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Missing Metastasis

Matthias Christgen, Stephan Bartels, Angelina Luft, Sascha Persing, Daniel Henkel, Ulrich Lehmann, Hans Kreipe
In addition to amplification, point mutations of the human epidermal growth factor receptor 2 (HER2) gene (ERBB2) have been shown to activate the corresponding signaling pathway in breast cancer. The prevalence of ERBB2/HER2 mutation in bone metastasis of breast cancer and the associated phenotype are not known. In this study, bone metastases from breast cancer patients (n = 231) were analyzed for ERBB2/HER2 mutation. In 7 patients (3%; median age 70 years, range 50-83 years), gain-of-function mutations of ERBB2/HER2 were detected...
August 9, 2018: Virchows Archiv: An International Journal of Pathology
Somali Pattanayak, Samar Chatterjee, R Ravikumar, V S Nijhawan, Vivek Sharma, Jyotindu Debnath
Background: The differentiation between the causes of cervical lymphadenopathy is of paramount importance as these have different modalities of treatment with varying prognosis. The aim of this study was to evaluate the efficacy of B Mode and colour Doppler ultrasound (CDUS) to differentiate between benign and metastatic lymph nodes. Methods: 100 patients of clinically palpable lymph nodes were evaluated with B Mode and CDUS. B Mode assessment included short-long (S:L) axis ratio, hilum, nodal border, echogenicity, intranodal necrosis and ancillary features...
July 2018: Medical Journal, Armed Forces India
Siyu Wu, Yujie Wang, Na Zhang, Jianwei Li, Xiaoli Xu, Juping Shen, Guangyu Liu
BACKGROUND: For breast cancer patients, a false-negative rate lower than 10% can be achieved if targeted axillary dissection (TAD) is performed, which includes the excision of both biopsy-proven positive lymph nodes (BxLNs) and sentinel lymph nodes (SLNs). However, little evidence exists on the accuracy of intraoperative touch imprint cytology (ITPC) applied in TAD after neoadjuvant chemotherapy (NAC) for breast cancer patients with initial axillary metastasis. This study aimed to investigate the accuracy of ITPC in TAD after NAC...
August 6, 2018: Annals of Surgical Oncology
Debdeep Banerjee, Saikiran Raghavapuram, Nayana E George, Soheila Korourian, Faysal A Fedda, Abhilash Perisetti, Benjamin Tharian
Cholangiocarcinoma offers poor prognosis. Infrequent sites of metastasis are poorly described and often diagnostically delayed or missed. Bile duct brush cytologies provide poor diagnostic sensitivity/specificity. We present an unusual case of cholangiocarcinoma in a 34-year-old woman with rare distant metastasis to the psoas muscle and urinary bladder. It is the first case of metastatic cholangiocarcinoma presenting as linitis plastica, and our patient is the youngest to be described with metastatic cholangiocarcinoma to the psoas muscle leading to diagnosis...
2018: ACG Case Reports Journal
Kenta Tominaga, Yasuhiro Kurumiya, Ei Sekoguchi, Satoshi Kobayashi, Kiyotaka Kawai, Muneyasu Kiriyama
A 62-year-old man was diagnosed with liver metastasis of sigmoid colon cancer, which resulted in bowel obstruction. SOX plus bevacizumab therapy was administered to perform hepatectomy, after the artificial anus construction; however, substantial liver dysfunction occurred. Therefore, we only performed primary tumor resection and waited for improvement in liver function. After 2 months, liver function improved and liver metastasis increased. However, another metastasis was not recognized, so hepatectomy was carried out, and R0 resection was performed...
June 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Omar Abdel-Rahman
OBJECTIVE: The aim of the current study is to evaluate the performance characteristics of the National Comprehensive Cancer Network (NCCN) staging recommendations for breast cancer with regard to the detection of lung, bone, and liver metastases. METHODS: Surveillance, epidemiology, and end points (SEER) database (2010-2015) was accessed, and patients with breast cancer and complete information about T stage and clinical N stage, ER status, Her2 status, and metastatic sites were extracted...
July 18, 2018: Breast Cancer Research and Treatment
Anick Nater, Lindsay A Tetreault, Branko Kopjar, Paul M Arnold, Mark B Dekutoski, Joel A Finkelstein, Charles G Fisher, John C France, Ziya L Gokaslan, Laurence D Rhines, Peter S Rose, Arjun Sahgal, James M Schuster, Alexander R Vaccaro, Michael G Fehlings
BACKGROUND: This study was designed to identify preoperative predictors of survival in surgically treated patients with metastatic epidural spinal cord compression (MESCC), to examine how these predictors are related to 8 prognostic models, and to perform the first full external validation of these models in accordance with the Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD) statement. METHODS: One hundred forty-two surgically treated patients with MESCC were enrolled in a prospective, multicenter North American cohort study and were followed for 12 months or until death...
