keyword
https://read.qxmd.com/read/34661196/pericoronary-and-periaortic-adipose-tissue-density-are-associated-with-inflammatory-disease-activity-in-takayasu-arteritis-and-atherosclerosis
#21
JOURNAL ARTICLE
Christopher Wall, Yuan Huang, Elizabeth P V Le, Andrej Ćorović, Christopher P Uy, Deepa Gopalan, Chuoxin Ma, Roido Manavaki, Tim D Fryer, Luigi Aloj, Martin J Graves, Enrico Tombetti, Ben Ariff, Paul Bambrough, Stephen P Hoole, Rosemary A Rusk, David R Jayne, Marc R Dweck, David Newby, Zahi A Fayad, Martin R Bennett, James E Peters, Piotr Slomka, Damini Dey, Justin C Mason, James H F Rudd, Jason M Tarkin
Aims: To examine pericoronary adipose tissue (PCAT) and periaortic adipose tissue (PAAT) density on coronary computed tomography angiography for assessing arterial inflammation in Takayasu arteritis (TAK) and atherosclerosis. Methods and results: PCAT and PAAT density was measured in coronary ( n = 1016) and aortic ( n = 108) segments from 108 subjects [TAK + coronary artery disease (CAD), n = 36; TAK, n = 18; atherosclerotic CAD, n = 32; matched controls, n = 22]...
September 2021: Eur Heart J Open
https://read.qxmd.com/read/34617993/five-year-outcomes-after-state-of-the-art-percutaneous-coronary-revascularization-in-patients-with-de-novo-three-vessel-disease-final-results-of-the-syntax-ii-study
#22
MULTICENTER STUDY
Adrian P Banning, Patrick Serruys, Giovanni Luigi De Maria, Nicola Ryan, Simon Walsh, Nieves Gonzalo, Robert Jan van Geuns, Yoshinobu Onuma, Manel Sabate, Justin Davies, Maciej Lesiak, Raul Moreno, Ignacio Cruz-Gonzalez, Stephen P Hoole, Jan J Piek, Clare Appleby, Farzin Fath-Ordoubadi, Azfar Zaman, Nicolas M Van Mieghem, Neal Uren, Javier Zueco, Pawel Buszman, Andres Iniguez, Javier Goicolea, David Hildick-Smith, Andrzej Ochala, Dariusz Dudek, Ton de Vries, David Taggart, Vasim Farooq, Ernest Spitzer, Jan Tijssen, Javier Escaned
AIMS: The SYNTAX II study evaluated the impact of advances in percutaneous coronary intervention (PCI), integrated into a single revascularization strategy, on outcomes of patients with de novo three-vessel disease. The study employed decision-making utilizing the SYNTAX score II, use of coronary physiology, thin-strut biodegradable polymer drug-eluting stents, intravascular ultrasound, enhanced treatments of chronic total occlusions, and optimized medical therapy. Patients treated with this approach were compared with predefined patients from the SYNTAX I trial...
March 31, 2022: European Heart Journal
https://read.qxmd.com/read/34409094/current-strategies-for-managing-chronic-thromboembolic-pulmonary-hypertension-results-of-the-worldwide-prospective-cteph-registry
#23
JOURNAL ARTICLE
Stefan Guth, Andrea M D'Armini, Marion Delcroix, Kazuhiko Nakayama, Elie Fadel, Stephen P Hoole, David P Jenkins, David G Kiely, Nick H Kim, Irene M Lang, Michael M Madani, Hiromi Matsubara, Aiko Ogawa, Jaquelina S Ota-Arakaki, Rozenn Quarck, Roela Sadushi-Kolici, Gérald Simonneau, Christoph B Wiedenroth, Bedrettin Yildizeli, Eckhard Mayer, Joanna Pepke-Zaba
BACKGROUND: Pulmonary endarterectomy (PEA), pulmonary arterial hypertension (PAH) therapy and balloon pulmonary angioplasty (BPA) are currently accepted therapies for chronic thromboembolic pulmonary hypertension (CTEPH). This international CTEPH Registry identifies clinical characteristics of patients, diagnostic algorithms and treatment decisions in a global context. METHODS: 1010 newly diagnosed consecutive patients were included in the registry between February 2015 and September 2016...
