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Colorectal Cancer Metastasis

Zhaoting Yang, Chengye Zhang, Wenbo Qi, Yanhua Xuan, Yan Cui
The role of Hedgehog (HH)/ glioma-associated oncogene homolog 1 (GLI1) pathway has been implicated in a variety of cancer entities, and the targeted pathway inhibition mediated by GLI1 is of therapeutic relevance. However, its oncogenicity and cross-talks with other cancer pathways including PI3K/Akt/NFκB, which modulates the HH/GLI1 signal strength, have rarely been explored in colorectal adenocarcinoma. We assessed the expression of GLI1 and its relationship with other cancer stemness genes, cell cycle markers, epithelial-mesenchymal transition (EMT), PI3K/Akt/NFκB signaling pathway genes, and HIF1α in 100 paraffin-embedded colorectal adenocarcinoma tissue samples using immunohistochemistry...
October 12, 2018: Experimental Cell Research
Li Liu, Huan Liu, Yangying Zhou, Jiaofeng He, Qiong Liu, Jian Wang, Manting Zeng, Dan Yuan, Fengbo Tan, Yuan Zhou, Haiping Pei, Hong Zhu
Helicase‑like transcription factor (HLTF) has been identified as a tumor suppressor gene. The hypermethylation of HTLF is frequently observed in various types of cancer, including colorectal cancer (CRC). However, the mechanisms through which HLTF suppresses CRC progression remain unclear. Thus, the aim of the present study was to explore the biological function of HLTF in CRC cells and the underlying mechanisms. CRC tissues and cells were used to detect the expression of HLTF. Wound‑healing and Transwell assays were performed to assess the motility of CRC cells...
October 10, 2018: International Journal of Oncology
Shu Chun Chang, Jeak Ling Ding
Cells and soluble mediators of the innate and adaptive immune systems are fundamental components of the tumor microenvironment. Nuclear factors, e.g. transcription factors (TFs) and oncoproteins/cancer suppressors, play important roles in controlling cytokine functions leading to the development, maintenance and metastasis of cancers. Studies focusing on the regulators of the pro-tumorigenic microenvironment are particularly pertinent to early diagnosis and potential development of targeted cancer therapeutics...
August 21, 2018: Biochimica et biophysica acta. Reviews on cancer
Amirhossein Bahreyni, Melika Rezaei, Afsane Bahrami, Majid Khazaei, Hamid Fiuji, Mikhail Ryzhikov, Gordon A Ferns, Amir Avan, Seyed Mahdi Hassanian
Aberrant microRNA (miR) expression is implicated in multiple human malignancies. miR-21, acting as a proto-oncogene, is involved in a variety of cellular processes and tumorigenesis and is frequently overexpressed in some cancer types. Several tumor suppressors, metastatic, and apoptotic genes have been identified as miR-21 targets, including Ras homolog gene family member B, PTEN, Sprouty2, programmed cell death 4, Integrin-β4, and E-cadherin thereby regulating tumor growth, invasion, and metastasis. There is a growing evidence that miR-21 expression is associated with clinical outcomes in patients with colorectal cancer (CRC)...
October 14, 2018: Journal of Cellular Physiology
Liang Huang, Hongcheng Lin, Liang Kang, Pinzhu Huang, Jun Huang, Jinlin Cai, Zhenyu Xian, Peixuan Zhu, Meijin Huang, Liping Wang, Cory J Xian, Jianping Wang, Jianghui Dong
Long noncoding RNAs (lncRNAs) play a critical role in the initiation and progression of colorectal cancer (CRC), but little is known about the function of lncRNAs in the colorectal liver metastasis (CLM). This study was designed to identify specific lncRNAs correlating to liver metastasis of CRC, and to further assess their clinical value. Seventeen patients with primary CRC lesions, adjacent normal mucosa, and synchronous liver metastases lesions were divided into discovery set (six patients) and test set (11 patients)...
October 14, 2018: Journal of Cellular Physiology
Elena Bolzacchini, Alessandro Tuzi, Diego De Palma, Graziella Pinotti
No abstract text is available yet for this article.
September 27, 2018: Digestive and Liver Disease
Zeynali M Shima, Mohammadian Mahshid, Kheradmand Fatemeh, Fathi-Azarbayjani Anahita, Rasmi Yousef, Esna-Ashari Omid, Malekinejad Hassan
Anti-proliferative, anti-metastatic and anti-angiogenic effects of 17‑allylamino‑17‑demethoxy geldanamycin (17-AAG) were studied alone and in combination with Capecitabine (Cap) and/or Irinotecan (IR) on HT-29 human colorectal carcinoma cells. Expression of MMP-9 (matrix metalloproteinase‑9) and VEGF (vascular endothelial growth factor) mRNA was analyzed by real-time PCR method. The study was further followed by wound scratch assay for migration assessment. Nitric oxide content, MDA generation and total anti-oxidant capacity were also assessed...
