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Enhance photothermal therapy

Shuyan Yang, Defan Yao, Yanshu Wang, Weitao Yang, Bingbo Zhang, Dengbin Wang
A peptide-modified gold nanoparticle was developed for tumour-targeted therapy. Triggered by alkaline phosphatase, the CREKA-YPFFK(Nph) peptide can self-assemble and further result in accumulation of gold nanoparticles in tumour cells. The large-sized gold nanoparticle aggregates cannot escape from the tumour tissue, therefore realizing the goal of tumour-specific targeting, enhanced retention and photothermal effects.
August 15, 2018: Chemical Communications: Chem Comm
Xichuan Tang, Liwei Tan, Kun Shi, Jinrong Peng, Yao Xiao, Wenting Li, Lijuan Chen, Qian Yang, Zhiyong Qian
Enhancing the heat-sensitivity of tumor cells provides an alternative solution to maintaining the therapeutic outcome of photothermal therapy (PTT). In this study, we constructed a therapeutic system, which was composed of methoxy-polyethylene-glycol-coated-gold-nanorods (MPEG-AuNR) and VER-155008-micelles, to evaluate the effect of VER-155008 on the sensitivity of tumor cells to heat, and further investigate the therapeutic outcome of MPEG-AuNR mediated PTT combined with VER-155008- micelles. VER-155008- micelles down-regulate the expression of heat shock proteins and attenuate the heat-resistance of tumor cell...
July 2018: Acta Pharmaceutica Sinica. B
Yao Lu, Lihua Li, Zefeng Lin, Mei Li, Xiaoming Hu, Yu Zhang, Mingying Peng, Hong Xia, Gang Han
Despite its 5-year event-free survival rate increasing to 60-65% due to surgery and chemotherapy, osteosarcoma (OS) remains one of the most threatening malignant human tumors, especially in young patients. Therefore, a new approach that combines early diagnosis with efficient tumor eradication and bioimaging is urgently needed. Here, a new type of mesoporous silica-coated bismuth sulfide nanoparticles (Bi2 S3 @MSN NPs) is developed. The well distributed mesoporous pores and large surface areas hold great promise for drug protection and encapsulation (doxorubicin (DOX), 99...
August 13, 2018: Advanced Healthcare Materials
Hongrui Zhu, Dui Qin, Youshen Wu, Bowen Jing, Jiajun Liu, David Hazlewood, Hongmei Clara Zhang, Yi Feng, Xinmai Yang, Mingxi Wan, Daocheng Wu
Laser-activated bioprobes with high photothermal conversion efficiency (IRPDA@PFH NDs) based on biocompatible IR-780 doped polydopamine perfluorocarbon nanodroplets were developed. When protected by gelatin microspheres, their near-spherical morphologies can be easily observed with transmission electron microscope. Doping IR-780 (3% w/w of added dopamine hydrochloride) could significantly enhance near-infrared (NIR) absorption and photothermal conversion efficiency to 57.7%. The enhanced NIR absorption and non-radiative relaxation are preferred to stronger photoacoustic (PA) signals and higher PA imaging definition, ultrasound (US) signals also increase more than 2...
August 13, 2018: ACS Applied Materials & Interfaces
Qing-Lan Li, Yao Sun, Li Ren, Xin Wang, Chen Wang, Lin Li, Ying-Wei Yang, Xianghui Yu, Jihong Yu
A smart supramolecular nanosystem integrating targeting, chemotherapy and photothermal therapy, was constructed based on carboxylatopillar[5]arene (CP[5]A)-functionalized CuS nanoparticles (CuS@CP NPs). CuS@CP NPs with good monodispersibility and strong near-infrared absorption were synthesized in aqueous solution through a facile one-pot supramolecular capping method, followed by surface installation of a liver cancer-targeted galactose derivative through host-guest binding interaction. The resulting smart supramolecular nanosystem, namely CuS@CPG, exhibited excellent photothermal ablation capability to HepG2 cells upon irradiation with laser at 808 nm...
