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Functional pain

Bettina Böttcher, Elke R Gizewski, Christian Siedentopf, Ruth Steiger, Michael Verius, David Riedl, Anja Ischebeck, Julia Schmid, Ludwig Wildt, Sigrid Elsenbruch
BACKGROUND: Chronic pelvic pain, in particular dysmenorrhea, is a significant yet unresolved healthcare problem in gynecology. As interoceptive sensitivity and underlying neural mechanisms remain incompletely understood, this functional magnetic resonance imaging (fMRI) study assessed behavioral and neural responses to visceral stimuli in primary dysmenorrhea (PMD). METHODS: Women with PMD (N=19) without psychological comorbidity and healthy women (N=20) were compared with respect to visceral sensory and pain thresholds, and to neural responses to individually-calibrated mildly-painful and painful rectal distensions implemented during scanning...
August 11, 2018: European Journal of Pain: EJP
J Carles, A Pichler, H Korunkova, A Tomova, M Ghosn, F El Karak, J Makdessi, I Koroleva, G Barnes, D Bury, A Özatilgan, S Hitier, J Katolicka
OBJECTIVES: To obtain routine clinical practice data on cabazitaxel usage patterns for patients with metastatic castration-resistant prostate cancer (mCRPC) and to describe physician-assessed cabazitaxel effectiveness, health-related quality of life (HRQL) and safety. PATIENTS AND METHODS: CAPRISTANA was an international, observational cohort study examining cabazitaxel use for the treatment of patients with mCRPC. Effectiveness was assessed by overall survival (OS), progression-free survival (PFS), time to treatment failure (TTF) and disease control rate...
August 11, 2018: BJU International
Gustaf Magaard, Per Wester, Richard Levi, Peter Lindvall, Emma Gustafsson, Arzhang Nazemroaya Sedeh, Malin Lönnqvist, Stina Berggren, Kristin Nyman, Xiaolei Hu
BACKGROUND: Unmet rehabilitation needs are common among stroke survivors. We aimed to evaluate whether a comprehensive graphic "Rehab-Compass," a novel combination of structured patient-reported outcome measures, was feasible and useful in facilitating a capture of patients' rehabilitation needs in clinical practice. METHODS: A new graphic overview of broad unmet rehabilitation needs covers deficits in functioning, daily activity, participation, and quality of life...
August 7, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
Jaime Ruiz-Tovar, Maria Blanca, Alejandro Garcia, Juan Gonzalez, Sonsoles Gutierrez, Amalia Paniagua, Maria Jose Prieto, Luisa Ramallo, Lucia Llanos, Manuel Duran
BACKGROUND: The term "Immunonutrition" (IMN) describes the enteral administration of certain substrates with a theoretical immunomodulating function. From all the elements conforming these IMN formulas, Omega-3 fatty acids (O3FA) are hypothesized to be the most important component for immunomodulation, with increased anti-inflammatory and antioxidant effect. PATIENTS AND METHODS: A prospective randomized clinical trial of all the patients undergoing laparoscopic Roux-en-Y gastric bypass was performed...
July 29, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
Stamati Morias, Loredana Gabriela Marcu, Michala Short, Eileen Giles, Eva Bezak
Stereotactic ablative radiation therapy for lung cancer is an advanced technique where tumours are ablated with hypofractionated radiation doses, with a high degree of accuracy. The aim of this paper is to review the available literature and to discuss the SABR-induced toxicities for lung malignancies as a function of radiation delivery technique. A Medline search was conducted to identify the appropriate literature to fulfil the aim of this review and data from all applicable papers were collated and analysed...
September 2018: Critical Reviews in Oncology/hematology
Joy K Adewusi, Marios Hadjivassiliou, Ana Vinagre-Aragón, Karen Ruth O'Connor, Aijaz Khan, Richard Adam Grünewald, Panagiotis Zis
BACKGROUND AND PURPOSE: Pain is a frequent and debilitating non-motor symptom of Idiopathic Parkinson's Disease (IPD). The present study investigated the prevalence of pain and specifically peripheral neuropathic pain (PNP) in IPD, and ascertained any impact of PNP on quality of life (QoL). METHODS: Patients with IPD and age- and gender-matched controls were screened for overall pain using the King's Parkinson's Pain Scale (KPPS). PNP was assessed using the Michigan Neuropathy Screening Instrument (MNSI)...