July 5, 2018: Cancer
Stephan Marquardt, Manish Solanki, Alf Spitschak, Julio Vera, Brigitte M Pützer
Metastasis is one of the most challenging issues in cancer patient management, and effective therapies to specifically target disease progression are missing, emphasizing the urgent need for developing novel anti-metastatic therapeutics. Cancer stem cells (CSCs) gained fast attention as a minor population of highly malignant cells within liquid and solid tumors that are responsible for tumor onset, self-renewal, resistance to radio- and chemotherapies, and evasion of immune surveillance accelerating recurrence and metastasis...
June 30, 2018: Seminars in Cancer Biology
Michael L Drummond, Mischa Li, Eric Tarapore, Tuyen T L Nguyen, Baina J Barouni, Shaun Cruz, Kevin C Tan, Anthony E Oro, Scott X Atwood
Primary cilia are polarized organelles that allow detection of extracellular signals such as Hedgehog (Hh). How the cytoskeleton supporting the cilium generates and maintains a structure that finely tunes cellular response remains unclear. Here, we find that regulation of actin polymerization controls primary cilia and Hh signaling. Disrupting actin polymerization, or knockdown of N-WASp/Arp3, increases ciliation frequency, axoneme length, and Hh signaling. Cdc42, a potent actin regulator, recruits both atypical protein pinase C iota/lambda (aPKC) and Missing-in-Metastasis (MIM) to the basal body to maintain actin polymerization and restrict axoneme length...
June 26, 2018: Journal of Cell Biology
Nikolas G Balanis, Thomas G Graeber
Lethal cancers have genomes that can reflect a jigsaw puzzle put together in a hurricane. The missing, misjoined, and extra pieces contribute to the driving forces behind the cancer phenotypes. But is this the only reason genomic instability is so prevalent in aggressive cancers? New findings support that the hurricane winds themselves, not just their aftermath, contribute to the cancer phenotype of metastasis.
July 2018: Trends in Cancer
Dong Young Jeong, Min Yeong Kim, Kyung Soo Lee, Joon Young Choi, Soo Jeong Kim, Myung Jin Chung, Yang Won Min, Hong Kwan Kim, Jae Ill Zo, Young Mog Shim, Jong-Mu Sun
This study aimed to evaluate the frequency of nodal metastases and to disclose the diagnostic performance of endoscopic ultrasonography (EUS) and PET/CT in T and N staging in surgically resected early-stage esophageal squamous cell carcinomas (eSCCs). Institutional review board approved this retrospective study with waiver of informed consent for reviewing medical record. We included 435 patients with an early T-stage (Tis or T1a [≤T1a], T1b and T2) eSCC. The rates of metastatic lymphadenopathy were calculated...
June 22, 2018: Cancer Medicine
Litao Yan, Junwei Zong, Jin Chu, Wendong Wang, Mingshu Li, Xianfeng Wang, Mingzhi Song, Shouyu Wang
The calcaneus is a rare location for the occurrence and development of primary tumour types. Clinicians are unfamiliar with calcaneal tumour types, which may result in a delay in diagnosis or a missed diagnosis, resulting in unnecessary morbidity and amputation. Heel pain and localized swelling of the ankle are the most common symptoms. X-ray is the first choice for a tentative diagnosis of a calcaneal tumour. The final diagnosis depends on a histological examination. The treatment of calcaneal tumour types varies depending on the Enneking system...
June 2018: Oncology Letters
Allen M Chen, Taeko Yoshizaki, Pin-Chieh Wang, Darlene Veruttipong, Phillip J Beron, Robert Chin, Argin G Mikaeilian, Minsong Cao
Purpose: The practice of deliberately sparing the ipsilateral parotid gland with intensity modulated radiation therapy (IMRT) in patients with node-positive head and neck cancer is controversial. We sought to compare the clinical outcomes among consecutive cohorts of patients with head and neck cancer who were treated with differing strategies to spare the parotid gland that is ipsilateral to the involved neck using IMRT. Methods and materials: A total of 305 patients were treated with IMRT for node-positive squamous cell carcinoma of the head and neck...
