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Ovidiu Burta, Claudia Iacobescu, Radu Bogdan Mateescu, Tudor Nicolaie, Nicoleta Tiuca, Corina Silvia Pop
Background: Bloating is a common symptom reported by around 16% to 31% of the general population. Functional bloating is diagnosed in patients with recurrent symptoms of bloating who do not meet the diagnostic criteria of irritable bowel syndrome or other functional gastrointestinal disorders. Methods: This double-blind, multicentre, randomised study compared the safety and efficacy of APT036 (xyloglucan plus tyndallized Lactobacillus reuteri and Bifidobacterium brevis ; Aprotecol® ) and simethicone in treating functional bloating in adults...
2018: Translational Gastroenterology and Hepatology
Theertham Pradyumna Rao, Giuseppina Quartarone
Digestive health plays key role in our active daily life; but maintaining proper bowel movements, i.e., being free from constipation, diarrhea, irritable bowel syndrome, inflammatory bowel disease, flatulence, bloating, and abdominal pain, is complex. Dietary fibers often are recommended to maintain proper digestive health, but none seems to provide a single comprehensive solution for overall maintanance of proper digestive health. Guar fiber, however, has emerged as a credible candidate for just such a solution...
August 23, 2018: Nutrition
Zhiqin Wong, Chu-Zhen Mok, Hazreen Abdul Majid, Sanjiv Mahadeva
Background: The efficacy and acceptance of a low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet in Asian adults with irritable bowel syndrome (IBS) remain uncertain. We aimed to describe our early experience in a single center with a dedicated gastroenterology dietetic service. Methods: Consecutive patients with IBS referred to our dedicated Dietetic Gastroenterology Clinic between February 2016 and May 2016 were screened...
October 2018: JGH open: an open access journal of gastroenterology and hepatology
Aamer Imdad, Maribeth R Nicholson, Emily E Tanner-Smith, Joseph P Zackular, Oscar G Gomez-Duarte, Dawn B Beaulieu, Sari Acra
BACKGROUND: Inflammatory bowel disease (IBD) is a chronic, relapsing disease of the gastrointestinal tract that is thought to be associated with a complex interplay between microbes and the immune system, leading to an abnormal inflammatory response in genetically susceptible individuals. Dysbiosis, characterized by the alteration of the composition of the resident commensal bacteria in a host compared to healthy individuals, is thought to play a major role in the pathogenesis of ulcerative colitis (UC) and Crohn's disease (CD), two subtypes of IBD...
November 13, 2018: Cochrane Database of Systematic Reviews
Bonnie J Bristow, Merrylee McGuffin, Ewa Szumacher, Margaret Fitch, Lisa Di Prospero, Laura D'Alimonte
PURPOSE: Evidence has shown that the prostate moves depending on filling of the rectum and, to a lesser extent, the bladder; many radiation therapy departments have adopted standardized bladder filling/rectal emptying protocols for radiotherapy treatment. Daily treatments may be delayed until appropriate volumes are attained; the resultant psychological impact of these delays on patients is unknown. The purpose of this study was to determine levels of anxiety, depression, distress, and bother related to bowel preparation for prostate cancer patients undergoing radiation therapy treatment...
March 2018: Journal of Medical Imaging and Radiation Sciences
Seyed Morteza Mousavi Naeini, Alireza Khalaj, Ali Abbaszadeh-Kasbi, Seyed Rouhollah Miri
Background  There are several surgical approaches to treat obesity not cured with medical approaches. Each method has its advantages and complications. In here, we have conducted a study to evaluate complications of biliointestinal bypass surgery (BIBP). Methods  A prospective study was conducted in a private hospital from 2002 to 2016. Those patients, not previously operated for morbid obesity, were eligible. Mean follow-up period was 89 months ( ± 54 months; range: 73-108 months). Main outcome measures were weight, BMI (body mass index), concentrations of blood lipids and glucose, liver transaminases, and obesity-related comorbidities and complications...
October 2018: Surgery Journal
Irene Koulinska, Katherine Riester, Spyros Chalkias, Michael R Edwards
PURPOSE: Flushing and gastrointestinal (GI) events are commonly associated with the use of delayed-release dimethyl fumarate (DMF) treatment for relapsing multiple sclerosis. METHODS: PREVENT (A Multicenter, Double-Blind, Placebo-Controlled Study of Pepto-Bismol [Bismuth Subsalicylate] on Gastrointestinal Tolerability in Healthy Volunteers Receiving Oral TECFIDERA [Dimethyl Fumarate] Delayed-Release Capsules Twice Daily) is a double-blind, placebo-controlled, 8-week study that evaluated the effect of bismuth subsalicylate on DMF-related GI events...
