paper, we describe the protocol of a longitudinal observational study among people living with CKD. The study is developed to assess the bio-psychosocial factors associated with palliative care symptoms and concerns, and pattern of health services usage among Nigerians with stages 3-5 CKD...
October 17, 2018: Annals of Palliative Medicine
David P Al-Adra, Maria Lambadaris, Andrew Barbas, Yanhong Li, Markus Selzner, Sunita K Singh, Olusegun Famure, S Joseph Kim, Anand Ghanekar
PURPOSE: The effect of living donor kidney allograft size on recipient outcomes is not well understood. In this study, we sought to investigate the relationship between preoperatively measured donor kidney volume and recipient estimated glomerular filtration rate (eGFR) in living donor kidney transplantation (LDKT). METHODS: We studied computed tomography (CT) donor kidney volumes and recipient outcomes for 438 LDKTs at the Toronto General Hospital between 2007 and 2016...
December 6, 2018: World Journal of Urology
C-E Hsieh, Y Yang, K-H Lin, C-C Chen, C-J Ko, Y-L Hsu, C-C Lin, Y-J Hung, P-Y Lin, S-H Wang, Y-L Chen
We present a patient with positive donor-specific antibodies (DSA) and crossmatch of ABO-incompatible (ABOi) combined liver and kidney transplantation (CLKT). Antibody-mediated rejection did not occur and the graft had survived for over one year at the time of writing without infectious complications. A 56-year-old man with positive DSA and positive crossmatch underwent living donor CLKT. The preoperative protocol for ABOi consisted of a single dose of rituximab and total plasma exchange (TPE). The result of anti-B antibody titer for IgG was 1:32...
May 29, 2018: Transplantation Proceedings
Kabir O Olaniran, Nwamaka D Eneanya, Sagar U Nigwekar, Xavier F Vela-Parada, Maureen M Achebe, Amita Sharma, Ravi I Thadhani
BACKGROUND: Compared to the past, patients with sickle cell disease (SCD) currently live longer due to improvements in diagnosis and comprehensive care. Due to these advances, long-term chronic complications pose a greater challenge in the management of patients with SCD. In particular, sickle cell nephropathy (SCN) is associated with significant morbidity and mortality across all age groups. Furthermore, SCN is an understudied condition with relatively few symptoms and therefore requires close surveillance...
December 5, 2018: Blood Purification
Lori L O'Brien, Alexander N Combes, Kieran M Short, Nils O Lindström, Peter H Whitney, Luise A Cullen-McEwen, Adler Ju, Ahmed Abdelhalim, Odyssé Michos, John F Bertram, Ian M Smyth, Melissa H Little, Andrew P McMahon
A normal endowment of nephrons in the mammalian kidney requires a balance of nephron progenitor self-renewal and differentiation throughout development. Here, we provide evidence for a novel action of ureteric branch tip-derived Wnt11 in progenitor cell organization and interactions within the nephrogenic niche, ultimately determining nephron endowment. In Wnt11 mutants, nephron progenitors dispersed from their restricted niche, intermixing with interstitial progenitors. Nephron progenitor differentiation was accelerated, kidneys were significantly smaller, and the nephron progenitor pool was prematurely exhausted, halving the final nephron count...
December 5, 2018: ELife
Min Li, Hua Zhou, Min Yang, Changying Xing
PURPOSE: Vascular calcification (VC) is known to be prevalent in patients with end-stage renal disease (ESRD). Sclerostin has been identified to be involved in the cross-talk between the kidney, vasculature, and bone. The aims of the present study were to evaluate vessel sclerostin expression and its correlation with VC, as well as serum sclerostin levels. METHODS: A total of 51 adult ESRD patients undergoing living donor renal transplant (RT) were enrolled in this study...
December 4, 2018: International Urology and Nephrology
Hui Yang, Libo Du, Guangjun Wu, Zhenyu Wu, Jeffrey A Keelan
BACKGROUND: Gold nanoparticles (AuNPs) have been widely studied for biomedical applications, although their safety and potential toxicity in pregnancy remains unknown. The aim of this study is to explore the effect of AuNPs maternal exposure at different gestational ages on fetal survival and development, as well as the potential mechanism of AuNPs affecting embryos and fetuses. METHODS: Thirty nm polyethylene glycol (PEG)-coated AuNPs (A30) were administered to pregnant mice via intravenous injection (5 μg Au/g body weight) over three days at either early or late pregnancy...
December 3, 2018: Molecular Medicine
Peter W Schreiber, Verena Kufner, Kerstin Hübel, Stefan Schmutz, Osvaldo Zagordi, Amandeep Kaur, Cornelia Bayard, Michael Greiner, Andrea Zbinden, Riccarda Capaul, Jürg Böni, Hans H Hirsch, Thomas F Mueller, Nicolas J Mueller, Alexandra Trkola, Michael Huber
Background: Before kidney transplantation, donors and recipients are routinely screened for viral pathogens using specific tests. Little is known about unrecognized viruses of the urinary tract that potentially result in transmission. Using an open metagenomic approach, we aimed to comprehensively assess virus transmission in living donor kidney transplantation. Methods: Living kidney donors and their corresponding recipients were enrolled at the time of transplantation...