April 2018: Advances in Radiation Oncology
Luca Vigano, Luca Di Tommaso, Antonio Mimmo, Mauro Sollai, Matteo Cimino, Matteo Donadon, Massimo Roncalli, Guido Torzilli
BACKGROUND: Patients with numerous colorectal liver metastases (CLM) have high risk of early recurrence after liver resection (LR). The presence of intrahepatic occult microscopic metastases missed by imaging has been hypothesized, but it has never been assessed by pathology analyses. METHODS: All patients with > 10 CLM who underwent LR between September 2015 and September 2016 were considered. A large sample of liver without evidence of disease ("healthy liver") was taken from the resected specimen and sent to the pathologist...
June 7, 2018: Digestive Surgery
Peng Lin, Nong Lin, Wangsiyuan Teng, Sheng-Dong Wang, Wei-Bo Pan, Xin Huang, Xiao-Bo Yan, Meng Liu, Heng-Yuan Li, Bing-Hao Li, Ling-Ling Sun, Zhan Wang, Xing-Zhi Zhou, Zhao-Ming Ye
OBJECTIVE: To review the clinical details and further treatments for recurrent spinal giant cell tumors (SGCT), and to analyze the risk factors of recurrence and shed new light on the treatment options and prognosis of recurrent SGCT. METHODS: A retrospective analysis of recurrent SGCT between April 2003 and January 2014 was performed. A total of 10 patients comprising 3 men and 7 women with a mean age of 28.9 years (range, 21-40 years) were included in the study...
May 2018: Orthopaedic Surgery
Christoph Schwarz, Klaus Kaczirek, Martin Bodingbauer
Whereas liver resection for colorectal metastasis has become standard of care, hepatectomy in patients with non-colorectal metastases remains controversial, mainly due to a heterogeneous tumor biology and missing data from prospective trials. This review aims at giving an overview about the indications and limits of liver surgery in patients with an advanced disease of a non-colorectal malignancy. Even though prospective trials are largely missing, results from retrospective studies indicate a survival benefit for liver resection in selected patients...
2018: European Surgery: ACA: Acta Chirurgica Austriaca
Arnab Ghosh, Sandipto Sarkar, Snigdha Banerjee, Fariba Behbod, Ossama Tawfik, Douglas McGregor, Stephanie Graff, Sushanta K Banerjee
Mouse models of breast cancer with specific molecular subtypes (e.g., ER or HER2 positive) in an immunocompetent or an immunocompromised environment significantly contribute to our understanding of cancer biology, despite some limitations, and they give insight into targeted therapies. However, an ideal triple-negative breast cancer (TNBC) mouse model is lacking. What has been missing in the TNBC mouse model is a sequential progression of the disease in an essential native microenvironment. This notion inspired us to develop a TNBC-model in syngeneic mice using a mammary intraductal (MIND) method...
2018: PloS One
Tessa N van de Lindt, Martin F Fast, Uulke A van der Heide, Jan-Jakob Sonke
PURPOSE: Daily MRI-guidance for liver radiotherapy is becoming possible on an MR-Linac. The purpose of this study was to develop a 4D-MRI strategy using an image-based respiratory signal with an acquisition-reconstruction time <5 min, providing T2-weighting for non-contrast enhanced tumor visibility. MATERIALS AND METHODS: Images were acquired using an axial multi-slice 2D Turbo Spin Echo (TSE) sequence, repeated a variable number of times (dynamics). A self-sorting signal (SsS) was retrieved from the data by computing correlation coefficients between all acquired slices...
June 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Giuseppe Falco, Simone Mele, Maurizio Zizzo, Graziella Di Grezia, Paolo Cecinato, Giulia Besutti, Saverio Coiro, Gianluca Gatta, Rita Vacondio, Guglielmo Ferrari
INTRODUCTION: Metastatic spread in invasive lobular carcinoma (ILC) of breast mainly occurs in bones, gynecological organs, peritoneum, retroperitoneum, and gastrointestinal (GI) tract. Metastases to the GI tract may arise many years after initial diagnosis and can affect the tract from the tongue to the anus, stomach being the most commonly involved site. Clinical presentations are predominantly nonspecific, and rarely asymptomatic. CEA, CA 15-3, and CA 19-9 may be informative for symptomatic patients who have had a previous history of breast cancer...
May 2018: Medicine (Baltimore)
Ana M Franceschi, Robert Matthews, Lev Bangiyev, Nand Relan, Ammar Chaudhry, Dinko Franceschi
OBJECTIVE: FDG PET/MRI examination of the body is routinely performed from the skull base to the mid thigh. Many types of brain abnormalities potentially could be detected on PET/MRI if the head was included. The objective of this study was therefore to identify and characterize brain findings incidentally detected on PET/MRI of the body with the head included. MATERIALS AND METHODS: We retrospectively identified 269 patients with FDG PET/MRI whole-body scans that included the head...
July 2018: AJR. American Journal of Roentgenology
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