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Functional pain

Kasia K Marciszewski, Noemi Meylakh, Flavia Di Pietro, Emily P Mills, Vaughan G Macefield, Paul M Macey, Luke A Henderson
The neural mechanism responsible for migraine remains unclear. Whilst an external trigger has been proposed to initiate a migraine, it has also been proposed that changes in brainstem function are critical for migraine headache initiation and maintenance. Although the idea of altered brainstem function has some indirect support, no study has directly measured brainstem pain modulation circuitry function in migraineurs particularly immediately prior to a migraine. In male and female humans, we performed functional magnetic resonance imaging in 31 control and 31 migraineurs at various times in their migraine cycle...
October 19, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Daniel López-López, Ricardo Becerro-de-Bengoa-Vallejo, Marta Elena Losa-Iglesias, Patricia Palomo-López, David Rodríguez-Sanz, Juan Manuel Brandariz-Pereira, César Calvo-Lobo
OBJECTIVE: Foot problems (FP) may be considered to be a prevalent conditions in people but there is limited evidence of their effect on the quality of life (QoL) related to foot health in men and women. The aim of this study was to assess the impact of FPs on both overall foot health and QoL, stratified by gender. DESIGN: A cross sectional study. SETTING: Clinic of Podiatric Medicine and Surgery at University of A Coruña in the city of Ferrol (Spain)...
October 18, 2018: BMJ Open
Ana Kowark, Christian Adam, Jörg Ahrens, Malek Bajbouj, Cornelius Bollheimer, Matthias Borowski, Richard Dodel, Michael Dolch, Thomas Hachenberg, Dietrich Henzler, Frank Hildebrand, Ralf-Dieter Hilgers, Andreas Hoeft, Susanne Isfort, Peter Kienbaum, Mathias Knobe, Pascal Knuefermann, Peter Kranke, Rita Laufenberg-Feldmann, Carla Nau, Mark D Neuman, Cynthia Olotu, Christopher Rex, Rolf Rossaint, Robert D Sanders, Rene Schmidt, Frank Schneider, Hartmut Siebert, Max Skorning, Claudia Spies, Oliver Vicent, Frank Wappler, Dieter Christian Wirtz, Maria Wittmann, Kai Zacharowski, Alexander Zarbock, Mark Coburn
INTRODUCTION: Hip fracture surgery is associated with high in-hospital and 30-day mortality rates and serious adverse patient outcomes. Evidence from randomised controlled trials regarding effectiveness of spinal versus general anaesthesia on patient-centred outcomes after hip fracture surgery is sparse. METHODS AND ANALYSIS: The iHOPE study is a pragmatic national, multicentre, randomised controlled, open-label clinical trial with a two-arm parallel group design...
October 18, 2018: BMJ Open
Jun Wang, Yin Wang, Hui Zhang, Ming Lu, Weilu Gao, Li Yin, Zongsheng Yin
INTRODUCTION: Osteoarthritis is a common degenerative joint disease that eventually leads to disability and poor quality of life. The main symptoms are joint pain and mobility disorders. If the patient has severe pain or other analgesics are contraindicated, opioids may be a viable treatment option. To evaluate and compare the efficacy and safety of opioids in the treatment of knee or hip osteoarthritis, we will integrate direct and indirect evidence using a Bayesian network meta-analysis to establish hierarchies of these drugs...
October 18, 2018: BMJ Open
Franziska Ostner, Theresa Hergt, Sandrina Klein, Dorian Patzkéwitsch, Sven Reese, Andreas Brühschwein, Andrea Meyer-Lindenberg, Benjamin Schade, Brigitte Böhm, Rudolf Eisenreich, Anja Rostalski, Kay-Uwe Götz, Michael Erhard, Mathias Ritzmann, Susanne Zöls
OBJECTIVE: The aim of the first part of the present study was to specify risk factors for the development of adventitious bursae on the limbs of weaning and finishing pigs. MATERIAL AND METHODS: In total, 192 pigs were examined weekly, recording the following parameters: general condition, number, size and localization of adventitious bursae on the limbs and sternum, gait and claws. RESULTS: Adventitious bursae can occur at 13 positions on the limbs or sternum...
October 2018: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
Kohei Koga, Yu Matsuzaki, Keisuke Migita, Shuji Shimoyama, Fumihiro Eto, Tatsuki Nakagawa, Taichi Matsumoto, Kazuki Terada, Kenichi Mishima, Hidemasa Furue, Kenji Honda
Cholinergic systems modulate synaptic transmission across the neuraxis and play an important role in higher brain function including cognition, arousal and nociception. The anterior cingulate cortex (ACC) is a fundamental brain region for nociception and chronic pain, and receives cholinergic projections mainly from basal forebrain. Recently, we found that the activation of muscarinic M1 receptors in the ACC produced antinociceptive behavior in response to mechanical stimulation. However, it has not been tested whether stimulating muscarinic receptors in the ACC can reduce mechanical hypersensitivity in animal models of chronic pain...
