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https://www.readbyqxmd.com/read/30342275/pmma-double-modified-organoclay-nanocomposites-as-fillers-for-denture-base-materials-with-improved-mechanical-properties
#1
Fateme Shakeri, Azizollah Nodehi, Mohammad Atai
The aim of this study was to investigate the effect of double-modified organoclay on mechanical properties of polymethylmethacrylate (PMMA) denture base resins. An organoclay was further modified via a silanization process using 3-trimethoxysilylpropyl methacrylate (MPS) as a reactive silane coupling agent. X-ray diffraction patterns (XRD), thermogravimetric analysis (TGA), and Fourier-transform infrared spectroscopy (FTIR) confirmed the presence of MPS in the resulting double-modified nanoclay structure. Surface tension of the original and double-modified nanoclays, were determined using contact angle measurements...
September 26, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/30342268/exogenous-tetranectin-protects-against-mpp-induced-neurotoxicity-by-inhibiting-apoptosis-and-autophagy-through-p70s6k1
#2
Qiang Xie, Meng Liu, Yu-Feng Yan, Xiao Shen, Er-Song Wang
BACKGROUD: Tetranectin is a secreted homotrimeric protein belonging to the C-type lectin family. Our previous studies found that tetranectin was not only related to, but also played a protective role in Parkinson's disease. In this study, we aim to illustrate the molecular mechanism of the secreted tetranectin. METHODS: We used exogenous tetranectinto investigate the function and molecular mechanism of secreted tetranectin in a 1-methyl-4-phenylpyridine (MPP+ )-induced SH-SY5Y cell model...
October 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/30342214/prognostic-nomogram-for-patients-with-hostile-neck-anatomy-after-endovascular-abdominal-aortic-aneurysm-repair
#3
Min Zhou, Yonggang Wang, Yong Ding, Liang Cai, Changpo Lin, Zhenyu Shi, Weiguo Fu
OBJECTIVE: Since the introduction of endovascular aortic aneurysm repair (EVAR), the morphology of aneurysm neck has a great impact on prognosis of patients underwent elective abdominal aortic aneurysm (AAA) repair. In this study, we aimed to analyze the morphologic features and prognosis after EVAR for patients with hostile neck anatomy, and tried to create a novel prognostic nomogram in predicting EVAR-related adverse events. METHODS: We retrospectively reviewed 812 patients with infra-renal AAA underwent elective EVAR procedures between January 2010 and December 2015 at our single center, and identified patients with hostile neck...
October 17, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/30342153/properties-of-natural-rubber-reinforced-with-cellulose-nanofibers-based-on-fiber-diameter-distribution-as-estimated-by-differential-centrifugal-sedimentation
#4
Akio Kumagai, Naoko Tajima, Shinichiro Iwamoto, Takahiro Morimoto, Asahiro Nagatani, Toshiya Okazaki, Takashi Endo
Cellulose nanofibers (CNFs) with different degrees of fibrillation are prepared by the mechanical fibrillation of kraft pulp using wet disk milling, and dispersions of the prepared CNFs were subjected to differential centrifugal sedimentation (DCS) in order to estimate the diameter distributions of the CNFs. The low-fibrillated CNFs (fiber diameter (d): >10 μm) had a weak reinforcing effect on natural rubber (NR), while the medium-fibrillated CNFs (d: 0.1-10 μm) dramatically improve the initial modulus and decrease the elongation at break...
October 17, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/30341647/comparative-analysis-of-high-field-mri-and-histology-for-ex-vivo-whole-organ-imaging-assessment-of-placental-functional-morphology-in-a-murine-model
#5
Chressen Catharina Remus, Emilia Solano, Thomas Ernst, Rene Thieme, Kurt Hecher, Gerhard Adam, Petra Arck
OBJECTIVES: The purpose of our study was to evaluate MRI as a tool to examine placental morphology in a murine model in comparison to classical histology techniques. METHODS: Assessment of placental samples (n = 24) from C57Bl/6 J mice was performed using MR imaging and histomorphological analyses. To optimize image contrast for MRI, a protocol for gadolinium-mediated enhancement of placental tissue was established. To test method sensitivity, placental zone assessment with MRI and histology was applied to a model of prenatal stress exposure known to affect placental morphology (n = 10)...