July 2021: ERJ Open Research
https://read.qxmd.com/read/34303575/serial-right-heart-catheter-assessment-between-balloon-pulmonary-angioplasty-sessions-identify-procedural-factors-that-influence-response-to-treatment
#24
JOURNAL ARTICLE
Karsten P Hug, J Gerry Coghlan, John Cannon, Dolores Taboada, Mark Toshner, Karen Sheares, Alessandro Ruggiero, Nicholas Screaton, David Jenkins, Joanna Pepke-Zaba, Stephen P Hoole
BACKGROUND: Balloon pulmonary angioplasty (BPA) is delivered as a series of treatments for patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) however, there is little published data on the procedural determinants of outcome. METHODS: Pre- and post-BPA clinical and hemodynamic data, as well as serial hemodynamic and procedural data at each BPA session were evaluated to determine patient and procedure-related factors that influence hemodynamic response...
October 2021: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/34187187/adenosine-induced-coronary-steal-is-observed-in-patients-presenting-with-st-segment-elevation-myocardial-infarction
#25
JOURNAL ARTICLE
Muhammad Aetesam-Ur-Rahman, Adam J Brown, Catherine Jaworski, Joel P Giblett, Tian X Zhao, Denise M Braganza, Sarah C Clarke, Bobby S K Agrawal, Martin R Bennett, Nick E J West, Stephen P Hoole
Background Adenosine is used to treat no-reflow in the infarct-related artery (IRA) during ST-segment-elevation myocardial infarction intervention. However, the physiological effect of adenosine in the IRA is variable. Coronary steal-a reduction of blood flow to the distal coronary bed-can occur in response to adenosine and this is facilitated by collaterals. We investigated the effects of adenosine on coronary flow reserve (CFR) in patients presenting with ST-segment-elevation myocardial infarction to better understand the physiological mechanism underpinning the variable response to adenosine...
July 6, 2021: Journal of the American Heart Association
https://read.qxmd.com/read/34050802/myocardial-stress-perfusion-in-asymptomatic-patients-the-silent-ischemia-makes-the-loudest-sound
#26
EDITORIAL
Jonathan R Weir-McCall, Stephen P Hoole
No abstract text is available yet for this article.
August 2021: European Radiology
https://read.qxmd.com/read/34016259/international-prospective-registry-of-acute-coronary-syndromes-in-patients-with-covid-19
#27
MULTICENTER STUDY
Thomas A Kite, Peter F Ludman, Chris P Gale, Jianhua Wu, Adriano Caixeta, Jacques Mansourati, Manel Sabate, Pilar Jimenez-Quevedo, Luciano Candilio, Parham Sadeghipour, Angel M Iniesta, Stephen P Hoole, Nick Palmer, Albert Ariza-Solé, Alim Namitokov, Hector H Escutia-Cuevas, Flavien Vincent, Otilia Tica, Mzee Ngunga, Imad Meray, Andrew Morrow, Md Minhaj Arefin, Steven Lindsay, Ghada Kazamel, Vinoda Sharma, Aly Saad, Gianfranco Sinagra, Federico Ariel Sanchez, Marek Roik, Stefano Savonitto, Marija Vavlukis, Shankar Sangaraju, Iqbal S Malik, Sharon Kean, Nick Curzen, Colin Berry, Gregg W Stone, Bernard J Gersh, Anthony H Gershlick
BACKGROUND: Published data suggest worse outcomes in acute coronary syndrome (ACS) patients and concurrent coronavirus disease 2019 (COVID-19) infection. Mechanisms remain unclear. OBJECTIVES: The purpose of this study was to report the demographics, angiographic findings, and in-hospital outcomes of COVID-19 ACS patients and compare these with pre-COVID-19 cohorts. METHODS: From March 1, 2020 to July 31, 2020, data from 55 international centers were entered into a prospective, COVID-ACS Registry...
May 25, 2021: Journal of the American College of Cardiology
https://read.qxmd.com/read/34006503/risks-and-benefits-of-percutaneous-coronary-intervention-in-spontaneous-coronary-artery-dissection
#28
JOURNAL ARTICLE
Deevia Kotecha, Marcos Garcia-Guimaraes, Diluka Premawardhana, Dario Pellegrini, Clare Oliver-Williams, Vasiliki Bountziouka, Alice Wood, Nalin Natarajan, Robert Jackson, Nathan Chan, Jan Ziaullah, Roby D Rakhit, Stephen P Hoole, Tom W Johnson, Jacek Kadziela, Peter Ludman, Nilesh J Samani, Angela H E M Maas, Robert-Jan van Geuns, Fernando Alfonso, David Adlam
OBJECTIVE: To investigate percutaneous coronary intervention (PCI) practice in an international cohort of patients with spontaneous coronary artery dissection (SCAD). To explore factors associated with complications and study angiographic and longer term outcomes. METHODS: SCAD patients (n=215, 94% female) who underwent PCI from three national cohort studies were investigated and compared with a matched cohort of conservatively managed SCAD patients (n=221). RESULTS: SCAD-PCI patients were high risk at presentation with only 8...