October 10, 2018: Gene
Ailin Qu, Yongmei Yang, Xin Zhang, Wenfei Wang, Yingjie Liu, Guixi Zheng, Lutao Du, Chuanxin Wang
BACKGROUND: Preoperative prediction of lymph node (LN) status is of crucial importance for appropriate treatment planning in patients with colorectal cancer (CRC). In this study, we sought to develop and validate a non-invasive nomogram model to preoperatively predict LN metastasis in CRC. METHODS: Development of the nomogram entailed three subsequent stages with specific patient sets. In the discovery set (n = 20), LN-status-related miRNAs were screened from high-throughput sequencing data of human CRC serum samples...
October 9, 2018: EBioMedicine
Yang Luo, Jian-Jun Chen, Qiang Lv, Jun Qin, Yi-Zhou Huang, Min-Hao Yu, Ming Zhong
In recent years, accumulating evidence has indicated that long non-coding RNAs (lncRNAs) are powerful factors influencing the progression of multiple malignancies. Although a relationship between the lncRNA NEAT1 (nuclear enriched abundant transcript 1) and colorectal cancer has previously been reported, the functional mechanism underlying the involvement of NEAT1 in colorectal cancer remains unknown. In this study, we report that NEAT1 expression is up-regulated in colorectal cancer tissues, which correlates with advanced clinical features, poor overall survival and disease free survival...
October 9, 2018: Cancer Letters
Keiji Sano, Masakazu Yamamoto, Tetsushige Mimura, Itaru Endo, Shoji Nakamori, Masaru Konishi, Masaru Miyazaki, Toshifumi Wakai, Masato Nagino, Keiichi Kubota, Michiaki Unno, Naohiro Sata, Junji Yamamoto, Hiroki Yamaue, Tadahiro Takada
BACKGROUND: Whether non-colorectal non-neuroendocrine liver metastasis (NCNNLM) should be treated surgically remains unclear. METHODS: Data regarding 1639 hepatectomies performed between 2001 and 2010 for 1539 patients with NCNNLM were collected from 124 institutions. Patient characteristics, types of primary tumor, characteristics of liver metastases, and post-hepatectomy outcomes were analyzed. RESULTS: The 5 most frequent primary tumors were gastric carcinoma (540 patients [35%]), gastrointestinal stromal tumor (204 patients [13%]), biliary carcinoma (150 patients [10%]), ovarian cancer (107 patients [7%]), and pancreatic carcinoma (77 patients [5%])...
October 12, 2018: Journal of Hepato-biliary-pancreatic Sciences
Dehua Zhu, Jianping Zhou, Jinbo Zhao, Guiyang Jiang, Xiupeng Zhang, Yong Zhang, Ming Dong
ZC3H13 is a canonical CCCH zinc finger protein, which harbors a somatic frame-shift mutation in colorectal cancer (CRC). However, its expression and biological function were still uncertain. In the current study, we found that ZC3H13 was served as a tumor suppressor in CRC cells, which decreased the expression of Snail, Cyclin D1, and Cyclin E1, and increased the expression of Occludin and Zo-1 through inactivating Ras-ERK signaling pathway. Furthermore, reduction of ZC3H13 associated with advanced TNM stage (p = 0...
October 12, 2018: Journal of Cellular Physiology
Eon Chul Han, Yoon-Hye Kwon, Kyu Joo Park, Seung-Yong Jeong, Sung-Bum Kang, Jae Hwan Oh, Seung Chul Heo
Purpose: Although lymph node (LN) metastasis is an important prognostic marker of colorectal cancer (CRC), the effect of LN metastasis on the survival of stage IV CRC is debated yet. Methods: LN status and survivals as well as clinicopathological features of synchronous stage IV CRC patients, operated for 8 years, were analyzed. Patients with hematogenous metastases were included only but those with peritoneal seeding or preoperative adjuvant therapy were not included...
October 2018: Annals of Surgical Treatment and Research
Tsung-Hsing Chen, Wey-Ran Lin, Chieh Lee, Cheng-Tang Chiu, Jun-Te Hsu, Ta-Sen Yeh, Kwang-Huei Lin, Puo-Hsien Le, Chau-Ting Yeh
Background: Gastric signet ring cell carcinoma (SRCC) is a histologic variant characterized by abundant intracytoplasmic mucin. Although it has been recognized that gastric adenocarcinoma harboring this feature has poorer prognosis, prognostic stratification within gastric SRCCs themselves has not been clearly defined. N-acetylgalactosaminyltransferase14 (GALNT14) genotype has been associated to poorer treatment outcome in mucinous type colorectal cancer. Here we incorporated clinicopathological factors and GALNT14 genotype to stratify prognosis of advanced gastric SRCC...
2018: Journal of Cancer
Tyler P Robin, David Raben, Tracey E Schefter
Metastases to the liver are common, and stereotactic body radiation therapy (SBRT) is a recognized tool for ablation of liver metastases. Colorectal cancers commonly metastasize to the liver, and long-term survival is possible after metastasectomy. However, many patients are not candidates for surgical resection, which opened the door to early studies investigating noninvasive techniques such as liver SBRT. Multiple prospective trials have demonstrated excellent local control with this approach coupled with an excellent safety record...
