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Experimental burn

Zahra Paymaneh, Milan Gryndler, Tereza Konvalinková, Oldřich Benada, Jan Borovička, Petra Bukovská, David Püschel, Veronika Řezáčová, Mehdi Sarcheshmehpour, Jan Jansa
Biochar has been heralded as a multipurpose soil amendment to sustainably increase soil fertility and crop yields, affect soil hydraulic properties, reduce nutrient losses, and sequester carbon. Some of the most spectacular results of biochar (and organic nutrient) inputs are the terra preta soils in the Amazon, dark anthropogenic soils with extremely high fertility sustained over centuries. Such soil improvements have been particularly difficult to achieve on a short run, leading to speculations that biochar may need to age (weather) in soil to show its best...
2018: Frontiers in Microbiology
Sara Javanmardi, Amaneh Ghojoghi, Baharak Divband, Javad Ashrafi
INTRODUCTION: Over the past few decades, the application of nanotechnology has gained progressive interest for the regeneration of injured and burned tissues. OBJECTIVE: This study evaluates the effects of titanium dioxide (TiO₂) nanoparticle (NP)/gelatin on burn wound healing in mice. MATERIALS AND METHODS: Sixty healthy male BALB/c mice with a full-thickness burn wound were randomized into 4 experimental groups of 15 animals each: (1) control group was treated with normal saline; (2) gelatin group was treated with gelatin-based ointment; (3) silver sulfadiazine group was treated with silver sulfadiazine 1% ointment; and (4) TiO₂ NP/gelatin group (TNG) received TiO₂ NP/gelatin...
December 2018: Wounds: a Compendium of Clinical Research and Practice
Ivo Laidmäe, Kaspars Ērglis, Andrejs Cēbers, Paul A Janmey, Raivo Uibo
3D fibrous scaffolds have received much recent attention in regenerative medicine. Use of fibrous scaffolds has shown promising results in tissue engineering and wound healing. Here we report the development and properties of a novel fibrous scaffold that is useful for promoting wound healing. A scaffold made of salmon fibrinogen and chitosan is produced by electrospinning, resulting in a biocompatible material mimicking the structure of the native extracellular matrix (ECM) with suitable biochemical and mechanical properties...
November 30, 2018: Journal of Materials Science. Materials in Medicine
Debajyoti Ray, Sanjay K Ghosh, Sibaji Raha
The present experimental study describes the characteristics of polycyclic aromatic hydrocarbons (PAHs) emitted with PM2.5 particles during wood and rice straw burning as well as impacts of photochemical ageing on the half lives of particulate PAHs and their diagnostic ratio values. The photochemical degradation kinetics experiments were carried out by exposing the PM2.5 to light and synthetic air flow. Pseudo first order rate constants were calculated based on PAH loss as a function of exposure time. Relatively quick degradation of lighter PAHs (3-rings) [(0...
November 22, 2018: Journal of Hazardous Materials
Stavros-Loukas Karamatsoukis, Eleni-Andriana Trigka, Marianna Stasinopoulou, Antigoni Stavridou, Argyro Zacharioudaki, Kalliopi Tsarea, Maria Karamperi, Theodoros Pittaras, Othon Papadopoulos, Efstratios Patsouris, Nikolaos Nikiteas, Georgios C Zografos, Apostolos E Papalois
PURPOSE OF THE STUDY: Tissue reconstruction after burns, tumor excisions, infections or injuries is a frequent surgical challenge to avoid Ischemia-reperfusion injury. Lazaroids and sildenafil, through their mechanisms of action, have been studied for their protective effects on various organs subjected to IRI. In this study, we aimed to evaluate the therapeutic potential of U-74389G and sildenafil in a swine model of ischemia and reperfusion injury of latissimus dorsi flap. MATERIALS AND METHODS: Forty-two Landrace male pigs, weighing 28-35 kg, were equally (n = 6) randomized into the following groups: (a) Group I: control, (b) Group II: administration of U-74389G after ischemia, (c) Group III: administration of sildenafil after ischemia, (d) Group IV: administration of U-74389G and sildenafil after ischemia, (e) Group V: administration of U-74389G prior to ischemia, (f) Group VI: administration of sildenafil prior to ischemia, and (g) Group VII: administration of U-74389G and sildenafil prior to ischemia...
November 30, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
Ali R Ahmadi, Maria Chicco, Jinny Huang, Le Qi, James Burdick, George M Williams, Andrew M Cameron, Zhaoli Sun
INTRODUCTION: Severe burns are often associated with high morbidity and unsatisfactory functional and esthetic outcomes. Over the last two decades, stem cells have generated great hopes for the treatment of numerous conditions including burns. The aim of this systematic review is to evaluate the role of stem cell therapy as a means to promote burn wound healing. METHODS: Comprehensive searches in major databases were carried out in March 2017 for articles on stem cell therapy in burn wound healing...