October 16, 2018: Brain Research
Katarzyna Ochalek, Hugo Partsch, Tomasz Gradalski, Zbigniew Szygula
BACKGROUND: In a previous randomized controlled trial it has been demonstrated that arm compression sleeves worn immediately after breast cancer surgery, including axillary lymph node removal in addition to physical therapy are able to reduce the occurrence of early postoperative swelling and of arm lymphedema up to 1 year and to improve quality of life. The aim of the present investigation was to check the further development of the arm swelling in patients using compression sleeves or not, and to compare the quality of life in women treated due to breast cancer 2 years after surgery...
October 19, 2018: Lymphatic Research and Biology
Laura M Paulin, Benjamin M Smith, Abby Koch, MeiLan Han, Eric A Hoffman, Carlos Martinez, Chinedu Ejike, Paul D Blanc, Jennifer Rous, R Graham Barr, Stephen P Peters, Robert Paine, Cheryl Pirozzi, Christopher B Cooper, Mark T Dransfield, Alejandro P Comellas, Richard E Kanner, M Brad Drummond, Nirupama Putcha, Nadia N Hansel
RATIONALE: Quantitative computed tomography (CT) imaging can aid in COPD phenotyping. Few studies have identified whether occupational exposures are associated with distinct CT imaging characteristics. OBJECTIVE: To examine the association between occupational exposures and CT-measured patterns of disease in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS). METHODS: Participants underwent whole-lung multidetector helical CT at full inspiration and expiration...
October 19, 2018: Annals of the American Thoracic Society
Tamar Jacob, Jillian Bracha
Background and Purpose: Axillary web syndrome (AWS) and seroma are common and function-limiting side effects after breast cancer treatments. Studies of AWS and seroma are rare, and there are no guidelines for physical therapy in these cases. Case Description: After left breast lumpectomy due to invasive ductal carcinoma, a 65-year-old female patient underwent intraoperative radiation therapy and whole breast radiation. Seven months later, during treatment for breast swelling, AWS and breast seroma were identified by a physical therapist certified in lymphedema treatment...
October 18, 2018: Physical Therapy
Elisabetta Bellia, Luca Boggione, Mara Terzini, Carlo Manzella, Guilio Menicucci
PURPOSE: This preliminary case series report sought to evaluate the efficacy of an immediate loading protocol for mandibular overdentures retained by two mini-implants with the outcome measures patient satisfaction, masticatory cycles, and masticatory efficiency at 1 year. MATERIALS AND METHODS: A convenience sample of 11 patients was recruited, and the clinical protocol consisted of immediately loading two mini-implants (10 mm long and 2.4 mm or 2.9 mm in diameter) via a mandibular overdenture connection with Locator attachments...
July 30, 2018: International Journal of Prosthodontics
F Fang, J Wang, Y-F Wang, Y-D Peng
OBJECTIVE: Microangiopathy is a major cause in diabetic polyneuropathy (DPN). This review examines evidence from both human and animal studies to elucidate the important microvascular factors in DPN. MATERIALS AND METHODS: This is a literature review of articles published on PubMed in English. RESULTS: There is an abundance of evidence linking endoneurial microvascular abnormalities to peripheral nerve dysfunction and pathology in patients with diabetes...
October 2018: European Review for Medical and Pharmacological Sciences
David N Bernstein, Michael R Anderson, Judith F Baumhauer, Irvin Oh, A Samuel Flemister, John P Ketz, Benedict F DiGiovanni
BACKGROUND: Achilles tendinopathy is a common clinical disorder. Utilizing the Patient-Reported Outcomes Measurement Information System, we aim to determine clinical response to nonoperative achilles tendinopathy rehabilitative care of insertional achilles tendinopathy compared to non-insertional achilles tendinopathy. METHODS: Prospective Patient-Reported Outcomes Measurement Information System Physical Function, Pain Interference, and Depression scores were collected for patients with achilles tendinopathy at presentation and following a standard course of nonoperative care...
October 19, 2018: Foot & Ankle Specialist
Jun Inamo, Yuko Kaneko, Komei Sakata, Tsutomu Takeuchi
OBJECTIVE: To investigate the impact of subclinical synovitis detected by ultrasonography (US) on the ankles and feet of patients with rheumatoid arthritis. METHODS: We retrospectively reviewed the data of patients (n = 59) who underwent US. RESULTS: The functional ability and quality of life (QoL) of patients in the subclinical group were impaired. While the physician visual analog scale (VAS) scores significantly decreased in the subclinical group, patient and pain VAS scores significantly decreased only in patients without synovitis...