August 9, 2018: ACS Applied Materials & Interfaces
Luke Henderson, Oara Neumann, Caterina Kaffes, Runmin Zhang, Valeria Marangoni, Murali K Ravoori, Vikas Kundra, James Bankson, Peter Nordlander, Naomi J Halas
Engineering a compact, near-infrared plasmonic nanostructure with integrated image-enhancing agents for combined imaging and therapy is an important nanomedical challenge. Recently we showed that Au@Si@Au nanomatryoshkas (NM) are a highly promising nanostructure for hosting either T1 MRI or fluorescent contrast agents with a photothermal therapeutic response in a compact geometry. Here we show that a near-infrared-resonant NM can provide simultaneous contrast enhancement for both T1 magnetic resonance imaging (MRI) and fluorescence optical imaging (FOI) by encapsulating both types of contrast agents in the internal silica layer between the Au core and shell...
August 8, 2018: ACS Nano
Caina Xu, Yanbing Wang, Haiyang Yu, Huayu Tian, Xuesi Chen
Low toxic theranostic nanoparticles that can simultaneously achieve effective tumor accumulation and rapid renal clearance are highly desired for imaging contrast agents and photothermal therapy (PTT) in tumor diagnosis and therapy. Herein, we report a one-pot method for preparing multifunctional nanoparticles (FeAP-NPs) based on the coordination interaction of natural polyphenols (anthocyanins) extracted from fruits, FeIII ions, and poly(L-glutamic acid)-g-methoxy poly(ethylene glycol) copolymers. The FeAP-NPs possess the following favorable advantages: (1) The components of FeAP-NPs originate from the natural products, endogenous element, and poly(amino acid) derivatives, guaranteeing their safety for in vivo application...
August 8, 2018: ACS Nano
Xi Yang, Bo Fan, Wei Gao, Liping Li, Tingting Li, Jinghua Sun, Xiaoyang Peng, Xiaoyan Li, Zhenjun Wang, Binquan Wang, Ruiping Zhang, Jun Xie
Background: Effective endosomal escape is still a critical bottleneck for intracellular delivery of small interfering RNAs (siRNAs) to maximize their therapeutic efficacy. To overcome this obstacle, we have developed a photothermally triggered system by using the near-infrared (NIR) irradiation to achieve "on-demand" endosomal escape and subsequent siRNA release into cytoplasm. Materials and methods: Herein, the poly-L-lysine (PLL) was successfully conjugated with melanin to obtain melanin-poly-L-lysine (M-PLL) polymer as a siRNA vehicle...
2018: International Journal of Nanomedicine
Jie Sheng, Beibei Ma, Qian Yang, Chao Zhang, Zhongying Jiang, Entomack Borrathybay
Introduction: In recent years, near-infrared laser-induced photothermal therapy is being considered as a promising approach to kill tumors owing to its noninvasive nature and excellent antitumor efficiency. However, the lack of ideal photothermal agents hinders further development of this technology. Materials and methods: Aiming at solving this long-standing obstacle, we report here about the polyethylene glycol (PEG)-DA modified copper sulfide (CuS) nanoparticles (NPs) (PEG-DA-CuS NPs), a kind of semiconductor photothermal agents that show excellent photothermal stability and high heat conversion efficiency...
2018: International Journal of Nanomedicine
Sheng Wang, Zijian Zhou, Guocan Yu, Nan Lu, Yijing Liu, Yunlu Dai, Xiao Fu, Jing Wang, Xiaoyuan Chen
Accurate diagnosis of tumor is promising to guide photothermal therapy (PTT) for efficacious tumor ablation with minimal damage to healthy tissues. Here we report an activatable dual-modal imaging agent which is based on PEGylated- gadolinium metallofullerene- polypyrrole nanoparticle (PEG-GMF-PPy NP) for imaging-guided PTT. A contrast agent (gadolinium metallofullerene, GMF) with excellent magnetic resonance imaging (MRI) performance and an ultra pH-responsive polymer (PEG-PC7A) are successively modified to the surface of photothermal agent (PPy NP)...
