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Quantitative measurement

Dongyang Wang, Jianjun Zhang, Zengjun Li, Jianjun Han, Yongsheng Gao, Ming Chen, Yanqing Li
Fibroblast growth factor 19 (FGF19) promotes tumor growth in various types of cancer, but its function has not been investigated in the context of colorectal adenoma. Here, we report that FGF19 expression was greater in colorectal adenoma than in normal tissues, as measured by an enzyme-linked immunosorbent assay, quantitative reverse-transcription PCR and immunohistochemistry. FGF19 expression was also elevated in a subset of human colon cancer cell lines. Moreover, FGF receptor 4 (FGFR4), the cognate receptor for FGF19, was upregulated in colorectal adenoma tissues...
December 5, 2018: Digestive Diseases
Junpu Li, Shaoshen Li, Lunhui Huang, Yaqiong Cui, Tiantian She, Ying Bian, Huiqiang Li
BACKGROUND: An increase in allergen-specific IgG4 (sIgG4 ), which serves as a blocking antibody, is associated with acquisition of immune tolerance after immunotherapy. In this study, we developed a rapid, sensitive, and homogeneous immunoassay based on the light-initiated chemiluminescent assay (LICA) technology for quantifying allergen sIgG4 in serum samples. METHODS: Allergen sIgG4 was measured in vitro by incubating the sample with biotinylated allergens and chemiluminescent beads coated with anti-human IgG4 antibody, followed by the addition of streptavidin-coated sensitizer beads...
December 2, 2018: Clinica Chimica Acta; International Journal of Clinical Chemistry
Fabio Baselice, Giampaolo Ferraioli, Vito Pascazio, Antonietta Sorriso
Data coming from any acquisition system, such as Magnetic Resonance Imaging ones, are affected by noise. Although modern high field scanners can reach high Signal to Noise Ratios, in some circumstances, for example in case of very weak signals due to a specific acquisition sequence, noise becomes a critical issue that has to be properly handled. In last years methods based on the so called Non Local Mean have proven to be very effective in denoising tasks. The idea of these filters is to find similar patches across the image and to jointly exploit them to obtain the restored image...
December 2, 2018: Magnetic Resonance Imaging
Elizabeth Anne Kinsella, Kirsten Smith, Saara Bhanji, Rachelle Shepley, Andreja Modor, Andrew Bertrim
BACKGROUND: Investigations into the use of mindfulness with allied health and social care students, many of whom ultimately work in rehabilitation settings, is in the nascent stages and no systematic mapping of the literature has occurred. The purpose of this scoping review was to identify, summarise, and describe the current state of knowledge on mindfulness in allied health and social care professional education. METHODS: Arksey and O'Malley's scoping review methodology was adopted...
December 5, 2018: Disability and Rehabilitation
Roya Ostovar, Martin Hartrumpf, Ralf-Uwe Kuehnel, Filip Schroeter, Magdalena Laux, Michael Erb, Thomas Claus, Johannes Maximilian Albes
OBJECTIVES: The invention of new surgical procedures requires testing at different stages including animal models. To facilitate this process, we have developed a computer-controlled extracorporeal circulation system for testing of an explanted porcine heart simulating a variety of physiological parameters. Mitral valve function can be assessed before and after induced valve insufficiency and after valve repair. Accordingly, techniques and instruments can be modified at early stages of prototype development...
December 4, 2018: Interactive Cardiovascular and Thoracic Surgery
Márcia Marques Dos Santos Felix, Maria Beatriz Guimarães Ferreira, Lucas Felix de Oliveira, Elizabeth Barichello, Patricia da Silva Pires, Maria Helena Barbosa
OBJECTIVE: to evaluate the effect of relaxation therapy with guided imagery on state anxiety and cortisol in the immediate preoperative period in patients submitted to bariatric surgery by videolaparoscopy. METHOD: a randomized, triple-blind clinical trial in a large teaching hospital in the interior of Minas Gerais. Twenty-four patients who would undergo video-laparoscopic bariatric surgery were randomly allocated in two groups, namely 12 in the control group and 12 in the experimental group...