October 19, 2018: Magma
https://www.readbyqxmd.com/read/30341511/role-of-tgf-%C3%AE-1-signaling-in-heart-valve-calcification-induced-by-abnormal-mechanical-stimulation-in-a-tissue-engineering-model
#6
Xing-Jian Hu, Wen-Cong-Hui Wu, Nian-Guo Dong, Jia-Wei Shi, Jun-Wei Liu, Si Chen, Chen Deng, Feng Shi
A tissue engineering model of heart valve calcification induced in a bioreactor was established to evaluate the calcification induced by abnormal mechanical stimulation and explore the underlying molecular mechanisms. Polyethylene glycol (PEG)-modified decellularized porcine aortic leaflets seeded with human valve interstitial cells (huVICs) were mounted on a Ti-Ni alloy frame to fabricate two-leaflet and threeleaflet tissue engineered valves. The two-leaflet model valves were exposed to abnormal pulsatile flow stimulation with null (group A), low (1000 mL/min, group B), medium (2000 mL/min, group C), and high velocity (3000 mL/min, group D) for 14 days...
October 2018: Current medical science
https://www.readbyqxmd.com/read/30341510/upregulation-of-mir-126-delays-the-senescence-of-human-glomerular-mesangial-cells-induced-by-high-glucose-via-telomere-p53-p21-rb-signaling-pathway
#7
Dong-Wei Cao, Chun-Ming Jiang, Cheng Wan, Miao Zhang, Qing-Yan Zhang, Min Zhao, Bo Yang, Da-Long Zhu, Xiao Han
Diabetic kidney disease (DKD) is a microvascular complication of type 2 diabetes. The study of DKD mechanisms is the most important target for the prevention of DKD. Renal senescence is one of the important pathogeneses for DKD, but the mechanism of renal and cellular senescence is unclear. Decreased expression of circulating miR-126 is associated with the development of DKD and may be a promising blood-based biomarker for DKD. This study is to probe the effect and mechanism of miR-126 on the aging of human glomerular mesangial cells (HGMCs) induced by high glucose...
October 2018: Current medical science
https://www.readbyqxmd.com/read/30340887/ventricular-torsion-in-young-patients-with-single-ventricle-anatomy
#8
Michael Grattan, Luc Mertens, Lars Grosse-Wortmann, Mark K Friedberg, Barbara Cifra, Andreea Dragulescu
BACKGROUND: In normal left ventricles, clockwise basal rotation and counterclockwise apical rotation result in systolic torsion. Torsion is important for contractile efficiency and may be especially important in single-ventricle (SV) physiology. However, little is known about torsion in patients with SVs. The aim of this study was to measure torsion in SVs and to determine its relationship with other measures of ventricular function. The hypothesis was that torsion would be decreased in all SVs, most significantly in single right ventricles, and that it would correlate with other measures of ventricular function...
October 17, 2018: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/30340463/evaluation-of-valve-function-in-antireflux-biliary-metal-stents
#9
Chang-Il Kwon, Jong Pil Moon, Ho Yun, Seok Jeong, Dong Hee Koh, Woo Jung Lee, Kwang Hyun Ko, Dae Hwan Kang
BACKGROUND: To overcome duodenobiliary reflux induced by biliary stents, antireflux valve (ARV) biliary stents have been developed and showed improvement in stent patency. However, negative study results have also been reported because stent patency may be decreased by the malfunction of ARV itself. Given such mixed results, the true efficacy of ARV remains unknown and the mechanism of its dysfunction needs to be clearly elucidated. The aim of this study was to investigate the exact mechanism of ARV dysfunction using in vitro phantom models...
October 19, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/30340413/molecular-disorder-of-bicalutamide-amorphous-solid-dispersions-obtained-by-solvent-methods
#10
Joanna Szafraniec, Agata Antosik, Justyna Knapik-Kowalczuk, Karolina Gawlak, Mateusz Kurek, Jakub Szlęk, Witold Jamróz, Marian Paluch, Renata Jachowicz
The effect of solvent removal techniques on phase transition, physical stability and dissolution of bicalutamide from solid dispersions containing polyvinylpyrrolidone (PVP) as a carrier was investigated. A spray dryer and a rotavapor were applied to obtain binary systems containing either 50% or 66% of the drug. Applied techniques led to the formation of amorphous solid dispersions as confirmed by X-ray powder diffractometry and differential scanning calorimetry. Moreover, solid⁻solid transition from polymorphic form I to form II was observed for bicalutamide spray dried without a carrier...
