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Missing Metastasis

Lu Zhang, Jin Hu, A Ali Zirakzadeh, Jesper Rosvall, Mats Hedlund, Ping Sheng Hu, Robert P A Wallin, Amir Sherif, Ola Winqvist
BACKGROUND: The tumor draining lymph node concept was first described in penile cancer for staging. Immunohistochemistry and histopathology evaluations are routinely used in clinical practice to examine lymph nodes for metastasis. However, these methods are time-consuming with low diagnostic accuracy and micro-metastases might be missed. In this study, we aim to evaluate detection of metastatic cells in draining lymph nodes by flow cytometry. METHODS: To assess the sensitivity of micro-metastasis detection by FACS (Fluorescence-activated cell sorting), HeLa cells were titrated into Peripheral blood mononuclear cells (PBMCs) and expression of pan-cytokeratin AE1/AE3 was analyzed...
October 5, 2018: BMC Urology
Florian Bochen, Benedikt Balensiefer, Sandrina Körner, Jörg Thomas Bittenbring, Frank Neumann, Armand Koch, Klaus Bumm, Anke Marx, Silke Wemmert, Georgios Papaspyrou, David Zuschlag, Jan Philipp Kühn, Basel Al Kadah, Bernhard Schick, Maximilian Linxweiler
Vitamin D deficiency is frequently observed in human cancer patients and a prognostic relevance could be shown for some entities. Additionally, it is known that vitamin D can stimulate the patients' antitumor immunity. However, valid epidemiological data for head and neck squamous cell carcinoma (HNSCC) patients are sparse and functional studies on a possible connection between vitamin D and the patients' immune system are missing. 25-OH vitamin D serum levels were analyzed in 231 HNSCC patients and 232 healthy controls and correlated with clinical data and patient survival...
2018: Oncoimmunology
Michael A Garcia, Mekhail Anwar, Yao Yu, Sai Duriseti, Bryce Merritt, Jean Nakamura, Christopher Hess, Philip V Theodosopoulos, Michael McDermott, Penny K Sneed, Steve E Braunstein
PURPOSE: A previous analysis showed that brain metastases that are treated with frameless stereotactic radiation surgery (SRS) and planned with magnetic resonance imaging (MRI) >14 days before SRS had worse local control (LC). To evaluate if worse LC may be due to unaccounted interval metastasis growth and radiosurgical marginal miss, we quantified growth before SRS on preradiosurgical imaging. METHODS AND MATERIALS: We reviewed data from patients who were treated with fixed-frame SRS for brain metastases at our institution between 2010 and 2013 and had pretreatment diagnostic brain MRI and SRS-planning MRI scans available...
June 7, 2018: Practical Radiation Oncology
S Agostinelli, S Garelli, M Gusinu, M Zeverino, F Cavagnetto, F Pupillo, A Bellini, G Taccini
PURPOSE: This paper analyzes Tomotherapy-based intracranial stereotactic radiosurgery (HTSRS) of brain metastasis targeting two end-points: 1) evaluation of dose homogeneity, conformity and gradient scores for single and multiple lesions and 2) assay of dosimetric criticality of completion of HTSRS procedures. METHODS: 42 treatment plans of 33 patients (53 brain lesions) treated with HTSRS were analyzed. Dose to healthy brain, homogeneity, conformity and gradient indexes were evaluated for each lesion...
August 2018: Physica Medica: PM
Cristian P Moiola, Carlos Lopez-Gil, Silvia Cabrera, Angel Garcia, Tom Van Nyen, Daniela Annibali, Tina Fonnes, August Vidal, Alberto Villanueva, Xavier Matias-Guiu, Camilla Krakstad, Frédéric Amant, Antonio Gil-Moreno, Eva Colas
Endometrial cancer (EC) is the most common malignancy of the genital tract among women in developed countries. Recently, a molecular classification of EC has been performed providing a system that, in conjunction with histological observations, reliably improves EC classification and enhances patient management. Patient-derived xenograft models (PDX) represent nowadays a promising tool for translational research, since they closely resemble patient tumour features and retain molecular and histological features...
August 17, 2018: International Journal of Molecular Sciences
Victoria M L Cohen, Efthymia Pavlidou, Joanna DaCosta, Amit K Arora, Teressa Szyszko, Mandeep S Sagoo, Peter Szlosarek
PURPOSE: The purpose of this study was to report the results of staging primary uveal melanoma with whole-body (18) fluorodeoxyglucose (FDG) positron-emission tomography/computed tomography (PET/CT) and abdominal ultrasound. MATERIALS AND METHODS: From January 2012, patients with uveal melanoma over 4 mm in thickness were staged with FDG PET/CT and abdominal ultrasound. RESULTS: Over 2 years, 108 patients with medium-to-large melanoma underwent dual imaging...