August 7, 2018: ACS Applied Materials & Interfaces
Lirong Wang, Hongyu Lin, Xiaoqin Chi, Chengjie Sun, Jiaqi Huang, Xiaoxue Tang, Hongming Chen, Xiangjie Luo, Zhenyu Yin, Jinhao Gao
The need for better imaging assisted cancer therapy calls for new biocompatible agents with excellent imaging and therapeutic capabilities. This study successfully fabricates albumin-cooperated human serum albumin (HSA)-GGD-ICG nanoparticles (NPs), which are comprised of a magnetic resonance (MR) contrast agent, glycyrrhetinic-acid-modified gadolinium (III)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (GGD), and a fluorescence (FL) dye, indocyanine green (ICG), for multimodal MR/FL imaging assisted cancer therapy...
August 7, 2018: Small
Limin Pan, Jianan Liu, Jianlin Shi
Tumor therapeutic efficacy is determined, to a great extent, by the delivery efficiency of therapeutic drugs to their final targets. The cell nucleus has been proven to be the main interaction site for most therapeutic agents such as anticancer drugs, genes, free radicals, and heat. Therefore, it is highly expected that cell nucleus-targeting or nuclear membrane-penetrating nanotherapeutics would provide a more effective strategy than ordinary cell membrane-targeting ones for benefiting precise nanomedicine in humans' battles against cancer...
July 31, 2018: Chemical Society Reviews
Cuiting Zhang, Jing Li, Chenggen Qian, Xinping Luo, Kaikai Wang, Peixuan Zhao, Minjie Sun
Metal-based photothermal therapy has been widely used in the biomedicine field and includes gold nanoparticles, silver nanoparticles and copper sulfide nanoparticles. Furthermore, the coordination bonding-based metal nanocomplex is a new generation of photothermal agents for cancer therapy due to its high photothermal transduction efficiency, good biocompatibility, biodegradation and bioactivity. In this study, we designed a coordination bonding-based copper (Cu(II))-carboxylate ternary architecture, which consists of a conjugate dopamine-modified nontoxic hyaluronic acid, copper ions and citric acid...
July 2, 2018: International Journal of Pharmaceutics
Hai Wang, Pranay Agarwal, Yutong Liang, Jiangsheng Xu, Gang Zhao, Katherine H R Tkaczuk, Xiongbin Lu, Xiaoming He
Stimuli-responsive nanoparticles hold great promise for drug delivery to improve the safety and efficacy of cancer therapy. One of the most investigated stimuli-responsive strategies is to induce drug release by heating with laser, ultrasound, or electromagnetic field. More recently, cryosurgery (also called cryotherapy and cryoablation), destruction of diseased tissues by first cooling/freezing and then warming back, has been used to treat various diseases including cancer in the clinic. Here we developed a cold-responsive nanoparticle for controlled drug release as a result of the irreversible disassembly of the nanoparticle when cooled to below ∼10 °C...
October 2018: Biomaterials
Milan Gautam, Kishwor Poudel, Chul Soon Yong, Jong Oh Kim
This review outlines recently developed Prussian blue nanoparticle (PB NPs)-based multimodal imaging-guided chemo-photothermal strategies for cancer diagnosis and treatment in order to provide insight into the future of the field. The primary limitation of existing therapeutics is the lack of selectivity in drug delivery: they target healthy and cancerous cells alike. In this paper, we provide a thorough review of diverse synthetic and surface engineering techniques for PB NP fabrication. We have elucidated the various targeting approaches employed to deliver the therapeutic and imaging ligands into the tumor area, and outlined methods for enhancement of the tumor ablative ability of the NPS, including several important combinatorial approaches...