November 26, 2018: Burns: Journal of the International Society for Burn Injuries
Richard E Heyman, Cary S Kogan, Heather M Foran, Samantha C Burns, Amy M Smith Slep, Alexandra K Wojda, Jared W Keeley, Tahilia J Rebello, Geoffrey M Reed
Background/Objective: Intimate partner relationship problems and intimate partner abuse and neglect - referred to in this paper as "relational problems and maltreatment" - have substantial and well-documented impact on both physical and mental health. However, classification guidelines, such as those found in the International Classification of Diseases (ICD-10), are vague and unlikely to support consistent application. Revised guidelines proposed for ICD-11 are much more operationalized. We used standardized clinical vignette conditions with an international panel of clinicians to test if ICD-11 changes resulted in improved classification accuracy...
May 2018: International Journal of Clinical and Health Psychology: IJCHP
A M Saifullah, F Ahmed, B C Shil, R K Banik, S K Saha, M Chowdhury, A Haque, M S Alam, A Akhter
Gastroesophageal reflux disease is widely reported most prevalent disease of the gastrointestinal tract. The burden of gastroesophageal reflux disease (GERD) is increasing in Asia and the majority of patients have non-erosive reflux disease. This prospective, open label, non random (consecutive), experimental study was performed due to compare the therapeutic efficacy of alginate and omeprazole in relieving symptoms of non erosive reflux disease (NERD) and was carried out in the Outpatient Department of Gastroenterology, Dhaka Medical College Hospital, Dhaka, Bangladesh from December 2013 to May 2014...
October 2018: Mymensingh Medical Journal: MMJ
Tracy Petrie, Ravikant Samatham, Alexander M Witkowski, Andre Esteva, Sancy A Leachman
Innovative technologies, including novel communication and imaging tools, are affecting dermatology in profound ways. A burning question for the field is whether we will retrospectively react to innovations or proactively leverage them to benefit precision medicine. Early detection of melanoma is a dermatologic area particularly poised to benefit from such innovation. This session of the Montagna Symposium on Biology of Skin focused on provocative, potentially disruptive advances, including crowdsourcing of patient advocacy efforts, rigorous experimental design of public education campaigns, research with mobile phone applications, advanced skin imaging technologies, and the emergence of artificial intelligence as a diagnostic supplement...
October 25, 2018: Journal of Investigative Dermatology
Y H Sun
In 1958, with the national steelmaking, the number of burn victims greatly increased. With general surgery, trauma, and plastic surgeons as the core, a burn rescue group formed through multi-disciplinary cooperation, which gradually developed into an independent discipline. With great love and responsibility, the vast number of medical and nursing staff of burn discipline learned and discussed in practice, who were constantly improving and daring to break through and innovate. At that time, Qiu Caikang, the steel-making worker, with 89% total body surface area (TBSA) of total burn area and 23% TBSA of full-thickness burn, was rescued in Shanghai Guangci Hospital (now known as Ruijin Hospital, Shanghai Jiao Tong University School of Medicine), which was the first to succeed, rewriting the world record, followed by successful reports from hospitals in Chongqing, Xi'an, Beijing, and other places...
November 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
Jeffrey D Einkauf, Andrew J Wilcox, Jonathan D Burns
The dissolution rate and solubility of NaBiO3 have been investigated in nitric acid systems ranging from 4 to 6 M HNO3 and were found to be 58-76 μg/cm2 ·d and 490-830 mM, respectively. The presence of 50 mM U(VI) drastically increased the solubility to 540-1200 mM, while rates of dissolution were relatively unchanged. The solubility of NaBiO3 increased with an increase in U(VI) concentrations at 4 M HNO3 , with log-log analysis indicating a one-to-one complex between Bi and U and infrared spectroscopic evidence monitoring uranyl stretching, suggesting complex formation...
November 26, 2018: Inorganic Chemistry
Gang-Yi Fan, Juin-Hong Cherng, Shu-Jen Chang, Raju Poongodi, Chih-Hsin Wang, Yi-Wen Wang, Yao-Horng Wang, Cheng-Che Liu, En Meng
Wound healing is a dynamic repair process and is the most complex biological process in human life. In response to burn injury, alterations in biological pathways impair the inflammation response, resulting in delayed wound healing. Impaired wound healing frequently occurs in patients with diabetes leading to unfavorable outcomes such as amputation. Hence, dressings having beneficial effect in promoting burn wound repair are needed. However, studies on burn wound treatment are limited due to lack of proper animal models...
November 6, 2018: Journal of Visualized Experiments: JoVE
Andrey Temnov, Tatyana Astrelina, Konstantin Rogov, Boris Moroz, Vladimir Lebedev, Tamara Nasonova, Alla Lyrshchikova, Olga Dobrynina, Yury Deshevoy, Alexander Melerzanov, Augustinus Bader, Apurva Mishra, Shibashish Giri, Valeriy Boyarintsev, Alexander Trofimenko, Andrey Bushmanov, Alexander Samoylov
Background: Mesenchymal stem cells based paracrine bioactive factors that deploy their task as an essential mechanism, but their efficiency for skin regeneration still requires clarification. Methods: The mesenchymal stem cell-based paracrine factors were administered by subcutaneous injection of 0.5 mL peptides (general protein 8 mg/mL). These were performed after radiation on different days like the first, third, sixth, eighth, and 10th. To determine the consequences, we performed photography, planimetry, and preclinical test each week after 15 days of radiation...