April 2018: Middle East African Journal of Ophthalmology
Thabo Lengana, Ismaheel O Lawal, Tebatso G Boshomane, Gbenga O Popoola, Kgomotso M G Mokoala, Evelyn Moshokoa, Alex Maes, Neo P Mokgoro, Christophe Van de Wiele, Mariza Vorster, Mike M Sathekge
PURPOSE: 68 Ga ligands targeting prostate-specific membrane antigen (PSMA) are rapidly emerging as a significant step forward in the management of prostate cancer. PSMA is a type II transmembrane protein with high expression in prostate carcinoma cells. We prospectively evaluated the use of 68 Ga-PSMA positron emission tomography/computed tomography (PET/CT) in patients with prostate cancer and compared the results to those for technetium-99m (99m Tc)-10-metacyloyloxydecyl dihydrogen phosphate (MDP) bone scintigraphy (BS)...
July 21, 2018: Clinical Genitourinary Cancer
L S Shuyskiy, V V Levchenko, Y A Negulyaev, A V Staruschenko, D V Ilatovskaya
Epithelial Sodium Channels (ENaCs) are expressed in different organs and tissues, particularly in the cortical collecting duct (CCD) in the kidney, where they fine tune sodium reabsorption. Dynamic rearrangements of the cytoskeleton are one of the common mechanisms of ENaC activity regulation. In our previous studies, we showed that the actin-binding proteins cortactin and Arp2/3 complex are involved in the cytoskeleton-dependent regulation of ENaC and that their cooperative work decreases a channel's probability of remaining open; however, the specific mechanism of interaction between actin-binding proteins and ENaC is unclear...
April 2018: Acta Naturae
Matthias Christgen, Stephan Bartels, Angelina Luft, Sascha Persing, Daniel Henkel, Ulrich Lehmann, Hans Kreipe
In addition to amplification, point mutations of the human epidermal growth factor receptor 2 (HER2) gene (ERBB2) have been shown to activate the corresponding signaling pathway in breast cancer. The prevalence of ERBB2/HER2 mutation in bone metastasis of breast cancer and the associated phenotype are not known. In this study, bone metastases from breast cancer patients (n = 231) were analyzed for ERBB2/HER2 mutation. In 7 patients (3%; median age 70 years, range 50-83 years), gain-of-function mutations of ERBB2/HER2 were detected...
August 9, 2018: Virchows Archiv: An International Journal of Pathology
Somali Pattanayak, Samar Chatterjee, R Ravikumar, V S Nijhawan, Vivek Sharma, Jyotindu Debnath
Background: The differentiation between the causes of cervical lymphadenopathy is of paramount importance as these have different modalities of treatment with varying prognosis. The aim of this study was to evaluate the efficacy of B Mode and colour Doppler ultrasound (CDUS) to differentiate between benign and metastatic lymph nodes. Methods: 100 patients of clinically palpable lymph nodes were evaluated with B Mode and CDUS. B Mode assessment included short-long (S:L) axis ratio, hilum, nodal border, echogenicity, intranodal necrosis and ancillary features...
July 2018: Medical Journal, Armed Forces India
Siyu Wu, Yujie Wang, Na Zhang, Jianwei Li, Xiaoli Xu, Juping Shen, Guangyu Liu
BACKGROUND: For breast cancer patients, a false-negative rate lower than 10% can be achieved if targeted axillary dissection (TAD) is performed, which includes the excision of both biopsy-proven positive lymph nodes (BxLNs) and sentinel lymph nodes (SLNs). However, little evidence exists on the accuracy of intraoperative touch imprint cytology (ITPC) applied in TAD after neoadjuvant chemotherapy (NAC) for breast cancer patients with initial axillary metastasis. This study aimed to investigate the accuracy of ITPC in TAD after NAC...
October 2018: Annals of Surgical Oncology
Debdeep Banerjee, Saikiran Raghavapuram, Nayana E George, Soheila Korourian, Faysal A Fedda, Abhilash Perisetti, Benjamin Tharian
Cholangiocarcinoma offers poor prognosis. Infrequent sites of metastasis are poorly described and often diagnostically delayed or missed. Bile duct brush cytologies provide poor diagnostic sensitivity/specificity. We present an unusual case of cholangiocarcinoma in a 34-year-old woman with rare distant metastasis to the psoas muscle and urinary bladder. It is the first case of metastatic cholangiocarcinoma presenting as linitis plastica, and our patient is the youngest to be described with metastatic cholangiocarcinoma to the psoas muscle leading to diagnosis...
2018: ACG Case Reports Journal
Kenta Tominaga, Yasuhiro Kurumiya, Ei Sekoguchi, Satoshi Kobayashi, Kiyotaka Kawai, Muneyasu Kiriyama
A 62-year-old man was diagnosed with liver metastasis of sigmoid colon cancer, which resulted in bowel obstruction. SOX plus bevacizumab therapy was administered to perform hepatectomy, after the artificial anus construction; however, substantial liver dysfunction occurred. Therefore, we only performed primary tumor resection and waited for improvement in liver function. After 2 months, liver function improved and liver metastasis increased. However, another metastasis was not recognized, so hepatectomy was carried out, and R0 resection was performed...
