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Experimental burn

Patricia Brassolatti, Paulo Sérgio Bossini, Hueliton Wilian Kido, Maria Carolina Derencio Oliveira, Luciana Almeida-Lopes, Lisinéia Maria Zanardi, Marcos Aurélio Napolitano, Lucimar Retto da Silva de Avó, Fernando M Araújo-Moreira, Nivaldo Antonio Parizotto
Burns are injuries caused mainly by thermal trauma, which can progress to unsatisfactory results healing. This study aimed to evaluate the biomaterial (bacterial cellulose membrane) and photobiomodulation, exclusively and associated, in the treatment of third degree burns in rats. Forty male Wistar rats (±280 g) were randomly divided into four groups, with 10 animals each: control group (CG); bacterial cellulose membrane group (MG); laser group (LG) and bacterial cellulose membrane and laser group (MG + L)...
October 4, 2018: Journal of Tissue Viability
Amber L Harris Bozer, Ai-Ling Li, Perry N Fuchs, Yuan B Peng
BACKGROUND: Neuropathic pain patients have described experiencing unprovoked, intermittent pain attacks with shooting, stabbing, and burning qualities. Rodent models used in previous literature usually only involve acute exposure, and/or are unable to manipulate the stimulation intensity in vivo by the experimenter during an experiment. NEW METHOD: This paper describes a method to induce controllable pain behaviors in rodents using a wireless portable electronic device that can be manipulated within the course of an experiment...
October 10, 2018: Journal of Neuroscience Methods
Latika Rohilla, Meenakshi Agnihotri, Sukhpal Kaur Trehan, Ramesh Kumar Sharma, Sandhya Ghai
The effectiveness of music therapy for relieving pain and anxiety during burn dressing changes has not been reported from India. PURPOSE: This study was conducted to assess the effect of music therapy on pain, anxiety, opioid use, and hemodynamic variables during burn dressing change. METHODS: Patients in a tertiary care burn unit who were >10 years old, conscious, able to respond, and oriented to time, place, and person participated in a 2-month, quasi-experimental, cross-over pilot study...
October 2018: Ostomy/wound Management
Parisa Taheri, Saeid Khosrawi, Mahsa Mazaheri, Mehrdad Adib Parsa, Arghavan Mokhtarian
Background: Pathologic scarring is a common problem after burn injury that has functional and esthetic limitations. Conservative and surgical treatments available for these scars are not always satisfactory. Extracorporeal shock wave therapy (ESWT) is a noninvasive modality that has proven positive effects on burn scars and wound healing in few studies. This study was conducted to evaluate the effects of ESWT on improving burn scar in extremities. Materials and Methods: This study was a prospective quasi-experimental on burn patients with burn scar in their extremities that underwent ESWT sessions once a week for 6 weeks...
2018: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
Lisa Wrba, J Josephine Ohmann, Philipp Eisele, Shinjini Chakraborty, Sonja Braumüller, Christian K Braun, Bettina Klohs, Anke Schultze, Heike von Baum, Annette Palmer, Markus Huber-Lang, Rebecca Halbgebauer
Dysfunction of the gut-blood barrier plays an important role in many diseases, such as inflammatory bowel disease, hemorrhagic shock (HS) or burn injury. However, little is known about gut barrier dysfunction after hemodynamically instable polytrauma (PT). Therefore, we aimed to evaluate the effects of PT and HS on remote intestinal damage and barrier dysfunction, especially regarding the role of Zonula occludens protein 1 (ZO-1) as an important tight junction protein.Male C57BL/6 mice were subjected to either PT (thorax trauma, closed head injury, soft tissue injury and distal femoral fracture), 60 min of pressure-controlled HS (30 ± 5 mmHg), or PT+HS, or sham procedures...
October 4, 2018: Shock
Jinyong Ju, Du Yu, Feng Xue, Yong Zhao, Weizhe Shi, Mingmang Pan, Guo Tang, Haijun Xiao
PURPOSE: To investigate the pathogenesis and find a better prophylactic method of acquired heterotopic ossification (HO). MATERIALS AND METHODS: In the first part, we designed the brain-traumatic/burn/tenotomy rat model and testified its efficacy as HO model. 44 rats were randomly divided into experimental group and control group. After operation, the bilateral tendons of 2 rats were collected at the 2nd , 3rd , 4th , 6th , 8th , and 10th weeks to determine the expression levels of p65...
October 10, 2018: Connective Tissue Research
I Saputro, B Riestiano, L T Hoekstra, L Zarasade
BACKGROUND: Electric burn patients usually suffer permanent injury and sequelae. Salvage of the zone of stasis is an important topic in the treatment of burn patients. N-Acetylcysteine (NAC), as an antioxidant, has effect on the saving zone of stasis and extensive rhabdomyolisis. The aim of this study was therefore to evaluate the effect of oral NAC on tissue destruction indicators in an electric burn rat model. MATERIAL AND METHODS: An experimental study was conducted with thirty six male Wistar albino rats divided into 2 groups...