September 15, 2018: Journal of the Neurological Sciences
Elyse Thakur, Ana Recober, Carolyn Turvey, Lilian N Dindo
OBJECTIVE: To evaluate effects of an online, hour-long migraine education and management education program on health outcomes in people with migraine experiencing significant depressive symptoms. METHODS: Eligible individuals in the community with comorbid migraine and depressive symptoms (n = 95) participated in the 12-week study. Participants completed self-report questionnaires examining general functioning, headache-specific disability, migraine frequency, pain, and depressive symptoms, before, and at 2, 6, and 12 weeks following the migraine education and management program...
September 2018: Journal of Psychosomatic Research
Annina Seiler, Kyle W Murdock, Christopher P Fagundes
BACKGROUND: Fatigue is a common symptom in stressed individuals. Bereavement is a major life event that has been associated with impaired mental health. Little research has investigated the prevalence of fatigue and its inflammatory correlates in bereaved individuals. OBJECTIVES: To assess fatigue prevalence and its relationship with mental health outcomes and markers of inflammation, as indexed by C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-α) in bereaved individuals...
September 2018: Journal of Psychosomatic Research
Francis Creed, Barbara Tomenson, Carolyn Chew-Graham, Gary Macfarlane, John McBeth
OBJECTIVE: To assess whether two or more functional somatic symptom complexes (SSCs) showed stronger association with psychosocial correlates than single or no SSC after adjustment for depression/anxiety and general medical disorders. METHODS: In a population-based sample we identified, by standardised questionnaire, participants with chronic widespread pain, chronic fatigue and irritable bowel syndrome, excluding those with a medical cause for pain/fatigue. We compared psychosocial variables in three groups: multiple (>1), single or no FSS, adjusting for depression/anxiety and general medical disorders using ordinal logistic regression...
September 2018: Journal of Psychosomatic Research
C Elabd, T E Ichim, K Miller, A Anneling, V Grinstein, V Vargas, F J Silva
BACKGROUND: Mesenchymal stem cells (MSCs) represent an attractive avenue for cellular therapies targeting degenerative diseases. MSC in vitro expansion is required in order to obtain therapeutic numbers during the manufacturing process. It is known that culture conditions impact cellular properties and behavior after in vivo transplantation. In this study, we aimed at evaluating the benefit of hypoxic culturing of human bone marrow derived mesenchymal stem cells on cell fitness and whole genome expression and discussed its implication on cellular therapies targeting orthopedic diseases such as chronic lower back pain...
August 10, 2018: Journal of Translational Medicine
Yixiao Mei, James E Barrett, Huijuan Hu
Calcium release-activated calcium (CRAC) channels are unique among ion channels that are activated in response to depletion of intracellular calcium stores and are highly permeable to Ca2+ compared to other cations. CRAC channels mediate an important calcium signal for a wide variety of cell types and are well studied in the immune system. They have been implicated in a number of disorders such as immunodeficiency, musculosketal disorders and cancer. There is growing evidence showing that CRAC channels are expressed in the nervous system and are involved in pathological conditions including pain...
July 29, 2018: Cell Calcium
Selina C Wriessnegger, Günther Bauernfeind, Eva-Maria Kurz, Philipp Raggam, Gernot R Müller-Putz
The activation of different brain areas during kinaesthetic and visual motor imagery has been extensively studied, whereas little is known about affective motor imagery, i.e. the imagery of pleasant/unpleasant movements. In the present neuroimaging study we investigated cortical activation of kinaesthetic motor imagery (KMI) based on emotional stimulus content by means of functional near infrared spectroscopy (fNIRS). Twenty healthy adult participants were instructed to imagine affective, and neutral motor tasks while multichannel fNIRS was recorded simultaneously...
August 7, 2018: Brain and Cognition
Joshua A Hirsch, Douglas P Beall, M Renée Chambers, Thomas G Andreshak, Allan L Brook, Brian M Bruel, H Gordon Deen, Peter C Gerszten, D Scott Kreiner, Charles A Sansur, Sean M Tutton, Peter van der Meer, Herman J Stoevelaar
BACKGROUND CONTEXT: Vertebral fragility fractures (VFF), mostly due to osteoporosis, are very common and are associated with significant morbidity and mortality. There is a lack of consensus on the appropriate management of patients with or suspected of having a VFF. PURPOSE: This work aimed at developing a comprehensive clinical care pathway (CCP) for VFF. STUDY DESIGN/SETTING: The RAND/UCLA Appropriateness Method (RUAM) was used to develop patient-specific recommendations for the various components of the CCP...