November 14, 2018: Clinical Therapeutics
Nittaya Chansiw, Kamonnaree Chotinuntakool, Somdet Srichairatanakool
BACKGROUND: Polygonum odoratum is an indigenous vegetable that has been used as a favoring agent and also used as a Thai traditional medicine to treat flatulence. OBJECTIVE: To analyze active ingredients, total phenolic and total flavonoid contents, anti-inflammatory and antioxidant activities from leaf and stem extracts of P. odoratum. METHODS: Leaves and stems were dried and extracted by using methanol, dichloromethane and water for obtaining methanolic leaf extract (MLE), methanolic stem extract (MTE), dichloromethane leaf extract (DLE), dichloromethane stem extract (DTE), water leaf extract (WLE) and water stem extract (WTE)...
November 9, 2018: Anti-inflammatory & Anti-allergy Agents in Medicinal Chemistry
Filippo Fassio, Maria Sole Facioni, Fabio Guagnini
Milk is a fundamental component of the diet of every mammal; nevertheless, not every individual can tolerate this kind of food, especially in adulthood. However, lactose intolerance has only been recognized in the last 50 years, and currently, lactose intolerance is defined as a clinical syndrome characterized by pain, abdominal distention, flatulence, and diarrhoea that occur after lactose consumption. Lactose is currently a common disaccharide in human nutrition, both in breastfed infants and in adults, but its digestion requires a specialized enzyme called lactase...
November 1, 2018: Nutrients
Bingyong Mao, Hongyu Tang, Jiayu Gu, Dongyao Li, Shumao Cui, Jianxin Zhao, Hao Zhang, Wei Chen
Raffinose has become a major focus of research interest and recent studies have shown that besides beneficial bifidobacteria and lactobacilli, Escherichia coli, Enterococcus faecium and Streptococcus pneumoniae can also utilize raffinose and raffinose might lead to flatulence in some hosts. Therefore, it is required to find out the raffinose-metabolizing bacteria in the gut and the bacteria responsible for the flatulence. The BLASTP search results showed that the homologous proteins of glycosidases related to raffinose utilization are widely distributed in 196 of the 528 gut bacterial strains...
November 14, 2018: Food & Function
Claire O'Gorman, Jim Stack, Alan O'Ceilleachair, Suzanne Denieffe, Martina Gooney, Martina McKnight, Linda Sharp
BACKGROUND: Colorectal cancer is a significant issue internationally, with over 1.3 million people diagnosed annually. Survival rates are increasing as treatments improve, although physical symptoms can persist despite eradication of the tumour. In order to optimize survivorship care, further research is warranted in relation to symptom burden. Therefore, the objectives of this study are to (i) investigate frequency of physical symptoms in colorectal cancer survivors (ii) identify which symptoms occur together (iii) examine the associations between demographic and clinical variables, and symptoms...
October 22, 2018: BMC Cancer
Ozlem Akalpler, Hulya Okumus
Objective: To determine the effect of gum chewing on bowel function postoperatively in women after cesarean delivery under spinal anesthesia. Methods: This semi-experimental study was conducted at Near East University Hospital Obstetrics and Gynecology Clinic in Turkish Republic of Northern Cyprus with 45 women in both the +experimental and control groups, between October 2016 and June 2017. The women in the experimental group chewed gum two hours after surgery until gut sounds were heard and nutrition was given orally...
September 2018: Pakistan Journal of Medical Sciences Quarterly
Eva Z Reininghaus, Lisa-Christin Wetzlmair, Frederike T Fellendorf, Martina Platzer, Robert Queissner, Armin Birner, Ren Pilz, Carlo Hamm, Alexander Maget, Alexandra Rieger, Antonia Prettenhofer, Walter Wurm, Sabrina Mörkl, Nina Dalkner
The importance of the microbiome for psychological well-being has gained rising interest in the last decade. A strategy to examine the role of the microbiome in different diseases is the intake of supplements that modulate the gut microbiome. Despite promising results in animal studies, research in humans is sparse to date and especially in individuals with psychiatric disorders almost missing. The current report of the ProbioBIP-one pilot study aims at describing general effects of the intake of the probiotic OMNi-BiOTiC Stress repair® on psychological parameters as well as gastrointestinal symptoms and general compliance in a cohort of euthymic individuals with bipolar disorder (BD), receiving daily probiotic treatment over a time period of 3 months...