September 2021: Heart
https://read.qxmd.com/read/33942478/outcomes-following-pci-in-cabg-candidates-during-the-covid-19-pandemic-the-prospective-multicentre-uk-revasc-registry
#29
MULTICENTER STUDY
Thomas A Kite, Andrew Ladwiniec, Colum G Owens, Alexander Chase, Aadil Shaukat, Abdul M Mozid, Peter O'Kane, Helen Routledge, Divaka Perera, Ajay K Jain, Nick Palmer, Stephen P Hoole, Mohaned Egred, Manas K Sinha, Thomas J Cahill, Luciano Candilio, Brijesh Anantharam, Jonathan Byrne, Simon J Walsh, Margaret McEntegart, Sharon Kean, Laraib Siddique, Charley Budgeon, Nick Curzen, Colin Berry, Peter Ludman, Anthony H Gershlick
OBJECTIVES: To describe outcomes following percutaneous coronary intervention (PCI) in patients who would usually have undergone coronary artery bypass grafting (CABG). BACKGROUND: In the United Kingdom, cardiac surgery for coronary artery disease (CAD) was dramatically reduced during the first wave of the COVID-19 pandemic. Many patients with "surgical disease" instead underwent PCI. METHODS: Between 1 March 2020 and 31 July 2020, 215 patients with recognized "surgical" CAD who underwent PCI were enrolled in the prospective UK-ReVasc Registry (ReVR)...
February 2022: Catheterization and Cardiovascular Interventions
https://read.qxmd.com/read/33932990/glp-1-vasodilatation-in-humans-with-coronary-artery-disease-is-not-adenosine-mediated
#30
JOURNAL ARTICLE
Muhammad Aetesam-Ur-Rahman, Joel P Giblett, Bharat Khialani, Stephen Kyranis, Sophie J Clarke, Tian X Zhao, Denise M Braganza, Sarah C Clarke, Nick E J West, Martin R Bennett, Stephen P Hoole
BACKGROUND: Incretin therapies appear to provide cardioprotection and improve cardiovascular outcomes in patients with diabetes, but the mechanism of this effect remains elusive. We have previously shown that glucagon-like peptide (GLP)-1 is a coronary vasodilator and we sought to investigate if this is an adenosine-mediated effect. METHODS: We recruited 41 patients having percutaneous coronary intervention (PCI) for stable angina and allocated them into four groups administering a specific study-related infusion following successful PCI: GLP-1 infusion (Group G) (n = 10); Placebo, normal saline infusion (Group P) (n = 11); GLP-1 + Theophylline infusion (Group GT) (n = 10); and Theophylline infusion (Group T) (n = 10)...
May 1, 2021: BMC Cardiovascular Disorders
https://read.qxmd.com/read/33830637/glucagon-like-peptide-1-receptor-agonists-improve-biomarkers-of-inflammation-and-oxidative-stress-a-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#31
JOURNAL ARTICLE
Jonathan J H Bray, Harri Foster-Davies, Ahmed Salem, Amy L Hoole, Daniel R Obaid, Julian P J Halcox, Jeffrey W Stephens
AIM: To conduct a meta-analysis and systematic review to examine the effects of glucagon-like peptide-1 receptor agonists (GLP-1RAs) on clinical biomarkers of inflammation and oxidative stress in patients with type 2 diabetes. METHODS: Medline, Embase and the Cochrane Library were searched for randomised controlled trials (RCTs) that examined changes with GLP-1RAs in a priori selected biomarkers of inflammation: C-reactive protein (CRP), adiponectin, tumour necrosis factor-alpha (TNFα), plasminogen activator inhibitor-1, interleukin-6, leptin; and of oxidative stress: malondialdehyde (MDA); 8-iso-prostaglandin F2α; and 8-hydroxy-2'-deoxyguanosine (8-OHdG)...