October 18, 2018: Pharmaceutics
https://www.readbyqxmd.com/read/30340317/study-on-the-tribological-performance-of-copper-based-powder-metallurgical-friction-materials-with-cu-coated-or-uncoated-graphite-particles-as-lubricants
#11
Xin Zhang, Yongzhen Zhang, Sanming Du, Zhenghai Yang, Tiantian He, Zhen Li
The tribological performance of copper-based powder metallurgical material is much influenced by the interfacial bonding between the components and matrix. By adding Cu-coated or uncoated graphite particles as a lubricant, two types of copper-based powder metallurgical materials were prepared via spark plasma sintering (SPS). The hardness, relative density, and thermal conductivity of the two specimens were firstly measured. Using an inertial braking test bench and temperature measuring instrument, the average friction coefficients, instantaneous friction coefficients, and friction temperatures of the two specimens were tested under different test conditions, and the wear rates were calculated accordingly...
October 18, 2018: Materials
https://www.readbyqxmd.com/read/30339688/inertial-properties-of-the-german-shepherd-dog
#12
O Yvette Jones, Silvia U Raschke, Philip E Riches
One of the most popular dog breeds deployed by both the police and military has been the German Shepherd yet little is known about the morphology or body segment parameters of this breed. Such measures are essential for developing biomechanical models which, in turn, may guide clinicians in developing surgical interventions, injury treatment and prevention procedures. This paper provides a complete set of body segment parameters and inertial properties for the German Shepherd. Morphometric measures and 3-dimensional inertial properties, including mass, centre of mass, moment of inertia and volume, were measured from 17 segments from 6 German Shepherd police service dog cadavers...
2018: PloS One
https://www.readbyqxmd.com/read/30339496/genetic-deletion-of-the-alamandine-receptor-mrgd-leads-to-dilated-cardiomyopathy-in-mice
#13
Aline Cristina Oliveira, Marcos Barrouin Melo, Daisy Motta-Santos, Antonio Ab Peluso, Fernando Souza-Neto, Rafaela F da Silva, Jonathas Fq Almeida, Giovanni Canta, Adelina M Reis, Gleisy Goncalves, Gabriela G Cerri, Danielle Coutinho, Itamar Couto Guedes de Jesus, Silvia Guatimosim, Natalia D Linhares, Natalia Alenina, Michael Bader, Maria José Campagnole-Santos, Robson A Souza Santos
We have recently described a new peptide of the renin angiotensin system, alamandine, a derivative of angiotensin-(1-7). The Mas-related G-protein coupled receptor member D (MrgD) was identified as its receptor. Although similar cardioprotective effects of alamandine to those of Ang-(1-7) have been described, the significance of this peptide in heart function is still elusive. We aimed to evaluate the functional role of the alamandine receptor, MrgD, in the heart, using MrgD-deficient mice. MrgD was localized in cardiomyocytes by immunofluorescence using confocal microscopy...
October 19, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/30339389/shape-controlled-nanoparticles-in-pore-confined-space
#14
Johannes Knossalla, Paul Paciok, Daniel Göhl, Daniel Jalalpoor, Enrico Pizzutilo, Andrea M Mingers, Marc Heggen, Rafal Dunin-Borkowski, Karl J J Mayrhofer, Ferdi Schüth, Marc Ledendecker
Increasing the catalyst's stability and activity are one of the main quests in catalysis. Tailoring crystal surfaces to a specific reaction has demonstrated to be a very effective way in increasing the catalyst's specific activity. Shape-controlled nano-particles with specific crystal facets are usually grown kinetically and are highly susceptible to morphological changes during the reaction due to agglomeration, metal dissolution, or Ostwald ripening. A strong interaction of the catalytic material to the support is thus crucial for successful stabilization...
October 19, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/30339327/automated-detection-of-cancer-cells-in-effusion-specimens-by-dna-karyometry
#15
Alfred H Böcking, David Friedrich, Dietrich Meyer-Ebrecht, Chenyan Zhu, Anna Feider, Stefan Biesterfeld
BACKGROUND: The average sensitivity of conventional cytology for the identification of cancer cells in effusion specimens is only approximately 58%. DNA image cytometry (DNA-ICM), which exploits the DNA content of morphologically suspicious nuclei measured on digital images, has a sensitivity of up to 91% for the detection of cancer cells. However, when performed manually, to our knowledge to date, an expert needs approximately 60 minutes for the analysis of a single slide. METHODS: In the current study, the authors present a novel method of supervised machine learning for the automated identification of morphologically suspicious mesothelial and epithelial nuclei in Feulgen-stained effusion specimens...
