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Critical burns

Dana A Schinasi, Irini N Kolaitis, Frances M Nadel, Yuemi An-Grogan, Rebekah Burns, Leah Berman, Annie M Quinn, Kathy N Shaw
Background Full disclosure of patient safety events (PSE) is desired by patients and their families, is required by the Joint Commission and many state laws, and is vital to improving patient outcomes. A key barrier to consistent disclosure of patient safety events is a self-reported lack of proper training. Physicians must be trained to recognize when a PSE has occurred and effectively carry out disclosure, all while caring for a patient who is actively experiencing the consequences of an unintended outcome...
August 3, 2018: Curēus
François Dépret, Louis Boutin, Jiří Jarkovský, Maité Chaussard, Sabri Soussi, Aurélien Bataille, Haikel Oueslati, Nabila Moreno, Christian de Tymowski, Jiří Parenica, Klára Benešová, Thomas Vauchel, Axelle Ferry, Mourad Benyamina, Alexandru Cupaciu, Maxime Coutrot, Jean-Pierre Garnier, Kevin Serror, Marc Chaouat, Alexandre Mebazza, Matthieu Legrand
OBJECTIVE: We aimed at assessing the predictive value of plasmatic Neutrophil Gelatinase Associated Lipocalin (pNGAL) at admission and severity scores to predict major adverse kidney events (MAKE, defined as death and/or need for renal replacement therapy (RRT) and/or non-renal recovery at day 90) in critically ill burn patients. MATERIAL AND METHODS: Single-center cohort study in a burn critical care unit in a tertiary center, including all consecutive severely burn patients (total burned body surface >20%) from January 2012 until January 2015 with a pNGAL dosage at admission...
October 12, 2018: Burns: Journal of the International Society for Burn Injuries
David N Dado, Benjamin Huang, Daniel V Foster, Jamison S Nielsen, Jennifer M Gurney, Benjamin D Morrow, Kumar Sharma, Kevin K Chung, Craig R Ainsworth
Calciphylaxis is a rare, necrotizing skin disorder usually associated with kidney disease, but also caused by many other systemic illnesses. This disease is associated with mortality rates as high as 80% at 1year. We present the demographic and clinical data of nine patients with calciphylaxis treated at our burn center over a 10year period. We review the literature on the clinical presentation, pathophysiology, diagnosis and treatment of this rare disease. We propose that these patients be treated similar to patients with thermal burn injury; meaning intensive wound care, surgical management, critical care and physical therapy...
October 12, 2018: Burns: Journal of the International Society for Burn Injuries
Maria G Grammatikopoulou, Xenophon Theodoridis, Konstantinos Gkiouras, Eleni-Maria Stamouli, Myrsini-Eleni Mavrantoni, Theodore Dardavessis, Dimitrios P Bogdanos
BACKGROUND: Severe burns are associated with a plethora of profound metabolic, immunologic, and physiologic responses, demanding prompt and adequate management. The objective of the present study was to review, compare, and critically appraise medical nutrition therapy guidelines for adult patients with severe burns, and produce salient points for the future update of relevant guidelines. METHODS: A total of 8 clinical practice guidelines developed by the American Burn Association (ABA), the European Burn Association (EBA), the European Society for Parenteral and Enteral Nutrition (ESPEN), the Midlands National Health Service, the Society for Critical Care Medicine (SCCM)/American Society for Parenteral and Enteral Nutrition (ASPEN), the Spanish Society of Intensive Care Medicine and Coronary Units and Spanish Society of Parenteral and Enteral Nutrition, the Indian Association for Parenteral and Enteral Nutrition (IAPEN), and the International Society for Burn Injury regarding medical nutrition therapy in burn patients was independently reviewed by a team of 4 multidisciplinary researchers using the Appraisal of Guidelines for Research & Evaluation (AGREE II) instrument...
October 15, 2018: JPEN. Journal of Parenteral and Enteral Nutrition
Bo Chen
OBJECTIVES: Schizophrenia is a predominant product of pathological alterations distributed throughout interconnected neural systems. Designing new objectively diagnostic methods are burning questions. Dynamical functional connectivity (DFCs) methodology based on fMRI data is an effective lever to investigate changeability evolution in macroscopic neural activity patterns underlying critical aspects of cognition and behavior. However, region properties of brain architecture have been less investigated by special indexes of dynamical graph in general mental disorders...
October 11, 2018: Journal of Neuroscience Methods
Ellen M Denzen, Jaime M Preussler, Elizabeth A Murphy, K Scott Baker, Linda J Burns, Jackie Foster, Lensa Idossa, Heather K Moore, Tammy J Payton, Darlene Haven, Balkrishna Jahagirdar, Naynesh Kamani, J Douglas Rizzo, Lizette Salazar, Barry A Schatz, Karen L Syrjala, John R Wingard, Navneet S Majhail
PURPOSE: This study aimed to develop a survivorship care plan (SCP) that could be individualized to facilitate long-term follow-up care of hematopoietic cell transplantation (HCT) survivors. METHODS: A sample SCP was developed that included two documents- a treatment summary and preventive care recommendations that combined data on treatment exposures routinely submitted by HCT centers to the Center for International Blood and Marrow Transplant Research (CIBMTR) with long-term follow-up guidelines...
