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Living kidney

N Ziklo, A Colorni, L-Y Gao, S J Du, M Ucko
No vaccine is yet commercially available against Mycobacterium marinum, the etiological agent of "fish tuberculosis". The mycobacterial gene responsible for invasion and intracellular persistence, iipA, is known to moderate M. marinum pathology in zebrafish. Two doses of heat-killed, wild type virulent M. marinum and two doses of a heat-killed avirulent M. marinum iipA::kan mutant strain were used in parallel to vaccinate sea bass (Dicentrarchus labrax). The fish were then challenged with live virulent M...
August 18, 2018: Journal of Aquatic Animal Health
Damien C O'Neill, Niall F Davis, Timothy É Murray, Michael J Lee, Dilly Little, Martina M Morrin
OBJECTIVES: Prospective renal donors are a select population of healthy individuals who have been thoroughly screened for significant comorbidities before they undergo multidetector computed tomography. Our aim was to determine the prevalence of incidental findings on preoperative multidetector computed tomography in a healthy cohort of potential living donors for kidney transplant. MATERIALS AND METHODS: A prospective study was performed of prospective living kidney transplant donors at a national kidney transplant center...
August 17, 2018: Experimental and Clinical Transplantation
Andriy V Trailin, Tamara N Nykonenko, Tetyana I Ostapenko, Sergiy R Vildanov, Olexandr S Nykonenko
OBJECTIVES: Our aim was to evaluate which histologic lesions in a donor kidney were associated with graft function up to 5 years and with its dynamics. MATERIALS AND METHODS: We retrospectively investigated the association between acute and chronic individual histologic lesions and composite scores in preimplant and postreperfusion biopsies from deceased-donor (n = 101) and living-donor (n = 29) kidneys with initial graft function and function at discharge, at 6 months, and at 5 years and slopes of estimated glomerular filtration rate from discharge to 6 months and from 6 months to 5 years...
August 17, 2018: Experimental and Clinical Transplantation
Yasuko Nagasaka, Bernadette O Fernandez, Andrea U Steinbicker, Ester Spagnolli, Rajeev Malhotra, Donald B Bloch, Kenneth D Bloch, Warren M Zapol, Martin Feelisch
BACKGROUND: Endogenous nitric oxide (NO) may contribute to ischemic and anesthetic preconditioning while exogenous NO protects against ischemia-reperfusion (I/R) injury in the heart and other organs. Why those beneficial effects observed in animal models do not always translate into clinical effectiveness remains unclear. To mitigate reperfusion damage a source of NO is required. NO inhalation is known to increase tissue NO metabolites, but little information exists about the lifetime of these species...
August 13, 2018: Nitric Oxide: Biology and Chemistry
Claudia Andrea Ramírez-Perdomo, Mari Carmen Solano-Ruíz
OBJECTIVE: To understand the experience of people living with Chronic Kidney Disease who have been transplanted, from the meanings constructed based on the experienced phenomenon. METHOD: Hermeneutic-phenomenological study based on the five lifeworld existentials, according to Van Manen's theoretical framework. Eleven transplanted patients participated in the study and data collection was carried out through semi-structured interviews, after approval of the study by the Ethics Committee of the University of Antioquia...
August 9, 2018: Revista Latino-americana de Enfermagem
Prashant Joshi, Vinay R Sonawane, Ibidapo S Williams, Glen J P McCann, Linda Gatchie, Rajni Sharma, Naresh Satti, Bhabatosh Chaudhuri, Sandip B Bharate
CYP1A1 is thought to mediate carcinogenesis in oral, lung and epithelial cancers. In order to identify a CYP1A1 inhibitor from an edible plant, 394 natural products in the IIIM's natural product repository were screened, at 10 μM concentration, using CYP1A1-Sacchrosomes™ ( i.e. microsomal enzyme isolated from recombinant baker's yeast). Twenty-seven natural products were identified that inhibited 40-97% of CYP1A1's 7-ethoxyresorufin- O -deethylase activity. The IC50 values of the 'hits', belonging to different chemical scaffolds, were determined...
February 1, 2018: MedChemComm
Milton Halyson Benevides de Freitas, Luciana Cavalcanti Lima, Tania Cursino de Menezes Couceiro, Wilton Bernadino da Silva, João Marcelo de Andrade, Marcio Handerson Benevides de Freitas
INTRODUCTION: Successful renal transplant and consequent good graft function depend on a good surgical technique, an anesthetic that ensures the hemodynamic stability of the receiver, and appropriate conditions of graft and recipient. Several factors can interfere with the perfusion of the graft and compromise its viability. The objective of this study was to evaluate perioperative factors associated with delayed graft function (DGF) in renal transplantation patients. METHODS: This is a historical cohort study of patients who underwent renal transplantation between 2011 and 2013...