December 2, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
Portia Ritter, Keyvan Yousefi, Juliana Ramirez, Derek M Dykxhoorn, Armando J Mendez, Lina A Shehadeh
The regulation of LDL cholesterol uptake through LDLR-mediated endocytosis is an important area of study in various major pathologies including metabolic disorder, cardiovascular disease, and kidney disease. Currently, there is no available method to assess LDL uptake while simultaneously monitoring for health of the cells. The current study presents a protocol, using a live cell imaging analysis system, to acquire serial measurements of LDL influx with concurrent monitoring for cell health. This novel technique is tested in three human cell lines (hepatic, renal tubular epithelial, and coronary artery endothelial cells) over a four-hour time course...
November 17, 2018: Journal of Visualized Experiments: JoVE
Alberto Ortiz, Maria Dolores Sanchez-Niño, Marta Crespo-Barrio, Patricia De-Sequera-Ortiz, Elvira Fernández-Giráldez, Rafael García-Maset, Manuel Macía-Heras, Miguel Pérez-Fontán, Mariano Rodríguez-Portillo, Mercedes Salgueira-Lazo, Emilio Sánchez-Álvarez, Rafael Santamaría-Olmo, Fernando Simal-Blanco, Maria Dolores Pino-Pino
The Global Burden of Disease (GBD) study measures the health of populations worldwide and by country on an annual basis and aims at helping guide public policy on health issues. The GBD estimates for Spain in 2016 and recent trends in mortality and morbidity from 2006 to 2016 were recently published. According to these estimates, chronic kidney disease was the 8th cause of death in Spain in 2016. Among the top ten causes of death, chronic kidney disease was the fastest growing from 2006 to 2016, after Alzheimer disease...
November 28, 2018: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
Rasha Kamal Abouelenein, Ayman Fathi Refaie, Yaser A Alhendy, Amir M Al Okily, Nabil Abdelfadil Elserwy, Mohamed Elsayed Mashaly, Mohamed Hamed Abbas, Mohamed Adel Bakr
OBJECTIVES: The goal when treating patients with end-stage renal disease is to increase patient survival and to provide a better quality of life, both of which can be achieved by kidney transplant. Identifying problems associated with kidney transplant is an essential step toward improved graft function. Here, we evaluated posttransplant erythrocytosis, a frequent complication among kidney transplant recipients. MATERIALS AND METHODS: In this single-center retro-spective study, we identified 1850 kidney transplant recipients who were transplanted at the Mansoura Urology and Nephrology Center (Mansoura University, Mansoura, Egypt) from 1990 and 2013...
November 28, 2018: Experimental and Clinical Transplantation
Steven Habbous, Justin Woo, Ngan N Lam, Krista L Lentine, Matthew Cooper, Marian Reich, Amit X Garg
Introduction: The process of evaluating candidates for living kidney donation can be inefficient. A structured review of existing information on this topic can provide a necessary foundation for quality improvement. Methods: We conducted a scoping review to map the published literature to different themes related to an efficient donor candidate evaluation. We reviewed the websites of living donor programs to describe information provided to candidates about the nature and length of the evaluation process...
October 2018: Transplantation Direct
Carlos Angulo, Veronica Sanchez, Karen Delgado, Martha Reyes-Becerril
C-type lectins are a principal carbohydrate recognition mechanism as glucans on cell surfaces. This study identified and investigated molecular characterization and immune roles of a novel c-type lectin 17A from Totoaba macdonaldi (TmCLEC17A), which were described in head-kidney leukocytes after immunostimulation with fungal β-glucan 197A and Vibrio parahaemolyticus infection. This nucleotide sequence from totoaba was acquired using NGS and bioinformatics tools. Its full-length cDNA sequence consisted of 1128 bp (including the stop codon) and an open reading frame (ORF) of 771 bp encoding a 256 amino acid protein, 5´-UTR of 48 bp and 3´-UTR of 309 bp...
October 18, 2018: Immunobiology
Hyun Yong Lee, Young Nam Roh, Hyoung Tae Kim, Ui Jun Park
Late occurrence of arterial aneurysms following ligation of a hemodialysis arteriovenous fistula (AVF) is rare. Here, we report the case of 51-year-old male patient with an AVF in which arterial aneurysms developed. The patient had undergone left arm radiocephalic (RC) AVF creation for hemodialysis in 2000. He had received a living related donor kidney transplantation from his father in the same year. His RC AVF was ligated in 2009. However, his arm continued to gradually grow in size even after ligation and he visited a hospital for acute pain and erythema around the left elbow in 2017...
November 28, 2018: Vascular and Endovascular Surgery
Philip J Held, Frank McCormick, Glenn M Chertow, Thomas G Peters, John P Roberts
Government compensation of kidney donors would likely increase the supply of kidneys and prevent the premature deaths of tens of thousands of patients with kidney failure each year. The major argument against it is that it would exploit the poor who would be more likely to accept the offers of compensation. This overlooks the fact that many poor patients desperately need a kidney transplant and would greatly benefit from an increased supply of kidneys. The objective of this study is to empirically test the hypothesis that government compensation of kidney donors would exploit the poor...
2018: PloS One
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