October 10, 2018: Biology of Blood and Marrow Transplantation
Nermeen M Galal, Safaa Meshaal, Rabab ElHawary, Eman Nasr, Laila Bassiouni, Humayun Ashghar, Noha H Farag, Ondrej Mach, Cara Burns, Jane Iber, Qi Chen, Aisha ElMarsafy
OBJECTIVE: Primary immunodeficiency (PID) patients are prone to developing viral infections and should not be vaccinated with live vaccines. In such patients, prolonged excretion and viral divergence may occur and they may subsequently act as reservoirs in the community introducing mutated virus and jeopardizing polio eradication. One hundred and thirty PID cases were included for poliovirus detection in stool with assessment of divergence of detected polioviruses from oral polio vaccine (OPV) virus...
October 11, 2018: BMC Research Notes
Margaret A Fitzpatrick, Katie J Suda, Makoto M Jones, Stephen P Burns, Linda Poggensee, Swetha Ramanathan, Martin Evans, Charlesnika T Evans
BACKGROUND: Patients with spinal cord injury (SCI) have a high risk for multidrug-resistant organisms, including carbapenem-resistant Enterobacteriaceae (CRE). Accurate and easily applied definitions are critical to identify CRE. This study describes CRE and associated characteristics in veterans with SCI per Centers for Disease Control and Prevention (CDC) and Department of Veterans Affairs (VA) definitions. METHODS: A retrospective cohort of veterans with SCI and more than 1 culture with Escherichia coli, Klebsiella spp and/or Enterobacter spp between 2012 and 2013 was examined...
October 6, 2018: American Journal of Infection Control
Manu Shankar Hari, Charlotte Summers
PURPOSE OF REVIEW: The purpose of this review is to provide an overview of the immune response to major surgery, and the ways in which it may be modulated to improve postoperative outcomes. RECENT FINDINGS: Data from patients who have undergone a variety of tissue injuries (surgery, burns, sepsis, trauma) have shown the presence of a conserved 'genomic storm' that alters the leukocyte transcriptome, with upregulation of the innate immune response and concomitant downregulation of the adaptive immune response...
October 6, 2018: Current Opinion in Critical Care
Maryam Rabiei, Ehsan Kazemnezhad Leili, Leili Alizadeh
Background and Aim: Burning mouth syndrome (BMS) may be defined as a burning sensation in the oral mucosa usually unaccompanied by clinical signs. Multiple conditions have been attributed to a burning sensation. The aim of this study was to determine the role of age and sex in BMS. Materials and Methods: A total of 195 consecutive patients with BMS and 95 healthy patients without burning sensation were recruited in this study. Patients with BMS had experienced oral, burning sensations for at least 6 months without oral clinical signs, and with a normal blood count...
September 2018: Contemporary Clinical Dentistry
S D Ge
As an initial member of burn medicine in China, I am lucky to participate in the activity of writing paper for the journal to celebrate the 60th anniversary of the founding of burn medicine in China. It is a chance to introduce my clinical work, laboratory study, and teaching. I review the development of burn surgery to make some points in the transformation and development of burn surgery, some suggestions for better coordination between burn surgery and critical care medicine during emergency support for mass burn casualties...
September 20, 2018: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
Tara A Burns, Raymond N Deepe, John Bullard, Aimee L Phelps, Katelynn A Toomer, Emilye Hiriart, Russell A Norris, Courtney J Haycraft, Andy Wessels
Primary cilia are small organelles projecting from the cell surface of many cell types. They play a crucial role in the regulation of various signaling pathway. In this study, we investigated the importance of cilia for heart development by conditionally deleting intraflagellar transport protein Ift88 using the col3.6-cre mouse. Analysis of col3.6;Ift88 offspring showed a wide spectrum of cardiovascular defects including double outlet right ventricle and atrioventricular septal defects. In addition, we found that in the majority of specimens the pulmonary veins did not properly connect to the developing left atrium...
October 5, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Patrick Amoatey, Hamid Omidvarborna, Mahad Said Baawain, Abdullah Al-Mamun
Indoor air pollution is one of the human health threat problems in the Gulf Cooperation Council (GCC) countries. In these countries, due to unfavorable meteorological conditions, such as elevated ambient temperature, high relative humidity, and natural events such as dust storms, people spend a substantial amount of their time in indoor environments. In addition, production of physical and biological aerosols from air conditioners, cooking activities, burning of Arabian incense, and overcrowding due to pilgrimage programs are common causes of low quality indoor air in this region...
