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Enhance photodynamic therapy

Paula García Calavia, Gordon Bruce, Lluïsa Pérez-García, David A Russell
Gold nanoparticles (AuNPs) have been extensively studied within biomedicine due to their biocompatibility and low toxicity. In particular, AuNPs have been widely used to deliver photosensitiser agents for photodynamic therapy (PDT) of cancer. Here we review the state-of-the-art for the functionalisation of the gold nanoparticle surface with both photosensitisers and targeting ligands for the active targeting of cancer cell surface receptors. From the initial use of the AuNPs as a simple carrier of the photosensitiser for PDT, the field has significantly advanced to include: the use of PEGylated modification to provide aqueous compatibility and stealth properties for in vivo use; gold metal-surface enhanced singlet oxygen generation; functionalisation of the AuNP surface with biological ligands to specifically target over-expressed receptors on the surface of cancer cells and; the creation of nanorods and nanostars to enable combined PDT and photothermal therapies...
August 17, 2018: Photochemical & Photobiological Sciences
Shukun Li, Qianli Zou, Yongxin Li, Chengqian Yuan, Ruirui Xing, Xuehai Yan
Supramolecular photosensitizer nanodrugs that combine the flexibility of supramolecular self-assembly and the advantage of spatiotemporal, controlled drug delivery are promising for dedicated, precise non-invasive tumor therapy. However, integrating robust blood circulation and targeted burst release in a single photosensitizer nanodrug platform that can simultaneously improve the therapeutic performance and reduce side effects is challenging. Herein, we demonstrate a multicomponent coordination self-assembly strategy that is versatile and potent for the development of photodynamic nanodrugs...
August 13, 2018: Journal of the American Chemical Society
Channay Naidoo, Cherie Ann Kruger, Heidi Abrahamse
This review article is based on specifically targeted nanoparticles that have been used in the treatment of melanoma. According to the Skin Cancer Foundation, within 2017 an estimated 9730 people will die due to invasive melanoma. Conventional treatments for nonmalignant melanoma include surgery, chemotherapy, and radiation. For the treatment of metastatic melanoma, 3 therapeutic agents have been approved by the Food and Drug Administration: dacarbazine, recombinant interferon α-2b, and high-dose interleukin 2...
January 1, 2018: Technology in Cancer Research & Treatment
Yanjing Li, Hong Sui, Cailing Jiang, Shumin Li, Yu Han, Peng Huang, Xiaoxue Du, Jingwen Du, Yuxian Bai
BACKGROUND/AIMS: Although photodynamic therapy (PDT) can relieve esophageal obstruction and prolong survival time of patients with esophageal cancer, it can induce nuclear factor-kappa B (NF-κB) activation in many cancers, which plays a negative role in PDT. Dihydroartemisinin (DHA), the most potent artemisinin derivative, can enhance the effect of PDT on esophageal cancer cells. However, the mechanism is still unclear. METHODS: We generated stable cell lines expressing the super-repressor form of the NF-κB inhibitor IκBα and cell lines with lentivirus vector-mediated silencing of the HIF-1α gene...
August 10, 2018: Cellular Physiology and Biochemistry
Vladimir Sheptulin, Konstantine Purtskhvanidze, Johann Roider
PURPOSE: Different modes of photodynamic therapy (PDT) were described for treatment of central serous chorioretinopathy (CSC). The purpose of the current study was to evaluate the outcome of half-time PDT in chronic CSC. METHODS: A retrospective case series study, including 114 eyes of 103 patients with chronic CSC, treated with reduced-fluence PDT. PDT was applied with full-dose verteporfin (6 mg/m2 ) and half-time fluence (43 s). The main outcome measures included timing of complete subretinal fluid (SRF) resolution, recurrences, pre- and post-treatment best-corrected visual acuities (BCVA)...
August 10, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
Hairong Wang, Yu Chao, Jingjing Liu, Wenwen Zhu, Guanglin Wang, Ligeng Xu, Zhuang Liu
Tumor hypoxia is known to be one of critical factors that aggravate the tumor resistance to photodynamic therapy (PDT) in which oxygen is essential for tumor destruction. Herein, catalase, an enzyme to trigger hydrogen peroxide (H2 O2 ) decomposition, is modified by in-situ free radical polymerization, using meso-tetra(p-hydroxyphenyl) porphine (THPP) as the cross-linker to enable condensed grafting of short polyethylene glycol (PEG) chains on the protein surface as a permeable brush-like safeguard. The formulated catalase-entrapped nanocapsules (CAT-THPP-PEG) with enhanced enzyme stability can be labeled with 99m Tc4+ , a radioisotope ion that is chelated by the porphyrin structure of THPP, to allow in vivo single-photon emission computed tomography (SPECT) imaging...