June 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Omar Abdel-Rahman
OBJECTIVE: The aim of the current study is to evaluate the performance characteristics of the National Comprehensive Cancer Network (NCCN) staging recommendations for breast cancer with regard to the detection of lung, bone, and liver metastases. METHODS: Surveillance, epidemiology, and end points (SEER) database (2010-2015) was accessed, and patients with breast cancer and complete information about T stage and clinical N stage, ER status, Her2 status, and metastatic sites were extracted...
November 2018: Breast Cancer Research and Treatment
Anick Nater, Lindsay A Tetreault, Branko Kopjar, Paul M Arnold, Mark B Dekutoski, Joel A Finkelstein, Charles G Fisher, John C France, Ziya L Gokaslan, Laurence D Rhines, Peter S Rose, Arjun Sahgal, James M Schuster, Alexander R Vaccaro, Michael G Fehlings
BACKGROUND: This study was designed to identify preoperative predictors of survival in surgically treated patients with metastatic epidural spinal cord compression (MESCC), to examine how these predictors are related to 8 prognostic models, and to perform the first full external validation of these models in accordance with the Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD) statement. METHODS: One hundred forty-two surgically treated patients with MESCC were enrolled in a prospective, multicenter North American cohort study and were followed for 12 months or until death...
September 1, 2018: Cancer
Stephan Marquardt, Manish Solanki, Alf Spitschak, Julio Vera, Brigitte M Pützer
Metastasis is one of the most challenging issues in cancer patient management, and effective therapies to specifically target disease progression are missing, emphasizing the urgent need for developing novel anti-metastatic therapeutics. Cancer stem cells (CSCs) gained fast attention as a minor population of highly malignant cells within liquid and solid tumors that are responsible for tumor onset, self-renewal, resistance to radio- and chemotherapies, and evasion of immune surveillance accelerating recurrence and metastasis...
June 30, 2018: Seminars in Cancer Biology
Michael L Drummond, Mischa Li, Eric Tarapore, Tuyen T L Nguyen, Baina J Barouni, Shaun Cruz, Kevin C Tan, Anthony E Oro, Scott X Atwood
Primary cilia are polarized organelles that allow detection of extracellular signals such as Hedgehog (Hh). How the cytoskeleton supporting the cilium generates and maintains a structure that finely tunes cellular response remains unclear. Here, we find that regulation of actin polymerization controls primary cilia and Hh signaling. Disrupting actin polymerization, or knockdown of N-WASp/Arp3, increases ciliation frequency, axoneme length, and Hh signaling. Cdc42, a potent actin regulator, recruits both atypical protein pinase C iota/lambda (aPKC) and Missing-in-Metastasis (MIM) to the basal body to maintain actin polymerization and restrict axoneme length...
September 3, 2018: Journal of Cell Biology
Nikolas G Balanis, Thomas G Graeber
Lethal cancers have genomes that can reflect a jigsaw puzzle put together in a hurricane. The missing, misjoined, and extra pieces contribute to the driving forces behind the cancer phenotypes. But is this the only reason genomic instability is so prevalent in aggressive cancers? New findings support that the hurricane winds themselves, not just their aftermath, contribute to the cancer phenotype of metastasis.
July 2018: Trends in Cancer
Dong Young Jeong, Min Yeong Kim, Kyung Soo Lee, Joon Young Choi, Soo Jeong Kim, Myung Jin Chung, Yang Won Min, Hong Kwan Kim, Jae Ill Zo, Young Mog Shim, Jong-Mu Sun
This study aimed to evaluate the frequency of nodal metastases and to disclose the diagnostic performance of endoscopic ultrasonography (EUS) and PET/CT in T and N staging in surgically resected early-stage esophageal squamous cell carcinomas (eSCCs). Institutional review board approved this retrospective study with waiver of informed consent for reviewing medical record. We included 435 patients with an early T-stage (Tis or T1a [≤T1a], T1b and T2) eSCC. The rates of metastatic lymphadenopathy were calculated...
August 2018: Cancer Medicine
Litao Yan, Junwei Zong, Jin Chu, Wendong Wang, Mingshu Li, Xianfeng Wang, Mingzhi Song, Shouyu Wang
The calcaneus is a rare location for the occurrence and development of primary tumour types. Clinicians are unfamiliar with calcaneal tumour types, which may result in a delay in diagnosis or a missed diagnosis, resulting in unnecessary morbidity and amputation. Heel pain and localized swelling of the ankle are the most common symptoms. X-ray is the first choice for a tentative diagnosis of a calcaneal tumour. The final diagnosis depends on a histological examination. The treatment of calcaneal tumour types varies depending on the Enneking system...
June 2018: Oncology Letters
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