2018: Stem Cells and Cloning: Advances and Applications
Ashley N Guillory, Robert P Clayton, Anesh Prasai, Jayson W Jay, Michael Wetzel, Amina El Ayadi, David N Herndon, Celeste C Finnerty
BACKGROUND: It has been previously shown that anesthesia and analgesia can affect outcomes in the rat burn model and that buprenorphine alleviated pain without drastically altering the outcomes of interest. Recently, the use of a sustained release (SR) formulation of buprenorphine has been promoted over conventional buprenorphine. In this study, we assessed whether buprenorphine-SR altered hemodynamic parameters in our rat model of severe burn injury. MATERIALS AND METHODS: Adult male Sprague-Dawley rats were randomized to receive either conventional buprenorphine (0...
December 2018: Journal of Surgical Research
E T Uluer, H S Vatansever, H Aydede, M K Ozbilgin
The skin plays an important role in defending the body against the environment. Treatments for burns and skin injuries that use autologous or allogenic skin grafts derived from adult or embryonic stem cells are promising. Embryonic stem cells are candidates for regenerative and reparative medicine. We investigated the utility of keratinocyte-like cells, which are differentiated from mouse embryonic stem cells, for wound healing using a mouse surgical wound model. Mice were allocated to the following groups: experimental, in which dressing and differentiated cells were applied after the surgical wound was created; control, in which only the surgical wound was created; sham, in which only the dressing was applied after the surgical wound was created; and untreated animal controls with healthy skin...
November 21, 2018: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
Justin Penner, Rashida A Ferrand, Ceri Richards, Kate A Ward, James E Burns, Celia L Gregson
OBJECTIVE: HIV-positive children, adolescents, and young adults are at increased risk poor musculoskeletal outcomes. Increased incidence of vitamin D deficiency in youth living with HIV may further adversely affect musculoskeletal health. We investigated the impact of vitamin D supplementation on a range of musculoskeletal outcomes among individuals aged 0-25 years living with HIV. METHODS: A systematic review was conducted using databases: PubMed/Medline, CINAHL, Web of Knowledge, and EMBASE...
2018: PloS One
Ștefania Marin, Mădălina Georgiana Albu Kaya, Mihaela Violeta Ghica, Cristina Dinu-Pîrvu, Lăcrămioara Popa, Denisa Ioana Udeanu, Geanina Mihai, Marius Enachescu
The aim of this study is to design, develop and evaluate new biohybrid sponges based on polymers (collagen and polyvinyl alcohol) with and without indomethacin as anti-inflammatory drug model to be used for tissue regeneration in wound healing. Type I fibrillar collagen in the form of a gel and different concentrations of polyvinyl alcohol were mixed together to prepare composite gels. Both control samples, without indomethacin and with indomethacin, were obtained. All samples were crosslinked with glutaraldehyde...
November 9, 2018: Pharmaceutics
Dmitrii Glushkov, Kristina Paushkina, Dmitrii Shabardin, Pavel Strizhak, Nadezhda Gutareva
In this work, it has been shown that the involvement of composite fuels in thermal power engineering will enable to recycle both industrial and municipal combustible wastes while saving fossil fuels. The ignition and combustion stability of composite fuel droplets up to their complete burnout was experimentally substantiated under the conditions typical of boiler furnaces, using the example of several fuel compositions with wood, food waste, plastic, and cardboard, each added separately. The values of the guaranteed delay times for the ignition of droplets with a size of about 1 mm were established for the considered fuel compositions in a wide range of the ambient temperature variation (600-1000 °C)...
November 10, 2018: Journal of Environmental Management
Shibashish Giri, Hans-Günther Machens, Augustinus Bader
Injured human skin fails to regenerate, resulting in scar formation. Annually, 100 million new skin-scarring incidents, occurring as a result of surgery, disease, burns, or sports-related damage, remain untreated. Here, we review knowledge gained from scar-free experimental animal models that have natural regenerative mechanisms for scar-free skin recovery. We also focus on the unique role of endogenous stem cells and other cellular and molecular factors, including the balance of the transforming growth factor-beta (TGF-β) pathway in the context of human skin regeneration...
November 5, 2018: Drug Discovery Today
J Figueiredo, A Murari, C Perez Von Thun, D Marocco, M Tardocchi, F Belli, M García Muñoz, A Silva, T Craciunescu, P Blanchard, I Balboa, N Hawkes, I S Carvalho, B Tal, J Bernardo, I Zychor
In order to optimize the scientific exploitation of JET (Joint European Torus) during the upcoming deuterium-tritium experiments, a set of diagnostic systems is being enhanced. These upgrades focus mainly on the experimental and operational conditions expected during tritium campaigns. It should be stressed that measurements relevant for burning plasmas are specifically targeted. Previously non-available capabilities, such as a current measurement system fully covering all poloidal field circuits, are described in detail...
October 2018: Review of Scientific Instruments
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