August 2021: Diabetes, Obesity & Metabolism
https://read.qxmd.com/read/33783498/rituximab-in-patients-with-acute-st-elevation-myocardial-infarction-an-experimental-medicine-safety-study
#32
JOURNAL ARTICLE
Tian X Zhao, Muhammad Aetesam-Ur-Rahman, Andrew P Sage, Saji Victor, Rincy Kurian, Sarah Fielding, Hafid Ait-Oufella, Yi-Da Chiu, Christoph J Binder, Mikel Mckie, Stephen P Hoole, Ziad Mallat
AIMS: In pre-clinical models of acute myocardial infarction (MI), mature B cells mobilize inflammatory monocytes into the heart, leading to increased infarct size and deterioration of cardiac function, whilst anti-CD20 antibody-mediated depletion of B cells limits myocardial injury and improves cardiac function. Rituximab is a monoclonal anti-CD20 antibody targeted against human B cells. However, its use in cardiovascular disease is untested and is currently contraindicated. Therefore, we assessed the safety, feasibility, and pharmacodynamic effect of rituximab given to patients with acute ST-elevation MI (STEMI)...
February 21, 2022: Cardiovascular Research
https://read.qxmd.com/read/33664801/balloon-pulmonary-angioplasty-state-of-the-art
#33
REVIEW
John G Coghlan, Alexander Mk Rothman, Stephen P Hoole
Balloon pulmonary angioplasty (BPA) is a novel technique for the treatment of chronic thromboembolic pulmonary hypertension. While cardiologists need no introduction to the concept of balloon angioplasty, BPA has its own particular challenges. This article aims to provide the reader with an overview of BPA, starting with an introduction to chronic thromboembolic disease (CTED), the standard management of chronic thromboembolic pulmonary hypertension (CTEPH), technical challenges faced when performing BPA and the evidence base supporting its use...
April 2020: Interventional Cardiology
https://read.qxmd.com/read/33442588/covid-19-patient-with-coronary-thrombosis-supported-with-ecmo-and-impella-5-0-ventricular-assist-device-a-case-report
#34
JOURNAL ARTICLE
Kamen Valchanov, Unni Krishnan, Stephen P Hoole, Will R Davies, Stephen Pettit, Nicola Jones, Jas Parmar, Pedro Catarino, Mohamed Osman, Marius Berman
BACKGROUND: COVID-19 can present with cardiovascular complications. CASE SUMMARY: We present a case report of a 43-year-old previously fit patient who suffered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection with thrombosis of the coronary arteries causing acute myocardial infarction. These were treated with coronary stenting during which the patient suffered cardiac arrest. He was supported with automated chest compressions followed by peripheral veno-arterial extracorporeal membrane oxygenation (VA ECMO)...
December 2020: European Heart Journal. Case Reports
https://read.qxmd.com/read/33399285/insertion-technique-for-the-impella-5-0-heart-pump-in-the-covid-19-era
#35
Marius Berman, Eyal Nachum, Mohammed Osman, John Hogan, Stephen Hoole, Pedro Catarino
We describe the insertion of the Impella 5.0, a peripherally placed mechanical cardiovascular microaxial pump, in a patient with ischemic left ventricular dysfunction. The Impella is a 7 Fr device capable of achieving a flow of 4.0-5.0 L/min; its use necessitates an open arterial cut-down. A subclavicular incision is used to access the right or left axillary artery. A 10-mm tube graft is anastomosed to the artery through which the Impella 5.0 is inserted. The device traverses the tube graft and is advanced via the aorta, across the aortic valve, to its final position (inflow toward the ventricular apex and outflow above the aorta)...
December 23, 2020: Multimedia Manual of Cardiothoracic Surgery: MMCTS
https://read.qxmd.com/read/33004619/non-hyperaemic-pressure-ratios-to-guide-percutaneous-coronary-intervention
#36
REVIEW
Michael Michail, Udit Thakur, Ojas Mehta, John M Ramzy, Andrea Comella, Abdul Rahman Ihdayhid, James D Cameron, Stephen J Nicholls, Stephen P Hoole, Adam J Brown
The use of fractional flow reserve (FFR) in guiding revascularisation improves patient outcomes and has been well-established in clinical guidelines. Despite this, the uptake of FFR has been limited, likely attributable to the perceived increase in procedural time and use of hyperaemic agents that can cause patient discomfort. This has led to the development of instantaneous wave-free ratio (iFR), an alternative non-hyperaemic pressure ratio (NHPR). Since its inception, the use of iFR has been supported by an increasing body of evidence and is now guideline recommended...