August 7, 2018: Spine Journal: Official Journal of the North American Spine Society
Martin B Brodsky, Matthew J Levy, Erin Jedlanek, Vinciya Pandian, Brendan Blackford, Carrie Price, Gai Cole, Alexander T Hillel, Simon R Best, Lee M Akst
OBJECTIVES: To systematically review the symptoms and types of laryngeal injuries resulting from endotracheal intubation in mechanically ventilated patients in the ICU. DATA SOURCES: PubMed, Embase, CINAHL, and Cochrane Library from database inception to September 2017. STUDY SELECTION: Studies of adult patients who were endotracheally intubated with mechanical ventilation in the ICU and completed postextubation laryngeal examinations with either direct or indirect visualization...
August 9, 2018: Critical Care Medicine
Tânia Costa, Daniela Linhares, Manuel Ribeiro da Silva, Nuno Neves
BACKGROUND: Low back pain associated with lumbar disc herniation is common in the general population, with evident repercussion in quality of life and a significant economic burden. Patients refractory to conservative treatment seek additional treatment and minimally invasive interventions were proposed as valid options. Ozone therapy has been suggested as an alternative due to its potential analgesic and anti-inflammatory effect. OBJECTIVE: This systematic review aims to investigate the effectiveness and safety of ozone therapy for low back pain in patients with lumbar disc herniation...
July 18, 2018: Acta Reumatológica Portuguesa
Benjamin Khechen, Brittany E Haws, Dil V Patel, Mundeep S Bawa, Islam M Elboghdady, Eric H Lamoutte, Sailee S Karmarkar, Kern Singh
STUDY DESIGN: Retrospective cohort. OBJECTIVE: This study aims to determine the validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function (PF) in minimally invasive lumbar discectomy (MIS LD) patients. SUMMARY OF BACKGROUND DATA: PROMIS was designed to allow for assessment of clinical outcomes in fewer questions than previous outcome measures with the goal of reducing non-compliance associated with longer, time-consuming surveys...
August 7, 2018: Spine
Peng Xie, Huan-Li Li, Ling-Ge Wei, Jian-Min Huang
INTRODUCTION: The Technetium-99m diethylene triamine pentaacetic acid (Tc-99m DTPA) renal dynamic scintigraphy is widely used to evaluate the split renal function and continuously demonstrate the whole urinary collecting system. Furthermore, the extrarenal uptake of technetium-99m DTPA can provide useful information for the patients. CASE PRESENTATION: We described a 72-year-old male with a history of flank pain for 8 months and gross hematuria for 3 days. The technetium-99m diethylenetriaminepenta-acetic acid (DTPA) renal dynamic scintigraphy was performed to evaluate the split renal function...
August 2018: Medicine (Baltimore)
Stephen J Pearson, Sarah Stadler, Hylton Menz, Dylan Morrissey, Isabelle Scott, Shannon Munteanu, Peter Malliaras
OBJECTIVES: Isometric muscle contractions are used in the management of patellar tendinopathy to manage pain and improve function. Little is known about whether long- or short-duration contractions are optimal to improve pain. This study examined the immediate and short-term (4 weeks) effects of long- and short-duration isometric contraction on patellar tendon pain, and tendon adaptation. DESIGN: Repeated measures within groups. SETTING: Clinical primary care...
August 8, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
Owen D Gustafson, Matthew J Rowland, Peter J Watkinson, Stuart McKechnie, Simon Igo
OBJECTIVES: Identify the prevalence of shoulder impairment in ICU survivors within 6 months of discharge from ICU. Evaluate the impact of shoulder impairment on upper limb functional status in patients treated on an ICU. Identify risk factors for the development of shoulder impairment. DESIGN: Prospective cohort study. SETTING: A tertiary care medical-surgical-trauma ICU at a U.K. hospital over 18 months, with a further 6-month follow-up after hospital discharge...
August 7, 2018: Critical Care Medicine
Seema Radhakrishnan, Friedbert Kohler, Christoph Gutenbrunner, Arun Jayaraman, Karin Pieber, Jianin Li, Carolina Schiappacasse
BACKGROUND: International Classification of Function, Health and Disability provides a common framework and universal language for rehabilitation professionals across the globe. OBJECTIVES: To identify problems in functioning and mobility relevant to persons with lower-limb amputation from an expert's point of view and quantify these problems using the International Classification of Function, Health and Disability. STUDY DESIGN: Qualitative study using electronic and paper surveys...
August 10, 2018: Prosthetics and Orthotics International
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