August 13, 2018: Jornal Brasileiro de Nefrologia: ʹorgão Oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
Natesan Anand Vijai, Palanisamy Senthilnathan, Vikram Annamaneni, Sandeep C Sabnis, Arvinder Singh Soin, Chinnusamy Palanivelu
Liver transplantation is a ray of hope for thousands of patients with end-stage liver disease but is currently challenged by the scarcity of donor organs worldwide. Unlike kidney transplantation where minimally invasive donor organ procurement has almost become a norm, laparoscopic procurement of hemi-liver from a living donor is still in the infancy of development, at least in the Indian sub-continent. Minimally invasive surgery has made its way into different procedures of hepatobiliary and pancreatic surgery, but only a few centres in the world are performing pure laparoscopic donor hepatectomy...
August 7, 2018: Journal of Minimal Access Surgery
Elena Bruzzesi, Irini Sereti
The introduction of combination antiretroviral therapy (cART) in the 1990s has dramatically changed the course of HIV infection, decreasing the risk for both AIDS- and non-AIDS-related events. Cancers, cardiovascular disease (CVD), liver and kidney disease, neurological disorders and frailty have become of great importance lately in the clinical management as they represent the principal cause of death in people living with HIV who receive cART (Kirk et al. in Clin Infect Dis 45(1):103-10, 2007; Strategies for Management of Antiretroviral Therapy Study et al...
August 14, 2018: Current Topics in Microbiology and Immunology
Tapas Kumar Singh, Sandeep Sahu, Anil Agarwal, Devendra Gupta, Prabhaker Mishra
Background and Aims: Catheter-related bladder discomfort (CRBD) has started to gain recognition as a problem in early postoperative care. Dexmedetomidine reduces bladder contractility via M3 muscarinic receptor antagonism and α-2 receptor agonism, apart from its concomitant therapeutic benefits, such as sedation and sympatholysis, in a postoperative period. We, therefore, evaluated the efficacy of dexmedetomidine in reducing incidence and severity of CRBD. Material and Methods: This prospective, randomized, double-blind, placebo-controlled trial done on 110 voluntary kidney donors for live related kidney transplantations were planned for laparoscopic donor nephrectomy...
April 2018: Journal of Anaesthesiology, Clinical Pharmacology
J W Lee, T A Woyengo
Oilseed cakes have high oil content, and thus their inclusion in swine can lead to reduced dietary inclusion of oil, and hence reduced cost of feed. An experiment was conducted to determine effects of including Brassica napus-derived cold-pressed canola cake (CPCC) in diets for nursery pigs on growth performance, organ weights relative to live body weight (BW), and blood parameters. A total of 160 pigs (initial BW: 7.8 ± 0.9 kg), which had been weaned at 21 d of age were housed in 40 pens (4 pigs/pen) and fed 4 diets (10 pens/diet) in a randomized complete block design for 35 d...
August 9, 2018: Journal of Animal Science
Jennifer C Gander, Xingyu Zhang, Laura Plantinga, Sudeshna Paul, Mohua Basu, Stephen O Pastan, Eric Gibney, Erica Hartmann, Laura Mulloy, Carlos Zayas, Rachel E Patzer
BACKGROUND: Racial disparities persist in access to kidney transplantation. Racial differences in preemptive referral, or referral prior to dialysis start, may explain this discrepancy. METHODS: Patient-level data on kidney transplant referrals (2005-2012) from all Georgia transplant centers were linked to the United States Renal Data System to examine racial disparities in preemptive referral, waitlisting, and living donor transplant. Adjusted logistic regression and Cox proportional hazard models determined the associations between race (African American vs...
August 12, 2018: Clinical Transplantation
Monika Szpotanska-Sikorska, Natalia Mazanowska, Anna Madej, Bozena Kociszewska-Najman, Miroslaw Wielgos, Bronislawa Pietrzak
INTRODUCTION: To estimate reproductive life planning in post-transplant women and to identify factors affecting their pregnancy intentions. MATERIAL AND METHODS: A survey study on reproductive life planning was conducted in 217 women of childbearing age who underwent kidney or liver transplantation. The results were compared with data obtained from 816 healthy women surveyed by the Polish Centre for Public Opinion Research. Data were summarized using descriptive statistics...