October 1, 2018: Environment International
Qiongyuan Hu, Quan Zhou, Jie Wu, Xiuwen Wu, Jianan Ren
Ischemia/reperfusion (I/R) injury is a common occurrence resulting from acute mesenteric ischemia, traumatic or septic shock, burns, and surgical procedures that can lead to multiple organ failure and high mortality in critically ill patients. Mitochondria are often considered as the cellular power factory via their capacity for ATP generation. Recently, mitochondria have been further identified as vital regulators of cell death, inflammation, and oxidative stress, all of which can aggravate I/R injury. Studies have indicated that mitochondrial DNA (mtDNA) damage leads to mitochondrial dysfunction and aggravates I/R injury...
October 3, 2018: Shock
Reza Akbari, Mojdeh Hakemi-Vala, Fatemeh Pashaie, Parvaneh Bevalian, Ali Hashemi, Kamran Pooshang Bagheri
BACKGROUND: Morbidity and mortality due to multidrug-resistant (MDR) bacteria are of great concern in burn patients. In this critical condition, synergism between antimicrobial peptides and conventional antibiotics would be a promising strategy. Accordingly, this study aimed to determine the therapeutic value of melittin as a natural peptide by examining its synergistic effect with conventional antibiotics against MDR isolates of Acinetobacter baumannii and Pseudomonas aeruginosa. MATERIALS AND METHODS: Fifteen clinical isolates for each kind of bacteria were collected from burn patients...
October 3, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
Jian Sun, Wei Huang, Shuo-Fei Yang, Xiao-Pei Zhang, Qing Yu, Zhi-Qing Zhang, Jin Yao, Ke-Ran Li, Qin Jiang, Cong Cao
VEGF binding to VEGFR2 leads to VEGFR2 endocytosis and downstream signaling activation to promote angiogenesis. Methods: Using genetic strategies, we tested the requirement of α subunits of heterotrimeric G proteins (Gαi1/3) in the process. Results: Gαi1/3 are located in the VEGFR2 endocytosis complex (VEGFR2-Ephrin-B2-Dab2-PAR-3), where they are required for VEGFR2 endocytosis and downstream signaling transduction. Gαi1/3 knockdown, knockout or dominant negative mutation inhibited VEGF-induced VEGFR2 endocytosis, and downstream Akt-mTOR and Erk-MAPK activation...
2018: Theranostics
Megan Y Roberts, Philip Curtis, Ryne Estabrook, Elizabeth S Norton, Matthew M Davis, James Burns, Margaret Briggs-Gowan, Amelie Petitclerc, Lauren S Wakschlag
OBJECTIVE: The goal of this article is to investigate the association between the 2 most commonly reported parental concerns about young children-disruptive behavior (e.g., irritable, aggressive, and noncompliant behaviors) and language delay in toddlers. To test for salient subgroup differences, individual differences by the sex of the child and family poverty status were examined. METHODS: Participants included 1259 mothers of children between 18 and 36 months of age...
October 1, 2018: Journal of Developmental and Behavioral Pediatrics: JDBP
Oressia Zalucki, Lachlan Harris, Tracey J Harvey, Danyon Harkins, Jocelyn Widagdo, Sabrina Oishi, Elise Matuzelski, Xuan Ling Hilary Yong, Hannes Schmidt, Victor Anggono, Thomas H J Burne, Richard M Gronostajski, Michael Piper
Understanding the migration of newborn neurons within the brain presents a major challenge in contemporary biology. Neuronal migration is widespread within the developing brain but is also important within the adult brain. For instance, stem cells within the ventricular-subventricular zone (V-SVZ) and the subgranular zone of dentate gyrus of the adult rodent brain produce neuroblasts that migrate to the olfactory bulb and granule cell layer of the dentate gyrus, respectively, where they regulate key brain functions including innate olfactory responses, learning, and memory...
October 1, 2018: Cerebral Cortex
Berangere A Leys, Jennifer R Marlon, Charles Umbanhowar, Boris Vannière
Grasslands are globally extensive; they exist in many different climates, at high and low elevations, on nutrient-rich and nutrient-poor soils. Grassland distributions today are closely linked to human activities, herbivores, and fire, but many have been converted to urban areas, forests, or agriculture fields. Roughly 80% of fires globally occur in grasslands each year, making fire a critical process in grassland dynamics. Yet, little is known about the long-term history of fire in grasslands. Here, we analyze sedimentary archives to reconstruct grassland fire histories during the Holocene...
September 2018: Ecology and Evolution
Federica D'Asta, Joseph Homsi, Idanna Sforzi, David Wilson, Marco de Luca
Acute management of a severely burned patient is an infrequent and stressful situation that requires medical knowledge as well as immediate coordinated action. Many adverse events in health care result from issues related to the application of 'non-technical' skills such as communication, teamwork, leadership and decision making rather than lack of medical knowledge. Training in these skills is known as Crisis Resource Management (CRM) training. In order to create well-prepared burn teams, it is critical to teach CRM principles through high-fidelity simulation (HFS)...
September 26, 2018: Burns: Journal of the International Society for Burn Injuries
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