September 28, 2018: Burns: Journal of the International Society for Burn Injuries
Yan Zhao, Yinghui Jin, Jiayu Hao, Yonggang Yang, Lirong Wang, Changyong Li, Suotang Jia
The resonance enhanced multiphoton ionization (REMPI), ultraviolet-ultraviolet (UV-UV) hole burning and mass analyzed threshold ionization (MATI) spectroscopy have been applied to investigate the vibrational features of p‑isopropylphenol in its first electronically excited state S1 and cationic ground state D0 . Two stable conformational structures of p‑isopropylphenol are distinctly found in the supersonic molecular beam and identified as the cis and trans rotamers through REMPI and UV-UV hole burning spectroscopy...
September 10, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Yoshitaka Matsuura, Kazuo Noda, Shigehiko Suzuki, Katsuya Kawai
The wounds of full- and deep partial-thickness burns result in hypertrophic scars and lead to skin contracture more severely than those of superficial partial-thickness burns. Therefore, preventing burn progression may help improve the aesthetic and functional outcomes after healing. Although a number of studies have focused on elucidating the underlying mechanisms of and preventing burn wound progression, it is still difficult to rescue burned dermis unless early tangential excision is performed. To investigate the underlying mechanisms of and prevent cell death of heat-injured fibroblasts, we developed an in vitro experimental model of heat-injured fibroblasts...
September 22, 2018: Burns: Journal of the International Society for Burn Injuries
B Cheng, T J T Kwan, S A Yi, O L Landen, Y M Wang, C J Cerjan, S H Batha, F J Wysocki
Asymmetric implosion of inertial confinement fusion capsules is known, both experimentally and computationally, to reduce thermonuclear performance. This work shows that low-mode asymmetries degrade performance as a result of a decrease in the hydrodynamic disassembly time of the hot-spot core, which scales with the minimum dimension of the hot spot. The asymmetric shape of a hot spot results in decreased temperatures and areal densities and allows more alpha particles to escape, relative to an ideal spherical implosion, thus reducing alpha-energy deposition in the hot spot...
August 2018: Physical Review. E
Meltem Yildirim, Ecem Koroglu, Cagla Yucel, Senay Kirlak, Sevim Sen
BACKGROUND AND AIM: Pediatric burn injury is a traumatic experience which affects the child both physically and psychologically. Following the burn injury, repetitive dressing changes are one of the main problems, and to manage the level of distress caused this procedure, various distraction strategies are being used. However, the effect of hospital clown during burn dressing change among children has not been studied before. Therefore, the present study aimed to investigate the effect of hospital clown-nurse on children's compliance to burn dressing change...
September 21, 2018: Burns: Journal of the International Society for Burn Injuries
Ivan Phelan, Penny J Furness, Orla Fehily, Andrew R Thompson, Nathan T Babiker, Martin A Lamb, Shirley A Lindley
Burns patients often suffer excruciating pain during clinical procedures, even with analgesia. Virtual Reality as an adjunct to pharmacological therapy has proved promising in the management of burn pain. More evidence is needed regarding specific forms of Virtual Reality. This mixed-method study examined the impact of active and passive Virtual Reality scenarios in experimental conditions, gathering data relating to user experience, acceptability and effectiveness in managing pain. Four scenarios were developed or selected following a consultative workshop with burns survivors and clinicians...
September 21, 2018: Journal of Burn Care & Research: Official Publication of the American Burn Association
Michal Košťál, Vojtěch Rypar, Evžen Losa, David Harut, Martin Schulc, Vít Klupák, Zdeněk Matěj, František Cvachovec, Bohumil Jánský, Evžen Novák, Tomáš Czakoj, Vlastimil Juříček, Sergey Zaritsky
The neutron flux distribution behind a reactor pressure vessel (RPV) is an important parameter that is monitored to determine neutron fluence in the RPV. Together with mechanical testing of surveillance specimens, these are the most important parts of in-service inspection programs that are essential for a realistic and reliable assessment of the RPV residual lifetime. The fast neutron fluence values are determined by a calculation. These calculation results are accompanied by measurements of induced activities of the activation foils placed in the capsules behind the RPV at selected locations, namely in azimuthal profile...
September 7, 2018: Applied Radiation and Isotopes
Gianmaria Pio, Ernesto Salzano
Natural gas represents an attractive fuel for industrialized and developing countries seeking an alternative to petroleum. Due to economic and safety considerations, liquefied natural gas (LNG) at cryogenic conditions is preferred for storage and transportation. The main drawback is the poor understanding of the physical and chemical phenomena that occur at the storage conditions of liquid methane, i.e. at ultra-low temperatures around 110 K and, if released, at temperatures below ambient. In this work, a procedure to evaluate the laminar burning velocity, the flammability limit (FL) and the limiting oxygen concentration (LOC) of methane-air-diluent mixtures based on detailed kinetic mechanism at ultra-low temperatures is proposed...