October 2018: Seminars in Radiation Oncology
Yuzhu Hu, Cong Wu, Changhui Zhu, Qingyu Fu, Jiajun Guo, Lihong Deng, Yihong He, Daoke Yang, Yongzhong Cheng, Xiang Gao
Colorectal cancer (CRC) exhibited high incidence rate worldwide and the advanced CRC had a poor prognosis. Thereupon, seeking efficient treatment for CRC is critical. Apatinib is a novel vascular epithelial growth factor receptor (VEGFR) inhibitor with inspiring therapeutic effect in some malignant cancers. In our study, doxorubicin was mixed in fibrin gel and apatinib was encapsulated with self-synthesized liposome. The results showed liposomal apatinib (Lipo-Apatinib) could enhance the intracellular uptake of doxorubicin in vitro...
October 8, 2018: International Journal of Pharmaceutics
N Wei, B Zhang, Y Wang, X H He, L C Xu, G D Li, Y H Wang, G Z Wang, H Z Huang, W T Li
PURPOSE: To evaluate and compare the efficiency and safety of raltitrexed- or floxuridine (FUDR)-based transarterial chemoembolization (TACE) in patients with unresectable colorectal cancer liver metastasis (CRCLM). METHODS: We conducted a retrospective analysis of 81 patients with unresectable CRCLM who failed systemic chemotherapy and were treated with TACE in our department from Oct 2014 to Oct 2017. Of these, 61 patients received TACE using raltitrexed, oxaliplatin, and pirarubicin (raltitrexed group), and 20 received TACE using FUDR, oxaliplatin, and pirarubicin (FUDR group)...
October 10, 2018: Clinical & Translational Oncology
Xiangxiang Liu, Xiaoxiang Chen, Kaixuan Zeng, Mu Xu, Bangshun He, Yuqin Pan, Huiling Sun, Bei Pan, Xueni Xu, Tao Xu, Xiuxiu Hu, Shukui Wang
As one of the most common cancers worldwide, colorectal cancer (CRC) causes a large number of mortality annually. Aberrant expression of microRNAs (miRNAs) is significantly associated with the initiation and development of CRC. Further investigations regarding the regulatory mechanism of miRNAs is warranted. In this study, we discovered that miR-486-5p was remarkably downregulated in CRC, which partially results from higher DNA methylation in the promoter region detected by using methylation-specific PCR, bisulfite sequencing PCR, and DNA demethylation treatment...
October 10, 2018: Cell Death & Disease
Ting Yu, Cong Wu, Changhui Zhu, Yihong He, Daoke Yang, Yongzhong Cheng, Xiang Gao
Colorectal cancer is one of the most common and malignant cancer in the world wide. Recently, combination of target therapy and chemotherapy has generated new promise for colorectal cancer. Apatinib mesylate is a novel and highly selective VEGFR-2 inhibitor, presented with an outstanding activity of anti-angiogensis, which has the potential for treating various tumors. As a traditional chemotherapeutic drug, docetaxel (Taxotere) is a widely used semisynthetic taxoid in solid tumors. In this study, Liposome and Methoxy poly(ethylene glycol)-poly( ε -caprolactone) (MPEG-PCL) were constructed as drug delivery system for the delivery of apatinib (Lipo-Apa) and docetaxel (DOC/M), respectively...
December 1, 2018: Journal of Biomedical Nanotechnology
Marcel André Schneider, Janina Eden, Basile Pache, Felix Laminger, Victor Lopez-Lopez, Thomas Steffen, Martin Hübner, Friedrich Kober, Sebastian Roka, Pedro Cascales Campos, Lilian Roth, Anurag Gupta, Alexander Siebenhüner, Vahan Kepenekian, Guillaume Passot, Philippe Gertsch, Olivier Glehen, Kuno Lehmann
BACKGROUND: Adequate selection of patients with peritoneal metastasis (PM) for cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) remains critical for successful long-term outcomes. Factors reflecting tumor biology are currently poorly represented in the selection process. The prognostic relevance of RAS/RAF mutations in patients with PM remains unclear. METHODS: Survival data of patients with colorectal PM operated in 6 European tertiary centers were retrospectively collected and predictive factors for survival identified by Cox regression analyses...
November 2018: Annals of Surgery
Guojun Tong, Wei Xu, Guiyang Zhang, Jian Liu, Zhaozheng Zheng, Yan Chen, Pingping Niu, Xuting Xu
PURPOSE: Tissue carcinoembryonic antigen (t-CEA) and serum carcinoembryonic antigen (s-CEA) expression profiles are the most useful tumor markers for the diagnosis and evaluation of colorectal cancer (CRC) worldwide; however, their roles in CRC progression remain controversial. This study aimed to compare the prognostic values of both s-CEA and t-CEA in CRC. METHODS: A total of 517 patients from January 2006 to December 2010 with stages I-III CRC were retrospectively examined, with 5-year postoperative follow-up and death as end-points...
October 9, 2018: Cancer Medicine
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