August 11, 2018: Clinical Transplantation
Sameera Senanayake, Nalika Gunawardena, Paba Palihawadana, Chathurie Suraweera, R Karunarathna, Priyantha Kumara
OBJECTIVE: Chronic Kidney Disease (CKD) is known to adversely affect mental health. The study was aimed at estimating the prevalence of depression and psychological distress and the associated factors among CKD patients living in Anuradhapura, a rural district in Sri Lanka. METHOD: A community-based, cross-sectional study included a representative sample of 1174 CKD patients, drawn proportionately from all registered patients in all 19 Medical Officer of Health areas in the district of Anuradhapura...
September 2018: Journal of Psychosomatic Research
Adela Urisarri, Marta Gil, Natalia Mandiá, Luís Aldamiz-Echevarría, Roca Iria, Domingo González-Lamuño, María-Luz Couce
To evaluate the prognostic significance of factors frequently associated with a reduction in renal mass, such as prematurity, low birth weight, and congenital anomalies of kidney and urinary tract (CAKUT), in patients with solitary functioning kidney (SFK) and investigate signs of early renal injury due to glomerular hyperfiltration damage or dysplasia in the remaining kidney.Retrospective observational study of congenital SFK diagnosed and followed at a tertiary care hospital over a period of 10 years in which 32,900 newborns underwent routine neonatal abdominal ultrasound screening...
August 2018: Medicine (Baltimore)
Rui Zhan, Yan-Qing Li, Chun-Yan Chen, Han-Yu Hu, Chun Zhang
RATIONALE: Epithelioid angiomyolipoma (EAML) is a subtype of angiomyolipoma with malignant potential. A diagnosis of malignant EAML of the kidney is based on extrarenal metastasis, and predicting early transformation is difficult. To propose criteria for indicators of malignant transformation, herein we report 2 cases and review 17 cases reported in the literature (2000-2017). PATIENT CONCERNS: Tumor of the kidney was determined in 2 patients, and tissues after nephrectomy were pathologically, histologically, and immunochemically examined...
August 2018: Medicine (Baltimore)
Graziano Vignolini, Francesco Sessa, Isabella Greco, Alessandro Pili, Saverio Giancane, Arcangelo Sebastianelli, Giampaolo Siena, Mauro Gacci, Vincenzo Li Marzi, Riccardo Campi, Sergio Serni
Background: Autosomal dominant polycystic kidney disease (ADPKD) is a common cause of end-stage renal disease (ESRD) and may pose significant technical challenges for kidney transplantation. Recently, robot-assisted kidney transplantation (RAKT) has been shown to achieve excellent patient and graft outcomes while reducing surgical morbidity. However, the vast majority of RAKT performed so far were from living donors and no studies reported the outcomes of RAKT in patients with ADPKD. Case Presentation: Herein, we describe the first successful case of RAKT from a brain-dead deceased donor in a 37-year-old patient with ESRD due to ADPKD...
2018: Journal of Endourology Case Reports
Eric P Zhou, Elizabeth Kiwanuka, Paul E Morrissey
Background: The Internet has extensive resources for kidney transplantation recipients. Half of the population reads below a seventh-grade level. Previous studies showed that living donor recipients have higher health literacy rates compared with deceased donor recipients. There has been no study comparing the readability of online living donor recipient materials versus deceased donor recipient materials. Methods: Analysis was performed using eight readability scales on the top 10 websites for live donor and deceased donor kidney transplantation...
August 2018: Clinical Kidney Journal
Wida S Cherikh, Linda C Cendales, Christopher L Wholley, Jennifer Wainright, Vijay S Gorantla, David K Klassen, Sue McDiarmid, L Scott Levin
On July 3, 2014, the Organ Procurement and Transplantation Network/United Network for Organ Sharing was charged with the oversight of Vascularized Composite Allograft (VCA) procurement and transplantation in the U.S. As of December 31, 2017, 61 VCA programs at 27 centers were approved in the U.S. Fifty candidates have been added to the waiting list at 15 centers. Twenty-eight VCA transplants have been performed at 14 programs (10 upper limb, 10 uterus, 5 craniofacial, 1 scalp, 1 abdominal wall, and 1 penile)...
August 9, 2018: American Journal of Transplantation
Adi Drori, Anna Permyakova, Rivka Hadar, Shiran Udi, Alina Nemirovski, Joseph Tam
AIMS: To evaluate the specific role of the endocannabinoid/CB1 R system in modulating mitochondrial dynamics in the metabolically active renal proximal tubular cells (RPTCs). MATERIALS AND METHODS: We utilized mitochondrialy-targeted GFP in live cells (wild-type and null for the CB1 R), and electron microscopy in kidney sections of RPTC-CB1 R-/- mice and their littermate controls. In both in vitro and in vivo conditions, we assessed the ability of CB1 R agonism or fatty acid flux to modulate mitochondrial architecture and function...
August 9, 2018: Diabetes, Obesity & Metabolism
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