November 29, 2018: Revista Latino-americana de Enfermagem
Ricardo Roberto de Souza Fonseca, Ana Cláudia Braga Amoras Alves, Thalita de Almeida Amanajás, Brenna Magdalena Lima Nogueira, Tatiany Oliveira de Alencar Menezes, Leonardo Quintão Siravenha, Danilo Leôncio Aguiar Pereira, Luiz Fernando Almeida Machado, Luciana Campêlo da Silva Gilet, Silvio Augusto Fernandes de Menezes
INTRODUCTION: The influence of cytomegalovirus (CMV) on the progression of chronic periodontitis in HIV patients is poorly investigated. METHODS: ELISA was used for anti-CMV antibody IgG titer measurements and real-time polymerase chain reaction for qualitative and quantitative CMV detection. Data on the CD4 + T lymphocyte count and plasma HIV viral load were obtained from patient records. RESULTS: CMV DNA was detected in samples of subgingival biofilm in only three individuals, two of them with chronic periodontitis (4%) and one with gingivitis (3...
November 2018: Revista da Sociedade Brasileira de Medicina Tropical
Adriana Elisa Carcereri de Oliveira, Adrielle Barbosa Machado, Edson Duque Dos Santos, Érika Bicalho de Almeida
OBJECTIVE: To measure the response time of health professionals before sound alarm activation and the implications for patient safety. METHOD: This is a quantitative and observational research conducted in an Adult Intensive Care Unit of a teaching hospital. Three researchers conducted non-participant observations for seven hours. Data collection occurred simultaneously in 20 beds during the morning shift. When listening the alarm activation, the researchers turned on the stopwatches and recorded the motive, the response time and the professional conduct...
November 2018: Revista Brasileira de Enfermagem
Delano Gurgel Silveira, Márcio Alencar Barreira, Luiz Gonzaga de Moura Junior, Charles Jean Gomes de Mesquita, Hermano Alexandre Lima Rocha, Gleydson Cesar de Oliveira Borges
PURPOSE: To discuss the use of models of hepatic retraction by laparoscopy, to present a new Hepatic Retractor (HR) and to evaluate its practicality, efficacy and safety in Esophageal Hiatus Exposure (EHE). METHODS: Experimental cross - sectional study with a quantitative character. It was carried out in the Laboratory of Health Training of Christus University Center. The sample consisted of 12 livers of adult pigs weighing between 30 and 45 kg. A circular-shaped HR, 5 cm diameter and deformable materials was developed with a polypropylene cloth, metallic guide wire, epidural needle plastic guide and nylon string...
November 2018: Acta Cirúrgica Brasileira
Jan Ketil Arnulf, Kai Rune Larsen, Øyvind Lund Martinsen
Research on sensemaking in organisations and on linguistic relativity suggests that speakers of the same language may use this language in different ways to construct social realities at work. We apply a semantic theory of survey response (STSR) to explore such differences in quantitative survey research. Using text analysis algorithms, we have studied how language from three media domains-the business press, PR Newswire and general newspapers-has differential explanatory value for analysing survey responses in leadership research...
2018: PloS One
John R Humm, Narayan Yoganandan, Klaus G Driesslein, Frank A Pintar
OBJECTIVES: Analyses of recent automotive accident data indicate an increased risk of injury for small female occupants compared to males in similar accidents. Females have been shown to be more susceptible to spinal injuries than males. To protect this more vulnerable population, advanced anthropomorphic test devices (ATDs) and computer human body models are being developed and require biofidelity curves for validation. The aim of this study is to generate female-specific 3D kinematic corridors in near- and far-side oblique frontal impacts for the head, spine, and pelvis...
December 5, 2018: Traffic Injury Prevention
Jacquie Baker, Kurt Kimpinski
BACKGROUND: In evaluating autonomic dysfunction, the autonomic reflex screen (ARS) is an established set of standardized tests to evaluate the presence and severity of autonomic dysfunction. Our laboratory previously reported normative data on 121 healthy individuals; however, the sample size in older individuals was reduced compared to other age groups. Therefore, the objective of the current study was to provide updated normative values representative of young, middle aged and older individuals from Southwestern Ontario...
December 5, 2018: Canadian Journal of Physiology and Pharmacology
Andras Bodi, Patrick Hemberger
The threshold photoelectron spectrum and low-energy dissociative photoionization processes of formamide and acetamide were studied using photoelectron photoion coincidence spectroscopy and vacuum ultraviolet synchrotron radiation. Ab initio calculations and Franck-Condon simulations helped us assign the main vibrational progressions in the spectra and enabled the first conclusive assignment of the first electronically excited states. The adiabatic ionization energies to the X and A states of formamide (10.236 ± 0...