October 19, 2018: Neuropsychobiology
Honggang Wang, Bota Cui, Qianqian Li, Xiao Ding, Pan Li, Ting Zhang, Xiaozhong Yang, Guozhong Ji, Faming Zhang
INTRODUCTION: Fecal microbiota transplantation (FMT) has been used as a potential treatment option for Crohn's disease (CD). However, there is still lack of safety and efficacy evidence based on large samples of CD undergoing FMT. This study aimed to evaluate the risk factors of adverse event (AE) in the long term and the efficacy of FMT in the short term for patients with CD. METHODS: FMT via mid-gut for mild to severe CD in a single center trial (NCT01793831) was performed from October 2012 to December 2016...
November 2018: Advances in Therapy
Lei Jin, Lin Deng, Wei Wu, Zhenyi Wang, Wanjin Shao, Jianhua Liu
BACKGROUND: To evaluate the effect of probiotic supplementation on functional constipation in children. METHODS: We performed electronic searches in PubMed, Embase, and Cochrane Library without language restriction to identify relevant studies from the time of inception of these databases to March 2018. The relative risk or weighted mean difference was calculated to evaluate the treatment effect of probiotics using random-effects model. RESULTS: We included 4 trials reporting data on 382 children with functional constipation...
September 2018: Medicine (Baltimore)
Bo Zhang, Kelei Zhu, Pingping Hu, Feng Xu, Liang Zhu, Jiande D Z Chen
BACKGROUND: Postsurgical gastrointestinal disturbance is clinically characterized by the delayed passage of flatus and stool, delayed resumption of oral feeding, dyspepsia symptoms, and postsurgical pain. This study was designed 1) to evaluate the effects of needleless transcutaneous neuromodulation (TN) on postoperative recovery; 2) to investigate mechanisms of the TN involving autonomic functions in postoperative patients after removal of the gallbladder. METHODS: Sixty patients scheduled for laparoscopic cholecystectomy (LC) were randomized to TN (n = 30) and sham-TN (n = 30)...
October 1, 2018: Neuromodulation: Journal of the International Neuromodulation Society
Amir Abbasnezhad, Reza Amani, Amin Hasanvand, Esmaeil Yousefi Rad, Meysam Alipour, Somayeh Saboori, Razieh Choghakhori
OBJECTIVE: A high prevalence of vitamin D deficiency (VDD) in gastrointestinal (GI) disorders and the role of vitamin D in the function of the gut have been shown previously. Therefore, we aimed to evaluated the VDD and the possible association of the GI symptoms severity and quality of life (QoL) score with the serum levels of vitamin D in irritable bowel syndrome (IBS). METHODS: A total of 90 patients with IBS based on Rome III criteria enrolled in the study from the tertiary referral university hospital...
September 25, 2018: Journal of the American College of Nutrition
Xueran Geng, Jing Fan, Lijing Xu, Hexiang Wang, Tzi Bun Ng
A novel acidic α-galactosidase (EC designated as Leucopaxillus tricolor α-galactosidase (LTG) has been purified to homogeneity from the fruiting bodies of L. tricolor to 855-fold with a specific activity of 956 U mg-1 by the application of chromatography and gel filtration. The molecular mass of LTG was estimated to be 60 kDa as determined by both SDS-PAGE and by gel filtration. The purified enzyme was identified by LC-MS/MS and four inner amino acid sequences were obtained. When 4-nitrophenyl α-D-glucopyranoside (pNPGal) was used as substrate, the optimal pH and optimal temperature of LTG were pH 5...
September 5, 2018: Journal of Basic Microbiology
Jelena Vulevic, George Tzortzis, Aleksandra Juric, Glenn R Gibson
BACKGROUND: Prebiotics exert beneficial effects upon gastrointestinal (GI) environment, but this is not always accompanied with a positive effect on GI symptoms. B-GOS® is a prebiotic with high selectivity toward bifidobacteria and a variety of other beneficial effects in humans. Here, we investigated its effect on GI symptoms in adults who suffer with bloating, abdominal pain, and flatulence. METHODS: In a double-blind, placebo-controlled, crossover study, 83 subjects from the general population who presented with GI symptoms during screening period and had a predicted probability of functional bowel disorder of more than 75% were randomized to receive either a placebo or the B-GOS® treatment (2...
November 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
Alicia N Webb Milum, Craig E Griffin, Kacie S Blessing
BACKGROUND: English bulldogs (EBDs) are considered to commonly show signs of pododermatitis and gastrointestinal (GI) disease. HYPOTHESIS/OBJECTIVES: To describe a population of presumed healthy EBDs: (i) evaluate dogs according to published criteria for health, (ii) describe paw lesions, if present, (iii) report pruritic behaviours and GI signs and compare to normal values, (iv) report pedal cytological findings, and (v) determine correlation between lesions, cytological results and pruritic behaviours...
October 2018: Veterinary Dermatology
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