October 2020: Open Heart
https://read.qxmd.com/read/32942043/rationale-and-design-of-the-medical-research-council-s-precision-medicine-with-zibotentan-in-microvascular-angina-prize-trial
#37
JOURNAL ARTICLE
Andrew J Morrow, Thomas J Ford, Kenneth Mangion, Tushar Kotecha, Roby Rakhit, Gavin Galasko, Stephen Hoole, Anthony Davenport, Rajesh Kharbanda, Vanessa M Ferreira, Mayooran Shanmuganathan, Amedeo Chiribiri, Divaka Perera, Haseeb Rahman, Jayanth R Arnold, John P Greenwood, Michael Fisher, Dirk Husmeier, Nicholas A Hill, Xiaoyu Luo, Nicola Williams, Laura Miller, Jill Dempster, Peter W Macfarlane, Paul Welsh, Naveed Sattar, Andrew Whittaker, Alex Mc Connachie, Sandosh Padmanabhan, Colin Berry
Microvascular angina is caused by cardiac small vessel disease, and dysregulation of the endothelin system is implicated. The minor G allele of the non-coding single nucleotide polymorphism (SNP) rs9349379 enhances expression of the endothelin 1 gene in human vascular cells, increasing circulating concentrations of ET-1. The prevalence of this allele is higher in patients with ischemic heart disease. Zibotentan is a potent, selective inhibitor of the ETA receptor. We have identified zibotentan as a potential disease-modifying therapy for patients with microvascular angina...
July 17, 2020: American Heart Journal
https://read.qxmd.com/read/32839116/lack-of-strategic-funding-and-long-term-job-security-threaten-to-have-profound-effects-on-cardiovascular-researcher-retention-in-australia
#38
JOURNAL ARTICLE
Rachel E Climie, Jason H Y Wu, Anna C Calkin, Niamh Chapman, Sally C Inglis, Katrina M Mirabito Colafella, Dean S Picone, Joanne T M Tan, Emma Thomas, Helena M Viola, Steven G Wise, Andrew J Murphy, Mark R Nelson, Stephen J Nicholls, Livia C Hool, Kerry Doyle, Gemma A Figtree, Francine Z Marques
BACKGROUND: Cardiovascular disease is the leading cause of death in Australia. Investment in research solutions has been demonstrated to yield health and a 9.8-fold return economic benefit. The sector, however, is severely challenged with success rates of traditional peer-reviewed funding in decline. Here, we aimed to understand the perceived challenges faced by the cardiovascular workforce in Australia prior to the COVID-19 pandemic. METHODS: We used an online survey distributed across Australian cardiovascular societies/councils, universities and research institutes over a period of 6 months during 2019, with 548 completed responses...
August 21, 2020: Heart, Lung & Circulation
https://read.qxmd.com/read/32757258/coronary-artery-dissection-following-radiofrequency-ablation-for-atrial-fibrillation-case-report-and-review-of-the-literature
#39
S Ashwin Reddy, Bharat V Khialani, Stephen Kyranis, Stephen P Hoole
Coronary artery injury following catheter ablation for cardiac arrhythmias is very rare. We present a case of left circumflex (LCx) coronary artery dissection causing inferoposterior ST-elevation myocardial infarction following radiofrequency (RF) ablation for atrial fibrillation (AF) in a 39-year-old male with no cardiovascular risk factors. This was confirmed on coronary angiography and intracoronary vascular ultrasound (IVUS). The likely etiology is thermal injury during RF ablation for AF, due to the close proximity of the left atrial appendage and left pulmonary veins to the LCx...
August 5, 2020: Catheterization and Cardiovascular Interventions
https://read.qxmd.com/read/32522821/recent-advances-in-percutaneous-coronary-intervention
#40
REVIEW
Stephen P Hoole, Paul Bambrough
Percutaneous coronary intervention (PCI) continues to advance at pace with an ever-broadening indication. In this article we will review the recent technological advances in PCI that have enabled more complex coronary disease to be treated. The choice of revascularisation strategy must take into account the evidence-just because we can treat by PCI does not necessarily mean we should. When PCI is indicated, a safe, precision PCI approach guided by physiology, imaging and optimal lesion preparation should be the goal to obtain complete revascularisation and a durable long-term result...
June 10, 2020: Heart
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