October 18, 2018: International Journal of Rheumatic Diseases
József Szalma, Balázs Soós, Károly Krajczár, Edina Lempel
The present report describes a case where sealer extrusion (Sealapex) occurred during root canal obturation of a left lower second premolar tooth, and the patient experienced sudden pain and followed by complete anaesthesia of the lower lip. After 3 weeks of conservative therapy and an unaltered anaesthesia period, piezosurgical removal of the extruded sealer and root-end resection was performed despite the direct contact with the mental neurovascular bundle. At suture removal, 1 week after surgery, there was no improvement in sensation...
October 18, 2018: Australian Endodontic Journal: the Journal of the Australian Society of Endodontology Inc
Dekun Yin, Yonglin Chen, Rongxiang Lu, Bingbing Fan, Shunxing Zhu, Xingguo Xu, Zhongling Xu
Neuropathic pain is a severe debilitating state caused by injury or dysfunction of somatosensory nervous system, and the clinical treatment is still challenging. Translocation associated membrane protein 1 (TRAM1), an adapter protein, participates in a variety of transduction pathways and mediates the biological functions such as cell proliferation, activation, and differentiation. However, whether TRAM1 is involved in the pathogenesis of neuropathic pain is still unclear. In our study, we reported the role of TRAM1 in the maintenance of neuropathic pain induced by chronic constriction injury (CCI) on rats...
October 18, 2018: Journal of Molecular Neuroscience: MN
Natalie Clohesy, Anthony Schneiders
Background: The current utilisation of patient reported outcome measures (PROMs) for low back pain (LBP) within the Australian Chiropractic profession is unknown. The aims of this study were to determine the current utilisation of LBP PROMs amongst Chiropractors in Australia and to identify the potential barriers and facilitators of using PROMs for LBP in Chiropractic practice. Methods: A cross sectional online survey was distributed to Chiropractors in Australia who were members of the Chiropractic Association of Australia (CAA) and Chiropractic Australia (CA) between June-August 2016...
2018: Chiropractic & Manual Therapies
Douaa M Mosalem, Shothour M Alghunaim, Diaa K Shehab, Ayyoub B Baqer, Aziz K Alfeeli, Mohieldin M Ahmed
BACKGROUND: To our knowledge, the importance of US findings, pain (brief pain inventory (BPI)) and disability in osteoarthritic knee (OA) pain patients remain uncertain. AIM: The objectives are to evaluate the correlation of US findings, pain (brief pain inventory (BPI)) and disability in OA pain patients. MATERIALS AND METHODS: Eighty - three patients with OA knee were divided into two groups. The first group was OA as symptomatic knee group and the second group was an asymptomatic control group...
September 25, 2018: Open Access Macedonian Journal of Medical Sciences
Onur Koyuncu, Sedat Hakimoglu, Mustafa Ugur, Cagla Akkurt, Selim Turhanoglu, Daniel Sessler, Alparslan Turan
OBJECTIVE: Acetaminophen is effective for acute surgical pain, but whether it reduces persistent incision pain remains unknown. We tested the primary hypothesis that patients given perioperative acetaminophen have less incisional pain three months after surgery. Our secondary hypotheses were that patients randomized to acetaminophen have less postoperative pain and analgesic consumption, and better functional recovery at three months. METHODS: 140 patients having abdominal hysterectomy were randomly assigned to: 1)intravenous acetaminophen (4 g/day for 72 postoperative hours); or, 2) saline placebo...
2018: Annali Italiani di Chirurgia
Bruno P Chumpitazi
Diet plays a significant role for children with functional abdominal pain disorders. A large majority of these children identify at least 1 food that exacerbates their symptoms. Malabsorbed carbohydrates may have both direct and microbiome-mediated physiologic effects. There are several factors associated with carbohydrate symptom generation, including (1) the amount ingested, (2) ingestion with a meal, (3) small intestinal enzymatic activity, (4) consuming the carbohydrate with microorganisms capable of breaking down the carbohydrate, (5) the gut microbiome, and (6) host factors...
December 2018: Gastroenterology Clinics of North America
Nikolai Siebert, Sascha Troschke-Meurer, Madlen Marx, Maxi Zumpe, Karoline Ehlert, Juliet Gray, Alberto Garaventa, Carla Manzitti, Shifra Ash, Thomas Klingebiel, James Beck, Victoria Castel, Dominique Valteau-Couanet, Hans Loibner, Ruth Ladenstein, Holger N Lode
GD₂-directed immunotherapies improve survival of high-risk neuroblastoma (NB) patients (pts). Treatment with chimeric anti-GD₂ antibodies (Ab), such as ch14.18, can induce development of human anti-chimeric Ab (HACA). Here, we report HACA effects on ch14.18/CHO pharmacokinetics, pharmacodynamics and pain intensity in pts treated by long-term infusion (LTI) of ch14.18/CHO combined with IL-2. 124 pts received up to 5 cycles of ch14.18/CHO 10 days (d) infusion (10 mg/m²/d; d8⁻18) combined with s.c. IL-2 (6 × 10⁶ IU/m²/d; d1⁻5, d8⁻12)...
October 17, 2018: Cancers
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