January 15, 2019: Journal of Hazardous Materials
Francisco Lucas A Batista, Luiza M G Lima, Izamar A Abrante, José Ismael F de Araújo, Francisca Leidivania A Batista, Izabel A Abrante, Erlândia A Magalhães, Daniele R de Lima, Maria da Conceição L Lima, Brenda Silva do Prado, Luiz F W G Moura, Maria Izabel F Guedes, Maria Kueirislene A Ferreira, Jane Eire Silva Alencar de Menezes, Sacha Aubrey A R Santos, Francisco Rogênio S Mendes, Renato A Moreira, Ana Cristina O Monteiro-Moreira, Adriana R Campos, Francisco Ernani A Magalhães
Neem fruit (Azadirachta indica A. Juss.) are popularly used to treat infections, diarrhea, fever, bronchitis, skin diseases, infected burns and hypertension. Although the antinociceptive and anti-inflammatory potential of A. indica has already been investigated in experimental models of pain and inflammation in mice, the current research is the first to report the evaluation of the capacity of A. indica fruit ethanolic extract (EtFrNeem) in acute pain attenuation using the adult zebrafish (Danio rerio) as an alternative model to the use in rodents...
September 17, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Sarah M Ludwig, Heather D Alexander, Knut Kielland, Paul J Mann, Susan M Natali, Roger W Ruess
Fire frequency and severity are increasing in tundra and boreal regions as climate warms, which can directly affect climate feedbacks by increasing carbon (C) emissions from combustion of the large soil C pool and indirectly via changes in vegetation, permafrost thaw, hydrology, and nutrient availability. To better understand the direct and indirect effects of changing fire regimes in northern ecosystems, we examined how differences in soil burn severity (i.e., extent of soil organic matter combustion) affect soil C, nitrogen (N), and phosphorus (P) availability and microbial processes over time...
September 19, 2018: Global Change Biology
Carlos Alberto Ocon, Solange Almeida Dos Santos, Jheniphe Rocha Caires, Marcelo Ferreira Duarte de Oliveira, Andrey Jorge Serra, Ernesto Cesar Leal-Junior, Paulo de Tarso Camillo de Carvalho
This systematic review was performed to identify the role of photobiomodulation therapy in experimental models of third-degree burns used to induce oxidative stress. EMBASE, PubMed, and CINAHL databases were searched for studies published between January 2003 and January 2018 on the topics of photobiomodulation therapy and third-degree burns. Any study that assessed the effects of photobiomodulation therapy in animal models of third-degree burns was included in the analysis. A total of 17 studies were selected from 1182 original articles targeted on photobiomodulation therapy and third-degree burns...
September 18, 2018: Lasers in Medical Science
Huan Tang, Ikuo Yonemitsu, Yuhei Ikeda, Kenzo Watakabe, Shunichi Shibata, Jun Hosomichi, Ono Takashi
OBJECTIVES: Mouth breathing caused by nasal obstruction (owing to abnormal pressure of masticatory muscles) affects craniofacial growth and development. The influence of unilateral nasal obstruction on jaw-closing muscles was investigated in rats to reveal one of the etiologic mechanisms. MATERIALS AND METHODS: Forty 8-day-old male Wistar rats were used in this study. Experimental rats were subjected to left-sided nasal obstruction by burning the external nostril tissue at the age of 8 days...
September 17, 2018: Angle Orthodontist
Nicholas A Moore, James S Camac, John W Morgan
It remains uncertain how perennial grasses with different photosynthetic pathways respond to fire, and how this response varies with stress at the time of burning. Resprouting after fire was examined in relation to experimentally manipulated pre-fire watering frequencies. We asked the following questions: are there response differences to fire between C3 and C4 grasses? And, how does post-fire resprouting vary with pre-fire drought stress? Fifty-two perennial Australian grasses (37 genera, 13 tribes) were studied...
September 14, 2018: New Phytologist
I Lknur Kahriman, Havva Karadeniz
Pediatric injuries pose a significant problem, both in Turkey and worldwide, because they lead to death or disability in a number of children each year. This quasi-experimental study aimed to identify the effects of the training provided to mothers with children aged 0-6 years about the hazards that lead to pediatric injuries. The population of the research comprised mothers with children aged 0-6 years, living in the city center. Considering the educational and socioeconomic levels of the individuals registered in the family health centers (FHC), the FHCs were divided into 3 groups of high, moderate, and low socioeconomic level...
September 2018: Journal of Trauma Nursing: the Official Journal of the Society of Trauma Nurses
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