July 24, 2018: International Journal of Pharmaceutics
Xiaodong Zeng, Yuling Xiao, Jiacheng Lin, Shanshan Li, Hui Zhou, Jinxia Nong, Guozhen Xu, Hongbo Wang, Fuchun Xu, Junzhu Wu, Zixin Deng, Xuechuan Hong
The development of novel biodegradable and nontoxic fluorophores that integrate diagnosis and therapy for effective cancer treatment has obtained tremendous attention in the past decades. In this report, water-soluble and biocompatible small-molecule near-infrared II (NIR-II) fluorescent dye H2a-4T complexed with fetal bovine serum (FBS) and Cetuximab proteins with excellent optical properties and targeting ability is prepared. High spatial and temporal resolution imaging of hind limb vasculature and the lymphatic system of living mice using H2a-4T@FBS complex is demonstrated in precise NIR-II imaging-guided sentinel lymph node surgery...
July 26, 2018: Advanced Healthcare Materials
Yesen Li, Jing Ye, Shiyi Zhou, Ruiliang Bai, Guifeng Fu, Weizhong Zhang, Isabel X Zhang, Gang Liu, Fan Zhang, Jin Xie
Nanotransducer-mediated photothermal therapy (PTT) has emerged as an attractive therapy modality against cancer, but its efficacy is often limited by the amount of nanoparticles delivered to tumors. Previous studies showed a vasculature modulation treatment, which dilates or prunes tumor blood vessels, may enhance tumor uptake of nanoparticles. However, exploiting these approaches for improved PTT has seldom been studied. In this study, we investigated the impact of mild hyperthermia or anti-angiogenesis therapy on PTT...
July 23, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Xiaoqing Ren, Yiting Chen, Haibao Peng, Xiaoling Fang, Xiulei Zhang, Qinyue Chen, Xiaofei Wang, Wuli Yang, Xianyi Sha
Autophagy is a conservative eukaryotic pathway which plays a crucial role in maintaining cellular homeostasis, and dysfunction of autophagy is usually associated with pathological conditions. Recently, emerging reports have stressed that various types of nanomaterials and therapeutic approaches interfere with cellular autophagy process, which has brought up concerns to their future biomedical applications. Here, we present a study elaborating the relationships between autophagy and iron oxide nanoparticle (IONP)-mediated photothermal therapy in cancer treatment...
August 9, 2018: ACS Applied Materials & Interfaces
Menglong Zhao, Yunjian Xu, Mingjuan Xie, Liang Zou, Zhaoli Wang, Shujuan Liu, Qiang Zhao
It is always a huge challenge to develop novel near-infrared (NIR) phototherapeutic agents suitable for imaging-guided cancer therapy. In order to clarify the positive heavy atom effects on the photodynamic and photothermal efficiencies of phototherapeutic agents, a series of chlorine-, bromide-, or iodine-substituted aza-BODIPYs (B2, B3, and B4, respectively) are designed and synthesized. Among them, B4 exhibits both excellent photodynamic and photothermal effects (singlet oxygen yield of B4 is 1.57 times more than that of B3) and excellent photothermal effects (1...
July 26, 2018: Advanced Healthcare Materials
Liangcan He, Chenchen Mao, Michael Brasino, Albert Harguindey, Wounjhang Park, Andrew P Goodwin, Jennifer N Cha
Near infrared (NIR)-absorbing noble metal nanostructures are being extensively studied as theranostic agents, in particular for photoacoustic imaging and photothermal therapy. Because of the electric field enhancement at the tips of anisotropic metal nanostructures, positioning photoactive species at these sites can lead to increased energy absorption. Herein, we show the site-specific placement of NIR-active photosensitizers at the ends of gold nanorods (AuNRs) by growing porous TiO2 caps. The surface plasmon resonance of the AuNRs was carefully tuned to overlap with the exciton absorption of indocyanine green (ICG), a NIR photosensitizer with low quantum yields and poor photostability...
August 8, 2018: ACS Applied Materials & Interfaces
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