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Colorectal Cancer Metastasis

Markus S Zimmermann, Ulrich Wellner, Tilman Laubert, David Ellebrecht, Hans-Peter Bruch, Tobias Keck, Erik Schlöricke, Claudia Benecke
BACKGROUND: The occurrence of anastomotic leakage is still a life-threatening complication for patients after colorectal surgery. In literature not only an impact on the short-term outcome but also on long-term survival and local recurrence of colorectal cancer patients is discussed. OBJECTIVE: This study aimed to investigate the impact of anastomotic leakage on long-term survival and local recurrence. DESIGN: A total of 1122 patients with resections for colorectal cancer were analyzed...
November 28, 2018: Diseases of the Colon and Rectum
Claudemiro Quireze Junior, Andressa Machado Santana Brasil, Lúcio Kenny Morais, Edmond Raymond Le Campion, Eliseu José Fleury Taveira, Matheus Castrillon Rassi
BACKGROUND: Liver metastases from colorectal cancer are an important public health problem due to the increasing incidence of colorectal cancer worldwide. Synchronous colorectal liver metastasis has been associated with worse survival, but this prognosis is controversial. OBJECTIVE: The objective of this study was to evaluate the recurrence-free survival and overall survival between groups of patients with metachronous and synchronous colorectal hepatic metastasis...
July 2018: Arquivos de Gastroenterologia
Kexin Zhao, Si Jin, Bo Wei, Shiqiong Cao, Zhifan Xiong
Introduction: Colorectal cancer (CRC) remains a major public health concern worldwide. However, the detailed molecular mechanisms of CRC remain poorly understood. Methods: In the current study, we evaluated associations of four genetic variants located in the promoter and gene region of long noncoding RNAs metastasis-associated lung adenocarcinoma transcript 1 (lncRNA MALAT1) with CRC susceptibility among a Chinese population with 966 CRC cases and 988 healthy controls, using a two-stage, case-control study design (400 CRC cases and 400 controls in stage 1, and 566 CRC cases and 588 controls in stage 2)...
2018: Cancer Management and Research
Xiong-Bo Guo, Bin Huang, Ying-Hua Pan, Shu-Guang Su, Yan Li
Background: Establishment of cohesion 1 homolog 2 (ESCO2) plays important roles in the regulation of cohesion and genomic stability and has been implicated in human cancers. Yet, its clinical significance and biological function in colorectal cancer (CRC) are unknown. Methods: The expression of ESCO2 was examined by quantitative real-time PCR, Western blot, and immunohistochemistry. The role of ESCO2 in the tumor metastasis of CRC and the related mechanisms were investigated using in vitro and in vivo models...
2018: Cancer Management and Research
Shekhar Gogna, Priya Goyal
The liver is the most common site for metastasis from colorectal cancers (CRCs). There are so many new armamentarium, which have increased the life expectancy and progression-free survival. There are various available guidelines, such as NCCN, ESMO, and ASCO, which provide an insight into the latest modalities and new protocols. We have tried to elucidate into paradigm shift of the management.
December 2018: Indian Journal of Surgical Oncology
Garima Suman, Akshay D Baheti, Suman Kumar Ankathi, Nitin Shetty, Suyash Kulkarni, Vikas Ostwal, Avanish P Saklani
Close surveillance of colorectal cancer (CRC) patients is helpful as early detection of resectable metastasis has a survival benefit. Ultrasonography (USG) is a frequently used modality to detect liver recurrence, although international guidelines do not include it. To evaluate the potential added role of USG in early detection of CRC recurrence. We performed a retrospective analysis of 230 patients of colorectal cancer treated at our institute in 2013-2014 who underwent abdominal USG for surveillance. 77/230 (33%) developed recurrence, with liver being the second most common site (22/230)...
December 2018: Indian Journal of Surgical Oncology
Pridvi Kandagatla, Lilias H Maguire, Karin M Hardiman
Colorectal cancer (CRC) lymph node metastases are common but their genetics and the mechanism whereby these metastases occur are not well understood. Here we present recent data regarding genetic heterogeneity in primary CRCs and their metastasis. In addition, we explain the different potential models describing the mechanisms of metastasis and the data supporting them. Multiple studies have also revealed a variety of prognostic molecular markers that are associated with lymph node metastasis in CRC. A better understanding of genetic heterogeneity and the mechanisms of metastasis is critical to predicting clinical response and resistance to targeted therapy...
December 11, 2018: European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes
Marc Van den Eynde, Bernhard Mlecnik, Gabriela Bindea, Tessa Fredriksen, Sarah E Church, Lucie Lafontaine, Nacilla Haicheur, Florence Marliot, Mihaela Angelova, Angela Vasaturo, Daniela Bruni, Anne Jouret-Mourin, Pamela Baldin, Nicolas Huyghe, Karin Haustermans, Annelies Debucquoy, Eric Van Cutsem, Jean-Francois Gigot, Catherine Hubert, Alex Kartheuser, Christophe Remue, Daniel Léonard, Viia Valge-Archer, Franck Pagès, Jean-Pascal Machiels, Jérôme Galon
Treatment of metastatic colorectal cancer is based upon the assumption that metastases are homogeneous within a patient. We quantified immune cell types of 603 whole-slide metastases and primary colorectal tumors from 222 patients. Primary lesions, and synchronous and metachronous metastases, had a heterogeneous immune infiltrate and mutational diversity. Small metastases had frequently a low Immunoscore and T and B cell score, while a high Immunoscore was associated with a lower number of metastases. Anti-epidermal growth factor receptor treatment modified immune gene expression and significantly increased T cell densities in the metastasis core...