August 4, 2018: Biomaterials
Han Zhang, Kai Liu, Shukun Li, Xia Xin, Shiling Yuan, Guanghui Ma, Xuehai Yan
Minimalist multifunctional platforms for delivering diagnostic and therapeutic agents effectively and safely into tumor sites are highly desired in nanomedicine. Herein, we describe the fabrication of a supramolecular nanoplatform via the amphiphilic amino acid (9-fluorenylmethyloxycarbonyl-L-Leucine, Fmoc-L-L)-modulated self-assembly of a magnetic resonance imaging (MRI) contrast agent (ionic manganese, Mn2+) and photosensitive drug (chlorin e6, Ce6). Coordination drives the coassembly of Fmoc-L-L and Mn2+ to generate a nanoscale supramolecular network to adaptively encapsulate Ce6...
August 9, 2018: ACS Nano
Ke Jiang, Haoran Wang, Huanhuan Zhang, Yiqiao Hu, Jinhui Wu
Near-Infrared (NIR) dyes, with improved tissue penetration, minimal invasiveness and high specificity, have gained great interests in diagnosing and treating tumors. However, the poor solubility in aqueous medium and low 1O2 quantum yields of NIR dyes restrict their application in PDT (photodynamic therapy) research. Herein, a novel nanosystem with modifying the NIR dyes and encapsulating perfluorocarbon is reported for improving the PDT effectiveness of NIR dyes. By adding the PEG2000-SH and the C13 carbon chain to a NIR representative dye IR780, the new formed material PEG-IR780-C13 shows good solubility in water...
July 30, 2018: Cellular and Molecular Biology
Wen Jiang, Ian Michael Delahunty, Jin Xie
Hypoxia is behind tumor resistance in both chemotherapy and photodynamic therapy. This editorial highlights a study by Cai et al. [12] that a hemoglobin and human serum albumin hybrid protein nanoparticle can simultaneously deliver O2 , chemotherapeutics, and photosensitizers to tumors for enhanced chemophototherapy.
2018: Theranostics
Jinkai Ji, Xiao Li, Tiantian Wu, Fude Feng
Reversibly controlled generation of singlet oxygen from photosensitizing nanosystems has the benefits of selective cell killing and controllable effect time, but is a challenging option for photodynamic therapies. We report a strategy for integrating photochromic spiropyrans into biocompatible cationic polymers, which involved assembling nucleic acids into functional nanoparticles without introducing additional photosensitizers and imaging agents. We found that spiropyran-containing nanoparticles have photoswitching properties for both fluorescence (with a quantum yield of up to 0...
July 14, 2018: Chemical Science
Xinyi Lin, Ming Wu, Ming Li, Zhixiong Cai, Haiyan Sun, Xionghong Tan, Jiong Li, Yongyi Zeng, Xiaolong Liu, Jingfeng Liu
The development of multifunctional carriers incorporating genetic and photodynamic therapy (PDT) for synergistic antitumor treatment has attracted intensive interests very recently. However, most of the currently reported systems employ passive gene release strategies depending on tumor microenvironment, which are negatively affected by the heterogeneity of cancer cells, thus resulting in limited controllability in therapeutic progress. Herein, a novel photo-responsive hollow silica nanoparticle (HNP)-based gene and photosensitizer (PS) co-delivery nanovehicle is designed for dual-wavelength light-triggered synergistic gene and PDT therapy...
August 2018: Acta Biomaterialia
Azadeh Golmohamadpour, Bahram Bahramian, Mehdi Khoobi, Maryam Pourhajibagher, Hamid Reza Barikani, Abbas Bahador
BACKGROUND: Antimicrobial photodynamic therapy (aPDT) has been emerged as one of the promising non-invasive adjuvant for the treatment of endodontic infections. The key part of this technique is application of an optimized nontoxic photosensitizer (PS), like indocyanine green (ICG) activated by light source destroying bacterial contaminants. Notwithstanding all featured properties of ICG, this PS mainly suffers from the lack of stability and concentration-dependent aggregation. A variety of nanomaterials (NMs) has been widely exploited to improve the stability and efficiency of ICG...
August 2, 2018: Photodiagnosis and Photodynamic Therapy
Xin Mu, Li Wang, Lijuan Wang, Rui Ge, Haiqiang Dang, Kuanhou Mou
BACKGROUND/PURPOSE: Basal cell carcinoma (BCC) often occurs in the face of middle and old aged people. Given its particular location, aminolevulinic acid-photodynamic therapy (ALA-PDT) is often applied in cosmetology and inappropriate surgical treatment. Specific measures in PDT treatment should be performed to increase the ALA penetration capability because of the limited depth of ALA penetration. This research aims to explore the method that facilitates ALA penetration. METHODS: Three patients with BCC were subjected to four regular sessions of ALA-PDT every other week...
August 2, 2018: Photodiagnosis and Photodynamic Therapy
Jieling Li, Anhe Wang, Luyang Zhao, Qianqian Dong, Meiyue Wang, Haolan Xu, Xuehai Yan, Shuo Bai
Employing nanoscaled materials as photosensitizer (PS) carriers is an effective strategy to solve the problem of poor solubility and low tumor selectivity of hydrophobic PS in photodynamic therapy (PDT), which compulsorily requires the PS release in PDT implementation. However, the complicated environment in vivo makes it difficult to precisely design and control the release process and the delivery process requires real-time tracking. Developing a delivery strategy of hydrophobic PS in the monomeric form with fluorescent emission and without consideration of the PS release in the PDT process, is in urgent demand...