October 19, 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/30339263/progression-to-surgery-for-patients-with-idiopathic-epiretinal-membranes-and-good-vision
#16
Xuejing Chen, Kendra A Klein, Chirag P Shah, Jeffery S Heier
BACKROUND AND OBJECTIVE: Patients with idiopathic epiretinal membranes (ERMs) and visual acuity of 20/40 or better are often monitored until vision or associated symptoms worsen to affect everyday living. This study looks at the rate of progression to surgery and the characteristics associated with progression. PATIENTS AND METHODS: This study was a retrospective, consecutive case series of patients with newly diagnosed idiopathic ERMs who were referred to the Retina Service at the Ophthalmic Consultants of Boston between January 2009 and May 2015 with 20/40 or better visual acuity...
October 15, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/30338761/effect-of-metabolic-syndrome-on-neural-plasticity-and-morphology-of-the-hippocampus-correlations-of-neurological-deficits-with-physiological-status-of-the-rat
#17
Zdenka Gasparova, Pavol Janega, Peter Weismann, Hisham El Falougy, Barbara Tyukos Kaprinay, Boris Liptak, Dominika Michalikova, Ruzena Sotnikova
Fat-rich diet (FRD) triggers health complications like hypertension, dyslipidemia, hyperglycemia, insulin resistance and non-alcoholic fatty liver disease, known as the risk factors of metabolic syndrome (MetS), which may result in neurological deficits. The impact of MetS on neuronal functions and brain morphology are poorly understood. We induced MetS-like conditions by exposing hypertriacylglycerolemic (HTG) rats to FRD for eight weeks with the aim to study possible neurological dysfunctions. HTG-FRD rats were compared to HTG rats and Wistar rats on standard diet...
October 19, 2018: General Physiology and Biophysics
https://www.readbyqxmd.com/read/30338513/increased-maternal-abdominal-subcutaneous-fat-thickness-and-body-mass-index-are-associated-with-increased-cesarean-delivery-a-prospective-cohort-study
#18
Victoria Eley, Renuka Sekar, Adrian Chin, Timothy Donovan, Amy Krepska, Mitchell Lawrence, Sheridan Bell, Shaun McGrath, Alexander Robinson, Lachlan Webb, Louise Marquart
INTRODUCTION: Early pregnancy body mass index (BMI) is known to predict adverse pregnancy outcomes but does not account for body fat distribution. This study aimed to prospectively determine if maternal abdominal subcutaneous fat thickness (SCFT) measured by ultrasound at the fetal morphology scan is a better predictor of mode of delivery and other pregnancy outcomes, than BMI. MATERIAL AND METHODS: This was a prospective cohort study of women delivering singleton neonates at a tertiary public hospital...
October 18, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/30338296/early-onset-parkinson-disease-caused-by-a-mutation-in-chchd2-and-mitochondrial-dysfunction
#19
Richard G Lee, Maryam Sedghi, Mehri Salari, Anne-Marie J Shearwood, Maike Stentenbach, Ariana Kariminejad, Hayley Goullee, Oliver Rackham, Nigel G Laing, Homa Tajsharghi, Aleksandra Filipovska
Objective: Our goal was to identify the gene(s) associated with an early-onset form of Parkinson disease (PD) and the molecular defects associated with this mutation. Methods: We combined whole-exome sequencing and functional genomics to identify the genes associated with early-onset PD. We used fluorescence microscopy, cell, and mitochondrial biology measurements to identify the molecular defects resulting from the identified mutation. Results: Here, we report an association of a homozygous variant in CHCHD2 , encoding coiled-coil-helix-coiled-coil-helix domain containing protein 2, a mitochondrial protein of unknown function, with an early-onset form of PD in a 26-year-old Caucasian woman...
October 2018: Neurology. Genetics
https://www.readbyqxmd.com/read/30338151/high-speed-ultrahigh-resolution-distal-scanning-oct-endoscopy-at-800-nm-for-in-vivo-imaging-of-colon-tumorigenesis-on-murine-models
#20
Jessica Mavadia-Shukla, Payam Fathi, Wenxuan Liang, Shaoguang Wu, Cynthia Sears, Xingde Li
We present the first, most compact, ultrahigh-resolution, high-speed, distal scanning optical coherence tomography (OCT) endoscope operating at 800 nm. Achieving high speed imaging while maintaining an ultrahigh axial resolution is one of the most significant challenges with endoscopic OCT at 800 nm. Maintaining an ultrahigh axial resolution requires preservation of the broad spectral bandwidth of the light source throughout the OCT system. To overcome this critical limitation we implemented a distal scanning endoscope with diffractive optics to minimize loss in spectral throughput...
August 1, 2018: Biomedical Optics Express
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