December 10, 2018: Cancer Cell
Lingchuan Guo, Jianhong Fu, Shimei Sun, Minsheng Zhu, Lifeng Zhang, Hui Niu, Zhi Chen, Yongsheng Zhang, Lingling Guo, Shouli Wang
MicroRNAs, which regulate messenger RNAs, operate through a variety of signaling pathways to participate in the development of colorectal cancer (CRC). In this study, we found that miR-143-3p expression was significantly lower in both CRC and liver metastatic CRC tissues from liver compared with normal colonic tissues. Functional assays showed that miR-143-3p inhibited CRC cell invasion and migration in vitro. Using a bioinformatics approach, we identified miR-143-3p target mRNAs. Among the candidate targets, only the expression of integrin alpha 6 (ITGA6) and ArfGAP with the SH3 domain and ankyrin repeat and PH domain 3 (ASAP3) were significantly reduced by miR-143-3p mimics as examined by western blot, and the metastasis potential of CRC cells was attenuated by endogenous ITGA6 and ASAP3 knockdown, determined by migration and invasion assays...
December 11, 2018: Cancer Science
Mostafa Sarvizadeh, Faezeh Ghasemi, Fatemeh Tavakoli, Sara Sadat Khatami, Ebrahim Razi, Hossein Sharifi, Nousin Moussavi Biouki, Mohsen Taghizadeh
Colorectal cancer (CRC) is known as the third most common and fourth leading cancer associated death worldwide. The occurrence of metastasis has remained as a critical challenge in CRC, so that distant metastasis (mostly to the liver) has been manifested in about 20%-25% of patients. Several screening approaches have introduced for detecting CRC in different stages particularly in early stages. The standard treatments for CRC are surgery, chemotherapy and radiotherapy, in alone or combination. Immunotherapy is a set of novel approaches with the aim of remodeling the immune system battle with metastatic cancer cells, such as immunomodulatory monoclonal antibodies (immune checkpoint inhibitors), adoptive cell transfer (ACT) and cancer vaccine...
December 9, 2018: Journal of Cellular Biochemistry
Z-Y Liu, L Yang, H-Y Chang
OBJECTIVE: MicroRNAs (miRNAs) as a new class of biomarkers have been explored in recent studies. We investigate whether miR-1256 could be considered as powerful biomarkers for predicting the prognosis of colorectal cancer (CRC). PATIENTS AND METHODS: The expression of miR-1256 in CRC was compared with matched normal tissue and using qRT-PCR. The correlation of miR-1256 expression with clinicopathological factors was statistically analyzed. Survival rate was determined with Kaplan-Meier and statistically analyzed with the log-rank method between groups...
November 2018: European Review for Medical and Pharmacological Sciences
P Viannay, A Hamy, R Jaouen, F X Caroli-Bosc, C Luel, S Vasseur, M Levaillant, J F Hamel, Aurélien Venara
PURPOSE: The advantages of enhanced recovery programs (ERP) after colorectal surgery for morbidity and length of stay are well known. On a longer term, evidence is much more limited. The aim of this study is to determine the impact of ERP on survival after 3 years of follow-up, following colorectal cancer surgery. METHODS: All the patients undergoing resection for colorectal cancer between the years 2010 and 2014 were included. Patients were classified according to their compliance with the ERP (< 70 or ≥ 70%)...
December 7, 2018: International Journal of Colorectal Disease
Zhuoqi Xuan, Jianming Huang, Lin Gao, Yong Wang, Jiandong Wang, Yueming Sun
Although EphB3 expression is down-regulated in colorectal cancer (CRC) cells compared with normal intestinal epithelial cells, the relationship between EphB3 expression and clinicopathological parameters in CRC is unclear. We examined EphB3 expression in 128 CRC tissue specimens and in 19 adenoma specimens using immunohistochemistry. The relationships between EphB3 expression and clinicopathological parameters, KRAS mutations, BRAF V600E mutation, MSI and survival were evaluated using Spearman's rank correlation and Kaplan-Meier survival analyses, respectively...
December 7, 2018: Pathology Oncology Research: POR
Huai-Qiang Ju, Yun-Xin Lu, Dong-Liang Chen, Zhi-Xiang Zuo, Ze-Xian Liu, Qi-Nian Wu, Hai-Yu Mo, Zi-Xian Wang, De-Shen Wang, Heng-Ying Pu, Zhao-Lei Zeng, Bo Li, Dan Xie, Peng Huang, Mien-Chie Hung, Paul J Chiao, Rui-Hua Xu
Background: Overcoming oxidative stress is a critical step for tumor progression; however, the underlying mechanisms in colorectal cancer (CRC) remain unclear. Methods: We investigated nicotinamide adenine dinucleotide (phosphate) (NAD(P))-dependent enzyme methylene tetrahydrofolate dehydrogenase 2 (MTHFD2) expression, clinical relevance, redox modification, and molecular mechanisms using the CRC cells and tissues (n = 462 paired samples). The antitumor effects of MTHFD2 inhibitor LY345899 on CRC tumorigenesis and metastasis were evaluated in vitro and in vivo...