December 5, 2018: Journal of Physical Chemistry. A
Jeong-Mo Choi, Rohit V Pappu
Experimentally derived, amino acid specific backbone dihedral angle distributions are invaluable for modeling data-driven conformational equilibria of proteins and for enabling quantitative assessments of the accuracies of molecular mechanics forcefields. The protein coil library that is extracted from analysis of high-resolution structures of proteins, has served as a useful proxy for quantifying intrinsic and context-dependent conformational distributions of amino acids. However, data that go into coil libraries will have hidden biases, and ad hoc procedures must be used to remove these biases...
December 5, 2018: Journal of Chemical Theory and Computation
Na Fang, Niannian Zhong, Tingxuan Gu, Yahui Wang, Xiangqian Guo, Shaoping Ji
BACKGROUND: Adoptive cell therapy (ACT) based on chimeric antigen receptors (CARs) expressed on the surface of T cells shows a remarkable clinical outcome, particularly for B-cell malignancies. However, toxicity and side effects of CD19-redirected CAR T cells have been observed concurrently in most cases due to cytokine release and tumor cell lysis. Therefore, strictly controlling the amount of valid T cells re-transfused to patients seems to be an important step in reducing toxicity and side effects of CAR T cells...
December 5, 2018: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
Davoud Pourmarzi, Lisa Hall, Julie Hepworth, Andrew Smirnov, Tony Rahman, Gerrard FitzGerald
Several community-based models for treating Hepatitis C Virus (HCV) infection have been implemented to improve treatment accessibility and health outcomes. However, there is a lack of knowledge regarding how well these models achieve the desired goals. We conducted a mixed-method systematic review of quantitative and qualitative evidence about clinical effectiveness, cost effectiveness and acceptability of community-based HCV treatment models. Seventeen databases were researched for published and unpublished studies...
December 5, 2018: Journal of Viral Hepatitis
Fabrício Guimarães Gonçalves, Suraj D Serai, Giulio Zuccoli
Synthetic magnetic resonance imaging is a novel imaging technique that allows generating multiple contrast-weighted images based on relaxivity measurements of tissue properties in a single acquisition using a multiecho, multidelay saturation recovery spin-echo sequence. The synthetic images can be generated postacquisition from the parametric tissue maps, which can be beneficial to reduce scan time and improve patient throughput. Based on relaxometry maps, synthetic magnetic resonance imaging can also perform brain tissue segmentation and myelin quantification without additional scan time...
December 2018: Topics in Magnetic Resonance Imaging: TMRI
Seher Unver, Semra Eyi, Zeynep Kizilcik Ozkan
Pain during negative pressure wound therapy (NPWT) has been reported in the literature. PURPOSE: The study was conducted to describe patients' pain experience, pain-coping skills, and the effect of NPWT-related pain on daily life activities following abdominal surgery. METHOD: Using a descriptive, qualitative design, semi-structured face-to-face interviews were conducted between April 3, 2016 and December 26, 2016, in the surgical ward of a university hospital in Edirne, Turkey...
December 2018: Ostomy/wound Management
Feng-Lei Yang, Xin Chen, Wen-Hao Wu, Jing-Hang Zhang, Xiang-Mei Zhao, Yan-Hui Shi, Fei Shen
As a derivative of 2-picolylamine, which contains rich protons favouring hydrogen bond formation to assemble a variety of valuable spin crossover (SCO) compounds, 8-aminoquinoline (aqin) will be a good candidate for constructing new mononuclear bistable state compounds. With the guidance of this view, two solvated compounds [Fe(aqin)3](BPh4)2·2(CH3CN) (1·2CH3CN) and [Fe(aqin)3](BPh4)2·1.5(CH3COCH3) (2·1.5CH3COCH3) were synthesized. The structural characterization and magnetic studies demonstrate that this strategy has been successful...
December 5, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Heather Taffet Gold, Raj J Karia, Alissa Link, Rachel Lebwohl, Joseph D Zuckerman, Thomas J Errico, James D Slover, Aaron J Buckland, Devin M Mann, Michael N Cantor
We integrated and optimized patient-reported outcome measures into the electronic health record to provide quantitative, objective data regarding patients' health status, which is important for patient care, payer contracts, and research. With a multidisciplinary team from information technology, clinical informatics, population health, and physician champions, we used formal human-computer interaction techniques and user-centered design to integrate several technology platforms and computerized adaptive testing for the National Institutes of Health Patient-Reported Outcomes Measurement Information System...
December 5, 2018: Health Informatics Journal
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