August 15, 2018: ACS Applied Materials & Interfaces
Xiuhua Wang, Lei Tan, Xiangmei Liu, Zhenduo Cui, Xianjin Yang, Kelvin W K Yeung, Paul K Chu, Shuilin Wu
Near infrared (NIR) light induced photodynamic antibacterial therapy (PDAT) is a promising antibacterial technique in rapid in situ disinfection of bacterially infected artificial implants due to its penetration ability into tissues. However, the lower oxygen content in vivo may restrict the yields of reactive oxygen species (ROS), thus reducing the antibacterial efficacy of PADT significantly. Herein, liposome encapsulated photosensitizers (PS), IR780 and perfluorohexane (PFH), have been constructed on the surface of Ti implants via a covalent linkage to overcome this issue...
August 1, 2018: Biomaterials Science
Fang Hu, Shidang Xu, Bin Liu
Photodynamic therapy is arising as a noninvasive treatment modality for cancer and other diseases. One of the key factors to determine the therapeutic function is the efficiency of photosensitizers (PSs). Opposed to traditional PSs, which show quenched fluorescence and reduced singlet oxygen production in the aggregate state, PSs with aggregation-induced emission (AIE) exhibit enhanced fluorescence and strong photosensitization ability in nanoparticles. Here, the design principles of AIE PSs and their biomedical applications are discussed in detail, starting with a summary of traditional PSs, followed by a comparison between traditional and AIE PSs to highlight the various design strategies and unique features of the latter...
July 31, 2018: Advanced Materials
Limin Pan, Jianan Liu, Jianlin Shi
Tumor therapeutic efficacy is determined, to a great extent, by the delivery efficiency of therapeutic drugs to their final targets. The cell nucleus has been proven to be the main interaction site for most therapeutic agents such as anticancer drugs, genes, free radicals, and heat. Therefore, it is highly expected that cell nucleus-targeting or nuclear membrane-penetrating nanotherapeutics would provide a more effective strategy than ordinary cell membrane-targeting ones for benefiting precise nanomedicine in humans' battles against cancer...
July 31, 2018: Chemical Society Reviews
Mathias Viard, Henry Reichard, Bruce A Shapiro, Farukh A Durrani, Aimee J Marko, R Michelle Watson, Ravindra K Pandey, Anu Puri
Advances in in vivo stability and preferential tumor uptake of cancer nanomedicine are warranted for effective chemotherapy. Here, we describe a novel nanoformulation using an unconventional polymeric tubule-forming phospholipid, DC8,9 PC. We report that DC8,9 PC transitions to stable vesicles (LNPs) in the presence of PEGylated lipid (DSPE-PEG2000); the resulting DC8,9 PC:DSPE-PEG2000 LNPs efficiently included a hydrophobic PDT drug, HPPH. Remarkably, these LNPs incorporated unusually high DSPE-PEG2000 concentrations; LNP10 -HPPH and LNP20 -HPPH (10 & 20 mol% PEGylated lipid, respectively) exhibited >90% serum stability at 37 °C...
July 27, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
Han Wang, Bin Lv, Zhongmin Tang, Meng Zhang, Weiqiang Ge, Yanyan Liu, Xinhong He, Kuaile Zhao, Xiangpeng Zheng, Mingyuan He, Wenbo Bu
X-ray-induced photodynamic therapy (X-PDT) has high depth of penetration and has considerable potential for applications in cancer therapy. Scintillators and heavy metals have been adopted to absorb X-rays and transmit the energy to photosensitizers. However, the low efficiency of converting X-rays to reactive oxygen species (ROS) presents a challenge for the use of X-PDT to cure cancer. In this study, a new method based on LiLuF4 :Ce@SiO2 @Ag3 PO4 @Pt(IV) nanoparticles (LAPNP) is presented that could be used to enhance the curative effects of X-PDT...
July 31, 2018: Nano Letters
Menglong Zhao, Yunjian Xu, Mingjuan Xie, Liang Zou, Zhaoli Wang, Shujuan Liu, Qiang Zhao
It is always a huge challenge to develop novel near-infrared (NIR) phototherapeutic agents suitable for imaging-guided cancer therapy. In order to clarify the positive heavy atom effects on the photodynamic and photothermal efficiencies of phototherapeutic agents, a series of chlorine-, bromide-, or iodine-substituted aza-BODIPYs (B2, B3, and B4, respectively) are designed and synthesized. Among them, B4 exhibits both excellent photodynamic and photothermal effects (singlet oxygen yield of B4 is 1.57 times more than that of B3) and excellent photothermal effects (1...
July 26, 2018: Advanced Healthcare Materials
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