December 8, 2018: Journal of the National Cancer Institute
Lin Yang, Wenzhuo He, Qiankun Xie, Shousheng Liu, Pengfei Kong, Chang Jiang, Bei Zhang, Liangping Xia
Background: Population-based incidence evaluations and prognosis assessments of brain metastasis (BM) at diagnosis of colorectal cancer (CRC) are lacking. Our study sought to determine the incidence of BM in CRC patients, median survival of patients with BM, and the risk factors of BM in CRC. Patients and methods: Patients diagnosed with CRC were identified using the Surveillance, Epidemiology, and End Results database. Multivariable logistic and Cox regression analyses were performed to identify predictors of the presence of BM at CRC diagnosis and the factors associated with poor survival...
2018: Cancer Management and Research
Zhenqiang Sun, Chunlin Ou, Jinbo Liu, Chen Chen, Quanbo Zhou, Shuaixi Yang, Guiyuan Li, Guixian Wang, Junmin Song, Zhen Li, Zhiyong Zhang, Weitang Yuan, Xiayu Li
Yes-associated protein 1 (YAP1) exerts significant effects in various malignancies. However, the oncogenic role of YAP1 remains controversial, and the mechanism by which YAP1 regulates non-coding RNAs is still largely unknown. The present study aimed to assess the effect of YAP1 on the malignant behaviors of colorectal carcinoma (CRC) and explore the underlying regulatory mechanism of the YAP1-MALAT1-miR-126-5p axis. YAP1 was highly expressed in CRC tissues as assessed by GSE20916 and its expression was negatively correlated with overall survival in 83 CRC cases...
December 10, 2018: Oncogene
Kun Wang, Tengyan Li, Chang Xu, Yuhan Ding, Wenjing Li, Lei Ding
The dysregulation of the tight junctions (TJs) protein claudin-7 is closely related to the development and metastasis of colorectal cancer (CRC). The aim of this study was to investigate the expression of claudin-7 and characterize the relationship between claudin-7 expression and epithelial-mesenchymal transition (EMT) in CRC. In this study, the expression of claudin-7, E-cadherin, vimentin and snail-1 was detected by immunohistochemistry (IHC) in a set of 80 CRC specimens comprising 20 specimens each of well-differentiated, moderately differentiated, poorly differentiated and liver metastases tissues...
December 6, 2018: Biochemical and Biophysical Research Communications
Li Yan, Wei-Qiang You, Neng-Quan Sheng, Jian-Feng Gong, Lan-Dian Hu, Ge-Wen Tan, Hong-Qi Chen, Zhi-Gang Wang
Increasing evidence has indicated the prognostic value of miR-433 across a series of malignancy types. However, the underlying mechanisms involved in cancer progression haven't been sufficiently elucidated. In the present work, we found that miR-433 was downregulated in CRC tissues and cell lines. Ectopic expression of miR-433 obviously suppressed the proliferation, invasion and metastasis activity of CRC cells in vitro and in vivo. CREB1, CCAR1 and JNK1 were highly expressed and negatively correlated with miR-433 expression in CRC...
December 6, 2018: Aging
Yang Feng, Yaqi Li, Weixing Dai, Shaobo Mo, Qingguo Li, Sanjun Cai
BACKGROUND/AIMS: Alpha-fetoprotein-producing colorectal cancer (AFPP-CRC) is quite rarely seen. This study aimed to elucidate the clinicopathologic characteristics and prognostic factors of AFPP-CRC. METHODS: Among 5,051 colorectal cancer patients receiving surgery in the Fudan University Shanghai Cancer Center from 2006 to 2016, we identified 78 patients with elevated serum level of AFP (> 10 µg/L) preoperatively. A propensity score matching (PSM) analysis was performed which matched 75 AFPP-CRC patients to the same number of AFP-negative colorectal cancer (AFPN-CRC) patients...
2018: Cellular Physiology and Biochemistry
Ruohua Chen, Yining Wang, Xiang Zhou, Gang Huang, Jianjun Liu
Purpose: We evaluated the prognostic value of preoperative 18 F-FDG uptake by suspected lymph nodes (LNs) using 18 F-FDG PET/CT in colorectal cancer patients. Methods: Patients with CRC underwent 18 F-FDG PET/CT before radical surgery. We used Cox proportional hazards regression to examine the relationship between recurrence and the 18 F-FDG maximum standardized uptake value (SUVmax) in the suspected LNs (SUVLN ) on 18 F-FDG PET/CT. Results: Clinical data, treatment modalities, and results from 90 CR C patients were reviewed...
2018: Contrast Media & Molecular Imaging
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